Compared to major cities like London and Paris, which have, respectively, blue plaques and extensive markers, New York features very few plaques for its cultural history.
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Budd Haeberlein believes that targeting plaques is key to getting the first therapies going, as the plaques appear in the brain up to 20 years before symptoms begin.
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But it's a different question: if you block the development of the plaques can you impact the disease, (versus) if I remove the plaques can I impact the disease?
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In people who have fatty deposits in their arteries, known as artherosclerotic plaques, the plaques can break off and trigger clotting, obstructing blood flow to the heart or brain.
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The site includes an oval outer wall of stone with plaques featuring quotes from officials and Columbine students and teachers, and an inner ring with plaques for each person killed.
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" Monuments removed: Three plaques commemorating Confederate soldiers The plaques were removed from the city's Riverfront Park a day after after Daytona Beach Mayor Derrick Henry told a News-Journal reporter that he didn't think the plaques "need to have a prominent place in public life if it is in homage to the Confederacy.
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As noted in the new study, this analysis revealed traces of amyloid beta plaques in all 20 chimpanzee brains, and as with humans, the volumes of these plaques increased with age.
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They also cannot explain why exercise might contribute to plaques, or whether, over time, the athletes with plaques are at any greater risk than other people of experiencing a heart attack.
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The authors of that study question the significance of this observation because plaques with calcium are more stable than non-calcified plaques and therefore less likely to cause a heart attack.
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But such commemorations — plaques, portraits, statues — are always complicated.
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Results of early human and animal Alzheimer's trials show that verubecestat significantly reduces the levels of amyloid beta plaques that cause damage by inhibiting a protein necessary for the plaques to form.
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Inconspicuous plaques mentioning "Soviet victims of Nazi aggression" were placed at a handful of the larger sites, where they joined the thousands of plaques and memorials on every corner of the Soviet Union.
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At Duesseldorf and Barcelona airports, memorial plaques were also unveiled.
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"One Train Can Hide Another" their neat enamel plaques declare.
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Hypertension has also been tied to such plaques, she added.
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They allow plaques and tangles to accrete in the brain.
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But for me, the bars (or plaques) remain the draw.
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But privately her heroism endured without medals, plaques or flags.
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Attacking amyloid plaques Like other anti-amyloid drugs, solanezumab was designed to reduce the build up of amyloid plaques on the brain, which are thought to contribute to the memory loss associated with Alzheimer's disease.
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Now many of Dongshan's buildings have plaques showing they are protected.
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And now, he can check "delivering platinum plaques" off his list.
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Something like 840 of the plaques have "memory" in their wording.
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Core values are not fluffy plaques to hang on the wall.
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A number of his public sculptures and plaques have been restored.
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Judges hold court from booths bearing plaques etched with their names.
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Plaques for some of these businesses adorn the neighborhood's sidewalks today.
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The dermatologist took biopsies of the red plaques on her hands.
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The flags are gone, but the plaques that described them remain.
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The tissue was pocked with amyloid plaques that resembled black clouds.
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It's unclear whether the parks department will replace the memorial plaques.
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This was odd because the individuals, age 28 to 63, were too young to have developed the amayoid plaques indicative of the neurological disorder (amyloid plaques are a misfolded protein that fuels the spread of Alzheimer's).
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But the studies also find that these plaques seem to differ somewhat in their makeup from the kinds of plaques found in less active people's hearts and so may not be a cause for much concern.
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Solanezumab is a monoclonal antibody that removes amyloid by attaching itself to free-floating amyloid protein before the protein forms into plaques, while several other antibody drugs also attack amyloid fibrils that are part of the plaques.
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Both Abels and Egan are commemorated with plaques in the temple itself.
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He signed ten dash plaques for the cars, as did Carroll Shelby.
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However, he isn't calling for the statues or plaques to be removed.
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Researchers will also look for microbes in plaques found in human brains.
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Plaques for albums by Missy Elliott and OutKast hung on the walls.
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Mute plaques suggest an equality, entirely absent, among the players they honor.
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As measured by PET brain scans, treatment with aducanumab reduced brain plaques based on both duration and dose; all groups showed more reduction in plaques over time, and the highest-dose group showed the greatest reduction of all.
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In someone with full-blown Alzheimer's, abnormal clumps of both proteins, called plaques and tangles, respectively, form and litter the brain (plaques are mostly found in the space between nerve cells, while tangles mostly form inside nerve cells).
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Lining the wall of the hallway were about a dozen large memorial plaques.
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Crenezumab works by targeting protein plaques found in brains of patients with Alzheimer's.
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Outside was Sam Shephard reading all the famous artist plaques on the wall.
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Show your coworkers who's boss with these desk plaques for $28 each here.
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These ornate glass pieces included vases, large wall plaques, and small jewelry items.
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By the next afternoon, the plaques, signs, and flaming skulls were gone. ♦
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On its facade are stunning sculptured plaques of sea horses, conchs and starfish.
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A spokesperson for the organization told ABC News that the plaques were temporary.
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Accompanying plaques explain how Flint was aided in his efforts by Theodore Roosevelt.
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The women were treated to massages and given plaques to acknowledge their activism.
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More plaques usually meant more severe dementia, in both older and younger patients.
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Past and Present There are important monuments, plaques and sites on the island.
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This allowed us to measure neural activity and the presence of Alzheimer's plaques.
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At the lowest LDL levels — around 24 — 81 percent of patients' plaques shrank.
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With Alzheimer's, abnormal proteins accumulate into plaques and tangle between the brain's nerve cells.
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But the sacred ground area bears no signs or plaques commemorating the shooting victims.
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By the time the brain is loaded with plaques, the damage is already done.
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Aducanumab works by removing brain plaques largely made from a protein called beta amyloid.
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You can even read the commemorative plaques placed in front of famous old buildings.
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More than 60,000 of the brass plaques have been set into pavements across Europe.
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I've probably walked over these plaques a thousand times and haven't ever noticed them.
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The lime-wood plaques on which the portraits are painted are from central Europe.
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The hallway is lined with plaques honoring horses killed in the line of duty.
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Both envoys carried photos of plaques at their respective embassies commemorating November 17 victims.
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Amyloid forms plaques outside of brain cells, while tau forms tangles within the cells.
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Brass plaques packed with names of fallen Kenyan Wildlife Service officers cover three sides.
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After breaking the record, Newton and Hallow were awarded plaques to signify their victory.
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The decline was three times as fast for those with existing beta-amyloid plaques.
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And some unlucky people will have to come up with wording for their plaques.
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Civil War statues and plaques have resulted in midnight removals in Baltimore and Annapolis.
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"Tourists ride scooters over plaques commemorating businesses burned down and never rebuilt," he said.
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Various bronze plaques bearing inspirational inscriptions are set into the concrete around the statue.
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In 1922, couples would have plaques made of themselves to hang as a decoration.
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Research has shown that the smaller the plaques, the lower the heart attack risk.
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You write it for the platinum plaques, but you take whatever badge it gets.
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There are generally small plaques at such shows that warn of the strobe lights.
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Psoriasis is an autoimmune disease that appears on the skin as plaques (red, dry skin).
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An illustration of plaques, seen in brown, and tangles, seen in blue, in the brain.
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Dobney began looking at calcified plaques in the 1980s, when he was in his 20s.
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I think we've demonstrated in the earlier study that our antibody does remove those plaques.
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" She added, "I had seriously started to believe all those dicks with plaques were right.
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The woman's brain was laden with the foremost hallmark of Alzheimer's: plaques of amyloid protein.
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But plaques and trophies and show posters are, by design, not part of the décor.
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MOTHA masks itself in the makeup of the museum—storied artifacts, informative plaques, intelligent lighting.
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The trails were lined with informational plaques featuring historic photos of the now-abandoned mine.
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Before street art, Kaltenbach placed single message bronze plaques and stencil graffiti around the city.
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You can't get too close and you read some plaques and it's freezing out there.
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And amyloid doesn't explain everything about Alzheimer's — not everyone with amyloid plaques has the disease.
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Patients with the mutation appeared to develop only plaques and tangles, and no other pathologies.
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Now, I do have some military memorabilia in my office: swords, plaques, prints of soldiers.
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They also serve as a necessary and needed counterbalance to the seriousness of most plaques.
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In the United States, we often honor similar achievements with bronze cleats mounted to plaques.
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The capital boasts over 900 official plaques, nodding to notable figures and important historical sites.
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In both studies, a long history of heavy exercise was linked to having arterial plaques.
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Now some scientists believe that the focus on amyloid plaques might have been a mistake.
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Some plaques bear the names of illustrious figures in music, including Chopin, Mozart and Bartok.
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Vendors on the platform offered crystal ornaments, tea services and plaques mounted with taxidermied squirrels.
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From 2011 to 2013, they used PET scans to measure their level of amyloid plaques.
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The plaques were wedged into boulders that mark the pathway toward the park's scenic overlook.
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These plaques subsequently set another process in motion, whereby tau forms tangles that destabilize brain cells.
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Together, the neuronal disruptions caused by these plaques and tangles result in the onset of dementia.
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Alongside the plaques, however, there is a push to rediscover the wine-making region's Jewish roots.
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The plaques marked the first time that any Jewish family was given public recognition in Tokaj.
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In Alzheimer's disease, this process goes off the rails, leading to the uncontrolled buildup of plaques.
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The Zimmermanns contacted the company last year and after lengthy negotiations, the plaques were put up.
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A total of 3,000 were selected and will be shrunk and engraved on two metal plaques.
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Before they form into plaques, misfolded amyloid beta molecules bunch into smaller clumps known as oligomers.
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At several strategic street corners, psalms and other Bible verses can be seen on metal plaques.
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In Alzheimer's, a type of dementia, the brain physically becomes degraded by malicious plaques and proteins.
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Slow down: It still isn't clear if tau tangles, amyloid plaques or something else cause Alzheimer's.
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Orly Fernandez is awake and handling the fill-in-the-blank plaques that accompany every casket.
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But the golden type on the plaques lists all of an inductee's teams in equal size.
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After putting the plaques down, Mr. Dean walked into the next room, a small recording space.
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Just before Christmas, the daughter went through Lord & Taylor for a last look at the plaques.
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Over by the darts hang "Hall of Fame" plaques bearing the engraved names of all-timers.
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Various plaques and signs around England contend otherwise, claiming to be the birthplace of lawn tennis.
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Dorm rooms are tiny, and my flower decorations, picture frames and inspirational quote plaques couldn't fit.
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But in the meantime, his friend found the screws the Parks Department uses for the plaques.
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Men and women who reported feeling sleepy during the day had higher levels of brain plaques.
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One is constantly reminded by such plaques and posts that the people here have known worse.
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The same day, a Brooklyn church removed two plaques that honored Lee from a churchyard tree.
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Cafes there engraved his name on plaques on his favorite seats, permanently reserving them for him.
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It is covered with plaques bearing the names of some of those who have been killed.
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For reprints, e-prints, logo and accolade licensing, permissions, plaques and other products, please click bit.
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Cerebrospinal fluid analysis revealed tell-tale amyloid plaques and neurofibrillary tangles, the fingerprints of Alzheimer's disease.
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There's brass plaques that you'll see on a building that's like The Women's Club of Indianapolis.
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The classic "On Social Grease" (1975) consists of six magnesium plaques suitable for a corporate lobby.
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Even when drugs can clear the plaques in patients' brains, the disease continues to wreak damage.
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These decorative plaques and handles have helped to date many burials to the 1720s to 1790s.
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Monuments removed: Two plaques honoring Robert E. Lee The Lee plaques were affixed to a tree on the grounds of St. John's Episcopal Church in Brooklyn, marking a spot where the Confederate general reportedly planted a tree while serving in the US Army during the 1840s.
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The formation of plaques is believed to occur much earlier than the formation of tangles, so many scientists have been trying to develop drugs to clear the brain of plaques, explained Dr. Ganesh Babulal, a researcher in the department of neurology at Washington University in St. Louis.
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But these are formed much later in the disease than the plaques, resulting in faster cognitive decline.
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With high hopes, drugs to fight brain plaques were tested in people genetically destined to develop dementia.
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Although most aging brains contain some plaques, the brains of Alzheimer's patients tend to have much more.
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The plaques are super playful and are sure to add comic relief to an otherwise stressful day.
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The plaques, with Griffey's and Piazza's the first to be sculpted by Tom Tsuchiya, are popular objects.
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Dennis Eckersley and Hoyt Wilhelm pitched for both but wear other teams' caps on their Cooperstown plaques.
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"No plaques had ever been displayed, no list of names read, no memorial services held," she wrote.
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Buddhist pilgrims traversing India in the first millennium A.D. carried small clay plaques stamped with religious symbols.
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On autopsy, he found peculiar plaques and twisted, spaghetti-like proteins known as tangles in her brain.
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It was difficult to identify what some of the Emmys were for; the plaques were too faded.
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Dr. Moir's theory involved the protein beta amyloid, which forms plaques in the brains of Alzheimer's patients.
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The microglia became more efficient at chewing up the amyloid protein that forms toxic plaques in Alzheimer's.
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The plaques I created for Greensboro will be viewed in a public context on South Elm Street.
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I would caution against any universal approach to all markers and monuments and plaques and street names.
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He said the monuments appear to be large rectangular stones with plaques that carry some sort of inscription.
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And it's these oligomers, not the plaques, that seem to be the most toxic to surrounding brain cells.
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Reflective brass plaques inscribed with the work's title denote victims whose photos Malallah couldn't locate in her research.
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At Ultra's office, the plaques on the wall commemorate not just sales figures but also YouTube subscriber milestones.
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Another is the beta-amyloid protein fragments that accumulate and form plaques between nerve cells in the brain.
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Also dotting his workspace are plaques made by Zillow Group's legal team to celebrate acquisitions, divestitures, and investments.
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Amyloid drugs may work best in patients who have yet to develop plaques readable on scans, Gandy added.
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Plaques and tangles, in this theory, are essentially just the "dead," inactive remains of amyloid and tau prions.
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They have one or two rooms, large windows and ornate plaques - some inside, some outside - memorializing the deceased.
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Lawmakers in a number of states have pushed to remove monuments, plaques and other homages to the Confederacy.
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Matloff and his partner, artist C Bangs, have been ruminating on holographic message plaques for nearly two decades.
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The plaques feature a photo of the actor's character engraved into the wood along with a notable quote.
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The report also recommended erecting sculptures or plaques to provide context about the massacre and Jim Crow era.
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Once-promising research focusing on eliminating brain plaques thought to cause dementia have, unfortunately, not produced effective treatments.
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The Hollywood Chamber of Commerce administers the hundreds of star plaques on sidewalks in the Los Angeles neighborhood.
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The wood-lined walls of the room were decorated with a portrait of Overton and various commemorative plaques.
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Plaques commemorating gold and platinum records—often found in corner offices at major labels—hang in the bathroom.
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The drug works by attacking the stringy amyloid tendrils that form before they begin sticking together into plaques.
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Many like Hussle earn a healthy living, if not ultra-wealth, without broad radio play or platinum plaques.
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The doors had been left open, and no markers or plaques indicated the historical significance of the structure.
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In 2003, Cousy sold his memorabilia for $450,000 —— trophies, plaques, scrapbooks — and gave the proceeds to the daughters.
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Those artifacts — mostly sculptures and relief plaques — were looted from royal palaces during a British expedition in 1897.
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Heavy wooden pews gleam with brass plaques bearing the names of Jewish families since scattered across the world.
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The drug clears a key protein in Alzheimer's disease — beta amyloid — that accumulates in plaques in patients' brains.
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There is no way to predict which of those plaques will break open and cause a heart attack.
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A series of tall, signboardlike plaques in the galleries list the names of thousands of black lynching victims.
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Coffin plaques have yielded the names of just three people: Thomas Weir, Mr. R. Watson and Benjamin Britton.
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Drugs reducing the existence of these plaques are one of the big goals to provide an effective therapy, and Biogen's trial on patients with mild or presymptomatic Alzheimer's disease saw a statistically significant reduction in these plaques, as well as a slowing of mental decline, at the 12-month mark.
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In essence, these results suggest that large amounts of exercise can up someone's risk of developing plaques, while also lessening the likelihood that he will die from a heart attack precipitated by those plaques, says Dr. Laura DeFina, the chief science officer for the Cooper Institute, who led the study.
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The people, the noise, the endless unveiling of small brass plaques; it would try the patience of a clam.
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The researchers found plaques of a protein called beta amyloid, along with the tangles of another protein called tau.
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When compared to a control group, the dosed mice had less inflammation, less plaques, and even improved neuron growth.
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Dr Miller and his colleagues thus wondered if their particles were being carried specifically to those plaques by macrophages.
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The volunteers carried gene mutations that cause an overproduction of amyloid, which accumulates in hard plaques in the brain.
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And the town is trying to create a "history trail" with blue plaques—if it can find enough history.
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Broadly speaking, the theory was that those plaques cause Alzheimer's, and that an effective treatment would break them up.
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Plaques rupture in the manner of a pimple, and this is what can cause a heart attack or stroke.
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Throughout this week, the European country plans on remembering the victims with memorial plaques, eulogies and other public ceremonies.
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One suggestion as you reported is to add plaques to them explaining their background ("Recast in stone", February 6th).
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The Herald reported his Miami office is filled with plaques of appreciation from city leaders, activists and church elders.
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I inspected life-size models of his various DDEs, with plaques affixed describing which Apollo mission they flew on.
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They hoped to develop a drug that would target the misfolded PrP protein, stymieing plaques before they could form.
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BAN2401 demonstrated a dose-dependent reduction in amyloid plaques that was statistically significant at all doses tested, researchers said.
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In one study, the group injected Salmonella bacteria into the brains of young mice that did not have plaques.
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The two copies of APOE3 Christchurch apparently protected her mental abilities despite all the amyloid plaques, the researchers say.
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Specifically, he was asked about a decision by a Virginia church to remove plaques celebrating Lee and George Washington.
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The plaques were hung on either side of the altar inside the church in 1870, shortly after Lee's death.
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Emily Bryan, Senior Warden of Christ Church, spoke to congregants about the decision to remove and relocate the plaques.
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Like Pokémon GO, Ingress uses real-world landmarks (things like statues, towers, plaques or murals) as important gameplay spots.
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Every wall and table is covered with photographs, gold records, awards plaques, art and posters from his many movies.
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The conservancy said the grove was vandalized in 1960, and 11 of the commemorative plaques by the trees disappeared.
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The rare genetic mutations led to an overproduction of amyloid, it turned out, the abnormal protein in those plaques.
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He had long been fascinated with the plaques on benches in Central Park and liked how they seemed egalitarian.
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A. Yes, lifestyle changes, including diet, smoking cessation, stress management and exercise, can decrease the size of atherosclerotic plaques.
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Originally, the library was named after the nearby church, St. Deiniol's, which contains several plaques commemorating the Gladstone family.
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Inevitably, there will be slumps and adjustments, as there are for all players, even those with plaques near Oneonta.
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To confound matters, even the assumption that plaques and tangles cause the symptoms of Alzheimer's is now being questioned.
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As "Silent Night" plays softly over loudspeakers, guests pass plaques featuring the lyrics to the song in various languages.
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But their example offers lessons for families without famous last names, philanthropic resources and numerous plaques in their honor.
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Comparing the groups, the researchers determined that the men in the highest-exercise group were prone to developing plaques.
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The plaques now say that from the early 1800s, through generations, the Zimmermann family produced and traded wines in Tokaj.
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She told Motherboard in an interview that amyloid plaques can appear in the back of the eyes on the retina.
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The dividers, plaques, and jerseys are most notable for their lack of team specificity and overbearing abundance of sponsorship logos.
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Today it is an eerie site: part town and part ghost-town, walls speckled with commemorative plaques, train tracks overgrown.
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Users from all across the country have already identified almost 200 Confederate monuments, statues, plaques, and memorials in 20 states.
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Volunteers erect plaques at the final known addresses of those who were arrested in the Stalin years and never returned.
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To her, paywalls began to seem like the plaques in an Alzheimer's-riddled mind, clogging up the flow of information.
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"The hooker in this whole thing is you can have individuals loaded with plaques that are cognitively normal," he said.
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Christie's June 3 sale of Russian Art in London sold £16,172,688 worth of paintings, design work, plaques, and other formats.
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Alzheimers is characterized by a buildup of two proteins, tau proteins inside of neurons and amyloid plaques on the outside.
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County leaders then decided to cover the old racial inscriptions with plaques denoting the year the courthouse was built, 1908.
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In "Osiris, Osiers" (1983), made with David Ballantyne, we see two similarly sized brown ceramic plaques mounted on the wall.
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At the three drill sites we've installed bronze plaques that reveal the geologic histories and nonhuman stories of the area.
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"Don't be fooled by the plaques that we got, I'm still, I'm still Alex from the Bronx," Ocasio-Cortez tweeted.
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There had been discussions about relocating the plaques in the past, for reasons that include their lack of religious purpose.
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The first floor was boarded up, but two plaques, one metal, one stone, were embedded in the sidewalk before it.
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Psoriasis causes an overproduction of skin cells, resulting in inflamed, red lesions or plaques, which can be itchy and painful.
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Amyloid plaques and Tau tangles—the pathological hallmarks of the disease—can be observed 20 years before actual symptoms appear.
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Her mother, Barbara, had an eye for details and noticed the plaques, one on either side of the revolving doors.
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Some of the metal was used to make small H-etched plaques for the dials of the company's Premiere wristwatch.
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Dr. Tanzi describes this as "seeding" the amyloid, causing it to ensnare the virus in fibrous nets that form plaques.
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During Labor Day weekend, I was walking around Central Park playing a game with the memorial plaques on the benches.
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There are plaques, like one he received when he was inducted into the Nicaraguan Sports Hall of Fame in 2000.
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For a few years, the Hall of Fame had an awkward habit of reaching for nicknames to put on plaques.
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Plaques that once memorialized the 1932 coup that abolished the absolute monarchy have, according to some Bangkok residents, simply disappeared.
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On Tuesday, French President Francois Hollande visited the site of the attacks and unveiled several memorial plaques to the victims.
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The tests revealed that the women who were postmenopausal had less brain activity and more Alzheimer's plaques than premenopausal women.
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They analyzed their spinal fluid for the presence of indicators of the plaques and tangles that are characteristic of Alzheimer's.
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And the lower the LDL level for the evolocumab patients went, the more likely it was that plaques would shrink.
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Conversely, a study of female marathon runners found that they had less evidence of coronary plaques than their sedentary counterparts.
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How 'bout voting in Bonds and Clemens and including a blip about their alleged drug use on their bronzed plaques?
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The sale's top lot, a massive pair of painted enamel plaques from the Qianlong Period (1736–95), sold for $150,000.
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Turnher certainly agrees, #AVNsSoWhite holds a hell of a lotta truth ... but he's got his mind on cash, not plaques.
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But we took them and ended up giving the plaques to Nana, though she never mentioned what she did with them.
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The presence of these plaques sets another process in motion, whereby another protein, called tau, forms tangles that destabilize brain cells.
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Interestingly, traces of amyloid beta were higher in chimp blood vessels than in plaques—that's not what typically happens in humans.
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They said once brain plaques can be observed it may already be too late for the drugs to provide significant benefit.
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Few experts want to give up on the hypothesis that amyloid plaques in the brain are intimately involved in Alzheimer's disease.
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" She added, "The person [selling the house] hid all the plaques in the garage so he would still buy the house.
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There are dozens of plaques across town, each commemorating a chunk of a place that trades on its history and immutability.
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" She added: "The person [selling the house] hid all the plaques in the garage so he would still buy the house.
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" Marcucci's official title, on the plaques accompanying each artwork on view on the 69th floor, is "Executive in Charge of Production.
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In a clinical trial, an antibody-based drug for Alzheimer's shrank disease-associated protein plaques in the brains of many patients.
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For years, researchers had been fixated on the idea of plaques as a sort of trash that gathered in the brain.
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Plaques feature descriptions of each exhibit, leaving visitors both entertained and informed by giving them context for what they're looking at.
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Chapel Hill Mayor Pam Hemminger said Friday that the plaques were temporarily moved due to public safety concerns surrounding the protests.
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Dozens of lawmakers also received awards or plaques as part of the more than 1,300 individual expenditures listed in the reports.
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The sisters proudly point to dozens of plaques and certificates of appreciation from the N.A.A.C.P., the City Council and other organizations.
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The only exception is that officers are allowed to accept pen and pencil sets, plaques or other common tokens of appreciation.
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A collection of 15 NASA astronaut hand casts, originally used to tailor-make spacesuit gloves, mounted on plaques and decoratively gilded.
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We urged that Confederate monuments be supplemented with plaques that clarified their historical evasions, Jim Crow origins and white supremacist function.
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If people take statins their calcium scores go up because statins help plaques heal and leave behind calcium-containing scar tissue.
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They attend the evangelical Church of Christ twice a week and fill their home with plaques of prayers and inspirational sayings.
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Here's a list of every monument—from small plaques to imposing statues—local municipalities are removing following the turmoil in Charlottesville.
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After I asked Rubino about the plaque's origins, we ended up chatting for a while, as fellow plaque aficionados, about plaques.
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Drinking alcohol moderately is associated with lower levels of a protein that forms Alzheimer's brain plaques, according to a new study.
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The Brooklyn plaques were attached to a tree outside St. John's Episcopal Church in the Fort Hamilton section of Bay Ridge.
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The first pathological changes in the brain, the amyloid plaques, appear up to 20 years before there is any cognitive impairment.
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Flanked from the front and behind, they pass by wall plaques commemorating past and recent Jewish victims of Palestinian knife attacks.
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Though most people rarely enter cemeteries, are their contents — statues, monuments and plaques — subject to scrutiny by people in the community?
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Explorers claimed immense territory for Catherine the Great by burying metal plaques, reminiscent of Soviet pennants later left on the moon.
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The bronze plaques like the ones at the British Museum served as records of rites and documents of visits by dignitaries.
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In the last 50 years, that tablet has been filled, as was a second one, along with several other side plaques.
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Plaques got smaller in two-thirds of those taking evolocumab but in fewer than half of those taking a statin alone.
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So you're designing at the hotel wallpaper and "Do not disturb" hanging plaques and things that people live and interact with.
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Ms. Folt had requested the removal of the statue's base, which included plaques memorializing university students who fought for the Confederacy.
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These activated immune cells infiltrated blood vessels early in the course of coronary disease and enabled plaques to grow and rupture.
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The Alley is packed with murals and stone-and-metal plaques inscribed with poetry by Kerouac, Ferlinghetti, John Steinbeck and others.
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And as I wander through, I try to look at the plaques that seem to be placed in front of each missile.
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But in Alzheimer's patients, it clumps together to form the plaques that are thought by many experts to slowly destroy the brain.
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Aducanumab is tailored to bind to a protein called beta-amyloid, which forms plaques in the brains of people with Alzheimer's disease.
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Two plaques in Compiègne's station list the 23 locals killed in the first world war and the 20 killed in the second.
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At Rago auction house, the foundation has paid six-figure prices for plaques made in the 1910s that depict peacocks and fish.
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Instead of waiting for brass plaques and new signage, some have taken it upon themselves to change the signage around the building.
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Commemorative plaques at 601 Montgomery Street in San Francisco mark the former headquarters of the firm that owned and operated the service.
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And across Britain, heritage plaques on Georgian townhouses euphemistically describe former slave traders and slave owners as West Indies merchants or planters.
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" But the members tell me that when you look at the plaques on Trump's locker there, it says: "2018 Men's Club Champion.
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Over time, a high heart rate many hours a day may cause plaques to form in the arteries, Allesoe said by email.
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Lucious blows up the pictures and arranges them in the studio on life-size glass plaques, like a personal art museum/memorial.
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But there are no identifying signs; the sole information divulged is on brass plaques that bear the street name and building numbers.
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Random sections of the wall still exist in and around the city, as do "Berliner Mauer 1961-1989" plaques in the pavement.
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The condition is believed to be caused by a buildup of beta amyloid plaques and neurofibrillary tangles called tau in the brain.
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The consequent changes inside blood vessels can prompt plaques there to rupture, cutting off blood flow and causing the actual heart attack.
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Biogen is racing to complete Phase III trials of aducanumab, which is designed to clear beta amyloid that has already formed plaques.
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The disease is thought to be caused by a buildup in the brain of beta amyloid plaques and neurofibrillary tangles called tau.
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Martin's Tavern actually has a 'Ty Cobb' salad on the menu: Martin's Tavern has plaques commemorating famous baseball players including Ty Cobb.
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The rest had some deposits, with 12 displaying slight amounts, another 12 moderate levels, and 10 having worrisomely large deposits of plaques.
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If she needed to catch her breath while walking into work, she pretended that she was reading the plaques in the hallway.
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The guilt had to do with two plaques at Lord & Taylor and a promise to her mother that she did not keep.
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The national debate about monuments, plaques and memorials has often centered on Confederate figures like John C. Calhoun and Robert E. Lee.
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A new study links daytime sleepiness with the accumulation of the plaques in the brain that are a hallmark of Alzheimer's disease.
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Mr. Cuomo's request to the Army also came on the same day that a Brooklyn church removed two plaques that honored Gen.
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A plaque bearing his name hangs in the school's front hallway, alongside plaques for Ruth Bader Ginsburg, Judge Judy, and Carole King.
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Microglia are the immune cells of the central nervous system, clearing the brain of plaques, unnecessary neurons and infectious agents like bacteria.
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It stimulates neural activity and may help prevent the build up of plaques that are connected to the onset of Alzheimer's disease.
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Ask Well Q. Is it possible to remove plaques in your aorta or reduce their size through changes in diet or lifestyle?
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Such plaques are worrisome, since if they break free from the artery walls, they can block blood flow, causing a heart attack.
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Each floor's hallway was decorated with artsy black and white photos of famous Manhattan parks, with informational plaques providing tidbits of history.
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The disease is thought to be caused by a buildup in the brain of beta amyloid plaques and protein tangles called tau.
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It finds that middle-aged men who work out often and vigorously do tend to develop worrisome plaques in their cardiac arteries.
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LONDON — Visitors to London will invariably notice ceramic blue plaques dotting facades of houses and buildings in honor of famous former residents.
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Some of her cryptic poems are displayed on plaques which border a garden leading to the central fountain in City Hall Park.
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Entering the exhibition area, I walked alongside a curved wall decorated with plaques and raised letters saluting the long list of private donors.
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Matthews International is a publicly traded company that specializes in cemetery products, ornate engravings and manufacturing cast bronze plaques for memorials and monuments.
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Along the walls are vibrant plexiglass plaques and a row of color coordinated sports jerseys, raised high like relics of a championship run.
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Memorial plaques and interpretive signs at the state park mark the trail leading to the site, surrounded by rock walls and chain link.
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Crenezumab, which AC Immune licensed to Roche Holding AG's Genentech division in 2006, targets protein plaques found in brains of patients with Alzheimer's.
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Researchers suspect the unusual plaques and tangles may be causing the disease or at the very least contributing to the death of cells.
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Lilly's setback raised questions in the strategy of targeting the beta amyloid protein, believed to cause brain plaques, which Biogen's aducanumab also targets.
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History hides in plain sight; blink and you might miss the explanatory signs hanging on poles and historic plaques on sides of buildings.
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"The prosthetic guys did mount the horns on two plaques for me at the end of the production, which was nice," Stevens said.
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Recent research points to tau-tangle accumulation as a possible step beyond amyloid plaques in the development of actual signs of Alzheimer's disease.
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Wells' life was remembered locally mostly by out-of-the-way plaques, the kind you see at a glance from a car window.
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Cities across the United States are debating what to do with hundreds of statues, plaques and other monuments to the slave-holding Confederacy.
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"Basically when we do message plaques, we're doing them for ourselves—we're not doing them for aliens," she told me over the phone.
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Inside the brain, Alzheimer's is associated with abnormal clumps known as amyloid plaques and tangled bundles of fibers, often called tau or tangles.
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The app led me to easily overlooked architectural details like the three circular plaques located above Radio City's famous facade on 50th Street.
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It would take another 80 years for scientists to identify what those deposits were: plaques and tangles of proteins called amyloid and tau.
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But I wondered then and now about the history of those smaller places we had passed through with no plaques to speak of.
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Even though I'd walked over these plaques hundreds of times over the years, I'd missed quite a few of them, like this one.
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Men over age 55 with longer histories of psoriatic arthritis were more likely to have the plaques most commonly associated with heart problems.
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The future spreads before the four of them now, pure and unspoiled, parades and Cy Young Awards, nine-figure contracts and Cooperstown plaques.
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While some people erect plaques, statues or buildings to remember a loved one who has died, others start foundations, scholarships or memorial funds.
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The park is a sort of mass market for historical markers — 29 statues, along with multitudinous plaques, busts, carved panels and memorial groves.
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A movie set designer by trade, Mr. De Camillis also designed one of the numerous plaques that track Pasolini's life in the neighborhood.
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She and her husband used discarded squares of marble from finished architectural projects to make decorative table number plaques and seating number assignments.
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"His idea of 'proof' is picking up awards in Kankakee or Sheboygan and using these plaques he got as evidence," Mr. Kimball said.
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At 12 points on the sidewalk, along what would be frets on a guitar neck, plaques embedded in the concrete narrate Hendrix's life.
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The results were even more surprising given the poor track record in Alzheimer's drug development, including trials of medicines that target amyloid plaques.
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She'd had a heart attack, the doctors said, but it wasn't from atherosclerotic plaques narrowing her vessels with layers of fat and crust.
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Plaques on the risers of the steps leading from the subway to the street list the names of the businesses that were destroyed.
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The excess can back up in the arteries and create plaques that hinder blood flow, leading to strokes, heart attacks and heart disease.
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The wall behind him carried plaques dedicated to old customers and an early framed menu from when steaks "broiled or chopped" cost $4.50.
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I looked around at the statues, plaques, and pillars, the stained-glass windows, and then I went to the altar rail and knelt.
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The Hotel's main entrance is located on 41st Street, known as "Library Way," and features 100 bronze plaques emblazoned with famous literary quotes.
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A historic Episcopal church in Alexandria, Va., has made the decision to move a pair of plaques that paid tribute to Confederate Gen.
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The plaques honoring Lee and Washington, who were former parishioners, were displayed on either side of the altar at Christ Church in Alexandria.
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Now researchers have found these five risk factors correlate with the development, years later, of amyloid brain plaques, a hallmark of Alzheimer's disease.
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Jeter's actual plaque, which is the 44th to be installed, including seven monuments and several more plaques for non-Yankees like Nelson Mandela, Jackie Robinson and two popes, was manufactured by United States Bronze in New Hyde Park, N.Y. Wall space is at a premium in Monument Park, but Behar said no plaques would ever be moved to accommodate new ones.
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Some University of North Carolina students celebrated the plan to take away the pedestal and plaques on Monday, according to Raleigh television station WTVD.
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The company licensed its investigational drug, crenezumab, to Roche a decade ago to target protein plaques found in brains of patients with Alzheimer's disease.
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Chris, 32, has a an egg-sized boil smack dab on the top of his head, and severe psoriasis plaques over his whole body.
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Beta-amyloid and tau are naturally occurring proteins in the brain that clump together in people living with Alzheimer's, forming plaques and tangles respectively.
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By the time symptoms like memory loss and confusion show up, a person's brain is littered with fiber-like plaques made of amyloid beta.
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Many dementia patients in previous trials later proved not to have the amyloid plaques the experimental drugs targeted, greatly increasing the likelihood of failure.
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AC Immune a decade ago licensed its investigational medicine crenezumab to Roche to target protein plaques found in brains of patients with Alzheimer's disease.
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"I look for new animal research in newspapers, subscribe to wildlife journals, and visit zoos and taxidermy museums to read the plaques," said Barker.
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Between the lines: Most Alzheimer's research to date has focused on a protein called beta amyloid, which forms large plaques on Alzheimer's patients' brains.
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He noted solanezumab was being studied in a separate trial called "A4" among people with no Alzheimer's symptoms but who have the brain plaques.
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So scientists and pharmaceutical companies have pinned their hopes on drugs that can break up these plaques or prevent their accumulation in the brain.
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Pennsylvania Officials with Gettysburg National Military Park said they have no plans to remove any of the park's 18953,300-plus monuments, markers or plaques.
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He examines the blood vessels, looking for yellow buildups of fat, or plaques, that might be present in a person with high blood pressure.
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Two months later, their brains are riddled with amyloid beta, the protein "plaques" that also characterise the latter stage of the disease in humans.
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There are plaques, but no extant homes, to show for Mozart's first two addresses, at Singerstrasse 13 and Milchgasse 1 beside St. Peter's Church.
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Irreversible after it begins, it's thought to be caused by a buildup in the brain of beta amyloid plaques and neurofibrillary tangles called tau.
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One widely believed theory is that the disease is driven by the production and deposition of beta-amyloid plaques between neurons in the brain.
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The most promising evidence points to cannabinoids reducing the formation of plaques in the brain associated with inflammation and higher rates of cell death.
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Dozens of false facades were added to Communist-era buildings, while scores of plaques appeared, attesting to events with varying degrees of historical accuracy.
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There are also photographs of Braves Field and its players and plaques commemorating the original stadium in the hallway underneath Nickerson Field's main stands.
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This year, uniformed cadets marched for the first time in the Charleston Pride parade, and plaques around campus designate "safe zones" for L.G.B.T. students.
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The most famous items are 20163 brass plaques, dating mainly from the 16th and 17th centuries, once nailed to pillars in Benin's royal palace.
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Mr. Robertson urges the British Museum to give back to Nigeria the Benin Bronzes — sculptures and relief plaques looted during an 1897 British expedition.
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"All these plaques are to celebrate our diversity," Vilnius Mayor Remigijus Simasius told Reuters as he unveiled a street sign in Hebrew and Yiddish.
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The two plaques honored students and alumni who died fighting for the Confederacy in the Civil War and will be moved to another location.
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Cardiologists know that if plaques are dense and heavily calcified, they tend also to be stable and unlikely to break free from artery walls.
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But in both studies, the more active someone was, the more likely that his (and in rare instances, her) plaques were calcified and dense.
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"But if you dig into the morphology of the plaques," he continues, "they appear to be more benign" than in people who exercise less.
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Studies have shown that sitting motionless reduces blood flow to the legs, increasing the risk for atherosclerosis, the buildup of plaques in the arteries.
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One candidate might be the astrocytes, cells that support the neurons and synapses, keeping them healthy even in the presence of plaques and tangles.
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On a recent Saturday night, one such woman pulled out a stool for a tipsy wallflower diligently reading plaques describing the studio's glamorous history.
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The plaques are one of three memorials at Mount Mitchill, a park in Atlantic Highlands, dedicated to reflection and remembrance of the day's events.
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When amyloid protein is misprocessed, it begins to accumulate in the brain, forming a sticky buildup outside the nerve cells called beta-amyloid plaques.
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Alzheimer's disease, which is believed to be caused by a buildup of plaques and tangles in the brain, is the most common type of dementia.
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Raghanti said it's not clear if the plaques and tangles found in chimps are producing the same level of cognitive decline as seen in humans.
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Surrounding this participatory sculpture are works from the Tranny Tease series: vacuum-formed plastic plaques decorated with text and iconography from various languages juxtaposed together.
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The walls of his third-floor office lack the usual commemorative plaques, framed medals and challenge coin displays that are typically found within the building.
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So then there's Kanye, who lands the best line, "trade my Grammy plaques just to have my granny back" and laments the dangers of Hollywood.
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In recent years, though, there's been research showing that while the accumulation of amyloid beta can cause Alzheimer's, it's not actually doing damage through plaques.
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One successful strategy has been a "Name a Chair" program, for which they sold plaques on 70 chairs in the new theater for $1,000 each.
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Studies have shown that as these conditions progress, these proteins tend to form clumps (known as amyloid plaques and tau protein tangles) in the brain.
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The tears kept coming later on stage as the two joined co-writer Jesse Frasure, all dressed in party-themed onesies, to accept their plaques.
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A few studies in cognitively normal people and one in mice have shown a connection between chronic sleep disruption and the development of amyloid plaques.
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It also recommends erecting other features, such as sculptures or plaques, to provide additional context about the Hamburg Massacre, Reconstruction and the Jim Crow era.
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Called NaturArte Project, it lines Praiano's streets with ceramic plaques and sculptures, creating a kind of open-air museum that unfolds along eight different routes.
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One of the plaques next to his statue in Central Park read, "His brilliant achievement carried the fame of American surgery throughout the entire world."
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There are blurry videos online that seem to show it mostly empty save for two pillars, an altar, incense lamps and plaques on the wall.
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Moderate alcohol consumption is associated with reduced levels of beta amyloid, the protein that forms the brain plaques of Alzheimer's disease, a new study suggests.
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The building's name is a reference to a pre-Revolutionary War farm found in the area, but the name survives mostly only on plaques today.
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In Brooklyn, the plaques had become an "offense to the community" and an emblem of ideas that are "antithetical to the Gospel," said the Rev.
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For the plaque, there is ample space beside the plaques for Yogi Berra and Posada along the back wall of Monument Park, near the entrance.
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John Nolan, a truck driver from Nashville, gazed at all the plaques and monuments squeezed into the park, which sits beyond the center-field wall.
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If, on the other hand, the plaques are fatty and somewhat loose, they can more easily rupture from the wall and initiate a heart attack.
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The four female plaintiffs — Aurelia Browder, Claudette Colvin, Susie McDonald and Mary Louise Smith — are each honored at the site with plaques reading their names.
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Researchers have learned that a patient with a narrowed artery may have plaques not just in a single blocked area, but throughout the coronary arteries.
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The display is devoid of context and overwhelming, so I turn to my left and approach a nearby wall filled with plaques and framed photographs.
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On the wall a dozen plaques from the Specialty Coffee Association of Europe certify her proficiency in skills ranging from roasting beans to serving the drink.
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In healthy brains, amyloid beta breaks down and goes away, but for people with Alzheimer's, this protein lingers, resulting in the formation of plaques between neurons.
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For all of the heights we have achieved as a people, humanity still can't seem figure out this whole Memorializing People on Plaques and Statues thing.
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Tearing apart the tangles Although they may be talked about more often, plaques are not the only theory among scientists to explain how Alzheimer's disease occurs.
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Scientists have tried to create drugs that delay or prevent Alzheimer's by clearing away these plaques, but the clinical trials of these treatments have abysmally failed.
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French President Francois Hollande unveiled memorial plaques to the victims Tuesday while candles and flowers have been laid by the public at the Charlie Hebdo offices.
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Most researchers agree that these plaques are at least part of the cause of Alzheimer's symptoms, rather than being a benign consequence of other, harmful processes.
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" It gets even crazier, she said, laughing, "The person [selling the house] hid all the plaques in the garage so he would still buy the house.
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It's long been assumed that if we can stop these deposits, particularly plaques, from happening or break them up, we can delay or outright prevent Alzheimer's.
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Such changes in blood flow could cause fatty buildup in blood vessels called plaques to loosen, leading to dangerous blood clots in the heart or brain.
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Instead, participants who reported eating seafood at least once a week were less likely to have hallmarks of Alzheimer's disease, including amyloid plaques, in their brain.
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It is designed to prevent a protein called beta amyloid from forming plaques in the brain, which is believed to play a pivotal role in Alzheimer's.
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The law instructs the government to take measures to remove shields, insignia, plaques and other objects or mentions commemorating the military uprising, civil war or dictatorship.
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More recently, the five women were also presented with plaques from the families of victims of police violence, including Sybrina Fulton, the mother of Trayvon Martin.
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There, inside several plastic tubs stacked in a far corner, were the trophies and plaques that state her case as the world's best female duckpin bowler.
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Irreversible once it begins, the disease is thought to be caused by a buildup in the brain of beta amyloid plaques and neurofibrillary tangles called tau.
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Seats at the bar will be adorned by inlaid brass plaques bearing the names of famous Havana visitors like Ernest Hemingway, Al Capone and Alec Guinness.
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Brain pathologies include the protein plaques and tangles seen in Alzheimer's disease, as well as the infarcts (small areas of dead tissue) seen in cerebrovascular diseases.
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Its white walls were full with rose and blue silk flowers and tribute plaques to the village's dead, including members of the star-crossed Cañadas family.
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Between this and accidentally emailing the very company that makes the official plaques, it felt destined, a small price to pay for New York City history.
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A city of 223,000 people, Richmond was the former capital of the Confederacy, and its streets, public plaques, and monuments reflect the history of the period.
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He walked around the conference room of Le Bernardin, pointing out untidy piles of books, guides and plaques that had accumulated while she was in Mustique.
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Apparently, the temple employed artisans who mass-produced some of the offerings: small, thin bronze plaques of body parts crudely hammered on demand for the pilgrims.
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In the 2500s, the British Museum sold several plaques to Nigeria for a planned museum in Lagos, for instance, and sold others on the open market.
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This year, it was revealed that only 4 percent of London's Blue Plaques commemorate black or Asian individuals, and just 13 percent are dedicated to women.
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The relative importance of the two was disputed, but many scientists concluded that those plaques and fibrils clog the brain as coffee grounds clog a drain.
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The government representative in Vilnius region Vilda Vaiciuniene said the plaques violated a law requiring all official names to be in Lithuanian, and must be removed.
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" Anthony Savicke, a vice president of the Bay Area Sports Hall of Fame, told The Mercury News that the images on the plaques were merely "representations.
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For his values and commitment he paid with his life in 2012; his name is now on one of those plaques in the C Street lobby.
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Create personalized cards, mugs, canvases, plaques, pillows, frames, wind chimes, blankets, *takes a breath* and a whole lot more we don't have the energy to list.
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Exhibiting them all in museums is unfeasible, and in certain cases the best option will be to contextualize them in place through well researched explanatory plaques.
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During the intermission, Cisneros stands in the center of the cage to present plaques honoring a number of war vets and their families for their service.
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Researchers have been especially focused on finding a drug that could erase amyloid plaques, and we now have dozens of compounds that do that in mice.
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The plaques have been placed (well, two of them; the other two are awaiting some final arrangements), the audio's been edited, the map has been made.
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In the case of this work, I set out to create a concrete final product: four cast 12" x 15" aluminum historic plaques with bronze finish.
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Plaques, the blandest, most everyday form of sharing historic knowledge, can be an interesting format in which to present information that's usually lost or kept secret.
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Scrolls and plaques, also with inscriptions, hang by hooks from the tree trunks, and in front of each tree is a curious, symmetrical landscape, perhaps a cemetery.
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Researchers have long speculated that plaques, and to a lesser extent tangles, are primarily responsible for the damage Alzheimer's causes, but not everyone agrees with that explanation.
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So far, users from across the country have listed nearly 2100 Confederate monuments, statues, plaques, and memorials in 217 states including Arkansas, Florida, Georgia, Texas, and Virginia.
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Waheire said he'd toured national monuments to victims of repression in South Africa, Argentina and Germany and had been especially moved by the plaques with people's names.
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It says it plans to deliver "plaques of honour" to the homes of all acting and demobilised soldiers, one simple way of making them feel more appreciated.
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This particular trio were asked to breathe in the gold dust 24 hours before they underwent surgery intended to clear their plaques and unblock their constricted vessels.
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Some may be experiencing the subtle signs of cognitive loss; others are still blind to growth of the devastating plaques and tangles destined to steal their memories.
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There was no network coverage of how Alexandria, Va.'s historic Christ Church was removing two plaques that had been in the church for nearly 150 years.
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I mean, you have the [monuments], the Stolpersteine ["stumbling blocks"—bronze plaques in the ground in front of buildings with information about each Jew who lived there].
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Church leaders will create a committee of parishioners to explore options for displaying the plaques "prominently and with appropriate historical context on our campus," the letter says.
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Noelle York-Simmons, rector of the church, told The Associated Press Sunday that conversations had been going on about the plaques for at least a few years.
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The drug was designed to clear the amyloid plaques long believed to play a role in the incurable disease, which slowly robs people of their mental abilities.
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The person who chooses who does–and does not–get one of these coveted plaques on the world-famous sidewalk is a diminutive Latina named Ana Martinez.
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Brett Eldredge has earned his share of plaques for going No. 1 – but never quite like the one he received on Thursday from his Nashville recording company.
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And some pranksters even installed commemorative plaques at the McDonald's location where Prime Minister Morrison allegedly defecated in his pants, or "shit his dacks" in Australian parlance.
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These desk plaques look just like the ones from the '80s and read "Boss Lady" or "Get It, Girl" — perfect for making a statement at the office.
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Though the official plaques say white miners "struck it rich" at Granite City in 1885, there's evidence Chinese miners were already working there for 25 years before.
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At his home in Gallarate, police found nine assault weapons, nearly 30 hunting rifles, pistols and bayonets as well as ammunition and antique Nazi plaques featuring swastikas.
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Most efforts to modify the disease mechanism so far have tried to counter the buildup in the brain of beta-amyloid, a protein that forms sticky plaques.
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This is not the sort of greatness that's easily quantified, or that is summed up neatly on Hall of Fame plaques or the backs of basketball cards.
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A few feet away, Cécile is hard at work with six Krampouz billigs, the nickname given to the traditional circular plaques used to cook crêpes and galettes.
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Janet Scudder distinguishes herself with two small, low-relief plaques, both cast in silver, and with a bronze sculpture in the round (all from the early 1900s).
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The resentment fueled his ambition, and he took a certain satisfaction, on high school awards nights, in bringing his father the trophies and plaques he had won.
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So in August 2015, her mother decided to send a letter about the plaques to Hudson's Bay, the Canadian retailer that had acquired Lord & Taylor in 2012.
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The spokeswoman for Hudson's Bay, Tiffany Bourré, said the plaques would be preserved and taken care of after the store closes for the last time on Wednesday.
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An average of 15 years later, researchers administered PET and M.R.I. scans to detect the presence of beta-amyloid, the protein that clumps together to form plaques.
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We have very wealthy donors who would pay for bronze plaques explaining who these men were, what they fought for, what happened to try to educate people.
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I waited on a sofa, under some framed posters of the Rocky Mountains and a couple of AAA plaques affirming the cleanliness of the Manor House Motel.
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What struck me about the graffiti — preserved behind glass and with plaques describing who likely created them and what they were about — was how intricate they were.
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In healthy brains, amyloid beta breaks down and disappears, but for people with Alzheimer's, this protein refuses to go away, resulting in the formation of plaques between neurons.
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If you take Alzheimer's disease as an example, there has been for decades debate as to whether the plaques are a cause or a result of the disease.
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Even if some researchers believe plaques and tau proteins may not play a causative role, they are considered hallmarks of the disease that diagnostics work is built around.
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When scientists look at tissue from an Alzheimer's patient's postmortem brain, they see not only the unusual plaques and tangles but also surprisingly few brain cells and synapses.
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Campaigners have vowed to continue their protest with stone plaques, which mimic the ritual of placing a large stone in the ground after a person has been buried.
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Furthermore, the museum's website and the plaques at the entrance to the Sackler Wing rooms still carried the family's name just a few weeks ago, PAIN Sackler says.
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The most widely endorsed theory of the disorder is that beta amyloid is the principle bad guy, in part since plaques seem to show up before tau tangles.
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Janet Conrad's office is full of books and plaques, scientific models and toy demos—exactly what you'd imagine an MIT nuclear physicist's base of operations should look like.
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There's even growing evidence that poor sleep early in life can lead to the development of the plaques and tangles that cause Alzheimer's and other kinds of dementia.
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Its abundance of plaques, murals, and pocket parks mean you'll find pokéstops practically every block, and its pokémon population can feel almost as dense as its human one.
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By no means modest, the St. Paul homes that bear plaques stating that the city's favorite son once lived there would make any passer-by stop and look.
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The announcement took place in the rotunda of Nashville's Country Music Hall of Fame and Museum, the home of the 127 plaques that honor Hall of Fame members.
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Older studies ultimately found that a number of patients tested did not actually have the clumps and plaques the drug was targeting, which might help explain failure rates.
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So if you're a Mets fan strolling through the gallery in Cooperstown, N.Y., this weekend, try a scavenger hunt for the 19653 other plaques that acknowledge your team.
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Researchers find signs of Alzheimer's in dolphin brains Later research identified the proteins that made up the plaques as amyloid and those that form the tangles as tau.
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Those causes are brain infarcts (also called brain lesions) and the signature biomarkers of Alzheimer's disease: the plaques and tangles, both made of different proteins, in the brain.
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These range from conventional bronze plaques to more ambitious examples of public art like stone monuments, sited in barren stretches of wilderness, populated city centers, or even underwater.
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There are exhibits devoted to their manager's business acumen, their stage costumes, their multitudinous Gold and Platinum plaques, their microphones, their studio setup, and their pre-show ritual.
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After controlling for other variables, they found that compared with people who reported no daytime sleepiness, those who did had almost three times the risk of having plaques.
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She also directed that a portion of the money be used for something else: the maintenance of the plaques the charities would install in recognition of her donations.
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But they also want to control tomorrow, to chisel the story of their lives into plaques and cornerstones before some historian can overwrite them with an uglier truth.
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Tiny $150 jars of face cream are backlit for effect; metal plaques next to miniature bowls of green tea and ginseng extol the wondrous properties of the ingredients.
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This year, London celebrates 150 years of Blue Plaques: these tiny, ceramic homages to London's greatest and most eccentric — and on rare occasion, most achingly virtuous — city dwellers.
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The University of Virginia will remove two plaques honoring Confederate soldiers and ban open flames on campus after white supremacists marched on the campus with torches last month.
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Legend has it that he wrote "The Raven" at a farmhouse near 84th Street and Broadway, where today a pair of dueling plaques lay claim to the author.
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Mark Bradford, the renowned Los Angeles artist, says Confederate statues should not be removed unless they are replaced by educational plaques that explain why they were taken away.
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Of course, these studies cannot tell us whether people's exercise habits directly cause plaques of any kind to develop in their hearts, only that the two are related.
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So a Lautner aficionado arriving one recent evening might have been surprised to see men wearing Looney Tunes jerseys and track suits covered in trompe-l'oeil gold plaques.
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This test uses a CT (computed tomography) to look for the buildup of calcium plaques on the walls of the coronary arteries, which supply blood to the heart.
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The chancellor, Carol L. Folt, said on Monday she had authorized the removal of the statue's base, which bore plaques commemorating university students who fought for the Confederacy.
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That 2013 resolution prohibits cities or counties from relocating, removing, altering, renaming, or rededicating any war memorials — from large monuments to small plaques or nameplates — on public property.
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Our table was in front of the display where the prizes were sitting in a row, plaques made of glass with the names of the winners engraved on them.
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That distance she maintains makes this an interesting experimental pop music — not one guaranteed to bring riches and platinum plaques, but certainly one that will push the genre forward.
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Dr Miller and his colleagues were thus able to examine the extracted plaques for the presence of gold—which they found, as by now they expected to, in abundance.
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On the ground around him, 12 feet below the tip of his battle axe, the company's eight core values are inscribed on plaques at the points of a compass.
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Among the 40 who discontinued it, most withdrew due to negative side effects, which included fluid building up in the brain as a result of the removal of plaques.
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So maybe, Condello said, those who survived longer had genetics that made their brains better at shoving the toxic prions into plaques and tangles than those who died young.
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An autopsy of the Swedish patient revealed no heart defects or genetic problems that might explain his death, and his arteries lacked the plaques that usually cause heart attacks.
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Roman cameo glass from this era, in addition to being extremely rare (only 15 other Roman cameo glass vases and plaques are known to exist), has been hugely influential.
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BAN2401 is one of a number of drugs targeting beta amyloid, a protein that forms toxic brain plaques that are theoretically an underlying cause of the memory-robbing disease.
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She lived only blocks away, right between me and my kids, in a famous old Jewish neighborhood where brass plaques denoted the hundreds of families removed by the Nazis.
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Hundreds of marble thank-you plaques on the outside wall speak of the healing power of the waters for the joints, the back and various diseases of the organs.
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Alzheimer identified two kinds of protein aggregates that are not found in younger brains: plaques that are found between brain cells and tangles that are found inside brain cells.
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"The plaques were presented to the club by a small group of members, who are incredible fans of the President, in honor of Presidents Day weekend," the spokesperson said.
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The objects she'd left behind—files, plaques, photos—were cleared out, so that her replacement, Dana Boente, who was then the acting Deputy Attorney General, could start right away.
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A magnificent set of 16th-century Benin bronze plaques were among thousands of items ripped from shrines and altars by British troops in 1897, then auctioned, and auctioned again.
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What does seem to be well established is that in people with the genetic version of the disease, there is a strong relationship between those mutations and amyloid plaques.
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For the first time in a large clinical trial, a drug was able to both reduce the plaques in the brains of patients and slow the progression of dementia.
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The piece, which is now on display in the FIFA World Football Museum in Zurich, carries only four plaques, one on each side, for the first four tournament champions.
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The engineers were taping plaques to the bottom of the spacecraft, including a memory chip containing drawings by schoolchildren who had been asked to imagine exoplanets might look like.
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In the meantime, the city's Parks Department plans to create informational plaques and commission new art for the empty stone pedestal where the Sims statue stood on Fifth Avenue.
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Mr. Blacc then makes a trip to Graceland, Mr. Presley's estate, and learns more about the musician's life and sees the almost-endless procession of plaques on the wall.
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This 2009 body of work hangs adjacent to a corollary installation of 35 wooden plaques that describe the flags of these nations and what their symbols and colors represent.
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Granato considers himself a humble caretaker of the Wisconsin connection with Olympic hockey, displayed on plaques that line the corridor outside the Badgers' locker room at the Kohl Center.
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He had tested the idea two years ago, partnering with the American watchmaker RGM to create a limited-edition Founders watch, also accented with plaques made from the sign.
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He was blown away by the 50-odd plaques on display, and more so when a security guard told him that there were 1,000 more items in the basement.
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Plaques, above a door on Via San Nicolò, mark the spot where Joyce lived and taught English in the Berlitz School, now the site of a Zara clothing store.
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Yet, beyond the festival, there are no indicators in town of the phenomena's central importance: no monuments, no plaques, no fish-shaped souvenirs on sale at shops around town.
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Dozens of photographs, trophies, plaques and medals cover the walls, cataloging his nearly 20 years in wrestling and his more recent ascension to the peak of mixed martial arts.
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For a deeper dive into musical history, here are some composers, performers and conductors whose names may be new to you, along with the addresses of their individual plaques.
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In repairing the damage, the body creates plaques of scar tissue under the skin of the penis, causing it to bend or curve abnormally or become indented when erect.
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The agreement stipulates that Macedonia must change the plaques on government institutions and reword official documents — indeed, every single one that has ever contained the words "Republic of Macedonia."
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Mount also said that it was a long and sensitive process to agree to a wording on the plaques that reflected history accurately and also met with the family's approval.
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For instance, art historian Michele H. Bogart makes a case that monuments could be amended with plaques, markers or educational tours, and be used to teach vital lessons about history.
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There's very good human genetic data developed in the past two to three years that clearly shows if you can prevent the deposition of those plaques, you can prevent Alzheimer's.
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Moreover, mice genetically engineered to produce human amyloid protein that were injected with material from these samples developed significantly more amyloid plaques than did mice injected with synthetic growth hormone.
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To put it simply, people with Alzheimer's disease have brains that are filled with rigid, clumped-together deposits of the proteins amyloid beta and tau, called plaques and tangles, respectively.
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"In other cities such as Melbourne and Perth, additional plaques have been added to historical statues to give context to the original wording or to balance history," the spokesperson said.
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Researchers say the plaques found in Alzheimer's patients' brains may be the remains of protein cages the brain used to trap microbes that managed to penetrate the blood-brain barrier.
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The plaques will return quickly to Cooperstown; they do not travel the world with their honorees the way the Stanley Cup does with members of the N.H.L.'s championship team.
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Ms. McQuinn, a champion of the jail site, recalled bumping into Mr. Wilder several years ago during a ceremony to unveil plaques honoring African-Americans who served Virginia during Reconstruction.
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In a paper published in the journal Nature in December, researchers at MIT led by Dr. Li-Huei Tsai found that light entrainment cleared plaques from the brains of mice.
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Knowing little about the Hall's vast collections, many of the nearly 300,19683 annual visitors are solely drawn to the gallery's bronze plaques that describe the achievements of all the inductees.
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He opened the bar to anyone who could find it, began to schedule candlelit jazz performances and decorated the walls with silver Heineken and Southern Comfort plaques and calligraphic tapestries.
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Scratched into their gold borders is the word "Matthews," an indication the plaques were the work of a company in Pittsburgh that made honor rolls and World War I monuments.
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" Rubino's plaque idea originated from a message he sent his friend saying, "If I die please make a plaque on a bench in Central Park that says 'he loved plaques.
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Their businesses are complementary, Harding said, with Lifetouch capturing the photos and Shutterfly helping the recipients preserve them in prints, photo albums, and gifts like calendars, coffee mugs, and plaques.
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The Huskers' practice facility — on the first floor of the student union on East Campus, about a 21-minute drive from the university's downtown nexus — heaves with trophies and plaques.
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The authorities footed one-third of the bill, while commemorative plaques, corporate sponsors and bisse membership fees filled in the rest of the 21983 million Swiss francs (or $21448 million).
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Scientists also aren't sure how, at a molecular level, strenuous exercise might prompt the buildup of plaques, and why some people's arteries remain unaffected, no matter how much they exercise.
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The Atlantic Highlands Police Department is investigating after three bronze plaques from the Monmouth County 9/11 Memorial on Mount Mitchill went missing between Wednesday and Thursday, according to police.
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A new study published this week in Alzheimer's & Dementia is now the first to find two key markers of the disease—protein plaques and tangles—in a wild animal, namely dolphins.
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The editorial, then titled "Removing statues of historical figures risks whitewashing history," originally argued that "Instead of removing painful reminders, perhaps these should be supplemented" with plaques explaining the fraught history.
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They were mostly tchotchkes, little figurines or plaques, but at the Yun Hai Elite Security training center, the school's co-founder Xin Yang gifted me a weapon disguised as a pen.
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More than half of the drugs in current late-stage trials target these β-amyloid proteins, which stick together to form plaques between nerve cells in the brain's of Alzheimer's patients.
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Sometimes people go to visit blue plaques if they're especially into the person that the plaque is there to remember, and I'd imagine that the Bowie one will be well-attended.
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Despite the many blue plaques with golden stars that dot the town to signpost EU investments, a majority of 56.4 percent voted to quit the bloc compared with 51.9 percent nationally.
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The 240-patient trial compared the effect of monthly injections with Repatha plus a cholesterol-lowering statin with statins alone on the plaques that can break off and cause heart attacks.
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The hospital has promised to keep the plaque up, but asks that if any other "magical beings" want to put up plaques, they check with the "muggles" at the hospital first.
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However, unbeknownst to him he had bought the house Miley had actually recorded her first album in, and the previous owner had left all the plaques commemorating this in the garage.
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"To me, it seems more than just a plaque of gold," said presenter Fay Bainter before welcoming McDaniel to the stage (they gave out plaques back then for the supporting categories).
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The only way to definitively diagnose Alzheimer's is still after someone has died and their brain can be examined under the microscope, looking for the telltale amyloid plaques and tau tangles.
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