155 Sentences With "respond to treatment" | Random Sentence Generator

We know that people with mental illness respond to treatment.

"After you're diagnosed, you'll never know how you'll respond to treatment," he said.

Hopefully my wrist will respond to treatment and I'll be ready for my next start.

" There are, as Fitch acknowledges, "people who don't respond to treatment or who refuse treatment.

It may take patients who get treated later in the infection longer to respond to treatment.

Nearly 16 million adults have major depression, and up to a third do not respond to treatment.

Their cancers didn't respond to treatment, or they did but later popped back up as metastatic recurrences.

Once there, his heart was too damaged to respond to treatment and he died four days later.

Poor impulse control, substance abuse and the habit of picking anti-social friends can all respond to treatment.

With Watson's help, doctors are able to greatly improve how well patients respond to treatment and how long they live.

The Deseret News reported that Adriana Aviles was diagnosed with leukemia about three years ago and did not respond to treatment.

"Older people tend not to respond to treatment as well, but here we see 70-year-olds recovering substantially," Steinberg added.

The numbers in Bawdie who failed to respond to treatment meant there must be more to this than TB, Sarpong concluded.

In 2015 5% of the world's 10m cases failed to respond to treatment with isoniazid and rifampicin, the drugs of first resort.

The phenomenon isn't well studied, but psychiatrists believe there are several reasons why depression in older adults may not respond to treatment.

There's little proof codeine is effective for kids' coughs, and mounting evidence suggests that some children may not respond to treatment for pain.

Researchers are still working to understand why some respond to treatment and some don't so they can help the treatments benefit more people.

Instead, it leaves the patient with a small amount of cells that will still respond to treatment, which keeps the tumor responsive to therapy.

They're betting that the latest genetic screening technology is sufficiently advanced to find genetic differences that could predict how people will respond to treatment.

The idea is to write down mathematical equations that describe how tumors grow and respond to treatment in terms of established biology and physics.

These precautions are for infants with severe eczema that doesn't respond to treatment with moisturizer or corticosteroid creams or ointments, not babies with temporary rashes.

These changes can mean the difference between catching a cancer when it's very treatable versus when it's extremely advanced and unlikely to respond to treatment.

The Denver Broncos will be without cornerback Aqib Talib for the second consecutive game as his back injury continues to fail to respond to treatment.

The study, ASPIRE, tested Kyprolis, chemically known as carfilzomib, in multiple myeloma patients whose cancer had relapsed following prior treatment or did not respond to treatment.

According to BASHH, antibiotic resistance rates for the US are similar to those in the UK: 40 to 50 percent of infections don't initially respond to treatment.

Many patients respond to treatment with anti depressants and cognitive behavioral therapy, but around 20 percent don't get better and are classed as having treatment-resistant depression.

Moore says it's crucial to get these cancers tested for HPV, because he and others have been learning how differently HPV-related oropharyngeal cancers respond to treatment.

What these medical test companies haven't been able to pinpoint exactly is where a cancer is growing, how serious a threat it is, and whether it will respond to treatment.

The DEA could also reclassify CBD, but leave cannabis itself at Schedule I. Epidiolex treats two forms of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome, which rarely respond to treatment.

That may have something to do with the stresses associated with being poor in America, which may affect a person's ability to heal or respond to treatment, the researcher speculated.

After a trip to her doctor, she was diagnosed with alopecia and told there was only a 30% chance she would respond to treatment — and her insurance wouldn't cover it.

"I was very interested in collaborating with people here at Duke who could offer medical approaches that could enhance neuroplasticity, or the brain's ability to respond to treatment," Dawson says.

"The silver lining is that although women are at highest risk for mental illness during their reproductive years, they also respond to treatment better than at any other time," says White.

The stakes of belief are high in the case of Lyme, because the longer it is left undiagnosed the less likely it will respond to treatment (usually oral or I.V. antibiotics).

Courtney, a biomedical researcher, laughs at the idea of being Julian's manic pixie dream girl, because she has cyclical depression that doesn't respond to treatment and is about to enter another cycle.

The man had been breathing in these fungi every day when he played, triggering his HP.Alas, the man did not respond to treatment and died from all the damage to his lungs.

This challenge will only increase as we learn more about how individuals respond to treatment, leverage this knowledge through improved electronic health data, and enter an era of truly personalized cancer care.

"It can offer benefits that range from improvement in energy, reduction in pain, lowering of stress levels, improvement in mood, and perhaps even enhance the body's ability to respond to treatment," Dr. Saksena says.

Migraines are hell and researchers are looking into a new solution: Ketamine, the hallucinogen-turned-club-drug-turned antidepressant, may also help alleviate the crippling headaches for people who otherwise don't respond to treatment.

A 287 law requires that all medical research conducted or paid for by the National Institutes of Health include enough minorities and women to determine whether they respond to treatment differently than other groups.

Researchers are trying to narrow down the reasons why some patients with aggressive lymphoma cancers respond to treatment better than others — and a new study indicates it has to do with subtypes of tumor genes.

"Merck will not have a problem finding a partner with this data set," said Bernstein analyst Wimal Kapadia, adding that competing immunotherapies have shown a percentage of patients that respond to treatment of 15-20 percent.

The study is an early step to more fully understanding the disorder, but identifying the molecular underpinnings could explain why some patients respond to treatment while others don't, as well as point the way to new therapies.

" But in an email to Recode, Griffin emphasizes that AI still provides an important advantage: The technology can "help our scientists uncover relationships between diseases and symptoms, drugs and their effect, the patients who might respond to treatment.

It could be that women are less likely to have cardiac arrests that respond to treatment with a defibrillator and less likely to have cardiac arrests in the presence of other people who can call for help, the authors suggest.

A typical staph infection resembles a pus-filled bug bite and when it goes untreated or patients don't respond to treatment it can cause complications like pneumonia, severe organ damage and death if it enters the bloodstream, bones or organs.

Responses were similar even among patients with the worst prognosis, including those whose cancer had spread to the liver, patients who had received three or more previous therapies and those who did not respond to treatment with an immuno-oncology drug, such as Merck & Co's Keytruda, researchers reported.

People who are clinically depressed generally do respond to treatment, but often for treatment to succeed the patient has to believe in it and stick with it — and often shop around for better care — which is a snap until you get to the part about it being an illness whose key symptoms include hopelessness and inertia.

Some people who successfully respond to treatment also undergo stem cell transplantation to consolidate the response.

IBM is often confused with (misdiagnosed as) polymyositis. Polymyositis that does not respond to treatment is likely IBM.When myositis doesn't respond to treatment Retrieved 20 April 2015. Dermatomyositis shares a number of similar physical symptoms and histopathological traits as polymyositis, but exhibits a skin rash not seen in polymyositis or sIBM.

Ciclosporin has also been used in people with acute severe ulcerative colitis and hives that do not respond to treatment with steroids.

This species is not well known in cultivation but may respond to treatment similar to that for the closely related members of the family Ericaceae.

It was reported that the colt was suffering from "leg stiffness" which did not respond to treatment. Dante never ran again and was retired to stud.

The basis of management is to find and correct the underlying cause. Many times cats with EGC will respond to treatment with corticosteroids or to ciclosporin.

Some fibroadenomas respond to treatment with ormeloxifene. Fibroadenomas have not been shown to recur following complete excision or transform into phyllodes tumours following partial or incomplete excision.

She again finished unplaced and was found to have split the pastern of her right foreleg. The injury did not respond to treatment and she was euthanised later that month.

The injury did not respond to treatment, and the stallion had to be euthanized. James Brantley insisted on putting Roan Allen down himself, even though several others offered to perform the duty.

Most S. suis strains respond to treatment with ampicillin and amoxicillin. Anti-inflammatories should also be used. Control relies on good husbandry and biosecurity protocols and appropriate disinfection. Vaccines exist but are not reliable.

After playing only four games in 1949 due to the knee injury suffered in 1948, Lock retired in the 1950 pre-season when he found out the knee was "not likely to respond to treatment".

When the lesion is excised, recurrence often occurs. Palliative care with nonsteroidal anti-inflammatory drugs (NSAIDs) may be used, and topical steroids can be curative. If the lesion does not respond to treatment, biopsy is required.

As not all cases of ring chromosome 20 syndrome are the same, different individuals may respond to treatment in different ways.Alternates to antiepileptic drug treatment include the ketogenic diet and vagus nerve stimulation but not epilepsy surgery.

Cancers that do not respond to treatment with mercaptopurine do not respond to thioguanine. On the other hand, some cases of IBD that are resistant to mercaptopurine (or its pro-drug azathioprine) may be responsive to thioguanine.

Refractory anemia, an anemia which does not respond to treatment, is often seen secondary to myelodysplastic syndromes. Iron deficiency anemia may also be refractory as a manifestation of gastrointestinal problems which disrupt iron absorption or cause occult bleeding.

Roman Brother sustained an injury to his left ankle in the race, which forced him to miss an intended run in the Widener Handicap. The injury did not respond to treatment, and Roman Brother was retired from racing.

The injury did not respond to treatment and he was euthanized on 24 December. He was buried at the Woodlands Stud. At the time of his death his stud fee for 2004 had already been set at €50,000.

When Danny doesn't respond to treatment, Sam has to look for a bone marrow donor; she ends up finding a match in Derek Wells (who is actually Julian Jerome). Julian gives a bone marrow transplant, saving Danny's life.

465 OPS. Thatcher's shoulder again gave him trouble in spring training of , and he again began the season on the disabled list. But the shoulder did not respond to treatment and he was forced to undergo surgery in May.

Hunter, pp. 99–100 This time, he had developed a bowed tendon. It did not respond to treatment, and this ended his racing career. Northern Dancer was named the Champion Three-Year-Old Colt of 1964 in the United States.

Exchange blood transfusion is used to treat a rapidly rising bilirubin that does not respond to treatment with phototherapy or intravenous immunoglobulin. This is usually due to hemolytic disease of the newborn, but may also be due to other causes, e.g., G6PD deficiency.

Anti-inflammatory drugs, such as salicylates, mesalazine, and systemic corticosteroids may be prescribed for people who do not respond to other drug treatment. The long-term prognosis for this disease is good with a proportion of people suffering relapses which respond to treatment.

The prognosis is good for dogs with acute ehrlichiosis. For dogs that have reached the chronic stage of the disease, the prognosis is guarded. When bone marrow suppression occurs and there are low levels of blood cells, the animal may not respond to treatment.

Wolfsohn was diagnosed with Shell Shock, but did not respond to treatment. He subsequently cured himself by vocalizing extreme sounds, bringing about what he described as a combination of catharsis and exorcism.Newham, P. The Prophet of Song: The Life and Work of Alfred Wolfsohn. London 1997.

The treatment protocol requires once-a-week treatments for 12 weeks, 30 minutes per session. Many patients begin to see improvements by the 6th treatment. Patients who respond to treatment may require occasional treatments (~ once every 3 weeks) to sustain improvements. PTNS is a low-risk procedure.

Mammograms or breast biopsies are normally performed on women who do not respond to treatment or on non-breastfeeding women. This type of tests is sometimes ordered to exclude the possibility of a rare type of breast cancer which causes symptoms similar to those of mastitis.

There is no cure for most tremors. The appropriate treatment depends on accurate diagnosis of the cause. Some tremors respond to treatment of the underlying condition. For example, in some cases of psychogenic tremor, treating the patient's underlying psychological problem may cause the tremor to disappear.

The current (2014) listing now runs A though to J. Several subtypes are also recognised. There are at least 24 subtypes. Different genotypes may respond to treatment in different ways. ;Individual genotypes Type F which diverges from the other genomes by 14% is the most divergent type known.

Trichobezoars do not respond to treatment with Coca- Cola but instead this type may have to be surgically removed. Persimmon diospyrobezoars sometimes are resistant to Coca-Cola and require a different treatment. This can include endoscopic fragmentation and/or surgical approaches especially in urgent cases where the patient exhibits gastrointestinal bleeding.

Trichosporon asteroides is an asexual Basidiomycetous fungus first described from human skin but is now mainly isolated from blood and urine. T. asteroides is a hyphal fungus with a characteristically yeast-like appearance due to the presence of slimy arthroconidia. Infections by this species usually respond to treatment with azoles and amphotericin B.

This initiative is designed to provide clinicians with better data about how an individual patient may respond to treatment. The company also signed a Cooperative Research and Development Agreement (CRADA) with the U.S. Food and Drug Administration to advance and qualify its Human Emulation System to meet regulatory evaluation for product testing.

Rimbaud's grave in Charleville. The inscription reads Priez pour lui ("Pray for him"). In February 1891, in Aden, Rimbaud developed what he initially thought was arthritis in his right knee. It failed to respond to treatment, and by March had become so painful that he prepared to return to France for better treatment.

When CAP does not respond to treatment, this may indicate a previously unknown health problem, a treatment complication, inappropriate antibiotics for the causative organism, a previously unsuspected microorganism (such as tuberculosis) or a condition mimicking CAP (such as granuloma with polyangiitis). Additional tests include X-ray computed tomography, bronchoscopy or lung biopsy.

In addition, some groups of women respond to treatment based upon ethnicity, age, number of sexual partners, pregnancy, and the pathogens causing bacterial vaginosis. In 2013, researchers found that administration of hydrogen peroxide-producing strains, such as L. acidophilus and L. rhamnosus, were able to normalize vaginal pH and rebalance the vaginal microbiota, preventing and alleviating bacterial vaginosis.

He diagnoses her with an infection, but she does not respond to treatment and her organs begin to fail. John and Roxanna take Fiona to theatre and Roxanna concludes that the implant needs to be removed. John refuses but takes a sample from the implant. He later discovers that the implant caused the infection, but does not tell anyone.

Almutawakel finished his career with a 4-4-1 in 19 career starts. Overall, he accumulated $3,643,021 in earnings. In 2007, after failing to respond to treatment for chronic arthritis, Almutawakel was euthanized in Ireland at H.H. Sheikh Hamdan's Derrinstown Stud. At the time his death, Almutawakel sired eight stakes winners for a grand total of $5,765,852 in earnings.

Many patients do not respond to treatment with Adalimumab or lose response during treatment. A biosensor for Adalimumab could detect this at an early stage and help save unnecessary costs. Worldwide annual sales of Adalimumab are more than 10 billion US dollars. The finals of SensUs 2019 took place on the 30th of August 2019 in Eindhoven, the Netherlands.

Tiffen's work focuses on melanoma, and why some melanomas respond to treatment in certain individuals but others do not. Tiffen co-authored a study in 2016 which identified a drug that could be effective in fighting melanoma, and is currently researching a new treatment strategy with Dr. Hsin- Yi Tseng that involves inducing melanoma cellular self-destruction.

The skin lesions of HHT can be disfiguring, and may respond to treatment with long-pulsed Nd:YAG laser. Skin lesions in the fingertips may sometimes bleed and cause pain. Skin grafting is occasionally needed to treat this problem. With regards to digestive tract lesions, mild bleeding and mild resultant anemia is treated with iron supplementation, and no specific treatment is administered.

In addition, the metabolic profile of an individual at baseline (metabotype) provides information about how individuals respond to treatment and highlights heterogeneity within a disease state. All three approaches require the quantification of metabolites found in bodily fluids and tissue, such as blood or urine, and can be used in the assessment of pharmaceutical treatment options for numerous disease states.

Diagnosis is through the elimination of other causes of infectious diseases with related symptoms like ehrlichiosis and anaplasmosis or if the patient fails to respond to treatment with the antibiotic doxycycline. RT-PCR may then be used to detect viral ssRNA in the blood. Antibody titers against the virus may also be used to indicate infection with the Heartland virus.

The children retained the ability to respond to treatment with active growth hormone. The speculation of Kowarski et al. was confirmed by Valenta et al in 1985, Takahshi et al in 1996 and 1997 and Besson et al in 2005. Valenta et al studied a case of Kowarski syndrome where they confirmed a structural abnormality of the growth hormone molecule.

A test measuring a person's skin sensitivity during a migraine may indicate whether the individual will respond to treatment with triptans. Triptans are most effective in those with no skin sensitivity; with skin sensitivity, it is best to take triptans within twenty minutes of the headache's onset. Oral rizatriptan and nasal zolmitriptan are the most used triptans for migraines in children.

Roth slumped with the Red Sox, and after the season, he was traded by the Senators to the New York Yankees for Duffy Lewis and George Mogridge. Roth missed a substantial portion of the 1921 season with a knee injury. Before the 1922 season, Roth declared his knee fit for play, but the Yankees released him due to his knee injury, which did not respond to treatment.

Hypoglycemia due to hormone deficiencies such as hypopituitarism or adrenal insufficiency usually ceases when the appropriate hormone is replaced. Hypoglycemia due to dumping syndrome and other postsurgical conditions is best dealt with by altering diet. Including fat and protein with carbohydrates may slow digestion and reduce early insulin secretion. Some forms of this respond to treatment with an alpha-glucosidase inhibitor, which slows starch digestion.

Resection of the tumor is the ideal treatment and results in correction of hypophosphatemia (and low calcitriol levels) within hours of resection. Resolution of skeletal abnormalities may take many months. If the tumor cannot be located, treatment with calcitriol (1-3 µg/day) and phosphorus (1-4 g/day in divided doses) is instituted. Tumors which secrete somatostatin receptors may respond to treatment with octreotide.

After anesthetizing the eye with medication, the conjunctiva may be moved with a cotton swab to observe the location of the enlarged blood vessels. In very rare cases, if episcleritis does not respond to treatment, then a biopsy may be considered, which help provide information regarding any underlying condition (granulomatosis with polyangitis, vasculitis, etc). However, a biopsy is not routinely necessary in the diagnosis of episcleritis.

In 1987, Robinson had set a world record of 16 days, 23 hours and 9 minutes for 1000 miles, at a stage race in England. Now, more than ten years later, at Nanango, Australia, in 1998, Robinson completed the distance in a world best of 13 days, 1 hour 54 minutes. Robinson's career came to an end in 2001, when a persistent foot injury failed to respond to treatment.

It is surprising that although trastuzumab has great affinity for HER2 and high doses can be administered (because of its low toxicity), 70% of HER2+ patients do not respond to treatment. In fact resistance to the treatment develops rapidly, in virtually all patients. A mechanism of resistance involves failure to downregulate p27 (Kip1) as well as suppressing p27 translocation to the nucleus in breast cancer, enabling cdk2 to induce cell proliferation.

If the tonsillitis is caused by group A streptococcus, then antibiotics are useful, with penicillin or amoxicillin being primary choices. Cephalosporins and macrolides are considered good alternatives to penicillin in the acute setting. A macrolide such as azithromycin or erythromycin is used for people allergic to penicillin. Individuals who fail penicillin therapy may respond to treatment effective against beta-lactamase producing bacteria such as clindamycin or amoxicillin-clavulanate.

17, pp. 1-14. These refractory cases, or negative responders, account for approximately 15% of all treatment cases when a BHOM system is not used. A well designed BHOM system can reduce the population of negative responders to less than 5%, increasing the effectiveness of psychotherapy by at least 10%. Since clinicians, on their own, are abysmal at predicating what patients will negatively respond to treatment,Hannan, C., et al.

Differential expression of QSER1 is seen in multiple cancer conditions. Overexpression of QSER1 was noted in Burkitt’s Lymphoma. QSER1 expression also increases with increasing Gleason score (more advanced stages) of prostate cancer. In a study on breast cancer response to paclitaxel and fluorouracil‐doxorubicin‐cyclophosphamide chemotherapy, it was noted that breast cancer lines with higher levels of QSER1 were more likely to respond to treatment than those with underexpression of QSER1.

Patients who get better and then get worse again should likewise be questioned very closely about adherence to treatment. If adherence is confirmed then they should be investigated for resistant TB (including MDR-TB), even if a specimen has already been obtained for microbiology before commencing treatment. Prescription or dispensing errors will account for a proportion of patients who fail to respond to treatment. Immune defects are a rare cause of non-response.

She was also considered for the Prix de l'Opéra but was instead given a rest in preparation for a four-year- old campaign. She was named the Cartier Champion Three-year-old Filly of 2007. O'Brien originally planned to race Peeping Fawn in 2008 but she did not impress in training. After a June exercise gallop, she sustained a minor injury and was retired in August when she failed to respond to treatment.

The few contraindications to surgery include inoperable tumor, massive obesity, a particularly high-risk operation, or a desire to preserve fertility. These contraindications happen in about 5–10% of cases. Women who wish to preserve their fertility and have low-grade stage I cancer can be treated with progestins, with or without concurrent tamoxifen therapy. This therapy can be continued until the cancer does not respond to treatment or until childbearing is done.

Psychopaths may have a markedly distorted sense of the potential consequences of their actions, not only for others, but also for themselves. They do not, for example, deeply recognize the risk of being caught, disbelieved or injured as a result of their behaviour. However, numerous studies and recent large- scale meta-analysis cast serious doubt on claims made about the ability of psychopathy ratings to predict who will offend or respond to treatment.

These processes are dependent on cytokines like interferon alpha or beta, interferon gamma or interleukin 27. As mentioned above, low levels of interleukin 17A were observed, therefore impaired the Th17 polarization of the immune response. Patients with STAT1 gain of function mutation and CMC poorly or not at all respond to treatment with azole drugs such as Fluconazole, Itraconazole or Posaconazole. Besides common viral and bacterial infections, these patients develop autoimmunities or even carcinomas.

Stump became seriously ill in 2005, so much so that euthanasia was considered. Stump was initially taken to the Brittmoore Animal Hospital in Houston, but he did not respond to treatment there. In January 2006, he was transferred to Texas A&M; University's Small Animal Hospital for treatment by veterinary specialists. Stump was hospitalized for a total of 19 days, including 12 in the intensive care unit of A&M;'s Small Animal Hospital.

Significant central nervous system depression is treated within a hospital setting by maintaining breathing and circulation. Individuals with reduced breathing may be given supplemental oxygen, while individuals who are not breathing can be ventilated with bag valve mask ventilation or by mechanical ventilation with a respirator. Sympathomimetic drugs may be used to attempt to stimulate cardiac output in order to maintain circulation. Central nervous system depression caused by certain drugs may respond to treatment with an antidote.

Taken to a hospital in Ramallah after she choked on the gas, she did not respond to treatment and died the following day. Members of the Israeli military (IDF) claimed there was no evidence Rahma participated in the protest, or that tear gas had killed her, and stated that there were irregularities in the Palestinian Authority's medical report on Rahma's death.IDF: No proof Palestinian woman died from tear gas at protest, haaretz.com; accessed 27 January 2016.

Mobitz I is characterized by a progressive, yet, reversible block of the AV node. On ECG, this is defined by a progressive prolongation of the PR interval, with a resulting dropped beat (the PR interval gets longer and longer until a beat is finally dropped, or skipped). Some patients are asymptomatic; those who have symptoms respond to treatment effectively. There is low risk of a Mobitz I AV block leading to heart attack and complete heart block.

Diagnosis is fourfold: History and physical examination, elevation of creatine kinase, electromyograph (EMG) alteration, and a positive muscle biopsy. The hallmark clinical feature of polymyositis is proximal muscle weakness, with less important findings being muscle pain and dysphagia. Cardiac and pulmonary findings will be present in approximately 25% of cases of patients with polymyositis. Sporadic inclusion body myositis (sIBM): IBM is often confused with (misdiagnosed as) polymyositis or dermatomyositis that does not respond to treatment is likely IBM.

Viral meningitis typically only requires supportive therapy; most viruses responsible for causing meningitis are not amenable to specific treatment. Viral meningitis tends to run a more benign course than bacterial meningitis. Herpes simplex virus and varicella zoster virus may respond to treatment with antiviral drugs such as aciclovir, but there are no clinical trials that have specifically addressed whether this treatment is effective. Mild cases of viral meningitis can be treated at home with conservative measures such as fluid, bedrest, and analgesics.

On 7 June, Midway Lady started 15/8 favourite for the Epsom Oaks. Ridden again by Cochrane, she won by a length from Untold with Maysoon third. Her winning time of 2:35.60 was more than one and a half seconds faster than that recorded by Shahrastani, when beating Dancing Brave in the Derby over the same course and distance three days earlier. After the Oaks, Midway Lady sustained a leg injury described as inflamed tendon sheath, which did not respond to treatment.

Many antibiotics are frequently prescribed to treat symptoms or diseases that do not respond to antibiotics or that are likely to resolve without treatment. Also, incorrect or suboptimal antibiotics are prescribed for certain bacterial infections. The overuse of antibiotics, like penicillin and erythromycin, has been associated with emerging antibiotic resistance since the 1950s. Widespread usage of antibiotics in hospitals has also been associated with increases in bacterial strains and species that no longer respond to treatment with the most common antibiotics.

The key difference between OCD and post-traumatic stress disorder (PTSD) is that the intrusive thoughts of PTSD sufferers are of content relating to traumatic events that actually happened to them, whereas OCD sufferers have thoughts of imagined catastrophes. PTSD patients with intrusive thoughts have to sort out violent, sexual, or blasphemous thoughts from memories of traumatic experiences.Baer (2001), pp. 62–64 When patients with intrusive thoughts do not respond to treatment, physicians may suspect past physical, emotional, or sexual abuse.

SSRIs are efficacious in the treatment of OCD; people treated with SSRIs are about twice as likely to respond to treatment as those treated with placebo. Efficacy has been demonstrated both in short-term (6–24 weeks) treatment trials and in discontinuation trials with durations of 28–52 weeks. In 2006, the National Institute of Clinical and Health Excellence (NICE) guidelines recommended antipsychotics for OCD that does not improve with SSRI treatment. For OCD there is tentative evidence for risperidone and insufficient evidence for olanzapine.

CTD is difficult to treat because the actual transporter responsible for transporting creatine to the brain and muscles is defective. Affected individuals have sufficient amounts of creatine, however it cannot get to the tissues where it is needed. Studies in which oral creatine monohydrate supplements were given to patients with CTD found that patients did not respond to treatment. However, similar studies conducted in which patients that had GAMT or AGAT deficiency were given oral creatine monohydrate supplements found that patient’s clinical symptoms improved.

They are typically divided into low and high grade, typically corresponding to indolent (slow-growing) lymphomas and aggressive lymphomas, respectively. As a generalisation, indolent lymphomas respond to treatment and are kept under control (in remission) with long-term survival of many years, but are not cured. Aggressive lymphomas usually require intensive treatments, with some having a good prospect for a permanent cure.Merck Manual home edition, Non-Hodgkin Lymphomas Prognosis and treatment depends on the specific type of lymphoma as well as the stage and grade.

Approximately 20 randomized controlled trials and numerous observational studies indicate that cognitive behavioral therapy (CBT) is an effective treatment for hypochondriasis. Typically, about two- thirds of patients respond to treatment, and about 50% of patients achieve remission, i.e., no longer suffer from hypochondriasis after treatment. CBT for hypochondriasis and health anxiety may be offered in various formats, including as face-to-face individual or group therapy, via telephone, or as guided self-help with information conveyed via a self-help book or online treatment platform.

The top-line results from the study were presented at the ESMO 2017 congress and right after that, it was published in the Lancet journal in September 2017. The findings showed significant improvement in progression- free survival (PFS) in patients treated with Rubraca than placebo. Recently, in October 2017, a supplemental sNDA for the rucaparib ARIEL3 maintenance treatment has been submitted to the FDA. The ARIEL4 trial is still ongoing to evaluate how patients will best respond to treatment with rucaparib compared with chemotherapy.

Patients are said to relapse if they improve while on treatment, but become ill again after stopping treatment. Patients who experience only a transient improvement while on treatment, or who never respond to treatment are said to have failed treatment and are discussed above. There is a small relapse rate associated with all treatment regimens, even if the treatment has been taken religiously with 100% compliance (the standard regimen 2HREZ/4HR has a relapse rate of 2 to 3% under trial conditions). The majority of relapses occur within 6 months of finishing treatment.

Dietary changes, such as maintaining a high-calorie diet or lactose-free diet, may improve symptoms. Several medications are used to treat symptoms and bring about and maintain remission, including aminosalicylates such as mesalazine or sulfasalazine, steroids, immunosuppressants such as azathioprine, and biologic therapy. Removal of the colon by surgery may be necessary if the disease is severe, does not respond to treatment, or if complications such as colon cancer develop. Removal of the colon and rectum generally cures the condition. Together with Crohn's disease, about 11.2 million people were affected .

He was placed on the disabled list on July 16 with a sore back. When his injury did not respond to treatment, he underwent an X-Ray which revealed that he had multiple fractures in his back, which kept him out of action for the rest of the season. After recovering from his injuries, Thompson was optioned to the Oklahoma City Dodgers to begin the 2017 season, but was called up to the parent club partway through the season. Ultimately, he played in 95 games for the Oklahoma City club and 27 for the Dodgers.

Severe congenital neutropenia (SCN), also often known as Kostmann syndrome or disease, is a group of rare disorders that affect myelopoiesis, causing a congenital form of neutropenia, usually without other physical malformations. SCN manifests in infancy with life-threatening bacterial infections. Most cases of SCN respond to treatment with granulocyte colony-stimulating factor (filgrastim), which increases the neutrophil count and decreases the severity and frequency of infections. Although this treatment has significantly improved survival, people with SCN are at risk of long-term complications such as hematopoietic clonal disorders (myelodysplastic syndrome, acute myeloid leukemia).

Moore and her husband both became followers of the Subud spiritual movement and also both changed their names, eventually being known as Phillip and Deborah Bentin. In the 1960s, an eye infection which did not respond to treatment led to Moore becoming blind and ended her artistic career. Moore wrote an unpublished autobiography and gave oral history interviews to both the academic Gill Clarke and the Imperial War Museum. Paintings by Moore are held by the Imperial War Museum, IWM, the Victoria and Albert Museum and the British Museum.

In May 2020, he was chosen as one of two Nova Scotia experts, along with Emily Marshall, to receive grant funding from the Canadian Institutes of Health Research and Research Nova Scotia as part of a Rapid Research Funding Opportunity. Uher's funding will support his research on the mental health effects of the COVID-19 pandemic, which specifically focuses on parents with preexisting mental illnesses. In June 2020, a study he led reported that individuals with depression who did not respond to the commonly used serotonergic antidepressant escitalopram did respond to treatment with aripiprazole.

Bleeding time is usually prolonged in ITP patients. However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines and a normal bleeding time does not exclude a platelet disorder. Bone marrow examination may be performed on patients over the age of 60 and those who do not respond to treatment, or when the diagnosis is in doubt. On examination of the marrow, an increase in the production of megakaryocytes may be observed and may help in establishing a diagnosis of ITP.

It is not until the supposed uveitis fails to respond to treatment, becomes recalcitrant to treatment, or shows worsening with discontinuation of corticosteroid treatment that another cause is sought out. If PIOL is suspected, it is important to first obtain a magnetic resonance image (MRI) of the brain to rule out cerebral involvement (PCNSL). If MRI is negative, lumbar puncture with cerebrospinal fluid (CSF) cytology should be performed to further rule out CNS disease. Histopathologic identification of atypical lymphocytes is considered the gold standard for diagnosing PCNSL/PIOL.

Canine chromosome 7 has been found to be most significantly associated with obsessive compulsive disorder in dogs, or more specifically, canine compulsive disorder (CCD). This breakthrough helped further relate OCD in humans to CCD in canines. Canine chromosome 7 is expressed in the hippocampus of the brain, the same area that Obsessive Compulsive Disorder is expressed in human patients. Similar pathways are involved in drug treatment responses for both humans and dogs, offering more research that the two creatures exhibit symptoms and respond to treatment in similar ways.

Lenvatinib is approved (since 2015) for the treatment of differentiated thyroid cancer that is either locally recurrent or metastatic, progressive, and did not respond to treatment with radioactive iodine (radioiodine). for Lenvima. In May 2016, the US FDA approved it (in combination with everolimus) for the treatment of advanced renal cell carcinoma following one prior anti-angiogenic therapy. The drug is also approved in the US and in Europe for hepatocellular carcinoma that cannot be removed surgically in patients who have not received cancer therapy by mouth or injection.

This study, however, was not as successful as the Parkinson's treatment. In this case stem cells were used to treat animal models who had been injured in a way that mimicked CP. This brings up a neuroethical issue of animal models used in science. Since most of their "diseases" are inflicted and do not occur naturally, they can not always be reliable examples of how a person with the actual disease would respond to treatment. The stem cells used did survive implantation, but did not show significant nerve regeneration.

In the final Ballyhennessy Seal led all the way with Rhynn Castle staying prominent throughout, Duffys Arrival and Celtic Chief impeded each other with Magic Bohemian finishing well to take third. After a short break Ballyhennessy Seal returned to action in the Laurels and progressed through the competition with ease but was then reported to be suffering from rheumatism in his hind legs. He was subsequently withdrawn because he did not respond to treatment and was then retired to stud. In 1946 he demanded £100 for a mating fee at the Burhill Kennels.

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) (topical form), allergic rhinitis (such as hay fever) (topical form), asthma (inhalation form) for patients unresponsive to less potent corticosteroids, and penile phimosis. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone. Some low-quality evidence suggests the use of mometasone for symptomatic improvement in children with adenoid hypertrophy. Mometasone is used to alleviate inflammation and itchiness in skin conditions that respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis.

House, however, bets Wilson $100 that it's actually a recurrence of his cancer, which Wilson refuses to believe. Tucker is discovered to have acute lymphoblastic leukemia, a different form of leukemia than the one he was treated for five years ago (the chemo treatment of which possibly caused/complicated this new recurrence). The cancer seems very treatable, but Tucker does not initially respond to treatment. During the treatment process, regardless of House's warning Wilson decides to employ a double dose of chemotherapy, which does cure the cancer but leads to severe liver damage.

Grubitsch "Grubbs" Grady, the younger child of chess-obsessed parents, grows increasingly uneasy with the recent strange, nervous behavior of his parents and sister. One night, he finds the mutilated bodies of his family and encounters Lord Loss, a gruesome human-like demon who sets his two familiars, Vein and Artery, on Grubbs. Although Grubbs manages to escape, he is deeply traumatized and is placed in a mental institute. He refuses to respond to treatment until he is visited by his father's younger brother, Dervish Grady, who tells Grubbs that he knows demons exist and convinces Grubbs to finally accept help.

Whilst women are more susceptible to drug addiction, the majority of addiction studies are focussed on men. This means that medication development has focussed on correcting addiction in men, and may explain why women do not respond to treatment in the same way as men. Calipari found that when hormones related to fertility are high, women make stronger associations to clues in their environment and more likely to seek rewards, which makes them more prone to drug addiction and relapse. Her research can be used by treatment centres to educate women about their decision making mechanisms.

A Marketing Authorization Application (MAA) filing for vintafolide and etarfolatide for the treatment of patients with folate receptor-positive platinum-resistant ovarian cancer in combination with doxorubicin, pegylated liposomal doxorubicin (PLD), has been accepted by the European Medicines Agency. The drug received orphan drug status in Europe in March 2012. Merck & Co. acquired the development and marketing rights to this experimental cancer drug from Endocyte in April 2012. Endocyte remains responsible for the development and commercialization of etarfolatide, a non-invasive companion imaging agent used to identify patients expressing the folate receptor that will likely respond to treatment with vintafolide.

The effects of donepezil, galantamine and rivastigmine have all been assessed but, overall, the findings have been inconsistent, and it is estimated that apathy in ~60% of Alzheimer's patients does not respond to treatment with these drugs. Methylphenidate, a dopamine and noradrenaline reuptake blocker, has received increasing interest for the treatment of apathy. Management of apathetic symptoms using methylphenidate has shown promise in randomized placebo controlled trials of Alzheimer's patients. A phase III multi-centered randomized placebo-controlled trial of methylphenidate for the treatment of apathy is currently underway and planned for completion in August 2020.

Overall, the goal of pharmacometabolomics is to more closely predict or assess the response of an individual to a pharmaceutical compound, permitting continued treatment with the right drug or dosage depending on the variations in their metabolism and ability to respond to treatment. Pharmacometabolomic analyses, through the use of a metabolomics approach, can provide a comprehensive and detailed metabolic profile or “metabolic fingerprint” for an individual patient. Such metabolic profiles can provide a complete overview of individual metabolite or pathway alterations, providing a more realistic depiction of disease phenotypes. This approach can then be applied to the prediction of response to a pharmaceutical compound by patients with a particular metabolic profile.

Catecholamines are secreted by cells in tissues of different systems of the human body, mostly by the nervous and the endocrine systems. The adrenal glands secrete certain catecholamines into the blood when the person is physically or mentally stressed and this is usually a healthy physiological response. However, acute or chronic excess of circulating catecholamines can potentially increase blood pressure and heart rate to very high levels and eventually provoke dangerous effects. Tests for fractionated plasma free metanephrines or the urine metanephrines are used to confirm or exclude certain diseases when the doctor identifies signs of hypertension and tachycardia that don't adequately respond to treatment.

EGFR-TKI's have been found to be active against variants exhibiting certain mutations in the EGFR gene. While EGFR mutations are very rare (<5%) in "pure" SCLC, they are considerably more common (about 15–20%) in c-SCLC, particularly in non-smoking females whose c-SCLC tumors contain an adenocarcinoma component. These patients are much more likely to have classical EGFR mutations in the small cell component of their tumors as well, and their tumors seem to be more likely to respond to treatment with EGFR- TKI's. EGFR-targeted agents appear particularly effective in papillary adenocarcinoma, non-mucinous bronchioloalveolar carcinoma, and adenocarcinoma with mixed subtypes.

Further lowering the group's spirits, their zoologist, Nicolai Hanson, fell ill, failed to respond to treatment, and died on 14 October 1899. When the southern winter ended and sledging activity became possible, Borchgrevink's assumptions about an easy route to the interior were shattered; the glaciated mountain ranges adjoining Cape Adare precluded any travel inland, restricting exploration to the immediate area around the cape. However, Borchgrevink's basic expedition plan—to overwinter on the Antarctic continent and carry out scientific observations there—had been achieved. When Southern Cross returned at the end of January 1900, Borchgrevink decided to abandon the camp, although there were sufficient fuel and provisions left to last another year.

There is an ongoing discussion however the term chronic enteropathy might be a better term to use than Inflammatory bowel disease in dogs because it differs from IBD in humans in how the dogs respond to treatment. For example, many dogs respond to only dietary changes compared to humans with IBD who often need immunosuppressive treatment. Some dogs may also need immunosuppressant or antibiotic treatment when dietary changes are not enough. After having excluded other diseases that can lead to vomiting, diarrhea and abdominal pain in dogs, intestinal biopsies are often performed to investigate what kind of inflammation that is occurring (lymfoplasmacytic, eosinophilic or granulomatous).

In Canada, SSRIs are a first-line treatment of adult obsessive–compulsive disorder (OCD). In the UK, they are first-line treatment only with moderate to severe functional impairment and as second line treatment for those with mild impairment, though, as of early 2019, this recommendation is being reviewed. In children, SSRIs can be considered a second line therapy in those with moderate-to-severe impairment, with close monitoring for psychiatric adverse effects. SSRIs, especially fluvoxamine, which is the first one to be FDA approved for OCD, are efficacious in its treatment; patients treated with SSRIs are about twice as likely to respond to treatment as those treated with placebo.

Studies have indicated that detection of KRAS gene mutations helps physicians identify patients that are unlikely to respond to treatment with targeted EGFR inhibitors, including cetuximab and panitumumab. Accordingly, genetic testing to confirm the absence of KRAS mutations (and so the presence of the KRAS wild-type gene), is now clinically routine before the start of treatment with EGFR inhibitors. mCRC patients with wild-type KRAS tumors have been shown to benefit from a response rate of over 60% and a decreased risk for progression of over 40% when treated with Erbitux as 1st-line therapy. Around 65% of mCRC patients have the KRAS wild-type gene.

In people managed in the community, determining the causative agent is not cost- effective and typically does not alter management. For people who do not respond to treatment, sputum culture should be considered, and culture for Mycobacterium tuberculosis should be carried out in persons with a chronic productive cough. Microbiological evaluation is also indicated in severe pneumonia, alcoholism, asplenia, immunosuppression, HIV infection, and those being empirically treated for MRSA of pseudomonas. Although positive blood culture and pleural fluid culture definitively establish the diagnosis of the type of micro-organism involved, a positive sputum culture has to be interpreted with care for the possibility of colonisation of respiratory tract.

Pebbles took the lead in the straight but was overtaken in the final furlong and beaten one and a half lengths by Katies, with the two fillies pulling well clear of their eight opponents. Brittain pointed out that the filly had been trained with the Oaks in mind and had been prepared to race over one and a half miles rather than the one mile distance. Pebbles was trained for a rematch with Katies in the Child Stakes but stood on a stone before the race and was withdrawn. The injury failed to respond to treatment and x-ray revealed a chipped bone in her foot which kept her off the course until autumn.

In addition, people of African descent are much less likely to respond to treatment when infected with genotypes 1 or 4. Erratum: The substantial proportion of this lack of response to treatment is proposed to be caused by a single-nucleotide polymorphism (SNP) on chromosome 19 of the human genome that is predictive of treatment success. HCV genotypes 1 and 4 have been distributed endemically in overlapping areas of West and Central Africa, infecting for centuries human populations carrying the genetic polymorphism in question. This has prompted scientists to suggest that the protracted persistence of HCV genotypes 1 and 4 in people of African origin is an evolutionary adaptation of HCV over many centuries to these populations’ immunogenetic responses.

The text asserts that there are four important parts to medical practice – the patient, the physician, the nurse and the medicines.MS Valiathan (2009), An Ayurvedic view of life, Current Science, Volume 96, Issue 9, pages 1186-1192 All four are essential to recovery and return to health, states the text. The physician provides knowledge and coordinates the treatment, he is who can "explore the dark interior of the body with the lamp of knowledge", according to the text and Valiathan's translation. The physician must express joy and cheer towards those who can respond to treatment, masterfully avoid and save time in cases where the patient suffers from incurable disease, while compassionate towards all.

Drug treatment of OCD may be assumed to affect a proposed functional imbalance between the frontal lobes and other parts of the brain. Serotonin reuptake inhibitors, SRI, especially potent ones given at high doses over long periods of time, are often effective in the treatment of obsessive-compulsive disorder. However, a large percentage of patients do not respond to treatment with the SRI, and those who do respond often do not fully remit, which should be the standard goal of treatment in OCD. If a patient has been treated for several months and has not yet responded to treatment with several types of SRI medication, the physician should perform a careful assessment of resistant and/or residual clinical symptoms.

Ringside physicians tried to revive Bejines, but he did not respond to treatment. He was then taken to California Hospital, from where he was airlifted to Los Angeles County-University of Southern California Medical Center, where several attempts were made at saving his life the following days, including the removal of part of his brain and skull and of a blood clot to try to diminish his brain pressure. Bejines was held on a respirator machine until he died on September 4. Bejines' death was the first in professional boxing since Kim's; it was also the first involving a boxer after a fight at the Olympic Auditorium since Johnny Owen's after his unsuccessful challenge of Pintor in 1980.

Patients who fail treatment must be distinguished from patients who relapse. Patients who responded to treatment and appeared to be cured after completing a course of TB treatment are not classed as treatment failures, but as relapses and are discussed in a separate section below. Patients are said to have failed treatment if they # fail to respond to treatment (cough and sputum production persisting throughout the whole of treatment), or # only experience a transient response to treatment (the patient gets better at first, but then get worse again, all the while on treatment). It is very uncommon for patients not to respond to TB treatment at all (even transiently), because this implies resistance at base-line to all of the drugs in the regimen.

This situation was brought home to McMillan one Sunday when he was at the ground having a bit of a kick around. McMillan got chatting to a bloke who was sweeping out the stands and it turned out he had been a player of some note and had been captain of the team. When he retired the Club had kept him on as a cleaner. Graham McMillan injured his left knee in the New Year. The treatment afforded to him by the Club was a bit of a rub and a reassuring, "you’re ok" by an unqualified ‘trainer’ in the Club’s Medical Room in which the facilities were way short of state-of-the-art. McMillan kept playing though the knee failed to respond to ‘treatment’.

It was not long before Guest was wounded, and then he fell victim to an irritating and persistent skin complaint which was common in the trenches and did not respond to treatment. He was evacuated to England and after a brief period in hospital was sent to the Imperial Hydro at St Annes, where he was told that he would not be fit to return to his unit for six months. Through a contact at the War Office, Guest had his name added to a list of officers available for special employment, and was selected to undertake a propaganda tour of the United States, delivering 160 lectures to approximately 282,000 people in total. He was then sent to France to promote the benefits of Southern Rhodesia to the large number of soldiers who had become unsettled and wished to emigrate.

A pre-existing intratumoral anti-tumor T helper (Th-1) immune response has been linked to favorable outcomes with immunotherapy, but not all immunologically active cancers respond to treatment. In a pan-cancer analysis using The Cancer Genome Atlas (TCGA) including 31 cancer types from 9282 patients, high expression of the ICR signature was associated with significant prolonged survival in breast invasive carcinoma, skin cutaneous melanoma, sarcoma, and uterine corpus endometrial carcinoma, while this "hot" immune phenotype was associated with reduced overall survival in uveal melanoma, low grade glioma, pancreatic adenocarcinoma and kidney renal clear cell carcinoma. In a systemic analysis, cancer-specific pathways were found to modulate the prognostic value of ICR. In tumors with a high proliferation score, ICR was linked to better survival, while in tumors with low proliferation no association with survival was observed.

The American Academy of Ophthalmology practice guidelines do not recommend laser coagulation therapy for macular degeneration, but said that it may be useful in people with new blood vessels in the choroid outside of the fovea who don't respond to treatment with anti- VEGF drugs. Argon, krypton, dye and diode lasers have been used with varying levels of energy have been used to try to prevent age-related macular degeneration by eliminating drusen. A Cochrane review published in 2015 found that while laser treatment reduces drusen, there is no difference from placebo at 2 years with respect to preventing vision loss. A 2007 Cochrane review on found that laser photocoagulation of new blood vessels in the choroid outside of the fovea using blue-green argon, green argon, red krypton, or near- infrared diode is effective and economical method, but that the benefits are limited for vessels next to or below the fovea.