But if I'm going to produce something that has creative depth, sonically, somatically, I just don't have a choice about what happens.
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Its brazen violence and harsh mix felt even more somatically cathartic, juxtaposed with the day's earlier Jason Derulo and Taylor Swift tracks.
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And so my position on that is that we use CRISPR to edit people that are alive (somatically) and not edit the germline in embryos.
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" Machado writes about enormity somatically: the gut, the rush of blood, the fluids and the feelings, the commotion in our chests — "the simultaneous leap of excitement yanked back by a leash of panic.
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This is both somatically challenging and disorienting (and even painful, if the viewer happens, hypothetically, to be slightly myopic and astigmatic and also refuses to wear glasses), made all the more so by the slight backward tilt of the piece.
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The second is the result of internal deletions in functional MuDR elements, which can be produced both somatically and germinally.
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Each allele is germinally and somatically stable in the absence of Ac but is unstable in the presence of Ac, typical of Ds-containing alleles.
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Methylation of the cytosine of CpG dinucleotides is a somatically heritable and conserved regulatory mark that is generally associated with transcriptional repression. CpG islands keep their overall un-methylated state (or methylated state) extremely stably through multiple cell generations.
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In cancers, loss of expression of genes occurs about 10 times more frequently by transcription silencing (caused by somatically heritable promoter hypermethylation of CpG islands) than by mutations. As Vogelstein et al. point out, in a colorectal cancer there are usually about 3 to 6 driver mutations and 33 to 66 hitchhiker or passenger mutations. In contrast, in colon tumors compared to adjacent normal-appearing colonic mucosa, there are about 600 to 800 somatically heritable heavily methylated CpG islands in promoters of genes in the tumors while these CpG islands are not methylated in the adjacent mucosa.
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Acedia depicted as a sleeping man and a bat in the Goat Church in Sopron, Hungary. Acedia is indicated by a range of signs. These signs (or symptoms) are typically divided into two basic categories: somatic and psychological. Acedia frequently presents signs somatically.
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Theories on emotion have focused on perception, subjective experience, and appraisal. Predominant theories of emotion and emotion perception include what type of emotion is perceived, how emotion is perceived somatically, and at what stage of an event emotion is perceived and translated into subjective, physical experience.
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The COSMIC database was designed to collect and display information on somatic mutations in cancer. It was launched in 2004, with data from just four genes, HRAS, KRAS2, NRAS and BRAF. These four genes are known to be somatically mutated in cancer. Since its creation, the database has expanded rapidly.
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Cerebellar Purkinje neurons have been proposed to have two distinct bursting modes: dendritically driven, by dendritic spikes, and somatically driven, wherein the persistent current is the burst initiator and the SK current is the burst terminator. Purkinje neurons may utilise these bursting forms in information coding to the deep cerebellar nuclei.
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Among the neurons in the human brain, somatically derived copy-number variations are frequent. Copy-number variations show wide variability (9 to 100% of brain neurons in different studies). Most alterations are between 2 and 10 Mb in size with deletions far outnumbering amplifications. Copy number variations appear to be higher in brain cells than in other cell types.
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Somatically, they form a morphologically similar mycelial wave front that continues to grow and explore. The significant difference is that each septated unit is binucleate, containing two unfused nuclei, i.e. one from each parent that eventually undergoes karyogamy and meiosis to complete the sexual cycle. Also the term "anastomosing" is used for mushroom gills which interlink and separate to form a network.
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Pigment cells that exhibit fluorescence are called fluorescent chromatophores, and function somatically similar to regular chromatophores. These cells are dendritic, and contain pigments called fluorosomes. These pigments contain fluorescent proteins which are activated by K+ (potassium) ions, and it is their movement, aggregation, and dispersion within the fluorescent chromatophore that cause directed fluorescence patterning. Fluorescent cells are innervated the same as other chromatophores, like melanophores, pigment cells that contain melanin.
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Some types of fear conditioning (e.g. contextual and trace) also involve the hippocampus, an area of the brain believed to receive affective impulses from the amygdala and to integrate those impulses with previously existing information to make it meaningful. Some theoretical accounts of traumatic experiences suggest that amygdala-based fear bypasses the hippocampus during intense stress and can be stored somatically or as images that can return as physical symptoms or flashbacks without cognitive meaning.
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COSMIC is an online database of somatically acquired mutations found in human cancer. Somatic mutations are those that occur in non-germline cells that are not inherited by children. COSMIC, an acronym of Catalogue Of Somatic Mutations In Cancer, curates data from papers in the scientific literature and large scale experimental screens from the Cancer Genome Project at the Sanger Institute. The database is freely available to academic researchers and commercially licensed to others.
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Other factors include the loss of methylation, increasing gene expression heterogeneity correlating to genomic abnormalities and telomere shortening. It is uncertain if transcription-based DNA repair takes part in the maintaining of somatic mutations in aging tissues. In some cells, the somatically acquired alterations can be reversed back to wild type alleles by reversion mosaicism. This can be due to endogenous mechanism such as homologous recombination, codon substitution, second-site suppressor mutations, DNA slippage and mobile elements.
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His clinical work as a musculo-skeletal physician includes osteopathy and acupuncture, and by somatically-oriented psychotherapeutic methods devised by Peter Levine, as well as exploration of working with the relaxation response, yoga, and meditation. A particular clinical interest is in dysregulatory syndromes where persistent pain and/or fatigue commonly overlap with trauma and breathing pattern disorders. His research and development interests include the role of non-pharmaceutical treatments in mainstream medicine, and self-care – particularly in long term conditions.
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On the other hand, a mutation may occur in a somatic cell of an organism. Such mutations will be present in all descendants of this cell within the same organism. The accumulation of certain mutations over generations of somatic cells is part of cause of malignant transformation, from normal cell to cancer cell. Cells with heterozygous loss-of-function mutations (one good copy of gene and one mutated copy) may function normally with the unmutated copy until the good copy has been spontaneously somatically mutated.
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Douglas Robinson first began developing a somatic theory of language for a keynote presentation at the 9th American Imagery Conference in Los Angeles, October, 1985, based on Ahkter Ahsen's theory of somatic response to images as the basis for therapeutic transformations; in contradistinction to Ahsen's model, which rejected Freud's "talking cure" on the grounds that words do not awaken somatic responses, Robinson argued that there is a very powerful somatics of language. He later incorporated this notion into The Translator's Turn (1991), drawing on the (passing) somatic theories of William James, Ludwig Wittgenstein, and Kenneth Burke in order to argue that somatic response may be "idiosomatic" (somatically idiosyncratic) but typically is "ideosomatic" (somatically ideological, or shaped and guided by society), and that the ideosomatics of language explains how language remains stable enough for communication to be possible. This work preceded the Damasio group's first scientific publication on the somatic-marker hypothesis in 1991,Damasio, Antonio R., Daniel Tranel, and Hannah Damasio. (1991). "Somatic Markers and the Guidance of Behaviour: Theory and Preliminary Testing." In H.S. Levin, H.M. Eisenberg and A.L. Benton (eds.), Frontal lobe function and dysfunction, 217-229.
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The RAD54B gene is somatically mutated or deleted in numerous types of cancer including colorectal cancer (~3.3%), breast cancer (~3.4%), and lung cancer (~2.6%). In North America, these three cancers alone account for about 20,500 individuals diagnosed annually with RAD54B defective cancer. In a pre-clinical study, colon cancer cells defective in RAD54B were determined to be selectively killed by inhibitors of the DNA repair protein PARP1. Inhibitors of PARP1 likely impede alternative DNA repair responses that might otherwise compensate for loss of the RAD54B pathway in cancer cells.
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Despite its indisputable role in scientific discoveries and numerous treatment strategies, the hybridoma technology presents researchers with some obstacles such as ethical issues, potential to lose expression of the target protein or lengthy production and most importantly the development of HAMA in patients as mentioned previously. Therefore, different methods need to complement or even partially replace the hybridoma. Hybridomas are an essential part of the recombinant antibody generation even today as they are still used to produce the monoclonal antibodies, from which the Fab fragments, scFv or somatically fused antibodies create a bispecific antibody.
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Bizzaria, an unusual graft-chimera. Due to the sterility of many of the genetic hybrids as well as disease- or temperature-sensitivity of some Citrus trees, domesticated citrus cultivars are usually propagated via grafting to the rootstock of other, often hardier though less palatable citrus or close relatives. As a result, graft hybrids, also called graft-chimaeras, can occur in Citrus. After grafting, the cells from the scion and rootstock are not somatically fused, but rather the cells of the two intermix at the graft site, and can produce shoots from the same tree that bear different fruit.
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If a mutation occur in a somatic cell of an organism, it will be present in all descendants of this cell within the same organism. The accumulation of certain mutations over generations of somatic cells is part of the process of malignant transformation, from normal cell to cancer cell. Cells with heterozygous loss-of-function mutations (one good copy of a gene and one mutated copy) may function normally with the unmutated copy until the good copy has been spontaneously somatically mutated. This kind of mutation happens often in living organisms, but it is difficult to measure the rate.
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The cost of a cesarean section, the recommended mode of delivery for brain dead pregnant women, is roughly $4,500 for physicians' fees alone, according to the Healthcare Bluebook. Depending upon how many weeks a neonate is premature, he or she could spend anywhere between two and four months in the NICU. NICU costs generally run more than $3,500 per day. The most recent peer-reviewed investigation to note the overall cost of care for a viable child delivered from a somatically supported brain dead mother focused on the case of a child delivered via cesarean section in California on the 63rd hospital day at 31 weeks gestation, to a mother who was brain dead at 22 weeks gestation in 1983.
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Yet again, the Kikuyu campaign was utterly successful. The lessons learnt from the Kikuyu campaign gave impetus to an effective regional strategy. One of the key elements of the program was the national school milk program which provided daily provision of milk to kindergarten through preparatory school children during morning and afternoon recess sessions; moreover, educators were mandated to somatically check pupils for health and hygiene during physical education (PE) periods; further, schools were duty-bound to maintain up-to-date requisite immunization records. Indeed, this was one of the constituents of a multi-part dynamic public health strategy—which had been explicitly adapted by the East African Commission—toward health wellness; thus, socioeconomic, sociocultural, and socioecological progressions in the region.
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KCNQ1OT1 is a paternally expressed allele and KCNQ1 is a maternally expressed allele. KCNQ1OT1 is a nuclear, 91 kb transcript, found in close proximity to the nucleolus in certain cell types. It interacts with chromatin, the histone methyltransferase G9a (responsible for the mono- and dimethylation of histone 3 lysine 9, H3K9), and the Polycomb Repressive Complex 2, PRC2, (responsible for the trimethylation of H3K27). It plays an important role in the transcriptional silencing of the KCNQ1 locus by regulating histone methylation. An 890 bp region at the 5′ end of KCNQ1OT1 acts as a silencing domain. This region regulates CpG methylation levels of somatically acquired differentially methylated regions (DMRs), mediates the interaction of KCNQ1OT1 with chromatin and with DNA (cytosine-5)-methyltransferase 1 (DNMT1), but does not affect the interactions of histone methyltransferases with KCNQ1OT1.
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