It has also been used by neurological clinics to treat patients who have asthenia -- an abnormal lack of energy.
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The condition was named after Jacob Mendes Da Costa, who investigated and described the disorder during the American Civil War. It is also variously known as cardiac neurosis, chronic asthenia, effort syndrome, functional cardiovascular disease, neurocirculatory asthenia, primary neurasthenia, subacute asthenia and irritable heart.
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Hypsioma asthenia is a species of beetle in the family Cerambycidae. It was described by Martins and Galileo in 1990. It is known from Brazil.BioLib.cz - Hypsioma asthenia.
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Asthenia is also a side effect of some medications and treatments, such as Ritonavir (a protease inhibitor used in HIV treatment), vaccines such as the HPV vaccine gardasil. Differentiating psychogenic (perceived) asthenia and true asthenia from myasthenia is often difficult, and in time apparent psychogenic asthenia accompanying many chronic disorders is seen to progress into a primary weakness. Myasthenia (my- from Greek μυο meaning "muscle" + -asthenia ἀσθένεια meaning "weakness"), or simply muscle weakness, is a lack of muscle strength. The causes are many and can be divided into conditions that have either true or perceived muscle weakness.
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There are two genetic traits linked to feline cutaneous asthenia. One comes from a dominant allele, while the other comes from a recessive. Both result in similar pathology. Cats with the autosomal dominant form of feline cutaneous asthenia package type I collagen poorly.
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Eugnosta asthenia is a species of moth of the family Tortricidae. It is found in Guatemala.
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In the homozygous state, it is apparently lethal. Feline cutaneous asthenia is similar to the Ehlers–Danlos syndrome of humans. Cats with cutaneous asthenia cannot be grasped by the scruff, as this may tear away. Cats may also have slipping joints, as in human Ehlers-Danlos syndrome.
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These symptoms could consist of asthenia, fever, anorexia, and weight loss. They mostly occur during a severe disease flare.
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The therapeutic effects of bromantane in asthenia are said to onset within 1- to 3-days. It has been proposed that the combination of psychostimulant and anxiolytic activity may give bromantane special efficacy in the treatment of asthenia. In a large-scale, multi-center clinical trial of 728 patients diagnosed with asthenia, bromantane was given for 28 days at a daily dose of 50 mg or 100 mg. The impressiveness were 76.0% on the CGI-S and 90.8% on the CGI-I, indicating broadly-applicable, high effectiveness.
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Tropical anhidrotic asthenia is a skin condition, a rare form of miliaria, with long-lasting poral occlusion, which produces anhidrosis and heat retention.
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Noteworthy side effects include dry mouth, headache, fatigue, dizziness, intermittent facial oedema, nausea, sleep disturbances (rarely sedation), asthenia, vasodilatation, and rarely, skin reactions.
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Asthenia (Greek: ἀσθένεια, lit lack of strength but also disease) is a medical term referring to a condition in which the body lacks or has lost strength either as a whole or in any of its parts. It denotes symptoms of physical weakness and loss of strength. General asthenia occurs in many chronic wasting diseases (such as tuberculosis and cancer), sleep disorders or chronic disorders of the heart, lungs or kidneys, and is probably most marked in diseases of the adrenal gland. Asthenia may be limited to certain organs or systems of organs, as in asthenopia, characterized by ready fatiguability.
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The GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) and the CAPE-V (Consensus Auditory Perceptual Evaluation—Voice) are two formal voice rating scales commonly used for this purpose.
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Feline cutaneous asthenia is a rare inheritable skin disease of cats characterised by abnormal elasticity, stretching, and improper healing of the skin. Pendulous wing-like folds of skin form on the cat's back, shoulders and haunches. Even stroking the cat can cause the skin to stretch and tear. A recessive autosomal (non-sex linked) form of feline cutaneous asthenia has been identified in Siamese cats and related breeds.
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Side effects experienced with this product will resemble those of other benzodiazepines. Drowsiness and asthenia are common side effects. There has been a report of hepatitis caused by clotiazepam.
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Diarrhea, hypertension, fatigue, decreased appetite, nausea, dysphonia, hand-foot syndrome, weight decreased, vomiting, asthenia, and constipation are the most common side effects occurring in more than 20% of patients.
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Paraz also reminisces over Couchoud's relationship with his future wife. Hinting that both spouses were not intransigent about the observance of faithfulness. Couchoud presented in Paris his doctorate thesis on primitive asthenia (1911).
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The most common adverse effect was headache (11%). The other minor adverse effects encountered in less than 5% of patients were asthenia, burning or stinging sensation, unpleasant taste, blurred vision, eye dryness and tearing.
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Some known side effects include headache (7% of occurrence), eye burning and/or stinging (5%), blurred vision, dry eyes, foreign body sensation, hyperemia, keratitis, eyelid edema, pruritus, asthenia, sore throat (pharyngitis), rhinitis, sinusitis, taste perversion, and vomiting.
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After working at the Karolinska Institute from 1945 to 1958, he became Professor of Neurology at the University of Uppsala where he worked until 1974. Ekbom's doctor thesis "Restless Legs Syndrome: A Clinical Study of a Hitherto Overlooked Disease in the Legs Characterized by Peculiar paresthesia ("anxietas Tibiarum"), Pain and Weakness and Occurring In Two Main Forms, asthenia Crurum Paraesthetica and asthenia Crurum Dolorosa" was published in 1944 or 1945. He introduced the term of the disease and described how to diagnosis it. For this he received the Swedish Lennmalms Prize in 1949.
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"Go" is the record's only straight punk rock song. "It's a personal song," said Hoppus. "It's not specifically about my mother… I feel weird talking about it." "Asthenia" uses real NASA transmissions from the Apollo 9 space flight.
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The most common side effects of darolutamide in clinical trials (≥2% incidence) in castrated men included fatigue and asthenia (16% vs. 11% for placebo), pain in extremities (6% vs. 3% for placebo), and rash (3% vs. 1% for placebo).
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Vitamin C is also given to cats in controlled doses, to assist with the translation of collagen. Given proper care, cats with feline cutaneous asthenia can live long lives, although the prognosis is not as positive if joint hypermobility is present.
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Nabilone can increase – rather than decrease – postoperative pain. In the treatment of fibromyalgia, adverse effects limit the useful dose. Adverse effects of nabilone include, but are not limited to: dizziness/vertigo, euphoria, drowsiness, dry mouth, ataxia, sleep disturbance, dysphoria, headache, nausea, disorientation, depersonalization, and asthenia.
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Muscle weakness can also be caused by low levels of potassium and other electrolytes within muscle cells. It can be temporary or long-lasting (from seconds or minutes to months or years). The term myasthenia is from my- from Greek μυο meaning "muscle" + -asthenia ἀσθένεια meaning "weakness".
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The psychostimulant effects of bromantane onset gradually within 1.5- to 2-hours and last for 8- to 12-hours. Bromantane is used clinically in doses of 50 mg to 100 mg per day in the treatment of asthenia. The main metabolite of bromantane is 6β-hydroxybromantane.
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In 1910 he was appointed assistant to the Professor of Natural Philosophy there, and in 1914, he was appointed Erasmus Smith's Professor of Mathematics.Death of a Scholar: Professor b. Kelener of Trinity The Irish Independent, August 20, 1917 He died on 18 August 1917, due to sarcomatosis asthenia.
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Symptoms include bloody stools, ecchymoses, blood leakage from venipuncture sites, mucosal & visceral hemorrhaging, and possibly hematemesis. # Late Organ Phase: Day 13 up to Day 21+. Symptoms bifurcate into two constellations for survivors & fatal cases. Survivors will enter a convalescence phase, experiencing myalgia, fibromyalgia, hepatitis, asthenia, ocular symptoms, & psychosis.
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Groves "Poco Bueno" Quarter Horse Journal April 1994 p. 18 Poco Bueno is the stallion that is linked to the genetic disease Hereditary Equine Regional Dermal Asthenia (HERDA) in stock horses. He was a solid brown horse with no white markings. When mature, he stood about high and weighed about 1200 pounds.
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Gastro-intestinal (GI) effects and asthenia are the most common adverse events.Highlights Of Prescribing Information Bortezomib is associated with peripheral neuropathy in 30% of patients resulting in pain. This can be worse in patients with pre-existing neuropathy. In addition, myelosuppression causing neutropenia and thrombocytopenia can also occur and be dose-limiting.
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The dermis is thinned because of this. In heterozygous cats, normal and abnormal fibrils often exist inside of the same collagen fiber. Homozygous cats are not likely to survive for very long. The autosomal recessive form of feline cutaneous asthenia results in a deficiency of procollagen peptidase or a structural abnormality at its cleavage site.
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"Yin deficiency, deficiency of essence, and external asthenia and sweating" (due to Wei Qi deficiency) are traditional contraindications. It has been noted to interfere with drugs for diabetes. It can cause allergic reactions in those who are allergic to ragweed, marigolds, daisies, or related herbs (Asteraceae). It should not be used by pregnant women or women who are breastfeeding.
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In June 1889 he married a widow, Margaret Kay, daughter of John Fawcus, a Justice of Peace who had four children from her earlier marriage. Mouat died on 12 January 1897 at his home in Durham Villas, Kensington from pneumonia and asthenia. He was cremated at Woking as wished by him. He left a widow and four stepchildren.
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As gefitinib is a selective chemotherapeutic agent, its tolerability profile is better than previous cytotoxic agents. Adverse drug reactions (ADRs) are acceptable for a potentially fatal disease. Acne-like rash is reported very commonly. Other common adverse effects (≥1% of patients) include: diarrhoea, nausea, vomiting, anorexia, stomatitis, dehydration, skin reactions, paronychia, asymptomatic elevations of liver enzymes, asthenia, conjunctivitis, blepharitis.
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Other reported side effects include somnolence, weight gain, clinical depression, weakness, increased libido, and hypersexuality. According to a 2005 review, piracetam has been observed to have the following side effects: hyperkinesia, weight gain, nervousness, somnolence, depression and asthenia. Piracetam reduces platelet aggregation as well as fibrinogen concentration, and thus is contraindicated to patients suffering from cerebral hemorrhage.
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England and Wales Civil Registration Indexes. London, England. No. 245, Seventh August 1921, 27 Hornsey Rise Gardens, Male, 72 years, Lithographer, Cause of death:(1)Hodgkiss disease [Hodgkins] (2)Asthenia, Informant: F A Brooks, Son present at death 27 Hornsey Rise Gardens Islington. and the business passed to two of his sons, Wilfred Vincent Brooks and Frederick Allan Brooks.
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Serious (grade 3 or 4) adverse events occur in ≤10% of patients and include hypertension, fatigue, asthenia, diarrhea, and chemotherapy-induced acral erythema. Lab abnormalities associated with sunitinib therapy include lipase, amylase, neutrophils, lymphocytes, and platelets. Hypothyroidism and reversible erythrocytosis have also been associated with sunitinib. Most adverse events can be managed through supportive care, dose interruption, or dose reduction.
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Complications include toxic megacolon, dehydration and sepsis. Such complications generally occur in young children (< 1 year of age) and immunocompromised people. A chronic course of the disease is possible; this disease process is likely to develop without a distinct acute phase. Chronic campylobacteriosis features a long period of sub-febrile temperature and asthenia; eye damage, arthritis, endocarditis may develop if infection is untreated.
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In "winged" cats with cutaneous asthenia, the pseudo-wings only occur on the shoulders, haunches, or back, and the cats can often actively move these growths, suggesting the presence of neuromuscular tissue within them, which is not present within clumps of matted fur alone. The third explanation is a form of conjoining or extra supernumerary limbs. These non-functional or poorly functional growths would be fur-covered and might resemble wings, as in one winged-cat case recently documented by Karl Shuker , in which the "wings" were shown to be supernumerary limbs. There are more than 138 reported sightings of animals claimed to be winged cats, though most of these are clearly nothing more than individuals with clumps of matted fur, some cases of cutaneous asthenia or supernumerary limbs, and others taxidermy frauds (freakshow "grifts"), or just sensationalist tabloid journalism.
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Chemical structure of riluzole, a medication that prolongs survival by 2–3 months Riluzole has been found to modestly prolong survival by about 2–3 months. It may have a greater survival benefit for those with bulbar-onset ALS. It may work by decreasing release of the excitatory neurotransmitter glutamate from pre-synaptic neurons. The most common side effects are nausea and a lack of energy (asthenia).
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In 1856 he was knighted by Queen Victoria for his work on the telegraph in India. He was appointed Director-General of Telegraphs at this time. During the following years O'Shaughnessy wrote on telegraphy- related subjects, including a book of Private Codes for encrypted telegraphy. In 1860, O'Shaughnessy returned to Europe for sick leave where he remained in obscurity until his death from senile asthenia at Southsea on 8 January 1889.
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Arytenoid adduction with or without medialization thyroplasty significantly improves quality of life for patients with vocal cord paralysis. Subjective outcome measures of voice quality include the Grade, Roughness, Breathiness, Asthenia, Strain (GBRAS) voice scale, Voice Handicap Index, and closure of the glottic gap. Objective outcome measures include mean and maximum phonation time, phonotory airflow, and signal-to-noise ratio. Arytenoid adduction produces improvements in all of these parameters.
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The most common adverse effects observed with lopinavir/ritonavir are diarrhea and nausea. In key clinical trials, moderate or severe diarrhea occurred in up to 27% of patients, and moderate/severe nausea in up to 16%. Other common adverse effects include abdominal pain, asthenia, headache, vomiting and, particularly in children, rash. Raised liver enzymes and hyperlipidemia (both hypertriglyceridemia and hypercholesterolemia) are also commonly observed during lopinavir/ritonavir treatment.
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The most common adverse effects affecting 5 to 15% of the patients include allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, and stinging. 1 to 5% of the patients in clinical trials experienced asthenia, blepharitis, corneal erosion, depression, epiphora, eye discharge, eye dryness, eye irritation, eye pain, eyelid edema, eyelid erythema, eyelid pruritus, foreign body sensation, headache, hypertension, oral dryness, somnolence, superficial punctate keratitis, and visual disturbance.
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As Călinescu suggests, I. M. Rașcu was a "constant" Symbolist, oriented toward a trademark "provincial", "Sunday" poetry, which mirrored his "melancholy seclusion" and "sacred bucolic joys". Cultural historian and critic Eugen Lovinescu summarizes Rașcu's poetry as "asthenia", "projecting life beyond reality, into the realm of dreams, [...] the life of a bloodless ghost".Lovinescu, p. 117 Critic Tudor Vianu reads Rașcu as mainly a Moldavian Symbolist, in line with Bacovia, Ștefan Petică, and Demostene Botez.
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The most common side effect of tiagabine is dizziness. Other side effects that have been observed with a rate of statistical significance relative to placebo include asthenia, somnolence, nervousness, memory impairment, tremor, headache, diarrhea, and depression. Adverse effects such as confusion, aphasia (difficulty speaking clearly)/stuttering, and paresthesia (a tingling sensation in the body's extremities, particularly the hands and fingers) may occur at higher dosages of the drug (e.g., over 8 mg/day).
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Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer. It is indicated for use in conjunction with castration in the treatment of metastatic castration-resistant prostate cancer (mCRPC), nonmetastatic castration-resistant prostate cancer, and metastatic castration-sensitive prostate cancer (mCSPC). It is taken by mouth. Side effects of enzalutamide when added to castration include asthenia, back pain, diarrhea, arthralgia, and hot flashes.
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Onset of symptoms usually occur in early adulthood and is characterized by intention tremor, progressive ataxia, convulsions, and myoclonic epileptic jerks. Tremors usually affect one extremity, primarily the upper limb, and eventually involve the entire voluntary motor system. Overall, the lower extremity is usually disturbed less often than the upper extremity. Additional features of the syndrome include: an unsteady gait, seizures, muscular hypotonia, reduced muscular coordination, asthenia, adiadochokinesia and errors with estimating range, direction, and force of voluntary movements.
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Darolutamide, sold under the brand name Nubeqa, is an antiandrogen medication which is used in the treatment of non-metastatic castration-resistant prostate cancer in men. It is specifically approved to treat non-metastatic castration- resistant prostate cancer (nmCRPC) in conjunction with surgical or medical castration. The medication is taken by mouth twice per day with food. Side effects of darolutamide added to castration may include fatigue, asthenia, pain in the arms and legs, and rash.
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The therapeutic benefit against asthenia was notably observed to still be present one-month after discontinuation of the drug, indicating long-lasting positive effects of bromantane. Quality of life was significantly increased by bromantane, and this increase remained at one-month after withdrawal of bromantane. 3% of patients experienced side effects; none of the adverse effects were serious; and 0.8% of patients discontinued treatment due to side effects. Bromantane was also noted to normalize the sleep-wake cycle.
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Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia). It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease, dizziness, for the prevention of motion sickness, and for the prevention of anxiety before or after surgical procedures or painful diagnostic tests.
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During the initial phase of the therapy, before GnRH receptors have been significantly downregulated, testosterone levels are increased. This can lead to transient tumor activation with bone pain (in patients with cancer metastases) and urinary retention. Side effects that occur later during the treatment are mainly due to low sex hormone levels and include reduced libido, erectile dysfunction, hot flashes, vaginal dryness, vaginal atrophy, menorrhagia, osteoporosis, depression, asthenia, emotional lability, headache, dizziness, and application site reactions.
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Hereditary motor and sensory neuropathy with proximal dominance (HMSN-P) is an autosomal dominant neurodegenerative disorder that is defined by extensive involuntary and spontaneous muscle contractions, asthenia, and atrophy with distal sensory involvement following. The disease starts presenting typically in the 40s and is succeeded by a slow and continuous onslaught. Muscle spasms and muscle contractions large in number are noted, especially in the earliest stages. The presentation of HMSN-P is quite similar to amyotrophic lateral sclerosis and has common neuropathological findings.
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Serious adverse effects connected to bevacizumab are infrequent but among those listed are gastrointestinal perforation, arterial thromboembolic events, hypertensive crisis, neutropenia, complications with wound healing, haemorrhage, nephrotic syndrome, heart failure and reversible posterior leukoencephalopathy syndrome. Sunitinib is a small molecule inhibitor which inhibits phosphorylation of VEGF receptor among other receptors. Sunitinib is mostly well tolerated. Common adverse effects which have an incidence rate of 20% are fatigue, asthenia, diarrhea, nausea, dyspepsia, abdominal pain, constipation, hypertension, skin discoloration, altered taste, stomatitis and mild bleeding.
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Peginterferon beta-1a', sold under the brand name Plegridy, is medication used to treat multiple sclerosis. The most common side effects include headache, muscle pain, joint pain, influenza (flu)-like symptoms, pyrexia (fever), chills, asthenia (weakness), and erythema (reddening of the skin), pain or pruritus (itching) at the injection site. Peginterferon beta-1a was approved for medical use in the United States and in the European Union in 2014. Text was copied from this source which is © European Medicines Agency.
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Common side effects of anastrozole (≥10% incidence) include hot flashes, asthenia, arthritis, pain, arthralgia, hypertension, depression, nausea and vomiting, rash, osteoporosis, bone fractures, back pain, insomnia, headache, bone pain, peripheral edema, coughing, dyspnea, pharyngitis, and lymphedema. Serious but rare adverse effects (<0.1% incidence) include skin reactions such as lesions, ulcers, or blisters; allergic reactions with swelling of the face, lips, tongue, and/or throat that may cause difficulty swallowing or breathing; and abnormal liver function tests as well as hepatitis.
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Retrospective analysis of the data from the Soviet Space Biology and Medicine III Mir Space Station study (see ) has shown that the findings did not support the presence of the asthenization syndrome when crew member on-orbit scores were compared with those from a prototype of asthenization developed by Russian space experts.Kanas, N., Salnitskiy, V., Gushin, V., Weiss, D.S., Grund, E.M., Flynn, C., Kozerenko, O., Sled, A., Marmar, C.R. (2001). Asthenia – Does it exist in space? Psychosom. Med., 63, 874–880.
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Pertuzumab/trastuzumab/hyaluronidase, sold under the brand name Phesgo, is a fixed-dose combination medication to treat adults with HER2-positive breast cancer that has spread to other parts of the body, and for treatment of adults with early HER2-positive breast cancer. It contains pertuzumab, trastuzumab, and hyaluronidase–zzxf. It is injected under the skin via subcutaneous injection in the thigh. The most common side effects include alopecia (hair loss), nausea, diarrhea, anemia (reduced number of red blood cells) and asthenia (lack of energy).
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The specific cause of death was listed as asthenia (a weakening of the body), a cover-all medical term used by doctors of that time. However, he no doubt suffered from a wide variety of serious physical complaints. In addition to the mastoiditis, he was afflicted with cancer, advanced cirrhosis of the liver, alcohol-related brain damage, and according to some sources, paresis. Some sources erroneously report that he died in an insane asylum; he was in Lakeland Asylum a short time before he died.
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Vinorelbine has a number of side- effects that can limit its use: Chemotherapy-induced peripheral neuropathy (a progressive, enduring and often irreversible tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs), lowered resistance to infection, bruising or bleeding, anaemia, constipation, vomitings, diarrhea, nausea, tiredness and a general feeling of weakness (asthenia), inflammation of the vein into which it was injected (phlebitis). Seldom severe hyponatremia is seen. Less common effects are hair loss and allergic reaction.
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Fentanyl's most common side effects, which affect more than 10% of people, include diarrhea, nausea, constipation, dry mouth, somnolence, confusion, asthenia (weakness), sweating. Less frequently, in 3-10% of people, fentanyl can cause abdominal pain, headache, fatigue, anorexia and weight loss, dizziness, nervousness, hallucinations, anxiety, depression, flu-like symptoms, dyspepsia (indigestion), shortness of breath, hypoventilation, apnoea, and urinary retention. Fentanyl use has also been associated with aphasia. Despite being a more potent analgesic, fentanyl tends to induce less nausea, as well as less histamine-mediated itching, than morphine.
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Sunitinib adverse events are considered somewhat manageable and the incidence of serious adverse events low. The most common adverse events associated with sunitinib therapy are fatigue, diarrhea, nausea, anorexia, hypertension, a yellow skin discoloration, hand-foot skin reaction, and stomatitis. In the placebo-controlled Phase III GIST study, adverse events which occurred more often with sunitinib than placebo included diarrhea, anorexia, skin discoloration, mucositis/stomatitis, asthenia, altered taste, and constipation. Dose reductions were required in 50% of the patients studied in RCC in order to manage the significant toxicities of this agent.
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Harm avoidance has also been found to have moderate inverse relationships with conscientiousness and openness to experience in the five factor model. The HA of TPQ and TCI-R has four subscales: # Anticipatory worry (HA1) # Fear of uncertainty (HA2) # Shyness/Shyness with strangers (HA3) # Fatigability/Fatigability and asthenia (weakness) (HA4) It has been suggested that HA is related to high serotonergic activity, and much research has gone into investigating the link between HA and components of the serotonin system, e.g. genetic variation in 5-HTTLPR in the serotonin transporter gene.
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The occurrence of mats in longhaired cats is easily recognisable by experienced cat owners and breeders, but not recognisable to novices. Matted fur is not considered notable and rarely reported, except by those unfamiliar with the condition. Although mats can occur all over a longhaired cat's body, to novice eyes, they are most noticeable on the flanks when the cat is in motion. The second explanation of reports of winged cats is a skin condition called feline cutaneous asthenia, which is related to Ehlers–Danlos syndrome (elastic skin) in humans.
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Other possible side effects that can occur are areflexia, asthenia, ataxia, blurred vision, disorientation, dizziness, drowsiness, dysarthria, dysmetria, fainting, hyporeflexia, slurred speech, somnolence, staggering, coma, apnea, shallow breathing, sleepiness, premature ventricular contraction, tachycardia, miosis, and dry mouth. Rarely, hypotonia, dry mouth, urinary incontinence and nonspecific electrocardiographic ST segment changes occur. It has been reported that the duration of symptoms after human overdose is 8 to 72 hours. Further research is necessary to categorize the side effects that occur when xylazine is used in conjunction with heroin and cocaine.
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The Zomig ZMT dissolvable pill contains aspartame, and should be avoided by anyone sensitive to that ingredient and by those suffering from phenylketonuria. Rarely, serious cardiac events, including myocardial infarction (heart attack), have been associated with zolmitriptan. Reported minor adverse reactions include: hypesthesia, paresthesia (all types), warm and cold sensations, chest pain, throat and jaw tightness, dry mouth, dyspepsia, dysphagia, nausea, somnolence, vertigo, asthenia, myalgia, myasthenia and sweating. Following administration of cimetidine, the half-life and AUC of zolmitriptan and its active metabolites were approximately doubled (see CLINICAL PHARMACOLOGY in product pamphlet).
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During the La Reunion outbreak in 2006, more than 50% of subjects over the age of 45 reported long-term musculoskeletal pain with up to 60% of people reporting prolonged painful joints three years following initial infection. A study of imported cases in France reported that 59% of people still suffered from arthralgia two years after acute infection. Following a local epidemic of chikungunya in Italy, 66% of people reported muscle pains, joint pains, or asthenia at one year after acute infection. Currently, the cause of these chronic symptoms is not fully known.
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Subjective measures include scales such as the Grade, Roughness, Breathiness, Asthenia, Strain Scale (GRBAS); the Reflux Symptom Index; the Voice Handicap Index (VHI); and a voice symptom scale. Objective measures often rely on acoustic parameters such as jitter, shimmer, signal-to-noise ratio, and fundamental frequency, among others. Aerodynamic measures such as vital capacity and maximum phonation time (MPT) have also been used as an objective measure. However, there is not yet a consensus on how best to use the measures or which measures are best to assess treatment outcomes for LPR.
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Avapritinib, sold under the brand name Ayvakit among others, is a medication used for the treatment of tumors due to one specific rare mutation: It is specifically intended for adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbor a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation. Common side effects are edema (swelling), nausea, fatigue/asthenia (abnormal physical weakness or lack of energy), cognitive impairment, vomiting, decreased appetite, diarrhea, hair color changes, increased lacrimation (secretion of tears), abdominal pain, constipation, rash and dizziness. Avapritinib is a kinase inhibitor.
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Expression of toxicity following exposure may involve a latent period of several hours, followed by signs such as nausea, abdominal pain, weakness, confusion, pulmonary edema, and seizures. Individuals who survive the acute phase often require a prolonged convalescence. Persistent neurological deficits such as asthenia, cognitive impairment, optical atrophy, and paresthesia are frequently present after moderate to severe poisoning. Blood or urine concentrations of inorganic bromide, a bromomethane metabolite, are useful to confirm a diagnosis of poisoning in hospitalized patients or to assist in the forensic investigation of a case of fatal overdosage.
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Mesocarb (brand names Sidnocarb, Sydnocarb) is a drug that is currently being developed for Parkinson's disease. The drug was originally developed in the USSR in the 1970s GB Patent 1262830 - NOVEL SYDNONIMINE DERIVATIVE for a variety of indications including asthenia, apathy, adynamia and some clinical aspects of depression and schizophrenia. Mesocarb was used for counteracting the sedative effects of benzodiazepine drugs, increasing workload capacity and cardiovascular function, treatment of ADHD and hyperactivity in children, as a nootropic, and as a drug to enhance resistance to extremely cold temperatures. It is also listed as having antidepressant and anticonvulsant properties.
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Although feline cutaneous asthenia is not curable, there are treatment and management options for the disease. Affected animals must be kept away from others, and sharp corners on tables and other furniture must be padded. Cats should be declawed, so that they cannot injure themselves while scratching, and it is often advised that males be neutered, both because of the heritability of the disease and because there is a chance of injury during mating. If something causes the skin to tear, it should be sutured if possible, and the wound should be treated with antibiotics as needed.
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Side effects observed in fluoxetine-treated persons in clinical trials with an incidence >5% and at least twice as common in fluoxetine-treated persons compared to those who received a placebo pill include abnormal dreams, abnormal ejaculation, anorexia, anxiety, asthenia, diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, decreased libido, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilation, and yawning. Fluoxetine is considered the most stimulating of the SSRIs (that is, it is most prone to causing insomnia and agitation). It also appears to be the most prone of the SSRIs for producing dermatologic reactions (e.g. urticaria (hives), rash, itchiness, etc.).
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However, Seymour would not live to see British Columbia unified with Canada. On 10 June 1869, Seymour died from typhoid asthenia on board HMS Sparrowhawk near the north coast of British Columbia. Seymour's body was transported to Victoria, British Columbia's chosen capital. After Seymour's death the colonial office was quick to find a replacement for him News of his death reached the Government House by the early hours of the morning on June 14, before noon that same day the Colonial Secretary, Lieutenant Philip James Hankin, R.N. had become the temporary administrator of the United Colonies.
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The medical term neurasthenia is translated as Chinese shenjing shuairuo () or Japanese shinkei-suijaku (神経衰弱), both of which also translate the common term nervous breakdown. This loanword combines shenjing (神經) or shinkei (神経) "nerve(s); nervous" and shuairuo or suijaku (衰弱) "weakness; feebleness; debility; asthenia". Despite being omitted by the American Psychiatric Association's DSM in 1980, neurasthenia is listed in an appendix as the culture-bound syndrome shenjing shuairuo as well as appearing in the ICD-10. The condition is thought to persist in Asia as a culturally acceptable diagnosis that avoids the social stigma of a diagnosis of mental disorder.
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Kraatz - Menges / edited by Rudolf Vierhaus Deutsche Biographische EnzyklopaedieErich Leschke at Who Named It His name is associated with Leschke's syndrome, a condition characterized by a combination of asthenia, multiple brown pigment spots on the skin and hyperglycemia. He described the syndrome in a 1922 paper titled Über Pigmentierung bei Funktionsstörungen der Nebenniere und des sympathischen Nervensystems bei der Recklinghausenschen Krankheit.Stedman's Medical Eponyms by Thomas Lathrop StedmanLeschke's syndrome Who Named It He was the author of numerous papers regarding cardiac, pulmonary and metabolic diseases. His book Die wichtigsten vergiftungen, Fortschritte in deren Erkennung und Behandlung was translated into English and published as Clinical toxicology; modern methods in the diagnosis and treatment of poisoning (1934).
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In 1870 Arthur Bowen Myers of the Coldstream Guards also regarded the accoutrements as the cause of the trouble, which he called neurocirculatory asthenia and cardiovascular neurosis. J. M. Da Costa’s study of 300 soldiers reported similar findings in 1871 and added that the condition often developed and persisted after a bout of fever or diarrhoea. He also noted that the pulse was always greatly and rapidly influenced by position, such as stooping or reclining. A typical case involved a man who was on active duty for several months or more and contracted an annoying bout of diarrhoea or fever, and then, after a short stay in hospital, returned to active service.
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Since the 1930s, ibogaine was sold in France in 8 mg tablets in the form of Lambarène, an extract of the Tabernanthe manii plant. 8 mg of ibogaine could be considered a microdose since doses in ibogatherapy and -rituals vary in the range of 10 mg/kg to 30 mg/kg adding usually up to 1000 mg. Lambarène was advertised as a mental and physical stimulant and was "...indicated in cases of depression, asthenia, in convalescence, infectious disease, [and] greater than normal physical or mental efforts by healthy individuals". The drug enjoyed some popularity among post World War II athletes, but was eventually removed from the market, when the sale of ibogaine-containing products was prohibited in 1966.
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The most common serious adverse reactions to avelumab are immune-mediated adverse reactions (pneumonitis, hepatitis, colitis, adrenal insufficiency, hypo- and hyperthyroidism, diabetes mellitus, and nephritis) and life-threatening infusion reactions. Among the 88 patients enrolled in the JAVELIN Merkel 200 trial, the most common adverse reactions were fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reaction, rash, decreased appetite, and peripheral edema. Serious adverse reactions that occurred in more than one patient in the trial were acute kidney injury, anemia, abdominal pain, ileus, asthenia, and cellulitis. The most common serious risks are immune-mediated, where the body’s immune system attacks healthy cells or organs, such as the lungs (pneumonitis), liver (hepatitis), colon (colitis), hormone-producing glands (endocrinopathies) and kidneys (nephritis).
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Alimemazine (INN), also known as trimeprazine, (brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine). It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic. In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses.
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Book 3 also contains an extensive chapter about neuroscience, which "begins by explaining the structure and function of the nervous system, …parts of the brain, the spinal cord, the ventricles, meninges, nerves and roots, … [and] neurological and neuropsychological disorders, including signs and symptoms and treatment strategies". Furthermore, several specific neurological conditions are described, including: epilepsy, apoplexy and stroke, paralysis, vertigo, spasm, wry mouth, tremor, meningitis, amnesia and dementia, head injuries and traumas, hysteria and conversion disorder, fainting and stupor, nervous tic, sexual disorders, love sickness, delusion and hallucination, insomnia, sopor, nightmare, mania and psychosis, melancholia, paranoia, asthenia, hydrocephalus, and sciatica. Book 3 of the Canon of Medicine also describes fifteen kinds of headaches, as well as descriptions of treatments for each of these conditions that are divided into three steps: 1\. Change of lifestyle 2\.
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A DNA test is available for LWS so that horses who are carriers of this gene are not bred to one another. Horses can carry the LWS gene and not visibly exhibit overo coloring; cases have appeared in the offspring of both tobiano and solid-colored parents, though all cases to date are horses that had overo ancestors. LWS is also not unique to Paint Horses; it can occur in any equine breed where the frame overo coat pattern is found. Due to the heavy influx of American Quarter Horse breeding, some Paints may also carry genetic disorders such as hyperkalemic periodic paralysis (HYPP), hereditary equine regional dermal asthenia (HERDA), equine polysaccharide storage myopathy (called PSSM - polysaccharide storage myopathy - in Paints, Quarter Horses and Appaloosas), malignant hyperthermia (MH) and glycogen branching enzyme deficiency (GBED).
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The phrase pneuma astheneias, "spirit of infirmity" or "spirit of weakness," is unique in the New Testament to the Gospel of Luke, as is the story in which it appears: Luke is the gospel writer who was a physician, and while his profession may have motivated his interest, nothing suggests a medical diagnosis. Asthenia throughout the New Testament means "weakness" or "powerlessness" of any kind, including sickness. Some have seen the affliction as ankylosing spondylitis, but an alternative interpretation is that hard labor over the years had bent the woman's back. The incident has been examined at length from the perspective of feminist theology by Francis Taylor Gench, who views it as both healing and liberating; Jesus goes on to say that the woman has been freed from a kind of bondage to Satan.
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There is some uncertainty about which painter actually encountered Hilder's work first and the date at which the encounters occurred. G. Hla Maung, Nyan Shein, and Amar all state or suggest that Ba Zaw first discovered Hilder's work, while Ko Ko Naing is the single detractor, claiming that Saya Saung became a student of Ba Zaw after Saya Saung started using Hilder's paintings for learning exercises. In Burmese Painting: A Linear and Lateral History, Ranard speculates that Hilder's landscapes of Australia, done in subdued color in the British style, may have appealed to Ba Zaw because these works resembled the brownish orange landscapes of Burma. He also draws parallels between the tragic history of both artists, their high-strung temperaments, their lives marked by “asthenia”, and their “aesthetic austerity” (which may have drawn them to the purity of watercolor transparency, unmixed with white).
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Velaglucerase alfa, sold under the brand name Vpriv and manufactured by Shire plc, is a hydrolytic lysosomal glucocerebroside-specific enzyme, which is a recombinant form of glucocerebrosidase indicated as a long-term enzyme replacement therapy for those suffering of Gaucher disease Type 1. It has an identical amino acid sequence to the naturally occurring enzyme.University of Birmingham: Velaglucerase alfa for type 1 Gaucher's disease It was approved for use by the U.S. Food and Drug Administration (FDA) on February 26, 2010.Medical News Today: Shire Announces FDA Approval Of VPRIV (velaglucerase Alfa For Injection) For The Treatment Of Type 1 Gaucher Disease, 27 February 2010 The most common side effects include abdominal (belly) pain, headache, dizziness, bone pain, arthralgia (joint pain), back pain, infusion-related reactions, asthenia (weakness) or fatigue (tiredness), and pyrexia (fever) or increased body temperature.
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Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction. Serious side effects may include suicide in those under the age of 25, serotonin syndrome, and mania. While rate of side effects appear similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndromes may occur more often. Use in pregnancy is not recommended while use during breastfeeding is relatively safe. Paroxetine shares many of the common adverse effects of SSRIs, including (with the corresponding rates seen in people treated with placebo in parentheses): nausea 26% (9%), diarrhea 12% (8%), constipation 14% (9%), dry mouth 18% (12%), somnolence 23% (9%), insomnia 13% (6%), headache 18% (17%), hypomania 1% (0.3%), blurred vision 4%(1%), loss of appetite 6% (2%), nervousness 5% (3%), paraesthesia 4% (2%), dizziness 13% (6%), asthenia (weakness; 15% (6%)), tremor 8% (2%), sweating 11% (2%), and sexual dysfunction (≥10% incidence).
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