They plan to use a sedative drug called midazolam, which has been shown in studies to produce a kind of amnesia that can temporarily prevent people from forming new memories.
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In the sworn testimony, Cosby admitted to having sexual relations with Constand and to obtaining the sedative drug Quaaludes to give them to women with whom he wanted to have sex.
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It is also a DEA List I Chemical because of its use in making the now-widely outlawed euphoric sedative drug methaqualone (Quaalude, Mandrax).
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Piperidione (trade name Sedulon) is a sedative drug, structurally related to methyprylon and pyrithyldione. It used to be marketed by Roche as a cough medicine available in liquid form.
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Valofane is a sedative drug structurally related to the barbiturates and similar drugs such as primidone. It is metabolized once inside the body to form the barbiturate proxibarbital (proxibarbal) and is thus a prodrug.
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Although researchers are calling for further studies to be carried out, current research indicates that oral midazolam is a useful sedative drug for pediatric patients. Nitrous oxide inhalation has also proven to be useful method to treat anxious children.
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Triclofos is a sedative drug used rarely for treating insomnia. Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. The half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.
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The U.S. state of Florida used the drug in a death penalty procedure when Mark James Asay, 53, was executed on August 24, 2017. He became the first person in the U.S. to be executed with etomidate as one of the drugs. Etomidate replaces midazolam as the sedative. Drug companies have made it harder to buy midazolam for executions.
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This was determined to have been the cause of her death, along with ligature strangulation. The bag read "Farm Bureau Association Grass Seed, Lexington, Mass." Additionally, the hands had been bound behind her back with some sort of "bandage" in noticeably high- quality knots. An extremely large amount of a sedative drug, chlorpromazine, was found in the victim's stomach.
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U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABAA receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes. It has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects. It was developed by a team at Upjohn in the 1990s.
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Mebutamate (Capla, Dormate) is an anxiolytic and sedative drug with antihypertensive effects of the carbamate class. It has effects comparable to those of barbiturates such as secobarbital, but is only around 1/3 the potency of secobarbital as a sedative. Side effects include dizziness and headaches. Mebutamate is one of many GABAergic drugs which act via allosteric agonism of the GABAA receptor at the β-subreceptor similar to barbiturates.
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In this case, these areas were the ipsilateral cerebral hemispheres and the cerebellum. These areas are thought to have been inhibited by the site of injury through a GABA-mediated mechanism and the inhibition was modified by zolpidem which is a GABA agonist. The fact that zolpidem is a sedative drug that induces sleep in normal people but causes arousal in a MCS patient is paradoxical. The mechanisms to why this effect occurs is not entirely clear.
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4-NEMD is a potent sedative drug which acts as a selective alpha-2 adrenergic agonist. It is closely related to dexmedetomidine but is several times more potent. Like other alpha-2 agonists, it produces sedative and muscle relaxant effects but without producing respiratory depression. It is not currently used in medicine but has been researched as the basis for a potential new generation of alpha-2 agonist drugs, which may have selectivity for the different subtypes of the alpha-2 receptor.
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On March 3, 2016, less than 48 hours after McClendon was charged, the Justice Department filed motions and dismissed McClendon's indictment. On June 8, 2016, the Oklahoma medical examiner officially ruled the crash which killed shale pioneer McClendon was an accident. According to the autopsy report, no alcohol was involved in the accident, but an unspecified amount of the over the counter first-generation antihistamine and short-term sedative drug Doxylamine (which is used as an antihistamine or to treat insomnia) was found in Mr. McClendon's system.
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Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. It can lead to cardiac failure, rhabdomyolysis, metabolic acidosis, and kidney failure, and is often fatal. High blood potassium, high blood triglycerides, and liver enlargement, proposed to be caused by either "a direct mitochondrial respiratory chain inhibition or impaired mitochondrial fatty acid metabolism" are also key features. It is associated with high doses and long-term use of propofol (> 4 mg/kg/h for more than 24 hours).
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Acecarbromal (INN) (brand names Sedamyl, Abasin, Carbased, Paxarel, Sedacetyl, numerous others), also known as acetylcarbromal and acetyladalin, is a hypnotic and sedative drug of the ureide (acylurea) group discovered by Bayer in 1917 that was formerly marketed in the United States and Europe. It is also used in combination with extract of quebracho and vitamin E as a treatment for erectile dysfunction under the brand name Afrodor in Europe. Acecarbromal is structurally related to the barbiturates, which are basically cyclized ureas. Prolonged use is not recommended as it can cause bromine poisoning.
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Methaqualone was first synthesized in India in 1951 by Indra Kishore Kacker and Syed Husain Zaheer, for use as an antimalarial medication. By 1965, it was the most commonly prescribed sedative in Britain, where it has been sold legally under the names Malsed, Malsedin, and Renoval. In 1965, a methaqualone/antihistamine combination was sold as the sedative drug Mandrax in Europe, by Roussel Laboratories (now part of Sanofi S.A.). In 1972, it was the sixth-bestselling sedative in the US, where it was legal under the brand name Quaalude.
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ROD-188 is a sedative drug that was structurally derived from the GABAA antagonist bicuculline by a team at Roche.US Patent 6649626 N-substituted 1-(lactone) isoquinolones for treating nervous disorders Unlike bicuculline, ROD-188 acts as an agonist at GABAA receptors, being a positive allosteric modulator acting at a novel binding site distinct from those of benzodiazepines, barbiturates or muscimol, with its strongest effect produced at the α6β2γ2 subtype of the GABAA receptor. ROD-188 is one of a number of related compounds acting at this novel modulatory site, some of which also act at benzodiazepine receptors.
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New Scientist (2006-01-07). Retrieved on June 1, 2011.Toxicological findings in cases of alleged DFSA in the United Kingdom over a three-year period – Journal of Clinical Forensic Medicine, Volume 12, Issue 4, August 2005, Pages 175–186 A 2009 Australian study found that of 97 instances of patients admitted to hospital believing their drinks might have been spiked, tests were unable to identify a single case where a sedative drug was likely to have been illegally placed in a drink in a pub or nightclub, with 9 plausible cases from within the study.
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Embutramide (INN, USAN, BAN) (brand name Embutane) is a potent opioid analgesic and sedative drug that is structurally related to methadone. It was developed by Hoechst A.G. in 1958 and was investigated as a general anesthetic agent, but was found to have a very narrow therapeutic window, with a 50 mg/kg dose producing effective sedation and a 75 mg/kg dose being fatal. Along with strong sedative effects, embutramide also produces respiratory depression and ventricular arrhythmia. Because of these properties, it was never adopted for medical use as an anesthetic as it was considered too dangerous for this purpose.
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Apronal (brand name Sedormid), or apronalide, also known as allylisopropylacetylurea or allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the ureide (acylurea) group synthesized in 1926 by Hoffmann-La Roche that is no longer used except in Japan (See Japanese article). Though it is not a barbiturate, apronalide is similar in structure to the barbiturates (being an open-chain carbamide instead of having a heterocyclic ring). In accordance, it is similar in action to the barbiturates, although considerably milder in comparison (formerly used as a daytime sedative at doses of 1 to 2 grams every 3 to 4 hours). Upon the finding that it caused patients to develop thrombocytopenic purpura, apronalide was withdrawn from clinical use.
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"For any of you who have ever lain awake at night asking: Where, oh where is the statistical center of New Jersey, there really is an answer. Nenninger Lane, East Brunswick.... Over the last several decades, New Jersey’s statistical center has gradually crept its way south and west along the New Jersey Turnpike as growth in the southern and western portions of the state has outpaced the north.... Ten years ago, it was at an intersection in Milltown, about a tenth of a mile from the Turnpike and a few paces south of a Home Depot." The groundbreaking anxiolytic and sedative drug Miltown (meprobamate) developed by Carter Products, which became available to the public in the mid-1950s, was named for the borough.via Los Angeles Times.
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Flunitrazolam or alternatively Flunazolam is a triazolobenzodiazepine (TBZD), which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug, and is a potent hypnotic and sedative drug similar to related compounds such as flunitrazepam, clonazolam and flubromazolam. It was first definitively identified and reported to the EMCDDA Early Warning System, by an analytical laboratory in Germany in October 2016,Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA and had not been described in the scientific or patent literature before this. It is the triazole analogue of Flunitrazepam (Rohypnol). The addition of the triazole ring to the scaffold increases potency tremendously, this is evident as flunitrazolam is reported anecdotally to be active in the microgram level.
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Brimble, a 42-year-old mother of three from Brisbane, died within 24 hours of boarding the P&O; Cruises cruise ship Pacific Sky on 23 September 2002, apparently due to ingesting a combination of alcohol and an overdose of the drug gamma-hydroxybutyrate, otherwise known as "GHB" or "fantasy". According to news reports, security staff on the cruise ship were initially told Brimble had died of a heart attack, but there were suspicious circumstances. Toxicology reports later revealed that the amount of the sedative drug in her system was three times the amount that a recreational user would have used. Her body was found on the floor of cabin D182, which belonged to four of the men whom she had met at the ship's disco the previous night.
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QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects. QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors. The α5 subtype (and to a lesser extent the α1 subtype) of GABAA are two of the most important targets in the brain that produce the effects of alcohol, and so one of the purposes for which QH- ii-066 was developed was to reproduce the GABAergic effects of alcohol separately from its other actions.
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In medicine, specifically in end-of-life care, palliative sedation (also known as terminal sedation, continuous deep sedation, or sedation for intractable distress of a dying patient) is the palliative practice of relieving distress in a terminally ill person in the last hours or days of a dying person's life, usually by means of a continuous intravenous or subcutaneous infusion of a sedative drug, or by means of a specialized catheter designed to provide comfortable and discreet administration of ongoing medications via the rectal route. As of 2013, approximately tens of millions of people a year were unable to resolve their needs of physical, psychological, or spiritual suffering at their time of death. Considering the amount of intolerable pain the person must face, palliative care if necessary, palliative sedation can provide a more peaceful and ethical solution for such people. Palliative sedation is an option of last resort for the people whose symptoms cannot be controlled by any other means.
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