There's also a company called OhMiBod, they do vibrators and sexual stimulators.
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For the last three years, I have been studying D.I.Y. brain stimulators.
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He was 14 at the time and was playing drums for the Stimulators.
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These devices, called epidural stimulators, have been used for years to treat chronic pain.
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Clinician-scientists have created stimulators that treat patients and simultaneously monitor patient brain function.
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In some cases, implanted devices called deep-brain stimulators can also help with symptoms.
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I was amazed at how approachable he and the rest of the Stimulators were.
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People with labias almost always find the best success when starting with clitoral stimulators like bullets.
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Slip on these shoes and attach the stimulators for a highly specific release of aching feet.
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And like pacemakers, brain stimulators are now small enough to be surgically inserted with relative comfort.
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Abbott Laboratories and Boston Scientific also began selling deep brain stimulators within the last few years.
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Johnson does offer g-spot stimulators, but their most popular vibrator—the Rabbit—also provides clitoral stimulation.
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If that's not your cup of tea, strap some electric stimulators onto your biceps while you're pumping iron.
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They also played The Outcasts' concert film Self-Conscious Over You, and between the two flicks the Stimulators performed.
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Even without steps, the epidural stimulators seem to have other benefits, including an improvement in bowel, bladder, and sexual function.
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At first, they told me the study was focused on just using electronic stimulators on my muscles in my forearms.
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After the separate technologies were implanted, the researchers connected Kochevar's brain-computer interface to the electrical stimulators in his arm.
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"To me," said Dr. Voytek, the new approach "is a clear demarcation that the era of dumb stimulators is over."
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On one level, it's just a much smaller version of the deep brain stimulators and other neuromodulators currently on the market.
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The BigoDicky was an ill-fated crowdfunding project: A sports bra and shorts set outfitted with a dildo and nipple stimulators.
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And while D.I.Y. brain stimulators are often characterized as reckless and foolhardy, my research has led me to view them differently.
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There's some overlap between the two companies' offerings, including spinal cord stimulators, which are implantable devices used to treat chronic pain.
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Then, its electric muscle stimulators will work to improve blood flow, release endorphins, and relieve any aches and pains ailing you.
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"At a thousand bucks a pop, these stimulators aren't toys and they aren't cheap," said trainer and physique athlete Douglas Alexander.
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The FDA's reluctance to approve electrical muscle stimulators for fat reduction, even though they do work your muscles, is testament to that.
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In one recent study, these so-called SPG stimulators relieved pain in two-thirds of the cluster headache patients who tried them.
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These included three relaxers, three anti-frizz agents, a hot-oil treatment, six lotions, a leave-in conditioner, and four root stimulators.
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Available in three forms – a butt plug and two wearable clitoral stimulators – each product features a small mic that turns surrounding noise into vibrations.
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Sometimes, bone stimulators are used; these are external devices which can speed healing, especially in a bone that has not healed despite adequate treatment.
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He was one of nine patients, all good swimmers despite having Parkinson's, who had the same strange, dangerous side effect from deep brain stimulators.
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Despite the effect on swimming, he said all nine patients preferred to keep their stimulators on, because they provided so much relief from symptoms.
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We do not want sport to become competition between different kinds of stimulators, most of which are highly dangerous for athletes' health, do we?
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Epidural stimulators are made by several companies including Medtronic, which provided the equipment for the NEJM study but did not otherwise provide funds or input.
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The next big wellness craze might be "transcranial stimulators" — brain-jolting helmets that give us the burning desire to, say, practice piano all the time.
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Alongside the bristles are soft rubber gum stimulators that can help massage the connective tissue of your gums, stimulating blood flow to rejuvenate the gums.
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It made a name for itself by creating clitoral stimulators that are not only fantastic toys, but also double as gorgeously sophisticated pieces of jewelry.
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There's a bike race where participants, paraplegics, have implants in their legs or external stimulators that flex their muscles in the pattern necessary to pedal a bike.
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Deep brain stimulators, first introduced more than 20 years ago, emit electrical signals that interfere with the abnormal electrical impulses in the brain that cause Parkinson's symptoms.
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But instead of just dried plants, it also uses state-of-the-art electric muscle stimulators to relieve aches, improve your blood flow, and even soothe your mind.
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The tiny device on display at CES 2016 is one of the latest in a new trend of sex toys for women called suction oral sex stimulators. It's...
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Fiera Arouser for Her, on display at CES 2016, is one of the latest in a new trend of sex toys for women called suction oral sex stimulators.
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The Australian doctors said that three other patients with stimulators for Parkinson's had drowned, and that they did not know if the deaths were related to the device.
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TENS Unit O.K., so yes, these kind of look like those gimmicky electronic muscle stimulators from the '90s that promised abs without the work, but the similarities end there.
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Future deep brain stimulators may even include sensors that allow it to respond dynamically to changes in brain patterns, said Brett Wall, senior vice president of brain therapies at Medtronic.
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Three of them tried turning off the stimulators, and immediately could swim again, according to an article in the journal Neurology by a medical team from the University of Zurich.
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He said other complicated, learned skills might also be affected: Some patients said they could no longer ski after receiving stimulators, and one said he could not play golf anymore.
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Muscle stimulators are relatively old devices, and have a checkered history—ineffective and at times dangerous electric "training belts" were sold to gullible trainees at the turn of the century.
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During the late 22001s, he was playing drums in the influential punk band the Stimulators, and then in the early '255s he founded an even more influential band, the Cro-Mags.
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The company said it had also notified the Food and Drug Administration, changed the labeling for the stimulators and sent the notice to 2,400 doctors who treated patients with the devices.
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The device shouldn't be used if you have any other implants or metallic devices in or near your head, such as cochlear implants, stents, aneurysm clips or coils, and vagus nerve stimulators, among others.
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I have conducted long interviews with dozens of D.I.Y. stimulators, both in person and via Skype; collected hundreds of questionnaire responses; and tracked online forums, websites, blogs and other platforms on which practitioners communicate.
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In addition to the bi-directional brain implant devices, the researchers at the Center have also been working on improving existing implantable tech, such as the deep brain stimulators that are used to treat Parkinson's disease.
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He explained that the key to the device is TENS (transcutaneous electrical nerve stimulation), those electronic nerve stimulators you've probably seen in strip malls that hook up to the body to treat neck or back pain.
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Womanizer PremiumFrom: Ella ParadisDespite the eyebrow-raising name, the Womanizer remains one of the most popular clitoral stimulators on the market, and is unsurprisingly continuing to reign supreme as we spend more time in our homes.
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A research team at the Hasso Plattner Institut in Germany created a wearable system that uses an array of electronic muscle stimulators to trick a user into thinking that a wall in VR is providing real resistance.
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The earlier Australian report prompted Medtronic to post an "urgent field safety notice" in 2016, warning that a side effect of brain stimulators could be a loss of coordination that might leave a patient unable to swim.
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What that translated to was sitting in a lounge chair with a "proprietary formula" calming cream dabbed on my neck and micro-current stimulators placed on top, a blackout eye mask and headphones with calm music playing.
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About 32 million Americans — or about one in 10 — have at least one medical device implanted, from artificial joints to cardiac stents, surgical mesh, pacemakers, defibrillators, nerve stimulators, replacement lenses in eyes, heart valves and birth control devices.
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In any case, he said, all Parkinson's patients, whether they have stimulators or not, should be warned not to swim alone, because the disease itself can make them suddenly unable to move and put them at risk for drowning.
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One thing that could shift all of these would be to make the entire system wireless, so you could have a sensor in your brain talking to stimulators placed all over your body—not just your hands, but also your legs and feet.
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"There are several stimulators of chronic inflammation, and diet is one of those factors that can constantly stimulate the body toward a more chronic inflammatory state," said lead study author Fred Tabung, a research associate in the department of nutrition at Harvard.
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The value of the signal activates the nerve stimulators via radio frequency which then sends an electrical sensation through the arms of the controlled bodies forcing them to move based on when the first individual sends a brain signal to move their own arm.
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Two other men involved in the study were also able to regain control of their leg muscles after they were implanted with electrical stimulators that could help compensate for the damage to their spinal cords, according to new research published in the journal Nature.
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Called the "Implant Files," the extensive analysis of pacemakers, insulin pumps, breast implants, spinal cord stimulators and other surgically embedded appliances and materials found nearly 83,000 deaths and more than 1.7 million injuries possibly linked to medical devices and reported in the United States alone since 2008.
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The annual event allows fans to get up close and personal with anyone who is anyone in the adult industry as well as buy every manner of odd and obscure sex toy on the market from horse-sized riding stimulators to sci-fi themed massive dildos.
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While some experimental treatments such as cell transplants and implants of electrical stimulators could help paralyzed people walk again, Dr. Ida Fox, a physician and a surgery professor at the Washington University in St Louis, said that nerve transfers are safe, reliable and circumvented risky spine-level surgery.
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After months of arduous training after the epidural stimulators were put into place, the patients have been able to recover at least some ability to take steps — and, in one woman's case, actually use a walker instead of a wheelchair, at least some of the time while at home.
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Combining the best of modern technology with ancient techniques, this iJoou Smart Moxibustion Thermotheraphy Device uses a form of acupuncture that improves the flow of energy in the body by heating dried plant materials called "moxa," and using electric muscle stimulators to activate nerves and release pain-blocking endorphins.
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The facial begins with a red wine-based cleanser — which smelled amazing — and is followed by a serum that contains the antioxidants from red grapes combined with collagen stimulators, hydrators, firming properties and soothing elements to boost skin cells, followed by a red wine extract eye cream to lock in moisture.
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In a series of simple experiments that involved catching a dropped marker, photographing a high-speed object in motion, and shooting a baseball out of the air, the researchers used a combination of sensors to detect the event and connected electrical muscle stimulators to trigger a reaction in the subject.
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Through trial and error, the researchers found that by limiting the activation of the electrical muscle stimulators to around 160 milliseconds after the trigger event, a subject's reaction times could be sped up by almost 80 milliseconds while still making them feel like they were in complete control of their bodies.
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For years physical therapists have used electric muscle stimulators to help patients rehabilitate or strengthen their muscles, and similarly, the new device sends little electric shocks to sensors on your arms that stimulate your muscles whenever you press against a wall or try to lift a heavy object in virtual reality.
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It was pure madness, even for a street smart pre-teen whose day-to-day existence in the late 70s centered on finding stores that were easy to shoplift food from, bathing in fire hydrants, and playing in punk rock bands, first as a drummer with The Stimulators, and later as a bassist for the Cro-Mags—the band that came to define New York hardcore.
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Some of the techniques include implantation of deep brain stimulators, spinal cord stimulators, peripheral stimulators and pain pumps. Surgery of the peripheral nervous system is also possible, and includes the very common procedures of carpal tunnel decompression and peripheral nerve transposition. Numerous other types of nerve entrapment conditions and other problems with the peripheral nervous system are treated as well.
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The case identified the high risk associated with the usage of root stimulators.
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This idea spawned a whole new type of mechanical device known as the "trade stimulators".
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Nerve conduction studies are very helpful to diagnose certain diseases of the nerves of the body. The test is not invasive, but can be painful due to the electrical shocks. The shocks are associated with a low amount of electric current so they are not dangerous to anyone. Patients with a permanent pacemaker or other such implanted stimulators such as deep brain stimulators or spinal cord stimulators must tell the examiner prior to the study.
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The Stimulators are a German band who do mostly their own material or completely remodel songs by other composers when they cover them. The six- piece band fuses Latin, Blues, Ska, Jazz, Reggae and Rock into a sound that is unique to the Stimulators.
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The question of whether 144 tactile stimulators on a fingertip could be independently distinguished led to a confrontation at a scientific conference between Bliss and Frank Geldard, a University of Virginia professor. Geldard had written a major book on the human senses and was a leading researcher on using the sense of touch to communicate information. When asked how many tactile stimulators should be used in a tactile display, he maintained that no more than 8 tactile stimulators could be independently distinguished, and these should be on widely separated parts of the body. Bliss’ data showing useful reading with 144 stimulators on a fingertip appeared to be in conflict with Geldard's research.
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Commercial stimulators can typically achieve any of the four levels of stimulation, though some stimulators may be more adept at a certain levels of stimulation than others. Transcutaneous electrical nerve stimulation (TENS) is an umbrella term used to characterize all forms of electroanalgesia utilizing surface electrodes applied to the skin.
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The lumbar anterior root stimulator is similar in nature to Brindley's sacral anterior root stimulator. The difference in nomenclature is derived from which nerve roots on the spinal cord are being electrically stimulated. However the two types may be used in conjunction and may be referred to as sacro-lumbar root stimulators or lumbo- sacral root stimulators which seem to be the most researched in literature. The stimulators are implanted from the anterior side due to easier access of the spine below the cervical vertebrae.
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In his book American Hardcore: A Tribal History, scene historian Steven Blush stated that the "Stimulators triggered the rise of NYHC. In 1980-1981, 50 or so ragtag kids attended their shows at Max's, CBs, or TR3, but those kids formed the roots of the NYHC scene." Blush also noted that the Stimulators befriended Washington D.C.'s Bad Brains, who proceeded to make NYC their second home, another hugely influential development in the history of NYHC. The two bands would be featured in cassette-only label ROIR's 3rd (Stimulators) and 4th ever releases.
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The stimulators and liquid nutrients of Atami are packed and sealed lighttight under the twistable cap, so the quality remains guaranteed.
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Pisolithus arhizus is a major component in mycorrhizal fungus mixtures that are used in gardening as powerful root stimulators. It is inedible.
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Stimulators, in turn, may be used to stimulate the muscle and treat motor control loss in order to regain function in the limbs.
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Peak amplitudes are typically below 1 mA and do not produce phase charges strong enough to excite peripheral nerve fibers and reach the sensory threshold. Stimulators that work at this level are termed microcurrent electrical nerve stimulators (MENS). In addition to the low amplitudes, pulse durations are short, thereby activating neither the muscle nor the nerve. No studies have shown clinical effectiveness of subsensory-level stimulation.
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Many agents stimulate cells and tissues to produce 20-HETE in vitro and in vivo. Androgens are particularly potent stimulators of this production. Other stimulators include the powerful vasoconstriction-inducing agents, angiotensin II, endothelins, and alpha adrenergic compounds (e.g. norepinephrine). Nitric oxide, carbon monoxide, and superoxide inhibit 20-HETE production; these non-pharmacological agents do so by binding to the Heme binding site of the 20-HETE producing cytochrome p450 enzymes.
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From the late 18th century to today many milestones have been developed. Nowadays, sensory prosthetic devices, such as visual implants, cochlear implants, auditory midbrain implants, and spinal cord stimulators and also motor prosthetic devices, such as deep brain stimulators, Bion microstimulators, the brain control and sensing interface, and cardiac electro-stimulation devices are widely used. In 2013 the British pharmaceutical company GlaxoSmithKline (GSK) coined the term "electroceutical" to broadly encompass medical devices that use electrical, mechanical, or light stimulation to affect electrical signaling in relevant tissue types. Clinical neural implants such as cochlear implants to restore hearing, retinal implants to restore sight, spinal cord stimulators for pain relief or cardiac pacemakers and implantable defibrillators are proposed examples of electroceuticals.
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Among all these mechanoreceptors Pacinian corpuscle offers the highest sensitivity to high frequency vibration starting from few 10s of Hz to a few kHz with the help of its specialized mechanotransduction mechanism. There have been two different types of stimulators: electrotactile or vibrotactile. Electrotactile stimulators use direct electrical stimulation of the nerve ending in the skin to initiate the action potentials; the sensation triggered, burn, itch, pain, pressure etc. depends on the stimulating voltage.
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Jack Rabid and Dave Stein began publishing The Big Takeover in May 1980 as a fanzine dedicated to New York punk band the Stimulators. The pair had formed a garage band the previous month called Even Worse, originally playing mainly punk rock cover songs. Even Worse was quickly tapped to open a show for the Stimulators, and the publication followed."New York: Part One: Jack Rabid — 'Encyclopedia of Punk,'" Flipside, whole no.
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However, ECL cells are activated directly by ACh on M1 receptors from direct vagal innervation leading to histamine release. This pathway will be inhibited by atropine. Gastrin is transferred from a specific type of G cell in the gastric epithelium to the ECL cells by blood. Histamine and gastrin act synergistically as the most important stimulators of hydrochloric acid secretion from parietal cells and stimulators of secretion of pepsinogen from chief cells.
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He also developed sacral anterior root stimulators for bladder control in paraplegic patients. Brindley GS, Polkey CE, Rushton DN. Sacral anterior root stimulators for bladder control in paraplegia. Paraplegia. 1982 Dec;20(6):365-81. Trained in Cambridge and London Hospital, he saw service in the RAF before taking up academic appointments first in Cambridge and then at the University of London, authoring more than 100 scientific papers in a variety of subjects.
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13-HODE (and 9-HODE) are moderately strong stimulators of the directed migration (i.e. chemotaxis) of cow and human neutrophils in vitro whereas 13(R)-HODE (and 9(R)-HODE, and 9(S)-HODE) are weak stimulators of the in vitro directed migration of the human cytotoxic and potentially tissue- injuring lymphocytes, i.e. natural killer cells. These effects may contribute to the pro-inflammatory and tissue-injuring actions ascribed to 13-HODEs (and 9-HODEs).
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International Standard IEC 60601-2-10 Medical electrical equipment. Particular requirements for the safety of nerve and muscle stimulators Thus it can be used in a plane, except during take-off and landing.
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Root stimulators are far from being perfect as there are many potential complications. Approximately 18% of patients with root stimulators have reported issues with the device. Approximately 8% of stimulator reports are due to cerebrospinal fluid collecting around the stimulator which inhibits stimulator function and causes significant discomfort to the patient. Another 8% of cases are caused by receiver failure in which the patient is unable to use the stimulator effectively or is in some way "incompatible" with the implant.
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Fanzine editor Jack Rabid, who was a regular at punk shows at Max's Kansas City, noticed for the first time many young overtly punk-looking and behaving attendees at the establishment, at Stimulators gigs. This gave him comfort as nearly 30 year old neighbor Richard Hell would tease him when seeing his own punk outfits, declaring that it "was over". Rabid would in 1980 publish the first issue of The Big Takeover, named after a Bad Brains song. The periodical originally focused on The Stimulators, but is published to this day covering punk rock generally.
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Around the mid to late 1970s New York City was arguably the birthplace of punk rock with the Ramones and the scene at CBGB. While the next generation of punks emerged in places like Washington, D.C. (Bad Brains and Minor Threat) and California (Black Flag, Dead Kennedys) in the early 1980s, NYC was initially quiet. A few bands like The Mad and The Stimulators hinted at a new direction. The Stimulators featured Harley Flanagan on drums, and attracted some of what would become the NYHC scene to their shows.
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As mentioned previously, neurogenic bowel dysfunction tends to occur after some form of spinal cord injury in which nerves important to control of sphincter contraction, bowel movements, and bladder control are severed or damaged. Lumbar root stimulators have been used in order to treat bowel dysfunction by allowing the patient to regain control of both excretory muscles and organs. Regaining such motor control prevents further complications associated with NBD such as constipation, incontinence, and irritable bowel syndrome. However, lumbar anterior root stimulators are not effective for all gastrointestinal issues.
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Harley Flanagan returned from the Stimulators' 1980 Ireland tour with a shaved head and a skinhead identity, which proved influential to what became the New York Hardcore scene of the 1980s. Harley came up with the name Cro-Mags while still playing in the Stimulators and founded the band in 1982/83 when he wrote, played all instruments, sang and recorded the first Cro-Mags demos re-released by MVD 2018. Along with peers such as Vinnie Stigma and Jimmy Gestapo, Harley would go on to be one of the leading figures of the internationally notable 1980s New York hardcore scene. The first live performance for an embryonic form of Cro-Mags, with a lineup featuring Harley (under the name "Disco Smoothie") on bass, and members of Even Worse and Crucial Truth, took place at the Peppermint Lounge in 1980, opening for the Stimulators.
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It is one of the most potent stimulators of cardiac contractility yet identified, and plays a role in cardiac tissue remodeling. Apelin levels are increased in left ventricles of patients with chronic heart failure and also in patients with chronic liver disease.
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ROIR released early recordings by Bad Brains (Bad Brains), Beastie Boys, Einstürzende Neubauten (2X4), Flipper (Blow'n Chunks), MC5, GG Allin, New York Dolls, Suns of Arqa, Prince Far I, Television, The Legendary Pink Dots, Lee 'Scratch' Perry, The Stimulators, and The Skatalites (Stretching Out).
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Mechanistically, NCOA2 inhibited Wnt/β-catenin signaling through simultaneously upregulating inhibitors and downregulating stimulators of Wnt/β-catenin pathway. NCOA2 is a novel negative growth regulatory gene repressing the Wnt/β-catenin pathway in CRC, where recurrent fusion with LACTB2 contributes to its disruption.
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He is not a full-time member of The Stimulators, but since 2003 he has played on all of their albums and on a lot of their live shows. He is to the Stims kind of what Bobby Keys is to the Rolling Stones.
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PAK3 activity is stimulated by Dbl, Cdc42 and Cool-2, and by AP1 transcription factor. Stimulation of PAK3 activity by upstream stimulators such as Dbl or Cdc42 is inhibited by p50 (Cool-1) PAK3 activity is inhibited by FRAX597, a PAN inhibitor of PAKs.
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Neuromodulation also refers to an emerging class of medical therapies that target the nervous system for restoration of function (such as in cochlear implants), relief of pain, or control of symptoms, such as tremor seen in movement disorders like Parkinson's disease. The therapies consist primarily of targeted electrical stimulation, or infusion of medications into the cerebrospinal fluid using intrathecal drug delivery, such as baclofen for spasticity. Electrical stimulation devices include deep brain stimulation systems (DBS), colloquially referred to as "brain pacemakers", spinal cord stimulators (SCS) and vagus nerve stimulators (VNS), which are implanted using minimally invasive procedures, or transcutaneous electrical nerve stimulation devices, which are fully external, among others.
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Spinal cord stimulators use electrodes placed adjacent to but outside the spinal cord. The overall complication rate is one-third, most commonly due to lead migration or breakage but advancements in the past decade have driven complication rates much lower. Lack of pain relief occasionally prompts device removal.
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Where surgery is not recommended, further management options include new (including experimental) anticonvulsants, and vagus nerve stimulation. The ketogenic diet is also recommended for children, and some adults. Other options include brain cortex responsive neural stimulators, deep brain stimulation, stereotactic radiosurgery, such as the gamma knife, and laser ablation.
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Neuromodulation can be successful in treating IC/BPS symptoms, including pain. One electronic pain-killing option is TENS. Percutaneous tibial nerve stimulation stimulators have also been used, with varying degrees of success. Percutaneous sacral nerve root stimulation was able to produce statistically significant improvements in several parameters, including pain.
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Mercedes, Flanagan, and Marden have played reunion shows with the latter on vocals, notably opening for their old friends the Bad Brains on October 11, 2006, one of the last ever shows at CBGB. Mercedes and Marden recorded a song called "song about murder", which is about Hilly Kristal and CBGB, and references events in the Stimulators' heyday. The duo continue to collaborate on projects, but Mercedes has stated are unlikely to revive the Stimulators moniker: "that happened... you can't go home again." In 2018, Mercedes teamed up with Marden and former singer of the iconic 1960s girl group The Crystals, LaLa Brooks to work on a new project called Dae Lilies.
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Riociguat (trade name Adempas) is a drug by Bayer that is a stimulator of soluble guanylate cyclase (sGC). It is used to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of the class of sGC stimulators.
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Experts recommend psychological evaluation prior to placement. A diagnosis with a psychiatric disorder is not a strict contraindication to stimulator placement. However, treatment of the disorder prior to consideration of a trial placement is indicated. Delayed placement – Stimulators may have poor efficacy if placed many years after onset of chronic pain.
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Veinoplus technology is based on the principle of electrostimulation. Thanks to a 9V battery, the device delivers electrical impulses with low frequency and low voltage. Input power is below 0.3W and output power is under 0.05W. The difference between Veinoplus and others electrical muscle stimulators is due to the waveform of the impulses.
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A SCS may also be used for other chronic pain conditions such as chronic pancreatitis and familial Mediterranean fever. Other devices that have shown benefit in reducing pain include transcutaneous electrical nerve stimulators (TENS), targeted field stimulation, both used for somatic hyperalgesic states, external neuromodulation, pulsed radiofrequency ablation and neuraxial drug delivery systems.
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Class II devices include X-ray systems and physiological monitors. Class III devices require the most regulatory controls since the device supports or sustains human life or may not be well tested. Class III devices include replacement heart valves and implanted cerebellar stimulators. Many implants typically fall under Class II and Class III devices.
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The former C5MW site produced components for hip and knee joints, disc replacements in spine surgery, seeds for brachytherapy, cochlear implants, neuro-stimulators, neuro-sensors and crowns, bridges, abutments and implants for dental applications."C5 Medical Werks Reaches Million Mark," Ceramic Industry, 11 Aug 2008. The Colorado plant added ceramic injection molding capabilities in 2008.
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The mechanism of blood vessel formation by angiogenesis is initiated by the spontaneous dividing of tumor cells due to a mutation. Angiogenic stimulators are then released by the tumor cells. These then travel to already established, nearby blood vessels and activates their endothelial cell receptors. This induces a release of proteolytic enzymes from the vasculature.
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Evidence from experimental disease models of arthritis, colitis, sepsis, hemorrhagic shock, and congestive heart failure indicate that electrical stimulation of the vagus nerve can prevent or reverse these diseases. It may be possible to implant nerve stimulators to replace anti-inflammatory drugs that target cytokine activity (e.g. anti-TNF and anti-IL-1 antibodies).
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While humans are highly dependent upon visual cues, when in close proximity smells also play a role in sociosexual behaviors. An inherent difficulty in studying human pheromones is the need for cleanliness and odorlessness in human participants. Experiments have focused on three classes of putative human pheromones: axillary steroids, vaginal aliphatic acids, and stimulators of the vomeronasal organ.
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Spinal Cord Stimulators are placed in two different stages: a trial stage followed by a final implantation stage. First, the skin is prepped and draped utilizing sterile technique. The epidural space is accessed with loss of resistance technique using a 14-gauge Tuohy needle. The lead is fed through carefully with fluoroscopic guidance to the appropriate spinal level.
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Hence, new tools rely on auditory and/or vibrotactile stimuli. Patients may wear headphones and/or vibrotactile stimulators placed on the wrists, neck, leg, and/or other locations. Another challenge is that patients may fade in and out of consciousness, and can only communicate at certain times. This may indeed be a cause of mistaken diagnosis.
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The devices, which have motorized joints, are put on over the legs and supply a source of power to move and walk. Several such devices are already available for sale, but investigation is still underway as to how they can be made more useful. Preliminary studies of epidural spinal cord stimulators for motor complete injuries have demonstrated some improvement.
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Cornelis William Hendrik Fuhler (3 July 1964 – 19 July 2020) was a Dutch/Australian improvisor, composer, and instrument builder associated with free jazz, experimental music and acoustic ecology. He played piano by manipulating sound with electromagnetic string stimulators like Ebows and motorized actuators. Fuhler also performed on guitar, turntables and synthesizer. He invented the keyolin, a combination of keyboard and violin.
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The Stimulators were an American punk rock band from New York City, United States. Although they have a limited discography, they are notable for being consistently cited as an important transitional band between the late-1970s New York City punk rock scene and New York hardcore, and for being the musical entry point for future Cro-Mags founder Harley Flanagan.
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Even Worse was formed in April 1980 by Summit, New Jersey punk rockers, Rabid and Stein, along with bassist Marden, as the direct result of the Stimulators needing an opening band for their May 1980 show at New York City club Tier 3. With singer Berry (later of the Young Aborigines and Beastie Boys), the teenage quartet performed at various Manhattan clubs, opening for the likes of Bad Brains. Eventually, Marden left to join the Stimulators and Berry and Stein likewise departed. Rabid recruited vocalist Korbet, bassist Keil and guitarist Weeks. This 1981-82 lineup of Even Worse performed at prominent New York City punk concerts and made their recorded debut with two songs on New York Thrash, a legendary document of the early '80s New York City punk and hardcore scene issued only on cassette by ROIR.
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At first, the Brains stayed with their NYC friends in the bands The Mad and The Stimulators. Their self-titled debut album was released on Neil Cooper's ROIR on "cassette only" on February 5, 1982, followed in 1983 by Rock for Light, produced by Ric Ocasek of The Cars. In 1985, Bad Brains' song "Pay to Cum" was featured in Martin Scorsese's film After Hours.
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Undead/Misfits/Whorelords guitarist Bobby Steele claims that Mercedes was one of the best ever punk guitarists, and one of the few true lead guitarists in the genre (this ability is also displayed in her more recent work in heavy metal tribute bands). Steele also asserts that the Stimulators were a formidable live act, and states that their recorded legacy does not reflect this.
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DNA vaccination generates an effective immune memory via the display of antigen-antibody complexes on follicular dendritic cells (FDC), which are potent B-cell stimulators. T-cells can be stimulated by similar, germinal centre dendritic cells. FDC are able to generate an immune memory because antibodies production “overlaps” long-term expression of antigen, allowing antigen-antibody immunocomplexes to form and be displayed by FDC.
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The final 2% is associated with some type of disease that requires removal of the device and puts the patient at great risk. Two major studies have been associated with issues in root stimulators. One twenty-nine-year-old male cervical spinal cord injury patient had severe complications with a sacral anterior root stimulator. The patient received the implant due to a traffic collision in 1978.
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Due to the difficulty detecting fade subjectively (TOF ratios between 0.4 and 0.9) when using peripheral nerve stimulators, clinicians are unable to reliably exclude residual neuromuscular blockade. TOF ratios >0.4 can be measured accurately and displayed numerically using quantitative neuromuscular monitoring. However, TOF ratios >4 can be measured accurately by using quantitative monitoring methods such as electromyography (EMG), kinemyography (KMG), phonomyography (PMG), and acceleromyography (AMG).
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Many of the 3-series prostanoids, the hydroxyeicosapentaenoic acids, and the 5-series LT have been shown or thought to be weaker stimulators of their target cells and tissues than their arachidonic acid-derived analogs. They are proposed to reduce the actions of their aracidonate-derived analogs by replacing their production with weaker analogs. Eicosapentaenoic acid-derived counterparts of the Eoxins have not been described.
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Medical devices such as pacemakers, insulin pumps, operating room monitors, defibrillators, and surgical instruments, including deep-brain stimulators, can incorporate the ability to transmit vital health information from a patient's body to medical professionals.Jordan Robertson. Associated Press 8/4/2011 Some of these devices can be remotely controlled. This has engendered concern about privacy and security issues, human error, and technical glitches with this technology.
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The K-Electric supports the NES operations to manage the plant and relays on energy provided by the nuclear power plant to feed through its circuits. The Pakistan Atomic Energy Commission, on the other hand, has the responsibility of running the overall operations of the nuclear power plant including computerized machinery, plant stimulators, and manufacturing of fuel bundles, producing fuel cycle, manufacturing tools, and employing of computers.
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Vibrotactile stimulators use pressure and the properties of the mechanoreceptors of the skin to initiate action potentials. There are advantages and disadvantages for both these stimulation systems. With the electrotactile stimulating systems a lot of factors affect the sensation triggered: stimulating voltage, current, waveform, electrode size, material, contact force, skin location, thickness and hydration. Electrotactile stimulation may involve the direct stimulation of the nerves (percutaneous), or through the skin (transcutaneous).
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The pathogenic Th17 cells are induced by IL-23 and IL-1β. IL-21, produced by Th17 cells themselves, has also been shown to initiate an alternative route for the activation of Th17 populations. Both interferon gamma (IFNγ) and IL-4, the main stimulators of Th1 and Th2 differentiation, respectively, have been shown to inhibit Th17 differentiation. Similar to Th17 cells the Treg17 development depended on the transcription factor Stat3.
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Toothbrushes with pointed rubber tips at the ends of the handles have been available for many years, and have more recently been replaced by a standalone tool called a gum stimulator designed to massage the gum line and the bases of the areas between the teeth. Such stimulators help to increase circulation to the gum line and to clear away bacteria which might not be removed by brushing and flossing alone.
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In the case of bladder control, contractions are controlled by the parasympathetic efferent pathways of the sacral section of the spine which renders lumbar stimulation ineffective. On the other hand, bladder control is closely associated with parasympathetic pathways on both the sacral and lumbar sections of the spine thus making sacro-lumbar anterior root stimulators a more viable option as it can deal with both sets of issues.
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An 18-inch latex double dildo A double penetration dildo or double dildo is a sex toy that allows for the simultaneous penetration of two bodily orifices at the same time. It is designed in the form of two penetrative stimulators (penis shaped or non-phallic) that come separately or fixed on the single shaft. Some of them include a vibrating motor that turns them into double penetration vibrators.
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Menthogen contains vasodilators; stimulators which act upon blood capillaries and hair bulbs (roots) which have the effect of increasing the blood supply (and therefore nourishment) to the scalp and its hair's bulbs. Phytohormones are also present. These natural plant substances that, at low concentration, are claimed to influence hair growth and are present in many of the other 300 000 available hair loss solution products available in the northern hemisphere.
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Harley Francis Flanagan (born March 8, 1967) is an American musician, writer and Brazilian jiu-jitsu practitioner. He is one of the founders of New York Hardcore band Cro-Mags. At age 12, Flanagan was the drummer for the New York Punk band the Stimulators. When he was nine years old, Flanagan published a book of poetry and drawings written when he was seven years old, with a foreword written by family friend Allen Ginsberg.
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Two powerful stimulators of uterine contraction, the diterpenes kaurenoic and grandiflorenic acids, were found in the leaves of Aspilia mossambicensis. This lends credence to the idea that wild chimpanzees consume leaves of Aspilia species because of their pharmacological properties and could shed light on female chimpanzees' consuming such leaves more frequently than do males. Substantial amounts of thiarubrines, antifungal and nematocidal dithianes, were found in roots of plants growing throughout chimpanzee habitats.
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The first nitric oxide (NO) independent, haem-dependent sGC stimulator, YC-1, a synthetic benzylindazole derivative, was described in 1978. The characterisation 20 years later demonstrated that as well as increasing sGC activity, YC-1 acted in synergy with NO to stimulate sGC. However, YC-1 was a relatively weak vasodilator and had side effects. Therefore, the search began for novel indazole compounds that were more potent and more specific sGC stimulators.
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While spinal cord injury is a broad and widely-encompassing term, root stimulators may be used for many instances of SCIs. For example, certain cases of spinal cord injuries may sever key nerves necessary to maintain bladder and bowel control. The severance is often the cause of Neurogenic Bowel Dysfunction. Similarly, spinal cord injuries can potentially cause a loss of motor control in lower limbs, such as with paraplegic and tetraplegic patients.
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Some research has shown that root stimulators may allow cycling to be feasible to those who suffer from paraplegia as a proof of concept. The devices may show promise in applications of more complex leg movement processes such as walking. At the very least, they offer a potential solution to delaying the issue of atrophy in paraplegics so that they might have an easier recovery in the case that better treatments come along.
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Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is synthesized only in neuropeptide Y (NPY)-containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. AgRP is co- expressed with NPY and acts to increase appetite and decrease metabolism and energy expenditure. It is one of the most potent and long-lasting of appetite stimulators.
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The two stimulation methods may result in significantly different results. Few studies have attempted to correlate chronaxie times with sensory perception, although understanding the neural elements that are involved in a subjective percept, such as tingling, has important physiological implications. The measurements were taken with different types of electrodes and with stimulators having unknown output impedances. The chronaxie values for human arm sensory nerves range from 0.35 to 1.17 ms, a ratio of 3.3.
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Fisher Wallace Laboratories, Inc., headquartered in New York City, markets the Fisher Wallace Stimulator, a cranial electrotherapy stimulation (CES) device.Allison Shelley for Medscape News. February 17, 2012 Electrical Stimulators Need High-Risk Rating, Says FDA PanelStaff, Sleep Review. June 11, 2014 FDA To Propose Approval/Reclassification of Cranial Electrotherapy Stimulation Devices for Insomnia The company was founded in 2007 by entrepreneur Charles Avery Fisher, son of electronics pioneer Avery Fisher, and Martin Wallace.
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The tape also featured their contemporaries the Stimulators, Bad Brains, the Undead, Heart Attack and Kraut. Even Worse also recorded an entire studio album in November 1981, which went unreleased until 2002. This most well-known version of the band broke up in early 1982, leaving Rabid to put together another totally different lineup including Tempkin, Waxman, journalist/DJ Sommer and Moore (the latter played guitar in the band during 1982-1983 while concurrently in Sonic Youth).
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IEEE Std 100-1996. [ed. Standards Coordinating Committee 10, Terms and Definitions; Jane Radatz, (chair)] In medicine, the term electrotherapy can apply to a variety of treatments, including the use of electrical devices such as deep brain stimulators for neurological disease. The term has also been applied specifically to the use of electric current to speed wound healing. Additionally, the term "electrotherapy" or "electromagnetic therapy" has also been applied to a range of alternative medical devices and treatments.
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One review of 400 cases found a success rate of only 9% for patients with stimulator placed over 15 years after onset of pain compared with nearly 85% for patients who received stimulators within two years of pain onset. Technical Difficulty – Variations in anatomy, whether congenital or acquired, may preclude successful placement in certain individuals. Imaging of the spine is necessary to guide selection of candidates for whom spine surgery is more appropriate than stimulator placement.
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The electrodes stimulate the area of the thalamus, specifically the part of the brain that controls movement and muscle function. It is notable that the presence of thalamic stimulators significantly changes ECG patterns, and prevents the use of MRI. It is sometimes regarded as a better alternative to pallidotomy or thalamotomy because it is non-permanent. For optimal installation, the patient is awake during the procedure, and talks to the surgeon to find the best placement.
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Pharmacological treatments are used to chemically treat sleep disturbances such as insomnia or excessive daytime sleepiness. The kinds of drugs used to treat sleep disorders include: anticonvulsants, anti-narcoleptics, anti-Parkinsonian drugs, benzodiazepines, non-benzodiazepine hypnotics, and opiates as well as the hormone melatonin and melatonin receptor stimulators. Anticonvulsants, opiates, and anti- Parkinsonian drugs are often used to treat restless legs syndrome. Furthermore, melatonin, benzodiazepines hypnotics, and non-benzodiazepine hypnotics may be used to treat insomnia.
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The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
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Dr. Flaherty is a joint associate professor of neurology and psychiatry at Harvard Medical School. She is a neurologist at Massachusetts General Hospital. She heads the MGH Neurology’s Brain Stimulator Unit, where “she uses deep brain stimulators to treat neurological disease and psychiatric disease. Her research focuses on how human brains represent their bodies, a factor that helps drive suffering in depression, Parkinson’s, and somatoform disorders.”Profile at ResearchCrossroads She writes in various genres, including “scientific papers, humorous essays, and picture books”.
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If there is an improvement, a permanent electrode can be implanted on the sacrum and connected to an stimulator which is in turn implanted in the lower abdominal wall or in the buttock. Implanted stimulators usually last 8 years. The patients who may benefit from SNS include those with intact anal sphincters and those with a history of unsuccessful anal repair. Complications of the surgery are rare, including pain and infection, which may require implant removal in 5% of cases.
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The stimulators are able to focus stimulation on the nerve roots of the spine and hypothetically improve the relief of neuropathic pain signals sent through the spinal cord. The study showed some promise as all subjects indicated some degree of pain relief. While this method may be more effective, it carries with it important risks that must be considered. Direct stimulation of the root risks greater neurological damage due to intra-operative spinal cord injury which in turn would yield further complications.
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Paraplegia is a condition in which a person loses the ability to control or perceive his or her lower limbs. Patients that have lost functional limb control due to spinal cord injuries often have further complications past the point of injury. Due to paralysis, paraplegics remain unable to exercise the leg muscles and leads to muscle atrophy. In such cases, lumbar anterior root stimulators may offer a minimal and temporary solution by allowing paraplegics some capacity to exercise the legs.
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His "unified theory" explains the prolonged effects of local anesthetic placed on the stellate ganglion resolving complex regional pain syndrome (CRPS). It also predicts the positive effect of SGB on estrogen depletion, hot flashes, PTSD and other conditions. Lipov has made numerous media appearances relating to his innovations in the treatment of chronic pain. Many have focused on state- of-the-art disk treatments, implantable neuro-stimulators for lower back pain and treatment of back and leg pain after surgery.
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KRS explored ultra-low power signal processing topologies to capture signals from large numbers of neurons in devices implanted in humans, e.g. deep brain stimulators. In 2010, while still a student at MIT, he co- founded Cerenova, Inc, a spinout from Massachusetts General Hospital Department of Neurosurgery, with noted functional neurosurgeon Emad Eskandar. Their work focused on novel applications of electrical neuromodulation for recovery and improvement of learning and cognition. In February 2017, KRS’ neurotechnology assets were acquired by Kernel for an undisclosed sum.
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Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels. Under normal physiological conditions angiogenesis is tightly regulated and is controlled by a balance of angiogenic stimulators and angiogenic inhibitors. Tumor growth is dependent upon angiogenesis and during tumor development a sustained production of angiogenic stimulatory factors is required along with a reduction in the quantity of angiogenic inhibitory factors tumor cells produce. The cleaved and latent form of antithrombin potently inhibit angiogenesis and tumor growth in animal models.
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Root stimulators are mounted onto the anterior roots of the spinal cord and electrically stimulate the neurons allowing them to propagate signals in their respective pathways and thus restore overall gastrointestinal function. Additional studies showed that a rhizotomy may also be performed on patients with the implant to reduce sensory reflexes which may otherwise inhibit the device's function. The procedure has been shown to both improve the device's function and reduce overall patient discomfort since the device is less likely to be rejected by the patient's body.
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She has also worked on batteries for neuro stimulators, drug delivery systems, pacemakers, and also industrial batteries for environments concerning high temperatures, vibrations, and need of reliability. In 2007, she joined academia at the University of Buffalo as the Greatbatch Professor of Advanced Power Sources. She is currently a Distinguished Professor at Stony Brook University in the departments of Chemistry, and Material Science and Engineering. She was selected as the 2013 recipient of the E.V. Murphree Award in Industrial and Engineering Chemistry, sponsored by Exxon Mobil.
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Patients who are candidates for stimulator placement should be screened for contraindications and comorbidities. The following should be considered prior to stimulator trial: Risk of Bleeding – Spinal cord stimulator trial and implant have been identified as procedures with high risk of serious intraspinal bleeding, which can cause permanent neurologic damage. Appropriate planning for discontinuation and reinstitution of anti-platelet and anticoagulant medications is necessary prior to placement of a stimulator. Psychological evaluation – Depression, anxiety, somatization, and hypochondriasis are associated with worse outcomes for Spinal Cord Stimulators.
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The difference was between communicating using two dimensional tactile images versus an 8-point code. Both Bliss and Geldard were reporting similar reading rates, but in the days before high accuracy optical character recognition, the Optacon approach was much more practical. These experiments determined the design parameters for Optacon's man-machine interface: a 24-by-6 array of tactile stimulators, vibrating between 250 and 300 Hz, and with the rows spaced at 1 mm and the columns spaced at 2 mm (See Fig. 2). Fig.
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The same results were found for certain inducers of apoptosis particularly stimulators of receptors in a class of lymphocytes (a type of white blood cell) called B-cells. Regulation of the de novo synthesis of ceramide by palmitate may have a key role in diabetes and the metabolic syndrome. Experimental evidence shows that there is substantial increase of ceramide levels upon adding palmitate. Ceramide accumulation activates PP2A and the subsequent dephosphorylation and inactivation of AKT, a crucial mediator in metabolic control and insulin signaling.
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Neurodevices are any devices used to monitor or regulate brain activity. Currently there are a few available for clinical use as a treatment for Parkinson's disease. The most common neurodevices are deep brain stimulators (DBS) that are used to give electrical stimulation to areas stricken by inactivity. Parkinson's disease is known to be caused by an inactivation of the basal ganglia (nuclei) and recently DBS has become the more preferred form of treatment for Parkinson's disease, although current research questions the efficiency of DBS for movement disorders.
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Even Worse was an American, New York City punk rock band, formed in 1980. Drummer Jack Rabid (who founded the music magazine The Big Takeover, also in 1980) was the only constant, as the band lineup changed numerous times over the course of the band's four-year existence. Other members included vocalists John Pouridas, John Berry, Garth Ripton, Rebecca "R.B." Korbet and Ken "Tantrum" Tempkin; guitarists Dave Stein, Robert Weeks, Thurston Moore and Steve Waxman; and bassists Nick Marden (later of the Stimulators), Eric Keil and Tim Sommer.
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Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53.
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Pyrethroids are direct stimulators of sodium channels in neuronal cells, inducing rapid depolarization and spastic paralysis leading to death. The effect is specific to the parasite since the drugs used are only slowly absorbed by the host and rapidly metabolized once absorbed. Cypermethrin (Excis, Betamax) and deltamethrin (Alphamax) are the two pyrethroids commonly used to control sea lice. Resistance to pyrethroids has been reported in Norway and appears to be due to a mutation leading to a structural change in the sodium channel which prevents pyrethroids from activating the channel.
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Flanagan is the father of two sons and is married to Laura Lee Flanagan, who is an attorney and serves as Flanagan's business manager and also works as general counsel and CCO to investment advisory firms. Flanagan is a black-belt in Brazilian jiu-jitsu and currently works as a professor for Renzo Gracie Academy in New York City. His students include the daughter of Anthony Bourdain, who coincidentally attended NYC Stimulators concerts in the early 1980s, and was a fan of the then preteen drummer. Flanagan has been a vegetarian since 1982.
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Changhong Electronics, a manufacturer of television sets, was reinvented from a plant producing electronic devices (including radars) for the military. The submarine manufacturer mentioned in the previous subsection switched to produce river cargo boats. These plants continued to be economic pillars and stimulators for the local economies. "Part of the achievement is that a batch of 'backbone' enterprises has evolved from the `Third Front' to develop more than 2,000 products including satellite and automobile parts and civilian aircraft," said Ji Dawei, a chief co-ordinator for the relocation drive.
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For example, vardenafil and tadalafil have demonstrated reduced adverse effects probably due to improved selectivity for PDE5. However, no highly selective PDE5 inhibitors are currently in development. Patients who take nitrates, alpha blockers or sGC stimulators within 24 hours of PDE5 inhibitor administration (or 48 hours for tadalafil) may experience symptomatic hypotension, so concurrent use is contraindicated. PDE5 inhibitors are also contraindicated in patients with hereditary eye conditions such as retinitis pigmentosa due to the small increased risk of nonarteritic ischaemic optic neuropathy in patients taking the medication.
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In TEDxGeorgiaTech: TEDx Neuromodulator devices can correct nervous system dysfunction related to Parkinson's disease, dystonia, tremor, Tourette's, chronic pain, OCD, severe depression, and eventually epilepsy. Neuromodulation is appealing as treatment for varying defects because it focuses in on treating highly specific regions of the brain only, contrasting that of systemic treatments that can have side effects on the body. Neuromodulator stimulators such as microelectrode arrays can stimulate and record brain function and with further improvements are meant to become adjustable and responsive delivery devices for drugs and other stimuli.
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Milnacipran (Ixel, Savella) and its stereoisomer levomilnacipran (Fetzima) are the only widely marketed SNRIs that inhibit serotonin and norepinephrine to similar degrees, both with ratios close to 1:1. Vilazodone (Viibryd) and vortioxetine (Trintellix) are SRIs that also act as modulators of serotonin receptors and are described as serotonin modulators and stimulators (SMS). Vilazodone is a 5-HT1A receptor partial agonist while vortioxetine is a 5-HT1A receptor agonist and 5-HT3 and 5-HT7 receptor antagonist. Litoxetine (SL 81-0385) and lubazodone (YM-992, YM-35995) are similar drugs that were never marketed.
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Butt plugs often have a flared base and are free of seams. Some anal stimulators are purposely ribbed or have a wave pattern in order to enhance pleasure and simulate intercourse. Stimulating the rectum with a rough-edged object or a finger (for the purposes of medically stimulating a bowel movement or other reasons) may lead to rectum wall tearing, especially if the fingernail is left untrimmed. Vegetables have rough edges and most have microorganisms on the surface, and thus could lead to infection if not sanitized before use.
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The Chashma Nuclear Power Plant site is owned by the Nuclear Regulatory Authority and is subjected to safeguards and monitoring provided under the International Atomic Energy Agency. The China-Pakistan Power Plant Corp. is an energy contractor that manages the on site operations of the nuclear power plant on behalf of Nuclear Regulatory Authority. The Pakistan Atomic Energy Commission has the responsibility of running the overall operations of the nuclear power plant including computerized machinery, plant stimulators, and manufacturing of fuel bundles, producing fuel cycle, manufacturing tools, and employing of computers.
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The Prostacyclin receptor , also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. IP binds to and mediates the biological actions of prostacyclin (also termed Prostaglandin I2, PGI2, or when used as a drug, epoprostenol). IP is encoded in humans by the PTGIR gene. While possessing many functions as defined in animal model studies, the major clinical relevancy of IP is as a powerful vasodilator: stimulators of IP are used to treat severe and even life- threatening diseases involving pathological vasoconstriction.
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Korte's four laws were first proposed in 1915 by Adolf Korte. The third law, particularly, describes how the increase in distance between two stimuli narrows the range of interstimulus intervals (ISI), which produce the apparent motion. It holds that there is a requirement for the proportional decrease in the frequency in which two stimulators are activated in alternation with the increase in ISI to ensure the quality of apparent motion. One identified violation of the Korte's law occurs if the shortest path between seen arm positions is not possible anatomically.
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Interventional procedures - typically used for chronic back pain - include epidural steroid injections, facet joint injections, neurolytic blocks, spinal cord stimulators and intrathecal drug delivery system implants. Pulsed radiofrequency, neuromodulation, direct introduction of medication and nerve ablation may be used to target either the tissue structures and organ/systems responsible for persistent nociception or the nociceptors from the structures implicated as the source of chronic pain. Radiofrequency treatment has been seen to improve pain in patients for facet joint low back pain. However, continuous radiofrequency is more effective in managing pain than pulsed radiofrequency.
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The patient is then triaged directly to the appropriate department of a hospital. The role of anesthesiologists in ensuring adequate pain relief for patients in the immediate postoperative period, as well as their expertise in regional anesthesia and nerve blocks, has led to the development of pain medicine as a subspecialty in its own right. The field comprises individualized strategies for all forms of analgesia, including pain management during childbirth, neuromodulatory technological methods such as transcutaneous electrical nerve stimulation or implanted spinal cord stimulators, and specialized pharmacological regimens.
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DBS is recommended for people who have PD with motor fluctuations and tremor inadequately controlled by medication, or to those who are intolerant to medication, as long as they do not have severe neuropsychiatric problems. Other, less common, surgical therapies involve intentional formation of lesions to suppress overactivity of specific subcortical areas. For example, pallidotomy involves surgical destruction of the globus pallidus to control dyskinesia. Four areas of the brain have been treated with neural stimulators in PD. These are the globus pallidus interna, thalamus, subthalamic nucleus and the pedunculopontine nucleus.
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H. C. Evans & Company of Chicago was once a leading manufacturer of casino equipment and supplies - both honest and crooked - in the United States. It was established in 1892 and collapsed in 1955. It was succeeded by Evans Park & Carnival Device Corporation, which was still in business in June 1961 but no longer trades, and by Evans Supply Company, which was trading in 1962 but no longer trades. In addition to casino equipment and supplies, the company manufactured and sold trade stimulators, pocket novelties, amusement park supplies, fair ground games and shooting galleries.
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Uli Lehmann, Bass Uli was born in the German wine-growing region Palatinate. He played in places like the Arabian Emirates and Hong Kong doing beertent music before moving to Munich and studying jazz bass. After that he played and recorded with Ali, Lisa Fitz, Ringsgwandl, Meilhammer & Schlenger, Steve Bigman Clayton and The Peter Schneider Band before joining the Stimulators. Hans Mühlegg, Congas, Bongos, Timbales & Percussion Hans was born and raised near Murnau in Bavaria. It was there that he started to play percussion and formed a band with his school mates called “Fretless”.
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PDE5 inhibitors are contraindicated within 24 hours (or 48 hours with tadalafil) of taking alpha-blockers, soluble guanylate cyclase stimulators, or nitrate medications such as isosorbide mononitrate or isosorbide dinitrate. Concurrent use of these medications can lead to life-threatening low blood pressure. PDE5 inhibitors are also contraindicated in patients with previous nonarteritic anterior ischaemic optic neuropathy and hereditary eye diseases. Despite initial concerns of adverse cardiovascular events in patients prescribed PDE5 inhibitors, several long-term studies have established the safety of the drugs in both healthy patients and patients with cardiovascular risk factors.
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The Cro-Mags are an American hardcore punk band from New York City, United States. The band, which has a strong cult following, has released five studio albums, their first two considered the most influential. With a Hare Krishna background, they were among the first bands to fuse hardcore punk with thrash metal and were associated with the birth of a tougher attitude within the hardcore scene in the late 1980s, related to the world of martial arts. Harley Flanagan (former drummer for the Stimulators) and John Joseph are practitioners of Brazilian jiu-jitsu and boxing respectively.
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A craniotomy is a surgical operation in which a bone flap is temporarily removed from the skull to access the brain. Craniotomies are often critical operations, performed on patients who are suffering from brain lesions or traumatic brain injury (TBI), and can also allow doctors to surgically implant deep brain stimulators for the treatment of Parkinson's disease, epilepsy, and cerebellar tremor. The procedure is also widely used in neuroscience for extracellular recording, brain imaging, and for neurological manipulations such as electrical stimulation and chemical titration. The procedures are used for accessing brain tissue that must be removed, as well.
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The Stimulators played regularly at city rock venues, including CBGB, Irving Plaza, Paradise Garage, Tier 3, Danceteria, A7, and Max's Kansas City, and also toured both nationally, and in Ireland. They shared bills with bands like Madness, Stiff Little Fingers, the Cramps, Bad Brains, James Chance & the Contortions, Teenage Jesus & the Jerks, the B-52's, Richard Hell, Pure Hell, the Blessed, the Mad, Suicide, The Rattlers, The Necros, and The Circle Jerks. In 1980 they recorded the single "loud, fast, rules!", and in 1982 released a live album of the same name, recorded live in Raleigh, North Carolina.
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The phrase "loud, fast, rules!" came from bassist Nick Marden (who like Flannagan, had been around rock music from early childhood, his aunt Joan Baez having taken him to Monterey Pop when he was 8). Marden wrote the phrase on the back of his punk leather jacket, surrounded by band names, and when noticed by his bandmates, was used as a title for a song Mercedes and Mack had already written. The title became something of a punk rock catchphrase in its time. Patrick Mack died in 1983 of complications associated with AIDS, ending the Stimulators' run.
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Maytag Toy Racer The Maytag Toy Racer was a series of small one-passenger automobiles built by the Maytag Company between October 11, 1934 and December 1, 1941 for promotional purposes. The toy racer was powered by Maytag Model 92 one-cylinder or, later, two-cylinder air-cooled Multi-Motor engines."Maytag Toy Racers boost Dealers' Sales. Small Autos Prove Good 'Stimulators'. Boys and Girls Prove Ardent Canvassers When Automobiles are Offered as Premiums for Work," Maytag News, 8 (10)(November 1934): 2-3. Previously in 1932 the Winston Corporation of Joliet, Illinois made a toy racer powered by the Maytag Multi- Motor.
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There are several implantable interfaces that are currently available for consumer use including deep brain stimulators, cochlear implants, and cardiac pacemakers. Deep brain stimulation (DBS) has been effective at treating movement disorders such as Parkinson's disease, and cochlear implants have helped many to improve their hearing by assisting stimulation of the auditory nerve. Because of their remarkable potential, MEAs are a prominent area of neuroscience research. Research suggests that MEAs may provide insight into processes such as memory formation and perception and may also hold therapeutic value for conditions such as epilepsy, depression, and obsessive-compulsive disorder .
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Transcutaneous electrical nerve stimulation (TENS or TNS) is the use of electric current produced by a device to stimulate the nerves for therapeutic purposes. TENS, by definition, covers the complete range of transcutaneously applied currents used for nerve excitation although the term is often used with a more restrictive intent, namely to describe the kind of pulses produced by portable stimulators used to reduce pain.Robertson, The unit is usually connected to the skin using two or more electrodes which are typically conductive gel pads. A typical battery-operated TENS unit is able to modulate pulse width, frequency and intensity.
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Drop foot is a common symptom in hemiplegia, characterized by a lack of dorsiflexion during the swing phase of gait, resulting in short, shuffling strides. It has been shown that FES can be used to effectively compensate for the drop foot during the swing phase of the gait. At the moment just before the heel off phase of gait occurs, the stimulator delivers a stimulus to the common peroneal nerve, which results in contraction of the muscles responsible for dorsiflexion. There are currently a number of drop foot stimulators that use surface and implanted FES technologies.
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Drop foot stimulators have been used successfully with various patient populations, such as stroke, spinal cord injury and multiple sclerosis. The term "orthotic effect" can be used to describe the immediate improvement in function observed when the individual switches on their FES device compared to unassisted walking. This improvement disappears as soon as the person switches off their FES device. In contrast, a "training" or "therapeutic effect" is used to describe a long term improvement or restoration of function following a period of using the device which is still present even when the device is switched off.
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Given the inconclusiveness of potential benefits and risks of testosterone and DHEA supplementation, longer-term, randomized studies are warranted for women and girls with POI. Ovarian tissue cryopreservation can be performed on prepubertal girls at risk for premature ovarian failure, and this procedure is as feasible and safe as comparable operative procedures in children. In 2013, Kawamura in Japan and his collaborators at Stanford University published treatment of infertility of POI patients by fragmenting ovaries followed by in vitro treatment of ovarian fragments with Akt stimulators and autografting. They successfully promoted follicle growth, retrieved mature oocytes, and performed in vitro fertilization.
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The KLOV's entries are heavily weighted for classic arcade games: that is, games released during the Golden Age of Arcade Games. Most arcade games have an entry, though entries for newer games tend to be spotty. The more popular a game was, the more extensive the entry is likely to be. The encyclopedia database is actually a subset of that on the International Arcade Museum's web site, which expands on the videogame entries with an additional 9,000 entries on other types of coin-operated machines such as pinball machines, slot machines, vending, trade stimulators, and scales.
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The basic principle behind a diaphragm pacing device (the U.S. Food and Drug Administration identifies the device as a "diaphragmatic/phrenic nerve stimulator") involves passing an electric current through electrodes that are attached internally. The diaphragm contracts, expanding the chest cavity, causing air to be sucked into the lungs (inspiration). When not stimulated, the diaphragm relaxes and air moves out of the lungs (expiration). According to the United States Medicare system, phrenic nerve stimulators are indicated for "selected patients with partial or complete respiratory insufficiency" and "can be effective only if the patient has an intact phrenic nerve and diaphragm".
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RasGEF domain is domain found in the CDC25 family of guanine nucleotide exchange factors for Ras-like small GTPases. Ras proteins are membrane- associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP. The latter proteins are known as guanine-nucleotide dissociation stimulators (GDSs) (or also as guanine-nucleotide releasing (or exchange) factors (GRFs)).
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Attempts at addressing intractable pain syndromes with DBS were met with more success, but again hampered by the quality of technology. A number of physicians who hoped to address hitherto intractable problems sought development of more specialized equipment; for instance, in the 1960s, Wall's colleague Bill Sweet recruited engineer Roger Avery to make an implantable peripheral nerve stimulator. Avery started the Avery Company, which made a number of implantable stimulators. Shortly before his retirement in 1983, he submitted data requested by the FDA, which had begun to regulate medical devices following a 1977 meeting on the topic, regarding DBS for chronic pain.
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The main advantage of FUS is that, unlike most brain-stimulation techniques, it is non-invasive. Whenever the human looks at a specific pattern (strobe light flicker) on a computer screen, the BCI communicates a command to the rat's CBI, which causes ultrasound to be beamed into the region of the rat's motor cortex responsible for tail movement. The researchers report that the human BCI has an accuracy of 94%, and that it generally takes around 1.5 s from the human looking at the screen to movement of the rat's tail. Another system that non-invasively controls rats uses ultrasonic, epidermal and LED photic stimulators on the back.
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In his review of the Stimulators' only album, a reviewer from AllMusic noted that the music "exist(s) in the gray area between two eras of punk rock... the latter days of New York Punk's first wave (...and) the more manic and aggressive hardcore style". It was the reviewer's opinion that Patrick Mack's vocals were better suited for the former. He also noted that Denise Mercedes had "guitar heroine" ambition, playing flashier solos than are typical in punk rock. He acknowledged the band's reputation as "one of the better bands on the early-'80s New York scene", but lamented that, in his opinion, the recording did not capture this adequately.
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Evidence is insufficient to support DBS as a therapeutic modality for depression; however, the procedure may be an effective treatment modality in the future. In fact, beneficial results have been documented in the neurosurgical literature, including a few instances in which people who were deeply depressed were provided with portable stimulators for self treatment. A systematic review of DBS for TRD and OCD identified 23 cases, nine for OCD, seven for TRD, and one for both. "[A]bout half the patients did show dramatic improvement" and adverse events were "generally trivial" given the younger age of the psychiatric population relative to the age of people with movement disorders.
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The Medical Device Radiocommunications Service (MedRadio) is a specification and communication spectrum created for and set aside by the U.S. Federal Communications Commission (FCC) for the communication needs of diagnostic and therapeutic medical implants and body-worn medical devices. Devices operating on MedRadio include cardiac pacemakers, defibrillators, neuromuscular stimulators, and drug delivery systems. , communications spectrum for these and other similar devices is set aside at various points in the 400 MHz frequency band, as well as the 2360-2400 MHz band, though specifically for medical body area network (MBAN) devices. The specification supersedes and incorporates a previous specification called the Medical Implant Communication Service (MICS).
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Anti-3rd party veto cells were developed to address the need for large numbers of donor veto cells to infuse along with the graft, as a tool for the induction of donor-tolerance. These cells are produced from naive donor CD8+ cells because CD8+ cells have the best veto activity. By expanding naïve CD8 T cells against 3rd-party stimulators under cytokine deprivation, clones that are reactive against the host are eliminated due to lack of nutrients and signaling. The expression of a central memory T cell (Tcm) phenotype helps these host non- reactive veto cells reach the lymph nodes where they eradicate anti-donor T cell precursors.
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Heath, in the 1950s, stimulated subcortical areas and made detailed observations of behavioral changes. A new understanding of pain perception was ushered in in 1965, with the Gate Theory of Wall and Melzack. Although now considered oversimplified, the theory held that pain transmissions from small nerve fibers can be overridden, or the gate "closed", by competing transmissions along the wider touch nerve fibers. Building on that concept, in 1967, the first dorsal column stimulator for pain control was demonstrated by Dr. Norm Shealy at Western Reserve Medical School, using a design adapted by Tom Mortimer, a graduate student at Case Institute of Technology, from cardiac nerve stimulators by Medtronic, Inc.
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Int J Obes 29:682–688 Hot peppers have been reported to induce thermogenesis at the cellular level.Yoshioka, M., Lim, K., Kikuzato, S., Kiyonaga, A., Tanaka H. and Shindo M. (1995) Effects of red-pepper diet on the energy metabolism in men, J Nutr Sci Vitaminol. 41:647–656Eldershaw T.P., Colquhoun E.Q., Bennett K.L., Dora K.A. and Clark M.G. (1994) Resiniferatoxin and piperine: capsaicin- like stimulators of oxygen uptake in the perfused rat hindlimb, Life Sci 55:389–397 As well, capsaicin induces satiety as a result of oral and gastro- intestinal contribution. Lower energy and fat intake were observed under short-term conditions; however, the effect of the spice was reduced over prolonged exposure.
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He had a book of poetry entitled Stories & Illustrations by Harley (Charlatan Press), with a foreword written by family friend Allen Ginsberg, published when he was nine. His mother was acquainted with members of the Velvet Underground/New York Dolls-era New York Rock scene, and Harley had frequently accompanied his aunt Denise to CBGB and Max's Kansas City. He proved to be an energetic and capable drummer. The Stimulators, whose eclectic original lineup, now complete, featured two women, a homosexual man, and a child, began to attract a following from young city music fans that were still drawn to the initial spirit of punk rock from which the original CBGB bands had largely distanced themselves.
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Serotonin modulator and stimulators (SMSs), sometimes referred to more simply as "serotonin modulators", are a type of drug with a multimodal action specific to the serotonin neurotransmitter system. To be precise, SMSs simultaneously modulate one or more serotonin receptors and inhibit the reuptake of serotonin. The term was coined in reference to the mechanism of action of the serotonergic antidepressant vortioxetine, which acts as a serotonin reuptake inhibitor (SRI), partial agonist of the 5-HT1A receptor, and antagonist of the 5-HT3 and 5-HT7 receptors. However, it can also technically be applied to vilazodone, which is an antidepressant as well and acts as an SRI and 5-HT1A receptor partial agonist.
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A diagram of a hippocampal prosthesis Neural prostheses are a series of devices that can substitute a motor, sensory or cognitive modality that might have been damaged as a result of an injury or a disease. Neurostimulators, including deep brain stimulators, send electrical impulses to the brain in order to treat neurological and movement disorders, including Parkinson's disease, epilepsy, treatment resistant depression, and other conditions such as urinary incontinence. Rather than replacing existing neural networks to restore function, these devices often serve by disrupting the output of existing malfunctioning nerve centers to eliminate symptoms. Scientists in 2013 created a mini brain that developed key neurological components until the early gestational stages of fetal maturation.
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The three cysteinyl leukotrienes, LTC4, LTD4, and LTE4, are potent bronchoconstrictors, increasers of vascular permeability in postcapillary venules, and stimulators of mucus secretion that are released from the lung tissue of asthmatic subjects exposed to specific allergens. They play a pathophysiological role in diverse types of immediate hypersensitivity reactions. Drugs that block their activation of the CYSLTR1 receptor viz., montelukast, zafirlukast, and pranlukast, are used clinically as maintenance treatment for allergen-induced asthma and rhinitis; nonsteroidal anti- inflammatory drug-induced asthma and rhinitis (see Aspirin-induced asthma); exercise- and cold-air induced asthma (see Exercise-induced bronchoconstriction); and childhood sleep apnea due to adenotonsillar hypertrophy (see Acquired non-inflammatory myopathy#Diet and Trauma Induced Myopathy).
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In the late 1970s Fury moved to Manhattan and built a rehearsal studio on 17th Street named Roach, less than two blocks from punk club Max's Kansas City. The studio was used by punk pioneers The Voidoids, James Chance, The Stimulators, and the Bush Tetras. Inspired by Sam Phillips' Sun Studio in Memphis, Fury built a second studio on 18 Spring Street four blocks from punk club CBGB, where Sonic Youth rehearsed. Fury recorded New York hardcore, punk, straight- edge and post-hardcore bands at the Spring Street studio including Agnostic Front, Sick of It All, Underdog, Youth of Today, Gorilla Biscuits, Madball, Civ, Warzone, Helmet, Into Another, and Quicksand, and Fury proposed the CBGB Hardcore Matinee to Carol Costa and Hilly Kristal.
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Growth hormone-releasing peptide 6 (GHRP-6) (developmental code name SKF-110679), also known as growth hormone-releasing hexapeptide, is one of several synthetic met-enkephalin analogues that include unnatural D-amino acids, were developed for their growth hormone-releasing activity and are called growth hormone secretagogues. They lack opioid activity but are potent stimulators of growth hormone (GH) release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through activation of a completely different receptor. This receptor was originally called the growth hormone secretagogue receptor (GHSR), but due to subsequent discoveries, the hormone ghrelin is now considered the receptor's natural endogenous ligand, and it has been renamed as the ghrelin receptor.
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Laboratory studies indicate that these 3 cytokines acting individually or in synergy are potent stimulators of the JAK1/STAT3 signaling pathway in iCD3+IEL and thereby promote these cells survival (by blocking apoptosis) and proliferation. The small intestinal lesions also contain a tumor necrosis factor which stimulates iCD3+IEL survival and proliferation but does so by activating NF-κB, MAPK, and/or c-Jun N-terminal kinases rather than JAK1/STAT3 signaling pathway. These data suggest that: a) Type II RCD is a low grade lymphoma; 2) the intense inflammation in Type II RCD, perhaps amplified by the cited cytokines, promotes the proliferation, survival, genome instability, and consequential genetic abnormalities in IEL; and 3) one or more of these factors cause the transformation of Type II RD to EATL.
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This theory postulates that activation of large diameter, myelinated primary afferent fibers suppresses the response of dorsal horn neurons to input from small, unmyelinated primary afferents. A simple SCS system consists of three different parts. First, microelectrodes are implanted in the epidural space to deliver stimulation pulses to the tissue. Second, an electrical pulse generator implanted in the lower abdominal area or gluteal region while is connected to the electrodes via wires, and third a remote control to adjust the stimulus parameters such as pulse width and pulse rate in the PG. Improvements have been made in both the clinical aspects of SCS such as transition from subdural placement of contacts to epidural placement, which reduces the risk and morbidity of SCS implantation, and also technical aspects of SCS such as improving percutaneous leads, and fully implantable multi-channel stimulators.
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It became an international success and today is one of the leading examples of avant-garde film and video in Poland. Pawłowski's later work included Naturally Shaped Forms (1963), reliefs produced by the pressure of metal tape on the reverse of the picture, Mannequins (1968), sculptures produced from a liquid medium setting in sacks tied with a cord into casts shaped by the force of inertia of the medium, Stimulators of Inadequate Impressions (1967), sculptures enclosed in containers whose shapes may only be determined by touch, and Conversations with an Idiot (1977–1980), an attempt to design the 'ideal' chair with the aid of a computer. Pawłowski was furthermore a member of the Association of Polish Visual Artists and the Association of Polish Artistic Photographers, as well as a participant of the International Council of Societies of Industrial Design (ICSID).
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A gonadotropin-releasing hormone agonist (GnRH agonist) is a GnRH modulator that activates the GnRH receptor resulting in increased secretion of FSH and LH. Initially it was thought that GnRH agonists could be used as potent and prolonged stimulators of pituitary gonadotropin release, but it was soon recognized that GnRH agonists, after their initial stimulating action – termed a "flare" effect – eventually caused a paradoxical and sustained drop in gonadotropin secretion. This second effect was termed "downregulation" and can be observed after about 10 days. While this phase is reversible upon stopping the medication, it can be maintained when GnRH agonists use is continued for a long time. GnRH agonists can also be administered in a pulsatile manner through the use of a pump to produce a long-term stimulation of gonadotropin secretion, for instance to induce puberty.
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They played shows in New York City clubs including: A7, CBGB, Rock Lounge, Mudd Club, Club 57, Rock Hotel and 2+2; and played with Bad Brains, The Stimulators, Dead Kennedys, Ramones, P.I.L., Hüsker Dü, the Mob, the Necros, Adrenalin O.D. and the Beastie Boys. On Friday, November 13, 1982, The Young and the Useless opened for the Beastie Boys at a concert produced by Philip Pucci, in honor of his birthday for the purposes of his short concert film of the Beastie Boys, Beastie. Pucci held the concert in Bard College's Preston Drama Dance Department Theatre. This performance marked both The Young and the Useless' and the Beastie Boys' first on screen appearance in a published motion picture, although the segment including The Young and the Useless was not included in the film's final edit.
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A Chi site or Chi sequence is a short stretch of DNA in the genome of a bacterium near which homologous recombination is more likely to occur than on average across the genome. Chi sites serve as stimulators of DNA double-strand break repair in bacteria, which can arise from radiation or chemical treatments, or result from replication fork breakage during DNA replication. The sequence of the Chi site is unique to each group of closely related organisms; in E. coli and other enteric bacteria, such as Salmonella, the core sequence is 5'-GCTGGTGG-3' plus important nucleotides about 4 to 7 nucleotides to the 3' side of the core sequence. The existence of Chi sites was originally discovered in the genome of bacteriophage lambda, a virus that infects E. coli, but is now known to occur about 1000 times in the E. coli genome.
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They are noninvasive, easy to apply, and generally inexpensive. Until recently the common belief in the FES field has been that due to the electrode-skin contact impedance, skin and tissue impedance, and current dispersion during stimulation, much higher- intensity pulses are required to stimulate nerves using surface stimulation electrodes as compared to the subcutaneous electrodes. (This statement is correct for all commercially available stimulators except MyndMove stimulator, which has implemented a new stimulation pulse that allows the stimulator to generate muscle contractions without causing discomfort during stimulation, which is a common problem with commercially available transcutaneous electrical stimulation systems.) A major limitation of the transcutaneous electrical stimulation is that some nerves, for example those innervating the hip flexors, are too profound to be stimulated using surface electrodes. This limitation can be partly addressed by using arrays of electrodes, which can use several electrical contacts to increase selectivity.
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Max's Kansas City reopened in 1975 under the ownership of Tommy Dean Mills, who initially thought he would make it a disco. Peter Crowley, who had been booking the same early punk bands that played at CBGB and Mothers, a gay bar on West 23rd Street, was hired to book bands at Max's. Under Crowley's guidance the club became one of the birthplaces of punk, regularly featuring bands including Cherry Vanilla, Wayne County & the Electric Chairs, Ruby and the Rednecks, The Offs, The Fast, Suicide (who all appeared on the compilation album "1976 Max's Kansas City"), the New York Dolls, Patti Smith Group, the Ramones, the Mumps, the Heartbreakers, Television, Blondie, Talking Heads, Sniper, the Dictators, the Cramps, Mink DeVille, Misfits, Little Annie, the Fleshtones, the B-52's, the Stimulators, the Bongos and Klaus Nomi, as well as out-of-town bands such as the Runaways and the Damned. After the breakup of the Sex Pistols, Sid Vicious played all of his US solo gigs there.
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