"I think confirmatory thinking (confirmatory bias) is the most common, and impactful, bias that we have uncovered," said Payne.
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"We will do a confirmatory search tomorrow morning," Kumar said.
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An amendment to add a confirmatory referendum seems unlikely to succeed.
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We do have a confirmatory trial for Exondys ongoing right now.
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This is also known as a "people's vote" or confirmatory public vote.
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It also said that the due diligence would be "confirmatory in nature".
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There's publication bias — the trend that journals only publish positive, confirmatory results.
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Pylori infection * Plan to initiate rhb-105 confirmatory phase iii study discussed with fda during second half of 2016 * Will complete a supportive pharmacokinetic (pk) program prior to initiating confirmatory phase iii study in second half of 2016.
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But a second referendum — or confirmatory vote, as it's called — is very tricky.
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Corbyn has insisted that May agree to a confirmatory referendum on any deal.
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You enhance the chances of winning the bet by doing a confirmatory biopsy.
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Confirmatory lab testing is pending at the Centers for Disease Control and Prevention.
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Additional confirmatory testing will need to be done, as well as genetic counseling.
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Its continued approval may depend on verification of clinical benefit in a confirmatory trial.
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A "confirmatory public vote" remains part of the Brexit discussions between Corbyn and May.
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It does not require a confirmatory ballot on any deal that meets those conditions.
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She wants me to come down to their office today for a confirmatory blood draw.
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Continued approval for the treatment may depend on data from a confirmatory trial, Roche said.
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He said an agenda had been circulated that included the idea of a confirmatory referendum.
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That's common in poor countries, where it is often impossible to get confirmatory X-rays.
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They are enrolling patients for a confirmatory late-stage trial testing the drug against standard chemotherapy.
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Whilst the non-binding offer is still subject to confirmatory due diligence and a binding contract.
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The government is opposed to a confirmatory referendum and therefore we would not be supporting it.
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"We were surprised by our results because we found that most of those drugs were actually improving only a surrogate measure even in confirmatory trials -- and often times, it was the same surrogate endpoint tested in confirmatory trial that was used for accelerated approval," Gyawali said.
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Stay tuned to future research and recommendations that will come out when the studies are more confirmatory.
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The companies are enrolling patients for a confirmatory late-stage trial testing the drug against standard chemotherapy.
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Corbyn said he would now back a confirmatory referendum on the U.K.'s exit from the bloc.
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The drug's continued approval for this indication may be contingent upon the results of confirmatory trials, Merck said.
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A proposal for a confirmatory referendum on any deal got the most votes, but was defeated 292-280.
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These cases are pending confirmatory testing from the US Centers for Disease Control and Prevention, the release said.
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So if anything does come up, you still have to go see a doctor for confirmatory clinical testing.
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"So the confirmatory trials were not confirming clinical benefit but actually confirming benefit in a surrogate endpoint," he said.
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A vocal proponent of a second confirmatory referendum, Grieve is also an advocate for greater parliamentary control over Brexit.
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A proposal for a confirmatory referendum on any deal got the most votes, but was defeated by 292-280.
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It specifically refers to the subset of patients who had an irregular pulse notification while wearing their confirmatory patch.
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Positive, confirmatory findings often make their way into the published literature, while negative findings collect dust in file drawers.
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They also took a close look at data on surrogate endpoints used in preapproval and confirmatory trials of those drugs.
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If a confirmatory trial shows the drug does confer such a benefit, the FDA grants full approval for the drug.
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A confirmatory trial called Paloma-2 studied the treatment with letrozole, which reduces estrogen production, in 666 post-menopausal women.
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Accordingly, unless you and we agree on mutual confirmatory due diligence to support a friendly combination by 173:00 p.m.
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Accordingly, unless you and we agree on mutual confirmatory due diligence to support a friendly combination by 5:00 p.m.
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A proposal to hold a confirmatory referendum on any deal got the most votes, but was defeated by 292-280.
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"I also raised the prospect of a confirmatory vote," he said, meaning a public vote seeking approval of any deal.
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"This brings the prospect of a confirmatory referendum closer, although there's not yet a majority for that in parliament," he added.
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Parliament has discussed such a confirmatory vote, which would put the Brexit deal (first May's, now Johnson's) back to the people.
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A second referendum, or "confirmatory public vote" as it's also being called, would put the Brexit question back to the people.
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This option stipulates that any Brexit deal approved by Parliament has to go back to the public for a "confirmatory" vote.
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"This was really, in large part, a 'he said, she said' - there was very, very little confirmatory evidence," Greenspon told Reuters.
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The researchers found that only 19 of those drug uses ended up demonstrating improvements in overall patient survival in subsequent confirmatory trials.
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One of the people said that, before final bids, the suitors may be asked for confirmatory offers in a couple of weeks.
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She said most doctors would send the confirmatory venous blood sample out of the office for analysis by a different testing system.
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Some MPs (Members of Parliament) will likely try to amend the bill this week to make sure there is a "confirmatory" referendum.
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But it would be no triumph of democracy if it were pushed through without first being put to a confirmatory popular vote.
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But you have to do a confirmatory study of your first drug because you got conditional approval from it from the FDA.
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"The important message is that this data is certainly supportive of the confirmatory phase 3 study that we have already underway," Torley said.
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A large number of MPs looked favourably on the idea that any deal approved by Parliament should be put to a confirmatory referendum.
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Despite the two confirmed infections, eight of the cases are still being investigated and four confirmatory tests are pending, the Associated Press reported.
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The company, which is still awaiting overall survival data, said keeping the regulator's blessing may depend on the results of further, confirmatory trials.
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Then, it took action upon hearing a "send message" request, the name of a friend, and finally a confirmatory "right," in that order.
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Final bids for the unit, from around two to three bidders, are expected in February following a confirmatory bids process on January 13.
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One idea is to attach a confirmatory referendum to some version of a Brexit deal, which might win over a majority of MPs.
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A "confirmatory" referendum could also be attached to the Brexit bill at a later date and doesn't necessarily have to pass on Saturday.
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Within both parties there are deep divides over any joint plan, with a growing chorus calling for a second "confirmatory" referendum on any deal.
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"This House must also consider whether any deal should be put to the people for a confirmatory vote," he told parliament after the votes.
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The FDA recommends using confirmatory testing, which is more costly and takes longer but can "obtain a confirmed analytical result" by identifying specific substances.
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The Labour leader said that he would support a "confirmatory" referendum only in the event that Mrs May's deal managed to pass through Parliament.
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The agency requested that Sarepta provide dystrophin data from biopsies already obtained from the ongoing confirmatory study of eteplirsen, the company said on Monday.
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Due to a phenomenon called confirmatory bias, we're much more likely to notice things that confirm our beliefs than those we don't believe in.
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Mr. Johnson's critics would like to attach amendments to his plan, particularly a confirmatory referendum or keeping Britain in the European Union customs territory.
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The study has "confirmatory value that cataract surgery and cataract surgery in both eyes, works," added Sugar, who also wasn't involved in the research.
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"And I think this brings the prospect of a confirmatory referendum closer although there's not yet a majority for that in parliament," he said.
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Dr. Janet Woodcock, the head of the FDA's pharmaceuticals division, appeared willing from the beginning to support approval pending the outcome of a confirmatory trial.
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Detectives travelled to Texas to interview McFadden's family members and obtain a confirmatory DNA standard to compare with the DNA evidence in the Hlavka murder.
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People's next steps should include following up with a health-care provider or reaching out to a genetic counselor to pursue confirmatory testing, she added.
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The newspaper said May discussed the idea of offering to put her deal to a confirmatory public vote with some of her ministers on Monday.
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He had directed the bureau to conduct further confirmatory laboratory tests, including sending blood samples to foreign laboratories, to determine the cause of the pigs' deaths.
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The outcome of any election is uncertain and while both main parties' manifestos support Brexit, the opposition Labour Party backs a "confirmatory referendum" on any deal.
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Without the availability of confirmatory HIV testing, he had no choice but to wait and see if he developed symptoms -- and in the meantime, soldier on.
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A customs-union motion was rejected by just three votes; a confirmatory referendum by 12; and a "Norway-plus" option redubbed "Common Market 2.0" by 21 votes.
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"After signing and entering into the confirmatory diligence phase, we have received disappointing information about the viability of completing this transaction," Contreras-Sweet said in the statement.
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In an unusual move, bidders were asked to use the staple financing offered by M&A advisers Deutsche Bank, Goldman Sachs and JP Morgan for confirmatory bids.
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Because of the potential for cross-reactivity, positive serology results are tested again with a more sensitive, confirmatory test called a plaque reduction neutralization test or PRNT.
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One route is through a Labour victory at an election; while Corbyn has talked vaguely about a 'confirmatory referendum', his party is clear it wants a second vote.
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"This (positive data on golodirsen) reduces any uncertainty around the efficacy of Exondys 51 and decreases any risk around the pending confirmatory study," Needham analyst Chad Messer said.
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Researchers at Walter Reed National Military Medical Center, who did the confirmatory tests, reported on the Pennsylvania case Thursday in a journal of the American Society of Microbiology.
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Confirmatory tests were only able to determine that the women had been recently infected with a flavivirus, a family of viruses that includes Zika, dengue and yellow fever.
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The other big problem is that it adds a confirmatory finding to the ego depletion literature, when in actuality there's a greater chance that the study is inconclusive.
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A late-stage study, currently testing Xpovio in combination with Takeda Pharmaceutical Co Ltd's Velcade and low-dose dexamethasone, will serve as a confirmatory trial, the company said.
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But check the small print: Labour is proposing that such a referendum take place only after Parliament approves Mrs May's deal, as what Mr Corbyn calls a "confirmatory" measure.
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Opposition Labour leader Jeremy Corbyn said on Tuesday that even if May got her Brexit deal approved by parliament then it should be put to a "confirmatory" public vote.
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Seattle Genetics, which already has an approved cancer drug Adcetris, will take charge of the IMMU-132 application and the confirmatory late-stage trial, assuming the drug wins approval.
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"We know that our government's senior leaders need confirmatory data as the basis for changes to current policy," said Derek Fronabarger, a legislative director for the Wounded Warrior Project.
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This proposal for a so-called "confirmatory" public vote remains hugely popular among Labour Party supporters and is a significant plank in the negotiating position of several top Labour officials.
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LONDON (Reuters) - If Prime Minister Theresa May's Brexit deal is approved by parliament it should be put to a "confirmatory" public vote, opposition Labour leader Jeremy Corbyn said on Tuesday.
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MEG TIRRELL: What about with the accelerated approval pathway, there's the understanding that in the confirmatory studies, if those don't bear out, the drug should be pulled from the market.
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Yet many Labour MPs and candidates want to go further by campaigning for a confirmatory referendum for any Brexit deal, with the choice of remaining in the EU on the ballot.
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At Wednesday's votes on Brexit options, 27 Labour lawmakers rebelled against their party's position by voting against holding a confirmatory public vote on any Brexit deal and a further 18 abstained.
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His supporters are keen to stress that like most residents, Freer voted for Remain, and even backed a confirmatory referendum, or People's Vote, during House of Commons indicative votes in April.
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As for the other suspected cases, the CDC said: For four additional suspected sexual transmission events, preliminary laboratory evidence (IgM antibody test) is available for the women, but confirmatory tests are pending.
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Stada is expecting to receive so-called confirmatory bids from a consortium comprising Advent and Permira as well as from rivals Bain and Cinven, who have teamed up as well, on Friday.
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Labour's Brexit pointman, Keir Starmer, told The Guardian newspaper that any cross-party deal lacking a confirmatory referendum would not pass parliament as about 150 Labour lawmakers would oppose such a deal.
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When the FDA approves medicines via its Accelerated Approval pathway, he said, the agency should clearly specify the data limitations and how required confirmatory studies are expected to compensate for these limitations.
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Pylori infection at the innovations in gastroenterology 2017 symposium * Confirmatory phase iii study with rhb-105 is planned to be initiated in first half of 2017 Source text for Eikon: Further company coverage:
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Investigators have to do confirmatory DNA testing, by retrieving bits of genetic material from the suspect, usually pulled from his or her trash, and comparing them to DNA found at the crime scene.
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"Next week our priorities are clear: if Boris Johnson does manage to negotiate a deal, then we will insist that it is put back to the people in a confirmatory vote," Starmer said.
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But the Labour leader is under growing pressure to make any agreement with May conditional on holding a confirmatory referendum on the deal, or asking the public to back it in another vote.
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After the employee made that selection, "a standard, confirmatory pop-up" appeared on his computer asking whether the employee was sure he wanted to send the alert, and he confirmed that he did.
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U.K. government plans to have a straight vote Saturday on its new draft Brexit deal look set to go ahead, despite attempts by opposition MPs (Members of Parliament) to attach a "confirmatory" referendum.
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" He added that for the accelerated approval pathway to function effectively, when the drugs receiving accelerated approval fail to prove clinical benefit in confirmatory trials, "prompt action should be taken to withdraw the approval.
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The 57-year old Italian, who has chaired the rule-making European Banking Authority since 2011, touched some raw nerves for struggling lenders in his native country in his confirmatory hearing before European parliamentarians.
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Confirmatory bids are due just before Easter, sources close to the matter told Reuters, adding that some Chinese groups as well as buyout firms such as Bain Capital are expected to hand in offers.
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"Corbyn could refuse to offer a compromise acceptable to moderate Conservatives and/or insist on a confirmatory referendum in the hope of fracturing the Conservative party and trigger a snap election," the economists wrote.
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"The White House is aware of public reports that a member of the Brazilian delegation's visit to Mar-a-Lago last weekend tested positive for COVID-19; confirmatory testing is pending," the statement said.
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Not one Brexit plan has received support from a majority of MPs in tonight's #indicativevotesThe closest to get a majority were Clarke's Customs Union plan (49.2%) and Beckett's confirmatory public vote plan (47.6%) pic.twitter.
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"The White House is aware of public reports that a member of the Brazilian delegation's visit to Mar-a-Lago last weekend tested positive for COVID-19; confirmatory testing is pending," Grisham's statement said.
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Some lawmakers may yet change their minds, particularly if any referendum was a confirmatory vote on whether to back May's deal, much as Corbyn suggests, rather than a re-run of the 2016 vote.
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But the most promising is to agree as part of a cross-party deal to put the outcome to a confirmatory referendum, an idea that lost by only 12 votes in the Commons this week.
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"Wrapping any negotiated exit deal in a confirmatory second referendum may well be seen by a majority of MPs as an appealing ameliorative to the stark divisions running through the House of Commons," they said.
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While the party's Jeremy Corbyn says an election is still his priority, he appears almost completely isolated with even his closest allies defying him and pushing for a confirmatory vote on any deal Johnson brings back.
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Pro-Remain MPs hope to amend any motion put by the government to insist that Johnson's deal is put to a confirmatory vote, with the option to remain in the EU also on the ballot paper.
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While we wait for the CDC to conduct their confirmatory testing, the Department of Health staff is working to identify additional people who came in close contact with these individuals to decrease the spread of illness.
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The deputy political editor of the Telegraph newspaper, Steven Swinford, said Labour and the Conservative government were still discussing both a customs union and the idea of holding a confirmatory referendum on any deal they agree.
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"I predict FDA will remove the drug from the market, since the confirmatory trial showed no benefit, and removing the drug does not necessarily completely eliminate the opportunity for some women to receive the therapy," Gellad said.
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McCormick said it was willing to proceed with "limited confirmatory due diligence" and that it was "disappointed" that Premier's board was "conducting itself in a way that denies Premier Foods' shareholders the opportunity to consider" its offer.
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Finance minister Philip Hammond said that if talks with Labour failed, the government would try to take ideas from the discussions and present them to parliament, adding a confirmatory vote idea deserved to be tested in parliament.
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With little sign of an end to the standoff, Corbyn is under increasing pressure to throw his support behind a second referendum, or confirmatory vote, on any Brexit deal, but he has so far failed to move.
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BRITAIN STILL DIVIDED Some lawmakers may yet change their minds, particularly if any referendum was a confirmatory vote on whether to back May's deal, much as Corbyn suggests, rather than a re-run of the 2016 vote.
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SCOTT GOTTLIEB: And we have pulled drugs from the market that have been improved on an accelerated approval basis, and we've also sanctioned companies that weren't moving quickly enough to try to get those confirmatory studies done.
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LONDON (Reuters) - Theresa May's government is drafting a letter to the opposition Labour Party that could suggest allowing lawmakers to decide whether there should be a confirmatory referendum on any Brexit deal, the Guardian reported on Thursday.
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The Daily Telegraph reported earlier this week that May was considering offering lawmakers a vote on whether to hold a confirmatory public vote on her Brexit deal in a bid to resolve the impasse holding up parliamentary ratification.
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At the Open Public Hearing, the trial data was further bolstered by compelling testimonials from boys receiving eteplirsen in the ongoing 5 year trial and on the already initiated confirmatory trials, as well as their parents and supporters.
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"Parliament has no appetite for a no-deal Brexit or no Brexit … I can see a center of gravity emerging in Parliament where it's towards a customs union perhaps with a confirmatory vote," he told CNBC's "Capital Connection" Tuesday.
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"If a deal like that is offered we will amend it so it can only come into effect after a confirmatory referendum in which the options would be to leave on those terms or Remain," he told the Observer.
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"Accelerated approval makes this drug available to patients based on initial data, but we eagerly await learning more about the efficacy of this drug through a confirmatory clinical trial that the company must conduct after approval," the FDA said.
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Half of May's lawmakers voted in favor of a 'no deal' Brexit when parliament voted on alternative Brexit options last week, while 34 supported seeking a customs union with the EU and eight backed a confirmatory public vote on any deal.
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Half of May's lawmakers voted in favour of a 'no deal' Brexit when parliament voted on alternative Brexit options last week, while 34 supported seeking a customs union with the EU and eight backed a confirmatory public vote on any deal.
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Tagrisso is already on the market, winning early approval based on mid-stage studies and selling $276 million in the first nine months of 103, but AstraZeneca was required to produce a confirmatory Phase III randomized study detailing its benefits.
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Tagrisso is already on the market, winning early approval based on mid-stage studies and selling $276 million in the first nine months of 2016, but AstraZeneca was required to produce a confirmatory Phase III randomised study detailing its benefits.
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LONDON (Reuters) - Britain's opposition Labour Party will vote in favor of three alternative Brexit options in parliament on Monday, including a proposal for a customs union and one for a confirmatory referendum on any deal, its Brexit spokesman Keir Starmer said.
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The Daily Telegraph reported earlier this week that May was considering offering lawmakers a vote on whether to hold a confirmatory public vote on her Brexit deal in a bid to break the deadlock in talks with the opposition Labour Party.
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Dr. Janet Woodcock, director of the F.D.A.'s Center for Drug Evaluation and Research, said in a statement, "We eagerly await learning more about the efficacy of this drug through a confirmatory clinical trial that the company must conduct after approval."
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The Daily Telegraph reported earlier this week that Prime Minister Theresa May was considering offering lawmakers a vote on whether to hold a confirmatory public vote on her Brexit deal in a bid to break the deadlock in talks with Labour.
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BOY IN WHEELCHAIR PULLS HIMSELF TO FEET FOR NATIONAL ANTHEM AT TENNESSEE FAIR "Transylvania Public Health (TPH) has received confirmatory laboratory tests from the N.C. State Laboratory of Public Health," TPH spokesperson Tara Rybka told the outlet on August 3.
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CK is an enzyme associated with muscle damage and patients with DMD uniformly exhibit high levels of CK. Indeed, significantly elevated CK is often used as a preliminary diagnosis tool for DMD, which is then followed by confirmatory genetic testing.
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Mr. Fender then tracked down Jill Goldman, a genetic counselor specializing in dementia at the Taub Institute at Columbia University Medical Center, who described a multistep process of counseling and confirmatory testing that's been the standard of care for 260 years.
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A spokesman for the party said Labour will back two motions that support Britain participating in a post-Brexit customs union with the EU, another which backs a confirmatory public vote to approve any final Brexit deal, and its own proposed Brexit deal.
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Lilly also cited a number of other near-term challenges it faces, such as cheap generic competition for erectile dysfunction treatment Cialis and the recent global withdrawal of cancer drug Lartruvo after it failed to prove its benefit in a confirmatory clinical trial.
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Mays government is trying to convince the Labour Party to back her deal but Labour wants to keep Britain in a customs union with the EU and has been discussing the idea of holding a confirmatory referendum on any deal they agree.
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These were an amendment sponsored by Kenneth Clarke, a Tory veteran, to add a permanent customs union to her deal; and a motion from Margaret Beckett, a former Labour foreign secretary, to put any deal approved by MPs to a confirmatory referendum.
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LONDON (Reuters) - Prime Minister Theresa May and Labour are yet to agree whether a customs union or confirmatory public vote would be part of a compromise deal to win the opposition party's support for a Brexit deal, the Telegraph's deputy political editor reported.
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Lilly on Wednesday also cut its 2019 profit and revenue forecasts to account for disappearing sales of its cancer drug Lartruvo, which won conditional U.S. approval in 1.33 based on early data but last month failed to extend patient survival a confirmatory trial.
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Lawmakers failed on Monday to find a majority of their own for any alternative plan ranging from a permanent customs union to a confirmatory referendum on any deal and a revocation of the divorce papers to avoid a no-deal crash-out.
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The new study, published in the medical journal JAMA Internal Medicine on Tuesday, found that among cancer drugs that received accelerated approval from the FDA using surrogate endpoints or other measures, only one-fifth ended up improving overall survival rates in later confirmatory trials.
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There is a narrow chance May could untie the knot herself, perhaps through a proposal from two Labour MPs to subject the withdrawal agreement to a "confirmatory vote": If approved by the electorate, it would come into effect, perhaps one month after the public vote.
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The option that came the closest to gaining a majority was a proposal to keep Britain in a permanent customs union with the EU. Meanwhile, a proposal for a confirmatory referendum on any deal got the most votes but was defeated by 292 to 280.
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I know there's been criticism in some corners about the FDA's use of that pathway, but I think we've used that pathway in a thoughtful way, and the results have mostly borne out that the drugs do go on to demonstrate a confirmatory benefit.
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White House Press Secretary Stephanie Grisham said in a statement to Insider that "The White House is aware of public reports that a member of the Brazilian delegation's visit to Mar-a-Lago last weekend tested positive for COVID-19; confirmatory testing is pending,"
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The pound has reacted positively to the Conservatives' growing lead in the polls over the main opposition Labour party, and seemingly balked at the radical economic proposals the latter put forward in its manifesto last week alongside the promise of a confirmatory referendum on Brexit.
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The three latest patients - and a fourth new case believed to be travel-related in Washington state - were diagnosed based on results obtained in their respective states from CDC-supplied test kits and are considered "presumptive positive" cases pending CDC confirmatory testing, the U.S. agency said.
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"It's a fishing expedition to see if Bannon can provide them with confirmatory evidence regarding the firing of [former F.B.I. Director James] Comey and obstruction of justice, " said David Shapiro, a professor at John Jay College of Criminal Justice with FBI experience and a financial crimes specialization.
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Indicative votes will be held on proposals such as leaving with no-deal on April 12, seeking a "common market 2.0" deal that includes membership of the single market and a customs arrangement, and a plan for a confirmatory public vote to approve a Brexit deal.
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After looking at Stada's books, the private equity firms may eventually offer up to 60 euros per share, the sources said, adding that the confirmatory bids will likely be around the initial level of about 58 euros per share or 3.6 billion euros for all of Stada's equity.
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"The suspicious illness she had following delivery may have been a re-activation of Ebola, but we have no confirmatory tests," said Dr. Emily Kainne Dokubo, who led the Ebola response in Liberia for the U.S. Centers for Disease Control and Prevention, and the study&aposs lead author.
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May's de facto deputy David Lidington is due to send a letter to Labour shortly setting out May's Brexit offer, Steven Swinford said on Twitter, adding that while agreement had been reached on workers' rights, discussions were still ongoing on a customs union or equivalent and a confirmatory vote.
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There is an increasing expectation now that Britain could go in one of four directions — toward a no-deal departure from the bloc, holding a snap general election, Parliament agreeing to the U.K. remaining within a customs union with the EU and/or holding a confirmatory referendum on any eventual strategy.
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Bidders were requested to use the staple financing in the confirmatory stage in order to enable advising banks time to overcome tricky aspects of the financing regarding the vast amounts of unfunded facilities needed, so that they had access to banks that were not tied into exclusivity with particular bidders.
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Lilly also cited a number of other near-term challenges it faces, such as cheap generic competition for erectile dysfunction treatment Cialis, the recent global withdrawal of cancer drug Lartruvo after it failed to prove its benefit in a confirmatory clinical trial, and intense political pressure to lower insulin prices.
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"We're genuinely going in with an open mind, but if it comes out of that process without the idea of a confirmatory ballot, I think we would have a bit of difficulty with our parliamentary party," Watson said in an interview with BBC radio, adding that talks on customs arrangements could be easier.
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"It seems to me that if a patient has an interest in their pharmacogenetic profile that could impact medication decisions, they're probably better off just asking the physician about what testing can be done, since confirmatory testing is expected anyway even if you got 23andMe," says Boadie Dunlop, an Emory University psychiatrist who researchers biological markers that predict responses to drug treatments.
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For instance, 264 MPs voted for a customs union with the EU (to 272 against); 123 voted for the opposition Labour Party's proposal for a customs union plus close alignment with the single market (to 307 against) and 268 voted for a "confirmatory" referendum to approve a Brexit deal or to stay in the EU (with 295 against such a plan).
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Many Labour MPs have said that they would only be willing to back the deal if it was attached to a confirmatory public vote, and plan to table an amendment to Saturday's vote, insisting that a deal will only be approved if it wins majority support in a referendum, which Labour appears increasingly likely to whip their MPs in favour of.
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"We recommend that the success of accelerated approval pathway lies in the fact that confirmatory studies are duly conducted in time, and use clinical endpoints such as overall survival or quality of life to actually confirm benefit rather than test another surrogate measure," said Dr. Bishal Gyawali, a medical oncologist and assistant professor at Queen's University in Canada, who was first author of the study.
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If you look, there was some recent analysis put out on oncology drugs that were approved through accelerated approval, and the track record on drugs showing confirmatory benefits, they're showing the survival advantage that might have been approved on the basis of a surrogate market that was reasonably likely to predict clinical success as well as the products that haven't demonstrated that yet but are doing studies where they're on track to read out an answer is actually pretty good.
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