89 Sentences With "desensitizing" | Random Sentence Generator

Do it long enough and the routine will become desensitizing.

Using desensitizing CDs at home was only about 50 percent effective.

It was a triple-thick desensitizing lubricated condom for guys with stamina problems.

We were like the first RuPaul's Drag Race, desensitizing people to alternative lifestyles.

The droop is caused by alcohol's penchant for desensitizing and slowing reaction time.

Miocic immediately got to work desensitizing Hunt's counter instincts with feints and jabs.

Mr. Lieberman led the charge in denouncing such games as desensitizing young players.

Media violence affects different kids in different ways, and overexposure can be desensitizing.

Mental health experts warn these live streams risk desensitizing the public and encouraging copycats.

The Ranger Indoctrination Program is undoubtedly brutal, desensitizing infantrymen to the realities of violence.

Vox Lux is concerned with the desensitizing powers of idol worship, with all its relevant connections.

"You run the risk of desensitizing people of the issue," said Mark Orlando, CTO of Raytheon's cybersecurity practice.

In desensitizing your own audience to just how bad these actions are, because they are starting to feel absurd.

As Mr. Gibson notes, euphemisms have been invading the headlines, desensitizing the public to the tragedy of gun violence.

But it feels like repeatedly poking fun at and desensitizing actual tragedies and abusive behavior is a line we're crossing needlessly.

Reproducing and repurposing brutal visuals carries the risk of desensitizing, and further reinforcing the terrorizing normalization of what shouldn't be mundane.

Then he told us what he had learned from training soldiers, from desensitizing them to their natural aversion to killing up close.

I've written before about how lynching photos extend into present day's shareable media incarnations of anti-Black violence, which are disseminated and desensitizing.

But too much of that would probably be desensitizing to sex in real life," he speculates, "because that's not how real sex works.

Also, many pets are scared by loud noises — The New York Times Well Blog lists numerous remedies and suggestions for desensitizing your pet. 5.

Desensitizing the public The President's proclamation that he can pardon himself is raising the ante on the media circus surrounding his pardons for others.

The optimal solution, vets say, is catching the response early, and desensitizing the dog with calibrated recordings of the offending noise, and positive conditioning.

If we do, we might even run the risk of desensitizing people, who will end up taking this issue less seriously than they should.

So the key to desensitizing the aryl hydrocarbon receptor was probably already present inside killifish DNA, and natural selection simply brought it to the fore.

Natalie Portman stars as a pop star who survived a school shooting in director Brady Corbet's new film about the desensitizing powers of idol worship.

Donald Trump believes video games are partly to blame for the mass shootings in America -- claiming the "glorification of violence" is desensitizing potential real-life killers.

We caught up with Brüggemann to talk about the Western adage that "ignorance is bliss" and how traditional forms of photojournalism are desensitizing us and ruining everything.

Therapists use it to treat P.T.S.D. and phobias by exposing patients to their worst fears in controlled doses, eventually desensitizing them to whatever is causing their anxiety.

We're berated with desensitizing information all the time, but try your best to be kind and come from a place of unconditional love, because that's all that matters.

But by experiment's end, the toothpastes branded as either anti-erosive or desensitizing failed to prevent erosion significantly better than the plain one (Colgate Cavity Protection) the researchers used.

McCarthy's work can be understood not only as a direct response to the desensitizing effects of technology, but also to the dehumanizing attitudes of big tech companies at large.

They mulled over the importance of grief, of not shying away from or desensitizing the pain, of what the Parkland shooting survivors did, and why the community needs this production.

The clumsy foreshadowing notwithstanding, the scene's anticlimactic nature exposes a fundamental paradox of the show: The stakes of the series' very first scene were possibly too high, and thus desensitizing.

By exclusively focusing on nameless extras being burned alive over and over again, "The Bells" dehumanized the citizens of King's Landing, desensitizing and numbing viewers to their tragic loss of life.

In a video, Gilbert explained that what made his "delay spray" new and different was a formula that allowed lidocaine to be absorbed under a man's skin without desensitizing his partner.

I don't think violent imagery is the sole cause of people being violent, but I'd be lying if I said I didn't think it had at least some influence in desensitizing us.

If Trump's racism, sexism, general bigotry, loose talk about democratic norms, and so on were really desensitizing Americans and permanently altering US norms, why do so many Americans appear to despise the man?

Those who have developed and fine-tuned the system know that figure rarely bears much relation to the price they will be quoted once soccer's transfer window — that dizzying, desensitizing biannual bazaar — opens for business.

Experts told BuzzFeed News the recent uptick is likely due to the amount of attention the attacks get and the fixation on the people behind them, spurring copycats while at the same time desensitizing the public.

But beating that damaged deep tissue into submission has a desensitizing effect, and if you've ever tried a cheap As Seen On TV massager on back knots, you know it takes some oomph to feel anything.

If you find that they don't work for you, or you just aren't comfortable with the idea of desensitizing your penis in the first place, other self-help options include Kegel exercises and the stop-start technique.

So in the case of Trump, the sheer number of sexual misconduct allegations seems to have had a desensitizing effect, with the press and the public beginning to treat an account of sexual assault by the US commander-in-chief as simply business as usual.

On the one hand, is there a risk of desensitizing, especially younger people perhaps; on the other hand, if they're not actually interacting in real life, then maybe these sorts of performances or acts aren't happening in real life, which is the other side of it.

In his June 1 op-ed ("Kathy Griffin's distasteful act reflects media's war on Trump") for The Hill, Bill O'Reilly chastised the "left wing national media" for desensitizing Americans to the point that they can't tell right from wrong, using the recent Kathy Griffin photo controversy as its basis.

For this reason, while further studies would certainly be welcomed, very few clinical psychologists consider it to be a valid therapy, and are more likely to suggest a proven approach, such as Eye Motion Desensitizing and Reprocessing (EMDR) for patients suffering distress in association with particular memories, circumstances, or experiences.

The idea of oral immunotherapy dates back to 1908, when a British doctor first reported desensitizing a child with an egg allergy to eggs by giving him small amounts of egg to eat over time, said Dr. Brian P. Vickery, the lead author of the paper, who was the lead scientist for the study and an employee of Aimmune Therapeutics while the trial was being carried out.

Avoidance of the trigger of anaphylaxis is recommended. In cases where this may not be possible, desensitization may be an option. Immunotherapy with Hymenoptera venoms is effective at desensitizing 80–90% of adults and 98% of children against allergies to bees, wasps, hornets, yellowjackets, and fire ants. Oral immunotherapy may be effective at desensitizing some people to certain food including milk, eggs, nuts and peanuts; however, adverse effects are common.

At this temperature, nitroglycerin freezes, contracting upon solidification. Thawing it out can be extremely sensitizing, especially if impurities are present or the warming is too rapid. Chemically "desensitizing" nitroglycerin is possible to a point where it can be considered about as "safe" as modern high explosives, such as by the addition of roughly 10 to 30% ethanol, acetone, or dinitrotoluene (the percentage varies with the desensitizing agent used). Desensitization requires extra effort to reconstitute the "pure" product.

The rapidly activating, desensitizing, inward current is predominantly carried by sodium and potassium ions. 5-HT3 receptors have a negligible permeability to anions. They are most closely related by homology to the nicotinic acetylcholine receptor.

Beta arrestin is important for ceasing the response of a receptor to a stimuli. Beta arrestin also brings with it other proteins that internalize the receptor which also helps in desensitizing the cell to the stimuli.

Prenoxdiazine (marketed as Libexin) is a cough suppressant. It acts peripherally by desensitizing the pulmonary stretch receptors. Therefore, there's a reduction of cough impulses originating in the lungs. Prenoxdiazine is indicated in cough of bronchial origin.

In 2020 Zoe Rosenberg launched a Youth Activism Campaign against the animal agriculture practices of 4-H and FFA on behalf of animals, arguing that by teaching kids to raise animals for slaughter, these organizations are desensitizing youth to the pain and suffering of non-human sentient creatures.

These products, DenClude and ProClude were sold to Colgate Palmolive in 2008. ProClude, is now called Colgate Sensitive Pro Relief Desensitizing Paste with Pro Argin Technology.Colgate Sensitive Pro- Relief, "Colgate Professional", 2013 The company is also in late stage development of an electronic early cavity detector, called the Ortek ECD.

The enzyme beta glucuronidase appears to potentiate the desensitizing effect of a small dose of allergen. The quantities of both are smaller than those occurring naturally in the body, but not so small that they can be regarded as homeopathic. Intradermal injections are used. The treatment takes 3–4 weeks before any effect is seen.

Lax, haunted by his own past, is now face to face with Herman. Herman is executed in the electric chair. The movie explores why and how a massacre like this can happen in our society, desensitizing in America, youth violence and bullying, the impact the media has on our individual quest for fame, and ultimately our need for connection.

Dessirier et al., 2001, also claim the cross-desensitization of menthol receptors can occur by unknown molecular mechanisms, though they hypothesize the importance of Ca2+ in reducing cell excitability in a way similar to that in the capsaicin receptor. Mutagenesis of protein kinase C phosphorylation sites in TRPM8 (wild type serines and threonines replaced by alanine in mutants) reduces the desensitizing response.

This is unlike orthosteric drugs, which tend to produce a less targeted effect within body on all of the receptors they can bind to. Some modulators have also been shown to lack the desensitizing effect that some agonists have. Nicotinic acetylcholine receptors, for example, quickly desensitize in the presence of agonist drugs, but maintain normal function in the presence of PAMs.

This differs from acetylcholine, which is rapidly degraded and only transiently depolarizes the muscle. There are two phases to the depolarizing block. During phase I (depolarizing phase), they cause muscular fasciculations (muscle twitches) while they are depolarizing the muscle fibers. Eventually, after sufficient depolarization has occurred, phase II (desensitizing phase) sets in and the muscle is no longer responsive to acetylcholine released by the motoneurons.

Tar is the common name for the resinous, partially combusted particulate matter made by the burning of tobacco and other plant material in the act of smoking. Tar is toxic and damages the smoker's lungs over time through various biochemical and mechanical processes. Tar also damages the mouth by rotting and blackening teeth, damaging gums, and desensitizing taste buds. Tar includes the majority of mutagenic and carcinogenic agents in tobacco smoke.

Cosmetic or functional intervention may be required if tooth surface loss is pathological or if there has been advanced loss of tooth structure. The first stage of treatment involves managing any associated conditions, such as fractured teeth or sharp cusps or incisal edges. These can be resolved by restoring and polishing sharp cusps. Then, desensitizing agents such as topical fluoride varnishes can be applied, and at home desensitising toothpastes recommended.

This type of block occurs when the desensitizing phase sets in and the muscle is no longer responsive to acetylcholine and full neuromuscular blockade is achieved. TOF fade is indicative of phase II block that is likely to occur in patients who received succinylcholine and may resemble features of a nondepolarizing block. During phase II, reversal with neostigmine should not be attempted. Anticholinesterase agents can worsen paralysis in this setting.

Pharmacodynamic tolerance begins when the cellular response to a substance is reduced with repeated use. A common cause of pharmacodynamic tolerance is high concentrations of a substance constantly binding with the receptor, desensitizing it through constant interaction. Other possibilities include a reduction in receptor density (usually associated with receptor agonists), or other mechanisms leading to changes in action potential firing rate. Pharmacodynamic tolerance to a receptor antagonist involves the reverse, i.e.

Many topical treatments for dentin hypersensitivity are available, including desensitizing toothpastes and protective varnishes that coat the exposed dentin surface. Treatment of the root cause is critical, as topical measures are typically short lasting. Over time, the pulp usually adapts by producing new layers of dentin inside the pulp chamber called tertiary dentin, increasing the thickness between the pulp and the exposed dentin surface and lessening the hypersensitivity.

Govt efforts key to desensitizing religious management, Global Times The church had been registered with the government authorities. The demolition was preceded by a petition by local believers of the Chinese folk faith accusing the church to disrupt the area's feng shui (cosmic harmony), highlighting the tensions between indigenous religious groups and Christianity.Razing of church stuns Christians in China. On International New York Times, Friday, May 30, 2014.

In 2015, flibanserin was approved in the US to treat decreased sexual desire in women. While it's effective for some women, it has been criticized for its limited efficacy, and many warnings and contraindications that limit its use. name=WebMD Women experiencing pain with intercourse are often prescribed pain relievers or desensitizing agents; others can be prescribed vaginal lubricants. Many women with sexual dysfunction are also referred to a counselor or sex therapist.

It is more potent than capsaicin and is currently in development as a sensory neuron desensitizing agent. Initially, agonists were the major focus of the TRPV1 ligand development due to the analgesic effect resulting from desensitization of the receptor. However, because of an initial burning effect of all natural vanilloid receptor agonists, including capsaicin, therapy becomes complicated and perhaps ineffective. Attempts to make synthetic agonists with good separation between excitatory effects and the analgesic effects have not been successful.

Another treatment option is the topical solution of cocaine HCl which also provides relief for a short time period by acting as an anesthetic and desensitizing the nasal neurons. The topical solution is applied on the nostril. This topical solution can have several side effects as it has been found that some patients suffering from troposmia started to show symptoms of phantosmia after its use. Other patients have lost complete function of the nostril where the drug was applied.

Of these, Q50R and G159D co- segregated with disease in affected family members, increasing confidence that they are clinically significant mutations. The biochemical consequences of thin filament DCM-associated mutations are less well established than for HCM, although there has been some suggestion that some of the mutations abolish the calcium desensitizing effect of cTnI phosphorylation at Ser22/23. This may be because some mutations disrupt the precise positioning of cNTnC for triggering muscle contraction when cTnI is unphosphorylated.

The institute provides 80,000 dialyses each year. In addition to traditional hemodialysis, The Rogosin Institute offers patients a number of options, including peritoneal dialysis and home nocturnal hemodialysis. Dialysis centers are located in Manhattan, Brooklyn, and Queens. The Rogosin Institute is a pioneer in the implementation of technologies that make kidney transplantation more accessible and successful, such as programs for highly sensitized transplant recipients, the use of steroid-free protocols, desensitizing programs for incompatible donors, and donor exchange programs.

Sorrento Therapeutics has been developing RTX as a means to provide pain relief for forms of advanced cancer. The nerve desensitizing properties of RTX were once thought to be useful to treat overactive bladder (OAB) by preventing the bladder from transmitting “sensations of urgency” to the brain, similar to how they can prevent nerves from transmitting signals of pain; RTX has never received FDA approval for this use. RTX has also previously been investigated as a treatment for interstitial cystitis, rhinitis, and lifelong premature ejaculation (PE).

There are many applications of inhibitory postsynaptic potentials to the real world. Drugs that affect the actions of the neurotransmitter can treat neurological and psychological disorders through different combinations of types of receptors, G-proteins, and ion channels in postsynaptic neurons. For example, studies researching opioid receptor-mediated receptor desensitizing and trafficking in the locus cereleus of the brain are being performed. When a high concentration of agonist is applied for an extended amount of time (fifteen minutes or more), hyperpolarization peaks and then decreases.

On October 20, 2010, Chesser pleaded guilty to three felonies: communicating threats to Parker and Stone, soliciting violent jihadists to "desensitize" law enforcement, and attempting to provide material support to a designated foreign terrorist organization. "Desensitizing" law enforcement referred to plans to place suspicious-looking but inoffensive packages in public places, until police became lax about dealing with them, at which point a real explosive could be used. These three charges carried a maximum of 30 years in prison; Chesser's sentence was 25 years.

Her work on sociable media has applications in the field of semiotics. On the subject of telerobotics, Donath argues that the remote manipulation afforded by the discipline may act as a desensitizing agent because the identity and human characteristics of the remote subjects of the telerobotic operation remain unseen by the human teleoperator of the robot. She has also researched the ethnography of online communities. Her work includes the application of architectural principles to the design of the social interaction environment of online communities in a kind of virtual city.

The molecular mechanism of smooth muscle relaxation involves the enzyme CGMP-dependent protein kinase, also known as PKG. This kinase is activated by cGMP and it phosphorylates multiple targets in the smooth muscle cells, namely myosin light chain phosphatase, RhoA, IP3 receptor, phospholipase C, and others. Overall, this results in a decrease in intracellular calcium and desensitizing proteins to the effects of calcium, engendering smooth muscle relaxation. Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

For example, the LTC6702, MAX9021 and MAX9031 have internal hysteresis desensitizing them from input noise. In place of one switching point, hysteresis introduces two: one for rising voltages, and one for falling voltages. The difference between the higher-level trip value (VTRIP+) and the lower-level trip value (VTRIP-) equals the hysteresis voltage (VHYST). If the comparator does not have internal hysteresis or if the input noise is greater than the internal hysteresis then an external hysteresis network can be built using positive feedback from the output to the non-inverting input of the comparator.

The expression condenses three principles:the first supposition is that informational excess could lead to a tragic numbness and social detachment. It has to do with the social risks associated with technology use, namely, the threat of desensitizing the individual’s awareness by means of a surplus of means of communication. The second assumption relies on the assertion that to know is the same as to act. The narcotizing dysfunction draws attention to the fact that individuals tend to consider that because they are informed about a subject, they are necessarily concerned with it—as if there was a correspondence between information and political commitment.

Some theorists charge that the acceptance of these sexual practices increase sexual violence against women, by reinforcing stereotypical views about women, who are seen as sex objects which can be used and abused by men, and by desensitizing men; this being one of the reasons why some theorists oppose the sex industry. They argue that pornography eroticizes the domination, humiliation, and coercion of women, and reinforces sexual and cultural attitudes that are complicit in rape and sexual harassment. The anti- pornography feminist, Andrea Dworkin, has famously argued this point in her controversial Pornography: Men Possessing Women (1981).

Desensitizing an otherwise trained horse to accept the fluttering skirt of a lady's riding habit. :The phrase "sack out" also refers to going to sleep. Sacking out is a method used by horse trainers to desensitize a horse to potentially frightening situations or objects. It is a process that, done properly, teaches a horse to not fear certain objects or situations, and, over time can be used to teach a horse to stop and listen to its handler in any potentially frightening situation, thus, in effect, to assess the situation instead of immediately acting upon its fight or flight instinct.

Harris and Barlett concluded that a few studies have developed extensive pre-exposure training and/or post-exposure debriefing procedures to lessen the desensitizing effects. Linz found that by offering pertinent educational information about rape myths reduced the effect of desensitization, which means experimental participation can also help reduce the rape myth acceptance. Wilson, Linz, Donnerstein, and Stipp conducted a field experiment, they found that men who are older than 50 had preexisting attitudes reinforced and actually blamed women for rape after seeing the film. In other words, preexisting attitudes and personal experience should be considered when conducting research studies.

Its formula of 5% glutaraldehyde and 35% HEMA (hydroxyethyl methacrylate) in waterHeraeus-Kulzer: GLUMA is used to help control both hypersensitive dentin and reduce the incidence of post-operative sensitivity in restorative dentistry procedures. It’s also useful as a cavity disinfectant, a rewetting agent and an adhesion promoter (when combined with most dentin bonding systems). Research indicates that when used as a desensitizer under bonded restorative material, Gluma has no significant influence on bond strength, unlike some other liners, which contribute to a decrease in bond strength.Kobler, A; Schaller, HG; Gernhardt, CR: Effects of the desensitizing agents Gluma and Hyposen on the tensile bond strength of dentin adhesives.

" She described Ranaut's work as "Kangana's lack of vanity onscreen is among her many strengths. She isn't afraid to look unattractive or behave badly." From Rediff.com, Vaihayasi Pande Daniel gave Simran 3 out of 5 stars "Simran is a light-hearted, time-pass film not attempting to explore any higher themes." Pointing to some contrivances Kunal Gupta of Mumbai Mirror gave 2.5 out of 5 stars slating the film's casual tone as distracting and desensitizing during the crime scenes. Umesh Punwani from Koimoi declared "Simran is all about Kangana Ranaut, 5 minutes into the film and you know this is going to be special.

An example of the need for desensitizing training is when an object, such as a plastic bag, suddenly blows across the path of horse and rider, which, if the horse has not been properly desensitized, could result in spooking. Spooking is potentially dangerous, as it can result in fallen riders or horses bolting into danger. Another example would be the need to desensitize a horse to the sound of traffic, music, loudspeakers and other stimuli seen at public events. In some cases, a previous bad experience may have given a horse reason to fear a specific situation, requiring a form of systematic desensitization to gradually overcome its fear.

While experimenting on subatomic particles, a team of physics researchers start a chain reaction that seemingly controls the researchers themselves. As one scientist after another is consumed and turned into nuclear 'zombies' by what seems to be a form of sentient particles from another dimension, the reaction grows towards a terrible climax, and the survivors fear they may be powerless to stop it. Just as the ever-expanding particles are about to engulf the lab and explode into an atomic cataclysm that could destroy the world, the head of the research facility calculates a formula to reverse the effects of the reaction, incorporates a random element, and succeeds in desensitizing the new lifeform, rendering it powerless.

Another problem with wearing a splint can be stimulation of salivary flow, and for this reason some advise to start wearing the splint about 30 mins before going to bed so this does not lead to difficulty falling asleep. As an added measure for hypersensitive teeth in bruxism, desensitizing toothpastes (e.g. containing strontium chloride) can be applied initially inside the splint so the material is in contact with the teeth all night. This can be continued until there is only a normal level of sensitivity from the teeth, although it should be remembered that sensitivity to thermal stimuli is also a symptom of pulpitis, and may indicate the presence of tooth decay rather than merely hypersensitive teeth.

He is best known for his work on heterologous down-regulation of EGF receptor by NGF, which would appear to be an efficient mean of desensitizing the neurons to proliferative signals. Lazarovici pursued neuroscience as a visiting associate in the Section on Growth Factors at National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA. After completion of his research, he joined as Lecturer in The School of Pharmacy, The Hebrew University of Jerusalem and later he became the full Professor. He is an active member of the Israel Societies for Physiology and Pharmacology (ISPP), and Neuroscience (ISN), American Societies for Neuroscience (ASN), and Pharmacology and Experimental Therapeutics (ASPET). Lazarovici was part of the Israeli group developing with TEVA Co. the drug for Parkinson’s named Rasagiline (Azilect).

Fel d1 is a protein primarily found in cat saliva and sebaceous glands. Those with cat allergies may react worse to direct contact with Sphynx cats than other breeds; even though reports exist that some people with allergies successfully tolerate Sphynx cats, they are fewer than those who have allergic reactions, according to David Rosenstreich, MD, the director of the Division of Allergy and Immunology at the Albert Einstein College of Medicine and Montefiore Medical Center in the Bronx, New York City, New York. These positive reports may be cases of desensitizing, wherein the "hairless" cat gave the owner optimism to try to own a cat, eventually leading to the positive situation of their own adaptation. Sphynx cats can also have more ear wax than most hairy domestic cats because they have little to no hair in their ears.

His work, when sold in galleries, can fetch six-figure sums. Hong Kong Phooey (HK 58), sold for US$250,000 in early 2015 Fellow street artist Shepard Fairey wrote in Swindle: > Invader's pop art may seem shallow, but by taking the risk of illegally re- > contextualizing video game characters in an urban environment that provides > more chaotic social interaction than a gamer's bedroom, he makes a statement > about the desensitizing nature of video games and consumer culture. In a > postmodern paradox, a game like Grand Theft Auto takes the danger of the > streets and puts it in a safe video game, while Invader takes a safe video > game icon and inserts it into the danger of the streets. During an early 2014 "invasion" in Hong Kong comprising a total of 48 works, the city's Highways Department removed the life-sized Hong Kong Phooey (HK 58) mosaic, which had been placed by the side of a road in Fortress Hill.

Slap the Monster on Page One (Italian: Sbatti il mostro in prima pagina) is a 1972 Italian drama film directed by Marco Bellocchio. It depicts the daily life of a fictitious Italian daily newspaper Il Giornale (The Journal). The newspaper caters to a conservative, fascist, borgeouis public and its chief- editor Bizanti tries in all manners to give a right-wing slant even to the most trivial news items, while at the same time edulcorating and desensitizing the thornier issues, such as unemployment, police brutality and so on. The whole editorial staff is thrown in a tantrum when a young girl is found raped and killed, going as far as soliciting death penalty nostalgias (capital punishment has been abolished in Italy since the fall of Fascism) and to actually derail the investigation leading the police to a false culprit: a young left-wing student which becomes the "ideal" scapegoat for the newspaper's prejudiced readership.

Benita "Benny" Diaz Lopez (Belita Moreno) is George and Linda's mother, Angie's mother-in-law, and Carmen and Max's paternal grandmother; a wise-cracking, outspoken, insensitive alcoholic who was responsible for George's frequently-mentioned traumatic childhood. Conceiving him in the back of a car wash after engaging in premarital sexual relations with Manny Lopez, Benny wed her lover shortly afterward, only for Manny to divorce her during George's infanthood. After convincing George that his father had died, Benny showed her son an abusive, dysfunctional home life and childhood, desensitizing him to her constant criminal actions as if they were any normal occurrences, guarding numerous other secrets from her son as well that were unveiled during his adulthood. Many episode plots had often been established through George's discovery of a protected secret, such as the revelation of his having a sister named Linda (who had enjoyed a far more loving childhood after Benny had given her up for adoption), and many jokes had been brought up referencing one of Benny's numerous acts of child abuse directed toward George and mistreatment of him.

Do it long enough and the routine will become desensitizing. from The New York Times
Using desensitizing CDs at home was only about 50 percent effective. from The New York Times
It was a triple-thick desensitizing lubricated condom for guys with stamina problems. from People
We were like the first RuPaul's Drag Race, desensitizing people to alternative lifestyles. from Vice
The droop is caused by alcohol's penchant for desensitizing and slowing reaction time. from Vice
Miocic immediately got to work desensitizing Hunt's counter instincts with feints and jabs. from Vice
Mr. Lieberman led the charge in denouncing such games as desensitizing young players. from The New York Times
Media violence affects different kids in different ways, and overexposure can be desensitizing. from CNN
Mental health experts warn these live streams risk desensitizing the public and encouraging copycats. from CNBC
The Ranger Indoctrination Program is undoubtedly brutal, desensitizing infantrymen to the realities of violence. from The New York Times
Vox Lux is concerned with the desensitizing powers of idol worship, with all its relevant connections. from Hyperallergic
"You run the risk of desensitizing people of the issue," said Mark Orlando, CTO of Raytheon's cybersecurity practice. from Axios
In desensitizing your own audience to just how bad these actions are, because they are starting to feel absurd. from Vice
As Mr. Gibson notes, euphemisms have been invading the headlines, desensitizing the public to the tragedy of gun violence. from The New York Times
But it feels like repeatedly poking fun at and desensitizing actual tragedies and abusive behavior is a line we're crossing needlessly. from Mashable
Reproducing and repurposing brutal visuals carries the risk of desensitizing, and further reinforcing the terrorizing normalization of what shouldn't be mundane. from Hyperallergic
Then he told us what he had learned from training soldiers, from desensitizing them to their natural aversion to killing up close. from The New York Times
I've written before about how lynching photos extend into present day's shareable media incarnations of anti-Black violence, which are disseminated and desensitizing. from Hyperallergic
But too much of that would probably be desensitizing to sex in real life," he speculates, "because that's not how real sex works. from Mashable
Also, many pets are scared by loud noises — The New York Times Well Blog lists numerous remedies and suggestions for desensitizing your pet. 5. from People
Desensitizing the public The President's proclamation that he can pardon himself is raising the ante on the media circus surrounding his pardons for others. from CNN
The optimal solution, vets say, is catching the response early, and desensitizing the dog with calibrated recordings of the offending noise, and positive conditioning. from The New York Times
If we do, we might even run the risk of desensitizing people, who will end up taking this issue less seriously than they should. from Vice
So the key to desensitizing the aryl hydrocarbon receptor was probably already present inside killifish DNA, and natural selection simply brought it to the fore. from Wired
Natalie Portman stars as a pop star who survived a school shooting in director Brady Corbet's new film about the desensitizing powers of idol worship. from Hyperallergic
Donald Trump believes video games are partly to blame for the mass shootings in America -- claiming the "glorification of violence" is desensitizing potential real-life killers. from TMZ
We caught up with Brüggemann to talk about the Western adage that "ignorance is bliss" and how traditional forms of photojournalism are desensitizing us and ruining everything. from Vice
Therapists use it to treat P.T.S.D. and phobias by exposing patients to their worst fears in controlled doses, eventually desensitizing them to whatever is causing their anxiety. from New Yorker
We're berated with desensitizing information all the time, but try your best to be kind and come from a place of unconditional love, because that's all that matters. from Vice
But by experiment's end, the toothpastes branded as either anti-erosive or desensitizing failed to prevent erosion significantly better than the plain one (Colgate Cavity Protection) the researchers used. from Gizmodo
McCarthy's work can be understood not only as a direct response to the desensitizing effects of technology, but also to the dehumanizing attitudes of big tech companies at large. from Hyperallergic
They mulled over the importance of grief, of not shying away from or desensitizing the pain, of what the Parkland shooting survivors did, and why the community needs this production. from Buzzfeed News
The clumsy foreshadowing notwithstanding, the scene's anticlimactic nature exposes a fundamental paradox of the show: The stakes of the series' very first scene were possibly too high, and thus desensitizing. from The New York Times
By exclusively focusing on nameless extras being burned alive over and over again, "The Bells" dehumanized the citizens of King's Landing, desensitizing and numbing viewers to their tragic loss of life. from Mashable
In a video, Gilbert explained that what made his "delay spray" new and different was a formula that allowed lidocaine to be absorbed under a man's skin without desensitizing his partner. from CNBC
I don't think violent imagery is the sole cause of people being violent, but I'd be lying if I said I didn't think it had at least some influence in desensitizing us. from Vice
If Trump's racism, sexism, general bigotry, loose talk about democratic norms, and so on were really desensitizing Americans and permanently altering US norms, why do so many Americans appear to despise the man? from Vox
Those who have developed and fine-tuned the system know that figure rarely bears much relation to the price they will be quoted once soccer's transfer window — that dizzying, desensitizing biannual bazaar — opens for business. from The New York Times
Experts told BuzzFeed News the recent uptick is likely due to the amount of attention the attacks get and the fixation on the people behind them, spurring copycats while at the same time desensitizing the public. from Buzzfeed News
But beating that damaged deep tissue into submission has a desensitizing effect, and if you've ever tried a cheap As Seen On TV massager on back knots, you know it takes some oomph to feel anything. from Mashable
If you find that they don't work for you, or you just aren't comfortable with the idea of desensitizing your penis in the first place, other self-help options include Kegel exercises and the stop-start technique. from Vice
So in the case of Trump, the sheer number of sexual misconduct allegations seems to have had a desensitizing effect, with the press and the public beginning to treat an account of sexual assault by the US commander-in-chief as simply business as usual. from Vox
On the one hand, is there a risk of desensitizing, especially younger people perhaps; on the other hand, if they're not actually interacting in real life, then maybe these sorts of performances or acts aren't happening in real life, which is the other side of it. from Vox
In his June 1 op-ed ("Kathy Griffin's distasteful act reflects media's war on Trump") for The Hill, Bill O'Reilly chastised the "left wing national media" for desensitizing Americans to the point that they can't tell right from wrong, using the recent Kathy Griffin photo controversy as its basis. from The Hill
For this reason, while further studies would certainly be welcomed, very few clinical psychologists consider it to be a valid therapy, and are more likely to suggest a proven approach, such as Eye Motion Desensitizing and Reprocessing (EMDR) for patients suffering distress in association with particular memories, circumstances, or experiences. from Vice
The idea of oral immunotherapy dates back to 1908, when a British doctor first reported desensitizing a child with an egg allergy to eggs by giving him small amounts of egg to eat over time, said Dr. Brian P. Vickery, the lead author of the paper, who was the lead scientist for the study and an employee of Aimmune Therapeutics while the trial was being carried out. from The New York Times
Avoidance of the trigger of anaphylaxis is recommended. In cases where this may not be possible, desensitization may be an option. Immunotherapy with Hymenoptera venoms is effective at desensitizing 80–90% of adults and 98% of children against allergies to bees, wasps, hornets, yellowjackets, and fire ants. Oral immunotherapy may be effective at desensitizing some people to certain food including milk, eggs, nuts and peanuts; however, adverse effects are common.
At this temperature, nitroglycerin freezes, contracting upon solidification. Thawing it out can be extremely sensitizing, especially if impurities are present or the warming is too rapid. Chemically "desensitizing" nitroglycerin is possible to a point where it can be considered about as "safe" as modern high explosives, such as by the addition of roughly 10 to 30% ethanol, acetone, or dinitrotoluene (the percentage varies with the desensitizing agent used). Desensitization requires extra effort to reconstitute the "pure" product.
The rapidly activating, desensitizing, inward current is predominantly carried by sodium and potassium ions. 5-HT3 receptors have a negligible permeability to anions. They are most closely related by homology to the nicotinic acetylcholine receptor.
Beta arrestin is important for ceasing the response of a receptor to a stimuli. Beta arrestin also brings with it other proteins that internalize the receptor which also helps in desensitizing the cell to the stimuli.
Prenoxdiazine (marketed as Libexin) is a cough suppressant. It acts peripherally by desensitizing the pulmonary stretch receptors. Therefore, there's a reduction of cough impulses originating in the lungs. Prenoxdiazine is indicated in cough of bronchial origin.
In 2020 Zoe Rosenberg launched a Youth Activism Campaign against the animal agriculture practices of 4-H and FFA on behalf of animals, arguing that by teaching kids to raise animals for slaughter, these organizations are desensitizing youth to the pain and suffering of non-human sentient creatures.
These products, DenClude and ProClude were sold to Colgate Palmolive in 2008. ProClude, is now called Colgate Sensitive Pro Relief Desensitizing Paste with Pro Argin Technology.Colgate Sensitive Pro- Relief, "Colgate Professional", 2013 The company is also in late stage development of an electronic early cavity detector, called the Ortek ECD.
The enzyme beta glucuronidase appears to potentiate the desensitizing effect of a small dose of allergen. The quantities of both are smaller than those occurring naturally in the body, but not so small that they can be regarded as homeopathic. Intradermal injections are used. The treatment takes 3–4 weeks before any effect is seen.
Lax, haunted by his own past, is now face to face with Herman. Herman is executed in the electric chair. The movie explores why and how a massacre like this can happen in our society, desensitizing in America, youth violence and bullying, the impact the media has on our individual quest for fame, and ultimately our need for connection.
Dessirier et al., 2001, also claim the cross-desensitization of menthol receptors can occur by unknown molecular mechanisms, though they hypothesize the importance of Ca2+ in reducing cell excitability in a way similar to that in the capsaicin receptor. Mutagenesis of protein kinase C phosphorylation sites in TRPM8 (wild type serines and threonines replaced by alanine in mutants) reduces the desensitizing response.
This is unlike orthosteric drugs, which tend to produce a less targeted effect within body on all of the receptors they can bind to. Some modulators have also been shown to lack the desensitizing effect that some agonists have. Nicotinic acetylcholine receptors, for example, quickly desensitize in the presence of agonist drugs, but maintain normal function in the presence of PAMs.
This differs from acetylcholine, which is rapidly degraded and only transiently depolarizes the muscle. There are two phases to the depolarizing block. During phase I (depolarizing phase), they cause muscular fasciculations (muscle twitches) while they are depolarizing the muscle fibers. Eventually, after sufficient depolarization has occurred, phase II (desensitizing phase) sets in and the muscle is no longer responsive to acetylcholine released by the motoneurons.
Tar is the common name for the resinous, partially combusted particulate matter made by the burning of tobacco and other plant material in the act of smoking. Tar is toxic and damages the smoker's lungs over time through various biochemical and mechanical processes. Tar also damages the mouth by rotting and blackening teeth, damaging gums, and desensitizing taste buds. Tar includes the majority of mutagenic and carcinogenic agents in tobacco smoke.
Cosmetic or functional intervention may be required if tooth surface loss is pathological or if there has been advanced loss of tooth structure. The first stage of treatment involves managing any associated conditions, such as fractured teeth or sharp cusps or incisal edges. These can be resolved by restoring and polishing sharp cusps. Then, desensitizing agents such as topical fluoride varnishes can be applied, and at home desensitising toothpastes recommended.
This type of block occurs when the desensitizing phase sets in and the muscle is no longer responsive to acetylcholine and full neuromuscular blockade is achieved. TOF fade is indicative of phase II block that is likely to occur in patients who received succinylcholine and may resemble features of a nondepolarizing block. During phase II, reversal with neostigmine should not be attempted. Anticholinesterase agents can worsen paralysis in this setting.
Pharmacodynamic tolerance begins when the cellular response to a substance is reduced with repeated use. A common cause of pharmacodynamic tolerance is high concentrations of a substance constantly binding with the receptor, desensitizing it through constant interaction. Other possibilities include a reduction in receptor density (usually associated with receptor agonists), or other mechanisms leading to changes in action potential firing rate. Pharmacodynamic tolerance to a receptor antagonist involves the reverse, i.e.
Many topical treatments for dentin hypersensitivity are available, including desensitizing toothpastes and protective varnishes that coat the exposed dentin surface. Treatment of the root cause is critical, as topical measures are typically short lasting. Over time, the pulp usually adapts by producing new layers of dentin inside the pulp chamber called tertiary dentin, increasing the thickness between the pulp and the exposed dentin surface and lessening the hypersensitivity.
Govt efforts key to desensitizing religious management, Global Times The church had been registered with the government authorities. The demolition was preceded by a petition by local believers of the Chinese folk faith accusing the church to disrupt the area's feng shui (cosmic harmony), highlighting the tensions between indigenous religious groups and Christianity.Razing of church stuns Christians in China. On International New York Times, Friday, May 30, 2014.
In 2015, flibanserin was approved in the US to treat decreased sexual desire in women. While it's effective for some women, it has been criticized for its limited efficacy, and many warnings and contraindications that limit its use. name=WebMD Women experiencing pain with intercourse are often prescribed pain relievers or desensitizing agents; others can be prescribed vaginal lubricants. Many women with sexual dysfunction are also referred to a counselor or sex therapist.
It is more potent than capsaicin and is currently in development as a sensory neuron desensitizing agent. Initially, agonists were the major focus of the TRPV1 ligand development due to the analgesic effect resulting from desensitization of the receptor. However, because of an initial burning effect of all natural vanilloid receptor agonists, including capsaicin, therapy becomes complicated and perhaps ineffective. Attempts to make synthetic agonists with good separation between excitatory effects and the analgesic effects have not been successful.
Another treatment option is the topical solution of cocaine HCl which also provides relief for a short time period by acting as an anesthetic and desensitizing the nasal neurons. The topical solution is applied on the nostril. This topical solution can have several side effects as it has been found that some patients suffering from troposmia started to show symptoms of phantosmia after its use. Other patients have lost complete function of the nostril where the drug was applied.
Of these, Q50R and G159D co- segregated with disease in affected family members, increasing confidence that they are clinically significant mutations. The biochemical consequences of thin filament DCM-associated mutations are less well established than for HCM, although there has been some suggestion that some of the mutations abolish the calcium desensitizing effect of cTnI phosphorylation at Ser22/23. This may be because some mutations disrupt the precise positioning of cNTnC for triggering muscle contraction when cTnI is unphosphorylated.
The institute provides 80,000 dialyses each year. In addition to traditional hemodialysis, The Rogosin Institute offers patients a number of options, including peritoneal dialysis and home nocturnal hemodialysis. Dialysis centers are located in Manhattan, Brooklyn, and Queens. The Rogosin Institute is a pioneer in the implementation of technologies that make kidney transplantation more accessible and successful, such as programs for highly sensitized transplant recipients, the use of steroid-free protocols, desensitizing programs for incompatible donors, and donor exchange programs.
Sorrento Therapeutics has been developing RTX as a means to provide pain relief for forms of advanced cancer. The nerve desensitizing properties of RTX were once thought to be useful to treat overactive bladder (OAB) by preventing the bladder from transmitting “sensations of urgency” to the brain, similar to how they can prevent nerves from transmitting signals of pain; RTX has never received FDA approval for this use. RTX has also previously been investigated as a treatment for interstitial cystitis, rhinitis, and lifelong premature ejaculation (PE).
There are many applications of inhibitory postsynaptic potentials to the real world. Drugs that affect the actions of the neurotransmitter can treat neurological and psychological disorders through different combinations of types of receptors, G-proteins, and ion channels in postsynaptic neurons. For example, studies researching opioid receptor-mediated receptor desensitizing and trafficking in the locus cereleus of the brain are being performed. When a high concentration of agonist is applied for an extended amount of time (fifteen minutes or more), hyperpolarization peaks and then decreases.
On October 20, 2010, Chesser pleaded guilty to three felonies: communicating threats to Parker and Stone, soliciting violent jihadists to "desensitize" law enforcement, and attempting to provide material support to a designated foreign terrorist organization. "Desensitizing" law enforcement referred to plans to place suspicious-looking but inoffensive packages in public places, until police became lax about dealing with them, at which point a real explosive could be used. These three charges carried a maximum of 30 years in prison; Chesser's sentence was 25 years.
Her work on sociable media has applications in the field of semiotics. On the subject of telerobotics, Donath argues that the remote manipulation afforded by the discipline may act as a desensitizing agent because the identity and human characteristics of the remote subjects of the telerobotic operation remain unseen by the human teleoperator of the robot. She has also researched the ethnography of online communities. Her work includes the application of architectural principles to the design of the social interaction environment of online communities in a kind of virtual city.
The molecular mechanism of smooth muscle relaxation involves the enzyme CGMP-dependent protein kinase, also known as PKG. This kinase is activated by cGMP and it phosphorylates multiple targets in the smooth muscle cells, namely myosin light chain phosphatase, RhoA, IP3 receptor, phospholipase C, and others. Overall, this results in a decrease in intracellular calcium and desensitizing proteins to the effects of calcium, engendering smooth muscle relaxation. Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.
For example, the LTC6702, MAX9021 and MAX9031 have internal hysteresis desensitizing them from input noise. In place of one switching point, hysteresis introduces two: one for rising voltages, and one for falling voltages. The difference between the higher-level trip value (VTRIP+) and the lower-level trip value (VTRIP-) equals the hysteresis voltage (VHYST). If the comparator does not have internal hysteresis or if the input noise is greater than the internal hysteresis then an external hysteresis network can be built using positive feedback from the output to the non-inverting input of the comparator.
The expression condenses three principles:the first supposition is that informational excess could lead to a tragic numbness and social detachment. It has to do with the social risks associated with technology use, namely, the threat of desensitizing the individual’s awareness by means of a surplus of means of communication. The second assumption relies on the assertion that to know is the same as to act. The narcotizing dysfunction draws attention to the fact that individuals tend to consider that because they are informed about a subject, they are necessarily concerned with it—as if there was a correspondence between information and political commitment.
Some theorists charge that the acceptance of these sexual practices increase sexual violence against women, by reinforcing stereotypical views about women, who are seen as sex objects which can be used and abused by men, and by desensitizing men; this being one of the reasons why some theorists oppose the sex industry. They argue that pornography eroticizes the domination, humiliation, and coercion of women, and reinforces sexual and cultural attitudes that are complicit in rape and sexual harassment. The anti- pornography feminist, Andrea Dworkin, has famously argued this point in her controversial Pornography: Men Possessing Women (1981).
Desensitizing an otherwise trained horse to accept the fluttering skirt of a lady's riding habit. :The phrase "sack out" also refers to going to sleep. Sacking out is a method used by horse trainers to desensitize a horse to potentially frightening situations or objects. It is a process that, done properly, teaches a horse to not fear certain objects or situations, and, over time can be used to teach a horse to stop and listen to its handler in any potentially frightening situation, thus, in effect, to assess the situation instead of immediately acting upon its fight or flight instinct.
Harris and Barlett concluded that a few studies have developed extensive pre-exposure training and/or post-exposure debriefing procedures to lessen the desensitizing effects. Linz found that by offering pertinent educational information about rape myths reduced the effect of desensitization, which means experimental participation can also help reduce the rape myth acceptance. Wilson, Linz, Donnerstein, and Stipp conducted a field experiment, they found that men who are older than 50 had preexisting attitudes reinforced and actually blamed women for rape after seeing the film. In other words, preexisting attitudes and personal experience should be considered when conducting research studies.
Its formula of 5% glutaraldehyde and 35% HEMA (hydroxyethyl methacrylate) in waterHeraeus-Kulzer: GLUMA is used to help control both hypersensitive dentin and reduce the incidence of post-operative sensitivity in restorative dentistry procedures. It’s also useful as a cavity disinfectant, a rewetting agent and an adhesion promoter (when combined with most dentin bonding systems). Research indicates that when used as a desensitizer under bonded restorative material, Gluma has no significant influence on bond strength, unlike some other liners, which contribute to a decrease in bond strength.Kobler, A; Schaller, HG; Gernhardt, CR: Effects of the desensitizing agents Gluma and Hyposen on the tensile bond strength of dentin adhesives.
" She described Ranaut's work as "Kangana's lack of vanity onscreen is among her many strengths. She isn't afraid to look unattractive or behave badly." From Rediff.com, Vaihayasi Pande Daniel gave Simran 3 out of 5 stars "Simran is a light-hearted, time-pass film not attempting to explore any higher themes." Pointing to some contrivances Kunal Gupta of Mumbai Mirror gave 2.5 out of 5 stars slating the film's casual tone as distracting and desensitizing during the crime scenes. Umesh Punwani from Koimoi declared "Simran is all about Kangana Ranaut, 5 minutes into the film and you know this is going to be special.
An example of the need for desensitizing training is when an object, such as a plastic bag, suddenly blows across the path of horse and rider, which, if the horse has not been properly desensitized, could result in spooking. Spooking is potentially dangerous, as it can result in fallen riders or horses bolting into danger. Another example would be the need to desensitize a horse to the sound of traffic, music, loudspeakers and other stimuli seen at public events. In some cases, a previous bad experience may have given a horse reason to fear a specific situation, requiring a form of systematic desensitization to gradually overcome its fear.
While experimenting on subatomic particles, a team of physics researchers start a chain reaction that seemingly controls the researchers themselves. As one scientist after another is consumed and turned into nuclear 'zombies' by what seems to be a form of sentient particles from another dimension, the reaction grows towards a terrible climax, and the survivors fear they may be powerless to stop it. Just as the ever-expanding particles are about to engulf the lab and explode into an atomic cataclysm that could destroy the world, the head of the research facility calculates a formula to reverse the effects of the reaction, incorporates a random element, and succeeds in desensitizing the new lifeform, rendering it powerless.
Another problem with wearing a splint can be stimulation of salivary flow, and for this reason some advise to start wearing the splint about 30 mins before going to bed so this does not lead to difficulty falling asleep. As an added measure for hypersensitive teeth in bruxism, desensitizing toothpastes (e.g. containing strontium chloride) can be applied initially inside the splint so the material is in contact with the teeth all night. This can be continued until there is only a normal level of sensitivity from the teeth, although it should be remembered that sensitivity to thermal stimuli is also a symptom of pulpitis, and may indicate the presence of tooth decay rather than merely hypersensitive teeth.
He is best known for his work on heterologous down-regulation of EGF receptor by NGF, which would appear to be an efficient mean of desensitizing the neurons to proliferative signals. Lazarovici pursued neuroscience as a visiting associate in the Section on Growth Factors at National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA. After completion of his research, he joined as Lecturer in The School of Pharmacy, The Hebrew University of Jerusalem and later he became the full Professor. He is an active member of the Israel Societies for Physiology and Pharmacology (ISPP), and Neuroscience (ISN), American Societies for Neuroscience (ASN), and Pharmacology and Experimental Therapeutics (ASPET). Lazarovici was part of the Israeli group developing with TEVA Co. the drug for Parkinson’s named Rasagiline (Azilect).
Fel d1 is a protein primarily found in cat saliva and sebaceous glands. Those with cat allergies may react worse to direct contact with Sphynx cats than other breeds; even though reports exist that some people with allergies successfully tolerate Sphynx cats, they are fewer than those who have allergic reactions, according to David Rosenstreich, MD, the director of the Division of Allergy and Immunology at the Albert Einstein College of Medicine and Montefiore Medical Center in the Bronx, New York City, New York. These positive reports may be cases of desensitizing, wherein the "hairless" cat gave the owner optimism to try to own a cat, eventually leading to the positive situation of their own adaptation. Sphynx cats can also have more ear wax than most hairy domestic cats because they have little to no hair in their ears.
His work, when sold in galleries, can fetch six-figure sums. Hong Kong Phooey (HK 58), sold for US$250,000 in early 2015 Fellow street artist Shepard Fairey wrote in Swindle: > Invader's pop art may seem shallow, but by taking the risk of illegally re- > contextualizing video game characters in an urban environment that provides > more chaotic social interaction than a gamer's bedroom, he makes a statement > about the desensitizing nature of video games and consumer culture. In a > postmodern paradox, a game like Grand Theft Auto takes the danger of the > streets and puts it in a safe video game, while Invader takes a safe video > game icon and inserts it into the danger of the streets. During an early 2014 "invasion" in Hong Kong comprising a total of 48 works, the city's Highways Department removed the life-sized Hong Kong Phooey (HK 58) mosaic, which had been placed by the side of a road in Fortress Hill.
Slap the Monster on Page One (Italian: Sbatti il mostro in prima pagina) is a 1972 Italian drama film directed by Marco Bellocchio. It depicts the daily life of a fictitious Italian daily newspaper Il Giornale (The Journal). The newspaper caters to a conservative, fascist, borgeouis public and its chief- editor Bizanti tries in all manners to give a right-wing slant even to the most trivial news items, while at the same time edulcorating and desensitizing the thornier issues, such as unemployment, police brutality and so on. The whole editorial staff is thrown in a tantrum when a young girl is found raped and killed, going as far as soliciting death penalty nostalgias (capital punishment has been abolished in Italy since the fall of Fascism) and to actually derail the investigation leading the police to a false culprit: a young left-wing student which becomes the "ideal" scapegoat for the newspaper's prejudiced readership.
Benita "Benny" Diaz Lopez (Belita Moreno) is George and Linda's mother, Angie's mother-in-law, and Carmen and Max's paternal grandmother; a wise-cracking, outspoken, insensitive alcoholic who was responsible for George's frequently-mentioned traumatic childhood. Conceiving him in the back of a car wash after engaging in premarital sexual relations with Manny Lopez, Benny wed her lover shortly afterward, only for Manny to divorce her during George's infanthood. After convincing George that his father had died, Benny showed her son an abusive, dysfunctional home life and childhood, desensitizing him to her constant criminal actions as if they were any normal occurrences, guarding numerous other secrets from her son as well that were unveiled during his adulthood. Many episode plots had often been established through George's discovery of a protected secret, such as the revelation of his having a sister named Linda (who had enjoyed a far more loving childhood after Benny had given her up for adoption), and many jokes had been brought up referencing one of Benny's numerous acts of child abuse directed toward George and mistreatment of him.