As with city neighborhoods, TADs come in a range of sizes, from tiny walkable zones a few dozen DNA subunits long to TADs that sprawl over tens of thousands of bases and you're better off taking the subway.
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We reaffirm and develop new proofs of our TADS — teenagers are a different species — theory.
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Fijne dag #bezigbijtje #essiehealthylife Mate, your vegan breakfast is sporting a serious set of tads. Nadgers. Swinger.
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The best evidence for the importance of TADs is to see what happens when they break down.
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The mutations affect a newly discovered design feature of the DNA molecule called topologically associating domains, or TADs.
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The two primary development environments, TADS ("Text Adventure Development System") and Inform, formed the core of an interactive fiction renaissance.
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By expanding the scope of player inputs, TADS and Inform expanded the very definition of what an interactive game could be.
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The parsers built into TADS and Inform can understand multi-word phrases with words of any length, opening up a number of conversational possibilities.
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Through chromosome conformation studies and related research, scientists have discovered the genome is organized into about 2,000 jurisdictions, and they are beginning to understand how these TADs operate.
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Where an Adventure player might be limited to fight a troll, a more peace-loving player of TADS or Inform could ask a troll about his mother, give fresh-baked bread to a troll or even just say hello to a troll.
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Because TADs can be quite large, the way the Upper West Side of Manhattan comprises an area of about 250 square blocks, a genetic enhancer located at the equivalent of, say, Lincoln Center on West 65th Street, can amplify the activity of a gene positioned at the Cathedral of St. John the Divine, 45 blocks north.
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By studying TADs, researchers hope to better fathom the deep structure of the human genome, in real time and three dimensions, and to determine how a quivering, mucilaginous string of some three-billion chemical subunits that would measure more than six-feet long if stretched out nonetheless can be coiled and compressed down to four-10,000ths of an inch, the width of a cell nucleus — and still keep its operational wits about it.
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Replication timing domains have been shown to be associated with TADs as their boundary is co localized with the boundaries of TADs that are located at either sides of compartments. Insulated neighborhoods, DNA loops formed by CTCF/cohesin-bound regions, are proposed to functionally underlie TADs.
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Topologically associating domains (TADs) are megabase-size regions of relatively high DNA interaction frequencies. Mechanistic studies indicate TADs are single insulated neighborhoods or collections of insulated neighborhoods.
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TADS / PNVS on a Boeing AH-64 Apache helicopter The Target Acquisition and Designation Sights, Pilot Night Vision System (TADS/PNVS) is the combined sensor and targeting unit fitted to the Boeing AH-64 Apache helicopter. Both systems are independent, but housed together. Lockheed Martin signed the original TADS/PNVS production contract on 30 April 1982, and the first TADS/PNVS system was fielded in 1983."Lockheed Martin Awarded $385.6 Million Arrowhead Production Contract" .
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This technology has further aided the genetic and epigenetic study of chromosomes both in model organisms and in humans. These methods have revealed large-scale organization of the genome into topologically associating domains (TADs), which correlate with epigenetic markers. Some TADs are transcriptionally active, while others are repressed. Many TADs have been found in D. melanogaster, mouse and human.
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Images from the leaked thumb TADS contains stabilized electro- optical sensors, a laser rangefinder and laser target designator. The TADS assembly can rotate +/− 120 degrees in azimuth, +30/−80 degrees in elevation and can move independently of the PNVS. The movements of TADS can be 'slaved' to the head movements of the helicopter crew to point where they are looking. This allows images from TADS to be projected onto the crew helmet-mounted optical sights, overlaid upon their view of the cockpit and battle space.
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Kaged is a work of interactive fiction written by Ian Finley, set in a dystopian alternative world influenced by Nineteen Eighty-Four and Kafka. It won the 2000 annual Interactive Fiction Competition, and, at least through 2008, was the only game written in TADS to win the competition since the Inform and TADS categories were combined in 1996. The game is a multimedia release with text and graphics, written in an HTML-TADS format.
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Eric Eve is an author, interactive fiction writer, and New Testament scholar at Harris Manchester College in Oxford.SPAG interview He is known in the interactive fiction community for his writings on TADS 3, including three tutorial/reference books (Getting Started in TADS 3, Learning TADS 3, and the TADS 3 Tour Guide) and several articles for Brass Lantern, a site that hosts articles about and reviews of interactive fiction. He has also authored eleven interactive fiction games, several of which have won awards at various competitions. In the academic field, Eric Eve has also written two books relating to the New Testament, The Healer from Nazareth: Jesus' Miracles in Historical Context and The Jewish Context of Jesus' Miracles.
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As of 2005 a program was under way to upgrade the U.S. Apache fleet to the Modernized-TADS/PNVS (M-TADS/PNVS) standard, also known as Arrowhead.$262.4M in Arrowheads for Apaches Defense Industry Daily, 2 May 2005 This upgrade is claimed to give a 150% performance and reliability improvement, while reducing costs through lower maintenance requirements.
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The old town hall building was turned into a micropub, the Cuckoo, which opened in 2014. St George's Church Toddington has one theatre - Tads Theatre, on Conger Lane. It is owned and run by the charity group Tads Theatre, formerly known as the Toddington Amateur Dramatics Society. The group mounts 4-6 in-house productions each year, including an annual family pantomime.
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Parsers are used in early interactive fiction games like the Zork series, and more recently in games created by systems like Inform and TADS.
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Related studies demonstrate that metazoan genomes are partitioned in structural and functional units around a megabase long called Topological association domains (TADs) containing dozens of genes regulated by hundreds of enhancers distributed within large genomic regions containing only non-coding sequences. The function of TADs is to regroup enhancers and promoters interacting together within a single large functional domain instead of having them spread in different TADs. However, studies of mouse development point out that two adjacent TADs may regulate the same gene cluster. The most relevant study on limb evolution shows that the TAD at the 5’ of the HoxD gene cluster in tetrapod genomes drives its expression in the distal limb bud embryos, giving rise to the hand, while the one located at 3’ side does it in the proximal limb bud, giving rise to the arm.
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These insulators are DNA-binding proteins like CTCF and TFIIIC that help recruiting structural partners such as cohesins and condensins. The localization and binding of architectural proteins to their corresponding binding sites is regulated by post-translational modifications. DNA binding motifs recognized by architectural proteins are either of high occupancy and at around a megabase of each other or of low occupancy and inside TADs. High occupancy sites are usually conserved and static while intra-TADs sites are dynamic according to the state of the cell therefore TADs themselves are compartmentalized in subdomains that can be called subTADs from few kb up to a TAD long (19).
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TADs have been reported to be relatively constant between different cell types (in stem cells and blood cells, for example), and even between species in specific cases.
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In addition, the supercoiling- driven loop extrusion mechanism is consistent with earlier explanations proposing why TADs flanked by convergent CTCF binding sites form more stable chromatin loops than TADs flanked by divergent CTCF binding sites. In this model, the supercoiling also stimulates enhancer promoter contacts and it is proposed that transcription of eRNA sends the first wave of supercoiling that can activate mRNA transcription in a given TAD. 50px Material was copied from this source, which is available under a Creative Commons Attribution 4.0 International License. Computational models also showed that cohesin rings act like a very efficient molecular comb, pushing knots and entanglements such as in catenanes towards border of TADs where these are removed by the action of topoisomerases.
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Treatment for Adolescents With Depression Study (TADS) Team. Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial. JAMA. 2004;292(7):807–820. doi:10.1001/jama.292.7.807 In addition, CBT is recommended as the first line of treatment for the majority of psychological disorders in children and adolescents, including aggression and conduct disorder. Researchers have found that other bona fide therapeutic interventions were equally effective for treating certain conditions in adults.
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TADS contains a thermographic camera and a monochrome daylight television camera. With the improvements planned with M-TADS in the block III level AH-64D, the monochrome TV-camera is planned to be replaced with a full color camera. It also used to contain direct-view optics (DVO) which the copilot/gunner (CPG) could see through the Optical Relay Tube (ORT). But in recently fielded models of the AH-64D the ORT along with the DVO has been removed as it was rarely used.
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Changing the transcription pattern of genes changes the location of cohesin indicating that localization of cohesin may depend on transcription. # In another model, chromatin loop extrusion is pushed by transcription generated supercoiling ensuring also that cohesin relocalizes quickly and loops grow with reasonable speed and in a good direction. In addition, the supercoiling-driven loop extrusion mechanism is consistent with earlier explanations proposing why topologically associating domains (TADs) flanked by convergent CTCF binding sites form more stable chromatin loops than TADs flanked by divergent CTCF binding sites.
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Computer simulations have shown that transcription-induced supercoiling of chromatin fibres can explain how TADs are formed and how they can assure very efficient interactions between enhancers and their cognate promoters located in the same TAD.
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The Frenetic Five is a series of three text adventures about a band of superheroes, all made with TADS version 2 and distributed as freeware. The series was created by Neil deMause for the Interactive Fiction Competition.
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Like many other transcription factors, STATs are capable of recruiting co-activators such as CBP and p300, and these co-activators increase the rate of transcription of target genes. The coactivators are able to do this by making genes on DNA more accessible to STATs and by recruiting proteins needed for transcription of genes. The interaction between STATs and coactivators occurs through the transactivation domains (TADs) of STATs. The TADs on STATs can also interact with histone acetyltransferases (HATs); these HATs add acetyl groups to lysine residues on proteins associated with DNA called histones.
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The Apache Arrowhead (also Modernized Target Acquisition and Designation Sight/Pilot Night Vision Sensor or M-TADS/PNVS), is an integrated targeting and night vision system developed by Lockheed Martin for the Boeing AH-64 Apache attack helicopter. It uses second-generation long-wave Forward looking infrared (FLIR) sensors with three fields of view, a charge-coupled device TV camera, dual field of view pilotage FLIR, electronic zoom, target tracker and auto-boresight. It is the second generation of the Target Acquisition and Designation Sights, Pilot Night Vision System (TADS/PNVS) first fielded on Apaches in 1983.
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Still, it is not known whether TADs are an adaptive strategy to enhance regulatory interactions or an effect of the constrains on these same interactions. TAD boundaries are often composed by housekeeping genes, tRNAs, other highly expressed sequences and Short Interspersed Elements (SINE). While these genes may take advantage of their border position to be ubiquitously expressed, they are not directly linked with TAD edge formation. The specific molecules identified at boundaries of TADs are called insulators or architectural proteins because they not only block enhancer leaky expression but also ensure an accurate compartmentalization of cis-regulatory inputs to the targeted promoter.
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Glutamine (Q)-rich TADs are found in POU2F1 (Oct1), POU2F2 (Oct2), and Sp1 (see also Sp/KLF family). Although such is not the case for every Q-rich TAD, Sp1 is shown to interact with TAF4 (TAFII 130), a part of the TFIID assembly.
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Moreover, CTCF and cohesin play important roles in determining TADs and enhancer-promoter interactions. The result shows that the orientation of CTCF binding motifs in an enhancer- promoter loop should be facing to each other in order for the enhancer to find its correct target.
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Multiple levels of mammalian genome organization. Chromosomes occupy discrete territories in the nucleus (left). Topologically associating domains (TADs) are regions of the genome with locally high interaction frequency (center). Insulated neighborhoods are loops formed by the interaction of CTCF/cohesin- bound anchors containing genes and their regulatory elements.
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The functions of TADs are not fully understood and still is a matter of debate. Most of the studies indicate TADs regulate gene expression by limiting the enhancer-promoter interaction to each TAD, however, a recent study uncouples TAD organization and gene expression. Disruption of TAD boundaries are found to be associated with wide range of diseases such as cancer, variety of limb malformations such as synpolydactyly, Cooks syndrome, and F-syndrome, and number of brain disorders like Hypoplastic corpus callosum and Adult-onset demyelinating leukodystrophy. The mechanisms underlying TAD formation are also complex and not yet fully elucidated, though a number of protein complexes and DNA elements are associated with TAD boundaries.
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Lockheed Martin signed the original TADS/PNVS production contract on 30 April 1982, and the first TADS/PNVS system was fielded in 1983. The Boeing Company and Lockheed Martin agreed to initiate the incorporation of new technology into the Arrowhead sensor system during July 2001. The heart of the project is a large-format staring array mid-wave (MW) forward-looking infrared (FLIR) sensor which uses the staring mid-wave integrated detector/cooler assembly (IDCA) used in Lockheed Martin's Sniper Advanced Targeting Pod. The upgrade is designed to complement the excellent obscurant penetration of the existing long-wave (LW) sensor with a longer- range, smaller-field-of-view MW sensor providing the Apache aircrew with enhanced electro-optical targeting performance in all conditions.
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Located in Tunis, Tunisia, at the headquarters of FAO sub-regional office, the RAHC-NA was created within the context of the Global Framework for the Progressive Control of Transboundary Animal Diseases (GF-TADS), signed on May 2004 between FAO and OIE. GF-TADS is an initiative to combine the experience and expertise of both organizations in the fight against Transboundary Animal Diseases in order to strengthen capacities of developing countries and assist them in setting specific control programs of certain Transboundary Animal Diseases according to priority areas. RAHC-NA is supported mainly by the Spanish Agency for International Cooperation for Development (AECID), but also by the Canadian International Development Agency (ACDI) and the Swedish International Development Cooperation Agency (SIDA).
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Although most strips involved strange creatures, the tads had a clash with a pair of aggressive suffragettes in the June 28, 1914 strip. He created a short-lived comic strip in 1910 called The Loony Lyrics of Lulu. These strips are about a girl who encounters imaginary creatures and writes (inoffensive) limericks about them.
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TADs are defined as regions whose DNA sequences preferentially contact each other. They were discovered in 2012 using chromosome conformation capture techniques including Hi-C. They have been shown to be present in multiple species, including fruit flies (Drosophila), mouse, plants, fungi and human genomes. In bacteria, they are referred to as Chromosomal Interacting Domains (CIDs).
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Mounted above the TADS, the Pilot Night Vision System (PNVS) contains an infrared camera slaved to the head movements of the pilot. PNVS can rotate +/− 90 degrees in azimuth and +20/− 45 degrees in elevation. PNVS has a high rate of movement (120° per second) so as to accurately match the head movements of the pilot.
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AH-64 Apache in flight One of the revolutionary features of the Apache was its helmet mounted display, the Integrated Helmet and Display Sighting System (IHADSS); among its capabilities, either the pilot or gunner can slave the helicopter's 30 mm automatic M230 Chain Gun to their helmet, making the gun track head movements to point where they look. The M230E1 can be alternatively fixed to a locked forward firing position, or controlled via the Target Acquisition and Designation System (TADS). On more modern AH-64s, the TADS/PNVS has been replaced by Lockheed Martin's Arrowhead (MTADS) targeting system. U.S. Army engagement training is performed under the Aerial Weapons Scoring System Integration with Longbow Apache Tactical Engagement Simulation System (AWSS- LBA TESS), using live 30 mm and rocket ammunition as well as simulated Hellfire missiles.
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Uncle Zebulon's Will is a 1995 work of interactive fiction by Magnus Olsson, in which the player-character plays the nephew of a crackpot scientist, exploring his home and solving magic-based puzzles. It won the TADS category at the inaugural 1995 Interactive Fiction Competition. The game was included on Activision's 1996 commercial release of Classic Text Adventure Masterpieces of Infocom.
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The project cost was described as US$5 million. The helmet-controlled gun turret and Target Acquisition and Designation Sights, Pilot Night Vision System (TADS/PNVS) is similar to that of the AH-64 Apache, which uses an "Integrated Helmet And Display Sight System" (IHADSS), wherein the nose-mounted sensors and the 30 mm chain gun are linked to the gunner's helmet.
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In humans, a scissor bite does have any significant influence on the facial profile. However, the chewing habits is influenced due to no contact of molars. Treatment of scissor bite may involve expansion device of the lower arch, usage of cross-elastics in an orthodontic treatment. A new method of using Temporary Anchorage Devices (TADs) has been shown to correct the scissor bite in humans.
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Data from high-throughput chromosome conformation capture experiments, such as Hi-C (experiment) and ChIA-PET, can provide information on the spatial proximity of DNA loci. Analysis of these experiments can determine the three-dimensional structure and nuclear organization of chromatin. Bioinformatic challenges in this field include partitioning the genome into domains, such as Topologically Associating Domains (TADs), that are organised together in three-dimensional space.
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If there are many previous messages, fast- forwarding through them can cause a significant delay. This delay is taken care of by playing back a beep to the caller, when the TAD is ready to record. This beep is often referred to in the greeting message, requesting that the caller leave a message "after the beep". TADs with digital storage for the recorded messages do not show this delay, of course.
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Two characteristics define CIDs or TADs. First, genomic regions of a CID physically interact with each other more frequently than with the genomic regions outside that CID or with those of a neighboring CID. Second, the presence of a boundary between CIDs that prevents physical interactions between genomic regions of two neighboring CIDs. The E. coli chromosome was found to consist of 31 CIDs in the growth phase.
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It has been shown that condensin, a large protein complex that plays a central role in mitotic chromosome assembly, induces positive supercoils in an ATP hydrolysis- dependent manner in vitro. Supercoiling could also play an important role during interphase in the formation and maintenance of topologically associating domains (TADs). Supercoiling is also required for DNA/RNA synthesis. Because DNA must be unwound for DNA/RNA polymerase action, supercoils will result.
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Circular plot of the bipartite mouse X chromosome, generated by the Epigenome Browser. Image from The different 3C-style experiments produce data with very different structures and statistical properties. As such, specific analysis packages exist for each experiment type. Hi-C data is often used to analyze genome-wide chromatin organization, such as topologically associating domains (TADs), linearly contiguous regions of the genome that are associated in 3-D space.
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Head-on view of the LCH with underwing rocket pods mounted on its stub wings The LCH is furnished with a glass cockpit which accommodates an Integrated Avionics and Display System (IADS) which used an array of multifunction displays in conjunction with the onboard target acquisition and designation (TADS) system. A prominent element of the TADS system is the helmet mounted sight (HMS), which serves as the principal instrument for targeting and triggering the rotorcraft's armaments. The LCH is protected via an extensive electronic warfare suite which is provided by the South African division of Saab Group; this suite comprises various defensive elements to guard against several different threats, these include a radar warning receiver (RWR), laser warning receiver (LWR) and a missile approach warning (MAW) system. The LCH is equipped with an integrated data link, which enables the type to participate in network-centric operations by facilitating the transfer of mission data to other platforms, comprising both airborne and ground-based elements.
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Updated in 2009. Unlike voicemail, which can be a centralized or networked system that covers, and mostly extends, similar functions, an answering machine is set up in the user's premises alongside—or incorporated within—the user's land-line telephone. Unlike operator messaging the caller does not talk to a human. As landlines become less important, due to the shift to cell phone technology, and as unified communications matures, the installed base of TADs is shrinking.
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The spatial arrangement of the chromatin within the nucleus is not random - specific regions of the chromatin can be found in certain territories. Territories are, for example, the lamina-associated domains (LADs), and the topologically associating domains (TADs), which are bound together by protein complexes. Currently, polymer models such as the Strings & Binders Switch (SBS) model and the Dynamic Loop (DL) model are used to describe the folding of chromatin within the nucleus.
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Successful psychotherapy appears to prevent the recurrence of depression even after it has been terminated or replaced by occasional "booster" sessions. The same degree of prevention can be achieved by continuing antidepressant treatment. Two studies suggest that the combination of psychotherapy and medication is the most effective way to treat depression in adolescents. Both TADS (Treatment of Adolescents with Depression Study) and TORDIA (Treatment of Resistant Depression in Adolescents) showed very similar results.
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Several algorithms have been developed to identify TADs from Hi-C data. Hi-C and its subsequent analyses are evolving. Fit-Hi-C is a method based on a discrete binning approach with modifications of adding distance of interaction (initial spline fitting, aka spline-1) and refining the null model (spline-2). The result of Fit-Hi-C is a list of pairwise intra-chromosomal interactions with their p-values and q-values.
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The competition is organized by Stephen Granade. Although the first competition had separate sections for Inform and TADS games, subsequent competitions have not been divided into sections and are open to games produced by any method, provided that the software used to play the game is freely available. Anyone can judge the games, and anyone can donate a prize. Almost always, there are enough prizes donated that anyone who enters will get one.
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In case of voice-only environments any accepted call can be directly handed over to a TAD, which may be preemptively superseded by a human-operated handset, taking control by simply going off-hook itself, forcing the TAD (back) on-hook. Voice signals may simply be captured to and replayed from analogue media (mostly tapes), but later TADs shifted to digital storage, with all of its convenience for compression and handling, for both the greeting and for the recorded messages.
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TADS resulted in 71% of their teen subjects having "much" or "very much" improvement in mood over the 61% with medication alone and 43% with CBT alone. Similarly, TORDIA showed a 55% improvement with CBT and drugs versus a 41% with drug therapy alone. However, a more recent meta-analysis of 34 trials of 14 drugs used with children and adolescents found that only fluoxetine produced significant benefit compared to placebo, with a medium sized effect (standardize mean difference = .5).
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British Apache pilot with IHADSS The AH-64 was designed to perform in front-line environments, and to operate at night or day and during adverse weather conditions. Various sensors and onboard avionics allows the Apache to perform in these conditions; such systems include the Target Acquisition and Designation System, Pilot Night Vision System (TADS/PNVS), passive infrared countermeasures,Richardson and Peacock 1992, pp. 26–31. GPS, and the IHADSS. Longbow-equipped Apaches can locate up to 256 targets simultaneously within .
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This C-terminal region spans the last 150 amino acids of the HSF1 protein and contains 2 TADs (TAD1 and TAD2). TAD1, which sits at amino acids 401-420, is largely hydrophobic and is predicted to take on an alpha-helical conformation. TAD1 has been shown to directly interact with target DNA to direct HSF1's transcriptional activation. The structure of TAD2, amino acids 431-529, is not expected to be helical as it contains proline residues in addition to hydrophobic and acidic ones.
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In 1987, Michael J. Roberts released TADS, a programming language designed to produce works of interactive fiction. In 1993, Graham Nelson released Inform, a programming language and set of libraries which compiled to a Z-Code story file. Each of these systems allowed anyone with sufficient time and dedication to create a game, and caused a growth boom in the online interactive fiction community. Despite the lack of commercial support, the availability of high quality tools allowed enthusiasts of the genre to develop new high quality games.
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A pilot strip was published on October 4, 1903. The format of the strip put extreme restrictions on the use of word balloons (even with the use of ambigrams only three strips used word-balloons, all in March 1904). Although the July 10, 1904, strip implies that the stories are set in America, Verbeek filled his milieu with African animals and peoples, fabulous monsters, fairy castles, etc. Verbeek's longest-running strip was The Terrors of the Tiny Tads, published by the Herald from May 28, 1905, to October 28, 1914.
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Self-interacting (or self-associating) domains are found in many organisms – in bacteria, they are referred to as Chromosomal Interacting Domains (CIDs), whereas in mammalian cells, they are called Topologically Associating Domains (TADs). Self-interacting domains can range from the 1–2 mb scale in larger organisms to 10s of kb in single celled organisms. What characterizes a self-interacting domain is a set of common features. The first is that self-interacting domains have a higher of ratio of chromosomal contacts within the domain than outside it.
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In 1995, Harmon received the North Carolina Architecture Foundation’s Kamphoefner Prize for Distinguished Design Over a Ten-Year Period. The Raleigh News & Observer named him "Tarheel of the Week" in 2005. A fellow of the American Institute of Architects, he is also a founding member of the Triangle Architecture Design Society (TADS). Harmon presented "Architects Discuss America’s New Regionalism" during the 2005, 2006, and 2007 National AIA Conventions, and was an invited speaker for Dwell Magazine’s Dwell On Design Conference in San Francisco. He was subsequently featured in Dwell’s "Conversations" sections.
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In mammalian biology, insulated neighborhoods are chromosomal loop structures formed by the physical interaction of two DNA loci bound by the transcription factor CTCF and co-occupied by cohesin. Insulated neighborhoods are thought to be structural and functional units of gene control because their integrity is important for normal gene regulation. Current evidence suggests that these structures form the mechanistic underpinnings of higher-order chromosome structures, including topologically associating domains (TADs). Insulated neighborhoods are functionally important in understanding gene regulation in normal cells and dysregulated gene expression in disease.
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Senescent cells undergo chromatin landscape modifications as constitutive heterochromatin migrates to the center of the nucleus and displaces euchromatin and facultative heterochromatin to regions at the edge of the nucleus. This disrupts chromatin-lamin interactions and inverts of the pattern typically seen in a mitotically active cell. Individual Lamin-Associated Domains (LADs) and Topologically Associating Domains (TADs) are disrupted by this migration which can affect cis interactions across the genome. Additionally, there is a general pattern of canonical histone loss, particularly in terms of the nucleosome histones H3 and H4 and the linker histone H1.
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In addition to entrapping DNA to ensure proper chromosome segregation during the cell cycle, SMC1A, as a component of cohesin, contributes to facilitating inter-chromatid contacts mediating distant-element interactions and to creating chromosome domains called topologically associating domains (TADs). It has been proposed that cohesin promotes the interaction between enhancers and promoters for regulating gene transcription regulation. The removal of cohesin triggers abnormal TAD topology because loops spanning multiple compartment intervals lead to mixing among loci in different compartments As a consequence, loop loss causes gene expression dysregulation. SMC1A also plays a role in spindle pole formation.
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Sunday Press Books released a deluxe landscape-format hardcover volume called Little Sammy Sneeze: The Complete Color Sunday Comics 1904–1905 in 2007. On the reverse of each Sammy Sneeze page appears a non-Sammy Sneeze strip—the complete run of McCay's The Story of Hungry Henrietta, as well as selections from John Prentiss Benson's The Woozlebeasts, and Gustave Verbeek's The Upside-Downs of Little Lady Lovekins and Old Man Muffaroo and The Terrors of the Tiny Tads. These bonus strips appear in monochrome to Sammy Sneezes color, as newspapers at the time normally printed color on only one side of the page.
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An endless-loop outgoing message tape used in dual- cassette-based answering machines Most modern answering machines have a system for greeting. The owner may record a message that will be played back to the caller, or an automatic message will be played if the owner does not record one. This holds especially for the TADs with digitally stored greeting messages or for earlier machines (before the rise of microcassettes) with a special endless loop tape, separate from a second cassette, dedicated to recording. There have been answer-only devices with no recording capabilities, where the greeting message had to inform callers of a state of current unattainability, or e.g.
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With options, this would bring the total number of Arrowhead kits and/or systems to 785."Lockheed Martin Awarded $172 Million Arrowhead Production Contract" . Lockheed Martin, 7 April 2008. Retrieved 18 July 2011 An order for 55 Lot 6 Arrowhead systems was placed in 2009 for $142 million."Army contracts for LM Arrowhead kits" UPI 29 July 2009 Lockheed Martin announced a $260 million follow-on production contract for Production Lot 7 on 17 August 2010. By the end of Lot 7, which extends production through April 2013, over 1,000 kits will have been delivered."Lockheed Martin Receives $260 Million M-TADS/PNVS Production Contract".
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A passive TPA solidarizes the two molars or the two posterior segments, thus preventing any individual independent movement, as for example molar rotation or tipping due to alignment wires, loops or cantilevers, and this is a kind of anchorage source, however, cannot prevent the movement of the 2 molars as a group, as in the case of premolar space closure. TPA is also used to prevent buccal tipping of the molars when a Burstone-type Segmental Arch mechanics are being used. In a case of open bite, TPA can be used to maintain the molar position when TADs are being used to intrude the upper molars to close the open bite.
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In recent years, the advent of a molecular method called chromosome conformation capture (3C) has allowed studying a high-resolution spatial organization of chromosomes in both bacteria and eukaryotes. 3C and its version that is coupled with deep sequencing (Hi-C) determine physical proximity, if any, between any two genomic loci in 3D space. A high-resolution contact map of bacterial chromosomes including the E. coli chromosome has revealed that a bacterial chromosome is segmented into many highly self- interacting regions called chromosomal interaction domains (CIDs). CIDs are equivalent to topologically associating domains (TADs) observed in many eukaryotic chromosomes, suggesting that the formation of CIDs is a general phenomenon of genome organization.
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In 1976 he moved to Terrace in northern B.C., where he worked as an instructor in the English department at Coast Mountain College. In 1992 he moved back to Vancouver to teach at Capilano College. During this period, Stanley published books and was active in Canadian politics, unions, and the alternative media, and served as a board member of the Capilano Press Society, publisher of The Capilano Review. He also edited and contributed to the intergenerational Vancouver literary journal Tads (1996-2001), through which Stanley, George Bowering, Jamie Reid, and Renee Rodin mentored younger writers such as Thea Bowering, Wayde Compton, Reg Johanson, Ryan Knighton, Jason Le Heup, Chris Turnbull, and Karina Vernon.
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The system was also physically larger and heavier than had been anticipated, rendering it less easily transportable.Stephens, Soing Solo, p. 393 In 1979, No. 114 MCRU upgraded to the Westinghouse AN/TPS-43 radar system, improving both its mobility and its tactical capabilities. It inaugurated the RAAF's Tactical Air Defence System (TADS, subsequently Tactical Air Defence Radar System or TADRS) on 10 July 1985. No. 114 MCRU was presented with a Squadron Standard on 23 May 1990, becoming the only non- flying unit in the Air Force to receive such an honour. The standard displays battle honours for the Pacific (1943–45), New Britain (1943), New Guinea (1943–44) and Borneo (1945).
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People whose native language is not English are particularly affected by syntax guessing. Text Adventure Development System (TADS) games supply a fair list of verbs commonly used in their documentation. If the game designer uses new actions not covered in this list, and which cannot easily be inferred by the purpose and context of the object, the player will probably encounter syntax problems. A similar problem can occur when attempting to accomplish a game goal using a certain combination of actions, locations and objects, which may appear rational and legitimate to the player, and are accepted by the game, only to be incorrectly handled and resulting in a gameplay error or game crash.
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The 17-amino-acid-long trans-activating domains (TAD) of several transcription factors were reported to bind directly to TAF9: p53, VP16, HSF1, NF-IL6, NFAT1, NF-κB, and ALL1/MLL1. Inside of these 17 amino acids, a unique Nine-amino-acid transactivation domain (9aaTAD) was identified for each reported transcription factor. 9aaTAD is a novel domain common to a large superfamily of eukaryotic transcription factors represented by Gal4, Oaf1, Leu3, Rtg3, Pho4, Gln4, Gcn4 in yeast and by p53, NFAT, NF-κB and VP16 in mammals.The prediction for 9aa TADs (for both acidic and hydrophilic transactivation domains) is available online from National EMBnet- Node Austria () TAF9 is supposed to be a universal transactivation cofactor for 9aaTAD transcription factors.
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Anne Marie Albano's research focuses on anxiety and mood disorders. She aims to raise awareness about the importance of children's mental health and how positive mental health is essential to a child's healthy development. Albano founded and directs the Columbia University Clinic for Anxiety and Related Disorders (CUCARD), an evidence-based treatment clinic that provide cognitive behavioral therapy for patients with anxiety and mood disorders. Albano was the primary investigator for two National Institute of Mental Health funded clinical studies, The Child/Adolescent Anxiety Multimodal Study (CAMS) and the Treatments for Adolescents with Depression Study (TADS), that examined the benefits of cognitive behavioral therapy, medication, and the combination of both for treating children and adolescents with anxiety and related disorders.
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The hermaphroditic himatids (the name is derived from the Greek himation, a cloak) have evolved on Genji's predominantly oceanic starside. Their basic form is the ribbon or plate which takes in nourishment and oxygen on its lower (ventral) side, and excretes on the upper (dorsal) side. Their life cycle starts with caterpillar-sized "wrigglers" which swim ashore and adopt a slug-like existence, growing by addition of cell layers to become "tads." Once they have reached a size of about 40 x 10 cm and are too big to get around readily on land, they follow chemical clues to the tidelands where they join older juveniles, the "calves" which are fully intelligent, mostly aquatic, live in bands, and have a culture about which little is known (and even less understood) by human researchers or by the Ihrdizu which used to enslave them.
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The Hellenic Air Force was the first European air force to receive the Freedom Fighter. The first F-5As were delivered in 1965, and over the next 8 years a total of about 70 F-5A/Bs were operational. The Hellenic Air Force bought an additional 10 F-5A/Bs from Iran in 1975, and around the same period another batch of 10 F-5A/Bs were acquired from Jordan. Another 10 were acquired from Norway in 1986, and a final 10 NF-5As were purchased from the Netherlands in 1991. The total number of F-5s in operation (including the ex-Iranian machines, 34 RF-5As, and 20 F-5Bs) in the Hellenic Air Force was about 120 aircraft, from 1965 to 2002, when the last F-5 was decommissioned and the type went out of operation in the Hellenic Air Force. AeroGroup, a private commercial company in the US, operates the CF-5B as a fighter lead-in aircraft for training and for other support services. There were 17 aircraft originally purchased from the Canadian Government with U.S. State Department approval and then imported into the US in 2006."TADS (Tactical Air Defense Services, Inc." A-4 Skyhawk Association.
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