Reata is an outlier here in that the Irving, Tex.
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" Reata Pharmaceuticals: "I got to do some work on that.
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Shares of Reata Pharmaceutical jumped more than 5% after Chen revealed her bet on the drugmaker.
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A RIATA (also seen as REATA) is a rope tied in a noose and used to rope cattle.
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Reata Pharmaceuticals (US, biotech) – $439.2m FO. 2.4m shares (100% prim) at $183.00 versus $187.48 last sale and $182.83 launch.
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Based on the positive results, Reata said it plans to go forward with seeking regulatory approval for marketing the drug both domestically and internationally.
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Bihua Chen, founder and portfolio manager at Cormorant Asset Management, said on Monday she likes Reata Pharmaceuticals for the drug it's developing to fight kidney disease.
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Reata Pharmaceuticals shares tanked nearly 8% after the bell following the company's announcement of promising test results of its drug treating patients with chronic kidney disease.
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We got this video of the singer at the Reata rooftop in Ft. Worth, and it's as clear as the booze she's no longer that Disney star Bieber grew to love.
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S. FDA has granted orphan designation to bardoxolone methyl for treatment of alport syndrome * Reata expects data from phase 2 portion of trial to be available by year-end 2017 Source text for Eikon: Further company coverage:
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In 2002, Reata opened a facility called Reata at the Rodeo, located in the Amon Carter Exhibits Hall to serve the Fort Worth Stock Show and Rodeo. In 2007, Reata took over operation of the Backstage Club at the Fort Worth Stock Show and Rodeo renaming it Reata at the Backstage Club. In the fall of 2008, a cookbook, authored by Mike Micallef, was released called "Reata: Legendary Texas Cooking". This cookbook is sold through Amazon and the Reata Store.
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The restaurant was founded by Al Micallef in Alpine, Texas in 1995. The name Reata is Spanish for Rope, which was inspired from the novel Giant, by Edna Ferber. In 1996, the Reata opened its second location in Fort Worth, Texas, on the 35th floor of the Bank One tower. Following a devastating F2 tornado on March 28, 2000, Reata was hit and forced to close.
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La Reata is housed in the Albuquerque High School library but copies can also be found online.
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La Reata is the name given to the official Albuquerque High School yearbook. Its first edition was printed in 1909. It was not until 1917 that the school began to teach printing, and in 1918 the first student-produced La Reata was printed. The 2013 edition was the 104th volume.
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Investigations of bardoxolone methyl have been conducted by Reata Pharmaceuticals in a partnership with Abbvie and Kyowa Hakko Kirin.
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Notable chefs that started their careers at the Reata include Grady Spears, Tim Love, Brian Olenjack, and Tod Phillips.
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Within 6 weeks, the restaurant was rebuilt and operational in the original location that was hit by the tornado. In January 2001 the restaurant was once again forced to close, and re-opened in May 2002 in the building that previously known as the Caravan of Dreams. In 2001 between the time Reata had to close in the Bank One Tower and Re-opening in Sundance Square, the Reata started a catering division with a 3000sq. ft. commercial kitchen called Reata on the Road.
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In January 2010, Reata opened a Mexican cuisine based Restaurant at the Fort Worth Stock Show and Rodeo. It is called La Espuela.
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Donning the name of Reata, Vanessa proves herself to be a vital member of the team, but will often place herself in danger without considering the consequences.
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The essays, originally published in Ranch & Reata magazine, are centered on the American West and include an essay on Johnny Cash for which Russell won a 2015 ASCAP AWARD for music journalism.
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There is a lot of "mixing" of opposites in this story that is a direct result of the physical and cultural setting: Catholic and Animist practice, Native American and European reminiscent of Estela Portillo Trambley’s "The Burning"in American Woman Writers: Diverse Voices in Prose Since 1845. eds. Eileen Barret and Mary Cullinan. St. Martin's, 1993. 637-644 which juxtaposes Europe versus the New World, aristocracy and peasantry, light and dark, justice and evil. The reata (or lariat) is functionally compromised when two elements are intertwined: Fray Luis’s monk’s cord and the leather from Saturnino’s reata.
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According to family legend, Reata was a nurse during World War I, working in a field hospital inside a bombed-out church in Belgium when a German shell hit. She was assisting in a surgery on a wounded soldier, and threw herself over him to keep debris out of his wounds. According to the story, they had to be pulled from the rubble, the soldier survived, and Reata received a decoration from the British government. This event brought her to the attention of an American magazine illustrator, possibly P.G. Morgan, who did 100 oil paintings for the Red Cross of her as a nurse, at night in a field hospital, using a small flashlight to read a patient's thermometer.
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A Reata-funded, Phase 2 multi-center RCT (BEAM) in patients with moderate to severe CKD and type 2 diabetes reported that eGFR was increased (> 10 ml/min/1.73 m²) in patients treated with bardoxolone methyl for 24 months. An analysis of secondary endpoints showed that approximately three-quarters of bardoxolone methyl-treated patients experienced at least a 10 percent increase in eGFR, and one-quarter of the patients had an improvement of 50%. Adverse events in bardoxolone methyl- treated patients were generally manageable and mild to moderate in severity, with muscle spasm being reported most frequently. In 2014, Reata announced the initiation of a placebo-controlled, multicenter Phase 2 study (LARIAT), to assess the effects of bardoxolone methyl in pulmonary arterial hypertension.
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The painting was supposedly made into the cover illustration of one of the era's magazines. Though there is no documentation known to exist of this tale so far, the actual oil painting does exist, and currently has a place of honor in her granddaughter's home in Waldorf, Maryland. At some point during the war Reata produced short stories and magazine articles under the pen name Reata Van Houten; this much is documented. Her stories include Honor Among Thieves, All-Story Weekly (1917); Fiddler Joe, All-Story Weekly (1919); The Seven Sleeper, All-Story Weekly (1919); and Comrades of the Trail, and Munsey’s (1927). During the 1930s, she wrote articles for Field & Stream and similar magazines on topics like fly fishing.
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Riders carrying modern lassos for competition in team roping. A loose bull is lassoed by a pickup rider during a rodeo Charro with lariat at a horse show in Pachuca, Hidalgo, Mexico Lassoing on the prairie (from the book Prairie Experiences in Handling Cattle and Sheep, by Major W. Shepherd, 1884) A lasso ( or ), also called lariat, riata, or reata (all from Castilian, la reata 're- tied rope'), is a loop of rope designed as a restraint to be thrown around a target and tightened when pulled. It is a well-known tool of the Spanish and Mexican cowboy, then adopted by the United States cowboy. The word is also a verb; to lasso is to throw the loop of rope around something.
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Nellie, the Beautiful Cloak Model is a play written by Owen Davis. A Broadway production of it by A. H. Woods opened in 1906 and was a huge hit. The story is a melodrama, and it was often cited as an archetype of the genre. Reata Winfield originated the title role in the Broadway production.
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Reata Winfield performing in the Broadway production. Nellie Grey is a young woman who works in the cloak department of a department store. She lives in a boarding house with her abusive great uncle and his handicapped son, Tom. Long separated from her mother, she is unaware that she has a fortune coming to her.
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3.2 Ruiz- Kinikilali Berenda: This handsome young son of Esteban Berenda is a half- Spanish, half-esselen vaquero. He is skilled at riding horses and throwing the reata, or lariat. He is killed by a bear who may be a medicine man in disguise. 3.3 Saturnino: El mayordomo, "a combination of sacristan and Indian chief".
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The Broadway production opened on New Year's Eve in 1906 at the West End Theatre. A. H. Woods produced and Reata Winfield played the role of Nellie. After a long run on Broadway, the play moved to road companies, where it continued to pull large audiences. A production on Manhattan's Lower East Side ran for five years.
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He says he is a Rumsen Indian, but is most likely a runaway Esselen. He is in charge of the chapel and the nunnery (where the unmarried women stay). He is a reata-maker who weaves the lariat intended to snare the bear that eventually kills Ruiz. 3.4 Fray Bernardo: Superior of the Mission San Carlos Borromeo de Carmelo.
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The Lily is a 1926 American drama film directed by Victor Schertzinger and written by Eve Unsell. It is based on the 1923 play The Lily by David Belasco. The film stars Belle Bennett, Ian Keith, Reata Hoyt, Barry Norton, John St. Polis and Richard Tucker. The film was released on October 3, 1926, by Fox Film Corporation.
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A Phase 3 multinational RCT (BEACON) designed to test the effect of bardoxolone methyl on progression to end-stage renal disease or cardiovascular death in patients with stage 4 CKD and type 2 diabetes was initiated by Reata in June 2011 and halted in October 2012 after bardoxolone methyl-treated patients were found to have experienced a higher rate of heart- related adverse events, including heart failure, hospitalizations, and deaths. A retrospective post-hoc analyses of the Phase 3 data, conducted by Reata, identified prior hospitalization for heart failure and the baseline level of brain natriuretic peptide, a marker of fluid retention, as predictors of heart failure hospitalizations in the BEACON trial. For patients without these baseline characteristics, the risk for heart failure events among bardoxolone methyl- and placebo-treated patients was similar.
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Northern Yuma County Union High School was the high school for northern Yuma County, Arizona (now La Paz County). It had branches in Parker and Salome by the mid-1950s. Both eventually were spun off into their own high schools, Parker High School and Salome High School, by the late 1950s. Parker kept the mascot, yearbook name (La Reata), and other traditions.
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Omaveloxolone (RTA 408) is a second generation member of the synthetic oleanane triterpenoid compounds and currently in clinical development by Reata Pharmaceuticals. Preclinical studies have demonstrated that omaveloxolone possesses antioxidative and anti-inflammatory activities and the ability to improve mitochondrial bioenergetics. Omaveloxolone is currently under clinical investigation for a variety of indications, including Friedreich’s ataxia, mitochondrial myopathies, immunooncology, and prevention of corneal endothelial cell loss following cataract surgery.
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Pedersen was born in Grand Island, Nebraska, the third of four children of Danish immigrants John H. and Matilda Christine Pedersen. The Pedersen family were ranchers and lived in several western states; they had a family ranch near Jackson Hole, Wyoming, where John Douglas lived after his parents died. Pedersen's education is unknown, according to family records, but it is known he traveled extensively. On March 28, 1921 Pedersen married Reata Canady in Provo, Utah.
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He then drives to the Benedict house, covered in crude, to proclaim to the Benedicts that he will be richer than them. Jett makes a pass at Leslie, and this leads to a brief fistfight with Bick before he drives off. Jett's oil drilling company prospers over the years, and he tries to persuade Bick to let him drill for oil on Reata. Bick is determined to preserve his family legacy, however, and refuses.
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F. Stanley, Stanley F. L. Crocchiola, Jim Courtright (Denver: World, 1957). On March 28, 2000, at 6:15 pm, an F3 tornado struck downtown Fort Worth, severely damaging many buildings. One of the hardest-hit structures was the Bank One Tower, which was one of the dominant features of the Fort Worth skyline and which had Reata, a popular restaurant, on its top floor. It has since been converted to upscale condominiums and officially renamed "The Tower".
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Trailer for Giant Wealthy Texas rancher Jordan "Bick" Benedict Jr. travels to Maryland to buy a horse. There he meets and courts socialite Leslie Lynnton, who ends a budding relationship with British diplomat Sir David Karfrey and marries Bick after a whirlwind romance. They return to Texas to start their life together on the family ranch, Reata, where Bick's older sister Luz runs the household. Leslie meets Jett Rink, a local handyman, and he becomes infatuated with her.
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She leaves Jett a small piece of land on the Benedict ranch. Bick, who despises Jett, tries to buy back the land, but Jett refuses to sell. Jett makes the land his home and names it Little Reata. Over the next ten years, Leslie and Bick have twins, Jordan III ("Jordy") and Judy, and later have a daughter, Luz II. After discovering oil within a footprint left by Leslie, Jett begins drilling and strikes oil on his land.
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In 1879, Gerard began to write novels, with her first major work being a collaboration with her sister Dorothea under the joint pseudonym E. D. Gerard. Reata; or What's in a Name (1880) concerned a Mexican girl's attempts to adapt to European customs and was published in Blackwood’s Magazine. Subsequent novels published by the pair in the same magazine were Beggar My Neighbour (1882), The Waters of Hercules (1885), and A Sensitive Plant (1891). When Dorothea got married and moved, their collaboration ceased.
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Frequent headliners Acoustic Alchemy named a track on their fourth album, Reference Point, after the venue. Peter White's 1996 album and title track were named after the venue. The nightclub closed in 2001 (with Brave Combo as the closing night act), exactly eighteen years after Ornette Coleman Day, and was converted into a restaurant, Reata at Sundance Square. Four Day Weekend, a comedy troupe, began performing in the theater before the nightclub closed, and continued operating the space as Four Day Weekend Theater.
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In the early 1920s, when Eric was about 4 and Kristi-Ray was about 3, they moved to England for several years, while John Douglas did some work for the Vickers company. Prior to her retirement, Reata worked as a nurse at a Goodwill Industries facility in San Diego. At some unknown point, they were divorced. At the time of his death at age 70, Pedersen lived in Blandford, Massachusetts, a suburb of Springfield, home of the Springfield Armory and the Springfield rifle.
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A Phase 1 clinical trial, sponsored by Reata, was conducted to determine the safety profile of and appropriate dosing for subsequent phase II studies, as well as to evaluate antitumor activity in patients with advanced solid tumor or lymphoid malignancy. Grade 3 reversible liver transaminase elevations were reported. The maximum tolerated dose was 900 mg/day. NQO1 mRNA levels, indicative of Nrf2 pathway activation, were increased in peripheral blood mononuclear cells (PBMCs), and tumor biopsies showed decreased levels of NF-κB and cyclin D1.
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It is not known if his residence there had any connection to the armory. Typically, though, Pedersen was traveling when he died, of a coronary, while in Cottonwood, Yavapai County, Arizona, near Prescott, where the Pedersens had lived for a time earlier in their lives. Reata Pedersen died in 1969 in San Diego, age 85. In 1946 Pedersen married Christine J. Loomis Bond, a widow, who was superintendent of nursing at a hospital where Pedersen may have been a patient receiving treatment for tuberculosis.
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Baldwin locomotive of the railway. The Mexican International Railroad (Ferrocarril Internacional Mexicano) was one of the primary pre- nationalization railways of Mexico. Incorporated in Connecticut in 1882 in the interests of the Southern Pacific Railroad (SP), it opened a main line from Piedras Negras (across the Rio Grande from Eagle Pass, at the end of an SP branch line) to Torreón, on the Mexican Central Railway, in 1888, and to Durango in October 1892. Branches extended from Durango to Santa Catarina de Tepehuanes and Reata to Monterrey.
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Many of the cowboys were veterans of the Civil War; a diverse group, they included Blacks, Hispanics, Native Americans, and immigrants from many lands.Russell Freedman, Cowboys of the Wild West(1985) p. 103 The earliest cowboys in Texas learned their trade, adapted their clothing, and took their jargon from the Mexican vaqueros or "buckaroos", the heirs of Spanish cattlemen from the middle-south of Spain. Chaps, the heavy protective leather trousers worn by cowboys, got their name from the Spanish "chaparreras", and the lariat, or rope, was derived from "la reata".
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Many other instances of cowboy jargon were similarly borrowed from Mexican cowboys, including words such lariat, chaps, and "buckaroo", which are in turn corruptions of the Spanish "la reata", "chaparreras", and "vaquero". The exact term also refers to the bucking horses used in rodeo "roughstock" events, such as bareback bronc riding and saddle bronc riding. Some dictionaries define bronco as untrained range horses that roam freely in western North America, and may associate them with Mustangs; but they are not necessarily feral or wild horses. The only true wild horses are the Tarpan and Przewalski’s horse.
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The honda can be formed by a honda knot (or another loop knot), an eye splice, a seizing, rawhide, or a metal ring. The other end is sometimes tied simply in a small, tight, overhand knot to prevent fraying. Most modern lariats are made of stiff nylon or polyester rope, usually about 5/16 or 3/8 in (8 or 9.5 mm) diameter and in lengths of 28, 30, or 35 ft (8.5, 9 or 11 m) for arena-style roping and anywhere from for Californio-style roping. The reata is made of braided (or less commonly, twisted) rawhide and is made in lengths from to over .
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The town is well-known locally both for being the site of a 12,000-year-old woolly mammoth discovery during road construction in 1964 (the bones of which are now on display at the Royal Saskatchewan Museum in Regina), and being the nearest community to La Reata Ranch, a working cattle ranch that doubles as a resort and allows guests to experience a real cowboy lifestyle first-hand. Near the town of Kyle is the Clearwater Lake Regional Park. On the road to it stands one of the last few Drive-in theaters in Western Canada, which remains a very popular evening attraction for both young and old in the summer months.
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Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target. A series of synthetic oleane triterpenoid compounds, known as antioxidant inflammation modulators (AIMs), are being developed by Reata Pharmaceuticals, Inc. and are potent inducers of the Keap1-Nrf2 pathway, blocking Keap1-dependent Nrf2 ubiquitination and leading to the stabilization and nuclear translocation of Nrf2 and subsequent induction of Nrf2 target genes. The lead compound in this series, bardoxolone methyl (also known as CDDO-Me or RTA 402), was in late-stage clinical trials for the treatment of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus and showed an ability to improve markers of renal function in these patients.
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The National Railroad of Mexico gained control in 1901 after the death of Collis P. Huntington of the SP, and in June 1910 the government-owned Ferrocarriles Nacionales de México (National Railways of Mexico) took over the property. The line between Sauceda (west of Reata) and Matamoros (east of Torreón) was soon abandoned, as it was parallel to two ex-Mexican Central Railway and National Railroad of Mexico lines. On the other hand, construction of a branch from Allende north to the border at Ciudad Acuña, which had begun in 1911 and been suspended in 1913, was resumed in 1919, with the intent of connecting to a planned (and never-completed) branch of the Kansas City, Mexico and Orient Railway from San Angelo to Del Rio.Powell, p.
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Mexican Central Railway train, between 1884-1897 1903 map of the Mexican Central Railway and connections Written on this photo taken between 1911 and 1914 is "despedida de los constitucionalistas" (waving goodbye to the Constitutionalists) for soldiers standing on top of S.P. de M. railroad cars during the Mexican revolution The Mexican Central Railway (Ferrocarril Central Mexicano) was one of the primary pre-nationalization railways of Mexico. Incorporated in Massachusetts in 1880, it opened the main line in March 1884, linking Mexico City to Ciudad Juárez, across the Rio Grande from El Paso and connections to the Southern Pacific Railroad, Texas and Pacific Railway, and Atchison, Topeka and Santa Fe Railway. Other major branches included Irapuato to Guadalajara (completed in 1888), Chicalote to Tampico (completed in 1890), and Guadalajara to Manzanillo (completed in 1908). The Mexican Central acquired control in June 1901 of the Monterey and Mexican Gulf Railroad, which connected the Mexican International Railroad at Reata (near Monterrey) to Tampico, and connected its main line with this line at the Monterrey end through a branch from Gómez Palacio.
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