141 Sentences With "proof of principle" | Random Sentence Generator

This study provides a proof of principle that this is possible.

An anonymous source called it a "proof of principle" in the report.

"I would look at this study as a proof of principle," he said.

So far, these results aren't much more than a proof of principle, Nugent said.

Instead, it's proof of principle for a possible viable new strategy for combatting Ebola.

So it's solid proof-of-principle of sonification as an analytical tool for materials science.

Their latest research, published Tuesday in Nature Communications, is a "proof-of-principle" animal study.

That was a proof-of-principle, a "Can we do this?" sort of a thing.

That's why it makes sense and they've done it proof of principle in this clinical trial.

"We were looking for a treatment, not proof of principle," Raisman says, his voice rising defensively.

But the research so far provides the first proof of principle that VR can ease pain in chronic conditions.

Mr Castilla hopes for a proof-of-principle demonstration of his platform to be ready within a few months.

"Our initial experiments in this study provide proof of principle that we can do it in rats," Prausnitz said.

Medical experts like Dr. Lee agreed that the study is clever and innovative, and at least a proof of principle.

Ultimately, this is proof-of-principle research, and a human settlement on Mars remains an idea of the distant, speculative future.

"Certainly there are improvements to be made, but as far as a proof of principle experiment we were really excited," says Chen.

"It's exciting — an important proof of principle," said Jeffrey Gelfand, a neurologist specializing in MS at the University of California San Francisco.

Proof of principle, as scientists call it, has already been established for a sometimes devastating intestinal infection by the bacterium Clostridium difficile.

Experts said the new work represented a "proof of principle," a preview of what may be possible after further experimentation and refinement.

Kranzler said the study is an intriguiguing proof-of-principle that he suspects will spur subsequent studies needed to replicated these findings.

Image credit: CGS SpAIt's a hugely important proof of principle, demonstrating that it is possible to implement a gravitational wave observatory in space.

"I think with this work, we were able to give a proof of principle that grid cells are used for taking shortcuts," Banino said.

"Our experiment was a proof of principle and we understand this particular implementation is never going to be useful for long range communication," said Lum.

At the very least, this latest research provides an important proof-of-principle showing that dogs might be useful for sniffing out malaria in some settings.

At the moment, the SABRE detector is still in a proof of principle phase and is expected to begin observations in both hemispheres within the next few years.

"You do have to start with proof of principle," said Jennifer Barfield, an assistant professor in biomedical sciences at Colorado State University, about the low number of births.

Furthermore, the Army-IBM Stryker "proof of principle" exercise was able to wirelessly transmit sensor data, enabling AI to compare new information gathered against a historical database in seconds.

Freese and Drukier say a proof-of-principle paleo-detector would first have to demonstrate that it can find recoil tracks left by known particles such as solar neutrinos.

While people seldom end up thin, their permanent weight loss is a proof of principle, showing that treatments can lower the weight the brain forces a person to maintain.

The result provides proof of principle that Type 1 diabetes can be treated by growing a pancreas from an individual's cells in another animal, Dr. Nakauchi and colleagues conclude.

The other aspirant, Sewbo, which is based in Seattle, has made a T-shirt already, as a proof of principle, though it does not yet have a commercial production system.

When she first embarked on the dog research, to engage skeptics, she said it was purely proof-of-principle work, aimed at investigating whether human cancers really do have distinctive odors.

The Golden State Killer case is the tip of an iceberg: proof of principle that any crime leaving behind biological material from which genomic data can be extracted is likely solvable.

As a proof of principle, the researchers printed a single letter on individual sheets of paper and found that their technique could correctly identify the letters up to nine pages deep.

In this "proof of principle" experiment, a man whose spinal injury removed all sensation from his limbs was able to "feel" pressure on several robotic digits connected directly to his brain.

If successful, it will serve as a proof of principle for future space-based ultrahigh-energy cosmic-ray experiments, such as her proposed satellite detector, Poemma (Probe of Extreme Multi-Messenger Astrophysics).

" According to Dr. Trish Wong of Oregon Health and Science University, the new study "is truly amazing work -- proof of principle that a cure for this chronic, devastating disease is in sight.

This is an exhilarating proof of principle that with technology that is already within reach, we should be able to build a device that is clinically viable in patients with speech loss.

"This new paper really is an almost miraculous proof of principle," said Nicholas P. Money, a professor of botany at Miami University in Oxford, Ohio, who was not involved with the experiment.

In a proof of principle, researchers used neural progenitor cells to grow a kind of splice reconnecting severed nerve fibers coming from the rats' brains to the lower parts of the rodents' bodies.

In proof-of-principle studies over the last few years, Nathan Reid and his team at CSIRO, Australia's national science agency, have shown that biogeochemical prospecting closely tallies with the surface and groundwater analyses.

Helen Petousis-Harris, who co-led the study at the University of Auckland, said the findings "provide experimental evidence and a proof of principle" that meningitis vaccines might offer moderate cross-protection against gonorrhea.

His lab, serving as the first proof-of-principle cord blood bank for distant obstetric units, began studying the capacity of hematopoietic (blood) stem and progenitor cells to cure disease in the early '80s.

As proof of principle, the researchers showed that their analytical protocol had detected a second neural pathway in the brain for which scientists already had evidence — this one tuned to the sounds of human speech.

"It's the sort of proof-of-principle stuff you have to do if you're going to build up a real quantum network," said Graeme Smith, a physicist at JILA in Boulder, Colorado, who works on quantum technology.

Most of the groundbreaking technologies it will take to get to this point are either in human clinical trials, in animal trials where they have already provided proof of principle, or already exist and simply await commercialization.

These early CIMT studies on monkeys paved the way for a proof-of-principle case study, the first formalized study that attempted to apply the forced rewiring of a human brain in order to strengthen their weak extremity.

The small proof-of-principle study suggests a new way to inoculate babies, said Dr. Maria Gloria Dominguez-Bello, an associate professor of medicine at New York University and lead author of the report, published on Monday in Nature Medicine.

The study is also a "proof of principle paper" that shows that looking at the human microbiome can successfully lead to finding new antibiotics — and will hopefully inspire other researchers to look a little closer to home in the future.

Neural interfaces are not drugs but medical devices, which means that clinical trials can be completed with just a handful of patients for proof-of-principle trials, and just a couple of hundred for the trials that come after that.

Researchers wanted to test their device on a particularly tricky cut for proof of principle; they settled on the translabyrinthine opening, which traces a jigsaw-like path around the ear, where the bone is hard and the angles get strange.

The new system, described in the latest issue of Nature Nanotechnology, still requires considerable work before it's ready for prime time, but it's an important proof-of-principle that lays the groundwork for the development of useable atomic-scale data storage devices.

Now that the FreeSense proof-of-principle has been successfully demonstrated, the researchers hope to improve upon the design by testing it when multiple people are in the room at once and seeing how increasing the distance between the WiFi receiver and transmitter affects recognition accuracy.

"This is proof of principle that you can go out there and mitigate infections and that the method doesn't need to be that complex," said Trenton Garner, a biologist at the Zoological Society of London, who reported the findings with his co-authors in the journal Biology Letters.

"It's important to emphasize that this is a proof of principle, and it's not a clinical test yet," he said, adding that if it's made available in the future, "it's hard to tell right now" how much the blood test could cost, but it could be offered for around $100.

"This is an exhilarating proof of principle that with technology that is already within reach, we should be able to build a device that is clinically viable in patients with speech loss," says study author Edward Chang, professor of neurological surgery and member of the UCSF Weill Institute for Neuroscience.

Close-up of the drop tower capsulePhoto: ZARM Drop Tower Operation and Service CompanyA team of scientists announced they have harvested hydrogen from water in microgravity—a proof-of-principle test that may one day lead to a way to acquire fuel or other resources during a long-distance, crewed space mission.

Fed up with yet more inaction, a small group of developing countries might choose to engage in "minilateral" discussions over whether to "go it alone" with a sunshade scheme that would, if it worked, both cool the planet and provide a proof of principle that might persuade other countries to back the idea.

"As directed by the Chief of Staff of the Army, the Army is conducting a proof of principle to incorporate Man Portable Air Defense Systems back into the Armored Brigade Combat Teams by modifying two dozen Bradleys to carry Stinger Missiles in lieu of TOW Missiles," Ashley Givens, spokeswoman for Program Executive Officer, Ground Combat Systems, told Warrior Maven.

"This is a proof of principle that we can do this if the drugs are in the same class and tolerated when combined," said Dr. Toni Choueiri, director of the Lank Center for Genitourinary Oncology at Dana-Farber Cancer Institute/Brigham and Women's Hospital and a professor of medicine at Harvard Medical School in Boston, who was senior author of the avelumab study.

As proof-of-principle, experimental overexpression of these vsRNAs allows for increased viral accumulation in infected plants.

A proof of principle demonstrated the sensitivity of detecting tumor-derived circulating mitochondrial DNA in the plasma, CSF and urine of xenografted animals.

Hong demonstrated that high-dose retinoids can reverse oral carcinogenesis—a proof of principle that has led to additional ongoing studies in the area of cancer chemoprevention.

After the proof-of-principle phase (April to December 2007) the official start of the study was January 1, 2008. Sifap1 patients were recruited until June 30, 2009. Sifap2 runs simultaneously, and is scheduled to conclude on June 30, 2012.

From 1994 to 1998 he served as an Associate Member on the Australian Drug Evaluation Committee and was Principal Investigator in the proof-of-principle study that established the androgen-progestin combination as the most effective form of hormonal male contraception.

Commissioning of EMMA began in June 2010 when the beam was injected and sent around part of the ring. Full ring commissioning commenced in August 2010. As of March 31 2011, full ring circumnavigation was completed to establish proof of principle.

As the science of materials has advanced, photonic materials have been developed which use the photon of light as the fundamental carrier of information. This has led to photonic crystals, and at the beginning of the new millennium, the proof of principle for functioning metamaterials with a negative index of refraction in the microwave- (at 10.5 Gigahertz) and optical range. This was followed by the first proof of principle for metamaterial cloaking (shielding an object from view), also in the microwave range, about six years later. However, a cloak that can conceal objects across the entire electromagnetic spectrum is still decades away.

A Sandhoff disease study showing proof of principle for gene therapy in a human model system using CRISPR and virus gene correction gives the chance for clinical trials to cure the disease. The ultra-rare occurrence is a main hurdle to overcome for clinical trials.

Data from Jane's All the World's Aircraft 2011/12 ;M212-100:First prototype, proof-of-principle, one example only. ;M212-200: Production base level four-seater, flyaway or kit. Certification to JAR/FAR 23 planned. ;M212-300: Proposed two-seat aerobatic trainer, now abandoned.

The sensitivity of flow-cytometry, eliminates the need for PCR amplification of the target DNA (Rao et al. 2003). These high-throughput platforms have not progressed beyond the proof-of-principle stage and so far the Invader system has not been used in any large scale SNP genotyping projects.

Using computational subtraction to discover novel pathogens was first proposed in 2002 by Meyerson et al. using human expressed sequence tag (EST) datasets. In a proof of principle experiment, Meyerson et al. demonstrated that it was a feasible approach using Epstein-Barr virus-infected lymphocytes in post- transplant lymphoproliferative disorder (PTLD).

Other uses are less sinister; entertainment purposes and harmless pranks provide users with movie-quality artistic possibilities. The proof-of-principle software Face2Face was developed at the University of Erlangen-Nuremberg, the Max-Planck Institute for Informatics, and Stanford University. Such advanced video manipulation must be ranked alongside and beyond previous examples of deepfakes.

Hunt, p. 64 For the 1866 cable, it was planned to use the Magnetic's opposite polarity pulse method, but doubts were expressed over whether it would work over such a great distance. Magnetic connected together various of their British underground cables to provide a total line length of over for proof of principle testing.Bright, pp.

Upon the failure of a key component supplier (the pod) and while demand remained strong, the company ended operations on December 31, 2017, closing out the proof-of-principle R&D; phase of the project.Michael Zhang, "New55 is Dead Along With Its Dreams of Reviving 4×5 Peel-Apart Film". PetaPixel, 6 January 2018.

There are a large number of proof-of- principle experiments. Laser interferometers split a laser beam in two paths and overlap them again afterwards. If the relative optical path length changes, the interference changes, and the light power in the interferometer's output port as well. This light power is detected with a photo diode providing a continuous voltage signal.

Proof of concept (POC), also known as proof of principle, is a realization of a certain method or idea in order to demonstrate its feasibility, or a demonstration in principle with the aim of verifying that some concept or theory has practical potential. A proof of concept is usually small and may or may not be complete.

Pekola et al. demonstrated a proof-of-principle of an autonomous demon in coupled single-electron circuits, showing a way to cool critical elements in a circuit with information as a fuel. Pekola et al. have also proposed that a simple qubit circuit, e.g., made of a superconducting circuit, could provide a basis to study a quantum Szilard's engine.

Goliath laying the 1850 cable In 1847, the Bretts obtained a concession from the French government to lay and operate a submarine telegraph cable across the Channel. The concession lapsed without anything being achieved.Haigh, p. 192 A proof of principle was conducted in 1849 by Charles Vincent Walker of the South Eastern Railway Company using gutta-percha insulated cable.

Randomly partitioning a complete diploid fosmid library into various pools of equal size presents an alternative method for haplotype phasing. In the proof of principle description of this techniqueHaplotype- resolved genome sequencing of a Gujarati Indian individual. J.O. Kitzman et al. Nature Biotechnology vol 29 no 1 59-63 115 pools were created containing ~5000 unique clones from the original fosmid library.

Preliminary and proof-of-principle studies of Hof's method, as well as similar breathing practices, have shown that hyperventilating can temporarily suppress the innate immune response as well as temporarily increase heart rate and adrenaline levels. However, the broader medical claims made by Hof, such as the treatment of cancer and auto immune disease, have not been validated by any rigorous peer reviewed research.

COLD-PCR was originally described by Li et al. in a Nature Medicine paper published in 2008 from Dr. Mike Makrigiorgos's lab group at the Dana Farber Cancer Institute of Harvard Medical School. As summarized above, the technology has been used in a number of proof-of-principle experiments and medical research diagnostic experiments. Recently, the COLD-PCR technology has been licensed by Transgenomic, Inc.

LEAPT is a variant of DEPT in which the manipulation of carbohydrates on the surface of the enzyme is used to target the enzyme activity to the cell in question. This allows exploitation of the sometimes highly specific sugar-lectin interactions found in organisms, including humans. Proof-of-principle examples have shown delivery to target organs of enzymes that specifically release cytotoxics to treat tumours.

These small aberrations cannot be detected using cytogenetics or conventional CGH, but can be readily detected using array CGH. As a proof of principle Vissers et al. (2003) constructed a genome wide array with a 1 Mb resolution to screen three patients with known, FISH-confirmed microdeletion syndromes, including one with PWS. In all three cases, the abnormalities, ranging from 1.5 to 2.9Mb, were readily identified.

Phase I, from November 2004 to June 2007, involved USAREUR securing the necessary host nation agreements and constructing the facilities. Phase II would begin with the first “Proof of Principle” battalion-sized rotation in June 2007 and eventually followed by a full brigade combat team as the facilities, training areas and agreements were established and validated. The 2007 Phase I “Proof of Principle” and the 2008 Rotation were successful in validating the EETAF concept and provided key insights for further development. Key construction tasks identified for accomplishment in Phase I were not completed and insights were gained indicating significant improvement and expansion of facilities and training areas was required to meet the original brigade-sized concept; but, the plans had been developed, a timeline established, and funding allocated to complete construction of the identified Permanent Forward Operating Site (PFOS) in Romania and, later, one in Bulgaria.

A company called New55 Holdings, LLC, ("New55 FILM") based in Ashland, Massachusetts, brought to market a black and white 4x5 positive-negative material that is exposed and processed in a Polaroid 545 holder. New55 PN provided a positive print and a 4x5 negative that could be scanned, contact printed, or enlarged. Winding up their proof-of-principle R&D; phase, New55 Holdings, LLC, ceased operations in December 2017.

An extensive experimental investigation about the process of desorbing methane by adsorbing carbon dioxide in real coal samples was performed. The proof of principle and the technical feasibility of the method could be verified with these measurements. These research results indicate that CBM can become an alternative to conventional natural gas. ECBM provides additional to CBM the advantage of long-term CO2 storage in the underground coal seams.

This lattice or periodic, "magnetic" structure was constructed from non-magnetic components. Hence, in electromagnetic domain, a negative value for permittivity and permeability occurring simultaneously was a requirement to produce the first metamaterials. These were beginning steps for proof of principle regarding Veselago's original 1967 proposal. In 2000, a team of UCSD researchers produced and demonstrated metamaterials, which exhibited unusual physical properties that were never before produced in nature.

Web sites associated with home 3D printing tended to include backscratchers, coat hooks, door knobs, etc. The open source Fab@Home project has developed printers for general use. They have been used in research environments to produce chemical compounds with 3D printing technology, including new ones, initially without immediate application as proof of principle. The printer can print with anything that can be dispensed from a syringe as liquid or paste.

Shortly after the proof of principle paper MicroED was improved by applying continuous rotation during the data collection scheme. Here the crystal is slowly rotated in a single direction while diffraction is recorded on a fast camera as a movie. The methodology is like the rotation method in x-ray crystallography. This led to several improvements in data quality and allowed data processing using standard X-ray crystallographic software.

This information can then be used to infer protein structure. A proof of principle of this approach was shown by two groups using the protein GB1. Results from MPRA experiments have required machine learning approaches to interpret the data. A gapped k-mer SVM model has been used to infer the kmers that are enriched within cis-regulatory sequences with high activity compared to sequences with lower activity.

Truax had already experimented with this basic system in the Sea BeeAstronautix.com, Sea BeeSea Bee was a proof of principle program to validate the sea-launch concept. A surplus Aerobee rocket was modified so that it could be fired underwater. The rocket worked properly the first time in restrained mode. Later tests of repeat firings proved so simple that the cost of turn-around was about 7% that of a new unit.

Given that ABCC6 heterozygous mutations result in few symptoms of PXE, this disease is a candidate for gene therapy. Some initial proof-of-principle experiments have been done in mice that have relieved some of symptoms of PXE, but as with all gene therapy treatments, there are many hurdles that must be over come including insuring that the treatment will be long-lasting and reducing the risk of insertional mutagenesis and severe immune reactions.

The primary use of ionization cooling is envisaged to be for cooling of muon beams. This is because ionization cooling is the only technique that works on the timescale of the muon lifetime. Ionization cooling channels have been designed for use in a neutrino factory and a muon collider. Muon ionization cooling is expected to be demonstrated for the first time by the proof of principle International Muon Ionization Cooling Experiment (MICE).

Q-system appeared to be working successfully in a variety of organisms. It has been used to drive expression of luciferase, as a proof of principle, in cultured mammalian cells. In zebrafish the Q-system has been successfully used with several tissue-specific promoters, and was shown to work independently of the GAL4/UAS system when expressed in the same cell. In C. elegans the Q-system has been shown to work in muscles and in neuronal tissue.

Studies of correcting Wiskott–Aldrich syndrome with gene therapy using a lentivirus have begun. Proof-of-principle for successful hematopoietic stem cell gene therapy has been provided for patients with Wiskott–Aldrich syndrome. Currently, many investigators continue to develop optimized gene therapy vectors. In July 2013 the Italian San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET) reported that three children with Wiskott–Aldrich syndrome showed significant improvement 20–30 months after being treated with a genetically modified lentivirus.

The most prevalent model of quantum computing is the gate-based model where quantum computation is performed by sequential applications of unitary quantum gates on qubits of a quantum computer. A theory for the implementation of reservoir computing on a gate- based quantum computer with proof-of-principle demonstrations on a number of IBM superconducting noisy intermediate-scale quantum (NISQ) computersJohn Preskill. "Quantum Computing in the NISQ era and beyond." Quantum 2,79 (2018) has been reported in.

ASMs behave as unimolecular micelles, where four polymer particles are covalently bound. AScMs consist of part of the star like macromolecules, and must first aggregate to form micellar structures. Because AScMs are easier to synthesize and have similar properties, the polymers are undergoing further proof of principle research in gene delivery of siRNA and plasmid DNA with Professor Charlie Roth. Also, the anionic (negatively charged) scorpion-like molecules inhibit cellular uptake of oxidized LDL, the ‘bad’ cholesterol in the body.

J. Craig Venter Both Eigen and Sol Spiegelman demonstrated that evolution, including replication, variation, and natural selection, can occur in populations of molecules as well as in organisms. Following on from chemical evolution came the initiation of biological evolution, which led to the first cells. No one has yet synthesized a "protocell" using simple components with the necessary properties of life (the so-called "bottom-up-approach"). Without such a proof-of-principle, explanations have tended to focus on chemosynthesis.

J Assist Reprod Genet (2011) 28:77–83. This is an advantage because PGD methods such as FISH are able to reveal whether an embryo will express the phenotypic difference, but not whether an embryo may be a carrier.Altarescu G, Zeevi DA, Zeligson S, Perlberg S, Eldar-Geva T, Margalioth EJ, Levy-Lahad E, Renbaum P. Familial haplotyping and embryo analysis for Preimplantation Genetic Diagnosis (PGD) microarrays: a proof of principle study. J Assist Reprod Genet (2013) 30:1595–1603.

The first patient did remarkably well and survived for over 4 years after treatment, but the second died within a month of cardiac complications. Clearly, this is a very challenging approach for the treatment of hepatic metastases, and it is unlikely that it will ever be widely used. Nevertheless, the good clinical results in the first patient established proof of principle. Finally, Yanagie and his colleagues at Meiji Pharmaceutical University in Japan have treated several patients with recurrent rectal cancer using BNCT.

First plasma was obtained on NSTX on Friday, February 12, 1999 at 6:06 p.m. Magnetic fusion experiments use plasmas composed of one or more hydrogen isotopes. For example, in 1994, PPPL's Tokamak Fusion Test Reactor (TFTR) produced a world-record 10.7 megawatts of fusion power from a plasma composed of equal parts of deuterium and tritium, a fuel mix likely to be used in commercial fusion power reactors. NSTX was a "proof of principle" experiment and therefore employed deuterium plasmas only.

These studies were conducted using a scanning probe microscope as the sensing electrode, and have proved that bases can be identified by specific tunneling currents. After the proof of principle research, a functional system must be created to couple the solid state pore and sensing devices. Researchers at the Harvard Nanopore group have engineered solid state pores with single walled carbon nanotubes across the diameter of the pore. Arrays of pores are created and chemical vapor deposition is used to create nanotubes that grow across the array.

Cause of high variability in drug dissolution testing and its impact on setting tolerances. Euro J Pharm Sci. 12 (3),271–276.Mauger J., Ballard J., Brockson R., De S., Gray V., Robinson D., 2003. Intrinsic dissolution performance of the USP dissolution apparatus 2 (rotating paddle) using modified salicylic acid calibration tablets: Proof of principle. Dissol Technol 10(3), 6–15. The hydrodynamic studies of USP Dissolution Apparatus 2 mentioned above clearly showed that it does have intrinsic hydrodynamic issues which could result in problems.

COX-2 inhibitor may decrease the rate of polyp formation in people with familial adenomatous polyposis however are associated with the same adverse effects as NSAIDs. Daily use of tamoxifen or raloxifene has been demonstrated to reduce the risk of developing breast cancer in high- risk women. The benefit verses harm for 5-alpha-reductase inhibitor such as finasteride is not clear. A study showing a proof-of-principle has also been done with the human proteins IFNalpha2a and macrophage-CSF, produced by genetically modified hens.

3D printing can be particularly useful in research labs due to its ability to make specialized, bespoke geometries. In 2012 a proof of principle project at the University of Glasgow, UK, showed that it is possible to use 3D printing techniques to assist in the production of chemical compounds. They first printed chemical reaction vessels, then used the printer to deposit reactants into them. They have produced new compounds to verify the validity of the process, but have not pursued anything with a particular application.

Shockley later admitted that the workings of the team were "mixture of cooperation and competition". He also admitted that he kept some of his own work secret until his "hand was forced" by Shive's 1948 advance. Shockley worked out a rather complete description of what he called the "sandwich" transistor, and a first proof of principle was obtained on April 7, 1949. Meanwhile, Shockley worked on his magnum opus, Electrons and Holes in Semiconductors which was published as a 558-page treatise in 1950.

Zhang, et al., also report highly efficient reprogramming of mouse fibroblasts into induced neural stem cell-like cells (ciNSLCs) using a cocktail of nine components. Multiple methods of direct transformation of somatic cells into induced neural stem cells have been described. Proof of principle experiments demonstrate that it is possible to convert transplanted human fibroblasts and human astrocytes directly in the brain that are engineered to express inducible forms of neural reprogramming genes, into neurons, when reprogramming genes (Ascl1, Brn2a and Myt1l) are activated after transplantation using a drug.

Mullis also invented a UV-sensitive plastic that changes color in response to light. He founded Altermune LLC in 2011 to pursue new ideas on the immune system.Loxbridge and Dr Kary Mullis Announce the Formation of Altermune Technologies with $7m Seed Investment. Archived Mullis described the company's novel technology in a presentation: The first proof- of-principle of this technology, re-targeting pre-existing antibodies to the surface of a pathogenic strep bacteria using an alpha-gal modified aptamer ("alphamer"), was published in 2015 in collaboration with scientists at the University of California, San Diego.

So, a notable step occurred with the invention of a practical metamaterial at microwave frequencies,It was essentially a proof of principle demonstration, which was later commonly applied to the higher- frequency domain of terahertz and infrared. See negative index metamaterials. because the rudimentary elements of metamaterials have demonstrated a coupling and inductive response to the magnetic component commensurate with the electric coupling and response. This demonstrated the occurrence of an artificial magnetism,See main article: Paramagnetism and was later applied to terahertz and infrared electromagnetic wave (or light).

However, when analyzed together, the network of genes did significantly associate with the disorder. This finding represents an important proof-of-principle as the first demonstration of the power of a pathway approach to understanding human genomics. In 2009, the Center also published a genome-wide association study of inflammatory bowel diseases (Crohn's disease and ulcerative colitis) in 3,426 affected individuals and 11,963 genetically matched controls. Researchers identified five new regions associated with early-onset IBD, and detected associations at a number of loci previously implicated in adult-onset IBD.

In Sept. 2005, they reported observation of the quantum Hall effect in single graphene layers simultaneously with the group of Andre Geim, and in 2007, the two groups jointly published observations of the quantum Hall effect in graphene at room temperature. Kim's group authored an influential paper in 2007 describing a transport gap introduced by lithographic patterning of graphene to form nanoribbons. This was an important proof of principle in the development of graphene electronics as it allowed on-off switching of the graphene devices by a factor of 1000 at low temperature.

Gardner pioneered the transplantation of cells and tissues between blastocyst stage mouse embryos and their reconstruction from their component tissues. He was the first to apply clonal analysis to study cell fate and potency in mammals, and used this strategy to provide conclusive evidence against early segregation of the mammalian germline. Blastocyst injection was later adopted almost universally for assessing the developmental potential of embryonic stem (ES) cells and their competence to colonise the germline following genetic modification. With Robert Edwards, he also established proof of principle for preimplantation genetic diagnosis.

Georg Nagel, together with Peter Hegemann, is credited with the discovery of channelrhodopsins, which opened the new field of optogenetics. Early in 1995, Georg Nagel and Ernst Bamberg demonstrated that a microbial rhodopsin (Bacteriorhodopsin), when expressed in animal cells (Xenopus oocytes), is fully functional. In 2003, Nagel showed the functionality of Channelrhodopsin-2 (ChR2) in a mammalian cell line, where illumination with blue light caused a strong depolarization of the membrane potential. Following this proof-of-principle publication, ChR2 was expressed in hippocampal neurons in collaboration with Karl Deisseroth, where light pulses caused action potentials with high temporal precision.

In March 2005, President Traian Băsescu made his first official visit to Washington to meet with President Bush, Secretary of State Condoleezza Rice, Secretary of Defense Donald Rumsfeld, and other senior US officials. In December 2005, Secretary Rice visited Bucharest to meet with President Băsescu and to sign a bilateral defense cooperation agreement that would allow for the joint use of Romanian military facilities by US troops. The first proof of principle exercise took place at Mihail Kogălniceanu Air Base from August to October 2007. Romania formally terminated its mission in Iraq on June 4, 2009, and pulled out its troops.

PPRHs could be used as gene silencing tools acting by different mechanisms than triplex forming oligonucleotides (TFOs), antisense oligonucleotides or siRNAs. Upon binding to their targets, PPRHs can decrease the mRNA and protein levels of the selected genes. Their action has been demonstrated in vitro for a number of genes involved in metabolism (DHFR), proliferation (mTOR), DNA topology (TOP1), lifespan and senescence (telomerase), apoptosis (survivin, BCL2), transcription factors (MYC), proto-oncogenes (MDM2), replication stress (WEE1, CHK1) and Thymidilate synthase (TYMS) as part of a cancer gene therapy strategy. Their preclinical proof of principle has been proven in vivo using the antiapoptotic survivin gene.

The 60 mm ETC gun developed by the US Navy at FMC as an ETC CIWS proof of principle demonstrator. The XM291 is the best existing example of a working electrothermal-chemical gun. It was an alternative technology to the heavier caliber 140 mm gun by using the dual- caliber approach. It uses a breech that is large enough to accept 140 mm ammunition and be mounted with both a 120 mm barrel and a 135 mm or 140 mm barrel. The XM291 also mounts a larger gun tube and a larger ignition chamber than the existing M256 L/44 main gun.

Linear optics was not seen as a potential technology platform for quantum computation until the seminal work of Knill, Laflamme, and Milburn, which demonstrated the feasibility of linear optical quantum computers using detection and feed-forward to produce deterministic two-qubit gates. Following this there were several experimental proof-of-principle demonstrations of two-qubit gates performed in bulk optics. It soon became clear that integrated optics could provide a powerful enabling technology for this emerging field. Early experiments in integrated optics demonstrated the feasibility of the field via demonstrations of high- visibility non-classical and classical interference.

In 2003 APOPO was awarded a grant from the World Bank, which provided seed funding to research another application of the rats: tuberculosis (TB) detection at SUA. Bart Weetjens got a 3-year personal grant from Ashoka: Innovators for the Public in 2007. A TB detection program in Tanzania was launched in mid-2007 as a partnership with four government clinics. In 2008 proof of principle was provided in using trained rats to detect pulmonary tuberculosis in human sputum samples. In 2010 a research plan to evaluate the effectiveness and implementation of the rats in diagnosing tuberculosis was started.

Pin, J.M., Guigo, N., Mija, A., Vincent, L., Sbirrazzuoli, N., van der Waal, J.C., de Jong, E., ACS Sustain. Chem. Eng., 2014, 2, 2182-2190 Humins can also be subjected to thermal treatments in order to form interesting solid materials, such as lightweight and porous humin foams.Mija, A., van der Waal, J.C., van Klink, G., de Jong, E., Humins-containing foam, 2016, WO2017074183A8Tosi, P., van Klink, G.P., Celzard, A., Fierro V., Vincent, L., de Jong, E., Mija, A., ChemSusChem, 2018, 11, 2797-2809 Overall, humins appear to improve the final properties of the materials although research is mainly at the proof-of- principle stage (early).

Cultural, scientific, and educational exchanges were initiated, and in 1964 the legations of both nations were promoted to full embassies. In March 2005, President Traian Băsescu made his first official visit to Washington to meet with President Bush, Secretary of State Condoleezza Rice, Secretary of Defense Donald Rumsfeld, and other senior U.S. officials. In December 2005, Secretary Rice visited Bucharest to meet with President Băsescu and to sign a bilateral defense cooperation agreement that would allow for the joint use of Romanian military facilities by U.S. troops. The first proof of principle exercise took place at Mihail Kogălniceanu Air Base from August to October 2007.

In the treatment of epilepsy, drugs such as vigabatrin that target both GABA transporters and the GABA metabolizing enzyme GABA-transaminase have been marketed, providing proof of principle for the neurotransmitter cycling systems as pharmacological targets. However, with regard to glutamate transport and metabolism, no such drugs have been developed, because glutamatergic synapses are abundant, and the neurotransmitter glutamate is an important metabolite in metabolism, making interference capable of adverse effects. So far, most of the drug development directed at the glutamatergic system seems to have been focused on ionotropic glutamate receptors as pharmacological targets, although G-protein coupled receptors have been attracting increased attention over the years.

Styblo's life's work was to develop, pioneer, and demonstrate the "proof of principle" for the strategy used to control TB by the World Bank and promulgated by the World Health Organization (WHO). Called Directly Observed Therapy – Short Course (DOTS), the TB therapy revolutionized the fight to control TB throughout the world. DOTS has been employed by 187 of the 193 members of WHO as of 2008. Styblo applied this methodology to the national TB control programs of Tanzania, Benin, Malawi, Mozambique, Nicaragua, and China; DOTS has been described as the "most effective means of controlling the current tuberculosis epidemic" and had been applied in over 90 countries as of 2001.

In 1974, Paoletti joined the Wadsworth Center for Laboratories and Research at the New York State Department of Health in Albany as a Senior Research Scientist. Four seminal papers, all published in the Proceedings of the National Academy of Sciences with Dennis Panicali and others provided the technology and proof of principle to construct live vaccines using genetically engineered poxviruses. In 1990 Paoletti's laboratory was the first to sequence the genome of vaccinia virus, an achievement gained without the use of high-throughput DNA sequencers. In 1981, Paoletti founded and was the Founding Scientist of Virogenetics Corporation, a private, for-profit company based in Troy, New York to commercialize vectored vaccines.

These are short genomic regions with a high density of CpG dinucleotides, and are commonly found in an unmethylated state within or nearby to an active gene's promoter. Bird's group discovered that the MeCP2 protein binds specifically to methylated CpG sites, and further that disruption of this interaction causes the autism spectrum disorder Rett syndrome. The Bird lab also implicated nuclear receptor co-repressor 1 as an important binding partner in the MeCP2/methyl-CpG interaction. In 2007 the Bird laboratory published a paper in the journal Science describing a proof- of-principle that the murine equivalent of Rett syndrome could be successfully reversed in laboratory mice.

Specifically, suppose the probability of generating a single photon by means of a PDC crystal is ε. Then, the probability of generating simultaneously M single photons is εM, which decreases exponentially with M. In other words, in order to generate the input state for the boson sampling machine, one would have to wait for exponentially long time, which would kill the advantage of the quantum setup over a classical machine. Subsequently, this characteristic restricted the use of PDC sources to proof-of-principle demonstrations of a boson sampling device. Recently, however, a new scheme has been proposed to make the best use of PDC sources for the needs of boson sampling, greatly enhancing the rate of M-photon events.

In addition to his interest in the mechanisms of stroke and best practices for treatment, Hachinski also has a keen research interest in stroke prevention. He acted as the principal neurological investigator on several seminal, multicentre studies, beginning with the Canadian-American Ticlopidine study (1983–88) and the Extracranial/Intracranial Arterial Bypass Surgery trial (1983–87). The former showed a preventative advantage to the drug Ticlopidine over commonly-prescribed Aspirin, while the latter showed that the increasingly popular and very expensive EC/IC arterial bypass procedure did not significantly reduce the risk of ischemic stroke. In 2003, alongside several other researchers, Hachinski began a proof of principle study through the Canadian Stroke Network on secondary stroke prevention.

In 2011, researchers at MIT used time-dependent density functional theory, which models systems at an atomic level, to design a system composed of azobenzene molecules bonded to carbon nanotube (CNT) templates. The CNT substrates will allow customizable interactions between neighboring molecules which greatly helps in fine tuning the properties of the fuel, for example an increase in the amount of energy stored. Through experimental procedures, researchers were able to get the first proof of principle that the hybrid nanostructure works as a functional thermal fuel. Azobenzenes have the advantage of absorbing wavelengths that are very abundant in sunlight, when this happens the molecule transforms from a trans-isomer to a cis-isomer which has a higher energy state of about 0.6 eV.

EMMA is a proof-of-principle machine; the experience gained in building this machine will be useful for future muon accelerators (which could be used in neutrino factories), and also for proton and carbon ion particle accelerators, which have applications for cancer therapy. Non-scaling FFAGs are a good candidate for use in an accelerator-driven subcritical reactor system in which a non- critical fission core is driven to criticality by a small accelerator. Future electrical power generation could be influenced heavily by the use power stations consisting of a sub-critical core containing a material such as thorium, and a small accelerator capable of providing extra neutrons via a spallation target. EMMA was funded by the BASROC consortium, under the CONFORM umbrella.

His certificate of election reads: In 2015 he received the Heinrich Wieland Prize "for his breakthrough concept of optogenetics and its proof of principle" and in 2016 the Wilhelm Exner Medal Miesenböck was elected a member of the European Molecular Biology Organization (EMBO) in 2008, and a member of the Academy of Medical Sciences, United Kingdom in 2012, the Austrian Academy of Sciences in 2014, and the German Academy of Sciences Leopoldina in 2016. In 2017, Trinity College Dublin awarded him with an honorary doctorate. In 2019, Miesenböck received the Rumford Prize for "extraordinary contributions related to the invention and refinement of optogenetics," with Ernst Bamberg, Ed Boyden, Karl Deisseroth, Peter Hegemann, and Georg Nagel. In the same year, he, Boyden, Deisseroth, and Hegemann won the Warren Alpert Foundation Prize.

The molecule works as a photodynamic agent upon irradiation at 660 nm under conditions of relatively high sodium and proton ion concentrations by converting triplet oxygen to cytotoxic singlet oxygen. This prototypical example would take advantage of the higher sodium levels and lower pH in tumor tissue compared to the levels in normal cells. When these two cancer-related cellular parameters are satisfied, a change is observed in the absorbance spectrum. This technique could be useful for the treatment of malignant tumors as it is non-invasive and specific. Two-input AND logic gate by Ozlem and Akkaya with photodynamic therapeutic applications A molecular logic gate can processes modulators much like the set up seen in de Silva’s ‘Proof-of- principle’ but incorporating different logic gates on the same molecule.

Thus, much effort has been paid so far to reducing the negative effects of ion trapping which has an adverse effect on the performance of electron storage rings. The novel idea to be employed at SCRIT is to use the ion trapping to allow short-lived RI's to be made a target, as trapped ions on the electron beam, for the scattering experiments. This idea was first given a proof-of-principle study using the electron storage ring of Kyoto University, KSR; this was done using a stable nucleus of 133Cs as a target in an experiment of 120MeV electron beam energy, 75mA typical stored beam current and a 100 seconds beam lifetime. The results of this study were favorable with elastically scattered electrons from the trapped Cs being clearly visible.

Based on the Beckley/Imperial Research Programme's psilocybin study brain imaging results, in 2012, the Medical Research Council awarded funding to the programme for a clinical study investigating psilocybin in the treatment of depression. Results from the study, published in the Lancet Psychiatry Journal, showed that two doses of psilocybin lifted depression in all 12 volunteers for three weeks, and kept five of them depression free for three months. The size of the study and the absence of a placebo make the research proof of principle only, but the remarkably positive results highlight the need for continued research in this promising area of psychiatry – psychedelic-assisted therapy. Amanda Feilding and the Beckley Foundation are currently trying to secure funding to expand this research and further evaluate the potential of psilocybin as a treatment for depression.

An earlier tool for photostimulation, cHARGe, demonstrated proof of principle in cultured neurons but was never used by other groups since it operated with a precision on the order of seconds, was highly variable, and did not allow control of individual action potentials. A second study was published later by Peter Hegemann's and Stefan Herlitze's groups confirming the ability of ChR2 to control the activity of vertebrate neurons, at this time in the chick spinal cord. This study was the first wherein ChR2 was expressed alongside an optical silencer, vertebrate rhodopsin-4 in this case, demonstrating for the first time that excitable cells could be activated and silenced using these two tools simultaneously, illuminating the tissue at different wavelengths. The groups of Alexander Gottschalk and Ernst Bamberg (with Georg Nagel taking the experimental lead) demonstrated that ChR2, if expressed in specific neurons or muscle cells, can evoke predictable behaviors, i.e.

The Michael J. Fox Foundation subsequently announced that it was supporting proof-of-principle studies on befiradol (also known as NLX-112) in models of Parkinson's disease and showcased Neurolixis in its Partnering Program. In January 2018, the British charity Parkinson's UK announced that it had awarded Neurolixis a grant to advance development of befiradol up to clinical phase in Parkinson's disease patients. In March 2019, Neurolixis announced that the US Food and Drug Administration (FDA) gave a positive response to Neurolixis' Investigational New Drug (IND) application for befiradol to be tested in a Phase 2 clinical study in Parkinson's disease patients with troublesome Levodopa-induced dyskinesia. F-15599 (also known as NLX-101) was awarded Orphan Drug Status by the United States Food and Drug Administration (FDA) in October 2013 and Orphan Medicinal Product designation by the European Medicines Agency in March 2014.

Von Neumann addressed the evolutionary growth of complexity amongst his self-replicating machines. His "proof-of-principle" designs showed how it is logically possible, by using a general purpose programmable ("universal") constructor, to exhibit an indefinitely large class of self-replicators, spanning a wide range of complexity, interconnected by a network of potential mutational pathways, including pathways from the most simple to the most complex. This is an important result, as prior to that it might have been conjectured that there is a fundamental logical barrier to the existence of such pathways; in which case, biological organisms, which do support such pathways, could not be "machines", as conventionally understood. Von Neumann considers the potential for conflict between his self-reproducing machines, stating that "our models lead to such conflict situations",Toward a Practice of Autonomous Systems: Proceedings of the First European Conference on Artificial Life, Francisco J. Varela, Paul Bourgine, (MIT Press 1992), page 236 indicating it as a field of further study.

Mark Humayun, who joined the faculty of the Keck School of Medicine of USC Department of Ophthalmology in 2001; Eugene Dejuan, now at the University of California San Francisco; engineer Howard D. Phillips; bio-electronics engineer Wentai Liu, now at University of California Los Angeles; and Robert Greenberg, now of Second Sight, were the original inventors of the active epi- retinal prosthesis and demonstrated proof of principle in acute patient investigations at Johns Hopkins University in the early 1990s. In the late 1990s the company Second Sight was formed by Greenberg along with medical device entrepreneur, Alfred E. Mann,Second Sight. 14 November 2014 Second Sight Amendment No. 3 to Form S-1: Registration Statement Their first- generation implant had 16 electrodes and was implanted in six subjects by Humayun at University of Southern California between 2002 and 2004. In 2007, the company began a trial of its second-generation, 60-electrode implant, dubbed the Argus II, in the US and in Europe.

Von Neumann's goal, as specified in his lectures at the University of Illinois in 1949, was to design a machine whose complexity could grow automatically akin to biological organisms under natural selection. He asked what is the threshold of complexity that must be crossed for machines to be able to evolve and grow in complexity. His “proof-of-principle” designs showed how it is logically possible. By using an architecture that separates a general purpose programmable (“universal”) constructor from a general purpose copier, he showed how the descriptions (tapes) of machines could accumulate mutations in self-replication and thus evolve more complex machines (the image below illustrates this possibility.). This is a very important result, as prior to that, it might have been conjectured that there is a fundamental logical barrier to the existence of such machines; in which case, biological organisms, which do evolve and grow in complexity, could not be “machines”, as conventionally understood.

In 1991, George Kollias' group was first to provide in vivo, proof of principle studies, on deregulated TNF production being causal to the development of chronic polyarthritis in a transgenic animal model, and for showing originally that anti-huTNF antibody treatment was efficacious in treating the modeled disease (pg. 370). These studies were instrumental in mobilizing the interest of anti- TNF industry and foreshadowed the success of the first clinical trials performed in RA in 1994. Further work in his lab provided insights into the function of TNF in host defense and the structure and function of secondary lymphoid organs, a work that more recently evolved into the establishment of TNFRI and NFkB signals specifically in follicular dendritic cells (FDCs) being of pivotal significance in the regulation of humoral B cell responses and autoimmunity. Moreover, George Kollias' group demonstrated TNF’s causal effect in the development of combined Crohn's disease and polyarthritis, and the contribution of transmembrane versus soluble TNF in the pathogenic processes.

However, the process, as described, was only a proof of principle, suitable only for the fabrication of discrete transistors and not for integrated circuits; and was not pursued any further by its investigators. In 1968, the MOS industry was prevalently using aluminum gate transistors with high threshold voltage (HVT) and desired to have a low threshold voltage (LVT) MOS process in order to increase the speed and reduce the power dissipation of MOS integrated circuits. Low threshold voltage transistors with aluminum gate demanded the use of [100] silicon orientation, which however produced too low a threshold voltage for the parasitic MOS transistors (the MOS transistors created when aluminum over the field oxide would bridge two junctions). To increase the parasitic threshold voltage beyond the supply voltage, it was necessary to increase the N-type doping level in selected regions under the field oxide, and this was initially accomplished with the use of a so-called channel-stopper mask, and later with ion implantation.

In 2000, Gregory Verdine and colleagues reported the first synthesis of an all-hydrocarbon cross-link for peptide α-helix stabilization, combining the principles of RCM with α,α-disubstitution of the amino acid chiral carbon and on-resin peptide synthesis. In collaboration with Edward Taylor of Princeton University, Loren Walensky, who was then a post-doc in Verdine's lab, subsequently demonstrated that stapling BH3 peptides enabled the synthetic peptides to retain their α-helical conformation, further demonstrating that these peptides were taken up by cancer cells and bound their physiologic BCL-2 family targets, which correlated with the induction of cell death. Walensky discovered that the peptides side-stepped the membrane diffusion issue by crossing the membrane through active endosomal uptake, which deposited the peptides inside of the cell. Since this first proof of principle, peptide stapling technology has been applied to numerous peptide templates, allowing the study of many other PPIs using stapled peptides including cancer targets such as p53, MCL-1 BH3, and PUMA BH3, as well as other therapeutic targets ranging from infectious diseases to metabolism.

The impact was a considerable reduction in the switching speed of transistors. In 1966, Robert W. Bower realized that if the gate electrode was defined first, it would be possible not only to minimize the parasitic capacitances between gate and source and drain, but it would also make them insensitive to misalignment. He proposed a method in which the aluminum gate electrode itself was used as a mask to define the source and drain regions of the transistor. However, since aluminum could not withstand the high temperature required for the conventional doping of the source and drain junctions, Bower proposed to use ion implantation, a new doping technique still in development at Hughes Aircraft, his employer, and not yet available at other labs. While Bower’s idea was conceptually sound, in practice it did not work, because it was impossible to adequately passivate the transistors, and repair the radiation damage done to the silicon crystal structure by the ion implantation, since these two operations would have required temperatures in excess of the ones survivable by the aluminum gate. Thus his invention provided a proof of principle, but no commercial integrated circuit was ever produced with Bower’s method.