How to use phosphatide in a sentence? Find typical usage patterns (collocations)/phrases/context for "phosphatide" and check conjugation/comparative form for "phosphatide". Mastering all the usages of "phosphatide" from sentence examples published by news publications.
He would sometimes insert punctuation for the benefit of his secretary, or spell out complicated medical terms. Phosphatide. Lipoxygenase.
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Sphingosyl phosphatide refers to a lipid containing phosphorus and a long- chain base.
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Heparin was discovered by Jay McLean and William Henry Howell in 1916, although it did not enter clinical trials until 1935. It was originally isolated from dog liver cells, hence its name (hepar or "ήπαρ" is Greek for "liver"; hepar + -in). McLean was a second-year medical student at Johns Hopkins University, and was working under the guidance of Howell investigating pro-coagulant preparations, when he isolated a fat-soluble phosphatide anticoagulant in canine liver tissue. In 1918, Howell coined the term 'heparin' for this type of fat-soluble anticoagulant.
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In the early 1920s, Howell isolated a water-soluble polysaccharide anticoagulant, which he also termed 'heparin', although it was different from the previously discovered phosphatide preparations. McLean's work as a surgeon probably changed the focus of the Howell group to look for anticoagulants, which eventually led to the polysaccharide discovery. In the 1930s, several researchers were investigating heparin. Erik Jorpes at Karolinska Institutet published his research on the structure of heparin in 1935, which made it possible for the Swedish company Vitrum AB to launch the first heparin product for intravenous use in 1936.
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McLean entered Johns Hopkins School of Medicine in 1915 where he met and began work with physiologist William Henry Howell. In 1916, when McLean was a second-year medical student, he was investigating pro-coagulant compounds when he first isolated a fat-soluble phosphatide anti-coagulant. This anti-coagulant was first isolated from the liver tissue of canines, which is how Heparin got its name(hepar or "ήπαρ" is Greek for "liver"; hepar + -in), first coined in 1918. Following the departure of McLean, Howell continued his work and with the assistance of T. Emmett Holt he isolated a water-soluble polysaccharide anticoagulant.
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Note ether at first position, and acetyl group at second position. In an organic chemistry general sense, an ether lipid implies an ether bridge between an alkyl group (a lipid) and an unspecified alkyl or aryl group, not necessarily glycerol. If glycerol is involved, the compound is called a glyceryl ether, which may take the form of an alkylglycerol, an alkyl acyl glycerol, or in combination with a phosphatide group, a phospholipid. In a biochemical sense, an ether lipid usually implies glycerophospholipids of various type, also called phospholipids, in which the sn-1 position of the glycerol backbone has a lipid attached by an ether bond and a lipid attached to the sn-2 position via an acyl group.
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