While not especially sleep inducing, his videos are extremely relaxing.
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So I set about making my space as sleep-inducing as possible.
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On the other hand, melatonin is a hormone known for its sleep-inducing properties.
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I dodged to the left, now surrounded on two sides by the sleep-inducing smoke.
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Melatonin is the body's natural sleep-inducing hormone and is available in pharmacies without a prescription.
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Here are our sleep-inducing snack suggestions to add to your cart next time you're grocery shopping.
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Or, they can listen to FM radio or any combination of the 10 sleep-inducing ambient sounds.
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The toxicology reports found five drugs in his system, including two powerful painkillers and sleep-inducing medication.
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I have a tea for every mood and ailment from sleep-inducing tea to sore-throat-soothing tea.
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Like the first meal, it was fantastic and flavorful, but definitely more of a sleep-inducing comfort food.
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Cheddar cheese has even more than turkey, yet cheddar is never pointed out as a sleep-inducing food.
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An indica usually offers more of a relaxing, sleep-inducing sensation, so those are "your classic insomnia strains," says Barcott.
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Caffeine is a powerful stimulant that interferes with sleep by increasing adrenaline production and blocking sleep-inducing chemicals in the brain.
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Combine that with intriguing but relatively mundane explorations of design, and you've got the perfect recipe for a sleep-inducing podcast.
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The spa on Celebrity Cruises' new ship, the Celebrity Edge, has a sleep-inducing treatment called the Ocean Spa Wave Massage.
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While these heavy ingredients sound more like a sleep-inducing pasta roofie than an aphrodisiac, Kazdin swears by their magical alchemy.
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Herding bills through Congress to the point of signing requires a tolerance for patient negotiating and a command of sleep-inducing detail.
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When your eyes are exposed to it directly, it halts production of the sleep-inducing hormone melatonin and makes you feel alert.
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Research has shown that this method likely works because the short power nap helps clear the brain of the sleep-inducing compound adenosine.
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A calming, sleep-inducing scent is not ideal for waking up and an invigorating scent wouldn't be the best to fall asleep to.
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But Alfred Wiater, a somnologist, says that longer daylight in the evening can indirectly delay sleep by disrupting the metabolism of sleep-inducing melatonin.
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Though you may not realize it, besides gifting us with their savory, sleep-inducing meat, turkeys have also provided us with tons of hilarious content.
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When your eyes are exposed to it directly, the blue light halts production of the sleep-inducing hormone melatonin and makes you feel more alert.
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It began inhaling air with all its might, and suddenly, every cloud of sleep inducing smoke converged directly below it, and I was caught out.
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Those dull moments of mining and flying around featureless landscapes for minutes at a time are downright sleep-inducing unless you've got the mindset for it.
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For the first two hours of the 58th Annual Grammy Awards, performances were at worst sleep-inducing and at best entertaining in the most PG way.
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Blame all that bright blue light, which was found to suppress levels of the sleep-inducing hormone melatonin by 55 percent in the e-reading group.
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"Ladies and gentlemen of Texas," he then droned in a sleep-inducing staccato monotone the way he imagined most of the other 44 presidents had done.
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The misconception that late-night workouts help you pass out is totally off-base, since exercise tends to raise your cortisol levels and suppress sleep-inducing melatonin.
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Word of the Day adjective: sleep inducing adjective: inducing mental lethargy noun: a drug that induces sleep _________ The word soporific has appeared in 13 articles on nytimes.
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For starters, turkey may be loaded with tryptophan, the amino acid that's a precursor to the sleep-inducing serotonin, but so is just about any high-protein food.
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The herbalist Susan Weed also refers to hops as a nutritive painkiller, a sleep-inducing herb, and as an effective supplement to boost milk production in lactating women.
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Turn on his or her favorite channel if you forgot to do so before you left, or switch the music from relaxing to sleep-inducing to reinforce a schedule.
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That might include sticking to a rigid sleep schedule, changing around your sleep-inducing medications, and/or taking stimulants to help keep you awake when you need to be.
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Nice photos from a friend's latest vacation, funny memes, kitschy sunsets, cute animals and/or babies, footage of Snoop Dogg smoking blunt after blunt—it's prime sleep-inducing fodder.
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This column is nominally about network neutrality, the often sleep-inducing debate about the rules that broadband companies like Comcast and AT&T must follow when managing their networks.
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But the pods are made using sativa strands, which are often associated with feelings of alertness, intense focus, and creativity rather than the sleep-inducing effects of indica-heavy varieties.
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But, the entire situation is even worse than one would expect since Kathryn accidentally took an Adderall pill from Lewis' Jandice, thinking it was a dose of sleep-inducing Ambien.
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The Neal's Yard Soothing Bath Oil is a sleep-inducing lavender-based blend and is housed in a glass bottle that can be turned into a great vase when finished.
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He'd snuck out of his bed while a boy named James was wailing and weeping loud enough to make the whirlybird drift over to him with its sleep-inducing syringe.
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She has founded two companies, a namesake lingerie line and WelleCo, a wellness and supplements company that is introducing a sleep-inducing tea and calming essential-oil mist this month.
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A "Sleep-inducing pill?" sounds like we are supposed to be thinking about a sedative, but in this puzzle, the word "pill" means someone who is annoying or boring. 65A.
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He also advises people avoid their cell phones before bed in part because the devices emit short-wavelength blue light that slow the production of the sleep-inducing hormone melatonin.
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Razzie founder John Wilson called "Fifty Shades Darker," based on the best-selling erotic novels, "more sleep-inducing than sexy," while the reboot of "Baywatch" was among the worst picture contenders.
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It's those tingles that some people feel in their brains when watching something soothing, but you don't need to have it to admit that this video is both satisfying and sleep-inducing.
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JW: I needed something that would get me to keep cracking open the books and writing code on the whiteboard every day, even though it was terribly intimidating and sometimes sleep-inducing.
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Foods laden with this amino acid are also loaded with a bunch of other amino acids that block your brain from absorbing the tryptophan and turning it into the sleep-inducing serotonin.
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When your eyes are exposed to it directly (not through a window or while wearing sunglasses), the blue light halts production of the sleep-inducing hormone melatonin and makes you feel more alert.
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Working with researchers from the University of Sydney's Charles Perkins Center, Qantas offers lemon and ginger kombucha, wake-up shots of probiotic-infused juice and sleep-inducing tea in its top two classes.
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Armed with a stun gun, and what looked like a pistol—it was actually a toy water gun—the intruder zip-tied the couple and forced them to drink a sleep-inducing drug cocktail.
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There is hardly any supporting research, just anecdotal evidence, that shows the potential of weighted blankets having the same arousal-reducing effects as well as sleep-inducing ones in adult populations, including combat veterans like Petrulis.
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On Friday, the app will release the ultimate sleep-inducing story: a reading of the first chapter of Adam Smith's 1776 economics book The Wealth of Nations in a droning voice by everyone's favorite economics teacher, Stein.
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But mostly I registered the fact that she was to give a speech on the theme of "community and belonging," and that, like other festival speeches of this sort, there was a good chance it could be sleep-inducing.
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In an ideal world, by which I mean an un-ideal world without recessed lighting and iPads, the sun sets, it becomes dark, and, presto, your pineal gland starts to release the sleep-inducing hormone melatonin (and a few other hormones).
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He collaborated with Keefus Ciancia, the composer and music producer, on a truly weird collection of quasi-bedtime stories, musings about death and also a humming song, with Mr. Bridges's familiar gruff voice and all manner of ambient sounds that many listeners found more alarming than sleep-inducing.
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But the puppets representing the ghosts of the explorer Hendrick Hudson and his crew (who provide Rip that sleep-inducing cider) were made from salvaged materials at "community build" sessions at Safe Harbors, a nonprofit community arts and housing organization in Newburgh, N.Y. The cast was similarly gathered from 15 towns across the valley through a series of storytelling workshops and auditions, and reflects the changing demographics of a region where gentrification, immigration and inequality are hotly debated.
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GameSpot thought the game would appeal to adventure fans. Gamekult derided the game's difficult puzzles, sleep-inducing dialogue, and lack of plot momentum.
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Jeremy Magadevan of the New Straits Times described the novel as "sleep-inducing" and said that readers should "mail it to a terrorist and wait for him to die of boredom".
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Garland, p. 268 Pillows stuffed with dried hops are an old treatment for insomnia.Chopra, p. 40 A sachet of hops is traditionally placed under a child's pillow to deliver sleep-inducing aromatherapy.
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Typically, the sleep inducing properties of hypnotics occur within 0.5 hours. In some cases, as with temazepam and nitrazepam, strong hypnotic effects can be felt 15 to 20 minutes after oral ingestion.
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Opium was also known to the Greeks. It was valued by Hippocrates (c. 460 – c. 370 BC) and his students for its sleep- inducing properties, and used for the treatment of pain.
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It also helps prepare the body for sleep. Administration of melatonin at any time may have a mild hypnotic (sleep-inducing) effect. The expected effect on sleep phase timing, if any, is predicted by the PRC.
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The species name somnifera means "sleep-inducing" in Latin. The name, ashwagandha, is a combination of the Sanskrit words ashva, meaning horse, and gandha, meaning smell, reflecting that the root has a strong horse-like odor.
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Another study examined the short-term effects of the accumulation of temazepam over seven days in elderly inpatients, and found little tolerance developed during the accumulation of the drug. Other studies examined the use of temazepam over six days and saw no evidence of tolerance. A study in 11 young male subjects showed significant tolerance occurs to temazepam's thermoregulatory effects and sleep inducing properties after one week of use of 30-mg temazepam. Body temperature is well correlated with the sleep-inducing or insomnia-promoting properties of drugs.
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The Belgian newspaper De Standaard even called it "sleep inducing". The artwork was reviewed as superior but sloppy at times, but the painted pages that are interspersed throughout the album are consistently receiving a positive response from reviewers.
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Kava is under preliminary research for its potential psychoactive - primarily anxiolytic - sleep-inducing, and sleep-enhancing properties. Preliminary randomized controlled trials in anxiety disorders indicate a higher rate of improvement in anxiety symptoms after kava treatment, relative to placebo.
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Armed with a sleep-inducing candle (made from the tallows of his victims), the Mago tracks her down in France where she has become queen. But Francesca blows out the candle, rendering the Mago helpless as he meets his death by the mob alerted by the queen's call for help.
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Tolerance to nitrazepam's effects occurs with regular use. Increased levels of GABA in cerebral tissue and alterations in the activity state of the serotoninergic system occur as a result of nitrazepam tolerance. Tolerance to the sleep-inducing effects of nitrazepam occurs after about seven days; tolerance also frequently occurs to its anticonvulsant effects.
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These statements drew criticism as they describe the exact opposite of benzodiazepines, which actually work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor. By enhancing the effects of GABA, benzodiazepines use results in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant effects.
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Things get worst when both think of filing for a divorce. Indira leaves her in-law's house even heartlessly discarding her kids. Devastated Madhu becomes mentally ill and takes sleep inducing injections to forget his troubles. At this juncture, Madhu's sister Saroja (Geethanjali) introduces her friend Anuradha (Sarada) when spotting her applicable nature Madhu's mother makes him remarry Anuradha.
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31 The word has also been used to mean a small bag of any material, e.g., paper, foil, or plastic, used to package doses of medication, for example, sleeping powders. Some "dream pillow" types of scented sachets (i.e. "hop pillows") are made with sleep inducing ingredients like hops, chamomile, valerian, skullcap, and lavender that help promote sleep.
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A lettuce sandwich has been claimed to be a sleep-inducing remedy for insomnia. Lettuce sandwiches (no bread) are also eaten to promote weight loss. Lettuce sandwiches (bread filled with lettuce) can also be a good food choice for the health-conscious. The lettuce sandwich (bread filled with lettuce)—which contains no meat—is mentioned in a book about vegetarian diets.
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Like Virgil, Ovid associates Somnus with the underworld's river Lethe, which Ovid has flowing from the bottom of Somnus' cave, and "whose waves, gently murmuring over the gravelly bed, invite to slumber."Ovid, Metamorphoses 11.602-604. Near the entrance bloom sleep-inducing poppies and other herbs, which Nox (Night) uses to spread sleep over "the darkened lands."Ovid, Metamorphoses 11.605-607.
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Automatism, in toxicology, refers to a tendency to take a drug over and over again, forgetting each time that one has already taken the dose. This can lead to a cumulative overdose. A particular example is barbiturates which were once commonly used as hypnotic (sleep inducing) drugs. Among the current hypnotics, benzodiazepines, especially midazolam might show marked automatism, possibly through their intrinsic anterograde amnesia effect.
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Sify wrote, "Action King Arjun’s maiden directorial Vedham is sleep inducing. Arjun should stick to patriotism, guns and scantly clad girls dancing in ribaldry. But here he wants to experiment with the idea – “To be in love for ever” but ends up making an insufferable film that leaves you with a migraine'. The Hindu wrote, "Generally it is patriotism that is the underlying theme of Arjun's films.
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Hayaishi, along with group members, is recognized for his great contributions to biomedical sciences and enzymology, especially the discovery of Oxygenases group of enzymes. These enzymes are widely distributed in nature and represent a unique group of respiratory enzymes that catalyze the direct incorporation of molecular oxygen into various substrates. Hayaishi is also known for his discovery of the sleep-inducing action of Prostaglandin D2.
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His collected Opere appeared in 1868. When in 1854 Beatrice Cenci was lambasted by Francesco de Sanctis (who now favored the House of Savoy leadership for Italy), he wrote to a friend: "Honoured Alessandro Manzoni, I am put down... to think that as far back as '40 Britons and Germans saw us as leaders of two different schools, and his they labelled sleep-inducing".
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Quazepam has potent sleep inducing and sleep maintaining properties. Studies in both animals and humans have demonstrated that EEG changes induced by quazepam resemble normal sleep patterns whereas other benzodiazepines disrupt normal sleep. Quazepam promotes slow wave sleep. This positive effect of quazepam on sleep architecture may be due to its high selectivity for type1 benzodiazepine receptors as demonstrated in animal and human studies.
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Tolerance develops rapidly to the sleep-inducing effects of benzodiazepines. The anticonvulsant and muscle-relaxant effects last for a few weeks before tolerance develops in most individuals. Tolerance results in a desensitization of GABA receptors and an increased sensitization of the excitatory neurotransmitter system, such as NMDA glutamate receptors. These changes occur as a result of the body trying to overcome the drug's effects.
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A geroprotector is a senotherapeutic that aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.De- novo geroprotector design, SENS Foundation Some possible geroprotectors include melatonin, carnosine, metformin, nicotinamide mononucleotide (NMN)Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age- Associated Physiological Decline in Mice, Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc. and delta sleep-inducing peptide.
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The use of sleep-inducing medication could be indicative of poor sleep due to disturbances. A study in 1997 showed that sleep structure as well as the restorative component of sleep may be disrupted while in space. These disturbances could increase the occurrence of performance errors. Current space flight data shows that accuracy, response time and recall tasks are all affected by sleep loss, work overload, fatigue and circadian desynchronization.
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The Earthmen doused the entire city with a sleep- inducing gas, but before that Anton-Rumata had fought his way through the city towards the palace, covered in blood, where he finally killed Reba. Remembering their childhood, Pashka wonders whether that episode, when Anton decided to disobey a "wrong way" sign, and found 'a skeleton of a fascist', had a deeper meaning, but he does not say what that meaning is.
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In the case of trypanosome infection, tryptophol decreases the immune response of the host. As it is formed in the liver after ethanol ingestion or disulfiram treatment, it is also associated with the study of alcoholism. Pyrazole and ethanol have been shown to inhibit the conversion of exogenous tryptophol to indole-3-acetic acid and to potentiate the sleep-inducing hypothermic effects of tryptophol in mice. It is a growth promoter of cucumber hypocotyl segments.
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For example, fever therapy consisted of inducing a fever in the patient using various methods, such as the malaria virus, but did not produce effective results in the treatment of schizophrenia. Sleep therapy was carried out using sleep- inducing substances such as marijuana, opium, and somnifen. Bowman also addresses stimulus therapy; this method had only temporary effects. Bowman recommended the insulin method as effective, with longer-lasting effects and more indications of long-term improvement.
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Increased endocannabinoid signaling within the central nervous system promotes sleep- inducing effects. Intercerebroventricular administration of anandamide in rats has been shown to decrease wakefulness and increase slow-wave sleep and REM sleep. Administration of anandamide into the basal forebrain of rats has also been shown to increase levels of adenosine, which plays a role in promoting sleep and suppressing arousal. REM sleep deprivation in rats has been demonstrated to increase CB1 receptor expression in the central nervous system.
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Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. High doses of many shorter- acting benzodiazepines may also cause anterograde amnesia and dissociation. These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures. Benzodiazepines are categorized as either short, intermediary, or long-acting.
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In terms of natural occurrence, oleamide was first detected in human plasma. It was later shown to accumulate in the cerebrospinal fluid during sleep deprivation and induces sleep in animals. It has been considered as a potential treatment for mood and sleep disorders, as well as cannabinoid- regulated depression.Methods of treating anxiety and mood disorders with oleamide – US Patent 6359010 In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems.
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Finally Lao Tzu comes and tells the Emperor that his Pills of Immortality have been stolen. This time, both General Li and the God of the North Star recommend military action. The Heavenly army descends on the Flower and Fruit Mountain, where there is heavy fighting between the soldiers and well trained monkeys. Sun Wukong fights and defeats the Four Heavenly Kings, who use a variety of weapons ranging from a sleep-inducing lute to a magical snake.
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The Associated Press labeled the game "unwatchable." Mark Tracy of the New York Times declared it a "sluggish slog of a national title game." Myron Medcalf, writing for ESPN, wrote that the game was blighted with "an abundance of foul calls, poor offense and a sleep- inducing rhythm." Chris Chase of Fox Sports lamented how the referees had "ruined" the contest through a combination of incorrect foul calls, missed calls, and superfluous use of instant replay.
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She dopes the bear's watering fountain with a sleep-inducing infusion of herbs, honey, and milk, and Harap Alb wrapped in bearskin gathers the salad before the beast awakes. Harap-Alb's second dangerous assignment is to hunt the enchanted deer whose skin is studded with precious stones, and to bring back its skull and hide. The deer's stare strikes one dead and no one has ever survived. Saint Sunday provides him with the visor and sword of (a dwarfish character).
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He also listens as the three brothers plot to break into Billy's home and steal his presents. They also attempt to write a letter to Santa claiming they have been good, but Santa's voice informs them that he can see all that they do. Merlin the wizard, Santa's most trusted assistant, gives Santa a sleep inducing powder and a flower that allows him to disappear. He then retrieves a magic key that will open any door on Earth and prepares his mechanical reindeer.
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Several in vitro studies have shown that zapotin has potential anticarcinogenic effects against isolated colon cancer cells. The fruit has long been thought to produce drowsiness, as claimed by Francisco Hernández de Toledo in the 16th century, but this may be a misinterpretation of the Nahuatl name of the plant, cochitzapotl (meaning '"sleep-sapote"), as its seeds were processed to produce a poison by the Aztecs, and the seeds and leaves, but not fruit pulp of the plant, contain sleep-inducing compounds.
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Alternative treatments such as massage, relaxation techniques (meditation, essential oils, spa baths, music therapy, etc.), gentle stretching, and especially heat therapy have been successfully used to an extent in conjunction with pain medications. A majority of CED patients require some form of analgesics, muscle relaxant, and/or sleep inducing medication to manage the pain, specifically if experiencing frequent or severe 'flare-ups' (e.g. during winter).Jadhav, A. T. U. L., & Ghanekar, J. A. I. S. H. R. E. E. (2013).
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Renuka Vyavahare of Times of India wrote, "While the story is relevant, setting authentic and performances decent, the sluggish pace is sleep-inducing." Vyavahare also noted that while the socio-political issues raised by the film were important, the meaning is lost as the characters come across as hypocritical. "Sadly, all they do is preach and then commit an idiotic crime themselves, much against their own values and beliefs." Vyavahare subsequently gave the film a rating of two stars out of five.
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Ken Tucker of Entertainment Weekly said Annie was as every bit "hootable" as Olivia, but more "bratty and greedy". Julia Shih of The Michigan Daily criticised Sunset Beach for its slow-paced episodes, opining that Annie's arrest should have been over in a few minutes rather than taking up an entire episode. She added it made the episode halt to a "sleep-inducing state". The Boston Herald included Annie's various fights with Meg in their feature on the most memorable soap opera moments during 1997.
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In addition, the preliminary experiments in dogs by Haulica et al. (J. Neurochem. 21:,1019–20, 1973) and the administration of adenosine into the brains of rats, cats and fowl suggested that adenosine was able to produce behavioral sleep. The explanation of adenosine's hypnotic effect was through its interaction with serotonin, widely believed to be a sleep inducing agent. However, since there was no suggestion how this adenosine-serotonin link was achieved, experiments highlighting the potential role of adenosine in sleep had largely been forgotten.
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Given the possible role of hyperactive GABAA receptors in idiopathic hypersomnia, medications that could counteract this activity are being studied to test their potential to improve sleepiness. These currently include clarithromycin and flumazenil. Flumazenil, a GABAA receptor antagonist is approved by the FDA for use in anesthesia reversal and benzodiazepine overdose. Research has shown that flumazenil provides relief for most patients whose CSF contains the unknown "somnogen" that enhances the function of GABAA receptors, making them more susceptible to the sleep-inducing effect of GABA.
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They form a court to try Allan, build up false charges against him and sentence him to death by shooting. As the party move away to deliberate on how to execute him, Allan's servant spies on them and a plot is made of how to rescue him from death. They drug Allan's coffee with sleep inducing herbs brought by his servant, dresses him in Marie's clothes and then hide him in a grain pit leaving Marie in his place of detention. In the morning, Marie is taken out for execution.
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In 1885/86 he was university rector. During the Austro- Prussian War (1866) and Franco-Prussian War (1870–71) he served as a staff physician. In 1867 he discovered that quinine was highly toxic to micro- organisms in impure water, and demonstrated that quinine hydrochlorate with neutral or slightly basic reaction was an effective poison for the protoplasms of decomposing plants and impeded many fermenting and putrid processes. In addition to his research of quinine, he performed extensive pharmacological tests on arsenic, halogens and associated compounds, sleep-inducing substances, et al.
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In 1994, the Siuzdak lab while working with Richard Lerner (then president of The Scripps Research Institute), used liquid chromatography mass spectrometry to perform metabolomics experiments on the cerebral spinal fluid from sleep deprived animals. One molecule of particular interest, oleamide, was observed and later shown to have sleep inducing properties. This work is one of the earliest such experiments combining liquid chromatography mass spectrometry and activity metabolomics to identify active metabolites. In 1996 whole virus analysis was performed with an electrospray ionization mass spectrometer where the virus was collected and successfully tested for viability.
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Next, Insouciant would place a set amount of magic on both of Yang Ren's eyes (because Yang Ren previously had his eyes removed as punishment by King Zhou of Shang). Following this, Zhenjun would blow on Yang Ren's face and tell him to awaken. Following this point, Zhenjun would have Yang Ren as his disciple for the remainder of his allotted time. When Huang Feihu had been completely surrounded by Wen Zhong's forces, Zhenjun would engulf Huang and his entourage in a sleep-inducing fog and would then move them outside the valley.
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Many futuristic devices are described in the series, some of which have since become reality, including the flying wing, the answering machine, television, automatic transmission, night vision goggles, electromagnetic rail guns, and a hand-held automatic weapon, known variously as the machine pistol, the supermachine pistol, or the rapid-firer. A wide range of ammunition types were used for the machine pistols, including incendiary bullets that smash on contact, coating the target with a high- temperature paste-fed fire, high explosive bullets able to uproot trees, ordinary lead bullets, and the sleep-inducing "mercy bullets".
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Chronic or excessive use of temazepam may cause drug tolerance, which can develop rapidly, so this drug is not recommended for long-term use. In 1979, the Institute of Medicine (USA) and the National Institute on Drug Abuse stated that most hypnotics lose their sleep-inducing properties after about three to 14 days. In use longer than one to two weeks, tolerance will rapidly develop towards the ability of temazepam to maintain sleep, resulting in a loss of effectiveness. Some studies have observed tolerance to temazepam after as little as one week's use.
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This approach was of interest since Michel Jouvet's Monoamine Theory of Sleep, with serotonin as the sleep inducing agent, was dominant at the time. From 1970 to 1984, at the University of Illinois, Radulovacki published a series of papers dealing with the role of monoamines in sleep. In 1970, Radulovacki was recruited by Klaus Unna to join the Department of Pharmacology in the College of Medicine at the University of Illinois at Chicago as an Assistant Professor. Radulovacki published more than 170 scientific papers during his career at the UIC.
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Flumazenil is the only GABAA receptor antagonist on the market as of Jan 2013, and it is currently manufactured only as an intravenous formulation. Given its pharmacology, researchers consider it to be a promising medication in the treatment of primary hypersomnias. Results of a small, double-blind, randomized, controlled clinical trial were published in November 2012. This research showed that flumazenil provides relief for most people whose CSF contains the unknown "somnogen" that enhances the function of GABAA receptors, making them more susceptible to the sleep-inducing effect of GABA.
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He found the album sleep-inducing, and cited the lyrics 'I wanna bathe you in the light of day/and just watch you as the rays/tangle up around your face and body… the daylight seems to want you/just as much as I want you' as such. He felt that the sentiment felt like it had originated in a junior-high diary and was never used. According to review aggregator website Metacritic, the album has received an average critic score of 67/100, which translates to "generally favorable reviews". A Hundred Million Suns was a moderate chart success.
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In The Washington Post, Gil Grifin noted that "musically and conceptually", the band are "reaching for its glorious past" which resulted in an album not entirely appealing. Though "Lift Me Up", "The More We Live – Let Go" and "Saving My Heart" are picked as more favourable tracks, Grifin concludes with "the aloofness of 'Union' is often sleep-inducing". Union received two and a half stars out of five in a retrospective review by Bruce Eder for AllMusic. Eder thought it was always difficult for the album to live up to expectations given the amount of musical talent involved.
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While one text group only goes as far as to say the mermaids dismembered Roth, alternate texts says that they devoured him, so that only the thigh bone drifted ashore. Thus, like the mermaids in O'Clery's version, the half-beautiful mermaids here sang sleep-inducing "burdens" or musical refrains, tore their victims apart, and ate them. Whitley Stokes noted that the description of mermaids here coincides with the description of sirens in the ', or rather the medieval European bestiaries, particularly that of . There are several onomastic tales which attempts to explain the name origin of (Assaroe Falls), one of which involves mermaid music (').
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Super 3D Noah's Ark plays similarly to Wolfenstein 3D, and utilizes the same game engine. The game plays similarly to Wolfenstein 3D, but the graphics were changed to reflect a non- violent theme. Instead of killing Nazi soldiers in a castle, the player takes the part of Noah, wandering the Ark, using a slingshot to shoot sleep-inducing food at angry attacking animals, mostly goats, in order to render them unconscious. The animals behave differently: goats, the most common enemy, will only kick Noah, while the other animals such as sheep, ostriches, antelopes and oxen will shoot spittle at him from a distance.
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Robert Canning of IGN was not impressed: "Perhaps if it had been sung with more feeling, it could have worked better." For "Take Care of Yourself", both West and The Hollywood Reporter Lesley Goldberg agreed with Rachel's assessment that the performance was "magical", and West graded it with an "A+". The Los Angeles Times Amy Reiter was "blown away", and Jen Chaney of The Washington Post gave it an "A" with the comment that Rory "handled it with adorable aplomb". Michael Slezak of TVLine and The A.V. Club Emily VanDerWerff, however, thought the number was somewhat sleep-inducing.
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Invented by Jack Kevorkian, who used this device and called it a "Thanatron" or death machine after the Greek daemon, Thanatos. It worked by pushing a button to deliver the euthanizing drugs mechanically through an IV. It had three canisters mounted on a metal frame. Each bottle had a syringe that connected to a single IV line in the person's arm. One contained saline, another contained a sleep-inducing barbiturate called sodium thiopental and the third a lethal mixture of potassium chloride, which immediately stopped the heart, and pancuronium bromide, a paralytic medication to prevent spasms during the dying process.
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Lust, p. 370 A small pillow filled with dried hops and slept on is a well-known folk remedy in many European countries for inducing a calm, restful sleep.How To Make Herbal Pot- Pourris, Sachets And PillowsHere's How To Make a Dream Pillow Dream pillows are used to promote restful sleep and pleasant dreams. They are small and flat, placed in a standard pillow, and stuffed with a sachet of calming and sleep-inducing dried herbs... George Washington reportedly used one filled with hops... These scented sachets of aromatic herbs are also referred to as "herb pillows" or "sleep pillows" and are designed to overcome sleeplessness.
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Tolerance occurs to the muscle- relaxant, anticonvulsant, and sleep-inducing effects of benzodiazepines, and upon cessation a benzodiazepine withdrawal syndrome occurs. This can lead to benzodiazepines being taken for longer than originally intended, as people continue to take the drugs over a long period of time to suppress withdrawal symptoms. Some people abuse benzodiazepines at very high doses and devote a lot of time to doing so, satisfying the diagnostic criteria in DSM IV for substance abuse and dependence. Another group of people include those on low to moderate therapeutic doses of benzodiazepines who do not abuse their benzodiazepines but develop a tolerance and benzodiazepine dependence.
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Like its more toxic relatives, Nicandra physalodes is alkaloidal, analyses having revealed the presence of the tropane alkaloid tropinone and the pyrrolidine alkaloid hygrine (0.1%, in the root). Withanolides are found almost exclusively in plants of the Solanaceae and, while it is noticeable that many psychoactive species belonging to that family contain only, or primarily, such compounds, not a single withanolide has yet been proven to be psychoactive. The compounds are named for the Solanaceous genus Withania, the best-known species of which, Withania somnifera, is, as its specific name suggests, mildly psychoactive to the extent of being sleep-inducing (among other useful medicinal properties). The use of W.somnifera (common name (i.
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Kramer adds Newman as a co-host for his "show" to help relieve the pressure of being a host. On his "show", Jerry says he has finally found a way to play with the toys, by accidentally drugging his girlfriend with sleep inducing medication; Kramer is shocked by Jerry's scheme. Miranda insists that George pay for a surgery required to save the squirrel's life instead of putting it to sleep. Elaine gives Tic Tacs to the sidler to make him noisy; unfortunately, the sound annoys J. Peterman, which reminds him of an old Haitian torture method and if he hears another rattle, Elaine will be fired (since he mistakenly believes it was her all along).
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The Piranha was a normal piranha fish mutated by radiation into a semi-humanoid being with sub-human intelligence. The Piranha had superhuman physicality, teeth that were strong and sharp enough to penetrate Namor's skin,Sub-Mariner #71 (May, 1974) claws that were equally as incisive made deadlier by a sleep-inducing venom they generated and the power to command other fish telepathically.Marvel Two-In-One #28 (June, 1977) Piranha could increase its intellect by consuming the remains of anyone it came across, effectively adding their knowledge, memories and acumen to its own. The creature also boasts a regenerative healing factor powerful enough to physically restore him even from being devoured by his own Men-Fish,Defenders vol.
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Heroin, a powerful opioid and narcotic The term narcotic (, from ancient Greek ναρκῶ narkō, "to make numb") originally referred medically to any psychoactive compound with sleep-inducing properties, and euphoric properties as well. In the United States, it has since become associated with opiates and opioids, commonly morphine and heroin, as well as derivatives of many of the compounds found within raw opium latex. The primary three are morphine, codeine, and thebaine (while thebaine itself is only very mildly psychoactive, it is a crucial precursor in the vast majority of semi-synthetic opioids, such as oxycodone or hydrocodone). Legally speaking, the term "narcotic" may be imprecisely defined and typically has negative connotations.
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In a dystopian, near-future Los Angeles, city tax collector Nixon is badly injured during a violent encounter with one of his targets, and undergoes extensive surgery in order to survive. Nixon wakes up in a bedroom sometime later, believing his previous experience was a bad dream, and that he is really Carl Seltz, an insurance investigator for the Benevolent Assurance Corporation, with a wife, two children, a dog, and a normal life. However, when his persistent dreams disturb his sleep, his wife distracts him with sex while his children inject him with a sleep-inducing drug, indicating not all is as it seems with Carl's "normal" life. The next day, Carl heads out to pursue a delinquent account, talking to himself the whole way.
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In 1956, researchers at SKF involved in clinical trials noted that even when used in very high doses, thalidomide could not induce sleep in mice. And when administered at doses 50 to 650 times larger than that claimed by Chemie Grünenthal to be "sleep inducing", the researchers could still not achieve the hypnotic effect in animals that it had on humans. After completion of the trial, and based on reasons kept hidden for decades, SKF declined to commercialize the drug. Later, Chemie Grünenthal, in 1958, reached an agreement with William S Merrell Company in Cincinnati, Ohio, (later Richardson-Merrell, now part of Sanofi), to market and distribute thalidomide throughout the US The US FDA refused to approve thalidomide for marketing and distribution.
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Using this past criticism, they gave similar stealth abilities to Sombra, but in combination with the hacking skills as to be a more effective contribution to the team regardless of their opponents' style. Goodman noted that they were initially hesitant about incorporating skill debuffs into the game, knowing that players would likely react negatively to having skills stripped even for a short period of time. However, they were emboldened by the successful playtesting of Ana and her sleep-inducing ability which they were able to tweak quickly in response to feedback, and believed they would be able to manage Sombra's hacking skills in the same manner. In terms of Overwatch's characters, they wanted to bring more villain-like characters to the game, according to Goodman.
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The film was awarded four stars out of five by Empire magazine's Ian Freer, who called it funny but described the humor as sometimes hit-and-miss. Conversely, Los Angeles Times Jack Mathews labeled the film as sleep-inducing and "by far the most inane and badly written of the comedies made by any of the creators of the classic 1980 sendup Airplane!". Michael O'Sullivan in The Washington Post' called the film "dark, dull, witless and hobbled by poor comic timing," comparing its gross-out humor unfavorably to that of There's Something About Mary. Roger Ebert echoed this sentiment in his negative review in the Chicago Sun-Times, giving the film one and a half stars out of four and saying the film "tries to buy laughs with puerile shocks".
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Wisdom Tree holds the distinction of having made the only unlicensed game ever commercially released for the American Super Nintendo Entertainment System, Super 3D Noah's Ark. This conversion of the Wolfenstein 3D engine featured the player as Noah, attempting to quell upset animals on the Ark by flinging sleep-inducing fruit at them. Its shape (the only American SNES cartridge to not use the standard Nintendo-manufactured shell) resembles that of the SNES Game Genie or Sonic & Knuckles on the Sega Genesis, with a pass-through cartridge port at the top; the game requires an "official" Nintendo-licensed cartridge plugged into this pass-through, which allows the game to bypass the SNES's lockout protection and boot up. A PC port of the game was released on Steam in 2015, with retouched features such as support for widescreen resolutions and achievements.
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The modern pharmaceutical industry began with local apothecaries that expanded from their traditional role distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mid-1800s, and from discoveries resulting from applied research. Intentional drug discovery from plants began with the isolation between 1803 and 1805 of morphine - an analgesic and sleep-inducing agent - from opium by the German apothecary assistant Friedrich Sertürner, who named this compound after the Greek god of dreams, Morpheus.Multinational corporations including Merck, Hoffman-La Roche, Burroughs-Wellcome (now part of Glaxo Smith Kline), Abbott Laboratories, Eli Lilly and Upjohn (now part of Pfizer) began as local apothecary shops in the mid-1800s. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from tar and other mineral sources and had also established rudimentary methods in organic chemical synthesis.
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In 1995 liquid chromatography mass spectrometry metabolomics experiments were performed by Gary Siuzdak while working with Richard Lerner (then president of The Scripps Research Institute) and Benjamin Cravatt, to analyze the cerebral spinal fluid from sleep deprived animals. One molecule of particular interest, oleamide, was observed and later shown to have sleep inducing properties. This work is one of the earliest such experiments combining liquid chromatography and mass spectrometry in metabolomics. In 2005, the first metabolomics tandem mass spectrometry database, METLIN, for characterizing human metabolites was developed in the Siuzdak laboratory at The Scripps Research Institute. METLIN has since grown and as of July 1, 2019, METLIN contains over 450,000 metabolites and other chemical entities, each compound having experimental tandem mass spectrometry data generated from molecular standards at multiple collision energies and in positive and negative ionization modes.
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Xanax (alprazolam) 2 mg tri-score tablets A benzodiazepine (sometimes colloquially "benzo"; often abbreviated "BZD") is a drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring. The first such drug, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann–La Roche, which has also marketed the benzodiazepine diazepam (Valium) since 1963. Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties; also seen in the applied pharmacology of high doses of many shorter-acting benzodiazepines are amnesic- dissociative actions. These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures.
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Laryngoscopes prepared for emergency anaesthesia Rapid sequence induction and intubation (RSI) is a particular method of induction of general anesthesia, commonly employed in emergency operations and other situations where patients are assumed to have a full stomach. The objective of RSI is to minimize the possibility of regurgitation and pulmonary aspiration of gastric contents during the induction of general anesthesia and subsequent tracheal intubation. RSI traditionally involves preoxygenating the lungs with a tightly fitting oxygen mask, followed by the sequential administration of an intravenous sleep-inducing agent and a rapidly acting neuromuscular-blocking drug, such as rocuronium, succinylcholine, or cisatracurium besilate, before intubation of the trachea. One important difference between RSI and routine tracheal intubation is that the practitioner does not manually assist the ventilation of the lungs after the onset of general anesthesia and cessation of breathing, until the trachea has been intubated and the cuff has been inflated.
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" He noted a multitude of issues: "an ammunition of boredom in terms of a sketchy plotline, bad acting, lazy script, silly dialogues and a sleep-inducing love story with almost zero chemistry." Thakur also called the film very predictable and the performances of the actors as "straight-faced" and "so off the mark that they will make even a newcomer look better in front of them." Finally, Thakur concluded by urging the reader to "skip Namaste England," calling it a "complete waste of time." Kunal Guha of Mumbai Mirror also gave the film 1.5 out of 5 stars, summarizing the film by saying: " The lack of conflict or chemistry between the lead couple, tedious dialogue and a mumbling monologue on how being an Indian is a matter of well-deserved pride (similar to the one in Namaste London (2007), minus the impact) restrict this story from taking any definitive direction.
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Fionn fighting Aillen, illustration by Beatrice Elvery in Violet Russell's Heroes of the Dawn (1914) One feat of Fionn performed at 10 years of age according to the Acallam na Senórach was to slay Áillen (or ), the fire-breathing man of the Tuatha Dé Danann, who had come to wreak destruction on the Irish capital of Tara every year on the festival of Samhain for the past 23 years, lulling the city's men to sleep with his music then burned down the city and its treasures. When the King of Ireland asked what men would guard Tara against Áillen's invasion, Fionn volunteered. Fionn obtained a special spear (the "Birga") from Fiacha mac Congha ("son of Conga"), which warded against the sleep-inducing music of Áillen's "dulcimer" () when it was unsheathed and the bare steel blade was touched against the forehead or some other part of the body. This Fiacha used to be one of Cumall's men, but was now serving the high-king.
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Each is also an extraordinary industrial spy and saboteur, master of disguise, a superb actor, a highly agile and skilled athlete, and greatly skilled in the uses of virtually any kind of gun. Spymaster always has access to cutting-edge technology for a number of espionage-related devices and weapons, both of his own design and those of Justin Hammer's. The original Spymaster used various special devices including, devices in his gloves and mask that projected concussive energy blasts, small and powerful hovering electromagnets, incendiary missiles, "razor-discs" that could pierce Iron Man's armor, devices that enabled him to absorb Iron Man's repulsor energy, stunguns, sleep inducing "somnu-gas", boot jets that allowed flight, and a device in his belt buckle that summoned an advanced model hovercraft that could operate automatically according to pre-programmed instructions. Both the first and second Spymasters have employed electronically amplified nun-chakas that can damage Iron Man's armor.
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It is thought that since ancient times, it was widely believed in Japan that the soul leaves the body while dreaming, and the soul cannot return to the body if the pillow is flipped during that time. In the historical tale Ōkagami written in the final years of the Heian period, there is a statement about how Fujiwara no Yoshitaka left a will that said that on his death, he would make sure to return to this world, so there will be no funeral by the usual customs, but despite this, a normal funeral was held with the pillow's position corrected to face north, so his wish to revive was not granted. The folklorist Akira Takeda notes that the pillow contains a person's living spirit or ikiryo, and to turn the pillow would mean to put that person closer to death. The folklorist Miyata Noboru notes that in the past in Japan, dreaming was thought of as a way to go to another world, and in order to dream, people would kindle a sleep-inducing aroma into their hakomakura (箱枕, box pillow).
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