859 Sentences With "non functional" | Random Sentence Generator

You'll notice that two of its systems are also non-functional.

These are about slack fill, or rather "non-functional" slack fill.

The cells that normally sense sound were disorganized, and likely non-functional.

In 1933, when FDR took power, global banking was essentially non-functional.

Looking closely at the bikes, some have what seems a non-functional decorative seat.

"I am educated, but before this I was kind of non-functional," she says.

The electricity is off, and the water, sewer, and gas systems are also non-functional.

A Russian internet disconnected from the world would probably right now be almost non-functional.

So far, the researchers have seen a dozen patients who have non-functional piezo2 receptors.

Walt Disney World has plenty of non-functional scene dressing, and that's part of the experience.

Artists who work with elements of historical dance sounds and arrive at a non-functional result.

But even if the plaintiffs are correct that the non-functional mandate is unconstitutional, so what?

However, like the stripped-down version of Moments within Facebook, Moments' web version is similarly non-functional.

If gadget makers start putting non-functional notches on phones as a pure style move, we've all lost.

There's even a non-functional slot on the back that I desperately want to cram a cartridge into.

Non-functional works: Curtis points to a long, narrow work with a form that diverges from the traditional vessel shape.

If you had the widget on your home screen, you'll now see either empty space or it'll be non-functional.

Another kitchen remodel she worked on had several issues — narrowness, poor lighting, lack of counter space, and a non-functional pantry.

The first one is a non-functional dummy unit that gives us a look at the casing design RED is shooting for.

"A limited number of Delta in-flight entertainment screens have non-functional cameras, included by the manufacturer," the spokesperson said by email.

GARRISON "I Would Wear That," study in non-functional weaving by Juliet Martin, and "FLOW," a Hudson River installation by Charles Luce.

Alex Eagleton, Carpet Carvings and Non-Functional Bongs; Curated by Safe Gallery Stay tuned for more booths to be at this weekend.

Recent visits, made possible by military escorts because the security situation remains unstable, found more than half of all medical facilities non-functional.

" Aka "basically a non-functional empty shell, acts as the placeholder for when the phone receives the 'real' Facebook app as app updates.

But today I'm sitting here sick to my stomach about the non-functional Vizio 65-inch 4K TV sitting in my living room.

The controlled blaze left charcoal-colored marks all over the wood, creating the illusion that the non-functional vehicle has actually seen combat.

"All the emergency services were non-functional, even weird nonpublic numbers buried on city [government] websites," Craig told me in a Twitter message.

The case hinges on design patents that protect non-functional or "ornamental" individual elements of a design on a wide range of products.

I can imagine the teacher and fellow students in her adult education class being bewildered by the non-functional, abstract pieces she made.

ET.Per Bloomberg, Facebook and Instagram domains ceased to be accessible by users during that time period, while Messenger and WhatsApp were also non-functional.

But one issue keeps cropping up that I think is going to become even more prevalent in the years to come: Non-functional batteries.

"When you have a bigger home, you have more to remodel or replace when it becomes out of date or non-functional," Watterson says.

THESE 'REAL' 'TRANSFORMERS' (AKA 'LETRONS', PLEASE DON'T SUE US) I respect a company that pours resources into turning luxury cars into non-functional transformers.

I was studying a totally non-functional degree — I mastered in philosophy, because I didn't know what I wanted to do with my life, honestly.

None of these approaches are inherently wrong or non-functional, but they're not novel, and not what I expect from a company like Bower & Wilkins.

Alexanya, with her non-functional mummy outfits, hideous makeup, and outrageous, incomprehensible accent, is a fairly funny one-note joke, largely relegated to the background.

HardOn/TheBelly brings together a cock ring on a plunger, a vacuum cleaner tube, and splattered make-up as something entirely decorative and non-functional.

If someone is completely down and out with cold symptoms or totally non-functional because of hay fever, that's far more interesting than a single sneeze.

Although the map itself appeared to be non-functional at the time of viewing, a dropdown menu let users select from a slew of mobile identifiers.

ATMs failed to pump out enough bills with many of them remaining non-functional, leaving people stranded of money even after wasting hours standing in queues.

You've written the email that will land you the job, get you the big meeting, or convince your landlord to finally replace your non-functional stove.

For end users, that doesn't mean the software instantly becomes non-functional, but that it will longer be updated with bug fixes or other security patches.

Lawyer speaks of 'heightened importance' A civics education is particularity important today because many perceive government "is almost non-functional on many levels," Rebell told CNN.

Xbox One owners had to deal with a pretty severe Xbox Live issue on Wednesday that made Microsoft's console almost non-functional for some of those affected.

The non-functional prototypes on display at Ikea's Democratic Design Days event in Sweden are illustrative examples of what you can expect from Ikea's new SYMFONISK range.

In this regard, Burckhardt shares something with Richard Artschwager and his non-functional faux furniture, not to mention his blurring of the boundaries between painting and sculpture.

The telecommunications system was mostly non-functional, meaning people could not communicate to identify emergency needs – and it took months to restore anywhere close to full service.

A MacRumors reader first noticed that the Google Home app now lists Apple Music as a service that can be integrated, although the ability is currently non-functional.

Almost one-third of the cash machines in India have been found non-functional, according to a survey conducted by the Reserve Bank of India, the country's central bank.

Ikea showed off some non-functional prototype speakers at its Democratic Design Days event in Sweden last year, which were also designed to be used as shelves, as seen above.

The shibboleths of the left here are really non-functional, the idea that you need to be a victim of some oppression, that you need to have economic hardship, no.

We propose that this class enables infected cells to reclaim their innate apoptotic proficiency, which renders the infective viral genome non-functional as a result of the medicine-facilitated suicide.

In his blurring of distinctions and his use of furniture, McMakin shares something with the faux, non-functional furniture of Richard Artschwager, who also made real furniture for a living.

"You should know this API isn't connected to anything in our current codebase, meaning it's non-functional and there's no existing feature using it," said the spokesperson in an emailed statement.

In addition to this sighting, another Twitter user, Tyler Kizner, found a non-functional link to Twitch Prime in his Settings section, next to "Channels & Videos," also for a brief time.

Whenever this is released, it'll be interesting to see just what this looks like (and if we'll be able to buy our own, non-functional replica for Comic-Con.)[Bleep, IBT]

The 0073 airliner made a refueling stop at Anchorage, Alaska, where the crew was informed that one of the radio navigation beacons the flight computer usually relied on was non-functional.

Every container has some amount of slack fill; the problem is non-functional slack fill, when there doesn't seem to be a purpose for that size of a void in there.

The researchers concluded that mice with a non-functional copy of CSNK1E were both more sensitive to the effects of opioids, and more sensitive to the rewarding property of the drug.

My guess is that none of them eat because they're murderous dead things that just want to make more dead things, and they don't really care about filling their non-functional bellies.

Thankfully non-functional, Nado's guns seem like strange weaponry from the future, due to their brilliantly vibrant hues and the protruding typewriter parts that seem like alien steampunk appendages in this technological recontextualization.

Three of them have been left inside the game's attached tank, where they don't have much to do except stare at the giant non-functional plastic claw that still dangles over their heads.

Groups was one of Facebook's first features, starting as a non-functional way to say you support a cause or idea, from human rights to the joy of stepping on a crunchy leaf.

"They were intended to look like IEDs, but they were totally non-functional," Henry said, referring to the improvised explosive devices common in the early years of the U.S.-led war in Iraq.

The "2018 Pod case"Photo: Yeonsoo Kang (Behance)Korean designer Yeon Kang recently published this goofy concept design she created for Caseology of a non-functional silicone case for the Apple Watch Series 4.

But right next to my working Honeycomb Glacier prototype is a far sleeker, non-functional model that represents what the device could actually look like if a manufacturer decided to make it for real.

The Uncourage is a non-functional, 3.5-millimeter jack designed for the sole purpose of ensuring your iPhone 7's Lightning to headphone dongle is always in your pocket when you reach for it.

Elon Musk revealed on a press call following the Falcon Heavy launch on Tuesday that the mannequin was wearing an actual production SpaceX crew spacesuit, rather than a non-functional prototype or mock-up.

Similarly, those with Complete Androgen Insensitivity Syndrome can be XY, but develop a normal vulva and vagina, but with no uterus and undescended, non-functional testicles because their bodies don't respond to testosterone at all.

On my prototype, the accelerometer is almost completely non-functional, and the device doesn't know when the keyboard is in tablet position — the keys remain active, and there's no prompt to activate Windows' tablet mode.

Lyft located a WAV for only 3 of 17 attempts (a 5% "success" rate), rendering the service non-functional for wheelchair users, while Uber located a WAV in only 27 of 49 different attempts (a 55% "success" rate).

To be fair, nobody at Unpacked got to try out the Galaxy Home — Samsung only had a non-functional devices on display — but even so I don't have a lot of confidence in Bixby based on past experiences.

In this case we see that they have different results for different places, concessions for some governments in spite of international concern, and the reduction of some services to a non-functional state (comparatively) in order to avoid controversy.

Kepner, 64, would like to have the non-functional hands removed, as they've made him largely immobile – much more so than his initial prosthetics, which he began using after losing his real hands to sepsis after getting strep throat in 1999.

You can buy a non-functional replica of Gandalf's film pipe from the Weta Workshop in Wellington, New Zealand, but if you're after something you can actually smoke from, there are makers on Etsy selling pipes inspired by the series.

It also found that core features — such as geofencing to set up alerts if kids stray outside a pre-set zone and SOS buttons — were flakey or non-functional, accusing the device makers of giving parents a false sense of security.

You can watch the video below from Wired for a closer look: Nike has been teasing these shoes for years now, first auctioning off a non-functional pair that were replicas of the Back to The Future props in 2011.

Though this may appear simple in design, it is actually "the result of the sophisticated analysis of proportional relationships–the precise balancing of solids and voids– and the avoidance of any non-functional, superfluous detail," according to the Landmarks Preservation Commission.

A total of 11 permanent artworks have also been installed in the museum, eight of which have been made by women, including one mind-bending and unique, non-functional staircase, constructed by Monika Sosnowska situated in the museum's main artery.

Basic Photoshop skills will allow you to simply paint over a non-functional prop lightsaber used as a reference in your photoshoot, but Stern shows us how to perfectly fake the glow that gets cast on anything near the weapon's glowing blade.

The issue they saw as needing a new approach is prosthetic arms, which as they pointed out are often either non-functional (think just a plastic arm or simple flexion-based gripper) or highly expensive (a mechanical arm might cost tens of thousands).

The grim truth is that our use of the internet is so tied to these sorts of schemes that, to be enforceable, ICO would likely force most online services to build unrecognizable and potentially non-functional versions of themselves for kids to use.

All said and done the room conversion took about two weeks to complete, including a giant non-functional NES control pad on the wall that not only frames the TV, but also cleverly allows all of the necessary cabling to be left out in the plain sight.

A strongly worded letter (PDF) from the Democrats of the House Committee on Energy and Commerce questions Equifax on pretty much every aspect of its disastrous breach, from how such an immense security lapse happened in the first place to the company's apparently non-functional notification site.

The company ran a successful drop test earlier this year, during which it let a non-functional rocket fall from the wing of the 747 launcher aircraft in a key test, and it has been signing contracts to launch from the U.K. as early as next year.

Habitat as seen through a variety of virtualized vision systems Habitat as seen through a variety of virtualized vision systems Furthermore, although Replica and many other 3D worlds like it are realistically rendered in a visual sense, they are almost completely non-functional in terms of physics and interactivity.

A number of companies are already developing the capability to build spacecraft, research equipment and advanced hardware in space using components and base materials transferred from Earth (much easier than transporting complex devices) and, potentially, mined locally from asteroids, planetary bodies or even decommissioned and non-functional older satellites.

With a non-functional Congress unable to pass legislation of nearly any type and Utah's Congressional leaders' failure to take the Tribes' proposal seriously, not incorporate the enthusiastic support of America's outdoor industry or the majority of Utah's citizens, it's time for the President to step in and use his authority under the Antiquities Act to declare a national monument protecting Bears Ears.

Non-functional pad removal Illustration how an inner layer looks with and without non-functional pads This via has the non-functional pad on layer 3 removed A non-functional pad is a pad in a printed circuit board that is not connected to a track on the layer it is on.

SNAP is the Software Non-functional Assessment Process. While Function Points measure the functional requirements by sizing the data flow through a software application, IFPUG's SNAP measures the non-functional requirements. The SNAP model consists of four categories and fourteen sub-categories to measure the non-functional requirements. Non-functional requirement are mapped to the relevant sub-categories.

Non-functional pads can be removed at any phase of the design process. Some software allows precise control during the design process, and also removes the non-functional pads during output file creation. Furthermore, some board manufacturers remove non-functional pads during data preparations. Occasionally, this process of non-functional pad removal is also called unused pad suppression.

The IFPUG method to size the non- functional aspects of a software or component is called SNAP, therefore the non-functional size is measured by SNAP Points. The SNAP model consists of four categories and fourteen sub-categories to measure the non-functional requirements. Non-functional requirement are mapped to the relevant sub- categories. Each sub-category is sized, and the size of a requirement is the sum of the sizes of its sub-categories.

His ceramics works are often asymmetrical, non-functional, and fluid looking.

The proboscis does not anneal properly post-eclosion and is non-functional.

As of the year 2020, the website is officially closed and is non-functional.

Amputation of extremities may be necessary if the disease renders the extremity non-functional.

Non- transparent 'justice systems' set up in rebel-controlled Donbas areas mostly non-functional – OSCE SMM, Interfax-Ukraine (25 December 2015) They criticized this judiciary to be "non-transparent, subject to constant change, seriously under-resourced and, in many instances, completely non-functional".

It is also a border checkpoint but presently non functional due to some unknown reasons.

Non-functional requirements are often called "quality attributes" of a system. Other terms for non-functional requirements are "qualities", "quality goals", "quality of service requirements", "constraints", "non-behavioral requirements", or "technical requirements". Informally these are sometimes called the "ilities", from attributes like stability and portability. Qualities—that is non-functional requirements—can be divided into two main categories: # Execution qualities, such as safety, security and usability, which are observable during operation (at run time).

SNAP is the acronym for “Software Non-functional Assessment Process,” a measurement of non-functional software size. The SNAP sizing method complements ISO/IEC 20926:2009, which defines a method for the sizing of functional user requirements. SNAP is a product of the International Function Point Users Group (IFPUG), and is sized using the “Software Non-functional Assessment Practices Manual,” (APM) now in version 2.4. The SNAP methodology has the IEEE standard IEEE2430-2019.

Generally, functional requirements are expressed in the form "system must do ," while non-functional requirements take the form "system shall be ." The plan for implementing functional requirements is detailed in the system design, whereas non-functional requirements are detailed in the system architecture. As defined in requirements engineering, functional requirements specify particular results of a system. This should be contrasted with non- functional requirements, which specify overall characteristics such as cost and reliability.

These sizes are then totaled to give the measure of non-functional size of the software application. Beta testing of the model shows that SNAP size has a strong correlation with the work effort required to develop the non-functional portion of the software application.

A conditional mutant with non-functional Sec14p presents with Berkeley bodies and deficiencies in protein secretion.

This may render the gene non-functional or in some cases confer some benefit to the organism.

For quite a long time, architecturally significant requirements were not recognized as an important notion. When talking about architecture, non- functional requirements or quality attributes is often used. However, recent empirical studies show that, for a software system, not all non-functional requirements affect its architecture, and requirements that are not non- functional requirements can also affect its architecture. So, architecturally significant requirements is a valuable notion that is suggested to use when talking about requirements in relation to architecture.

As yet, scientists do not fully understand how the feature of non- functional, vestigial wings arose in Nothomyrmecia macrops.

The common house-dwelling booklouse is wingless or its wings are reduced to small scale-like, non-functional wings.

Similar to function point sizing, one unit of non-functionality is the “SNAP point” and the sizing of the non-functional portion of an application can be measured by using the procedure in the APM. Similar to function points, by using the IFPUG APM, a SNAP point counting specialist can examine the software application and measure the size of its non-functional portion in units of SNAP points. Also like function points, the number of SNAP points in an application correlates with the work effort to develop the non-functional portion of that application. The original research detailing this correlation is in CrossTalk The Journal of Defense Software Engineering, as the paper “A New Software Metric to Complement Function Points The Software Non-functional Assessment Process (SNAP)”.CrossTalk The Journal of Defense Software Engineering, “A New Software Metric to Compliment Function Points The Software Non-functional Assessment Process,” Ogden ALC/TISE, Hill Air Force Base, Utah, July-August 2013.

T cell receptor gamma variable 1 (non-functional) is a protein that in humans is encoded by the TRGV1 gene.

Prototypes are either functional or non- functional. Functional "alpha" prototypes are used for testing; non-functional prototypes are used for form and fit checking. Virtual prototyping and hence for any such software solutions may also be used. This stage is where design flaws are found and corrected, and tooling, manufacturing fixtures, and packaging are developed.

The genes are diverse in sequence and function displaying various levels of expression and separate regulation controls. Some gene families also contain pseudogenes, sequences of DNA that closely resemble established gene sequences but are non-functional. Different types of pseudogenes exist. Non-processed pseudogenes are genes that acquired mutations over time becoming non- functional.

Thus functional saturated/monounsaturated PA can be degraded by hydrolysing it to form non-functional saturated/monounsaturated DAG while functional polyunsaturated DAG can be degraded by converting it into non- functional polyunsaturated PA. A lysophospholipase D called autotaxin was recently identified as having an important role in cell-proliferation through its product, lysophosphatidic acid (LPA).

The optical coronagraph that was part of the Terek experiment and designed to observe the sun was non functional from launch.

Non-functional testing includes testing performance, compatibility and fitness of the system under test, its security and usability among other things.

Sometimes, non-functional pads (or their removal) are used for copper balancing, which affects etching, bow and twist and other effects.

Proponents of surgery note that it is low-risk, and the undescended testicle is non-functional, and it can be removed with laparoscopy or a very small incision. Some stallions show improved behavior and athletic performance when the non-functional testicle is removed. Such animals are sometimes called monorchids due to having only one testicle, but usually are fertile.

He also distinguishes between functional requirements (e.g. update a record) and non-functional requirements (e.g. response time must be less than 1 second).

There is a vestigial non-functional perigynous disc and nectar is secreted by glandular trichomes distributed along the internal surface of the corolla.

Subsequently, the track remained non–functional until July 2004 when the Minister of Railways, Lalu Prasad Yadav, restarted the shuttle-train service along the line.

Have abdominal muscles and spinal extensors (upper or more commonly upper and lower). May have non-functional hip flexors (grade 1). Have no abductor function.

The company's website is non-functional and has been so since about 2008, so it is not clear if the company is still in business.

In most citrus varieties Ruby is non- functional, but in blood oranges it upregulates anthocyanin production to produce the characteristic red color of the fruit.

Dominance typically occurs when one of the two alleles is non-functional at the molecular level, that is, it is not transcribed or else does not produce a functional protein product. This can be the result of a mutation that alters the DNA sequence of the allele. An organism homozygous for the non-functional allele will generally show a distinctive phenotype, due to the absence of the protein product. For example, in humans and other organisms, the unpigmented skin of the albino phenotype results when an individual is homozygous for an allele that encodes a non-functional version of an enzyme needed to produce the skin pigment melanin.

His middle eye was non-functional and did not blink, which made "Frank and Louie appear to be staring even when his other eyes are closed".

System Testing verifies that functional and non-functional requirements have been met. Load and performance testing, stress testing, regression testing, etc., are subsets of system testing.

The role of Sam68 was further highlighted in spinal muscular atrophy (SMA), as Sam68 promotes the skipping of exon 7 leading to a non-functional SMN2 protein.

The Goldfinger DB5 cars were to have several functional spy gadgets, including smoke screen, oil slick, revolving license plates, machine guns (non-functional) and rear bullet shield.

They found this new judiciary to be "non-transparent, subject to constant change, seriously under-resourced and, in many instances, completely non- functional".Non-transparent 'justice systems' set up in rebel-controlled Donbas areas mostly non-functional - OSCE SMM, Interfax-Ukraine (25 December 2015) In July 2016 over a thousand of people, mainly small business owners, protested in Horlivka against corruption and taxes, which included charging customs fees on imported goods.

The College is very well equipped with infrastructural facilities like the academic building, library, play ground, NCC ground, canteen, hostel (non-functional), vehicle stand, sports room and auditorium.

Especially for advanced semiconductor technologies, it is expected some of the chips on each manufactured wafer contain defects that render them non-functional. The primary objective of testing is to find and separate those non-functional chips from the fully functional ones, meaning that one or more responses captured by the tester from a non-functional chip under test differ from the expected response. The percentage of chips that fail test, hence, should be closely related to the expected functional yield for that chip type. In reality, however, it is not uncommon that all chips of a new chip type arriving at the test floor for the first time fail (so called zero-yield situation).

In humans and in animals that cannot synthesize vitamin C, the enzyme -gulonolactone oxidase (GULO), that catalyses the last step in the biosynthesis, is highly mutated and non-functional.

The Youth Time International Movement () is an international non-profit non- governmental organization based in Prague, Czech Republic and its back office in Moscow (which is currently non-functional).

On the other hand, loss of function mutations need to happen in both copies of a tumor suppressor gene to render that gene completely non-functional. However, cases exist in which one mutated copy of a tumor suppressor gene can render the other, wild-type copy non-functional. This phenomenon is called the dominant negative effect and is observed in many p53 mutations. Knudson's two hit model has recently been challenged by several investigators.

As stated above all requirements must be verifiable. Non-functional requirements, which are unverifiable at the software level, must still be kept as a documentation of customer intent. However, they may be traced to process requirements that are determined to be a practical way of meeting them. For example, a non- functional requirement to be free from backdoors may be satisfied by replacing it with a process requirement to use pair programming.

In May of 2018, a confused customer defecated in the non-functional toilet seating at the southern Hong Kong location, causing the restaurant to be evacuated and closed for 2 weeks.

In this case, the null hypothesis would be that these parts of the genome are non-functional and have properties, be it on the basis of conservation or biochemical activity, that would be expected of such regions based on our general understanding of molecular evolution and biochemistry. According to these critics, until a region in question has been shown to have additional features, beyond what is expected of the null hypothesis, it should provisionally be labelled as non- functional.

In systems engineering and requirements engineering, a non-functional requirement (NFR) is a requirement that specifies criteria that can be used to judge the operation of a system, rather than specific behaviors. They are contrasted with functional requirements that define specific behavior or functions. The plan for implementing functional requirements is detailed in the system design. The plan for implementing non-functional requirements is detailed in the system architecture, because they are usually architecturally significant requirements.

The Supreme Judicial Council Tuesday adjourned hearing of presidential reference against non-functional chief justice Iftikhar Muhammad Chaudhry till 13 April. Barrister Aitzaz Ahsan, leading lawyer assisting the non-functional Chief Justice in the reference, gave his arguments for open trial in the SJC proceedings, which were continued for an hour. He argued against in-camera hearing of the reference. Barrister Wasim Sajjad and former minister of law Khalid Ranjha appeared before the SJC on behalf of the government.

Seven of these are nonsense and 10 of these are missense. One form of the nonsense mutations deletes exon 2, leading to 4 different potential protein products that all lack an N-terminus. Another nonsense mutation deletes exon 6, which eradicates the guanine recognition site, making Sar1B non-functional. The 5 other nonsense mutations produce proteins that do not have a C-terminus, also resulting in a non-functional recognition site for a guanine base in Sar1B.

Polysplenia sometimes occurs alone, but it is often accompanied by other developmental abnormalities such as intestinal malrotation or biliary atresia, or cardiac abnormalities, such as dextrocardia. These accessory spleens are non-functional.

Some individuals have also an accessory duct, named accessory pancreatic duct, which may be functional (that is, it also empties the contents of the exocine pancreas into the duodenum) or non-functional.

The buttons and buttonholes at the end of suit jacket sleeves are generally decorative and non-functional. "Surgeon’s cuffs" can be opened at the wrist, and are traditionally associated with bespoke tailoring.

With fixed inputs, every execution is guaranteed to give the same result. Even non-functional programs become deterministic in this restricted environment. This makes programs easier to debug since their behavior is fixed.

On April 29, 2010 it was announced that Rosato would return to Eyewitness News This Morning that day after being on leave for 3 weeks following surgery to remove a non-functional kidney.

When the bombs do come and fire engulfs the city, her foresight actually saves her, but at what cost? She is the sole beneficiary of her misfortune in an otherwise non-functional existence.

A Bell Canada "dry loop" DSL connection does supply battery, but the underlying phone line is non-functional except to call 958-ANAC, 9-1-1 or the 310-BELL telco business office.

If the heterozygote and the functional-allele homozygote have identical phenotypes, the functional allele is dominant to the non-functional allele. This occurs at the albino gene locus: the heterozygote produces sufficient enzyme to convert the pigment precursor to melanin, and the individual has standard pigmentation. # Less commonly, the presence of a single functional allele gives a phenotype that is not normal but less severe than that of the non-functional homozygote. This occurs when the functional allele is not haplo-sufficient.

The ribonuclease activity of ECP is not essential for cytotoxicity. When the two known ribonuclease active-site residues are modified to non-functional counterparts (Lysine at position 38 to Arginine and Histidine at position 128 to Aspartate) and compared to the wild-type ECP, the mutated ECP retains its cytotoxicity but no longer has its ribonuclease activity. The experiment confirmed that converting the two amino acids to non-functional counterparts did inhibit ECP’s ribonuclease activity. However, ECP retained its anti-parasitic activity.

The SNAP sizing process is very similar to the function point sizing process. Within the application boundary, non-functional requirements are associated with relevant categories and their sub-categories. Using a standardized set of basic criteria, each of the sub- categories is then sized according to its type and complexity; the size of such a requirement is the sum of the sizes of its sub-categories. These sizes are then totaled to give the measure of non-functional size of the software application.

After the Sixth Central Pay Commission, the government implemented "Non Functional" ranks. Avay Shukla, who retired in 2010, said, "Whenever any Indian Administrative Service officer ... in pay band 3 or pay band 4, is promoted, members of the Indian Police service and other All India Services (AIS), senior to such officers will be automatically be eligible to be appointed to the same grade on non-functional basis from the date of posting of the Indian Administrative Service officer in that particular grade".

The cellular disadvantage in the rearrangement process is that many of the combinations of the T cell receptor gene fragments are non-functional. To eliminate thymocytes which have made a non-functional T cell receptor, only cells that have successfully rearranged the beta chain to produce a functional pre-TCR are allowed to develop beyond the DN3 stage. Cells that fail to produce a functional pre-TCR are eliminated by apoptosis. This process is referred to as the beta-selection checkpoint.

Luanda is the starting point of the Luanda railway that goes due east to Malanje. The civil war left the railway non- functional, but the railway has been restored up to Dondo and Malanje.

Boa constrictors also have two lungs, a smaller (non-functional) left and an enlarged (functional) right lung to better fit their elongated shape, unlike many colubrid snakes, which have completely lost the left lung.

Non-functional exterior shutters can be constructed from wood, vinyl, fiberglass or other synthetic materials. Non- functional shutters can be simply screwed or bolted directly to the building, with spacers or other hardware to prevent water accumulating against the wall. Fiberglass, a material widely used for boat hulls, is not prone to rotting or twisting, is dimensionally stable and has low expansion and contraction. It is a reinforced plastic, unlike vinyl or PVC, so fiberglass shutters do not have a tendency to warp or sag.

Gene conversion is of two types - interallelic and interlocus gene conversions. The resurrection of seminal RNase gene function is believed to be the unexpected consequence of the interlocus gene conversion event of seminal RNase pseudogene with its homologous functional gene. In these recombination events, the genetic information is transferred from a donor functional locus to that of an acceptor pseudogene which is non- functional. Thus the non-functional seminal RNase pseudogene has acquired some new physiological functions being in the state of dead for many million years.

Architectural decisions influence and impact the non-functional characteristics of a system. Each architectural decision describes a concrete, architecturally significant design issue (a.k.a. design problem, decision required) for which several potential solutions (a.k.a. options, alternatives) exist.

With the same number of emulated Sys Z processors, z/PDT is about 3 times faster than Hercules. Note that there are other non-functional system attributes beyond performance which are typically relevant to mainframe operators.

Broughton Mills is a village in Cumbria located 3.5 kilometres from the larger town of Broughton-in-furness. The village consists of about 40 households, a phonebox (non-functional), church and a pub called the Blacksmiths Arms.

While very few mutations in CNGB3 have been characterized, the vast majority of them result in truncated channels that are presumably non-functional. This will largely result in haploinsufficiency, though in some cases the truncated proteins may be able to coassemble with wild-type channels in a dominant negative fashion. The most prevalent ACHM3 mutation, T383IfsX12, results in a non-functional truncated protein that does not properly traffic to the cell membrane. The three missense mutations that have received further study show a number of aberrant properties, with one underlying theme.

Alternately, internally single terminated couplers (with or without the non-functional bus connectors) can be supplied. Even if only one non-terminated coupler acts as the bus because all devices (bus controller, remote terminals, etc.) are connected to the couplers stubs, the external bus connections of the coupler must be terminated. A dual- terminated coupler (with or without non-functional bus connectors) can be employed where the coupler acts as the bus without other couplers. RFI dust caps (with or without safety chains) are recommended for all unused stub ports.

Help Methods (subcategory 2.2) are usually considered non- functional. When compared to the function point process, which requires data to cross an application’s boundary and maintain an internal logical file, the Help data may be coded to reside internally as part of the application development and be accessed upon command from the user. This access can be anything from bubble help over an icon on a screen, to access of part of an internally stored application operations manual. Data is not being processed per se, so Help is usually considered non-functional.

It is often due to a metabolic disease in which a protein involved in the breakdown of lysine is non functional due to a genetic mutation. It may also occur due to a failure of renal tubular transport.

The Thall-Parachinar road is the main road connecting Parachinar to the rest of the country. Parachinar has an airport but currently it is non functional. In the past there was a flight service between Peshawar and Parachinar.

It was not until the 1930s that the mill was cosmetically restored by British Mandate authorities together with the Pro-Jerusalem Society. During this restoration decorative, non-functional fixed sails were placed at the top of the structure.

The known mutations in this gene, all result in truncated proteins. Presumably, then, these proteins are non- functional and, consequently, cone opsin that has been activated by light does not lead to altered cGMP levels or photoreceptor membrane hyperpolarization.

Exonucleases may also cause shortening of this junction, however this process is still poorly understood. Junctional diversity is liable to cause frame-shift mutations and thus production of non-functional proteins. Therefore, there is considerable waste involved in this process.

It can cause frequent blockage of the ureter leading to serious kidney damage. In other cases, a small, upper portion of the kidney is congenitally non-functional. Though often benign, this problem can necessitate the removal of non-functioning parts.

June Schwarcz (née June Morris, June 10, 1918 in Denver – August 2, 2015) was an American enamel artist who created tactile, expressive objects by applying technical mastery of her medium to vessel forms and plaques, which she considers non-functional sculpture.

Within systems engineering, quality attributes are realized non-functional requirements used to evaluate the performance of a system. These are sometimes named "ilities" after the suffix many of the words share. They are usually Architecturally Significant Requirements that require architects' attention.

Aspect-orientation is not limited to programming since it is useful to identify, analyse, trace and modularise concerns (e.g., PREview) through requirements elicitation, specification and design. Aspects can be multi-dimensional by allowing both functional and non- functional behaviour to crosscut any other concerns, instead of just mapping non-functional concerns to functional requirements. One view of aspect- oriented software development is that every major feature of the program, core concern (business logic), or cross-cutting concern (additional features), is an aspect, and by weaving them together (a process also called composition), one finally produces a whole out of the separate aspects.

The cannons are lightweight and non-functional to save weight. Manilla rope has been used for the majority of the rigging and the sails made of linen canvas. An engine will be used for safety, and electric generators for lighting and basic amenities.

Another unusual feature of male visored bats is the presence of a large fold of skin on the neck, which can be pulled up over the face as a mask while sleeping; the fold is much smaller and apparently non-functional in females.

PomA is a protein that is part of the stator in Na+ driven bacterial flagella. It has a high degree of homology to MotA, and Rhodobacter sphaeroides MotA can functionally complement a non-motile Vibrio alginolyticus with a non- functional pomA gene.

Typically, the nose is either missing or non-functional. This deformity (called proboscis) usually forms above the center eye or on the back, and is characteristic of a form of cyclopia called rhinencephaly or rhinocephaly.Dark, Graham (2007). Rhinocephaly. In Online Medical Dictionary.

The eye structure is very different from other octopods. Their eyes are small, lens-less and almost non-functional, as the eyes also lack irises and ciliary bodies. The nearly sightless eyes are embedded deep in the gelatinous tissue of their head.

BTM additionally has the ability to include the discovery and profiling of transaction issues centered at the simulated user-level. This is achieved through automation and AI techniques that also perform functional and non-functional testing - at both the systematic and micro levels.

The ratio of these remaining cells is dictated by an individual's hormone status. Peg cells are thought to represent a quiescent maturational stage of the background non-ciliated secretory cells. Unlike secretory cells, these cells lack apical granules reflecting their non- functional nature.

The airport remained non-functional after the clashes. Government spokesman Nasser al-Manee said that "the airport will resume operation within 24 hours. [He] heard there were some injured". The next day, on 6 June, some airliners restarted their flights from Tripoli International.

Phthisis bulbi is a shrunken, non-functional eye. It may result from severe eye disease, inflammation or injury, or it may represent a complication of eye surgery. Treatment options include insertion of a prosthesis, which may be preceded by enucleation of the eye.

Denix (a Spanish Company) is famous in making many replicas of historical weapons including flintlock and caplock dummy pistols for decoration purpose. It also makes a few modern models of dummy non-functional full metal replicas which are generally ignored by most modelgun collectors.

The important posts/ grades in Survey of India are in the following order of seniority: Draftsman, Plane Tabler, Survey Assistant, Surveyor, Officer Surveyor, Deputy Superintending Surveyor, Superintending Surveyor, Superintending Surveyor (Non-Functional Second Grade)/Deputy Director, Director/Deputy Surveyor General, Additional Surveyor General, Surveyor General.

Ann Verdcourt was the winner of the 'Non-functional' award for her work Thoughts of Vegetation in the New Zealand Society of Potters exhibition at the Royal Easter Show in 1995. In 2003, her work Play won a Merit Award in the Portage Ceramic Awards.

During the summers and monsoon season of Bangladesh, rivers at Fulgazi overflow causing damages to the flood embankment and rice crops by flooding and making access to Fulgazi difficult by road, resulting in famine. A non functional rail track runs through this sub-district.

Directly across the street to the north is another, larger, ablutions house (dar al-wuḍūʾ) with latrines. Right next to this is the Dar al-Magana or "House of the Clock", which features a famous but currently non- functional hydraulic clock on its facade.

But since it is not transcribed, it may disappear without affecting fitness, unless it has provided some beneficial function as non-coding DNA. Non-functional pseudogenes may be passed on to later species, thereby labeling the later species as descended from the earlier species.

Queensland Government Gazette. 75. 8 March 1901. pp. 967-980. At that time the county was carved out of Palmer County. Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles.

Queensland Government Gazette. 75. 8 March 1901. pp. 967-980. a large portion was carved off to create Burrandilla County, Queensland . Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles.

Much studio pottery is tableware or cookware but an increasing number of studio potters produce non-functional or sculptural items. Some studio potters now prefer to call themselves ceramic artists, ceramists or simply artists. Studio pottery is represented by potters all over the world.

The beta cells of the pancreatic islets secrete insulin, and so play a significant role in diabetes. It is thought that they are destroyed by immune assaults. However, there are also indications that beta cells have not been destroyed but have only become non-functional.

The cause was eventually traced to gas bubbles in the unit, which remained non-functional until a Progress resupply mission in October 2004. In 2005 ISS personnel tapped into the oxygen supply of the recently arrived Progress resupply ship, when the Elektron unit failed.

Lordosis behavior is non- functional in humans, although lordosis-like positions can be observed in women being mounted from behind.Pfaus, J. G.; Flanagan-Cato, L. M.; Blaustein, J. D. "Female sexual behavior". in Plant T., Zeleznik A. (Eds). Knobil and Neill's Physiology of Reproduction.

Troglobitic insects commonly have no functional wings, and many have no wings at all. Among the cave beetles the elytra may be retained as sclerotised bodily protection, but the hind wings, that are used for flight in most beetles, are non-functional or absent.

Bell, dozens of states added new sterilization statutes, or updated their constitutionally non-functional ones already enacted, with statutes which more closely mirrored the Virginia statute upheld by the Court. Quinn, Peter (February/March 2003). "Race Cleansing in America " American Heritage. Retrieved 7-27-2010.

The PAX2 gene is also thought to play a role in MCDK. The contralateral kidney often undergoes hypertrophy. This is believed to be a compensatory mechanism to the non-functional MCDK. About 90% of patients with an MCDK will have contralateral hypertrophy into adulthood.

Testing will determine the breaking point, the point at which extremes of scalability or performance leads to unstable execution. Non-functional requirements tend to be those that reflect the quality of the product, particularly in the context of the suitability perspective of its users.

Old pipes were reconstructed and new ones were built. Bellows expansion joints were established and the non-functional local resistances were eliminated. At present, the total length of pipelines of steam-water mixture is more than 10 km. The longest well depth is 2.3 km.

Gurbir Singh Sandhu as President and Col. K. S. Cheema as Secretary.S. Dilbag Singh Sandhu of Shri Hargobindpur have contributed towards the development of this college. The College runs its own non-functional multi-specialty 100 bedded Hospital with Medicine and Surgery as main Departments.

Normally a goal is a very strict and clear logical criterion. It is satisfied when all sub-goals are satisfied. But in non-functional requirements you often need more loosely defined criteria, like satisficeable or unsatisficeable. The term satisficing was first coined by Herbert Simon.

This reductionist approach lies somewhat in contrast to a systems thinking approach as represented by Peter Checkland's soft systems methodology. In addition to functional requirements captured in a use case description, an analyst may include such non-functional requirements as response time, learnability, etc.

Remember also that non- functional testing (security, performance, usability) plays an important role in proving business continuation. In some companies, whenever there is a fix in one unit, all unit test cases for that unit will be repeated, to achieve a higher level of quality.

In Ilex aquifolium (see the illustration), the common European holly, both kinds of flower have four sepals and four white petals; male flowers have four stamens, female flowers usually have four non- functional reduced stamens and a four-celled ovary. Since only female plants are able to set fruit and produce berries, this has consequences for gardeners. Amborella represents the first known group of flowering plants to separate from their common ancestor. It too is dioecious; at any one time, each plant produces either flowers with functional stamens but no carpels, or flowers with a few non-functional stamens and a number of fully functional carpels.

The basic idea is to search existing code for places where speculation touches upon otherwise inaccessible data, manipulate the processor into a state where speculative execution has to touch that data, and then time the side effect of the processor being faster, if its by-now-prepared prefetch machinery indeed did load a cache line. # Finally, the paper concludes by generalizing the attack to any non-functional state of the victim process. It briefly discusses even such highly non-obvious non-functional effects as bus arbitration latency. The basic difference between Spectre and Meltdown is that Spectre can be used to manipulate a process into revealing its own data.

Function points and SNAP points measure two different aspects of software, and therefore are not added together. For example, an application of 500 function points and 300 SNAP points cannot be considered to be the size 800 of some metric; function points and SNAP points are intended to be orthogonal. A good reference for further detailed information regarding the relationship between functionality and non- functionality is in the document “Glossary of Terms for Non-Functional Requirements and Project Requirements Used in Software Project Performance Measurement, Benchmarking and Estimating”.COSMIC, IFPUG, “Glossary of Terms for Non-Functional Requirements and Project Requirements Used in Software Project Performance Measurement, Benchmarking and Estimating,” v.

Flies who emerged from underground were on average larger, heavier, and less likely to have non-functional or malformed wings than flies who emerged at ground level. P. tibialis larvae have different likelihoods of inducing self- burial behavior depending on the species of the Hymenopteran host.

Documentation testing is part of non-functional testing of a product. It may be a type of black box testing that ensures that documentation about how to use the system matches with what the system does, providing proof that system changes and improvement have been documented.

Axel van Lamsweerde (born 1947) is a Belgian computer scientist and Professor of Computing Science at the Universite catholique de Louvain, known for his work on requirements engineering and the development of the KAOS goal-oriented modeling language.Chung, Lawrence, et al. "Non-functional requirements." Software Engineering (2000).

Mouthparts are non-functional, as adults do not feed.A teacher’s introduction and reference toMayflyEphemeroptera-galactica Typical curved body posture of E. danica, in the rest positionThese insects are part of the aerial plankton and usually they are food for swallows, trouts and many amphibians and spiders.

In 1969 the Creusot hammer was dismantled and reassembled in Le Creusot town square. Although it has no source of steam in its current location and is therefore non-functional, it still serves as a tourist attraction and a reminder of a bygone era of technological achievement.

Visual field defects may be one of the first signs of non-functional pituitary tumor. These are much less frequent than functional adenomas. Systemic hormonal aberrations such as Cushing’s syndrome, galactorrhea and acromegaly usually predate the compressive signs. Pituitary tumors often encroach upon the middle chiasm from below.

Paddles from Tybrind Vig show traces of highly developed and artistic woodcarving. This is an example of the embellishment of functional pieces. The population also polished and engraved non-functional or not obviously functional pieces of bone or antler. Motifs were predominantly geometric with some anthropomorphic or zoomorphic forms.

This reduces diaphragm or reed excursion, reducing harmonic and intermodulation distortion. ; Polarity: Polarity matters when dc is present in the speaker. Wrong polarity weakens the magnetic field, and can sometimes demagnetise the permanent magnet, leaving the speaker non-functional. When powered with ac only, polarity is a non- issue.

To tackle pollution in the lake, sewage treatment plants were set up by the local pollution control board in 2006. As years passed by, the plant became non-functional. Durgam Cheruvu in 2013 is now a place to relax. There is an amphitheatre, and the On the Rocks cafeteria.

He reported that the hospital was in a dilapidated condition, under- staffed and most hospital equipments were non-functional. This institute has two psychiatrists nowadays and two medical officers. Administration is supervised by chief medical superintendent. Both psychiatrists are having experience of over ten years in their field.

However, some modern applications are written to be almost entirely agnostic to the database technology, so a change from Sybase, MySQL, DB2 or SQL Server to Oracle should only require a testing cycle to be confident that both functional and non- functional performance has not been adversely affected.

The SNAP beta test in 2012 was conducted using 48 applications. More research will hopefully improve the calibration of the subcategory weighting factors to yield an even stronger statistical correlation. It is recommended that future research results be submitted to IFPUG’s Non-functional Sizing Standards Committee (NFSSC) for review.

1–134 and 134–382), suggesting a binary form (especially with the repeat of the entire section A) but the form is created cumulatively from a succession of fifteen thematically based smaller sections (four in the first part and eleven in the second) in a non-functional harmonic context .

Götlind, Anna (1993). Technology and Religion in Medieval Sweden p.142 Several written records mention the clock in the following centuries: it is, for example, compared with the Strasbourg astronomical clock in the Encyclopédie in 1779. It appears to have been non-functional already by the 17th century, however.

The FNUnivSA created a website www.FNUniverse.com (2007) and newsletter (2006) in response to lack of communication on campus. As of 2016, the website is now non- functional, and the status of the newsletter is unknown. The organization will soon be incorporated under the Non-profit Corporations Act, 1995.

Bright pink to purplish solitary flowers appear in the leaf axils, open during the day but close up at night and remain closed on cloudy days. These colored whorls are not petals, but non-functional modified stamens. Normal stamens are yellow. Flowers bloom primarily from spring to fall.

Broadly, functional requirements define what a system is supposed to do and non-functional requirements define how a system is supposed to be. Functional requirements are usually in the form of "system shall do ", an individual action or part of the system, perhaps explicitly in the sense of a mathematical function, a black box description input, output, process and control functional model or IPO Model. In contrast, non-functional requirements are in the form of "system shall be ", an overall property of the system as a whole or of a particular aspect and not a specific function. The system's overall properties commonly mark the difference between whether the development project has succeeded or failed.

These are often decorated with the name of the company that the water tower serves. Sapp Bros. truck stops use a water tower with a handle and spout – looking like a coffee pot – as the company logo. Many of their facilities have decorated actual water towers (presumably non-functional) on-site.

Alternately, trans-splicing of two non- functional RNA molecules may produce a single, functional RNA. Similarly, at the protein level, proteins that function as dimers may form a heterodimer composed of one protein from each alternate gene and may display different properties to the homodimer of one or both variants.

418+382G>C, g.7044G>C, and IVS5+382 G>C as well as a c.149G>A missense mutation in exon 3. The intronic mutations have been suggested to activate a cryptic splice site, resulting in the production of a splice variant that encodes a putatively non-functional protein.

The only other buildings on the site are two outhouses, located to the rear of the school building. Both are non-functional, display models. One outhouse is an original 1870s structure, transported to the site and reassembled. The other outhouse is a copy, built from salvaged materials during the school restoration.

Game must also support FFB. There is a bug in the Windows 8 joystick control panel which causes the joystick to be reported as non-functional. Games will still recognize and use the joystick. A user-made adapter exists for modern Windows versions (XP and later), Mac OS X and Linux.

These fishes have just one of at least two distinct sexes in any one individual organism (Gonochorism). They are oviparous and non-functional hermaphrodite. They mainly feed on copepods, other small planktonic crustaceans and algae. Adults form a permanent harem, with one male and several females close to coral heads.

This binding initiates a signal transduction pathway, which results in the modulation of IFN-γ. A deletion in the SH2D1A gene leads to a non-functional SH2 domain on the SAP protein, making it unable to bind to SLAM. This leads to aberrant IFN-γ modulation, causing uncontrolled cell proliferation.

Female mammals are therefore called genetic mosaics, for having two different X chromosomes expressed throughout their body. Tsix binds complementary Xist RNA and renders it non-functional. After binding it, Xist is made inactive through dicer. Thus, Xist does not condense chromatin on the other X chromosome, letting it remain active.

A layout of previous partitions is visible on the ceiling. There are four non- functional fireplaces without mantle or firebox. A rear room contains a kitchen. Timber-framed, glazed French doors and a clear-finished panelled timber door open onto the rear verandah from the rear rooms of the first floor.

Component Based Software 4.2.Multiple Input / Output interfaces For example, software development to change the field sizes for data in a data table does not represent changes in data processing capacity. However, this development requires work effort. Data Formatting is considered non-functional, and is countable under SNAP subcategory 1.3.

Therefore, ERG may act as a regulator of differentiation of early hematopoietic cells. The Mld2 mutation, generated through an ENU mutagenesis screen, was the first non-functional allele of Erg. Homozygous Mld2 is embryonic lethal at day 13.5. Adult mice heterozygous for the Mld2 mutation have hematopoietic stem cell defects.

Ocnogyna is a genus of moths in the family Erebidae from western Eurasia. The genus was erected by Julius Lederer in 1853. One aberrant species, Ocnogyna parasita, has females with non-functional wings, and because of this was formerly placed in its own genus Somatrichia, but is now in Ocnogyna.

Visually, though, the new Modernist stage clashed with the elegant Art Deco design of the concert hall. In addition, the organ's pipe chambers were effectively sealed off from the auditorium by the new shell — rendering the organ non-functional unless its sound was transmitted into the auditorium through microphones and speakers.

In March 1951 the party joined the Consultative Body of Political Parties, a broad coalition initiated by PKI that soon became non-functional. During the following year, PKI-Murba relations improved significantly. At the time, Murba guerrilla units still roamed in West Java and held some territories under their control.Feith, Herbert.

He moved on to work for the Allison Engine Company in California. Clessie Cummins continued to innovate until his death. He identified the problem of vehicle brakes overheating and becoming non-functional during long, steep downhill descents. As a result, he designed and patented the first compression release engine brake.

NFR (Non-Functional Requirements) need a framework for compaction. The analysis begins with softgoals that represent NFR which stakeholders agree upon. Softgoals are goals that are hard to express, but tend to be global qualities of a software system. These could be usability, performance, security and flexibility in a given system.

Most vestigial limbs are non- functional, and although they may have bones, muscles and nerve endings, they are not under the control of the host. The possession of six or more digits on the hands and feet (polydactyly) usually has a genetic or chromosomal cause, and is not a case of vestigial twinning.

Curra is in the Wide Bay–Burnett region of Queensland. It was once part of Shire of Tiaro but is now within the Gympie Region local government area. It also belongs to the non-functional administrative unit known as the County of March. It is situated on the Bruce Highway, north of Gympie.

Anita Fields (born 1951) is an Osage/Muscogee Creek Native American artist from the U.S. state of Oklahoma. Fields is nationally recognized for her unique rendering of ceramic sculptures and mixed-media installations. As a Native American ceramic artist, she has created conceptual installations. Fields specializes in ceramics, non-functional earthenware, and ribbonwork.

The service concept represents a unit of essential functionality that a system exposes to its environment. For the external users, only this external functionality, together with non-functional aspects such as the quality of service, costs etc., are relevant. Services are accessible through interfaces, which constitute the external view on the structural aspect.

A mutation in the caspase gene can either cause the protein to be non-functional thereby allowing the cells to live and accumulate in the tissue or cause a DNA damaged protein to live and disrupt the body for further harm. This occurs commonly in the brain, leading to neurodevelopmental or neurodegenerative diseases.

L-gulonolactone oxidase (EC 1.1.3.8) is an enzyme that produces vitamin C, but is non-functional in Haplorrhini (including humans), in some bats, and in guinea pigs. It catalyzes the reaction of L-gulono-1,4-lactone with oxygen to L-xylo-hex-3-gulonolactone and hydrogen peroxide. It uses FAD as a cofactor.

In normal physiology, lymphocytes that recognise human proteins (autoantigens) either undergo programmed cell death (apoptosis) or become non-functional. This self-tolerance means that lymphocytes should not incite an immune response against human cellular antigens. Sometimes, however, this process malfunctions and antibodies are produced against human antigens, which may lead to autoimmune disease.

An interior courtyard illuminates interior spaces. Deep fixed overhangs on the south shade the windows from the sun, and are matched by non-functional overhangs on the north side. The east and west elevations feature bright blue adjustable aluminum louvers for sun control. The louvers are motorized to provide daylighting without direct glare.

YouTube (accessed 6-20-08) Level progression can be pieced together by the selectable stages, with two or three levels per world. Each level has an exit such as a Warp Pipe, a Trojan Horse, or a stylized "M" object holding tapesome of which are non-functional, so the system must be restarted.

From 2008 onwards, the utility provided water points to the slums without requiring a guarantee. A pilot project for a small-bore sewer system in the Mirpur area of Dhaka was implemented several years ago, with financing from the Asian Development Bank. This scheme was never commissioned and is now completely non-functional.

However, telephones, air conditioning, and four of the tower's five elevators were left non-functional because of the main power failure. Carbon monoxide, freon and methane, all originating from the auxiliary generator, infiltrated the tower through ventilation ducts, forcing an evacuation of the building. Between 9:00 a.m. and 11:00 a.m.

For example, a mutation that results in a non-functional protein on both alleles was always found with the severe ACG- IB phenotype, but non-functional mutations on both alleles were never found with the less severe phenotypes, DTD and rMED. Mutations found in the moderately severe AO-II phenotype were always the result of a non-functioning mutation on one allele and a partial-functioning mutation on the opposite allele. In contrast, mutations described in the mildest form of the chondrodysplasia, rMED, result in proteins that retain at least some partial sulfate transport function on both alleles. This suggests that even a small amount of SLC26A2-mediated sulfate transport in chondrocytes can mitigate the clinical severity of the chondrodysplasia.

Organization of the eukaryotic nuclear ribosomal DNA tandem repeats. External transcribed spacer (ETS) refers to a piece of non-functional RNA, closely related to the internal transcribed spacer, which is situated outside structural ribosomal RNAs (rRNA) on a common precursor transcript. ETS sequences characteristic to an organism can be used to trace its phylogeny.

A variety of hand loom and handicraft products are produced. Agriculture is the main source of income for the majority of the population. The Central Rice Research Institute is located at Khangabok. The Khansari sugar factory was established in Khangabok, but it is non-functional at present and has been converted into an IRB battalion.

Only one paralog, a pseudogene, for FAM185A exists in humans. The pseudogene, known as FAM185BP (Family of sequence similarity 185, member B, pseudogene), is also located on chromosome 7, from 76,713,203bp to 76,751,689bp. The pseudogene encodes a non-functional 365aa protein, of which the first 356 residues are identical to that of FAM185A isoform 1.

A functional characteristic is known in evolutionary biology as an adaptation, and the research strategy for investigating whether a character is adaptive is known as adaptationism. Although assuming that a character is functional may be helpful in research, some characteristics of organisms are non-functional, formed as accidental spandrels, side effects of neighbouring functional systems.

The Sociolology of Literature, trans. E. Pick, London: Cass, p. 18. His focus fell on the "community of writers", understood in aggregate as "generations" and "teams". He extended the definition of literature to include all "non-functional" writing and also insisted that literary success resulted from "a convergence of intentions between author and reader".

An Introduction to Functional Grammar. Arnold: p. 6. This entry is mainly about sentence in its non-functional sense, though much work in functional linguistics is indirectly cited or considered such as the categories of speech act theory. A sentence can include words grouped meaningfully to express a statement, question, exclamation, request, command or suggestion.

The village has a public library a swimming pool (non-functional) and a football pitch. The most important people born in Gemerska Poloma are Peter Kellner-Hostinský and Peter Madáč. Peter Kellner-Hostinský (1823-1873) was an important writer, philosopher, historitian, economist. Peter Madac was a famous doctor of medicine and a specialist in physics.

The hospital was built during the late 1960s and was commissioned by Idi Amin in 1972. The hospital infrastructure is dilapidated and the equipment is antiquated or non-functional. The hospital is severely under-staffed, employing only 60 nurses out of the 120 needed. As of January 2016, the facility had no functioning ambulance.

Chaniotis B. N., Butler J. M., Ferguson F. F. & Jobin W. R. (1980). "Presence of males in Puerto Rican Thiara (Tarebia) granifera (Gastropoda: Thiaridae), a snail thought to be parthenogenetic". Caribbean Journal of Science 16: 95–97. PDF. Live sperm were present in the testes of these males but the genitalia were apparently non-functional.

Other non-functional requirements will trace to other system components and be verified at that level. For example, system reliability is often verified by analysis at the system level. Avionics software with its complicated safety requirements must follow the DO-178B development process. Activities that lead to the derivation of the system or software requirements.

In the past, echolalia was regarded as negative, non-functional behavior. However, researchers such as Barry Prizant and colleagues have emphasized the communicative function of echolalia. Among the communicative functions noted are turntaking, requesting, self-regulation and rehearsal to aid comprehension. Echolalia can be categorized as communicative (in context and with "apparent communicative purpose") vs.

Sant'Andrea is an extremely dynamic building both without and within. Its triumphal façade is marked by extreme contrasts. The projection of the order of pilasters that define the architectural elements, but are essentially non- functional, is very shallow. This contrasts with the gaping deeply recessed arch which makes a huge portico before the main door.

While some mutations in CNGA3 result in truncated and, presumably, non-functional channels this is largely not the case. While few mutations have received in-depth study, at least one mutation does result in functional channels. Curiously, this mutation, T369S, produces profound alterations when expressed without CNGB3. One such alteration is decreased affinity for Cyclic guanosine monophosphate.

Shortly after the entrance of the park, the bust of the famous general can be seen, watching over the city. The park contains memorials with the names of the Russian and Romanian soldiers that died for the liberation of Pleven, and is decorated with non- functional arms donated by Russia: cannons, cannonballs, gatling guns, rifles, and bayonets.

Software architecture analysis method (SAAM) is a method used in software architecture to evaluate a system architecture. It was the first documented software architecture analysis method, and was developed in the mid 1990s to analyze a system for modifiability, but it is useful for testing any non- functional aspect. SAAM was a precursor to the architecture tradeoff analysis method.

This opening leads to a small glandular sac lined with white hairs, which produces a waxy substance of unknown function. Males possess scent gland on the perineum, producing a clear fluid with a musky smell. Females have two true nipples on the chest, and an additional, non- functional, pair on the abdomen, providing additional support for the young.

These severe phenotypes are consistent with a lack of Cdc42 activity, as it controls membrane traffic as well as the organization of the actin cytoskeleton. Mutations in the FGD1 gene that cause the production of non-functional proteins are responsible for the severe phenotype of the X-linked disorder faciogenital dysplasia (FGDY), also called Aarskog-Scott syndrome.

Three trims levels were offered, SR5, Sport Edition, and Limited. When it was first introduced the SR5 and Sport Edition models used gray plastic cladding and bumpers. Sport models also featured a non-functional hood scoop. Toyota Hilux Surf SSR-X The front suspension used a double wishbone while the rear is a solid rear axle type.

Nesiritide, a recombinant form of B-natriuretic peptide, is indicated for use in patients with acute decompensated heart failure who have dyspnea at rest. Nesiritide promotes diuresis and natriuresis, thereby ameliorating volume overload. It is thought that, while BNP is elevated in heart failure, the peptide that is produced is actually dysfunctional or non-functional and thereby ineffective.

This results in a truncated non- functional protein. Nav1.7 channels are expressed at high levels in nociceptive neurons of the dorsal root ganglia. As these channels are likely involved in the formation and propagation of action potentials in such neurons, it is expected that a loss of function mutation in SCN9A leads to abolished nociceptive pain propagation.

Other changes included four piston front brake calipers, a shorter (3.25:1) differential ratio, the driveshaft from the M5, a twin-plate clutch, a non-functional rear seat, no air conditioner, a deeper front splitter and a larger rear spoiler. The cars were individually numbered with a plaque fitted to the centre console near the handbrake.

La Vale Tollgate House is a historic toll house in La Vale, Allegany County, Maryland, United States. It is a two-story brick structure built in 1835–1836, with seven sides—a basic polygon plan. A one-story Tuscan-columned porch extends around the five outer sides of the polygonal portion. On top is a non- functional reconstructed cupola.

8 March 1901. pp. 967-980. Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles. From 30 November 2015, the government no longer referenced counties and parishes in land information systems however the Museum of Lands, Mapping and Surveying retains a record for historical purposes.

Other causes of splenomegaly (for example, Gaucher disease or hemoglobinopathies) can also predispose to infarction. Splenic infarction can also result from a sickle cell crisis in patients with sickle cell anemia. Both splenomegaly and a tendency towards clot formation feature in this condition. In sickle cell disease, repeated splenic infarctions lead to a non- functional spleen (autosplenectomy).

Adaptive architecture is a system which changes its structure, behaviour or resources according to demand. The adaptation made is usually [always?] to non-functional characteristics rather than functional ones. Something of a misnomer, because the thing that adapts is the working system, rather than the (more abstract) architecture which defines the adaptability that is required of that system.

This approach is known as pure aspect programming, but hybrid approaches are more commonly used, perhaps since there is less of a paradigm shift between object- and aspect-oriented programming. There is a similar situation with early aspect software development (e.g., requirements), with traditional methods being enhanced for aspect-orientation and new models proposed. Non-functional concerns (e.g.

These innate processes direct heterosexual copulation.MEISEL Robert L. , SACHS Benjamin D. : The physiology of male sexual behavior. in KNOBIL Ernest, NEILL Jimmy D. The physiology of reproduction, Raven Press, 2nd edition, 1994 Female lordosis behaviour became secondary in hominidae and is non-functional in humans.Dixson A.F. Primate sexuality: Comparative studies of the Prosimians, Monkeys, Apes, and Human Beings.

The teeth of plankton-feeders, such as the basking shark and whale shark, are greatly reduced and non-functional. These sharks filter feed on prey by opening their mouths to let tiny organisms get sucked into their mouths to feed without using their teeth at all, instead filtering the food when passing water through their gills.

The adult male is laterally compressed and about long. It has very short antennae, and a large, shield-like pronotum which conceals tiny, vestigial wings. The femora are well-developed and the abdomen sharply upturned. The female is double the size of the male, broader and more heavily-built, and also has small, non- functional wings.

The landscape of Roseberry County The County of Rosebery is a county (a cadastral division) in Queensland, Australia. It is centred in the South Gregory Lands District. Like all counties in Queensland, it is a non- functional administrative unit, that is used mainly for the purpose of registering land titles.Maranoa District, County of Belmore Maps - R1 Series at Queensland Archives.

Functional sizing can also contribute to determining the level of effort warranted once an application is deployed. The IFPUG membership, functional and non-functional assets and certifications, and IFPUG partners assist in fulfilling IFPUG's mission: to be the recognized leader in promoting and encouraging the effective management of application software development and maintenance activities through the use of software product and process metrics.

During the Ming dynasty, civil service officials were classified into nine grades, each grade subdivided into two degrees, extending from grade 1a at the top to grade 9b at the bottom.Hucker, 11. For example, the top-ranking, non-functional civil service posts of the Three Councillors of State had rank 1a,Hucker, p. 17. so did the office of Chancellor.

The yearly budget of NPR 27 Crore (about US$ 2.371 million), two thirds of which is funded by the government. Nepalnews.com Mercantile Communications Pvt. Ltd The hospital has been facing financial difficulties for many years now. The lack of adequate funding, non-functional equipment and inability of the administration to get those running pose significant challenges to the hospital's functioning.

He has a pair of handheld knives stored under his sleeves. :His Assist Weapon form is , a yellow twin-driller subterrene armed with and . Despite the existence of his , his teammates proclaimed them as non-functional in combat. ; : (Japanese); Chris Burnett (English) :A man with a laid-back attitude who is named after the Vitor fighter jet from Superhuman Samurai Syber-Squad.

The term occurs mainly in popular science and in a colloquial way in scientific publications, and it has been suggested that its connotations may have delayed interest in the biological functions of non- coding DNA. Some evidence indicate that some "junk DNA" sequences are sources for (future) functional activity in evolution through exaptation of originally selfish or non-functional DNA.

Ballantyne, 2013, p. 51. The rangefinders and the transmission station were non-functional and only "A" turret could fire, albeit under local control with 12 salvos falling short of their target. Sub Lieutenant Herbert Annesley Packer was subsequently promoted for his command of "A" turret. Rather than continue, Warspite was stopped for ten minutes so the crew could make repairs.

It was available on any model. The SS performance package consisted of a or V8s and chassis upgrades for better handling and to deal with the additional power. The SS featured non-functional air inlets on the hood, special striping, and SS badging. The Z/28 performance package was designed (with further modifications) to compete in the SCCA Trans-Am Series.

In some cases it even became non- functional, with a concealed opening beneath it and the original jacket opening becoming a false detail. By the later 19th century, for lower grade uniforms down to postmen, telegraph boys and hotel pages, the frogging cordage would be retained as a decoration but there would be no corresponding toggle or opening with it.

Fixed and operable louvers shed rain, allow air transfer, filter direct sunlight, protect from small flying debris, and provide privacy. Operable louvered shutters allow for greater control of light and ventilation. Solid panels and board-and-batten shutters are generally used for security or protection during severe weather. Non-functional shutters are merely used to enhance the appearance of a building.

The library of the school had remained non-functional for a long time because of the absence of a librarian at the school. It was reopened under the control of Prabir Kr. Gope, an Assistant teacher. Old books have been restored by subsequently. At presenta Library Committee headed by an assistant teacher keeps the library going and lending and reading facilities are available.

Within the Neuropterida, adults have chewing mouthparts, but the mandibles of male dobsonflies are non-functional in feeding. The larvae in many lineages are predatory, with mandibles modified with grooves along which digestive saliva flows, while the larvae of the family Sisyridae have the mouthparts developed into a sucking tube which they use to feed on the liquid tissues of freshwater sponges.

As larve (ammocoetes), the northern brook lamprey are filter feeders; feeding primarily on detritus, zooplankton, algae, diatoms, bacteria, pollen and a host of other microorganisms as they remain burrowed in fine substrate in calm waters. The juveniles and adults have non-functional intestines and do not feed; juveniles drift for 4–6 months and the adults spawn and die shortly after spawning.

The GXP has an upgraded, Nürburgring-tuned FE3 suspension package, as well as larger, ventilated Brembo disc brakes. It also features a unique front bumper cover and a rear (non-functional) diffuser to differentiate it from the standard Sedan and GT models. Total sales of the Pontiac G8 GXP were 1,829 units. Only a limited production of G8 GXP were available in Canada.

National Highway 44 runs from Guwahati-Shillong in the northeast to center and then to west towards Agartala. Work had begun but currently stopped for National Highway 44-A connecting Manu to Aizawl, Mizoram. The district has meter gauge rail connectivity on the Lumding-Agartala line with stations at Manu, and Ambassa. There is a non-functional airstrip at Kamalpur.

Queensland Government Gazette. 75. 8 March 1901. pp. 967-980. Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles. From 30 November 2015, the government no longer referenced counties and parishes in land information systems however the Museum of Lands, Mapping and Surveying retains a record for historical purposes.

As a consequence of 2018 Kerala floods, the airport was closed 1429 August 2018. Water in the Periyar, which flows away from the airport, rose to during these days. The runway and other facilities were non-functional due to excessive flooding and inclement weather. Flights to Kochi were diverted to and were operating from other airports in the state like Thiruvananthapuram and Kozhikode.

It should include some consideration of any user interfaces as well, without going into excessive detail. Any non-functional system requirements (response time, reliability, maintainability, etc.) need to be considered at this stage. The software architecture is also of interest to various stakeholders (sponsors, end-users, etc.) since it gives them a chance to check that their requirements can be met.

ErbB3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. ErbB3 can heterodimerize with any of the other three ErbB family members. The theoretical ErbB3 homodimer would be non-functional because the kinase-impaired protein requires transphosphorylation by its binding partner to be active.

It has calyptrate flower petals and the pistils are non-functional in male flowers. Its berries are usually 6–0 mm. in diameter, and darkly purple to black. A holotype specimen was first collected of this species by E. H. Wilson from Xingshan Xian, in Hubei province, China in June 1907, who said it was 'climbing or prostrate over rocks, 600–1200 m.

Vitásek had three previous criminal convictions, including one for a violent crime. He had also been hospitalized in a psychiatric ward. Both of these factors rendered him ineligible to legally possess a firearm in the Czech Republic. Vitásek used a CZ 75 pistol that was made about 30 years before as a non-functional cut-away replica for purposes of education and training.

She attended the Massachusetts College of the Arts in Boston where she studied under Ernest Lee Major. Huntington married Raymond Edwards Huntington on June 9, 1909 in Wollaston, Massachusetts. During their engagement, Elizabeth was diagnosed with polio that paralyzed the right side of her body. In order to continue painting she had to manipulate her non- functional right arm using her left arm.

Some infants born with autosomal recessive SCIDS lack a functional copies of the genes that code for the RAG1/RAG2 enzyme complex because of missense mutations. These infants will produce a non-functional RAG1/RAG2 enzyme complex that cannot recognize RSSs and therefore cannot initiate V(D)J recombination effectively. This disorder is characterized by a lack of functioning B and T cells.

Examples include formatting text, calculating a number, modulating a signal. They are also sometimes known as capabilities. ; Quality-of-service (non-functional) requirements : Usually detailed statements of the conditions under which the solution must remain effective, qualities that the solution must have, or constraints within which it must operate.Ralph, P., and Wand, Y. A Proposal for a Formal Definition of the Design Concept.

The main crops harvested in the district are paddy, wheat, pulses, and vegetables. Industrial facilities in the district include bidi factories and silk handlooms. Formerly, sugar cane farming and processing also took place; the district's single sugar mill, located in Warisaliganj, is currently non-functional. Kadirganj, located 10 km from Nawada, has a silk small scale industry where workers clean and weave silk.

A young girl looks at David Oliviera's "Wire Scribble Sculpture" at an IMoDD exhibition. Along with contemporary and historic dinnerware, IMoDD collects non-functional fine art that references the dining experience, including art made by Roy Lichtenstein, Sandy Skoglund ("The Cocktail Party"), William Parry ("Knife Fork Spoon" ceramic sculpture), and David Oliviera ("Wire Scribble Sculpture"). IMoDD has over 8,500 objects in its collection.

The ParM monomer unit is non-functional before binding a GTP nucleotide. Once the GTP has been bound it can attach to the end of a growing filament. At some point after attachment the ParM hydrolyzes GTP which becomes GDP and remains in the ParM subunit as long as the polymer strand remains intact. ParM forms a left-handed helix structure.

Fossil shark teeth (Cretaceous) from southern Israel. Elementorum myologiae specimen, 1669 A shark tooth is one of the numerous teeth of a shark. Sharks continually shed their teeth; some Carcharhiniformes shed approximately 35,000 teeth in a lifetime, replacing those that fall out. There are four basic types of shark teeth: dense flattened, needle-like, pointed lower with triangular upper, and non-functional.

To allow identification during production most silicon chips will have a serial number in one corner. It is also common to add the manufacturer's logo. Ever since ICs were created, some chip designers have used the silicon surface area for surreptitious, non-functional images or words. These are sometimes referred to as chip art, silicon art, silicon graffiti or silicon doodling.

This starfish has ten to fourteen long tapering arms with distinctive large eyespots on the tips. These are each composed of about a hundred complex ocelli; on close examination these structures were found to be virtually devoid of sensory structures and may be non-functional. The disc and arms of this starfish are clad in spines, themselves armed with pedicellariae (small claw or wrench- shaped organs).

A non-functional replica of the California Zephyr was displayed at Disney California Adventure Park in Anaheim, California. It housed Baker's Field Bakery and Bur-r-r Bank ice cream counter cafes at the Sunshine Plaza main entrance. The exhibit closed on July 31, 2011, as part of the park's $1.1 billion overhaul. Disney gave the replica to the Western Pacific Railroad Museum in Portola, California.

Despite the diversity of protein superfamilies, sequence space is extremely sparsely populated by functional proteins. Most random protein sequences have no fold or function. Enzyme superfamilies, therefore, exist as tiny clusters of active proteins in a vast empty space of non-functional sequence. The density of functional proteins in sequence space, and the proximity of different functions to one another is a key determinant in understanding evolvability.

Comparisons of fragmented DNA sequences from different strains showed that all capripoxviruses have a very similar nucleotide sequence homology. Strains were also proven to not all be host-specific. All Capripoxvirus DNA are double-stranded with lengths of around 150 kbp. Strains from goatpox and sheeppox share at least 147 genes; LSDV have an extra 9 genes that are non-functional in GTPV and SPPV.

Starting out, Fields began making non- functional sculptures, such as little figurines. Fields made an entire series of little clay boxes with smaller clay figures inside of them. During this period, Fields developed a lot of her work through the process of terra sigillata. Anita's work is usually fired in an electric kiln and finished by a postsmoking process with sawdust, straw, or leaves.

Of the MoUs, an MoU will be signed on the import of wheat from Iran, officials said. An MoU on agriculture sector signed at the 2013 meeting will be extended till 2020. About the PTA, officials said the countries have failed to settle dispute of rules of origin of products in last nine years of signing of the agreement, which has kept it non-functional.

See Figures 4 & 5 for Pulse Life Curves.. Every time an MOV activates (shorts,) its threshold voltage reduces slightly. After many spikes the threshold voltage can reduce enough to be near the protection voltage, either mains or data. At this point the MOV conducts more and more often, heats up and finally fails. In data circuits, the data channel becomes shorted and non-functional.

Application Performance Engineering (APE) is a specific methodology within performance engineering designed to meet the challenges associated with application performance in increasingly distributed mobile, cloud and terrestrial IT environments. It includes the roles, skills, activities, practices, tools and deliverables applied at every phase of the application lifecycle that ensure an application will be designed, implemented and operationally supported to meet non-functional performance requirements.

The enzyme RuBisCo has its own, more complex activation process. It requires that a specific lysine amino acid be carbamylated to activate the enzyme. This lysine binds to RuBP and leads to a non-functional state if left uncarbamylated. A specific activase enzyme, called RuBisCo activase, helps this carbamylation process by removing one proton from the lysine and making the binding of the carbon dioxide molecule possible.

It has been identified many different isoforms of MR1, many of them have premature terminating codon generating non-functional proteins. MR1B isoform lacks α3 domain. α3 domain is interacting with β2 microglobulin, this interaction and bounded antigen stabilize the whole MHC I molecule. In a case of MR1B is β2 microglobulin not needed for stabilized structure and MR1B is expressed on the cell surface.

A studio potter is one who is a modern artist or artisan, who either works alone or in a small group, producing unique items of pottery in small quantities, typically with all stages of manufacture carried out by themselves.Emmanuel Cooper, Ten Thousand Years of Pottery. British Museum Press, 2000. . Studio pottery includes functional wares such as tableware, cookware and non-functional wares such as sculpture.

HanaHo Games Inc is a division of Semco/PVG that services the commercial coin- op industry. HanaHo primarily produced the HotRod arcade joystick. They also sold a line of non-coin-operated PC game machines (the machines had a coin door, but it was non-functional) that included 50 game titles from Capcom. The company was started by Tony Hana and Conway Ho (hence the name Hanaho).

Volume 2, p. 23, London 1878. While the current structure referred to as Mary's Well is a non-functional reconstruction inaugurated as part of the Nazareth 2000 celebrations, the traditional Mary's Well was a local watering hole, with an overground stone structure. Through the centuries, villagers would gather here to fill water pitchers (up until 1966) or otherwise congregate to relax and exchange news.

Perth Town Hall was the council seat from 1871 to 1925. Council House has been the council seat since 1963. In 1829, Captain James Stirling founded Perth as part of the Swan River Colony. A Perth Town Trust was formed in 1832, but remained largely non-functional for many years due to lack of finance and adminstrative capacity leading to its dissolution in 1858.

8 March 1901. pp. 967-980. Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles. From 30 November 2015, the government no longer referenced counties and parishes in land information systems however the Museum of Lands, Mapping and Surveying retains a record for historical purposes. The center of local government is Burketown.

The gall will enlarge for 2 years and sporulate on the third. Spermogonia ooze from infected bark in early spring, but they are non-functional since they do not form aecia (vestigial). Dikaryotization of the haploid mycelium that produce the teliospores takes place in the outer cortex, just beneath the first periderm. They are surrounded by a membrane called a peridium that bursts, releasing the spores.

The forelimbs were smaller than the hindlimbs. The hand bore two large, clawed digits and a third, smaller digit that may have been non-functional. Their delicate skulls were narrow and long, with tapered snouts. The skull had five pairs of fenestrae (skull openings), the largest of which was for the orbit (eye socket), with the eyes being larger in proportion to the rest of the skull.

The work in the touring exhibition 'Layers' represented a fundamental departure for Stead in a number of respects. This was the first exhibition composed exclusively of non-functional, sculptural pieces- and in a gallery setting. 'Layers' was first shown at the Compass Gallery, Glasgow in 1990.'layers. an exploration in wood by Tim Stead' Exhibition Catalogue, Compass Gallery All the 'Layers' pieces carried an invitation – 'Please Touch'.

Nvidia's nForce4 chipset suffers from several unresolved issues. The ActiveArmor hardware firewall is nearly non-functional, with many unsolved bugs and potentially serious instability issues. Installing ActiveArmor can cause BSODs for users of certain software, especially peer-to-peer file sharing applications. Some programs, such as μTorrent, go so far as to have warning messages about using Nvidia's firewall in combination with their software.

Requirements and principles deal with determining the business drivers and guiding principles that help in the development of the enterprise architecture. Each functional and non-functional requirement should be traceable to one or more business drivers. Organizations are beginning to become more aware of the need for capturing and managing requirements. Use-case modeling is one of the techniques that is used for doing this.

2, 31.3.2.1. Leucocitozele; A leukocyte count above 25 to 30 × 109/L is termed a leukemoid reaction, which is the reaction of a healthy bone marrow to extreme stress, trauma, or infection. It is different from leukemia and from leukoerythroblastosis, in which either immature white blood cells (acute leukemia) or mature, yet non-functional, white blood cells (chronic leukemia) are present in peripheral blood.

Kaiping Zeng, Sorin A. Huss, "Architecture refinements by code refactoring of behavioral VHDL-AMS models". ISCAS 2006 In their approach, refactoring preserves the simulated behavior of a hardware design. The non- functional measurement that improves is that refactored code can be processed by standard synthesis tools, while the original code cannot. Refactoring of digital HDLs, albeit manual refactoring, has also been investigated by Synopsys fellow Mike Keating.

Often pre-restored vehicle have engines that have gone without maintenance for years and therefore require engine restoration to return them to working order. The engine is removed from the car and inspected for broken and non- functional parts. Typical parts that require replacing include the pistons, spark plugs, fuel lines, battery, fuses, timing belt and various gaskets. All are subject to deterioration over time.

How is it possible then to ensure that the illustrated design on paper would indeed render a stable production landscape? The term "stable" means that the deployed systems would meet business and non-functional requirements. The promise of the Incremental Software Architecture, therefore, is rooted in the chief principle, “First Design then Develop.” But this alone is short of avoiding financial burden caused by failing implementations.

Dynamic testing involves running the software. Static testing includes verifying requirements, syntax of code and any other activities that do not include actually running the code of the program. Testing can be further divided into functional and non-functional testing. In functional testing the tester would check the calculations, any link on the page, or any other field which on given input, output may be expected.

1953 Hudson Hornet Hollywood Hardtop The 1953 model year brought minor changes to the Hudson Hornet. The front end was modified with a new grille and a non- functional air scoop hood ornament. four different body designs: two-door club coupe, Hollywood hardtop, Convertible Brougham, and a four-door sedan. Hudson Hornet 1953 model year production totaled 27,208 units of which around 910 were the Hollywood hardtops.

The Fitbit Charge 3 was released in October 2018. It has a heart rate sensor as well as an oxygen saturation (SPO2) sensor - however, it is non-functional and Fitbit has yet to give a timeline for the feature to be enabled. Sleep tracking has been improved from the Charge 2. In November 2018, a special edition of the Fitbit Charge 3 was released featuring "Fitbit Pay" as a special feature.

Waste Management characterized the ERP implementation as non-functional. An SAP sponsored "Solution Review" determined that a customized ERP, based upon an updated SAP ERP, would need to be made in order to accommodate a company-wide implementation. Waste Management sued SAP for the US$100 million to recover the funds it had spent on the failed ERP implementation. In the lawsuit, Waste Management accused SAP of fraud and deception.

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009].

The wall is roughly plastered and there remains a now non- functional round tower at two of the western corners. On the inside runs a footpath along the wall. This path offers an interesting alternative far from the hustle and bustle of tourism, since this path shows the palace park from its unkept side. The path, that can't be found on official maps has a total length of .

The pectoral muscles were chosen targets because they were close to the shoulder, and they were also biologically non-functional due to detachment from the amputated arm. The pectoral muscles were first denervated by cutting the original nerves that innervate them. The proximal ends of the original nerves were ligated to prevent them from reinnervating the pectoral muscle. Then the remnant arm nerves (brachial plexus) were transferred into the pectoral muscles.

Bennett Bean pair of painted, glazed, white earthenware pottery with 14k gold leafBennett Bean (born March 25, 1941) is an American ceramic artist. Although commonly described as a studio potter, some would characterize him as a sculptor and painter who works primarily in studio pottery. Bean resides in Frelinghuysen Township, New Jersey. Bean is best known for his pit fired white earthenware vessels, especially his collectible, non-functional bowls and teapots.

The chorismate binding site on PabB consists of amino acids residues that make up beta sheet core and the two key alpha helices. Certain aminodeoxychorismate synthase enzymes contain an additional binding site for tryptophan, thought to be a non-functional vestigial binding site. It is believed that aminodeoxychorismate synthase may have evolved from anthranilate synthase (TrpE) - an enzyme that catalyses the production of an intermediate on the path to tryptophan.

Mutated KAL1 genes leads to ill GnRH neuronal migration as well as olfactory neuron disorder causing anosmia and non-functional GnRH releasing neurons. Mutations of KAL1 are mostly nucleotide insertion or deletion causing frame shifts in the translation of anosmin-1 resulting in a faulty protein. Inactivating mutations in the genes encoding GNRH1 or its receptor will result in the failure of the HPG axis and give rise to normosmic CHH.

One of the characteristic feature of streblid bat flies is their variable degree of eye reduction. The compound eyes are highly, but variably reduced, with some species containing only rudimentary eye spots. Ocelli are absent in all species. Wing morphology also significantly varies within the family with some species containing fully functional wings, while others contain either reduced (non functional or functional) wings or no wings at all.

More than 60 percent of the genes in this family are non-functional pseudogenes in humans. By comparison, only 20 percent of genes in the mouse olfactory receptor gene family are pseudogenes. Research suggests that this is a species-specific characteristic, as the most closely related primates all have proportionally fewer pseudogenes. This genetic discovery helps to explain the less acute sense of smell in humans relative to other mammals.

Nematomorphs possess an external cuticle without cilia. Internally, they have only longitudinal muscle and a non-functional gut, with no excretory, respiratory or circulatory systems. The nervous system consists of a nerve ring near the anterior end of the animal, and a ventral nerve cord running along the body. Reproductively, they have two distinct sexes, with the internal fertilization of eggs that are then laid in gelatinous strings.

There is an emphasis on unusual bicycles, first and foremost the children's bicycles or "minibikes," but extending to tall bikes, swing bike, choppers, non-functional bicycles, skateboards, longboards, etc. The Zoobombers are made up of a wide demographic, with a tendency towards young adults. The event is treated in a very lighthearted fashion, including a large amount of socializing between rides. Riders often dress up in costume or decorate their bicycles.

However, about 30% of cases have no identifiable causative mutation. It is estimated that between 55-80% of cases of Kabuki syndrome are caused by mutations in the KMT2D gene, formerly known as the MLL2 gene. This gene is located on chromosome 12. A mutation in the KMT2D gene results in a non functional lysine (K)-specific methyltransferase 2D enzyme and demonstrates an autosomal dominant pattern of inheritance.

She created an extensive sculpture series, "Birdhouse as Metaphor," which consisted of numerous functional and non-functional birdhouses and showed in 1990 at Souyun Yi Gallery. In 1997, Close Encounters, a volume of Foreman's short stories, was published by Outloud Books. Foreman died of cancer in Manhattan in 2001.Dunning, Jennifer "Laura Foreman, 64, Director of Dance at The New School", The New York Times, July 5, 2001.

The renovation, costing more than $1 million, began in May 1993, with the demolition of an east-facing wall. The expansion was to add , including a three-story façade, with the third floor being non-functional. Other plans included a 38-foot lighted exterior sign, two new entrances, 100 new slot machines, and a new southwestern theme. A grand reopening was scheduled for August 2, 1993, the casino's four-year anniversary.

There are considerable overlaps between the terms clothing-/garment-, textile- and fashion industry. The clothing sector is concerned with all types of clothes, from fashion to uniforms, e-textiles and workwear. Textile industry is less concerned with the fashion aspect but produces the fabrics and fibres that are required for tailoring. The fashion industry closely follows - and sets - fashion trends to always supply the latest in non-functional clothing.

The court did not expressly decide whether Beauregard claims are patent-eligible. Consequently, such computer- readable media claims are commonly referred to as Beauregard claims. When first used in the mid-1990s, Beauregard claims held an uncertain status, as long-standing doctrine held that media that contained merely "non-functional" data (i.e., data that did not interact with the substrate on which it was printed) could not be patented.

The second known mutation in SCN2A associated with GEFS+ is R102X. This mutation is located in the intracellular N-terminus (figure 3) and results in SMEI in patients. The result of this mutation is completely non-functional channels and membrane hypoexcitability. The truncated mutant protein also seems to cause wild-type channels to inactivate at more hyperpolarized potentials, indicating that it also acts in a dominant negative manner.

The language could then encompass any or all of the above techniques as required by the problem at hand.Structure and Interpretation of Computer Programs, Part 4 — Metalinguistic Abstraction Because the creation of functional metalinguistic abstractions in non- functional languages can be cumbersome while the reverse is usually trivial, and also because of the syntactic flexibility and referential safety of functional macros, metalinguistic programming is mostly idiomatic of functional programming languages.

The capitulum of Ixodes holocyclus The capitulum of Ixodes holocyclus (scanning electron microscopy) The feeding process of Ixodes holocyclus Ticks generally are obligate blood feeders. All active stages (larvae, nymphs and adults) require blood as a source of nutrition (except for a few Argasid genera in which the adult mouthparts are non-functional, i.e. Antricola, Otobius and Nothoaspis). Adults also require the blood for sperm or egg production.

When the computation of the graph is concluded, the result is placed into the output stream and thus delivered back to the user. Muskel also provides non-functional features such as Quality of Service (QoS);M. Danelutto. "Qos in parallel programming through application managers." In PDP '05: Proceedings of the 13th Euromicro Conference on Parallel, Distributed and Network-Based Processing (PDP'05), pages 282–289, Washington, DC, USA, 2005.

194–195 In bitonal passages, melodies may be consonant within a harmonic area, but not with those from the other one.Abrahams, p. 206 Abrahams characterises Sorabji's writing as having a "disembodied quality" resulting from the use of non-functional harmony, in which no key or bitonal relationship is allowed to become established. This lends flexibility to his harmonic language and helps justify the superimposition of semitonally opposed harmonies.

There are several additional organelles found in the cytoplasm of Symbiodinium. The most obvious of these is the structure referred to as the "accumulation body". This is a membrane-bound vesicle (vacuole) with contents that are unrecognizable, but appear red or yellow under the light microscope. It may serve to accumulate cellular debris or act as an autophagic vacuole in which non-functional organelles are digested and their components recycled.

When the fans finally meet Ron Cole, their hopes are crushed. The rocket is a decaying wreck, and Cole is a shadow of his former self due to invasive 'reeducation' treatments. However, Cole is able to put them on another path - a privately constructed single-stage-to-orbit spacecraft at Edwards Air Force Base, disguised by the simple and effective method of its designer, Gary Hudson, declaring it non-functional.

Operational acceptance testing (OAT) is used to conduct operational readiness (pre- release) of a product, service or system as part of a quality management system. OAT is a common type of non-functional software testing, used mainly in software development and software maintenance projects. This type of testing focuses on the operational readiness of the system to be supported, and/or to become part of the production environment.

The 240SX received some updates in 1991. The matte silver, teardrop wheels were replaced by polished aluminium 7-spoke wheels that had better brake cooling properties but more drag. The nose was smoothed out by getting rid of the non-functional slots and gave back the aerodynamic efficiencies lost by the wheels. This gave the car an overhaul that included a minor update of the exterior and a new cylinder head.

A bespoke fuel tank and wiring loom were also commissioned. Although the car had front and rear double wishbone independent suspension from a 400 GT installed from the beginning, suspension modifications were required to make it road-usable, including adjustment of ground clearance and replacement of non-functional springs. The conversion process took approximately 1.5 years. The car first ran in March 2010, some 30 years after its first appearance.

The [psi+] strain appears white even when subjected to the same non-sense mutations. Thus, it is inferred that the eRF3 of the [psi+] is non-functional. This phenomenon is because the eRF3 in [psi-] is able to disconnect the ribosome effectively, so the enzyme cannot be properly synthesized. However, in the [psi+] strain, the enzyme is able to be synthesized enough so that the pathway still successfully produces adenine.

In metazoans, NUMTs are considered non- functional. Therefore, nuclear mutations can be distinguished from mitochondrial changes and the study of nucleotide substitution, insertion, and deletion would be possible. Additionally, the homology of paralogous NUMT sequences with the mtDNA allows testing for local sequence effects on mutation. All these information obtained from the study of NUMT fragments could be used to understand mitochondrial evolution as well as evolutionary processes throughout the history.

These tests can be functional or non-functional, though usually functional. Specification-based testing may be necessary to assure correct functionality, but it is insufficient to guard against complex or high-risk situations. One advantage of the black box technique is that no programming knowledge is required. Whatever biases the programmers may have had, the tester likely has a different set and may emphasize different areas of functionality.

One approach to iterative design is to use the highest level of abstraction for developing an early generation product. The principle here is that rapid development may not produce efficient code, but obtaining feedback is more important that technology optimization. Examples of this approach include use of non-functional code, object databases, or low code platforms - these allow quick testing of designs before issues of optimization are addressed.

Rishi, longing for his father's wealth, decides to travel towards the orphanage with his best friend, Jerry. To their surprise, they discover that the orphanage is non-functional. To get the money, the orphanage has to be functioning well, so they contact Lenin (Sharaf U Dheen), a political party worker, and befriend him. The three of them together rescue kidnapped children on the road by disguising themselves as the police.

A fetus receives oxygen not from its lungs, but from the mother's oxygen-rich blood via the placenta. Oxygenated blood from the placenta travels through the umbilical cord to the right atrium of the fetal heart. As the fetal lungs are non-functional at this time, the blood bypasses them through two cardiac shunts. The first is the foramen ovale which shunts blood from the right atrium to the left atrium.

A pharaoh ant worker near the tip of a ball point pen Pharaoh workers are about 1.5 to 2 millimeters long, a little more than 1/16-inch. They are light yellow to reddish brown in color with a darker abdomen. Pharaoh ant workers have a non-functional stinger used to generate pheromones. The petiole (narrow waist between the thorax and abdomen) has two nodes and the thorax has no spines.

Lateral view of the adult beetle Adult females are range between 1.9 and 2.5 mm long. They are bulky, dark brown or black and the frontal edge of the pronotum has a row of saw-like projections. Moreover, specimens have erect setae organized in rows in the elytral declivity with a costa in the posterolateral edge. As many other ambrosia beetles, males are significantly smaller, with non-functional wings.

Nash four-door sedan with factory color-matched Continental tire A Continental tire or a Continental kit is an upright externally-mounted spare tire located behind an automobile's trunk, made popular by the original Lincoln Continental. The term also describes a non-functional bulge that is stamped into the trunk lid or a cosmetic accessory to the rear of the car giving the impression of a spare tire mount.

The County of Churchill is a county (a cadastral division) in Queensland, Australia. Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles. The county lies between 152°E and 153°E longitude, and is centred on the West Moreton region, extending east to the suburbs of Ipswich.Moreton District, County of Churchill Maps - A4 Series at Queensland Archives.

Regression testing (rarely non-regression testing) is re-running functional and non-functional tests to ensure that previously developed and tested software still performs after a change. If not, that would be called a regression. Changes that may require regression testing include bug fixes, software enhancements, configuration changes, and even substitution of electronic components.National Research Council Committee on Aging Avionics in Military Aircraft: Aging Avionics in Military Aircraft.

The exploration of consciousness is the central thematic element of Blindsight. The title of the novel refers to the condition blindsight, in which vision is non-functional in the conscious brain but remains useful to non-conscious action. Other conditions, such as Cotard delusion and Anton–Babinski syndrome, are used to illustrate differences from the usual assumptions about conscious experience. The novel raises questions about the essential character of consciousness.

Thus functional saturated/monounsaturated PA can be degraded by hydrolysing it to form non-functional saturated/monounsaturated DAG, whereas functional polyunsaturated DAG can be degraded by converting it into non- functional polyunsaturated PA. This model suggests that PA and DAG effectors should be able to distinguish lipids with the same headgroups but with differing acyl chains. Although some lipid-binding proteins are able to insert themselves into membranes and could hypothetically recognize the type of acyl chain or the resulting properties of the membrane, many lipid-binding proteins are cytosolic and localize to the membrane by binding only the headgroups of lipids. Perhaps the different acyl chains can affect the angle of the head- group in the membrane. If this is the case, it suggests that a PA-binding domain must not only be able to bind PA specifically but must also be able to identify those head-groups that are at the correct angle.

Mutations in GNAT2 tend to result in a truncated and, presumably, non-functional protein, thereby preventing alteration of cGMP levels by photons. There is a positive correlation between the severity of mutations in these proteins and the completeness of the achromatopsia phenotype. Molecular diagnosis can be established by identification of biallelic variants in the causative genes. Molecular genetic testing approaches used in achromatopsia can include targeted analysis for the common CNGB3 variant c.

The ears of a macaque monkey and most other monkeys have far more developed muscles than those of humans, and therefore have the capability to move their ears to better hear potential threats.Prof. A. Macalister, Annals and Magazine of Natural History, vol. vii., 1871, p. 342. Humans and other primates such as the orangutan and chimpanzee however have ear muscles that are minimally developed and non- functional, yet still large enough to be identifiable.

Understood in presently prevailing terms the two are clearly incompatible, as the former identified divine order and the latter the people as a source of public power.see e.g. La actualidad del Dios-Patria- Rey, [in:] Boletin carlista de Madrid 69 (2002), referred after Bartyzel 2015, p. 124 Also in terms of praxis most Traditionalists generally rejected democracy as unstable and non-functional systemaccording to the Persians democracy was an unstable system, Fernández García 2014, p.

The historic ramp at the Islandia Marina camp in Kino Viejo has fallen into disrepair and is non-functional. There is open anchorage located to the south of Isla Alcatraz. The large Laguna La Cruz to the south east of town offers excellent anchoring and protection with access to town via a well maintained dirt road. An unmarked channel allows vessels drawing less than 2 meters easy access to this anchorage from the bay.

IFPUG maintains the Function Point Counting Practices Manual (CPM), and the SNAP Assessment Practices Manual, the recognized industry standards for functional and non-functional sizing. IFPUG provides testing and certification for the Certified Function Point Specialist (CFPS), the Certified Function Point Practitioner (CFPP), and the Certified SNAP Practitioner (CSP). Generally, certification is for three years although the CFPS has a certification extension program. IFPUG offers individual, corporate, countrywide, worldwide, and academic memberships spanning six continents.

An irreversible antagonist is a type of antagonist that binds permanently to a receptor, either by forming a covalent bond to the active site, or alternatively just by binding so tightly that the rate of dissociation is effectively zero at relevant time scales.Goodman and Gilman's Manual of Pharmacology and Therapeutics. (11th edition, 2008). p25. This permanently deactivates the receptor and is usually followed by rapid internalisation and recycling of the non-functional receptor protein.

Allelic variation in these loci have been associated with flowering time variations between plants. For example, Arabidopsis thaliana ecotypes that grow in the cold temperate regions require prolonged vernalization before they flower, while the tropical varieties and common lab strains, do not. Much of this variation is due to mutations in the FLC and FRIGIDA genes, rendering them non-functional. Many genes in the flowering time pathway are conserved across all plants studied to date.

In the search for an explanation for this rarity, it has been found that the patient has a seldom-seen allelic combination. One allele is a non-functional null allele, while the other encodes for a partially active enzyme. Furthermore, the partially functional allele has expression deficits that depend on the cell type in which it is expressed. Therefore, some of the patient's cells have a considerable amount of Rpi activity, whereas others do not.

Tooth shape depends on the shark's diet: those that feed on mollusks and crustaceans have dense and flattened teeth used for crushing, those that feed on fish have needle-like teeth for gripping, and those that feed on larger prey such as mammals have pointed lower teeth for gripping and triangular upper teeth with serrated edges for cutting. The teeth of plankton-feeders such as the basking shark are small and non-functional.

On 12 August 1937 Pearson formed one large airline called Scottish Airways. He brought in investment from LMS Railway, and from David MacBrayne, the Scottish ferry company which established Western Isles Airways as its investment tool. They brought N&SA; and Highland Airways into the new airline. To avoid confusion with Scottish Airways the company was renamed Northern Airways Limited on 6 September 1937 and it became a non-functional holding company.

A molecular genetic approach is the creation of transgenic organisms that overexpress a normal gene of interest. The resulting phenotype may reflect the normal function of the gene. Alternatively it is possible to overexpress mutant forms of a gene that interfere with the normal (wildtype) gene's function. For example, over-expression of a mutant gene may result in high levels of a non-functional protein resulting in a dominant negative interaction with the wildtype protein.

There are two subtypes of HH, congenital HH (CHH) and acquired HH (AHH). CHH is due to genetic abnormalities resulting in non-functional GnRH secreting neurons or gonadotropic cell dysfunction in the anterior pituitary. CHH is divided into 2 subtypes depending on the condition of the olfactory system, anosmic HH (Kallman syndrome) and normosmic HH. AHH is an acquired form of the disease often occurring after sexual maturation and is not related to genetic defects.

The DWP accepts that being found fit for work and ineligible for sickness benefit can, in some circumstances, harm a recipient's physical or mental health. For this reason, one of the WCA's eligibility criteria — the non-functional descriptor Substantial Risk — applies where there is, on balance, more than a small risk of harm if the claimant were to be declared 'fit for work'. In these circumstances, the at-risk person should be given the benefit.

In certain cases, one parent will possess the mutated gene only in their egg or sperm cell and the offspring will inherit it through that. This is called germline mosaicism. There are at least 33 mutations in the Sox2 gene that have been known to cause anophthalmia. Some of these gene mutations will cause the Sox2 protein not to be formed, while other mutations will yield a non-functional version of this protein.

His first space flight was in 1990 on STS-41, the 11th flight of Space Shuttle Discovery. He was instrumental in deploying the European Space Agency satellite Ulysses, a solar-exploration craft, as well as tending several secondary payloads and experiments. His next mission was in 1992 on STS-49, the maiden flight of Shuttle Endeavour. A primary goal of that mission was to capture and repair the non-functional Intelsat VI-F3 satellite.

There was something of a marketing war over the number of transistors sets contained, with many models named after this number. Some sets even had non-functional reject transistors soldered to the circuit board, doing absolutely nothing, so the sales pitch could advertise a higher number of transistors. Vacuum tube radios and early transistor radios were hand assembled. Today radios are designed with the assistance of computers and manufactured with much greater use of machinery.

In approximately 10% of CF cases, the mutation in this gene causes its early termination during translation, leading to the formation of is truncated and non-functional CFTR protein. It is believed that gentamicin distorts the structure of the ribosome-RNA complex, leading to a mis-reading of the termination codon, causing the ribosome to "skip" over the stop sequence and to continue with the normal elongation and production of the CFTR protein.

Human Immunodeficiency virus uses CCR5 receptor to target and infect host T-cells in humans. It weakens the immune system by destroying the CD4+ T-helper cells, making the body more susceptible to other infections. CCR5-Δ32 is an allelic variant of CCR5 gene with a 32 base pair deletion that results in a truncated receptor. People with this allele are resistant to AIDS as HIV cannot bind to the non-functional CCR5 receptor.

Dihydrostreptomycin is a derivative of streptomycin that has a bactericidal properties. It is a semisynthetic aminoglycoside antibiotic used in the treatment of tuberculosis. It acts by irreversibly binding the S12 protein in the bacterial 30S ribosomal subunit, after being actively transported across the cell membrane, which interferes with the initiation complex between the mRNA and the bacterial ribosome. This leads to the synthesis of defective non- functional proteins, which results in the bacterial cell's death.

One of the gymnotiforms most specialized to living in deep river channels, O. tamandua resembles fishes adapted to caves in several respects. Their elongated, laterally compressed bodies are nearly unpigmented, appearing bright pink due to the blood underneath. The eyes are tiny and virtually non-functional, and are placed asymmetrically on the head. The asymmetry of the eyes is not correlated with size, sex or environment, but may be related to their degenerate state.

The non-nitrogenous bisphosphonates (diphosphonates) are metabolised in the cell to compounds that replace the terminal pyrophosphate moiety of ATP, forming a non-functional molecule that competes with adenosine triphosphate (ATP) in the cellular energy metabolism. The osteoclast initiates apoptosis and dies, leading to an overall decrease in the breakdown of bone. This type of bisphosphonate has overall more negative effects than the nitrogen containing group, and is prescribed far less often.

Once the cube was covered with colored panels so that it resembled a Rubik's Cube. Similarly, the University of Michigan students covered Endover creating a large Rubik’s Cube on the University of Michigan’s central campus for April fool’s day in 2008. In conjunction with the 2008 April fool’s day cube covering, a student group created a large rotating non-functional Rubik’s Cube for the University of Michigan's North Campus. Built out of 600+ lbs.

Like all non-functional requirements and quality attribute requirements, architecturally significant requirements should be specified in a SMART way. Quality attribute scenarios are one way to achieve the S (specific) and the M (measured) criteria in SMART. The Software Engineering Institute recommends Quality Attribute Workshops for this effort. It has been suggested to keep architecture analysis and design lightweight and flexible; quality attribute trees for certain application genres and technology domains can support such approaches.

Studio pottery is pottery made by amateur or professional artists or artisans working alone or in small groups, making unique items or short runs. Typically, all stages of manufacture are carried out by the artists themselves. Studio pottery includes functional wares such as tableware, cookware and non-functional wares such as sculpture. Studio potters can be referred to as ceramic artists, ceramists, ceramicists or as an artist who uses clay as a medium.

8 March 1901. pp. 969. At this point the southern portion of the County was taken off to form Titheroo County. Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles. From 30 November 2015, the government no longer referenced counties and parishes in land information systems, however the Museum of Lands, Mapping and Surveying retains a record for historical purposes.

Recent studies revealed abilities to solve complicated problems, which suggests high level of innovation of a complex nature. Other corvids that have been observed using tools include the American crow, blue jay and green jay. Researchers have discovered that New Caledonian crows don't just use single objects as tools; they can also construct novel compound tools through assemblage of otherwise non-functional elements. Diversity in tool design among corvids suggests cultural variation.

Positive selection selects cells which are able to bind MHC class I or II molecules with at least a weak affinity. This eliminates (by a process called "death by neglect") those T cells which would be non- functional due to an inability to bind MHC. Negative selection destroys thymocytes with a high affinity for self peptides or MHC. This eliminates cells which would direct immune responses towards self-proteins in the periphery.

The number of non-coding RNAs within the human genome is unknown; however, recent transcriptomic and bioinformatic studies suggest that there are thousands of them. Many of the newly identified ncRNAs have not been validated for their function. It is also likely that many ncRNAs are non functional (sometimes referred to as junk RNA), and are the product of spurious transcription. Non-coding RNAs are thought to contribute to diseases including cancer and Alzheimer's.

Akola Airport (also known as Shioni Airport) is the domestic airport of Akola city and is at an elevation of 999 ft. It was built by the British authorities in the 1940s and regularly sent flights to Mumbai. Now it is non-functional and has one runway (4,600×145 ft). The expansion and functioning of the airport have been delayed as it is unable to get land from Dr. Panjabrao Deshmukh Krishi Vidyapeeth.

This information will lead to a more effective recovery of the medical infrastructure. In 2017 in Adamawa 1120 health facilities were assessed, which included 1 tertiary and 28 secondary hospitals, 363 primary health care centers and 336 primary health care clinics. 12% of them were completely destroyed, 34% – partially damaged and 54% – not damaged. 20% of the 379 partially damaged facilities were fully functional, 63% were partially functional, and 16% were non-functional.

Spasticity Grade 4 to 3+, with or without athetosis or with poor functional range of movement and poor functional strength in all extremities and trunk OR the severe athetoid with or without spasticity with poor functional strength and control. Dependent on a power wheelchair or assistance for mobility. Unable to functionally propel a wheelchair. Lower Extremities-Considered non-functional in relation to any sport due to limitation in range of movement strength and/or control.

On February 6, 2004, the Winklevosses and Narendra first learned of thefacebook.com while reading a press release in the Harvard student newspaper The Harvard Crimson. According to Gao, who looked at the HarvardConnection code afterward, Zuckerberg had left the HarvardConnection code incomplete and non-functional, with a registration that did not connect with the back-end connections. On February 10, 2004, the Winklevosses and Narendra sent Zuckerberg a cease and desist letter.

To create the Super Sport, the original car's windshield, door glass, and windshield wipers were removed. The door top openings were closed by custom covers, and the body side coves had anodized aluminum panels fitted. The trailing end of the side coves had non-functional air scoops added. This feature was inspired by the two earlier SR-2 racing Corvettes; one built for Harley Earl's son Jerry, and one built for Bill Mitchell.

In the jelly around each egg was a substance called prostaglandin E2 (PGE2), which could turn off production of hydrochloric acid in the stomach. This source of PGE2 was enough to cease the production of acid during the embryonic stages of the developing eggs. When the eggs had hatched the tadpoles created PGE2. The mucus excreted from the tadpoles' gills contained the PGE2 necessary to keep the stomach in a non-functional state.

The Nogo-66 receptor (NgR) limits experience-driven visual cortex plasticity. In mutant mice, non-functional NgR resulted in enhancement of visual cortex plasticity after the critical period into adulthood, such that adult plasticity in the mutant mice resembled normal visual plasticity in juvenile mice brains. This function of NgR is of particular interest to the study of visual disorders that may result from imbalanced input during the critical period, such as amblyopia.

The trustworthiness of a component is thus, not surprisingly, defined by how well it secures a set of functional and non-functional properties, deriving from its architecture, construction, and environment, and evaluated as appropriate. Paulo Verissimo, Miguel Correia, Nuno F. Neves, Paulo Sousa. "Intrusion- Resilient Middleware Design and Validation". In Annals of Emerging Research in Information Assurance, Security and Privacy Services, H. Raghav Rao and Shambhu Upadhyaya (eds.), Elsevier, to appear. 2008.

LINEs use a simpler method in which the cDNA is synthesized at the target site following cleavage by a LINE- encoded endonuclease. LINE-encoded reverse transcriptase is not highly sequence-specific. The incorporation by LINE machinery of unrelated RNA transcripts gives rise to non-functional processed pseudogenes. If a small gene's promoter is included in the transcribed portion of the gene, the stable transcript can be duplicated and reinserted into the genome multiple times.

Exhaustive research of mundane items like snow shovels and bottle racks in use at the time failed to reveal identical matches. The urinal, upon close inspection, is non-functional. However, there are accounts of Walter Arensberg and Joseph Stella being with Duchamp when he purchased the original Fountain at J. L. Mott Iron Works.Shearer, Rhonda Roland: "Marcel Duchamp's Impossible Bed and Other 'Not' Readymade Objects: A Possible Route of Influence From Art To Science", 1997.

Based on these observations, they determined that Saccharomyces cerevisiae underwent a whole genome duplication soon after its evolutionary split from Kluyveromyces, a genus of ascomycetous yeasts. Over time, many of the duplicate genes were deleted and rendered non-functional. A number of chromosomal rearrangements broke the original duplicate chromosomes into the current manifestation of homologous chromosomal regions. This idea was further solidified in looking at the genome of yeast's close relative Ashbya gossypii.

The Sting Ray featured hidden headlamps, non-functional hood vents, and an independent rear suspension. Corvette chief engineer Zora Arkus-Duntov never liked the split rear window because it blocked rear vision, but Mitchell thought it to be a key part of the entire design. Maximum power for 1963 was and was raised to in 1964. Options included electronic ignition, the breakerless magnetic pulse-triggered Delcotronic first offered on some 1963 Pontiac models.

In 1985 the vinta Sarimanok was sailed from Bali to Madagascar to replicate ancient seafaring techniques. Zamboanga City also celebrates vintas in the annual Regatta de Zamboanga during the city's Zamboanga Hermosa Festival each October. The participants are usually Sama-Bajau fishermen from the coastal areas of Zamboanga. Many of these modern "vinta" however, are not vinta, but are other types of bangka (like bigiw) that merely use a vinta‑patterned sail (often non-functional).

The hind wings are much smaller than the forewings and may be vestigial or absent. The second segment of the thorax, which bears the forewings, is enlarged to hold the main flight muscles. Adults have short, flexible antennae, large compound eyes, three ocelli and non-functional mouthparts. In most species, the males' eyes are large and the front legs unusually long, for use in locating and grasping females during the mid-air mating.

Another example of a hubless vehicle is the Zero Bike, a lightweight hubless bicycle whose non-functional prototype won an Industrial Design Excellence Award in 1991."A Bicycle Far Ahead Of the Pack", New York Times, 29 August 1991 Designed by then-ArtCenter College of Design students Makota Makita and Hiroshi Tsuzaki, it is based on the principle of magnetic superconductivity, also used in high-speed trains that are suspended above rails.

Claude Debussy's Reflets dans l'eau ("Reflections in the Water") is the first of three piano pieces from his first volume of Images, which are frequently performed separately. It was written in 1905. As with much of Debussy's work, it is referred to as Impressionistic, meaning that it expresses emotions and senses by making use of non-functional harmony and ambiguous key signatures, its tonality being mainly non-diatonic and usually having a sense of modality.

Pseudodiphallia is formed from erectile tissue only, undifferentiated and non- functional. It is independent of the normal penis and can be removed surgically without problem. This rare case was reported, based on the age of the 83-year-old man when diphallia was only detected then when he was hospitalised, and also because of the absence of other anatomical malformations. The small, immature and nonfunctional penis protruded on one side of the large, normal penis.

Through different chromatin remodeling mechanisms these promoter sequences can become accessible to the RNA polymerase, and transcription becomes derepressed. Transcriptional derepression may also occur at the level of transcription factor activation. Certain families of transcription factors are non- functional on their own because their active domains are blocked by another part of the protein. Substrate binding to this second, regulatory domain causes a conformational change in the protein to allows access to the active domain.

A Davenport diesel locomotive Moïse with a 232 hp Deutz engine was salvaged from the bed of the Cherry River (Rivière Cerise).Le Train des Plantations - Bienvenue sur le site de l'association Les Rails de la Canne à Sucre. Retrieved 18 August 2018. Corpet steam locomotive A Corpet-Louvet six-wheeler steam locomotive with works No 1701 of 1925 is exhibited in a well preserved but non-functional condition at Saint James station.

In July 1832, John FitzGibbon, 2nd Earl of Clare, the then Governor of Bombay, laid the foundation stone and the building was ready by August 1833. Though the first service was held on 10 August, 1833, the church was only consecrated two years later in December 1935 by Revd. Daniel Wilson, the then Bishop of Calcutta. The church is home to one of the city's few pipe organs, but like most of them it is non-functional.

The bromodomain is found in proteins that regulate transcription. Two transcript variants encoding the same protein have been found for this gene. The use of three different mouse models (Brdt knock-out mice, mice expressing a non-functional Brdt and mice expressing a mutated Brdt lacking its first bromodomain) showed that Brdt drives a meiotic and post-meiotic gene expression program. It also controls the genome-wide post-meiotic genome reorganization that occurs after histone hyperacetylation in elongating spermatids.

Coronary anastomoses are anatomically present though functionally obsolete. There was some suggestion that they may be helpful if a problem develops slowly over time (this will need to be verified) but in the case of the pathogenesis of CHD they do not provide a sufficient blood flow to prevent infarction. There are anastomoses between the Circumflex and right coronary arteries and between the anterior and posterior inter-ventricular arteries. In the normal heart these anastomoses are non-functional.

The music is largely modal, beginning with pentatonic (both major and minor) scales. (English version adapted by Margaret Murray) The drone or bordun, is quickly established as the ground bass that supports most melodies and melodic ostinati add energy and colour. Volume II in Part One, covers hexachordal (added fa) melodies over Major Drone Bass Triads, and then seven notes: Ionian mode. Note, this is not major scale, as the drone bass enforces a non-functional harmony.

Because in the adult holotype specimen well-preserved mouthparts (palps) are visible, the adult animals almost certainly were able to feed. In direct contrast, the adult form of modern mayflies has dramatically reduced, non-functional mouthparts, and lives solely to reproduce. The raptorial forelegs and oblique thorax indicate that Mickoleitia was a predator. The large and broad hinds suggest that they were ecologically similar to dragonflies, in that they were swift, flying predators of other flying insects.

Sometimes it is useful to consider a constant to be an operation of arity 0, and hence call it nullary. Also, in non-functional programming, a function without arguments can be meaningful and not necessarily constant (due to side effects). Often, such functions have in fact some hidden input which might be global variables, including the whole state of the system (time, free memory, …). The latter are important examples which usually also exist in "purely" functional programming languages.

This autosomal recessive disorder results in a totally non-functional insulin receptor. These patients have low-set, often protuberant, ears, flared nostrils, thickened lips, and severe growth retardation. In most cases, the outlook for these patients is extremely poor, with death occurring within the first year of life. Other mutations of the same gene cause the less severe Rabson-Mendenhall syndrome, in which patients have characteristically abnormal teeth, hypertrophic gingiva (gums), and enlargement of the pineal gland.

Mingo County is West Virginia's newest county, formed by an act of the state legislature in 1895 from parts of Logan County. The county was named for the Mingo Indians. At the time of its creation, Mingo County was divided into magisterial districts, which the United States Census Bureau classifies as a type of non-functional subdivision serving purely administrative purposes.United States Census Bureau, U.S. Decennial Census, Tables of Minor Civil Divisions in West Virginia, 1870–2010.

The first item is a royal present that contains an object that the Prince can wear. Most gifts are non-functional, but one includes a camera that can be used to take in-game screenshots. The other secret item is a cousin of the Prince, which, once rolled up in main gameplay, can be used as a character in the various multiplayer modes. However, cousins can only be found and rolled up after the game is beaten.

In the Winter 2016 double issue, Kiki announced that all Kiki subscribers would get an issue of New Moon Girls along with a free membership to the New Moon Girls online community. Kiki's website announced in early 2016 that the Winter 2016 double issue would be the final issue of Kiki to be released. By April the website was rendered non-functional, and had ceased to be offered for subscription through Amazon. Kiki officially had folded.

By early 1994, the Famous-Barr store was found to be in a state of disrepair, with portions of the store partitioned off and non-functional bathrooms. Famous-Barr finally closed their store there in June 1994. Following the closure of Famous-Barr, the center grew increasingly vacant, and was purchased by Sansone Group in late 2000 for redevelopment. Demolition of the structures finally occurred in 2005 with the last business at the site closing in June.

Durham Tees Valley Airport Terminal Building There is no railway station in Longnewton, however there are several stations nearby which are accessible by car, or possibly bus. The nearest station is Teesside Airport railway station although this is effectively non-functional as only two trains stop there a week, however, there are others nearby including those of , and . Darlington station is a more mainline station, however this is a 15-minute journey from Longnewton with no direct bus routes.

The studio was very much a museum when they arrived—they found vintage recording gear that no longer operated, along with photos on the walls of legendary performers, such as Lynyrd Skynyrd, who had once recorded there. Auerbach immediately took down the photos, feeling they were distracting decorations. The band put a piece of Plexiglas on top of the studio's non- functional console to hold their own digital recording equipment. The group experienced technical difficulties while recording.

Moel y Gaer hillfort is surrounded by steep slopes to the north, west, and south. To the east the approach is almost level and is where the main entrance is sited. There is also a non-functional entrance to the west. Most of the fort is surrounded by a double bank and ditch, with additional banks to the northeast, near the entrance, across the ridge connecting the hill to the higher ground leading to Moel Famau.

The latter research study was intended to pave the way for potential human use if successful. However, xenotransplantion is often an extremely dangerous type of transplant because of the increased risk of non-functional compatibility, rejection, and disease carried in the tissue. In an opposite twist, Ganogen Research Institute CEO Eugene Gu is studying how to transplant human fetal hearts and kidneys into animals for future transplantation into human patients to address the shortage of donor organs.

Choosing a hairstyle. Certain choices, as personal preferences, can be central to expressing one's concept of self-identity or values. In general, the more utilitarian an item, the less the choice says about a person's self-concept. Purely functional items, such as a fire extinguisher, may be chosen solely for function alone, but non-functional items, such as music, clothing fashions, or home decorations, may instead be chosen to express a person's concept of self- identity or associated values.

This style dominated British studio pottery in the mid-20th-century. The Austrian refugee Lucie Rie (1902–1995) has been regarded as essentially a modernist who experimented with new glaze effects on often brightly coloured bowls and bottles. Hans Coper (1920–1981) produced non-functional, sculptural and unglazed pieces. After the Second World War, studio pottery in Britain was encouraged by the wartime ban on decorating manufactured pottery and the modernist spirit of the Festival of Britain.

Limited proteolysis of a polypeptide during or after translation in protein synthesis often occurs for many proteins. This may involve removal of the N-terminal methionine, signal peptide, and/or the conversion of an inactive or non-functional protein to an active one. The precursor to the final functional form of protein is termed proprotein, and these proproteins may be first synthesized as preproprotein. For example, albumin is first synthesized as preproalbumin and contains an uncleaved signal peptide.

With provinces non-functional in practice, Taiwan is divided into 22 subnational divisions each with a local government led by an elected head and a local council. Matters for which local governments are responsible or partially responsible include social services, education, urban planning, public construction, water management, environmental protection, transport and public safety. There are three types of subnational divisions: special municipalities, cities and counties. Special municipalities and cities are further divided into districts for local administration.

The increased size also increased the car's weight by . Along with a new, more rigid unibody construction was new styling, including quad headlights, more prominent tailfins, a bolder chrome grille, and a larger, though non-functional, hood scoop. Powering the Thunderbird was a new, FE V8, available with a three-speed manual or automatic transmissions. In the 1958 model year in which the car was introduced, sales were 37,892 units, outselling the previous model year's 16,000 units.

It is important to note that conserving a non-functional clock is much less invasive (cheaper!) and preventive protection against corrosion and environmental hazards is the main concern for its stabilization and care.[viii] Perhaps the least invasive solution to highlight a functional clock would be to purchase a replica clock and safely store the original”. Running clocks also require winding, which adds to the wear-and-tear of the gears and leads to more handling of the object.

Plastid DNA of maize seedlings is subject to increased damage as the seedlings develop. The DNA is damaged in oxidative environments created by photo- oxidative reactions and photosynthetic/respiratory electron transfer. Some DNA molecules are repaired while DNA with unrepaired damage appears to be degraded to non-functional fragments. DNA repair proteins are encoded by the cell's nuclear genome but can be translocated to plastids where they maintain genome stability/integrity by repairing the plastid's DNA.

The Donor Sibling Registry is based solely on user input, and does not use scientific input to prove its matching capability, which is problematic when determining genetic relationships. The current model used by DSR leaves users open to matching errors that could be compounded by incorrect data or false data from clinics. In those cases where donor information is limited or unknown, the DSR matching capability is at best a guess or in most cases non-functional.

In the Agathiphagidae, larvae live inside kauri pines and feed on seeds. In Heterobathmiidae the larvae feed on the leaves of Nothofagus, the southern beech tree. These families also have mandibles in the pupal stage, which help the pupa emerge from the seed or cocoon after metamorphosis. The Eriocraniidae have a short coiled proboscis in the adult stage, and though they retain their pupal mandibles with which they escaped the cocoon, their mandibles are non- functional thereafter.

However, the flight data recorder shows that the flight did not descend, but was instead rising and falling uncontrollably. Hydraulic fluid completely drained away through the rupture. With the total loss of hydraulic control and non-functional control surfaces, the aircraft began up and down oscillations in phugoid cycles lasting about 90 seconds each. The loss of the vertical stabilizer and the rudder removed the only means to dampen yaw, and the aircraft lost virtually all meaningful yaw stability.

Because ribosomes are so complex, a certain number of ribosomes are assembled incorrectly and could potentially waste cellular energy and resources when synthesizing non-functional proteins. To prevent this, cells have an active surveillance system to recognize damaged or defective ribosomes and target them for degradation. The surveillance mechanism is in place to detect nonfunctional pre-ribosomes as well as nonfunctional mature ribosomes. In addition, the surveillance system brings the necessary degradation equipment and actually degrades the nonfunctional ribosomes.

The ISVV team independency is performed at three different levels: financial, managerial and technical. ISVV goes far beyond “traditional” verification and validation techniques, applied by development teams. While the latter aim to ensure that the software performs well against the nominal requirements, ISVV is focused on non-functional requirements such as robustness and reliability, and on conditions that can lead the software to fail. ISVV results and findings are fed back to the development teams for correction and improvement.

Achham is one of the remotest districts of Nepal. It is accessible by automobile from Kathmandu and Nepalgunj via a paved road that runs along the western border of Nepal from Dhangadhi. The unpaved of Mid-Hill Highway through Dailakh district also takes to Mangalsen by crossing Karnali at Rakam. Mangalsen, the district headquarters, is eight hours walk and two and one-half hour drive from Sanphebagar – a town in Achham sporting a non- functional domestic airport.

Two weeks of troubleshooting resulted in the unit starting up again, then immediately shutting down. The cause was eventually traced to gas bubbles in the unit, which remained non-functional until a Progress resupply mission in October 2004. In 2005 ISS personnel tapped into the oxygen supply of the recently arrived Progress resupply ship, when the Elektron unit failed. In 2006 fumes from a malfunctioning Elektron unit prompted NASA flight engineers to declare a "spacecraft emergency".

Surface features also include the remnants of a helicopter pad and a theodolite siting marker, and the original access road to the facility from US 65. The facility was staffed by the 374th Strategic Missile Squadron between 1963 and 1986, housing an LGM-25C Titan II ICBM, and was decommissioned and rendered non-functional in 1987 under the terms of the SALT II strategic arms treaty. The site was listed on the National Register of Historic Places in 2000.

The influence of Sec14p in the localization of lipid rafts is inferred due to abnormal localization and transport of lipid raft localized proteins in mutant yeast strains with non-functional Sec14p. Upon restoration of Sec14p function in these mutant strains, the wayward lipid raft proteins localized to their wild-type location. Experimental evidence suggests Sec14p may play a role in sorting proteins for incorporation into lipid rafts at the Golgi body prior to transport to the plasma membrane.

The stock A4000 shipped with either a Motorola 68EC030 or 68040 CPU, 2 MB of Amiga Chip RAM and up to 16 MB of additional RAM in 32-bit SIMMs. There is a non-functional jumper that was intended to expand the "chip RAM" to 8MB. Later, third-party developers created various CPU expansion boards featuring higher-rated 68040, 68060 and PowerPC CPUs. Such hardware also typically offers faster and higher-capacity RAM (128 MB or greater).

Subjective meant free, personal, non-functional practice. The radical artist Chargesheimer (pseudonym of Karl-Heinz Hargesheimer) having studied graphics and photography at the Cologne Werkschulen (1942–43) and at the Bavarian State Institute for Photography in Munich (1943–44), and pursuing his interest in theatre from 1947 as a freelance photographer for various playhouses in Germany, encountered fotoform and in 1950 participated in their “photo-kino” exhibition in Cologne and also in their legendary exhibitions of “subjektive fotografie” in 1952 and 1954.

Based on phylogenetic analysis of the internal transcribed spacer region in the non- functional RNA of a number of Suillus species, S. quiescens is distinct from other morphologically similar species such as S. brevipes, S. volcanalis, and S. occidentalis. The S. quiescens sequences, which were obtained from fruit bodies and from mycorrhizal root tips, formed a clade. The analysis showed that the S. quiescens sequences were matches to some unidentified Suillus sequences found from mycorrhizae of pine seedlings collected from Oregon and California.

It has 66 windows, two working chimneys and two interior non- functional chimneys. Inside the house, is an oak staircase stretching three floors, 43 doors and extensive wood decoration have retained their original finish with few minor changes over the years. Throughout its history, the home was occupied by the Gauff family in 1880, the Roths in 1930, and the Ziegler's in 1982. At one Sunday dinner, Wilbur Roth discovered the hobo at his table was the brother of a prominent Allentonian.

During World War I, Allied forces made use of dummy versions of the British heavy tanks. These were constructed from a wooden framework and covered with painted Hessian cloth. The tracks were non-functional so some were fitted with concealed wheels underneath and were towed from place to place by a pair of horses. Dummy tanks, representing Allied models, were also found to have been constructed by the Germans, even though they deployed only a small number of real tanks.

Paul heads off to an electronics recycling depot to raid what they have. One old monitor and overhead projector later, and a "poor man's projection display" is completed. An all-nighter by the entire crew later, Paul continues his work on the door opener, still non-functional after 18 days. Geoff, however, doesn't have the money to dispose of the leftover garbage from their build (needing $500 for a garbage bin), and Geoff is pressuring Andy to sell the bike chair once again.

A dam, dating from 1240 BC, was announced to be reopened for use on September 23, 2006. The dam was ordered by King Tudhaliya IV in the name of the goddess Hebat. According to ancient Hittite tablets, a drought struck Anatolia in 1200 BC, prompting the King to import wheat from Egypt so that his land would avoid famine. Following this, the king ordered numerous dams to be built in central Anatolia, all but one of them becoming non-functional over time.

Transposable genetic elements, DNA sequences that can replicate and insert copies of themselves at other locations within a host genome, are an abundant component in the human genome. The most abundant transposon lineage, Alu, has about 50,000 active copies, and can be inserted into intragenic and intergenic regions. One other lineage, LINE-1, has about 100 active copies per genome (the number varies between people). Together with non-functional relics of old transposons, they account for over half of total human DNA.

Cholesterol sulfate, or cholest-5-en-3β-ol sulfate, is an endogenous steroid and the C3β sulfate ester of cholesterol. It is formed from cholesterol by steroid sulfotransferases (SSTs) such as SULT2B1b (also known as cholesterol sulfotransferase) and is converted back into cholesterol by steroid sulfatase (STS). Accumulation of cholesterol sulfate in the skin is implicated in the pathophysiology of X-linked ichthyosis, a congenital disorder in which STS is non-functional and the body cannot convert cholesterol sulfate back into cholesterol.

WFFS is a genetic defect of connective tissue and foals born with it have hyper-extendible, abnormally thin, fragile skin that rips easily (similar to epidermolysis bullosa in humans). It is associated with mutations in the gene coding for Lysyl hydroxylase 1 that result in a non functional enzyme. A genetic test for Warmblood Fragile Foal Syndrome Type 1 was made commercially available in 2013. Approximately 9–11% of Warmblood horses are carriers, and a lower carrier frequency in Thoroughbreds and Knabstruppers.

A culture of such bacteria, which are diploid for the lac genes but otherwise normal, is then tested for the regulatory phenotype. In particular, it is determined whether LacZ and LacY are made even in the absence of IPTG (due to the lactose repressor produced by the mutant gene being non-functional). This experiment, in which genes or gene clusters are tested pairwise, is called a complementation test. 500px This test is illustrated in the figure (lacA is omitted for simplicity).

He and Vicky drive off in search of aid, not realizing they are being watched by Isaac (Preston Bailey), the 9-year old current cult leader, and 18-year-old warrior Malachai (Daniel Newman). After hearing a group of children giving an evangelical sermon over the radio, Burt and Vicky reach an abandoned gas station. Finding the phones non-functional Burt decides to go to Gatlin. While Burt drives, Vicky finds an amulet which she recognizes as a pagan creation.

The ARCADIA method applies to the design of complex and critical systems, and more generally architectures that are subject to multiple functional and non-functional constraints, including software, electronic, electrical architectures, and industrial processes. It defines a set of practices that guides needs analysis and design to meet an operational requirement. At the same time it is adaptable to the processes and constraints linked to various types of life cycles such as bottom-up approach, application reuse, incremental, iterative and partial development.

Besides limiting elastase activity to limit tissue degradation, A1PI also acts to induce locomotion of lymphocytes through tissue including immature T cells through the thymus where immature T cells mature to become immunocompetent T cells that are released into tissue to elevate immune responsiveness. Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations in these areas can lead to non- functional proteins that can polymerise and accumulate in the liver (infantile hepatic cirrhosis).

The SBDS gene resides in a block of genomic sequence that is locally duplicated on the chromosome. The second copy contains a non-functional version of the SBDS gene that is 97% identical to the original gene, but has accumulated inactivating mutations over time. It is considered to be a pseudogene. In a study of 158 SDS families, 75% of disease- associated mutations appeared to be the result of gene conversion, while 89% of patients harbored at least one such mutation.

Kenshin has also been featured various times in the Animages Anime Grand Prix polls, ranking as one of the most popular male anime characters. In a Newtype poll in March 2010, Kenshin was voted the eighth most popular male anime character from the 1990s. An abundance of merchandise have been released in Kenshin's likeness including keychains, action figures, and plush dolls. Since the manga was published, non-functional and functional sakabatō have been produced for purchase by collectors and fans.

Once designed, a TALEN is introduced into a cell as a plasmid or mRNA. The TALEN is expressed, localizes to its target sequence, and cleaves a specific site. After cleavage of the target DNA sequence by the TALEN, the cell uses non-homologous end joining as a DNA repair mechanism to correct the cleavage. The cell's attempt at repairing the cleaved sequence can render the encoded protein non-functional, as this repair mechanism introduces insertion or deletion errors at the repaired site.

A few models of single-shot .22 calibre free pistol, as used in the 50 m Olympic 'Free Pistol' match, have been produced to meet the "long-barrelled pistol" conditions. Some free pistols have removable stabiliser bars extending backwards to improve stability; the UK-legal models have been made with non- removable stabilisers to extend the dimensions, instead of contrived and non- functional grip extensions. Examples are the single-shot Pardini K22 Longarm and the Westlake Britarms Long Pistol, a permitted .

Vaikom-Ettumanoor Road which traverses Vallakam is the life-line linking the village with prominent markets like Thalayolaparambu and Kuruppanthara to the East and the municipal town of Vaikom to the West. The village's system of canals too were important in transportation till recent times. These are non-functional now because of large scale 'filling' of them for housing and other purposes and due to the spread of the fresh water weed called in Malayalam 'African payal' (Salvinia molesta) which chokes inland waterways.

Orozco, Silvino.S3 Savage 2000 Preview, Tom's Hardware, November 2, 1999. However, S3TL shipped completely non-functional, primarily because initial drivers were Direct3D 6-based (Direct3D 7 was the first release with HW T&L; support). Savage 2000 was an AGP 2X/4X card and had an internal 350 MHz RAMDAC. The Diamond Viper II Z200 had 32 MB SDR SDRAM. The initial pre-release specifications had called for a 175 MHz core clock rate, with a resulting 700 million texels/second fillrate.

Claire Zeisler (April 18, 1903 – September 30, 1991) was an American fiber artist who expanded the expressive qualities of knotted and braided threads, pioneering large-scale freestanding sculptures in this medium. Throughout her career Zeisler sought to create "large, strong, single images" with fiber. Zeisler's non-functional structures were constructed using traditional weaving and avant-garde off the loom techniques such as square knotting, wrapping, and stitching. Zeisler preferred to work with natural materials such as jute, sisal, raffia, hemp, wool, and leather.

The non-functional gulonolactone oxidase pseudogene (GULOP) was mapped to human chromosome 8p21 that corresponds to an evolutionarily conserved segment on either porcine chromosome 4 (SSC4) or 14 (SSC14).GULOP – iHOP GULO produces the precursor to ascorbic acid, which spontaneously converts to the vitamin ("vitamin C"). The loss of activity of the gene for L-gulonolactone oxidase (GULO) has occurred separately in the history of several species. GULO activity has been lost in some species of bats, but others retain it.

Kestrel engine glows red-hot during Falcon 1's fourth launch and first successful orbital flight. The fourth flight of the Falcon 1 rocket successfully flew on 28 September 2008, delivering a 165-kilogram (363-pound) non-functional boilerplate spacecraft into low Earth orbit. It was Falcon 1's first successful launch and the first successful orbital launch of any privately funded and developed, liquid-propelled carrier rocket. The launch occurred from Omelek Island, part of the Kwajalein Atoll in the Marshall Islands.

Sometimes, the resurrected pseudogenes have been identified as functional and they may also be altered back to be non-functional, which again can be reversed. Not all the pseudogenes in a genome should be considered as a “junk DNA”. The evidence for functional pseudogenes strengthens their significance, and they have also become a hotspot in research due to their significance and possible resurrection. To study the characteristics of this soundless fossil in human and other organisms, researchers are contributing their attempts.

Alu elements contain four or fewer retinoic acid response element hexamer sites in its internal promoter, with the last one overlapping with the "B box". In this 7SL (SRP) RNA example below, functional hexamers are underlined using a solid line, with the non-functional third hexamer denoted using a dotted line: . The recognition sequence of the Alu I endonuclease is 5' ag/ct 3'; that is, the enzyme cuts the DNA segment between the guanine and cytosine residues (in lowercase above).

It has similar finishes, and a non-functional freight lift on the east wall. Also on the east wall, a five-panel door opens into the closed stair along the east wall. A small storage room in the northwest corner is accessed from this space, divided from the main hall by a partially glazed wall on the south. The stair itself, located behind another paneled door at the north end of the entrance hall, is lit by the windows on that elevation.

One major feature of Thylacoleo is its dentition. "It had no canines in the lower jaw, only small, non-functional canines in the upper jaw." One possible reason for its carnivorous diet was the lack of any grinding teeth precluded the inclusion of any plant matter. According to the place where the fossils were discovered, the habitat would have appeared as dry, open areas with forest and woodland. “Kangaroos (aka macropods) belong to a large, mostly herbivorous Australasian marsupial clade termed Diprotodontia.

Other special features include automatic headlamp controls with twilight sensor, cornering lamps, bilevel automatic airconditioning, Superlift air adjustable shockabsorbers, Safe-T-Track limited slip differential, an electric sunroof, cruise control, central locking, a burglar alarm, non- functional exhaust side pipes, and a high-end Lear Jet AM/FM eight-track quadraphonic sound system. The first models rolled on special 17-inch Firestone LXX run-flat tires and rims. These were taken off the market however as they turned out to be unsafe.

In humans there are 102 putative DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases, consisting of 58 ubiquitin-specific proteases (USPs), 4 ubiquitin C-terminal hydrolases (UCHs), 5 Machado-Josephin domain proteases (MJDs), 14 ovarian tumour proteases (OTU), and 14 Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain-containing genes. 11 of these proteins are predicted to be non- functional, leaving 79 functional enzymes. In yeast, the USPs are known as ubiquitin-specific-processing proteases (UBPs).

Functional and non-functional testing of Web services is done with the help of WSDL parsing. Regression testing is performed by identifying the changes made to upgrade software. Web service regression testing needs can be categorized in three different ways, namely, changes in WSDL, changes in the code, and selective re-testing of operations. We can capture the above three needs in three intermediate forms of Subset WSDL, namely, Difference WSDL (DWSDL), Unit WSDL (UWSDL), and Reduced WSDL (RWSDL), respectively.

Often the character of the pain is the differentiator between dental and non-dental pain. Irreversible pulpitis progresses to pulp necrosis, wherein the nerves are non-functional, and a pain-free period following the severe pain of irreversible pulpitis may be experienced. However, it is common for irreversible pulpitis to progress to apical periodontitis, including an acute apical abscess, without treatment. As irreversible pulpitis generates an apical abscess, the character of the toothache may simply change without any pain-free period.

Therefore, mice carrying a non-functional Mx allele fail to synthesise the Mx protein and are more susceptible to influenza infection. Alternatively, immunocompromised individuals due to existing illnesses may have a defective immune system which makes them more vulnerable to damage by the virus. Furthermore, a number of viruses display variable pathogenicity depending on the age of the host. Mumps, polio, and Epstein-Barr virus cause more severe disease in adults, while others like rotavirus cause more severe infection in infants.

Just after this, the hand guard on the forte of the blade lay a feature typically of copper or iron called tunkou in China. This was made as a sleeve of metal to wrap around the blade, designed to aid the sword sealing into the scabbard. Some early tunkou of high status swords were gilded and decorated with patterns. Later swords that descended from these blades bore non functional tunkou that were ornamental and at times just etched onto the blades.

Destructive testing attempts to cause the software or a sub-system to fail. It verifies that the software functions properly even when it receives invalid or unexpected inputs, thereby establishing the robustness of input validation and error-management routines. Software fault injection, in the form of fuzzing, is an example of failure testing. Various commercial non-functional testing tools are linked from the software fault injection page; there are also numerous open-source and free software tools available that perform destructive testing.

The related load testing activity of when performed as a non-functional activity is often referred to as endurance testing. Volume testing is a way to test software functions even when certain components (for example a file or database) increase radically in size. Stress testing is a way to test reliability under unexpected or rare workloads. Stability testing (often referred to as load or endurance testing) checks to see if the software can continuously function well in or above an acceptable period.

Because of the presence of darts in many superfamilies of the Stylommatophora, it seems likely that love darts appeared during the early evolution of the Pulmonata, and that the ancestors of the Stylommatophora possessed darts already. During evolution, darts appear to have been lost secondarily, i.e., after they had evolved and been functional. Vestigial darts (ones that exist only in a rudimentary condition) occur in the family Sagdidae, and in many Helicoidea, the surrounding organs have also degenerated (become non- functional).

Jack Streat has produced a number of rubber band guns, including a replica Lee–Enfield bolt- action sniper rifle. He has produced a book, LEGO Heavy Weapons (No Starch Press). The SF Gate expressed concern that the book could encourage children into aggression and gun-love. Will Chapman has circumvented Lego's opposition to modern weaponry by casting his own non-functional lego guns: he constructed aluminum molds from a CNC mill and injection-molded plastic from melted-down Lego bricks.

Nafarelin is a GnRH agonist, or an agonist of the GnRH receptor, the biological target of GnRH. It works by continuously activating the GnRH receptor, which results in profound desensitization of the receptor such that it becomes non-functional. As a result, nafarelin suppresses the GnRH-induced secretion of the gonadotropins, luteinizing hormone and follicle-stimulating hormone, from the pituitary gland. This, in turn, results in profound suppression of gonadal sex hormone production, as well as reversible suppression of fertility.

The majority of structures built at West Stow belonged to a category of what the excavators called "sunken-featured buildings", a term first coined by Professor Philip Rahtz. In previous decades, buildings in this style had been known as "pit houses", "sunken houses" or "grubenhauser" (), but site director Stanley West noted that Rahtz's terminology had been adopted because it was "less contentious" and provided "a non-functional description." Seventy such sunken-featured buildings, or SFBs, were recorded at the site.

It was initially based on the AT&T; NCR 9800 series mainframe architecture - creating a UNIX and an NT/Windows Server branch. The COBOL source code was interchangeable, but software interfacing with the OS, such as transaction queues, differed in order to handle the various implementations written in C and linked into the Microfocus COBOL runtime system-linked object. Scripting varied across branches to handle operations and non- functional requirements. Major versions featured multi-currency (with spot positions) and multi-language functionality.

The term also applies to those incapable, mentally or physically, to perform certain acts in consideration with the position of financial level. Lack of capacity: financial, physical, as well as mental can be considered with verification, Medically Indigent. In the United States this term is applied regardless of race, religion, creed, or ethnicity, an actual state of being, very close to a disability, yet on the border of seemingly or likely to be non-functional at the time of decision making.

104:20421–20426 Within the mammalian phylogenetic tree, a large number of gene gains and losses are observed for almost all branches, suggesting that a significant fraction of gene number changes were caused by inactivation events and random gene duplication. This process is known as genomic drift, or “random genetic drift of gene frequencies” in population genetics. Pseudogenes are also subject to genomic drift, since they are rendered as non-functional and are believed to evolve in a neutral manner.Li, W. H., Gojobori, T., & Nei, M. (1981).

French-US relations were strained at this time due to de Gaulle's policy of "Politics of Grandeur", and in return, de Gaulle was highly skeptical of the US's motives. Believing the story to be a fabrication, French intelligence was very deliberate in their investigations, and no action had been taken by late 1962. This was to the amazement of the US establishment, who began to take measures to exclude France from the NATO reporting chain. This led to NATO becoming largely non-functional for a year.

Like most burrowing mammals with similar habits, the Chrysochloridae have short legs with powerful digging claws, very dense fur that repels dirt and moisture, and toughened skin, particularly on the head. Their eyes are non-functional and covered with furred skin. The external ears are just tiny openings. In particular, golden moles bear a remarkable resemblance to the marsupial moles of Australia, family Notoryctidae, which they resemble so suggestively that at one time, the marsupial/placental divide not withstanding, some argued that they were related.

The wings of the queens are rudimentary and stubby, barely overlapping the first gastral segment, and are brachypterous (non-functional). Males resemble those of Myrmecia, but Nothomyrmecia males bear a single waist node. The wings on the male ant are not stubby like a queen's; rather they are long and fully developed, exhibiting a primitive venational complement. They have a jugal anal lobe (a portion of the hindwing), a feature found in many primitive ants, and basal hamuli (hook-like projections that link the forewings and hindwings).

The Burlingiidae constitute a family of trilobites of uncertain affinity, that lived during the Middle to lowest Upper Cambrian (Acadoparadoxides pinus- to Agnostus pisiformis-zone). Burlingiids have a cosmopolitan distribution, can be found in deposits that originate from outside the continental shelves, and may have been planktonic. They are characterized by their oval shape, small size (less than ), proparian sutures, and non-functional articulations of the thorax. Uniquely the anterior borders of the pleura are raised, and there are between 8 and 15 thorax segments.

Iraqi T-54/T-55 on the Highway of Death in 1991. The rear of the tank has been blown away, making it irreparable. A catastrophic kill, K-Kill or complete kill is damage inflicted on an armored vehicle that amounts to complete destruction of the vehicle, rendering it both permanently non-functional and irreparable. The term knocked out refers to a vehicle which has been damaged to the point of inoperability and abandoned by its crew, but is not obviously beyond the point of repair.

Noncoding RNA molecules play many essential roles in cells, especially in the many reactions of protein synthesis and RNA processing. Noncoding RNA include tRNA, ribosomal RNA, microRNA, snRNA and other non-coding RNA genes including about 60,000 long non-coding RNAs (lncRNAs). Although the number of reported lncRNA genes continues to rise and the exact number in the human genome is yet to be defined, many of them are argued to be non-functional. Many ncRNAs are critical elements in gene regulation and expression.

Pagefast Ltd, Lancaster UK, 2003. ISSN 1368-485X After ceasing production of aircraft, the company carried on as a supplier of security and surveillance equipment. The company seems to have been founded about 2002, but by 2015 the company website was non-functional and so it is not clear if the company is still in business or not. The company designed and produced its own paramotor engine, the Arey A-170 and then designed a paramotor to use the engine, the Arey Tatush T120M.

In a small proportion of familial amyotrophic lateral sclerosis (fALS), the UBQLN2 gene is mutated, causing formation of a non-functional Ubiquilin 2 enzyme. This non-functioning enzyme leads to the accumulation of ubiquinated proteins in the lower motor neurons and upper corticospinal motor neurons, due to the fact that ubiquilin 2 normally degrades these ubiquinated proteins, but cannot if the ALS mutation is present. The same accumulations occur in patients without UBQLN2 mutations, but with mutations in other genes, including TDP-43 and C9ORF72.

On one view, biological or language-specific mechanisms become non-functional after a certain age. On another view, decreased L2 learning ability with age is not inevitable, and can be explained by factors such as motivation, learning environment, pressure, and time commitment. Although there is evidence that supports the claim that speakers outside the L2 mastery age range are not capable of acquiring native-like mastery of a language, there is also evidence supporting the opposite, as well as evidence for young learners not mastering an L2.

Software-defined infrastructure (SDI) is the definition of technical computing infrastructure entirely under the control of software with no operator or human intervention. It operates independent of any hardware-specific dependencies and is programmatically extensible. In the SDI approach, an application's infrastructure requirements are defined declaratively (both functional and non-functional requirements) such that sufficient and appropriate hardware can be automatically derived and provisioned to deliver those requirements. Typical deployments require software-defined networking (SDN) and cloud computing capabilities as a minimal point of entry.

Also, STAT4 mutations have been associated with rheumatoid arthritis, and STAT6 mutations are linked to asthma. Patients with a faulty JAK-STAT signalling pathway may also experience skin disorders. For example, non-functional cytokine receptors, and overexpression of STAT3 have both been associated with psoriasis (an autoimmune disease associated with red, flaky skin). STAT3 plays an important role in psoriasis, as STAT3 can control the production of IL-23 receptors, and IL-23 can help the development of Th17 cells, and Th17 cells can induce psoriasis.

On 4 May 2015, evidence of a Yemeni Il-76TD at Sana'a International Airport engulfed in flames emerged. The fate of the Yemeni MiG-29 fleet remains unknown while the assessment on the number of other air-frames destroyed is difficult to establish. As of 2017 the Yemeni Air force after years of warfare and the Saudi-led coalition bombing is inoperable and non-functional. After government troops recaptured the Al Anad Air Base, the Yemeni air force was rebuilt and was trained by the UAE.

Hnahthial district is one of the eleven districts of Mizoram state in India. The creation of Hnahthial District was first notified on 12th September, 2008 but until 2020, it remained non-functional despite a number of promises made by top political leaders and an all-out effort by Hnahthial District Function Demand Committee to let the state government make it functional. Hnahthial district was made functional only 12 years later on 3rd June, 2019 with the creation of the office of the Deputy Commissioner..

Pseudogenes, also known as noncoding DNA, are extra DNA in a genome that do not get transcribed into RNA to synthesize proteins. Some of this noncoding DNA has known functions, but much of it has no known function and is called "Junk DNA". This is an example of a vestige since replicating these genes uses energy, making it a waste in many cases. A pseudogene can be produced when a coding gene accumulates mutations that prevent it from being transcribed, making it non-functional.

On the very top of her head are her cat ears, which are white with pink inside and have a set of large, non-functional lime-coloured cat eyes. She always wears white gloves and boots (with the exception of her sleeping outfit) and she has a white tail. She is consistently seen in this costume in her various series with the exception of Panyo Panyo Di Gi Charat where she wears a different costume in her super deformed character design in that series.

The implication of these up gradations are many: the immediate effect was that scores of IPS officers not withstanding their responsibilities were immediately made senior in pay grade, and status to Armed forces formation and fleet commanders, who were denied proportionate upgrades despite representation by the COSC committee; mass up-gradation and creation of new posts of secretaries and special secretaries, and DGs with apex grade pay level, also affected relative pensions. 'Non-functional financial up- gradation'(NFU) was not extended to Armed Forces.

Nothing had been agreed to so far. Referring to questions raised on the financial implication of OROP he said that when the government sanctioned Non Functional Upgrades to the All India Services after the 6th Pay Commission no question on the financial implications were raised. Shekhar Gupta, calling ex servicemen protest unedifying spectacle on a popular English language TV news channel, argued that ex-servicemen should accept what is offered. 5 September 2015 Government unilaterally announces the implementation the 'OROP Scheme' for the Armed Forces.

The replacement rest area was designed to mimic an early 1900s era train depot to honor the town, including a replica roundhouse and non-functional steam locomotive built by Original Creations of Carbonville, Utah. The buildings were designed by the Archiplex Group of Salt Lake City. The rest area was voted one of the most beautiful buildings in the state of Utah in a contest sponsored by the American Institute of Architects. It is also one of the busiest non-freeway rest areas in the state.

The village has a rich deposit of limestone and there used to be a cement factory, which now is non- functional. Hungpung is famous for the yearly pre-harvest festival celebration, locally known as Dharreo wherein the neighboring villages and tourists participate in large number. The village is one of the 44 villages in Ukhrul district that would be affected being a catchment area when the Mapithel Dam is finally completed. The sitting MLA from 44 Ukhrul (ST) Assembly Constituency, Samuel Risom hails from Hungpung village.

Supreme Judicial Council (SJC) has adjourned the hearing of presidential reference against non-functional Chief Justice Iftikhar Muhammad Chaudhry till 18 April. The SJC had decided that from now onwards, the hearing would be carried out on two consecutive days. The lawyer of Justice Iftikhar Chaudhry Barrister Atizaz Ahsan argued about the position of three SJC judges Justice Javed Iqbal, Justice Chaudhry Iftikhar and Justice Abdul Hamid Dogar. In a three-hour session, Atizaz Ahsan completed his legal arguments on the objections and reservations regarding judges' position.

A&E; is a pay-TV channel of A&E; Networks, headquartered in Munich. A&E; stands for Arts and Entertainment, which has been the title of A&E; Network in America for many years. The channel broadcasts its full program in Germany, Austria and Switzerland. A&E; is a registered trademark of The History Channel (Germany) GmbH & Co. KG. In the German-speaking world, the non-functional digital transmitter is operated in a joint venture between NBC Universal Global Networks Deutschland GmbH and A+E Networks.

Sidewalk valve for long defunct gas lighting company, Uptown New Orleans. Since most items of street furniture are of a utilitarian nature, authorities generally keep them up-to-date and replace them regularly (usually to conform to regulations, safety codes, etc.). Because of this, old, outdated, obsolete, or even non- functional street furniture can be rare sights and hold a special fascination and inspire nostalgia for many people. The Tiergarten park in Berlin has a collection of antique streetlamps from around the world, both gas and electric.

Nonetheless, bacterial expression has the advantage of easily producing large amounts of protein, which is required for X-ray crystallography or nuclear magnetic resonance experiments for structure determination. Because bacteria are prokaryotes, they are not equipped with the full enzymatic machinery to accomplish the required post-translational modifications or molecular folding. Hence, multi-domain eukaryotic proteins expressed in bacteria often are non- functional. Also, many proteins become insoluble as inclusion bodies that are difficult to recover without harsh denaturants and subsequent cumbersome protein-refolding.

8 March 1901. pp. 967-980. Like all counties in Queensland, it is a non-functional administrative unit, that is used mainly for the purpose of registering land titles. From 30 November 2015, the government no longer referenced counties and parishes in land information systems however the Museum of Lands, Mapping and Surveying retains a record for historical purposes. The center of local government for the County is Jundah, Queensland to the north, the only town of the county is Windorah, Queensland and the postcode is 4481.

The same is true of amphibians – caecilians, Sirenidae (a clade of salamanders that are limbless except for atrophied front limbs), Amphiumidae (a clade of salamander with extremely atrophied limbs that appear non-functional) and at least three extinct groups (Aïstopoda, Lysorophia, and Adelospondyli). Larval amphibians, tadpoles, are also often limbless. Legless forms of reptiles and amphibians probably evolved so as to be able to move underground or in water more easily. Some analyses suggest that elongation and undulatory locomotion (slithering) evolved first, before limb loss.

ActiveArmor is a hardware firewall designed by Nvidia that's built into their higher range nForce4 Ultra chipset motherboards. It can reduce CPU load by making some simple layer 2 checks on incoming packets and discarding obviously malicious packets before they are sent to the CPU. It is an effective protection against some same subnet based attacks such as ARP poisoning, rogue DHCP servers and spoofed MAC addresses. The ActiveArmor hardware firewall is nearly non-functional, with many unsolved bugs and potentially serious instability issues.

Gysi's geometric theories of non-functional movement formed the basis of modern concepts of balanced occlusion. The studies illustrate the geometric variety of rotation centre about its asymmetrical location. To achieve this result, he relays a symmetrical fixed rotation on the articulator assuming that this can be used and ideal for complex anatomical situations. Using this concept, the patient can be trained to open their mandible without movement in the condylar path, demonstrated by McCollum and this movement point located in the condyle, called hinge axis.

Tughlaq's primary attention to infrastructure, particularly of iron supply to the city, was also well thought out. A structure (weir or tank) with seven sluices (Hindi:Satpula, meaning "seven bridges") was built on a stream that flowed through the city. This structure called the Satpula is still existing (though non-functional) near Khirki village on the boundary walls of Jahanpanah. Similar structures had also been built at Tughlaqabad and Delhi in Hauz Khas Complex, thus covering the water supply needs of entire population of Jahanpanah.

Some of the prisoners were as young as 12. Conditions in the stockade were poor: the prisoners had only concrete floors to sleep on, water only in drips from a shower, a single non-functional toilet, and poor food. The prison authorities did not inform the parents of the prisoners of their arrest or location, and they only found out through the help of a janitor. The young women were threatened with murder, and at one point a rattlesnake was thrown into their cell.

The telephone cupboard can be opened and the telephone accessed from the exterior. Although originally non-functional, as shown in "The Empty Child" (2005),episode: The Empty Child the TARDIS can be called from across space and time. When the TARDIS "died" with the Doctor in battle in an alternative timeline, it became his tomb on the grave fields of the planet Trenzalore. Although the tomb retains its police box exterior appearance, its interior volume begins to "leak", growing the exterior to hundreds of feet in height.

In December 2009, a working C65 on the online auction site eBay achieved a sales price of €6060. (dead link) A computer with missing parts was in October 2011 sold for about US$20,100. In April 2013 an eBay auction reached a price of 17,827 EUR. In February 2015 an eBay auction closed at 20,050 EUR. An eBay auction in November 2016 reached 15,605 EUR. On September 7, 2017 a non-functional C65 missing a VicIII chip, sold via eBay auction for US$18,350.00.

The Kozak consensus sequence (Kozak consensus or Kozak sequence) is a nucleic acid motif that functions as the protein translation initiation site in most eukaryotic mRNA transcripts. Regarded as the optimum sequence for initiating translation in eukaryotes, the sequence is an integral aspect of protein regulation and overall cellular health as well as having implications in human disease. It ensures that a protein is correctly translated from the genetic message, mediating ribosome assembly and translation initiation. A wrong start site can result in non-functional proteins.

Operational acceptance is used to conduct operational readiness (pre- release) of a product, service or system as part of a quality management system. OAT is a common type of non-functional software testing, used mainly in software development and software maintenance projects. This type of testing focuses on the operational readiness of the system to be supported, and/or to become part of the production environment. Hence, it is also known as operational readiness testing (ORT) or Operations readiness and assurance (OR&A;) testing.

Functional testing refers to activities that verify a specific action or function of the code. These are usually found in the code requirements documentation, although some development methodologies work from use cases or user stories. Functional tests tend to answer the question of "can the user do this" or "does this particular feature work." Non-functional testing refers to aspects of the software that may not be related to a specific function or user action, such as scalability or other performance, behavior under certain constraints, or security.

In response, young architects who had worked in Europe and returned to Australia brought a simplicity to design and construction and renewed interest in logical structure and free planning. Verandahs and porches were less common on houses, and slightly pitched roofs replaced hipped roofs. Designs no longer featured non-functional ornamentation, ceilings were lower and rooms were expected to be multi-purpose. Vestibules were eliminated, hallways, and separate dining and living rooms were eliminated and the main entry was directly into the living room.

Single- sided deafness (SSD) and conductive hearing loss (CHL) are life-altering conditions where patients often have anxiety, depression, social isolation, and reduced quality of life. SSD patients have one cochlea that is virtually non-functional. It does not hear sound even when using conventional hearing aids, which are amplification devices that simply “turn up the volume” on air- conducted sound. CHL patients have a problem with the ear (outer, middle or canal) that prohibits air conducted sound from reaching an otherwise functional cochlea.

Similar to other 1960s vehicles with fastback rooflines, its rear window was "tunneled", with large rear C-pillars. In the rear quarter panels, non-functional louvered side air intakes were added as a styling element. By the end of the 1960s, demand for high- performance full-size cars had largely disappeared. In total, Mercury would sell about 15,000 examples for 1969, and barely a third of that for 1970; in comparison to the Marauder, Mercury would sell nearly 173,000 Cougars at the same time.

Attack resistance is an important non-functional property of trust metrics which reflects their ability not to be overly influenced by agents who try to manipulate the trust metric and who participate in bad faith (i.e. who aim to abuse the presumption of trust). The free software developer resource Advogato is based on a novel approach to attack-resistant trust metrics of Raph Levien. Levien observed that Google's PageRank algorithm can be understood to be an attack resistant trust metric rather similar to that behind Advogato.

RNA editing is the insertion, deletion, and substitution of nucleotides in a mRNA transcript prior to translation to protein. The highly oxidative environment inside chloroplasts increases the rate of mutation so post-transcription repairs are needed to conserve functional sequences. The chloroplast editosome substitutes C -> U and U -> C at very specific locations on the transcript. This can change the codon for an amino acid or restore a non-functional pseudogene by adding an AUG start codon or removing a premature UAA stop codon.

In mammals, acid-sensing ion channels (ASIC) are encoded by five genes that produce ASIC protein subunits: ASIC1, ASIC2, ASIC3, ASIC4, and ASIC5. Three of these protein subunits assemble to form the ASIC, which can combine into both homotrimeric and heterotrimeric channels typically found in both the central nervous system and peripheral nervous system. However, the most common ASICs are ASIC1a and ASIC1a/2a and ASIC3. ASIC2b is non-functional on its own but modulates channel activity when participating in heteromultimers and ASIC4 has no known function.

Each sub-category is sized, and the size of a requirement is the sum of the sizes of its sub-categories. The SNAP sizing process is very similar to the Function Point sizing process. Within the application boundary, non-functional requirements are associated with relevant categories and their sub-categories. Using a standardized set of basic criteria, each of the sub-categories is then sized according to its type and complexity; the size of such a requirement is the sum of the sizes of its sub- categories.

Sanction of OROP at apex scale to all civil services and Police officers was accompanied by grant of "Non Functional Upgrade" (NFU) also called "non- functional financial up-gradation" (NFFU) to all civil services including the Indian Police Service by the Congress(I) led United Progressive Alliance(UPA) Government, in 2008, to reward civil servants of 49 'Organized Central Group A Services', with automatic time bound pay promotions till the Higher Administrative Grade(HAG), a grade equated by Government with Lt Generals, Vice Admirals, and Air Marshals of Armed Forces. The unexplained exclusion of Armed Forces officers corps from the NFU, despite representation by the Chief of Staff, has wide-ranging implications : it impacts adversely the pay and pension structures, of colonels, brigadier and generals, and their equivalents in the navy and the air-force; it like OROP, become an emotive 'honor' issue; and, according to former senior military commanders, has had a corrosive impact on the Armed Forces morale, status, cohesion, and national security, Despite the serious long term implications of NFU, the issue was ignored by the UPA government, and even the BJP Government has chosen not to dwell on it.

Fantaasia at Strömstad during her charter to Kystlink. Following the second Algérie Ferries charter, the Fantaasia was chartered to the Norway- based Kystlink Varden: Kystlink hyrer finsk ferje, retrieved 10 October 2007 for three months (with an option for three additional months) from October 2007 onwardsOMX Group: CORRECTION: Chartering Fantaasia, retrieved 19 October 2007 to replace their MS Pride of Telemark that was out of service following an accident when the ship rammed the breakwater at Hirtshals, Denmark.Aftenposten english article reprinted at the FCBS Forum, retrieved 18 October 2007 Before entering service for Kystlink, Fantaasia was docked at Cityvarvet, Gothenburg. FCBS Forum: Fantaasia vuokrataan Kystlinkille?, retrieved 18 October 2007 On 15 November, the Swedish Maritime Authority Sjöfartsinspektionen deemed the ship unsafe and prohibited it from leaving Cityvarvet until 18 faults found during the inspection were fixed. Göterborgs- Posten 17. 11. 2007: Färja kvar i hamn med allvarliga fel, retrieved 17 November 2007 Twelve of the faults were considered severe, including several permanently open watertight doors, a non-functional loudspeaker system, blocked emergency exists and non-functional winches used for lowering lifeboats. GT.se 17. 11.

Pontiac also produced a single 1973 Grand Am station wagon as a feasibility study. This was a LeMans wagon converted to a Grand Am. A functional ram-air induction system was developed for the Pontiac A-bodies utilizing twin NACA openings in the hood, but the option was dropped due to inability to pass federally mandated drive-by noise standards. A few functional Ram Air systems were sold over the counter. The twin-scoop NACA hood was an option for any Pontiac A-body for all three years, but was non- functional.

The trade commodities included in the definition of "visual art" include the following: painting, drawing, sculpture in various materials, printmaking, photography, maps, performance art, installation art, mail art, assemblage art, textile arts, fashion design, video art, digital art, and product design. These works are non-functional, emotional, social, political, traditional, and cultural statements, and in comparison to other goods, are not greatly affected by commercial-sector constraints. Though visual art is a physical, hand-made good, it is often culturally rooted and created for aesthetic appeal. Therefore, art is considered intellectual property.

PSS also gives feedback to Microsoft development groups for use in the development of future products or product features. The Windows 2000 recovery console, for instance, was developed in large part to address difficulty that PSS agents had when attempting to assist customers with non-functional Windows NT installations. Additionally, PSS identifies major issues with products, and works with the responsible product teams in order to create "hotfixes" for these issues, and/or make sure that the issues are addressed in service packs or future product versions. It is a type of Call Center.

Critics say the legend of the Dragon did not pass the test of time. The complex, five-motor transport, which was once hailed as "a masterpiece of engineering" and an "engineering tour de force", was not as robust as simpler, unidirectional transports. The Dragons that are sold at internet auctions need extensive repairs; the small number of Nakamichi service technicians is shrinking and parts must be scavenged from non-functional Dragons. The cost of a complete overhaul in 2014 was comparable with the price of a new deck in the 1990s.

Human gamma- glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma- glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes.

The Fabric Workshop and Museum was founded in 1977 by Marion Boulton Stroud. Stroud's goal was to create a non-profit workshop that combined team-work and innovation. The Artists in Residency program provided space, tools and assistance for the artists to make functional objects through screen printing on fabric. When FWM saw that artists ideas, especially the installation based, were being stifled in the process of translating their ideas into a functional objects, they dropped that principle and allowed the work to be non-functional as well.

This is another model based on the TE1A in the form of a showman's road locomotive. Like the real-life showmans' engines, it uses the basic form of a traction engine with the addition of a dynamo and a few aesthetic details. The Showman's model has twisted-brass canopy supports, a (non-functional) chain-steering drum and a typical bright paint scheme with a maroon boiler and yellow wheels. The main mechanical differences between the Showman's and the TE1A are the dynamo and the fitting of a solid flywheel to the former model.

The Maserati Boomerang was a concept car designed by Giorgetto Giugiaro. It was first revealed at the Turin Motor Show in 1971 as a non-functional model, but by the time of the 1972 Geneva Auto Show the company had developed it into a commercially launched Maserati Bora. Maserati Boomerang (rear) The Boomerang was registered as a road car, but it was intended as a one-off show car. It was shown in dozens of places, and after the 1974 car show in Barcelona it was sold to a private individual.

Secondly, it is also associated with a strongly reduced/atrophic size of apocrine sweat glands and a decreased protein (such as ASOB2) concentration in axillary sweat. The non-functional ABCC11 allele is predominant among East Asians (80–95%), but very low in other ancestral groups (0–3%). Most of the world's population have the gene that codes for the wet- type earwax and normal body odor; however, East Asians are more likely to inherit the allele associated with the dry-type earwax and a reduction in body odor.

However, the beacons that the player finds are damaged or otherwise non-functional, forcing further exploration. As the game proceeds, more promotional videos emerge from UExplore talking about how safe their program is - so much so, in fact, that the company's safety director was given an extended vacation. The player eventually comes upon an alien installation that has the ability to alter reality in short bursts. The Small Craft penetrates this installation's defenses and causes a massive explosion, resulting in the ship being sent back to the surface, heavily damaged.

That mutation occurred in the gene called Serpine1, which codes for the production of the protein PAI-1 (plasminogen activator inhibitor), which regulates blood clotting and plays a role in the aging process. About 24% of the people sampled carried this mutation and had a life expectancy of 85, higher than the community average of 75. Researchers also found the telomeres—non-functional ends of human chromosomes—of those with the mutation to be longer than those without. Because telomeres shorten as the person ages, they determine the person's life expectancy.

Tata Steel and BCCL are the major coal companies in Sijua. The Sijua Area of BCCL is composed of: Basdeopur colliery (underground), Kankanee colliery (UG and open cast), Loyabad colliery (UG) (mostly non-functional), Mudidih colliery (UG and OC), Nichitpur Colliery (OC), Sendra Bansjora colliery (UG and OC) and Tetulmari colliery (UG and OC). Tata Steel leased six coal mines with metallurgical coal in Jharia coalfield between 1910 and 1918, These are grouped in two locations – Sijua and Jamadoba. The Bhelatand colliery of the Sijua Group was then acquired.

Soon it will become difficult to manage the growing changes and additions which would result in making system integrations non- functional. Hence utilities cannot make use of the complete benefit of functional modules and in some cases; the systems may even need to be migrated to suitable environments with very high costs. As these problems came to light, various standardization processes for inter application data exchanges were initiated. It was understood that a standard based integration shall ease the integration with other functional modules and that it also improves the operational performance.

IBM's CCRA is based on real-world input from many cloud implementations across IBM. It is intended to be used as a blueprint/guide for architecting cloud implementations, driven by functional and non-functional requirements of the respective cloud implementation. HP and Microsoft have also published Cloud Computing Reference Architectures. Within the IaaS space, IBM is a member of the Cloud Management Work Group (CMWG) within the Distributed Management Task Force (DMTF), which released a draft version of their IaaS APIs, called the Cloud Infrastructure Management Interface (CIMI), on September 14, 2011.

The appearance of the fourth abdominal segment is consistent with almost all aculeate insects, and possibly Sphecomyrma. The feature of non-functional, vestigial wings may have evolved in this species relatively recently, as wings might otherwise have long-since disappeared completely had they no function for dispersal. Wing-reduction could somehow relate to population structure or some other specialised ecological pressure. Equally, wing-reduction might be a feature that only forms in drought-stressed colonies, as has been observed in several Monomorium ant species found throughout semi-arid regions of Australia.

Needham's Point Lighthouse as seen from the coastline The octagonal lighthouse was constructed in 1855 at the southern end of Carlisle Bay. It is currently non-functional and partially restored by the Hilton Hotel which owns the lighthouse and surrounding grounds. Because of the proximity of a large block of rooms, the lighthouse can only be seen from the beach to the south of the hotel.Fun Barbados : Needham's Point Lighthouse During its period of active use the lighthouse's focal plane stood at 43 ft / 13 m and flashed at an 8-second interval.

The Unix-Haters Handbook covers some of these design features as failures from the user point of view. However, although some information is quite dated and cannot be applied to modern Unixes or Unix-like operating systems such as Linux, Eric S. Raymond discovered that several issues are still prevailing, while others were resolved. Raymond concludes that not all concepts behind Unix can be deemed as non-functional even though the book's intention may have been to portray Unix as inferior without encouraging discussions with developers to actually fix the issues.

In the manufacturing of micro-electronic devices, die cutting, dicing or singulation is a process of reducing a wafer containing multiple identical integrated circuits to individual dies each containing one of those circuits. During this process, a wafer with up to thousands of circuits is cut into rectangular pieces, each called a die. In between those functional parts of the circuits, a thin non- functional spacing is foreseen where a saw can safely cut the wafer without damaging the circuits. This spacing is called the scribe line or saw street.

Gallium (III) ion shows anti-inflammatory activity in animal models of inflammatory disease. Orally administered gallium maltolate has demonstrated efficacy against two types of induced inflammatory arthritis in rats. Experimental evidence suggests that the anti-inflammatory activity of gallium may be due, at least in part, to down-regulation of pro-inflammatory T-cells and inhibition of inflammatory cytokine secretion by macrophages. Because many iron compounds are pro-inflammatory, the ability of gallium to act as a non-functional iron mimic may contribute to its anti-inflammatory activity.

Lowry departed Norfolk early in April 1968, passing thru the Panama Canal on Easter Sunday, then continuing for the Far East on her first 7th Fleet deployment of the Vietnam War. Serving off the coast, she performed plane guard, naval gunfire support, and other duties for which the versatile destroyer was well suited. Highlights of port visits were visits to: Bangkok, Thailand; Sasebo and Yokosuka Japan; Hong Kong; Pusan, Korea; and the Philippines. Lowlights included a collision at sea while highlining, and monsoon seas with one of two screws non-functional.

However, telomere degeneration can also induce tumorigenesis in other cells. The key difference is the presence of a functional p53 damage response. When tumor cells have a mutation in p53 that results in a non- functional protein, telomeres can continue to shorten and proliferate, and the eroded segments are susceptible to chromosomal rearrangements through recombination and breakage-fusion-bridge cycles. Telomere loss can be lethal for many cells, but in the few that are able to restore the expression of telomerase can bring about a “stable” yet tumorigenic chromosome structure.

Beginning in the late 1890s, Novák began to explore influences beyond the prevailing Wagner/Brahms aesthetic of his contemporaries in Prague. Among these were folk influences from Moravia and Slovakia, which at that time were considered culturally backward in the cosmopolitan Czech capital. He also developed an interest in what would come to be called musical Impressionism, although in later life he denied any exposure to the music of Debussy at this time, claiming instead to have arrived at similar techniques on his own. These included forays into bitonality and non-functional, parallel harmony.

One of the last luxury ocean-liners of the company was ship Virginia de Churruca, sold to Trasmediterránea which used it for ferry services to the Balearic Islands. The profits from sales like these, undertaken "at the point of death", were minimal. In 1978 a non-functional Compañía Transatlántica Española, was integrated into the Instituto Nacional de Industria (INI), an entity of the Spanish state that absorbed failed companies in order to service debt, among other purposes. In 1994 "La Transatlàntica" became a private company after being acquired by Naviera del Odiel.

Furthermore, greater activation was associated with greater amounts of eye contact and better social functioning. Scientists believe the inferior frontal gyrus is one of the main neural correlates with the mirror neuron system in humans and is often related to deficits associated with autism. These findings suggest that the mirror neuron system may not be non-functional in individuals with autism, but simply abnormal in its development. This information is significant to the present discussion because mu waves may be integrating different areas of mirror neuron activity in the brain.

In most cases the mutations in Dravet syndrome are not hereditary and the mutated gene is found for the first time in a single family member. In 70–90% of patients, Dravet syndrome is caused by nonsense mutations in the SCN1A gene resulting in a premature stop codon and thus a non-functional protein. This gene normally codes for neuronal voltage-gated sodium channel Na(V)1.1. In mouse models, these loss-of-function mutations have been observed to result in a decrease in sodium currents and impaired excitability of GABAergic interneurons of the hippocampus.

However, the meniscus has poor blood supply, and, therefore, healing can be difficult. Traditionally it was thought that if there is no chance of healing, then it is best to remove the damaged and non-functional meniscus, although at least one study has shown that there is little significance if a meniscectomy is done. However, resuming high intensity activities may be impossible without surgery as the tear may flap around, causing the knee to lock. A 2017 clinical practice guideline strongly recommends against surgery in nearly all patients with degenerative knee disease.

The prolonged public silence of Nvidia, after promising updated drivers, and test benchmarks gathered by users led the user community to conclude that the WMV9 decoder component of the AGP 6800's PureVideo unit is either non-functional or intentionally disabled. In late 2005, an update to Nvidia's website finally confirmed what had long been suspected by the user community: WMV-acceleration is not available on the AGP 6800. Of course, today's standard computers are fast enough to play WMV9 video and other sophisticated codecs like MPEG-4, H.264 or VP8 without hardware acceleration.

Exposed trees battered by coastal winds are often twisted into beautiful sculptural shapes resembling large bonsai, and rarely exceed tall. The seeds are eaten by birds and rodents. Like most pine tree species, the seeds have a wing attached to them, but in this species it is papery, breaks off easily, and is entirely non-functional, so this tree is entirely reliant upon animals to disperse its seeds. The scrub jay (Aphelocoma californica) is the most important species when it comes to dispersal of the seeds (on the mainland).

These mutations may impair activity by significantly reducing the steady- state level of the protein, rather than produce a non- functional mutant protein. Mutations of the β-enolase dimer complexes might result in incorrect folding and increased susceptibility to protein degradation thus causing the deficiency. Similar mutations on yeast showed destabilization of the protein and decreased substrate affinity. Destabilization of the protein results in partial dissociation, some researchers propose that in muscle cells this dissociation may be perceived as an abnormality leading to degradation of the mutated enolase.

The non-functional side scoops between the doors and rear wheel arches were removed, and the taillights moved from the body into the rear bumper. A vinyl roof became available as an option, initially offered only in black, and the tilt steering wheel optional in previous years was now standard equipment. Total sales for the 1963–1965 model years was a respectable 112,244. The Riviera was extremely well received from all quarters and considered a great success, giving the Thunderbird its first real competition as America's preeminent personal luxury car.

The SJC proceedings began 45 minutes late than the scheduled time. Barrister Aitzaz Ahsan presented his arguments before the council. He argued before the SJC that the non-functional chief justice wants open trial of the reference and called for the open trial as the nation come to know the truth of the charges against Justice Iftikhar Chaudhry. Meanwhile, Federal Minister for Information Muhammad Ali Durrani, talking with Geo News, said that the government has not interfered anywhere and given chance to all sides to express their opinions.

Strict security measures have been taken in Islamabad on the hearing of presidential reference against non-functional Chief Justice Iftikhar Muhammad Chaudhry here on Friday. Additional contingents of law enforcement forces were deployed in Islamabad whereas FC put on stand- by position. Strict surveillance also carried out at entry and exit routes of the city. A separate traffic plan has been prepared to maintain traffic flow in the capital, however, traffic jam was reported in different areas of Islamabad including Faizabad, a main entry route of the city.

Vertical stratification including an aerobic surface layer, an anaerobic bottom layer, and a facultative intermediate layer is essential to proper functioning of a facultative lagoon ecosystem. Stratification is maintained by a thermal gradient of cool, dense water at the bottom of the lagoon overlain by warmer, less dense water on the surface. This thermal gradient becomes unstable when water reaches its maximum density at 4 degrees Celsius (39 degrees Fahrenheit). Facultative lagoons are impractical in cold climates, because the lagoons become non-functional when cooler air temperatures depress water temperatures below this critical value.

In non-functional linguistics, a sentence is a textual unit consisting of one or more words that are grammatically linked. In functional linguistics, a sentence is a unit of written texts delimited by graphological features such as upper case letters and markers such as periods, question marks, and exclamation marks. This notion contrasts with a curve, which is delimited by phonologic features such as pitch and loudness and markers such as pauses; and with a clause, which is a sequence of words that represents some process going on throughout time.Halliday, M.A.K. and Matthiessen, C.M.I.M. 2004.

Indeed, hPG80 is more than 700 times more abundant than amide gastrin in colorectal tumors. In the early 90s, it was shown that hPG80 was not fully matured in human colon cancer cell lines and, more importantly, that it was secreted by in vitro cells. These observations led to the study of autocrine and paracrine function of hPG80 in tumor cells. Generally, it has been shown that hPG80 does not mature properly in cancer cells, particularly in colorectal cancer, because maturation enzymes are either absent or non- functional.

During 1929 the original wheels and one cylinder were incorporated into a full scale, non-working model that is now on display in the Manchester Museum of Science and Industry. This early replica was rebuilt in 1988 and currently includes batteries and an electric motor to allow it to move (all wheels are driven making the engine a 4wBE), although the steam components are non-functional. The other cylinder is on display at Rainhill Public Library. No other British locomotives are known to have been built in this style.

An access door to the left of the viewing window leads to the execution room. Immediately to the right of the observation room (but still within it) is a storage area that houses the non-functional electric chair (nicknamed "Old Sparky") that was used before the implementation of lethal injection. The execution chamber proper is approximately 8' X 12' and is occupied by a gurney outfitted with sheets and pillow. Continuing through the execution chamber, there is a holding room off the right side as viewed from the observation room with a single-cell complex.

46,XX gonadal dysgenesis is characteristic of female hypogonadism with a karyotype of 46,XX. Streak ovaries are present with non-functional tissues unable to produce the required sex steroid oestrogen Low levels of oestrogen effect the HPG axis with no feedback to the anterior pituitary to inhibit the secretion of FSH and LH. FSH and LH are secreted at abnormal elevated levels. Improper levels of these hormones will cause a failure to initiate puberty, undergo menarche, and develop secondary sex characteristics. If sufficient functional ovarian tissue is present, limited menstrual cycles can occur.

Professional bassists are more likely to have adjustable bridges, which have a metal screw mechanism. This enables the bassist to raise or lower the height of the strings to accommodate changing humidity or temperature conditions. The metal tuning machines are attached to the sides of the pegbox with metal screws. While tuning mechanisms generally differ from the higher- pitched orchestral stringed instruments, some basses have non-functional, ornamental tuning pegs projecting from the side of the pegbox, in imitation of the tuning pegs on a cello or violin.

Study of the French specimen indicated that the third digit bore at least one or two small phalanges. However, there remains no evidence for an unugal phalanx on the third digit, so the digit may have been reduced and non- functional. Bidar supposed that the French specimen had webbed hands, which would look like flippers in life. In the 1975 book The Evolution and Ecology of the Dinosaurs, L. B. Halstead depicts the animal as an amphibious dinosaur capable of feeding on aquatic prey and swimming out of reach of larger predators.

I2PP2A does not inhibit CAPP in vitro but has been proven to inhibit CAPP in vivo (Janssens & Goris, 2001). I2PP2A mainly acts as an inhibitor by binding to the catalytic subunit, causing a conformational change, and rendering it non-functional (Janssens & Goris, 2001). In the presence of physiological Mn2+ concentrations, I2PP2A can associate with and stimulate the activity of PP1 but Mn2+ does not seem to affect the inhibition of PP2A through I2PP2A, in vitro (Janssens & Goris, 2001). I2PP2A has also been identified as a truncated SET protein (Janssens & Goris, 2001).

The failure of extensionSingh, J., Scriven, J. , Clemente, M. , Lomax, W. and Wright, M. (2012), "New Brand Extensions: Patterns of Success and Failure," Journal of Advertising Research, Vol. 52, No. 2, pp. 234–242 may come from difficulty of connecting with parent brand, a lack of similarity and familiarity and inconsistent IMC messages. "Equity of an integrated oriented brand can be diluted significantly from both functional and non-functional attributes-base variables", which means dilution does occur across the brand extension to the parent brand.Chen, C.H. Chen, S.K. (2000).

Epidemiological studies have shown that individuals with different ABO(H) (histo-blood group) phenotypes are infected with NoV strains in a genotype-specific manner. GII.4 includes global epidemic strains and binds to more histo-blood group antigens than other genogroups. FUT2 fucosyl-transferase transfers a fucose sugar to the end of the ABO(H) precursor in gastrointestinal cells and saliva glands. The ABH-antigen produced is thought to act as a receptor for human norovirus: A non-functional fucosyltransferase FUT2 provides high protection from the most common norovirus strain, GII.4.

Both genes by themselves produce non-functional peptides, however, when expressed together, as when a plasmid containing lacZ-α is transformed into a lacZΔM15 cells, they form a functional β-galactosidase. The presence of an active β-galactosidase may be detected when cells are grown in plates containing X-gal, forming characteristic blue colonies. However, the multiple cloning site, where a gene of interest may be ligated into the plasmid vector, is located within the lacZα gene. Successful ligation therefore disrupts the lacZα gene, and no functional β-galactosidase can form, resulting in white colonies.

Biosynthesis of the 17C monic acid unit begins on MmpD (Figure 1). One of the AT domains from MmpC may transfer an activated acetyl group from acetyl- Coenzyme A (CoA) to the first ACP domain. The chain is extended by malonyl- CoA, followed by a SAM-dependent methylation at C12 (see Figure 2 for PA-A numbering) and reduction of the B-keto group to an alcohol. The dehydration (DH) domain in module 1 is predicted to be non-functional due to a mutation in the conserved active site region.

It is the home of the Burns Monument, a large monument to poet Robert Burns. The Burns Monument was badly damaged by fire in November 2004, however it was later redeveloped to provide a marriage suite, registration service and local history research service. There was formerly a miniature golf course, a few drinking fountains, pubs, boating in the pond and a band stand on the site, but now only a single non- functional fountain remains. The Kilmarnock-Dumfries railway line passes the park, although the line is used for freight rather than passenger trains.

The prototype is implemented using paper and pencil, and thus mimics the function of the actual product, but does not look at all like it. Another method to easily build high fidelity throwaway prototypes is to use a GUI Builder and create a click dummy, a prototype that looks like the goal system, but does not provide any functionality. The usage of storyboards, animatics or drawings is not exactly the same as throwaway prototyping, but certainly falls within the same family. These are non-functional implementations but show how the system will look.

Mutations in HNRNPK that have been reported include nonsense mutations, in which the protein is truncated and usually non-functional as a result, frameshift mutations, splice-site mutations and microdeletions encompassing the gene. Rarely, missense mutations, in which one amino acid in the protein is replaced by another, have also been reported. Deletions in the region encompassing HNRNPK have been found in the cells of acute myeloid leukemia in approximately 2% of cases. Acute myeloid leukemia cells are immature white blood cells (myeloblasts) that remain in the stem-cell stage, dividing continually.

Detailed analysis and comparison of fresh specimens revealed that what had been collectively called "S. coccinea" actually consisted of four distinct species: S. austriaca, S. coccinea, S. dudleyi, and S. jurana. The phylogenetic relationships in the genus Sarcoscypha were analyzed by Francis Harrington in the late 1990s. Her cladistic analysis combined comparisons of the sequences of the internal transcribed spacer in the non-functional RNA with fifteen traditional morphological characteristics, such as spore features, fruit body shape, and degree of curliness of the "hairs" that form the tomentum.

The fins are connected to the shoulder by a single bone, which is a marked difference from most fish, whose fins usually have at least four bones at their base, and a marked similarity with nearly all land-dwelling vertebrates."Your Inner Fish" Neil Shubin, 2008,2009,Vintage, p.33 The gills are greatly reduced and essentially non-functional in the adults. left Juvenile lungfish feed on insect larvae and snails, while adults are omnivorous, adding algae and shrimp to their diets, crushing them with their heavily mineralized tooth-plates.

To date, several groups of constructions have been uncovered in the region, which loosely follow late Classic Río Bec architectural canons. Structure I is the most notable structure in this region, due to its atypical three-tower construction instead of the usual two. This structure includes three towers, roof combs, steep stairways, and non-functional doors. It is hypothesized that it may have been constructed in an effort to mimic the style of pyramid-temples found in Tikal and elsewhere. Characteristic of the architectural style found at Xpuhil is the construction of “false” temples.

The term "software multitenancy" refers to a software architecture in which a single instance of software runs on a server and serves multiple tenants. Systems designed in such manner are often called shared (in contrast to dedicated or isolated). A tenant is a group of users who share a common access with specific privileges to the software instance. With a multitenant architecture, a software application is designed to provide every tenant a dedicated share of the instance - including its data, configuration, user management, tenant individual functionality and non-functional properties.

The SV1 Valiant (or "S Series" ) was introduced in March 1962, replacing the Chrysler Valiant (RV1)—also known as the "R Series"—only ten weeks after the release of its predecessor.Gavin Farmer, Great Ideas in Motion, page 107 Like the RV1 it was essentially a US design just assembled in Australia. It was an evolution of the previous model, featuring a revised radiator grille treatment with the name "Valiant" at the top. The boot lid no longer included a non- functional spare wheel moulding and round tail-lights replaced the previous oblong units.

Findings of potentially functional pseudogenes creates difficulty in defining them, since the term was originally meant for degenerate sequences with no biological function. An example of a pseudogene is the gene for L-gulonolactone oxidase, a liver enzyme necessary for biosynthesis of L-ascorbic acid (vitamin C) in most birds and mammals, but which is mutated in the haplorrhini suborder of primates, including humans which require ascorbic acid or ascorbate from food. The remains of this non- functional gene with many mutations is still present in the genomes of guinea pigs and humans.

The mill drove two pairs of millstones, flour dressers, wheat cleaners and other machinery. The mill as it appeared with decorative, non-functional sails and bronze cap prior to the 2012 restoration The construction of the mill was part of a broader program to enable the Jews of Palestine to become self-supporting. Montefiore also built a printing press and a textile factory, and helped to finance several agricultural colonies. He attempted to acquire land for Jewish cultivation, but was hampered by Ottoman restrictions on land sale to non-Muslims.

The phylogenetic relationships in the genus Sarcoscypha were analyzed by Francis Harrington in the late 1990s. The cladistic analysis combined comparison of sequences from the internal transcribed spacer in the non-functional RNA in addition to fifteen traditional morphological characters, such as spore features, fruit body shape, and degree of hair curliness. Based on this analysis, one major clade includes the species S. austriaca, S. macaronesica, S. knixoniana and S. humberiana, while another has S. korfiana, S. occidentalis, S. mesocyatha, S. dudleyi, S. emarginata, and S. hosoyae. S. jarvensis is sister to all these species.

Individual regions within an miRNA gene face different evolutionary pressures, where regions that are vital for processing and function have higher levels of conservation. At this point, a microRNA is rarely lost from an animal's genome, although newer microRNAs (thus presumably non-functional) are frequently lost. In Arabidopsis thaliana, the net flux of miRNA genes has been predicted to be between 1.2 and 3.3 genes per million years. This makes them a valuable phylogenetic marker, and they are being looked upon as a possible solution to outstanding phylogenetic problems such as the relationships of arthropods.

Guiler has reported that consecutive hermaphroditism (sex change) has occurred in captured devils, while Pemberton and Mooney recorded in 2004 the case of an animal with a scrotum and a non- functional pouch.Owen and Pemberton, p. 54. In an apparent response to reduced competition caused by devil facial tumour disease, female devils in regions with the disease are now more likely to begin breeding at the age of one year. The disease has also led to the reproductive season being less well-defined, with births more spread out throughout the year.

OSCA bought engines built by Fiat for their own purposes, and fettled those units further. The new model was called the Fiat 1500 Cabriolet (tipo 118S) and received a wider (non-functional) air scoop on the bonnet, a rev counter, as well as the larger drum brakes from the larger 1800/2100 saloons, and 15-inch wheels. In July 1960 the name was changed to "Fiat 1500 S Cabriolet," and it now had disc brakes front and rear. About 1000 of the OSCA-engined 1500/1500 S models were built.

The armed forces have alleged their salaries have been "artificially suppressed", which have affected armed forces time scale ranks of captain, majors, and lt colonels, and selection grade ranks of colonel, and brigadiers. (b) The award of non-functional upgrade (NFU) by 6CPC to the civilian services and the police, while denying it to the armed forces. The armed forces demanded that it be extended to the Armed forces on for same reasons it has been granted to other government servants. (c) Increase military service pay (MSP) for Junior Commissioned Officers (JCOs) to Rs 10,000.

Conditions in the stockade were poor: the prisoners had only concrete floors to sleep on, water only in drips from a shower, a single non-functional toilet, and poor food. The prison authorities did not inform the parents of the prisoners of their arrest or location, and they only found out through the help of a janitor. The young women were threatened with murder, and at one point a rattlesnake was thrown into their cell. After the SNCC and Senator Harrison A. Williams used a set of photos by Danny Lyon to publicize the situation,.

In rocketry, a battleship was a term used during the design of the Saturn V to refer to a heavy duty rocket stage which was used to test configuration and integration of a launch vehicle. The term was used in contrast to the boilerplate nickname, which refers to a non-functional mock-up used to test spacecraft. A battleship is functional, but simpler, cheaper and heavier than the operational version. Thus, it functions but does not achieve the same performance (such as thrust-to-weight ratio) as the operational one.

Thus a black horse has at least one copy of the functional, dominant "E" allele and two copies of the non-functional, recessive "a" allele. A mature true black horse can be safely said to possess at least one dominant extension gene (EE or Ee); and has no other dominant genes (such as agouti, gray, or any of the dilution factors) that further modify color. A DNA test, which uses hair with the root intact, has been developed to test for the Extension and Agouti genotypes. However, the terminology can be manipulated.

Thus, mutations of a structural gene should produce loss of function mutations where the gene product is absent or non-functional, gain of function mutations where the functional properties of the gene product is changed, and position effect mutations where a breakpoint near the gene reduces expression of a normal gene product. All three classes of mutations were characterized by Salkoff, e.g. 1. Loss-of-function mutant ( ShrKO120) which removed the Shaker K+ current. 2\. Gain-of-function mutant (Sh5) (which changed the inactivation kinetics of the current, 3\.

The thick walls of the citadel are protected by a non- functional moat. An inner area, measuring some 400m by 375m, contains several interesting archaeological remains. The courtyard of the palace is enclosed by galleries and a central structure, reached by stone steps, to the left of which can be seen an asana (stone seat). An inscription in the first room on the south side relates that King Nissanka Malla (1187-1196AD), who succeeded Parakramabahu, visited this spot to witness dance performances in the decade following Parakramabahu’s death.

The County of Bentinck is a county located on the southern boundary of the state of Queensland, Australia. Like all counties in Queensland, it is a non- functional administrative unit, that is used mainly for the purpose of registering land titles. The county was named in 1838 after William Cavendish- Bentinck, 3rd Duke of Portland, who served as Prime Minister of Great Britain twice, in 1783 and again between 1807 and 1809. Population centres within the County of Bentinck include the towns of Stanthorpe, Wallangarra, Glen Aplin, Applethorpe and Inglewood.

Sucrose intolerance or genetic sucrase-isomaltase deficiency (GSID) is the condition in which sucrase-isomaltase, an enzyme needed for proper metabolism of sucrose (sugar) and starch (e.g., grains), is not produced or the enzyme produced is either partially functional or non-functional in the small intestine. All GSID patients lack fully functional sucrase, while the isomaltase activity can vary from minimal functionality to almost normal activity. The presence of residual isomaltase activity may explain why some GSID patients are better able to tolerate starch in their diet than others with GSID.

Scalability testing, is the testing of a software application to measure its capability to scale up or scale out in terms of any of its non-functional capability. Performance, scalability and reliability testing are usually grouped together by software quality analysts. The main goals of scalability testing are to determine the user limit for the web application and ensure end user experience, under a high load, is not compromised. One example is if a web page can be accessed in a timely fashion with a limited delay in response.

Volume Testing belongs to the group of non-functional tests, which are often misunderstood and/or used interchangeably. Volume testing refers to testing a software application with a certain amount of data. This amount can, in generic terms, be the database size or it could also be the size of an interface file that is the subject of volume testing. For example, if you want to volume test your application with a specific database size, you will expand your database to that size and then test the application's performance on it.

Owens-Corning was issued a trademark for the color pink used to color its fiberglass batting insulation product. The decision was based upon the fact that the company had been emphasizing the pink color of its insulation for decades, had licensed use of the Pink Panther cartoon character in its ads, the color was a non- functional aspect of the product (fiberglass is normally tan or yellow), and Owens Corning had spent over US$50 million advertising its insulation product. In re Owens-Corning Fiberglas Corp., 774 F.2d 1116 (Fed. Cir. 1985).

1981 Ford Mustang Cobra hatchback The Cobra appearance package also made its debut in 1979 and would continue through both the 1980 and 1981 model years. The 1979 Cobra (17,579 produced) featured black grille, trim and moldings (with the exception of the sail panels which were painted body color), as well as black lower body paint. The door handles, door locks, antenna, and roof drip rail were bright. Color- coordinated dual pinstripes in the wraparound body-side moldings and bumpers, as well as COBRA decals on the doors were standard. All Cobras came equipped with a small, center mount non functional hood scoop (to provide clearance for the air cleaner due to the turbocharged 2.3's extra height), and the Cobra hood decal was optional for 1979. Rear spoilers were not included on the 1979 models, as they made their debut on the mid year introduction of the Indianapolis 500 Pace Car replica. The 1980 Cobra (5,550 produced) and the 1981 Cobra (1,821 produced) received a new front bumper and air dam with fog lights, non functional cowl-type hood scoop, and rear spoiler (all carried over from the earlier Pace Car replicas). Graphics included belt-line stripes, a redesigned hood decal, and "COBRA" decals on both the side quarter windows and the rear spoiler.

To help build and configure the SCA System, Composites can be used as component implementations, in the same way as Java classes or BPEL processes. In other words, SCA allows a hierarchy of composites that is arbitrarily deep – such a nested model is termed recursive. The capture and expression of non-functional requirements, such as security, is an important aspect of service definition, and affects SCA throughout the life-cycle of components and compositions. SCA provides the Policy Framework to support specification of constraints, capabilities and Quality of Service (QoS) expectations, from component design through to concrete deployment.

A photo of the only known SNES-based PlayStation prototype In November 2015, it was reported that one of the original "Nintendo PlayStation" prototypes had been found. The prototype was reportedly left behind by former Sony Computer Entertainment CEO Ólafur Jóhann Ólafsson during his time at Advanta. A former Advanta worker (Terry Diebold) acquired the device as part of a lot during Advanta's 2009 bankruptcy auction. The system was later confirmed as operational and the unit plays Super Famicom cartridges as well as the test cartridge that accompanied the unit, although the audio output and CD drive were non-functional.

With the use of a sophisticated security system the player helps the main character, Lea Nichols by telling her where to go, by turning lights on and off, opening doors, entering codes, controlling helper robots, and reading the torrent of files, email, and codes you are given. Not all the e-mail contain helpful information, neither are all the cameras useful, some having fallen objects obscure the view or being otherwise non-functional. The game keeps a log of real world play time with Lea noting how many days long you've kept her waiting since last playing.

Each step in the design and refinement of the system would be recorded as part of an integrated repository. In addition to the artifacts of software development the processes, the various definitions and transformations, would also be recorded in a way that they could be analyzed and also replayed later as needed. The idea was that each step would be a transformation that took into account various non-functional requirements for the implemented system. For example, requirements to use specific programming languages such as Ada or to harden code for real time mission critical fault tolerance.

A proposed mechanism suggests that when DNA Pol III stalls or becomes non-functional, then DNA Pol II is able to be specifically recruited to the replication point and continue replication. There are many different ways that DNA can be damaged, from UV damage to oxidation, so it is logical that there are different types of polymerases to fix these damages. One important role that DNA Pol II is the major polymerase for the repairing of inter-strand cross-links. Interstrand cross-links are caused by chemicals such as nitrogen mustard and psoralen which create cytotoxic lesions.

There is some evidence that even though she rarely wrote about race and racial differences, she may not have ruled out racial primitivity. At this time, Bender was considered an expert in the psychology of African American children because the majority of the children at Bellevue were African American. Although she documented race when conducting her research, she often divided the differences in race into two categories; Functional (significant differences that influence behavior) and Non-functional (differences have no significant impact on behavior). In short, she believed that there were differences in the races, and some made a difference while others did not.

Comparisons with their closest free living cyanobacteria of the genus Synechococcus (having a genome size 3 Mb, with 3300 genes) revealed that chromatophores underwent a drastic genome shrinkage. Chromatophores contained genes that were accountable for photosynthesis but were deficient in genes that could carry out other biosynthetic functions; this observation suggests that these endosymbiotic cells are highly dependent on their hosts for their survival and growth mechanisms. Thus, these chromatophores were found to be non-functional for organelle-specific purposes when compared with mitochondria and plastids. This distinction could have promoted the early evolution of photosynthetic organelles.

The phone was criticized by some reviewers for sub-par GPS performance. Anandtech, reviewing the Epic 4G variant, said, "the phone will take an inordinate amount of time to determine your actual location, and/or it won’t pinpoint your location very accurately." Engadget described the GPS in the Vibrant and Captivate variants as "utterly broken and non-functional … this is a problem for which there's no reasonable explanation why it made it all the way to retail devices." Samsung released an application for the Captivate and Vibrant variants only that resets the phone's GPS settings to factory defaults.

Cicero uses portentum frequently in his treatise De divinatione, where it seems to be a generic word for prodigies.Claude Moussy, "Signa et portenta", in Donum grammaticum: Studies in Latin and Celtic Linguistics in Honour of Hannah Rosén (Peeters, 2002), p. 269 online. The word could also refer in non-technical usage to an unnatural occurrence without specific religious significance; for instance, Pliny calls an Egyptian with a pair of non-functional eyes on the back of his head a portentum.Pliny, Natural History 11.272, Latin text at LacusCurtius; Mary Beagon, Roman Nature: The Thought of Pliny the Elder (Oxford University Press, 1992), p. 146.

Jupiter's inner magnetosphere and radiation belts Jupiter's uniquely harsh radiation environment caused over 20 anomalies over the course of Galileo mission, in addition to the incidents expanded upon below. Despite having exceeded its radiation design limit by at least a factor of three, the spacecraft survived all these anomalies. Work-arounds were found eventually for all of these problems, and Galileo was never rendered entirely non-functional by Jupiter's radiation. The radiation limits for Galileo computers were based on data returned from Pioneers 10 and 11, since much of the design work was underway before the two Voyagers arrived at Jupiter in 1979.

Thoubal has huge potential for fisheries and aquaculture in the Waithou lake and surrounding rivers and water bodies, however excessive encroachment and conversion of water bodies into paddy fields, agricultural lands and homesteads have greatly reduced the area of the lake. A tourist guest house was constructed in the middle of the Waithou lake to boost tourism, however it lies decrepit also non-functional. "G & R Aqua Technologies" , a private fish seed production cum demonstration farm was established in the waithou PatThoubal since 2011 to provide quality fish seeds to the fish farmers and to promote sustainable aquaculture through demonstration.

An autosplenectomy (from 'auto-' self, '-splen-' spleen, '-ectomy' removal) is a negative outcome of disease and occurs when a disease damages the spleen to such an extent that it becomes shrunken and non-functional."Autosplenectomy" with sickle cell anemia, gross at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved September 10, 2011 The spleen is an important immunological organ that acts as a filter for red blood cells, triggers phagocytosis of invaders, and mounts an immunological response when necessary. Lack of a spleen, called asplenia, can occur by autosplenectomy or the surgical counterpart, splenectomy.

Since that time, this non-functional portion has controversially been called "junk DNA". The international Encyclopedia of DNA Elements (ENCODE) project uncovered, by direct biochemical approaches, that at least 80% of human genomic DNA has biochemical activity.. Though this was not necessarily unexpected due to previous decades of research discovering many functional non-coding regions, some scientists criticized the conclusion for conflating biochemical activity with biological function. Estimates for the biologically functional fraction of the human genome based on comparative genomics range between 8 and 15%. However, others have argued against relying solely on estimates from comparative genomics due to its limited scope.

Shared sequences of apparently non-functional DNA are a major line of evidence of common descent."Plagiarized Errors and Molecular Genetics", talkorigins, by Edward E. Max, M.D., Ph.D. Pseudogene sequences appear to accumulate mutations more rapidly than coding sequences due to a loss of selective pressure. This allows for the creation of mutant alleles that incorporate new functions that may be favored by natural selection; thus, pseudogenes can serve as raw material for evolution and can be considered "protogenes". A study published in 2019 shows that new genes (termed de novo gene birth) can be fashioned from non-coding regions.

RACK1 was originally isolated and identified as an intracellular protein receptor for protein kinase C, noting the significant homology to the beta subunit of heterotrimeric G proteins. Later studies established RACK1, and its yeast homolog Asc1, as a core ribosomal protein of the eukaryotic small (40S) ribosomal subunit. Much of the function of Asc1/RACK1 appears to result from its position on the 'head' of the 40S ribosomal subunit. Asc1/RACK1 participates in several aspects of eukaryotic translation and ribosome quality control, including IRES-mediated translation, non-stop decay, non-functional 18S ribosomal RNA decay, and frameshifting.

Starting in 1969, to aid sales and continue the winning formula of the Mustang, a variety of new performance and decorative options became available, including functional (and non-functional) air scoops, cable and pin hood tie downs, and both wing and chin spoilers. Additionally, a variety of performance packages were introduced that included the Mach 1, the Boss 302, and Boss 429. The two Boss models were to homologate the engines for racing. The 1969 Mustang was the last year for the GT option (although it did return on the 3rd Generation Mustang for the 1982 Model Year).

The 1949 Buick Sales brochure stated the following "...four chrome-ringed Venti- Ports on forward fenders (three on all Super models) striking a smart nautical note while serving to ventilate the engine compartment." Air entered from the grille into the engine bay, was pressurized by the radiator fan and exited (partially) through the VentiPorts. However, sometime during the 1949 model year this attribute was discontinued and the VentiPorts became non-functional. When introduced in 1949, there were only 2 model lines; the higher priced Roadmaster had 4 ports per side, the lower series Super had 3.

The 525-series Seibu steam locomotive 532 was manufactured by Orenstein & Koppel in Germany in 1928. It was imported to Japan by the Seibu Railway in 1973, after being used by a Taiwanese sugar factory and used on the Seibu Yamaguchi Line from 1977 to 1984. After their track had been regauged, it came in October 1993 with four wooden coaches of Seibu type 31 (They had been used by Ikasa Railway) to Maruseppu forest park railway. It has been stored in a non-functional state in the engine shed and have not worked on Maruseppu, not even once.

In these species, the male portions of the reproductive system are degenerate and non-functional, or, in many cases, entirely absent. Though the eggs have a diameter of less than 50 µm, they are still very large in comparison with the animals' size. Some species are capable of laying eggs that remain dormant during times of desiccation or low temperatures; these species, however, are also able to produce regular eggs, which hatch in one to four days, when environmental conditions are more favourable. The eggs of all gastrotrichs undergo direct development and hatch into miniature versions of the adult.

This new town centre consisted of pre-cast concrete houses, with millions of small crustacean shells unusually embedded into their external walls, 5 to 10 storey flats, offices, industrial units and service buildings, which often consisted of artistic non-functional characteristics, shops and residential multi-storey car parks, interconnected by ramps and walkways. These made up a deck system of access to shopping and other facilities, employing the Swedish Skarne method of construction. Originally named Killingworth Township, the latter part was quickly dropped through lack of colloquial use. Killingworth is referred to as 'Killy' by many residents of the town and surrounding areas.

The style is primarily associated with an experimental musical movement which arose in Poland in the mid-1950s and flourished through the 1960s. Sonorism emphasizes discovering new types of sounds from traditional instruments, as well as the creation of textures by combining different, often unconventional instrumental sounds in unusual and unique ways. The term sonoristics is used to describe this novel approach, which went beyond merely injecting individual color, quirks, and experimentation. It aimed to establish new structural functions in a composition, such as employing non-functional chords for sonorous effects, and emphasizing the sonic aspect of texts in vocal music .

Null functions have several uses. During software development, null functions with the same names and type signatures as a planned functions are often used as stubs—that is, as non-functional placeholders that allow the incomplete body of code to be compiled and tested prior to completion of all planned features. Null functions, particularly the NOP variety, are also used to provide delays of indeterminate length within wait loops. This is a common strategy in dedicated device controllers that must wait for an external input and have no other tasks to perform while they are waiting.

In 2017, it was announced that all three SpectraTime supplied rubidium atomic clocks on board IRNSS-1A had failed, mirroring similar failures in the European Union's Galileo constellation. The first failure occurred in July 2016, followed soon after by the two other clocks on IRNSS-1A. This rendered the satellite non-functional and required replacement. ISRO reported it had replaced the atomic clocks in the two standby satellites, IRNSS-1H and IRNSS-1I., in June 2017 The subsequent launch of IRNSS-1H, as a replacement for IRNSS-1A, was unsuccessful when PSLV-C39 mission failed on 31 August 2017.

The modern cetacean ear is highly specialised for hearing underwater and detecting certain frequencies, and Ambulocetus seems to share some of these traits. It is unclear if it used its specialised ear for hearing underwater, bone conduction on land, or if the adaptations were entirely non- functional in less aquatic cetaceans. Ambulocetus had a narrow, streamlined body, and heavy, pachyostotic ribs. Ambulocetus is thought to have swum much like modern river otters, alternating beats of the hind limbs while keeping the forelimbs tucked in for most of its propulsive power, as well as undulating the torso and tail.

In evolutionary biology, function is the reason some object or process occurred in a system that evolved through natural selection. That reason is typically that it achieves some result, such as that chlorophyll helps to capture the energy of sunlight in photosynthesis. Hence, the organism that contains it is more likely to survive and reproduce, in other words the function increases the organism's fitness. A characteristic that assists in evolution is called an adaptation; other characteristics may be non-functional spandrels, though these in turn may later be co-opted by evolution to serve new functions.

Functional and non- functional web service testing is done with the help of WSDL parsing and regression testing is performed by identifying the changes made thereafter. Web service regression testing needs can be categories into three different ways, namely, changes in WSDL, changes in code, and selective re-testing of web service operations. To capture above three changes three intermediate forms of WSDL, namely, Difference WSDL (DWSDL), Unit WSDL (UWSDL), and Reduced WSDL (RWSDL), respectively can be used. These intermediate forms of WSDLs are then combined to form Combined WSDL (CWSDL) which is further used for regression testing of the web service.

One of the difficulties frequently encountered in the development of complex systems comes from the superposition of several partially independent functional chains using shared resources (including but not limited to computing resources). The ARCADIA method and the underlying tools are used to identify functional chains, their overlapping scenarios and desired performance, along with their support by the architecture. Starting with the first level of system analysis, they ensure traceability throughout the process definition and check each proposed architectural design against expected performance and constraints. The non- functional properties expected from the system solution are also formalized in 'viewpoints'.

On 9 March 2007, Pakistan President Musharraf declared Chief Justice Chaudhary "non-functional"CJ Suspended, escorted home Dawn – 9 March 2007 and forwarded a reference against him to the Supreme Judicial Council (SJC) of Pakistan. While Justice Bhagwandas should have taken his place as Acting Chief Justice, but his whereabouts remained untraceable and it was said that he was on a foreign tour of India. On 15 March 2007 a petition was filed in the Supreme Court urging the Pakistan Government to declare his whereabouts.Petition in SC on Bhagwandas Dawn – 15 March 2007 He returned home on 23 March.

Ultimately, the park recorded 61,500 visitors, one-third less than the expected maximum capacity, and closed at 9:00 p.m., three hours before its intended closing. At the time, Freedomland was described as having an unfinished quality: one security guard was quoted as saying that the drinking fountains were non- functional, the restrooms were few and far between, the concessionaires were poorly equipped for operation, and many exhibits were not yet painted or decorated. Satellite City and the Chicago Fire were not operational until a few weeks after opening day, the former due to "electrical difficulties".

Infection is considered heavy when there are 10,000-30,000 eggs in one gram of feces. Symptoms of heavier infections with Opisthorchis viverrini may include: diarrhoea, epigastric and upper right quadrant pain, lack of appetite (anorexia), fatigue, yellowing of the eyes and skin (jaundice) and mild fever. These parasites are long-lived and cause heavy chronic infections that may lead to accumulation of fluid in the legs (edema) and in the peritoneal cavity (ascites), enlarged non- functional gall-bladder and also cholangitis, which can lead to periductal fibrosis, cholecystitis and cholelithiasis, obstructive jaundice, hepatomegaly and/or fibrosis of the periportal system.

The pathogenicity of prions and proteins with prion-like domains is hypothesized to arise from their self-templating ability and the resulting exponential growth of amyloid fibrils. The presence of amyloid fibrils in patients with degenerative diseases has been well documented. These amyloid fibrils are seen as the result of pathogenic proteins that self-propagate and form highly stable, non-functional aggregates. While this does not necessarily imply a causal relationship between amyloid and degenerative diseases, the toxicity of certain amyloid forms and the overproduction of amyloid in familial cases of degenerative disorders supports the idea that amyloid formation is generally toxic.

The systems analysis and design (SAD) is the process of developing information systems (IS) that effectively use hardware, software, data, processes, and people to support the company's businesses objectives. It is a process of planning a new business system or replacing an existing system by defining its components or modules to satisfy the specific requirements. System analysis and design can be considered the meta-development activity, which serves to set the stage and bound the problem. SAD can be leveraged to set the correct balance among competing high-level requirements in the functional and non-functional analysis domains.

Most of the shade pavilions to the south of the boardwalk were built in the 2000s and 2010s, and are elevated due to Federal Emergency Management Agency regulations, though there are also some historic pavilions from the 20th century. There are four non-functional historic cast iron fountains as well as newer, functioning steel fountains. The boardwalk's original street furnishings included 170 "twin-arm" street lights similar to those on Fifth Avenue in Manhattan, posted at intervals and at street intersections. Benches that faced the ocean were installed by the J.W. Fiske Ironworks Company, but have also been replaced.

CLD was the least conserved of these regions between D. virilis and D. melanogaster. These conserved parts include: the PER interaction domain, the nuclear localization signal (NLS), cytoplasmic localization domain (CLD), N-terminal end (non- functional), and C-terminal end. TIM is also known to have a basic region, which interacts with the PAS domain of the PER protein, and a central acidic region. There is also a region of unknown function near the N-terminus of the TIM protein that contains a 32 amino acid sequence that, when deleted, causes arrhythmic behavior in the fly.

Attorney General Makhdoom Ali Khan appeared on behalf of the SJC on court notice. The lawyers and opposition parties' leaders and activists gathered in large number outside the Supreme Court building during hearing of the reference. Earlier, Justice Iftikhar Muhammad Chaudhry reached Supreme Court along with his lawyers Barrister Aitzaz Ahsan, Hamid Ali Khan and Justice (Rtd) Tarique Mehmood to appear in the Supreme Judicial Council hearing of presidential reference against him. Barrister Aitzaz Ahsan, leading lawyer assisting the non-functional Chief Justice in the reference, talking to newsmen said that he would raise various objections before the SJC in today's hearing.

He said that he will argue for open trial of Justice Iftikhar Chaudhry in the hearing, as people should know the truth of charges against the non-functional chief justice. Aitzaz Ahsan said that he will also discuss the constitutional status of the Supreme Judicial Council and will argue over whether appointment of the Acting Chief Justice is constitutional or not. Large number of lawyers, political leaders and activists of opposition parties were present before the Supreme Court building when Justice Iftikhar reached the court for hearing of the presidential reference. They were chanting slogans against the government.

The Mercury trains also incorporated roller bearings on their axles, which helped them reach their speed limit of , but also made them harder to stop. Although in service the speed would be restricted to 80 mph, it was reported that the train's top speed was over . It has been said that, "As opposed to [some of his] contemporaries, Dreyfuss was not a stylist: he applied common sense and a scientific approach to design problems." However, it can be seen from his treatment of the driving wheels that Dreyfuss was not above paying close attention to merely stylistic, non-functional details.

Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney. These cysts may begin to develop in utero, in infancy, in childhood, or in adulthood. Cysts are non-functioning tubules filled with fluid pumped into them, which range in size from microscopic to enormous, crushing adjacent normal tubules and eventually rendering them non-functional as well. PKD is caused by abnormal genes that produce a specific abnormal protein; this protein has an adverse effect on tubule development.

A 988 transaction is a transaction described in section 988(c)(1) of the Internal Revenue Code in the United States of America. This transaction occurs when a taxpayer enters into or acquires any debt instrument, forward contract, futures contract, option, or similar financial instrument held in a non- functional currency.26 USCA section 988 The rules for 988 transactions do not apply to any regulated futures contract or non-equity options which would be marked to market under 26 USCA § 125626 USCA § 1256 (1256 contract) if held on the last day of the taxable year.

The clock is never repaired and becomes a local landmark, left in its non-functional state at the behest of the Hill Valley Preservation Society. The broken piece of ledge from Doc Brown's successful attempt to channel lightning from the clock tower is likewise never repaired, as can be seen when Marty returns to 1985 and in 2015, but not in the Alternate 1985. In Marty's original timeline, many of the town square businesses have moved or closed down by 1985. The new businesses which replaced them include a second-hand shop, a yoga studio, and an adult book store.

This is not the actual vehicle or clothing worn during the race by the racer, but a fully officially approved brand-new street-legal product in similar looks. Typically found in helmets, race suits/clothing, and motorcycles, they are coloured in the style of racers, and often carry the highest performance and safety specifications of any street-legal products. These high-performance race-look products termed "Replica", are priced higher and are usually more sought-after than plain colours of the same product. Because of gun ownership restrictions in some locales, gun collectors create non-functional legal replicas of illegal firearms.

A right- hand finger tab to protect the hand while the string is drawn Most modern archers wear a bracer (also known as an arm-guard) to protect the inside of the bow arm from being hit by the string and prevent clothing from catching the bowstring. The bracer does not brace the arm; the word comes from the armoury term "brassard", meaning an armoured sleeve or badge. The Navajo people have developed highly ornamented bracers as non-functional items of adornment. Some archers (nearly all female archers) wear protection on their chests, called chestguards or plastrons.

Purchase price and installation costs were met from the surplus exhibition proceeds, and the organ was installed in the Centre Hall by Lewis and Co. The present case front in walnut with non-functional display pipes was commissioned at this time from John W. Simpson. Simpson was the senior partner of Simpson & Milner Allen, architects of the gallery building. There is an urban myth in Glasgow that the building was accidentally built back-to-front, and the architect jumped from one of the towers in despair upon realising his mistake. In reality, the grand entrance was always intended to face into Kelvingrove Park.

For the 1987 model year, Mercury produced the Mercury 20th Anniversary Cougar as a commemorative edition. Derived from the Cougar LS, the 20th Anniversary Cougar was produced in a near- monochromatic exterior (Cabernet Red with Midnight Smoke moldings); the wheels, all badging, and regular chrome trim were finished in 24 karat gold, with a gold-trimmed C-pillar emblem. The trunk was fitted with a (non- functional) luggage rack. The 20th Anniversary Cougar was fitted with the 5.0 L V8, sport-handling suspension with quad rear shocks (derived from the XR7) and 15-inch alloy wheels (from the Mustang GT, painted gold).

This gender distinction is implemented to enhance safety or ensure proper functionality by preventing unsafe or non-functional configurations from being set up. In terms of mathematical graph theory, an electrical power distribution network made up of plugs and sockets is a directed tree, with the directionality arrows corresponding to the female-to-male transfer of electrical power through each mated connection. This is an example where male and female connectors have been deliberately designed and assigned to physically enforce a safe network topology. In other contexts, such as plumbing, one-way flow is not enforced through connector gender assignment.

These simulations demonstrate that smaller populations fix deleterious mutations by increased genetic drift. This advantage is likely limited by high rates of extinction. Larger populations evolve complexity through mutations that increase expression of particular genes; removal of deleterious alleles does not limit developing more complex genomes in the larger groups and a large number of insertion mutations that resulted in beneficial or non-functional elements within the genome were not required. When deletion mutations occur more frequently, the largest populations have an advantage that suggests larger populations generally have an evolutionary advantage for development of new traits.

In software engineering and systems engineering, a functional requirement defines a function of a system or its component, where a function is described as a specification of behavior between outputs and inputs. Functional requirements may involve calculations, technical details, data manipulation and processing, and other specific functionality that define what a system is supposed to accomplish. Behavioral requirements describe all the cases where the system uses the functional requirements, these are captured in use cases. Functional requirements are supported by non-functional requirements (also known as "quality requirements"), which impose constraints on the design or implementation (such as performance requirements, security, or reliability).

Functional requirements drive the application architecture of a system, while non-functional requirements drive the technical architecture of a system. In some cases a requirements analyst generates use cases after gathering and validating a set of functional requirements. The hierarchy of functional requirements collection and change, broadly speaking, is: user/stakeholder request → analyze → use case → incorporate. Stakeholders make a request; systems engineers attempt to discuss, observe, and understand the aspects of the requirement; use cases, entity relationship diagrams, and other models are built to validate the requirement; and, if documented and approved, the requirement is implemented/incorporated.

This method for studying gene function uses reverse genetics techniques to produce transgenic plants that contain a mechanism for gene silencing through RNA interference. In other studies, using forward genetics techniques such as genetic mapping, it is the analysis of the phenotypes of flowers with structural anomalies that leads to the cloning of the gene of interest. The flowers may possess a non- functional or over expressed allele for the gene being studied. The existence of two supplementary functions, D and E, have also been proposed in addition to the A, B and C functions already discussed.

Catalytic lighters use methanol or methylated spirits as fuel and a thin platinum wire which heats up in the presence of flammable vapours and produces a flame. lighters: the International Standard EN ISO 9994:2002 and the European standard EN 13869:2002. The International Standard establishes non-functional specifications on quality, reliability and safety of lighters and appropriate test procedures. For instance, a lighter should generate flame only through positive action on the part of the user, two or more independent actions by the user, or an actuating force greater than or equal to 15 Newton.

The N-terminal and the transmembrane domains are highly conserved between species. In contrast, the carboxyl-(C-) terminal is found to be diverging between the MRAP isoforms and also between different species. That said, the whole genome of human MRAP shares lower similarity with mouse Mrap, and that is mainly in the N-terminal and transmembrane domain. The alternate splicing of the MRAP mRNA generates 4 isoforms: two functional isoforms which are MRAP-α (173 amino acids); MRAP-β (102 amino acids); non-functional isoforms, isoform 3 (113 amino acids); and isoform 4 (172 amino acids).

"Oh, boy! Are we going to try something dangerous?" when the player saves the game in his presence), and also critical in advancing the plotline. Once Floyd realizes that the ProjCon repair robot (aptly named Achilles) is non-functional, and that the Project is close to completion, he performs the ultimate sacrifice and gives his life to retrieve the vital Miniaturization Card from the Bio-lab (the mutants within kill the player if he tries to get it himself). As Floyd lies dying, the player sings the "Ballad of the Starcrossed Miner" to him (itself an allusion to the earlier Infocom game Starcross).

Fake security camera at the Museum of Bad Art. Fake security cameras (or dummy cameras, simulated cameras, decoy cameras) are non-functional surveillance cameras designed to fool intruders, or anyone who it is supposedly watching. Those cameras are intentionally placed in a noticeable place, so passing people notice them and believe the area to be monitored by CCTV. The cheapest fake security cameras can be recognized by not having real lenses (the "lenses" are just an opaque piece of plastic) Other fake cameras include broken real cameras, motion sensors disguised as cameras, or empty camera housings.

Two non-functional reservoirs (the smaller Lisvane Reservoir is adjoined to Llanishen Reservoir). Llanishen Reservoir forms the end of a Victorian water supply system stretching from the Brecon Beacons to Cardiff and has recently had its CADW listing confirmed. It had been under threat from an American-led commercial development for domestic housing, where the proposed houses would be built around a reduced lake. But the CADW designation plus the Site of Special Scientific Interest for grassland fungi on the embankments of the former reservoir, will make it very difficult for a developer to gain building permission.

TALEN can be used to edit genomes by inducing double-strand breaks (DSB), which cells respond to with repair mechanisms. Non-homologous end joining (NHEJ) directly ligates DNA from either side of a double-strand break where there is very little or no sequence overlap for annealing. This repair mechanism induces errors in the genome via indels (insertion or deletion), or chromosomal rearrangement; any such errors may render the gene products coded at that location non- functional. Because this activity can vary depending on the species, cell type, target gene, and nuclease used, it should be monitored when designing new systems.

The town consists of a NBP bank, a Jamia Mosque and a Government school. It has a small, non-functional dispensary, and the town is in dire need of a hospital. The district Nazim, Syed Sajjad Haider Kirmani, who is a native of the town, also got a sports stadium built just outside it, however since he has died, the project remains incomplete and is being used for anything but sports. The Jamia Mosque was a historical building built by Sher Shah Suri, but it was in bad condition and beautifully rebuilt by the Auqaf Department.

PyMusique was written by Travis Watkins, Cody Brocious, and Jon Lech Johansen for the purpose of allowing downloading songs from the iTunes Music Store before DRM was applied to them from a Mac, Linux, or Windows computer. It was first released via Johansen's website on March 18, 2005. Although the iTunes Music Store's method of applying FairPlay DRM to the songs was widely known, PyMusique was the first program to exploit a loophole in the system, allowing users to download songs without the DRM restriction. On March 22, 2005, Apple released an update that rendered PyMusique non-functional.

The homeless population eligible cannot enjoy the shelters at night as that is their time of employment, thus defeating the purpose of the shelter. Furthermore, the data collected from survey analysis of homeless shelters showed the following: the shelters are majority male consisting of wage workers, taxi and rickshaw drivers, and tourists. The lack of women in shelters suggests that either women don't find shelters helpful or that there is low tendency for families to seek shelters. The shelters have inadequate bedding, water, bathrooms, tools, gas for cooking, rodent control, activity space and non-functional first aid.

Lepidurus apus has an unusual life-cycle: it is able to produce microscopic cysts that can lie dormant for years at a time through extreme conditions, letting it survive in areas with vastly different climates such as Morocco and Denmark. These "resting eggs" are so drought resistant there is a record of hatching after being kept dry for 28 years. The species is hermaphroditic; no males are found in the New Zealand subspecies viridius, but in Italy there are males that are non-functional. Different subspecies of Lepidurus apus have different methods of fertilisation, some by a male, some by hermaphroditic individuals.

During Gay Pride 2008 one phase of the power failed in the club leaving limited disco lighting in operation and no music playing for about 20 minutes. Staff at the club managed to bring most of the power back on-line, however several sets of disco lights and bar lights were non-functional on one of the clubs busiest nights of the year. The power failure was caused by a failure of the main supply to the building. During New Year's Eve 2008 a small fire broke out on stage shortly after midnight which was caused by a mis-firing show pyrotechnic.

Thus it can be understood that mutations in PRPF31 can cause alternative, potentially non-functional, forms of the rhodopsin protein. It was shown that expression of these mutant PRPF31 proteins significantly reduced rhodopsin expression in cultured retinal cells and induced apoptosis of retinal cells, establishing a link between mutations in proteins involved in pre-mRNA splicing and the expression of a critical retina-specific gene, rhodopsin. This shows that non-rhodopsin mutations may also be critical in presentation of retinal degenerative disorders. It suggests a mechanism for retinal degeneration caused by non-retinal-specific genes, such as PRPF31 mutations.

Insertional inactivation focuses on suppressing the expression of a gene by disrupting its sequence with an insertion. When additional nucleotides are inserted near or into a locus, the locus can suffer a frameshift mutation that could prevent it from being properly expressed into polypeptide chain. Transposon-based Insertional inactivation is considered for medical research from suppression of antibiotic resistance in bacteria to the treatment of genetic diseases. In the treatment of genetic diseases, the insertion of a transposon into deleterious gene locus of organism's genome would misalign the locus sequence, truncating any harmful proteins formed and rendering them non-functional.

A TV series showcased the complete build for the 45th Anniversary Tour replica car, built to the specifications for the television show. Dean Jeffries, the Monkeemobile's original designer and fabricator, provides direction and commentary for the car's refurbishment. This was among his last projects before his death. Unlike some other "copies" that lack many of the details of the original, the 1967 Pontiac GTO 4-speed "donor car" was professionally transformed to a concours grade show car with exacting detail, from the GM paint code "R" to the (non-functional) gold plated supercharger and correct Cragar wheels.

Returning spacecraft (including all potentially manned craft) have to find a way of slowing down as much as possible while still in higher atmospheric layers and avoid hitting the ground (lithobraking) or burning up. For many orbital space flights, initial deceleration is provided by the retrofiring of the craft's rocket engines, perturbing the orbit (by lowering perigee down into the atmosphere) onto a suborbital trajectory. Many spacecraft in low-Earth orbit (e.g., nanosatellites or spacecraft that have run out of station keeping fuel or are otherwise non-functional) solve the problem of deceleration from orbital speeds through using atmospheric drag (aerobraking) to provide initial deceleration.

While impractical for wearing as an every day adornment, the vibrant color scheme forced the wearer and observer to imagine and redefine how one moves through space. In 1989, the School of Fine Arts Gallery of her alma mater in Indiana hosted a solo show Marjorie Schick: A Retrospective, covering the first 25 years of her career. It featured over a hundred works, displayed without the use of models or mannequins, either protruding from walls or hanging from ceilings. The display showed that the works were non-functional as simple adornments and in a unique way were "unfinished" in the absence of the body of the wearer.

Portability testing is the process of determining the degree of ease or difficulty to which a software component or application can be effectively and efficiently transferred from one hardware, software or other operational or usage environment to another. The test results, defined by the individual needs of the system, are some measurement of how easily the component or application will be to integrate into the environment and these results will then be compared to the software system's non-functional requirement of portability for correctness. The levels of correctness are usually measured by the cost to adapt the software to the new environment compared to the cost of redevelopment.

After successful infection, the leaf blade is colonized and sporulation will occur through the stomata. One lesion produces 4–6 spore crops over a 3–5 month period releasing 300–400,000 spores. While the predominant hypothesis is that H. vastatrix is heteroecious, completing its life cycle on an alternate host plant which has not yet been found, an alternative hypothesis is that H. vastatrix actually represents an early-diverging autoecious rust, in which the teliospores are non-functional and vestigial, and the sexual life cycle is completed by the urediniospores. Hidden meiosis and sexual reproduction (cryptosexuality) has been found within the generally asexual urediniospores.

Despite its benefits, this technique decreases the yield of fabrication since any defective chip in the package will result in a non-functional packaged integrated circuit, even if all other modules in that same package are functional. SiP technology is primarily being driven by market trends in wearables, mobile devices and the internet of things. As the internet of things becomes more of a reality and less of a vision, there is innovation going on at the system on a chip and SiP level so that microelectromechanical (MEMS) sensors can be integrated on a separate die and control the connectivity.By Ed Sperling, Semiconductor Engineering. “Why Packaging Matters.” November 19, 2015.

This leads to the acceptance of incorrect aa-tRNAs, causing the ribosome to synthesize proteins with wrong amino acids placed throughout (roughly every 1 in 500). The non-functional, mistranslated proteins misfold and aggregate, eventually leading to death of the bacterium. A secondary mechanism has been proposed based on crystal structures of gentamicin in a secondary binding site at helix 69 of the 23S rRNA, which interacts with helix 44 and proteins that recognize stop codons. At this secondary site, gentamicin is believed to preclude interactions of the ribosome with ribosome recycling factors, causing the two subunits of the ribosome to stay complexed even after translation completes.

Born in Los Angeles to Mexican immigrant parents, De Larios grew up in downtown Los Angeles near Silver Lake, where she was surrounded by Mexican and Nisei Japanese immigrants. This diverse community, as well as her childhood trips to the Museo Nacional de Antropología in Mexico City, inspired her to create artwork that blended influences from ancient American and Japanese ceramics. She studied with potters Otto and Vivika Heino and Susan Peterson at the University of Southern California. Her professors exposed her to the work of radical ceramic artists, notably Peter Voulkos, whose abstract work encouraged her to explore non- functional forms in clay.

Fladmark's analysis of the assemblage led him to believe that the creation of argillite pieces for the purpose of trade followed its use within the Haida community as a pipestone. The elbow pipes Fladmark discovered at the site may predate the generally accepted 1820 start date for the production of argillite as a saleable commodity. These elbow pipes have little to no decoration and seemingly serve a utilitarian purpose only, characteristics which separate them from the later non-functional panel pipes, and other solely aesthetic argillite pieces. Also, Fladmark notes the discovery of a labret in the archaeological record which appears to be made from argillite.

The BattleDromes, Transporters, and CodeScanners can analyze and/or modify this code for matches, transport, or creation of virtual cards. When the players are in Chaotic/Perim they exist simultaneously on Earth. When a Chaotic player leaves Chaotic they become one person again and the Earth version of the player gains the memories of anything they experienced in the Chaotic/Perim world. This is awkward the first time they transport, as their online deck is blocked so that their Chaotic self can use it and their scanner becomes non-functional, causing many people to believe they have broke their scanners until they are re-united with their Chaotic self.

The first concern of the firefighters was to ensure that the gasoline running down the drainage system did not pose an explosion hazard to their firefighting efforts. Unfortunately the valves that should have been used to divert the drainage outfall to a hazardous materials sump were corroded and non-functional, and the gasoline went into a nearby lake. Firefighting at the site in the tunnel began at 1:30 am once the potentially explosive atmosphere at the lake was under control. However, the heat of the fire had seriously affected the integrity of the tunnel firemain, and the water pressure was insufficient to support a hose stream.

This is because kernel execution either halted or the program counter resumed execution from somewhere in an endless, and—usually—non-functional loop. This would be akin to either experiencing amnesia (kernel execution failure) or being trapped in a closed maze that always returns to the starting point (closed loops). The principle of least privilege demonstrated by privilege rings for the Intel x86 If execution picks up after the crash by loading and running trojan code, the author of the trojan code can usurp control of all processes. The principle of least privilege forces code to run with the lowest privilege/permission level possible.

The four heavy chain diseases are exceedingly rare conditions associated with the production, circulation in blood, and often presence in urine of a free clonal heavy chain with no detected clonal light chains. The heavy chain is non- functional and altered by having deletions, insertions, and point mutations due to somatic mutations in their respective coding genes. Beyond this commonality, however, these diseases have very different clinical differences. Furthermore, each of the heavy chain diseases appears to be due to rare variants of lymphoma and therefore is sometimes regarded as a B cell dyscrasia However, heavy chain diseases are still often classified with plasma cell dyscrasias.

Wooden mines had been used by the Russians in 1939, before the appearance of metal detectors, in order to save steel. Some, like the PP Mi-D mine, continued to be used into the 1980s as they were easy to make and hard to detect. Wood has the disadvantage of rotting and splitting, rendering the mine non-functional after a comparatively short time in the ground (or the advantage, in that the mine can be considered self-disabling, and will be less likely to cause unintended injuries years later). Mines manufactured after the 1950s generally use plastic casings to hinder detection by electronic mine detectors.

Oftentimes, a portion of architecture is done during the conceptualization of an application, system, or network and may appear in the non-functional sections of requirement documentation. Canonically, design is not specified in requirements, but is rather driven by them. The process of defining an architecture may involve heuristics, acquired by the architect or architectural team through experience within the domain. As with design, architecture often evolves through a series of iterations, and just as the wisdom of a high level design is often tested when low level design and implementation occurs, the wisdom of an architecture is tested during the specification of a high level design.

The size of the mandibular foramen can determine the size of the fat pad, and that of Ambulocetus is larger than that of Pakicetus and terrestrial mammals, but is smaller than later archaeocetes and toothed whales. Nonetheless, a lot of the change to the external auditory apparatus occurred between Pakicetus and Ambulocetus. These early archaeocetes may have developed such an external ear to either: better hear underwater; facilitate bone conduction of vibrations on dry land as some low-lying terrestrial creatures do (namely turtles and subterranean mole rats); or it was non-functional, and the malleus and jawbone (which are connected in the embryo stage of mammals) happened to stop separating.

Alnus serrulata has unisexual flowers and is monoecious. Shown here: maturing male flower catkins on the right, last year's female catkins on the left. Ilex aquifolium is dioecious: (above) shoot with flowers from male plant; (top right) male flower enlarged, showing stamens with pollen and reduced, sterile stigma; (below) shoot with flowers from female plant; (lower right) female flower enlarged, showing stigma and reduced, sterile stamens (staminodes) with no pollen A "perfect" flower has both stamens and carpels, and may be described as "bisexual" or "hermaphroditic". A "unisexual" flower is one in which either the stamens or the carpels are missing, vestigial or otherwise non-functional.

In another study of TLR11 in mice, exposure of human uropathogenic E. coli bacteria to mouse cells expressing TLR11 resulted in NF-kappa B activation. While the bladders from both wild-type and knockout mice were almost equally infected, the kidneys of the mice without TLR11 had 10,000 times more bacteria and showed a greater inflammatory response than the normal mouse kidneys. TLR11 appears to recognize a pattern on uropathogenic E. coli and can prevent ascending infection. It is important to note that mice as a species do not grapple with urinary tract infections like humans do unless some part of their TLR11 immune response is made non-functional.

When this mutant subunit is expressed in cells with wild-type α and β subunits it produces non-functional receptors. Since wild-type α and β subunits expressed alone are able to produce GABA inducible current this indicates that the mutation either prevents both coassembly of the mutant and wild-type subunits but also coassembly of the wild-type α and β subunits or prevents proper trafficking of the formed receptor to the membrane. Fusion of GFP onto this mutated subunit has indicated that it is localized to the endoplasmic reticulum instead of the cell membrane. As with other known GEFS+ type 3 mutation, Q351X likely results in neuronal hyperexcitability.

Unlike other Linux compatibility layer mobile apps, UserLAnd does not require a root account. UserLAnd's ability to function without root directories, also known as "rooting," avoids "bricking" or the non-functionality of the mobile device while the Linux program is in use, which in addition to making the mobile device non-functional may void the device's warranty. Furthermore, the requirement of programs other than UserLAnd to "root" your mobile device has proven a formidable challenge for inexperienced Linux users. A prior application, GNURoot Debian, attempted to similarly run Linux programs on mobile devices, but it has ceased to be maintained and, therefore, is no longer operational.

A common issue in previous versions of Windows was that users frequently suffered from DLL hell, where more than one version of the same dynamically linked library (DLL) was installed on the computer. As software relies on DLLs, using the wrong version could result in non-functional applications, or worse. Windows 98 Second Edition and Windows 2000 partially solved this problem for native code by introducing side-by-side component sharing and DLL/COM redirection. These operating systems allowed loading a private version of the DLL if it was placed in the application's folder by the developer, instead of the system directory and must be registered properly with the system.

The windows were intended to offset the significant blind spots created by wide C-pillars that were characteristic of many American cars produced at this time. In an age of decreasing dimensions and increasingly common use of non- opening rear side windows on 2-door models, a variety of shapes of rear windows may have helped passengers there to feel somewhat less claustrophobic. These windows were usually non-functional; however, in the case of the AMC Matador coupe NASCAR racers, the small windows that came with the Barcelona II trim package actually helped to clean up the aerodynamics when such windows were open to the wind under racing conditions.

However, women with complete androgen insensitivity syndrome (CAIS), who have a 46,XY ("male") genotype and testes but a defect in the AR such that it is non-functional, are a challenge to this notion. They are completely insensitive to the AR-mediated effects of androgens like testosterone, and show a perfectly female phenotype despite having testosterone levels in the high end of the normal male range. These women have little or no sebum production, incidence of acne, or body hair growth (including in the pubic and axillary areas). Moreover, CAIS women have lean body mass that is normal for females but is of course greatly reduced relative to males.

The loss of this enzyme activity is responsible for the inability of guinea pigs to enzymatically synthesize vitamin C. Both these events happened independently of the loss in the haplorrhini suborder of primates, including humans. The remnant of this non- functional gene with many mutations is, however, still present in the genomes of guinea pigs and humans. It is unknown if remains of the gene exist in the bats who lack GULO activity. The function of GULO appears to have been lost several times, and possibly re-acquired, in several lines of passerine birds, where ability to make vitamin C varies from species to species.

By providing information on mechanism of action, epitope mapping is a critical component in therapeutic monoclonal antibody (mAb) development. Epitope mapping can reveal how a mAb exerts its functional effects - for instance, by blocking the binding of a ligand or by trapping a protein in a non-functional state. Many therapeutic mAbs target conformational epitopes that are only present when the protein is in its native (properly folded) state, which can make epitope mapping challenging. Epitope mapping has been crucial to the development of vaccines against prevalent or deadly viral pathogens, such as chikungunya, dengue, Ebola, and Zika viruses, by determining the antigenic elements (epitopes) that confer long-lasting immunization effects.

Although it is double-breasted, since the 1870s, the dress coat no longer fastens in the front. As a result, although there are two rows of buttons, these are all non-functional, serving only a decorative function. As part of modern white tie, either a black dress coat is worn with a stiff detachable white wing-collar dress shirt, with a plain starched pique bib, and single cuffs fastened with cufflinks; a matching white marcella cotton bowtie and white waistcoat; black trousers; and black patent leather pumps with stockings. Additionally, a top hat, silk dress scarf, and white dress gloves are also seen as acceptable.

Chief Justice Iftikhar Chaudhry's reaction was not known as since his "suspension" or being made "non-functional" he had remained incommunicado. After his meeting with President Musharraf, he remained inside the presidential office for a few hours, and was later prevented from going to the Supreme Court by the security officials. He was later placed under unofficial house arrest and media or anyone from the outside world was not allowed to approach him. Soon after the oath taking ceremony, the SJC went into a session and decided to call on Chief Justice Iftikhar Muhammad Chaudhry on 13 March to answer the allegations of misconduct levelled against him.

The RNAi pathway in insects is very similar to that of other animals; Dicer-2 cleaves viral RNA and loads it onto the RISC complex where one strand serves as a template for the production of RNAi products and the other is degraded. Insects with mutations leading to non-functional components of their RNAi pathway show increased viral loads for viruses they carry or increased susceptibility to viruses for which they are hosts. Similarly to humans, insect viruses have evolved mechanisms to avoid the RNAi pathway. As an example, Drosophila C virus encodes for protein 1A which binds to dsRNA thus protecting it from dicer cleavage as well as RISC loading.

1970 Plymouth Road Runner The 1970 model year brought new front and rear end looks to the basic 1968 body, and it would prove to be another success. Updates included a new grille, a cloth & vinyl bench seat, hood, front fenders, quarter panels, single-piston Kelsey-Hayes disc brakes (improved from the rather small-rotor Bendix 4 piston calipers of '68 - '69 ), and even non-functional scoops in the rear quarters. The design and functionality of the Air Grabber option was changed. A switch below the dash actuated a vacuum servo to slowly raise the forward-facing scoop, exposing shark-like teeth on either side.

Severe combined immunodeficiency (SCID) is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in differing clinical presentations. SCID involves defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" (B cells and T cells) of the adaptive immune system are impaired due to a defect in one of several possible genes. SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID.

Each portion (the functional and the non-functional) of the software project requires work effort to develop, which is proportional to their software sizes. Software development organizations can use their correlations between function points and their work effort, and between SNAP points and their work effort, to help forecast their software development costs and schedules and to audit projects to determine how well funding was spent and schedules were managed SNAP recognizes four categories and 14 subcategories of non-functionality. These are in the below table from the APM. ;1. Data Operations 1.1.Data Entry Validations 1.2.Logical and Mathematical Operations 1.3.Data Formatting 1.4.

The Cys215 residue is essential for the enzymatic activity of PTP1B and similar cysteine residues are required for the activity of other members of the Class I PTP family. The thiolate anion form is needed for nucleophilic activity but it is susceptible to oxidation by reactive oxygen species (ROS) in the cell which would render the enzyme non-functional. This cysteine residue has been shown to oxidize under increased cellular concentrations of hydrogen peroxide (H2O2), produced in response to EGF and insulin signaling. The thiolate is oxidized to a sulfenic acid, which is converted to a sulfenyl amide after reacting with the adjacent Ser216 residue.

When the river was drained in 2010, the Gullywhumper was lovingly restored to its 1955 appearance, with some sources claiming that the original had been scrapped and replaced by a replica. A former Mike Fink Keel Boat from the Magic Kingdom's version of the attraction today sits as a non-functional prop on the banks of Tom Sawyer Island. Regarding its status at Disneyland Paris, the attraction does not appear anymore on the Park Guides or Maps. After a short opening during the summer 2010, the attraction is currently closed and hidden from the view of visitors with 'Danger: Bear Cave' signs surrounding it.

Copy-neutral LOH is thus called because no net change in the copy number occurs in the affected individual. Possible causes for copy-neutral LOH include acquired uniparental disomy (UPD) and gene conversion. In UPD, a person receives two copies of a chromosome, or part of a chromosome, from one parent and no copies from the other parent due to errors in meiosis I or meiosis II. This acquired homozygosity could lead to development of cancer if the individual inherited a non-functional allele of a tumor suppressor gene. In tumor cells copy-neutral LOH can be biologically equivalent to the second hit in the Knudson hypothesis.

Heterozygous mutation of the GRN gene leading to progranulin haploinsufficiency causes Frontotemporal Dementia. __These mutations include frameshift, splice site, nonsense signal peptide, Kozak sequence disruptions and missense mutations, which result in either nonsense-mediated decay or the production of non-functional protein. Patients with GRN caused FTD (GRN-FTD) exhibit asymmetric brain atrophy, although age of onset, disease progression and clinical symptoms vary, suggesting that other genetic or environmental factors may be involved in disease expression. Pathological indicators include cytosolic ubiquitin deposits enriched in hyperphosphorylated TAR DNA Binding Protein (TDP-43), autophagy-related protein aggregates, ubiquitin-binding protein p62, lentiform intranuclear inclusions, dystrophic neurites and inflammation.

Two examples of these types of compounds are Methylene blue and Naphthoquinone. Clinical trials performed in Burkina Faso have revealed mixed results when treating malaria with Naphthoquinones In cells exposed to high levels of oxidative stress, like red blood cells, up to 10% of the glucose consumption may be directed to the pentose phosphate pathway (PPP) for production of the NADPH needed for this reaction. In the case of erythrocytes, if the PPP is non-functional, then the oxidative stress in the cell will lead to cell lysis and anemia. Lupus is an autoimmune disorder in which patients produce an elevated quantity of antibodies that attack DNA and other cell components.

In computer programming and software design, code refactoring is the process of restructuring existing computer code—changing the factoring—without changing its external behavior. Refactoring is intended to improve the design, structure, and/or implementation of the software (its non-functional attributes), while preserving its functionality. Potential advantages of refactoring may include improved code readability and reduced complexity; these can improve the source codes maintainability and create a simpler, cleaner, or more expressive internal architecture or object model to improve extensibility. Another potential goal for refactoring is improved performance; software engineers face an ongoing challenge to write programs that perform faster or use less memory.

The genetic mutation that leads to Becker muscular dystrophy is an in-frame deletion. This means that, out of the 79 exons that code for dystrophin, one or several in the middle may be removed, without affecting the exons that follow the deletion. This allows for a shorter-than-normal dystrophin protein that maintains a degree of functionality. In Duchenne muscular dystrophy, the genetic mutation is out-of- frame. Out-of-frame mutations cause a premature stop in protein generation - the ribosome is unable to “read” the RNA past the point of initial error - leading to a severely shortened and completely non-functional dystrophin protein.

While the LTD received an egg-crate grille design, the Marquis was given a vertically-oriented grille (similar to the 1978 Marquis and the 1980 Cougar XR7) and parking lamps similar to the 1975-1978 Marquis; hidden headlamps were abandoned. In line with the previous generation, the Marquis received full-width taillamps (bordering the license plate). In a feature adopted from the Mark series, the Marquis was styled with (non- functional) fender louvers behind the front wheels (and vents in the front bumper). Ford, Lincoln, and Mercury each received its own dashboard design; Mercury received an instrument panel with square white-face instrument bezels.

Pathogenic mutations of this gene are responsible for X-linked retinoschisis an early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. Female carriers of the RS1 mutation do not show symptoms of X-linked juvenile retinoschisis, except in rare cases where the non-functional protein is expressed due to anomalous X-chromosome inactivation. In young males who carry a gene mutation, the disease presents itself as retinal cavities, splitting of inner retinal layers (also known as foveal schisis), and defective synapse activity. Retinas that lack mature retinoshisin develop these characteristics in up to 1 in 5,000 males.

The town has two hospitals: Nchanga North General Hospital (Government-owned, bed capacity 283) and Nchanga South Hospital (privately owned by the KCM (Konkola Copper Mines Plc), bed capacity about 100). The town also has sports amenities that were previously managed and maintained by the subsidiary of Zambia Consolidated Copper Mines Limited, Nchanga Division; These include Crickets Club, Swimming pool (non functional), Rugby Club, Golf Club, tennis and Cinema (now converted into a church). These clubs are all located along Fern Avenue, aside from the golf course. There are several lodges in Chingola and one notable Hotel, Protea by Marriott Chingola located along Kabundi road.

When writing a class using the Singleton pattern, only one instance of that class can exist at a time. As a result, the class must not be allowed to make a clone. To prevent this, one can override the `clone()` method using the following code: public Object clone() throws CloneNotSupportedException { throw new CloneNotSupportedException(); } This is only necessary if a superclass implements a public `clone()` method, or to prevent a subclass from using this class's `clone()` method to obtain a copy. Classes don't usually inherit a public `clone()` method because `Object` doesn't have a public `clone()` method, so it is usually unnecessary to explicitly implement a non-functional `clone()` method.

Spontaneous mutations often occur which can cause various changes in the genome. Mutations can either change the identity of one or more nucleotides, or result in the addition or deletion of one or more nucleotide bases. Such changes can lead to a frameshift mutation, causing the entire code to be read in a different order from the original, often resulting in a protein becoming non-functional. A mutation in a promoter region, enhancer region or transcription factor binding region can also result in either a loss of function, or an up or downregulation in the transcription of the gene targeted by these regulatory elements.

A recessive mutation in this E gene truncates the protein, producing a non-functional receptor incapable of directing eumelanin deposition in the fur. Among dogs, this mutation is unique to yellow Labrador Retrievers and Golden Retrievers and is thought to have arisen in the retriever population before these individual breeds became distinct. The exact mutation has also been found to underlie the colouration of white coyotes found around Newfoundland, having apparently passed into that population through interbreeding with a Golden Retriever. As with the B locus, presence of a single copy of the functional receptor gene ('E') will result in the dominant phenotype: presence of eumelanin in the fur.

For reassortment, some segmented viruses package their genomes into multiple virions, which produces genomes that are random mixtures of parents, whereas for those that are packaged into a single virion, typically individual segments are swapped. Both forms of recombination can only occur if more than one virus is present in a cell, and the more alleles are present, the more likely recombination is to occur. A key difference between copy choice recombination and reassortment is that copy choice recombination can occur anywhere in a genome, whereas reassortment swaps fully-replicated segments. Therefore, copy choice recombination can produce non-functional viral proteins whereas reassortment cannot.

These medications have the opposite action on the GnRH receptor but paradoxically have the same therapeutic effects. GnRH agonists, such as leuprorelin (Lupron), goserelin (Zoladex), and buserelin (Suprefact), are GnRH receptor superagonists, and work by producing profound desensitization of the GnRH receptor such that the receptor becomes non- functional. This occurs because GnRH is normally released in pulses, but GnRH agonists are continuously present, and this results in excessive downregulation of the receptor and ultimately a complete loss of function. At the initiation of treatment, GnRH agonists are associated with a "flare" effect on hormone levels due to acute overstimulation of the GnRH receptor.

Some of the problems using this thermal process of coating and curing includes: Speed of printing limited by length and speed of pin chain conveyors, high energy costs for gas ovens, and also the can coatings becoming non-functional, when they are overheated in the oven due to slow speed or stoppages. Also, the use of lubricants on the pin chains is kept to a minimum to prevent it from getting into the can. Because of this, pin chains "wear excessively and break frequently". Before it can even be repaired, 20 minutes need to be spent to wait for the oven to cool down enough.

This articulation point of vertical tower against the horizontal smoothness provides an impression of disrupting the elasticity. Rounded façades with mainly purely decorative non-functional elements are similar to the Amsterdam School style, but Aalbers was a follower of the International style or modernist architecture that believed form should simply follow function and eschew such decoration. One pioneer of modernist architecture, Le Corbusier, famous for facades of open space, inspired Aalbers in his designs for the interior of the DENIS bank. The ground floor contains a staircase with glass window leading to a public place, while the second floor is used as offices with large terraces facing Naripan street.

It has been reported that the temperature set point adjustment on thermostats in many office buildings in the United States is non-functional, installed to give tenants' employees a similar illusion of control. In some cases they act as input devices to a central control computer but in others they serve no purpose other than to keep employees contented. A common implementation in buildings with an HVAC central control computer is to allow the thermostats to provide a graded level of control. Temperatures in such a system are governed by the central controller's settings, which are typically set by the building maintenance staff or HVAC engineers.

Purely functional data structures are often represented in a different way than their imperative counterparts.Purely functional data structures by Chris Okasaki, Cambridge University Press, 1998, For example, array with constant- time access and update is a basic component of most imperative languages and many imperative data-structures, such as hash table and binary heap, are based on arrays. Arrays can be replaced by map or random access list, which admits purely functional implementation, but the access and update time is logarithmic. Therefore, purely functional data structures can be used in languages which are non-functional, but they may not be the most efficient tool available, especially if persistency is not required.

There may be differences of opinion as to what are > questions of jurisdiction but, in my lexicon, they rise above and are > different from errors of law, whether involving statutory construction or > evidentiary matters or other matters. It is now unquestioned that privative > clauses may, when properly framed, effectively oust judicial review on > questions of law and, indeed, on other issues not touching jurisdiction. > However, ... s. 96 is in the British North America Act and ... it would make > a mockery of it to treat it in non-functional formal terms as a mere > appointing power...Ibid at 236 This judgment stood in contrast to CUPE v.

A software requirements specification (SRS) is a description of a software system to be developed. It is modeled after business requirements specification (CONOPS), also known as a stakeholder requirements specification (StRS). The software requirements specification lays out functional and non- functional requirements, and it may include a set of use cases that describe user interactions that the software must provide to the user for perfect interaction. Software requirements specification establishes the basis for an agreement between customers and contractors or suppliers on how the software product should function (in a market-driven project, these roles may be played by the marketing and development divisions).

The main Far Cry games are first-person shooters (FPS) with action-adventure elements. Whereas the first Far Cry and its spinoffs were typical FPS with discrete levels, Far Cry 2 and the subsequent games have adapted an open world-style of gameplay, with main story and side missions and optional quests to complete. There are minimal narrative elements or chronology between the games. Instead, the Far Cry games have generally shared the theme of taking the player to "a lawless frontier" where "values and laws of today are non-functional", along with elements of having to survive in the wilderness including hunting and crafting.

Possibly the most obvious identifying feature of the species is the characteristic pelvic fin, of which the first ray is modified into a laterally compressed club-like structure that overlaps the much reduced ventral spine at the base of the fin. Other distinguishing features include 66 to 73 lateral line scales and a total of 35 vertebrae. The swim bladder morphology is also very distinct in the Club-foot whiting, with a structure very different from the rest of the Sillaginidae. It is a very flat, non functional structure that sits just behind the axis vertebra and abruptly narrows to a fine point terminating at the 9th abdominal vertebrae.

All songs are scored for a four- part unaccompanied mixed chorus, except for Quand j'ai ouy le tambourin sonner, which is set for alto soloist and alto-tenor-bass. His choice of Renaissance song techniques and use of romantic texts from the past was a neoclassical trend at the time of composition. The Renaissance devices he integrated into this twentieth-century composition includes the modality and equal-voice polyphony. Each piece is in ternary form, the beginning of each is repeated at the end and features Debussy's signature use of non-functional dominant seventh chords and half-diminished seventh chords (functioning as an incomplete dominant ninth).

Changes in DNA caused by mutation in a coding region of DNA can cause errors in protein sequence that may result in partially or completely non-functional proteins. Each cell, in order to function correctly, depends on thousands of proteins to function in the right places at the right times. When a mutation alters a protein that plays a critical role in the body, a medical condition can result. One study on the comparison of genes between different species of Drosophila suggests that if a mutation does change a protein, the mutation will most likely be harmful, with an estimated 70 percent of amino acid polymorphisms having damaging effects, and the remainder being either neutral or weakly beneficial.

The phylogenetic relationships in the genus Sarcoscypha were analyzed by Francis Harrington in the late 1990s. The cladistic analysis combined comparison of sequences from the internal transcribed spacer in the non-functional RNA with fifteen traditional morphological characters, such as spore features, fruit body shape, and degree of hair curliness. Based on this analysis, S. occidentalis is part of a clade of evolutionarily related taxa that includes the species S. dudleyi, S. emarginata, S. hosoyae, S. korfiana and S. mesocyatha. All of these species contain large oil droplets in their spores, in contrast to the other major clade of Sarcoscypha (containing the type species S. coccinea), characterized by having smaller, more numerous droplets.

After they radio-contact robot John and learn of the men's fevers, they instruct John to immediately give life-saving medicine to the men. Ivan and Allan soon recover, just as flows of molten hot mud surround them. Desperately, Ivan has John carry them safely across the steaming mud, but John over-heats and slows from the added weight on him, so John attempts to forcibly remove them with his claw and painfully injures Allan. The hovercar group suddenly arrives just in time to rescue the men and quickly leave the area, but robot John, now non-functional from the intense heat, slowly falls into the now deep molten flow and perishes.

Explorers from either surface do not notice the transition until after it is already made, causing quite a shock for most. The Hollow World was originally discovered by Ka the Preserver, an ancient Immortal who began life as a giant carnosaur, who after finding it, decided to use the inner surface of the world as a refuge and preserve for creatures that were on the verge of becoming extinct in the ever-changing outer world. Characters from the surface world are severely limited by the magic used by the Immortals to preserve the stability of the various cultures. The requirements to learn magic are much higher in the Hollow World, and many spells are non-functional or unavailable.

Enzyme therapy is being actively studied for genetic metabolic diseases where an enzyme is over-expressed, under-expressed, defective, or not at all there. In the case of under-expression or expression of a defective enzyme, an active form of the enzyme is introduced in the body to compensate for the deficit. On the other hand, an enzymatic over-expression may be counteracted by introduction of a competing non-functional enzyme; that is, an enzyme which metabolizes the substrate into non-active products. When placed within an artificial cell, enzymes can carry out their function for a much longer period compared to free enzymes and can be further optimized by polymer conjugation.

The robots went into the plants and took pictures to help assess the situation, but they couldn't perform the full range of tasks usually carried out by human workers. The Fukushima disaster illustrated that robots lacked sufficient dexterity and robustness to perform critical tasks. In response to this shortcoming, a series of competitions were hosted by DARPA to accelerate the development of humanoid robots that could supplement relief efforts. Eventually a wide variety of specially designed robots were employed (leading to a robotics boom in the region), but as of early 2016 three of them had promptly become non-functional due to the intensity of the radioactivity; one was destroyed within a day.

In one 2006 study, ewes whose primary olfactory systems were incapacitated by nasal irrigation with zinc-sulfate procaine solution displayed rejection behaviors toward foreign lambs to the same degree as did control ewes. Ewes whose vomeronasal organs were rendered non-functional by electro-cauterization failed to reject alien lambs at the udder, and were noted to perform more maternal flehmens, a behavior related to vomeronasal activity. The lack of vomeronasal function was confirmed based on the formation of complete mucosal scarring over both oral and nasal openings of the nasoincisive duct. This suggests that the vomeronasal organ plays an active role in maternal identification of the lamb at the udder Booth, K., 2006.

In cases of spine duplication, prophylactic surgery can be done to remove one duplicated spine, although it depends on the severity of duplication. In cases of malformation of the neural cord such as myelomeningocele and tethered cord which accompanies severe symptoms, preserving neurological function is the utmost importance by closing myelomeningocele and detethering the neural cord. This is a highly complex procedure that requires extreme caution not to injure the rectum in which case can cause a cerebrospinal fluid infection. For duplication of lower limb which not only hinders patients’ gait but also is highly visible and may affect patients’ self-esteem, excision of the supernumerary, non-functional pair of limb is often carried out.

For example, using cheat codes from Doom in Descent only displays sarcastic messages from the programmers on screen; using codes from Descent in its sequel Descent II lowers the player's shields and energy to 1%.Descent 2 Interactive Demo Version Cheats Codes from Doom used in Heretic give the opposite of the desired effect, such as instant death instead of invulnerability or stripping weapons instead of providing them. The original Dooms "god mode" code "IDDQD" is non-functional in Doom 3, but produces a console message: "Your memory serves you well." Other codes make purely cosmetic changes—for example, to what the player character is wearing—but do not enhance the progress of the game.

Sekolah Menengah Jenis Kebangsaan Seg Hwa, shortened SMJK Seg Hwa is a national-type public high school located at Jalan Tahang Rimau, District of Segamat, Johor, Malaysia. The school is well known for its symbolic clock tower, gigantic stone steps, Chinese pavilions and non-functional water fountain . The clock tower, "Xi Yin Lou 惜阴楼", was a gift from the school 11th alumni. It was built in 1962 with an engraving of a famous Chinese poem by Tao Qian (陶渊明) from the Jin Dynasty: "盛年不重来，一日难再晨; 及时当勉励，岁月不待人。" School compound The Principal of the school is Mr Tai Chen Kiun.

A British L2-A2 fragmentation grenade The L2 series (with a green shell) is the British version of the M26; it has a 4.4 second fuze. The L2 was like the early M26 (except it used the L25 series fuze), the L2A1 was like the product- improved M26A1, and the L2A2 was a variant of the L2A1 with a redesigned fuze well for ease of mass production.Military Factory L2 Anti-Personnel Fragmentation Hand Grenade The L3 series (with a light blue shell and a black powder filler) is the Practice grenade variant. The L4 series (with a dark blue shell, non-functional fuze, and no filler) is the inert Drill grenade variant.

A third kind of transition, the hybrid transition, uses the phrase "consisting essentially of". The effect of this transitional phrase is to leave the claim "open" to include additional elements, but only if those additional elements do not materially affect the basic and novel characteristics of the claimed combination. In this instance, the pencil with the eraser added might still not be infringing, but a pencil with a fin or a non-functional button would still infringe, because the thing that was added would serve no purpose material to the claimed functions of the pencil. This language assists in avoiding prior art, but is broad enough to capture imperfect attempts to copy the patented device.

She has also begun adopting non-functional educational institutes around the area. In 2010, Daud put together a financing deal of $24 million with the IFC, a member of the World Bank Group to offer hospital care in India and the UAE. According to the plan presented, $21 million would be put toward a strong hospital in Nagpur, India and $3 million would go toward an energy-efficiency project in the Zulekha group's Sharjah facility. Alongside healthcare services, Dr. Zulekha Daud leads numerous community initiatives across her facilities in India and the UAE that promote the early detection and prevention of life-threatening diseases such as breast cancer, colorectal cancer, cervical cancer and cardiovascular diseases.

Similarly, FUT3 has a functional dominant allele (Le) and a non-functional recessive allele (le). The proteins produced by the FUT2 and FUT3 genes modify type I oligosaccharide chains to create Lewis antigens. These oligosaccharide chains are similar to the type II chains of the ABO blood system, with a single bond in a different position. The link between the Lewis blood group and secretion of the ABO blood group antigens was possibly the first example of multiple effects of a human gene: the same enzyme (fucosyltransferase2) which converts the Le-a antigen to Le-b is also responsible for the presence of soluble A, B and H antigens in bodily fluids.

The technology (Object Oriented components) underlying the toolkit has proved to be a powerful and flexible solution for managing the complexity of seasonal adjustment algorithms and integrating the major well-known SA engines provided by the Bank of Spain and USCB. In addition, it could easily be embedded in many different environments allowing fast developments and extensions. In parallel with the adoption of the ESS guidelines on SA, the SASG has launched a task force on the SA tools users\' requirements (February - April 2008) in order to define the functional and non functional requirements for a new SA tool DEMETRA+. The role of this community is the common sharing and testing of the new tool DEMETRA+ developed by BNB.

It Later emerged from Leaked American Diplomatic Cables that Shahbaz Sharif was secretly telling Zardari and Americans that "the future of the then-non-functional chief justice was up for negotiation" and PMLN just wanted a face saving exit. Shahbaz said Chaudhry was a problematic judge whose powers would need to be carefully curtailed. Shahbaz also said Chaudhry could be removed after some sort of face-saving restoration had been carried out. Shahbaz Sharif said PMLN would agree to any constraints President Zardari might want placed on Chaudhry, "including curtailment of his powers to create judicial benches, removal of his suo motu jurisdiction, and/or establishment of a constitutional court as a check on the Supreme Court".

Xbox 360 Wireless controller Up to four controllers are able to connect to Xbox 360, including wired and wireless gamepads. The wireless controllers run on either AA batteries (Alkaline or rechargeable) or on a rechargeable battery pack. The wired controllers may be connected to any of the USB ports on the console (the number of ports depends on model: old-style 360s have two at the front and one on the rear, while Xbox 360 S units have two at the front and three at the rear), or to a USB hub. USB keyboards are also supported, but only for inputting text and navigating the dashboard; additionally, the number pad and hotkeys are non-functional.

The A1200 was the only Amiga model to have this unique 22-pin connector (some revisions of the A1200 motherboard have additional non-functional pins). However, as the address and data signals used by the interface are available through the internal expansion connectors of other Amiga models, clock port adaptors were later created by third-party developers for these systems. This enables owners of other popular models, such as the Amiga 500 or Amiga 600, to use the hardware created for this interface. Due to the popularity of clock port devices, developers even included one or more compatible clock port interfaces on Amiga Zorro boards to allow hosting such devices on these systems.

DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, increased oiliness of hair and skin, and mild acne. DHEA is potentiated locally via conversion into testosterone and dihydrotestosterone (DHT) in the skin and hair follicles. Women with complete androgen insensitivity syndrome (CAIS), who have a non-functional androgen receptor (AR) and are immune to the androgenic effects of DHEA and other androgens, have absent or only sparse/scanty pubic and axillary hair and body hair in general, demonstrating the role of DHEA and other androgens in body hair development at both adrenarche and pubarche.

Mutagens may also modify the DNA sequence; the changes in nucleic acid sequences by mutations include substitution of nucleotide base-pairs and insertions and deletions of one or more nucleotides in DNA sequences. Although some of these mutations are lethal or cause serious disease, many have minor effects as they do not result in residue changes that have significant effect on the structure and function of the proteins. Many mutations are silent mutations, causing no visible effects at all, either because they occur in non-coding or non- functional sequences, or they do not change the amino-acid sequence due to the redundancy of codons. Some mutagens can cause aneuploidy and change the number of chromosomes in the cell.

The protagonist of Immune Attack is a teenaged prodigy in the near-future with a unique immunodeficiency in which the immune system is "present, yet non- functional" - as if all the immune cells have forgotten what to do. The hero decides to take matters into her own hands, and allies herself with a team of scientists to create a nanobot with the abilities to teach cells how to fight bacterial and viral infections. The player assumes the role of a pilot remote- controlling the nanobot Explorer. With the help of advisors, the player must learn about the different cells and environments in the human body in order to determine how to train the immune system.

A figure depicting the process of T cell / thymocyte positive and negative selection in the thymus Thymocytes which pass β-selection express a T cell receptor which is capable of assembling on the surface. However, many of these T cell receptors will still be non-functional, due to an inability to bind MHC. The next major stage of thymocyte development is positive selection, to keep only those thymocytes which have a T cell receptor capable of binding MHC. The T cell receptor requires CD8 as a coreceptor to bind to MHC class I, and CD4 as a coreceptor to bind MHC class II. At this stage thymocytes upregulate both CD4 and CD8, becoming double positive cells.

Once these pseudogenes are inserted back into the genome, they usually contain a poly-A tail, and usually have had their introns spliced out; these are both hallmark features of cDNAs. However, because they are derived from an RNA product, processed pseudogenes also lack the upstream promoters of normal genes; thus, they are considered "dead on arrival", becoming non-functional pseudogenes immediately upon the retrotransposition event. However, these insertions occasionally contribute exons to existing genes, usually via alternatively spliced transcripts. A further characteristic of processed pseudogenes is common truncation of the 5' end relative to the parent sequence, which is a result of the relatively non- processive retrotransposition mechanism that creates processed pseudogenes.

"The Importance of Coax Connector Design Above 110 GHz". 2014\. Such cost and reliability considerations probably drove the design decision to use female jack connectors on many computer terminals (and some personal computers) for the serial port, in direct violation of the connector gender convention specified in the RS-232 standard for "DTE" computer equipment. This confusing reversal of the RS-232 connector gender convention would cause many hours of frustration for ill-informed end users, as they tried to troubleshoot non-functional serial port equipment connections. In the case of electrical power connections, designers do not reverse connector gender in such a casual fashion, because exposing live AC line power on male connectors is unsafe and generally illegal.

Ratsat, or DemoSat, was a 165-kilogram (363-pound) non-functional boilerplate spacecraft used as a mass simulator on the fourth flight of the Falcon 1 rocket, launched 28 September 2008. The Falcon 1 launch that carried Ratsat to orbit was the first successful orbital launch of any privately funded and developed, liquid-propellant carrier rocket, the SpaceX Falcon 1, something only six nations had successfully accomplished previously. The launch, identified as Falcon 1 Flight 4, was conducted by SpaceX, and also marked the first time the Falcon 1 rocket successfully achieved orbit, after three consecutive failures on the three previous launch attempts. Ratsat remained bolted to the second stage of the carrier rocket after reaching low Earth orbit.

In areas such as Mali, the division supports previously existing airlines by increasing fleet size and reviving currently non-functional companies in order to provide much-needed air support for the development projects within the region. In Uganda, a new airline, Air Uganda, formed in 2007 and ended in 2014, filled a void that had been vacant since the national airline, Uganda Airlines, collapsed in May 2001. In addition, the multiple airline companies of AKFED are connected through a network known as “Group Celestair”, which serves to collectively increase the efficiency and scope of support for the various airlines throughout the region. AKFED is currently considering possible airport management opportunities at a multitude of locations.

Thus Frederick attempted to encourage Russia to direct its expansion towards weak and non-functional Poland instead of the Ottomans. Bar Confederation 1768-72 Although for a few decades (since the times of the Silent Sejm) Russia had seen weak Poland as its own protectorate, Poland had also been devastated by a civil war in which the forces of the Bar Confederation attempted to disrupt Russian control over Poland. The recent Koliyivschyna peasant and Cossack uprising in Ukraine also weakened Polish position. Further, the Russian-supported Polish king, Stanisław II Augustus, was seen as both weak and too independent-minded; eventually the Russian court decided that the usefulness of Poland as a protectorate had diminished.

Oil spills in Nigeria are a common occurrence; it has been estimated that between have been spilled since oil drilling started in 1958. The government estimates that about 7,000 spills occurred between 1970 and 2000. The process of remediating some of the contaminated site was conducted in Kwawa community, Khana Local Government Area of Rivers State, after the United Nations Environment Programme (UNEP) released an environmental assessment of Ogoniland in 2011, a remediation project popularly refer to as OGONI CLEAN-UP. Oil spill causes include corrosion of pipelines and tankers (accounts for 50% of all spills), sabotage (28%), and oil production operations (21%), with 1% of the spills being accounted for by inadequate or non-functional production equipment.

Boeing is developing a roll-on/roll-off aerial refueling kit, which would give the V-22 the ability to refuel other aircraft. Having an aerial refueling capability that can be based on Wasp-class amphibious assault ships would increase the F-35B's strike power, removing reliance on refueling assets solely based on large Nimitz-class aircraft carriers or land bases. The roll-on/roll-off kit can also be applicable to intelligence, surveillance and reconnaissance (ISR) functions.Boeing developing Osprey aerial refueling kit Flightglobal.com, 10 April 2013 Boeing funded a non-functional demonstration on a VMX-22 aircraft; a prototype kit was successfully tested with an F/A-18 on 5 September 2013.

The bioluminescent fish Parapriacanthus ransonneti, which obtains its luciferase protein from its diet, rather than encoding it within its own genome A kleptoprotein is a protein which is not encoded in the genome of the organism which uses it, but instead is obtained through diet from a prey organism. Importantly, a kleptoprotein must maintain its function and be mostly or entirely undigested, drawing a distinction from proteins that are digested for nutrition, which become destroyed and non-functional in the process. This phenomena was first reported in the bioluminescent fish Parapriacanthus, which has specialized light organs adapted towards counter- illumination, but obtains the luciferase enzyme within these organs from bioluminescent ostracods, including Cypridina noctiluca or Vargula hilgendorfii.

Intraoperatively, University of Miami neurosurgeons and neurologists use certain techniques to reduce and prevent damage to essential areas of the brain used for language, muscle skills, and sensation. In order to avoid damage to these areas, neurosurgeons must determine the location of these functional areas that are mapped while the patient is awake. Using special mapping procedures while the patient is awake during the operation, certain areas of the brain are stimulated with a mild electric current to determine the functionality of various areas. If certain areas are critical for the patient's function, that area of the brain is preserved, meanwhile the tumor in the non-functional areas will be targeted and removed.

This is exactly found to be true in eukaryotic organisms living today, even when introns are hundreds of thousands of bases long. They should also be mostly non- functional, and they are. Except for some intron sequences including the donor and acceptor splice signal sequences and branch point sequences, and possibly the intron splice enhancers that occur at the ends of introns, which aid in the removal of introns, the vast majority of introns are devoid of any functions. The Split Gene theory does not preclude for rare sequences within introns to fortuitously exhibit functional elements that could be used by the genome and the cell, especially because the introns are extremely long, which is found to be true.

As they talk, it is revealed that Peter, Olivia, and young Etta were enjoying a picnic in a park on the day of the Observers' invasion, and Etta went missing in the confusion. Subsequently, Peter and Olivia had separated; Peter going to search for Etta, who had been taken by the Observers, and Olivia joining Walter in fighting them. Etta takes them to a hidden facility where human resistance members have found the device that Olivia had been trying to locate, the Transilience Thought-Unifier Model-11, which is capable of restoring Walter's thoughts, though they believe the device to be non-functional. While there, they are able to track Walter's capture to a secured Observer facility.

This method attempts to treat the infection by disrupting the CCR5 gene, such as introducing the CCR5-Δ32 mutation using a recombinant adenoviral vector or forcing DNA repair by nonhomologous end joining, which is prone to error and results in a non-functional gene. As a consequence, resulting in the expression of nonfunctional CCR5 co-receptors on CD4+ T cells, providing immunity against infection. The zinc finger nucleases that have been synthesized for this treatment are manufactured by combining FokI Type II restriction endonucleases with engineered zinc fingers. The number of zinc fingers attached to the endonuclease controls the specificity of the ZFN since they are engineered to preferentially bind to specific base sequences in DNA.

Sonos later settled a class action lawsuit related to its decision to intentionally cause the CR100 to cease to function. Sonos was criticized by media outlets in December 2019 for its "Recycle Mode", which bricks devices that users register into the company's trade-in program. Customers who participate in the program receive a 30 percent discount on a purchase of a new Sonos device, but the registration puts the device into Recycle Mode, which starts a timer that turns the device permanently non-functional in 21 days. An electronic waste recycler criticized the procedure on Twitter for being environmentally unfriendly, stating that it discourages reuse by preventing recyclers from reselling functional Sonos units.

There are elements of both in this song. Underlining the text ‘The earth holds you fast in her darkness,’ the accompaniment illustrates the darkness and depth of the grave with low descending octaves in the left hand as the right hand exhibits a series of non-functional chords that obscure the light with chromatics filling in every crack. Then, there is specific text painting, when the melody exhibits a descending whole tone scale, depicting ‘from your depths,’ then rises at ‘you shall rise as Spring’s most beautiful flower!” Finally, there is a cadence in D major, the key of optimism, symbolizing the emergence of Spring from Winter, or, the emergence of life from death.

U.S. Navy sailor training with an M4 "Blue Gun" U.S. Navy sailor training with an M16 "Red Gun" Glock training pistols In the United States military, a rubber duck, or "rubber ducky", or "Blue Gun", or "Red Gun" is a non- functional training weapon that is fully or partially made of rubber or plastic. They are usually M16 rifles, and are commonly used in basic training. Trainees are issued rubber ducks to add realism to training without the dangers and maintenance inherent to real firearms. For example, rubber ducks are sometimes issued to troops before they have been properly trained to use actual rifles in order to become familiar with basic care, and responsible handling.

Cosmetically, every SL received a revised front end, front grille treatment and larger non-functional side 'vents' behind the front wheels. All variants also received adaptive LED front headlights with integrated daytime running lights and turn signals, leaving the below-bumper intake area free from lighting. The LED tail lights received single-colour red or red-and-amber lenses instead of the red and white of the pre-facelift models. Front and rear bumper assemblies were redesigned to align more closely with recent models introduced by Mercedes, while selected convenience and driver assistance technologies, introduced earlier on various other Mercedes models, were made optionally available, including revised Active Body Control (ABC), now with the "Curve Tilting" function from the S-Class Coupe.

The Newburgh Sting is a 2014 documentary film about the Federal Bureau of Investigation's sting operation on four Muslim men involved in the 2009 Bronx terrorism plot. Beginning in 2008, an FBI informant, Shaheed Hussain, recorded hours of conversations with the men who were ultimately arrested and convicted of planting three non-functional bombs next to two synagogues in Riverdale, Bronx and for planning to use Stinger missiles to shoot down United States military cargo planes near Newburgh, New York. The documentary shows that the four men were coaxed into participating in the plot by an FBI informant and offered incentives including $250,000. The men's lawyers, including Sam Braverman, who is featured prominently in the film, argue that this was a case of entrapment.

Offenders can be judged as arms traffickers and subjected to penalties as high as capital punishment and life imprisonment. Prior to the Beijing Olympics, airsoft was an increasingly popular sport among Chinese military enthusiasts. However, since the 2008 standards came out, there has been thousands of arrests and seizures made on toy gun merchants and consumers for "arms trafficking" and "illegal possession of firearms", because people are often unaware that their hobbies are now suddenly spelt as illegal under the new standards, and the Ministry of Public Security or police never actively informed the public about the change. Law enforcement is also highly arbitrary, and many of the merchandises confiscated are actually either non-functional props or well below the replica limit.

The vomeronasal organ (VNO), or Jacobson's organ, is the paired auxiliary olfactory (smell) sense organ located in the soft tissue of the nasal septum, in the nasal cavity just above the roof of the mouth (the hard palate). The name is derived from the fact that it lies adjacent to the unpaired vomer bone (from Latin 'plowshare', for its shape) in the nasal septum. It is present and functional in all snakes and lizards, and in many mammals, including cats, dogs, horses, cattle, pigs, and some primates; in humans it is present, but is vestigial and non-functional. The VNO contains the cell bodies of sensory neurons which have receptors that detect specific non-volatile (liquid) organic compounds which are conveyed to them from the environment.

Many such devices contain non-functional circuitry or naively constructed approximations of radio transmitters. A few do have functional circuitry, putting out a weak signal with a function generator or a simple timer circuit, but are still largely useless in comparison with a coil-based metal detector; others have been found to contain intentionally obfuscated or completely superfluous components (from individual components such as inductors or ribbon cables up to, in some cases, pocket calculators), often indicative of intentional fraud, incompetence, or both, by the designer. Such functioning circuitry as exists in such devices usually has no obvious way (motor, solenoid, etc.) to connect to any rotating joint in the device either, meaning the devices are often entirely dependent on the ideomotor effect to function.

Airborne guns are airborne artillery pieces, designed for use by paratroopers. They are generally specific or specialised types of infantry support guns, being in the traditional sense capable of being broken down into smaller loads for transport by aircraft and soldiers, thus also suitable as mountain guns. The historical concept of the "airborne guns" is to some degree outdated, their role being filled by mortars, wire-guided missiles, and/or light anti- tank weapons. As it has been many decades since two industrialized great powers engaged directly in warfare, the concept of the "airborne gun" allowing paratroopers to maintain an airhead against an armored force is in that sense non-functional, but currently, all three of the U.S. Army's howitzers (for example), are air-mobile.

The Navi Mumbai Municipal Corporation in collaboration with Green Society Forum has created various murals by Upcycling different types of waste. It has been done to create an awareness amongst the residents, working people and visitors on 4 R's Reduce, Reuse, Recycle and Retain E-Waste: Mother India Board: Waste Management by giving new life to e-waste ie. upcycling, it has Developed two Mother India Boards by using non functional mother boards of Laptops. The first one is installed is Navi Mumbai Municipal Corporation Headquarter, Palm Beach Road, Belapur in the NMMC's Solid Waste Management Directors cabin and second one in Swachhta Park, Nisarg Udyan, Kopar Khairane Metal Waste: Kinetic Art Sculpture: As NMMC has a biggest Industrial Zone.

Upon Annie's return, she forces a weakened Paul to burn the manuscript for Fast Cars in exchange for his painkillers. Annie sets up an office for Paul – consisting of an antique Royal typewriter with a non-functional N-key, writing paper and a wheelchair – for the purpose of writing a new Misery novel that will bring the character back from the dead. Biding his time and likening himself to Sheherezade, Paul begins a new book, Misery's Return, and allows Annie to read the work in progress and fill in the missing Ns. The text includes excerpts of the new book as Paul writes. Paul manages to escape his room using his wheelchair on several occasions, searching for more painkillers and exploring the house.

The hood-scoop found on the American Outback Sport was non-functional but was probably included because the American and Japanese versions were built at the same factory in Japan. The Outback Sport was offered with optional equipment, such as a gauge pack installed on top of the dashboard, that included a digital compass, outside temperature and barometer or altimeter readings. Trim levels were LX, GL and Sport generation. LX models were front-wheel drive, and powered by a 1.6-liter engine. GL trim levels were either front-wheel drive (Subaru badged these 2WD) or all-wheel-drive (badged AWD); cars launched in 1993 had a choice of 1.6- and 1.8-liter flat-4 engines, the 1.6 being available with 2WD, the 1.8 an AWD version only.

The filesystem had a similar set of properties to the native BeOS file system BFS, but some of the more advanced features (live queries and attributes) were either broken or non-functional in many of the Beta releases of the software. The BeOS uses ELF format executable files, much as many other operating systems. BeIA uses an extended version of ELF, the name of which is unknown but which has come to be known as CELF, from the CEL magic word within the executable header and the fact that it is derived from ELF format executables through a compression process. The CELF (Compressed ELF) files use a patented technique to compress the op codes within the executable and reduce the overall footprint of each executable file.

Psoriasis on the hands can be caused by faulty JAK-STAT signalling JAK3 can be used for the signalling of IL-2, IL-4, IL-15 and IL-21 (as well as other cytokines); therefore patients with mutations in the JAK3 gene often experience issues affecting many aspects of the immune system. For example, non-functional JAK3 causes SCID, which results in patients having no NK cells, B cells or T cells, and this would make SCID individuals susceptible to infection. Mutations of the STAT5 protein, which can signal with JAK3, has been shown to result in autoimmune disorders. It has been suggested that patients with mutations in STAT1 and STAT2 are often more likely to develop infections from bacteria and viruses.

The grille was also redesigned, and the hood had its non-functional hood scoop removed. American Motors changed the designation to "Metropolitan 1500" to differentiate it from the earlier models. The interior was also changed to incorporate a "houndstooth" check material for the seats trimmed with white vinyl. The dashboard was also now painted black, rather than the body color as was the case for Series I and II Metropolitans. Series 3 hood ornament Rear view of the Series III The MSRP for Series III models was $1,527 (Hardtop) and $1,551 (Convertible). After VIN E35133 (16 April 1957) the exterior colors were changed to P910 "Sunburst Yellow", P912 "Berkshire Green", and P913 "Mardi- Gras Red" with P914 "Frost White" as contrast.

Computations can be jointly executed by a cluster of co-operating P3 processes. This cluster is in many ways analalogous to a multicellular organism: like cells within an organisms, individual P3 processes can specialise. For example, in the case of the Daisy pattern recognition system, the cluster consists of (ipm) processes which pre-process pattern-data, (floret) processes which run the PSOM neural nets used to classify those patterns, and (vhtml) processes which communicate the identity of patterns Daisy has discovered to the user. In addition, the Daisy cluster also has specialist (maggot and kepher) processes to clear and recycle file and memory space and (lyosome) processes which destroy and replace other processes within the cluster which have become corrupted and therefore non functional.

The AC-5 flight (Atlas-C # 156D) on 2 March 1965 at 13:25 GMT from Cape Kennedy in a highly elliptical orbit, with a payload (Surveyor SD-1) of 951 kg, was only intended to carry out a single burn of the Centaur C, and program officials felt confident. This mission was designed to rehearse a complete Centaur upper stage burn in support of the Surveyor lunar lander program. On a nominal mission, the Centaur would boost its payload on a direct ascent trajectory to the Moon. On this test flight, NASA planned to deliver the payload, a non-functional dynamic model known as SD-1, into an orbit of 167 × 926,625 km that simulated a lunar transfer trajectory.

The ATAM process consists of gathering stakeholders together to analyze business drivers (system functionality, goals, constraints, desired non-functional properties) and from these drivers extract quality attributes that are used to create scenarios. These scenarios are then used in conjunction with architectural approaches and architectural decisions to create an analysis of trade-offs, sensitivity points, and risks (or non-risks). This analysis can be converted to risk themes and their impacts whereupon the process can be repeated. With every analysis cycle, the analysis process proceeds from the more general to the more specific, examining the questions that have been discovered in the previous cycle, until such time as the architecture has been fine-tuned and the risk themes have been addressed.

These steel floor panels weighed less than the previous fiberglass floor and reduced interior noise levels. Horsepower rose to for the base L-48 engine; for the optional L-82. To further reduce cabin noise levels, cowl induction was dropped in favor of the air cleaner ducted over the radiator, picking up outside air from the front of the car, thus reducing wind turbulence at the base of the windshield. The hood was carried over, with its cowl vent grille and induction system opening becoming non-functional. The optional cast aluminum wheels were finally made available, which reduced the unsprung weight of the car by 32 pounds. Nearly 15% of the cars were ordered with the new wheels at a cost of $299.

Cosmetically, every SL received a revised front end, front grille treatment and larger non-functional side 'vents' behind the front wheels. All variants also received adaptive LED front headlights with integrated daytime running lights and turn signals, leaving the below bumper intake area free from lighting. The LED tail lights received single colour red or red and amber lenses instead of the red and white of the pre-facelift models. Front and rear bumper assemblies were redesigned to align more closely with recent models introduced by Mercedes, while selected convenience and driver assistance technologies, introduced earlier on various other Mercedes models, were made optionally available, including revised Active Body Control (ABC), now with the "Curve Tilting" function from the S-Class Coupe.

Approximately 60% of the phones ReCellular collected were reprogrammed and sold for reuse. For the phones that are successfully repaired, " About half of the rebuilt phones end up with domestic re-sellers, the other half in developing countries in Africa, South America, and Asia. They typically sell for $16 to $18, of which ReCellular's partners receive as much as $5 to $10 per phone for charities of their choosing." Obsolete or non-functional phones are passed on to Sims Recycling Solutions to be dismantled and recycled in order to reclaim valuable materials, such as: gold, silver and palladium from circuit boards; copper wiring from phone chargers; nickel, iron, cadmium and lead from battery packs; and plastic from cases and accessories.

Studies in Drosophila melanogaster indicate pallidin is non-essential for synaptic vesicle homeostasis or anatomy but is essential under conditions of increased neuronal signaling to maintain vesicular trafficking from endosomes via recycling mechanisms. The effects of a non-functional Bloc1s6 gene (encoding for pallidin) on the metabolome of the post-natal mouse hippocampus were explored using LC-MS, revealing altered levels of a variety of metabolites. Particularly intriguing effects include an increase in glutamate (and its precursor glutamine), an excitatory neurotransmitter linked to schizophrenia, as well as decreases in the neurotransmitters phenylalanine and tryptophan. Overall, modifications in the metabolome of these mice extend to nucleobase molecules and lysophospholipids as well, implicating further dysregulation effects of BLOC-1 deficiencies to plausible molecular contributions of schizophrenia.

The most traditional application area for VIATRA2 – started as early as 1998 – is to support the transformation-based dependability analysis of system models taken from various application areas (safety-critical and/or embedded systems, robust e-business applications, middleware, service oriented architecture) described using various modeling languages (BPM, UML, etc.) during a model-driven systems engineering process. Such a model (and transformation)-based dependability analysis typically also includes the verification and validation, the testing, the safety and security analysis as well as the early assessment non-functional characteristics (such as reliability, availability, responsiveness, throughput, etc.) of the system under design. In addition, model transformations for specification, design, deployment, optimization or code generation in traditional model-driven systems engineering are also focal areas for VIATRA2.

2 ways a pseudogene may be produced Various mutations (such as indels and nonsense mutations) can prevent a gene from being normally transcribed or translated, and thus the gene may become less- or non-functional or "deactivated". These are the same mechanisms by which non-processed genes become pseudogenes, but the difference in this case is that the gene was not duplicated before pseudogenization. Normally, such a pseudogene would be unlikely to become fixed in a population, but various population effects, such as genetic drift, a population bottleneck, or, in some cases, natural selection, can lead to fixation. The classic example of a unitary pseudogene is the gene that presumably coded the enzyme L-gulono-γ-lactone oxidase (GULO) in primates.

Jörg C. Meyer is the official scientific glassblower of the University of California, Irvine.... Meyer was born in Berlin, Germany, and learned glassblowing from his father and grandfather, who both worked in the same trade. He traveled to Australia, and blew glass for the Australian National University in Canberra, before moving again to Southern California. He was hired at UC Irvine by chemist Frank Sherwood Rowland at the founding of the university in 1965, and worked with Rowland and Mario J. Molina on their Nobel-prize-winning research on ozone depletion. As well as making scientific equipment for chemists, physicists, and atmospheric scientists, his creations have included a glass baseball mitt for Ralph J. Cicerone and a non-functional glass clarinet for UCI chemist Harold W. Moore.

This article mainly deals with POSTs on personal computers, but many other embedded systems such as those in major appliances, avionics, communications, or medical equipment also have self-test routines which are automatically invoked at power-on. The results of the POST may be displayed on a panel that is part of the device, output to an external device, or stored for future retrieval by a diagnostic tool. Since a self-test might detect that the system's usual human-readable display is non-functional, an indicator lamp or a speaker may be provided to show error codes as a sequence of flashes or beeps. In addition to running tests, the POST process may also set the initial state of the device from firmware.

Space debris describes particulates in the vacuum of outer space, specifically particles originating from human activity that remain in geocentric orbit around the Earth. The International Association of Astronauts define space debris as "any man-made Earth orbiting object which is non- functional with no reasonable expectation of assuming or resuming its intended function or any other function for which it is or can be expected to be authorized, including fragments and parts thereof". Space debris is classified by size and operational purpose, and divided into four main subsets: inactive payloads, operational debris, fragmentation debris and microparticulate matter. Inactive payloads refer to any launched space objects that have lost the capability to reconnect to its corresponding space operator; thus, preventing a return to Earth.

The folding is modulated by a sensing mechanism producing either a Rho-independent terminator, resulting in interrupted transcription and a non-functional RNA product; or an anti-terminator structure, resulting in a functional RNA transcript. There are now many equivalent examples where the translation, not transcription, is terminated by sequestering the Shine-Dalgarno sequence (ribosomal binding site) in a hairpin-loop structure. While not meeting the previous definition of (transcriptional) attenuation, these are now considered to be variants of the same phenomena and are included in this article. Attenuation is an ancient regulatory system, prevalent in many bacterial species providing fast and sensitive regulation of gene operons and is commonly used to repress genes in the presence of their own product (or a downstream metabolite).

The presence of two Francophones and one Anglophone, plus the climbing skills involved, led the chief investigator on the case to believe the thieves involved in both incidents had been local, and possibly the same. That, and their apparent knowledge of the skylight's non-functional alarm, had at first fostered a theory that someone on the inside at the museum had aided the thieves in some way. This is a common phenomenon when museums are robbed; two New York City detectives who specialized in art crime said as much when commenting about the Montreal case later in 1972. However, the Montreal police considered that speculation too broad to be helpful in focusing their investigation, and evidence did not bear it out.

The social element anticipates an increase in motivation, and found that users took an average of 700 more steps per day when they had friends on the app. Users can also choose to share their progress pictures and achievement badges. The first product released was the Fitbit Tracker, which was released in 2014. In 2017, the company released its Fitbit Ionic smartwatch, and in 2018, it released a redesigned, lower-priced version of the smartwatch called the Versa. The Fitbit Charge 3, a wristband health and fitness tracker introduced in October 2018, was the first device to feature an oxygen saturation (SPO2) sensor; however, as of January 2019, it was non-functional and Fitbit did not provide an implementation timeline.

The Glasgow, Paisley, Kilmarnock and Ayr Railway and the Glasgow, Paisley and Greenock Railway, which both obtained Parliamentary Approval on 15 July 1837 and were later to become part of the Glasgow and South Western Railway and the Caledonian Railway, respectively, were built to standard gauge from the start. The standard gauge of , also known as the Stephenson gauge after George Stephenson, was adopted in Great Britain after 1846 after the passing of the Regulating the Gauge of Railways Act 1846. A few remnants of old lines remain, but are non functional with the exception of one example of the St Michael's Mount Tramway at St Michael's Mount in Cornwall. It is a partial underground railway that used to bring luggage up to the castle.

Plastic hubcap of a Mitsubishi Lancer, covering a steel wheel, bears the automaker's logo Plastic wheelcover with a cable tie to help prevent its accidental detachment from the vehicle's steel road wheel, or to protect against theft Often a hubcap will bear the trademark or symbol of the maker of the automobile or the maker of the hubcap. Early hubcaps were often chrome-plated, and many had decorative, non-functional spokes. Hubcaps were immortalized in the Art Deco styling near the top of one rung of setbacks (ornamental frieze) incorporates a band of hubcaps on the Chrysler Building in midtown Manhattan. Part of the lore of hubcaps is that on bad roads they have a tendency of falling off due to hitting a bump.

Continuous testing is the process of executing automated tests as part of the software delivery pipeline to obtain immediate feedback on the business risks associated with a software release candidate.Part of the Pipeline: Why Continuous Testing Is Essential, by Adam Auerbach, TechWell Insights August 2015The Relationship between Risk and Continuous Testing: An Interview with Wayne Ariola, by Cameron Philipp-Edmonds, Stickyminds December 2015 Continuous testing includes the validation of both functional requirements and non- functional requirements; the scope of testing extends from validating bottom- up requirements or user stories to assessing the system requirements associated with overarching business goals.DevOps: Are You Pushing Bugs to Clients Faster, by Wayne Ariola and Cynthia Dunlop, PNSQC October 2015DevOps and QA: What’s the real cost of quality?, by Ericka Chickowski, DevOps.

Privacy engineering is an emerging discipline within, at least, the software or information system domain which aims to provide methodologies, tools, and techniques such that the engineered systems provide acceptable levels of privacy. In the US acceptable level of privacy is defined in terms of compliance to the functional and non-functional requirements set out through a privacy policy, which is a contractual artefact displaying the data controlling entities compliance to legislation such as Fair Information Practices, health record security regulation and other privacy laws. In the EU, the General Data Protection Regulation sets the requirements that need to be fulfilled. In the rest of the world, the requirements change depending on local implementations of privacy and data protection laws.

The fountain of Tai On building On the first floor of Tai On Building, there is a non-functional fountain. In the past, the first floor terrace had a great broad view of the harbour and because of that reason, it used to be an excellent place for residents and guests to relax and chill out. At one point, the fountain was a place for residence to launch their toy vessels/boats in the late 1960s and early 1970s, it drew quite a large crowd. When the building first opened to the public, there was a huge party with bands and singers on top of the fountain one weekend and since then, it has been nicknamed "The most colourful lighting fountain" by the public.

On only his third mission with the 100th BG, out of 13 B-17s on an October 10, 1943 mission over Münster, the Royal Flush B-17F (USAAF s/n 42-6087) that Rosenthal's crew was flying that day; was the only plane to return, with two engines dead, the intercom and the oxygen system non-functional, and with a large ragged hole in the right wing. In September 1944, Rosenthal's plane was shot down over German occupied France, in which he broke his right arm and nose. He was rescued by the Free French and returned to duty as soon as he had healed. On his second to last mission on February 3, 1945, Rosenthal led a mission to bomb Berlin.

Following the Sixth Central Pay Commission, the UPA Government, in 2008, decided to make promotions for Indian Police Service officers, even for higher ranks, time-bound. Indian Police Service officers are now promoted on a fixed time table, more or less independent of functional requirements or span of responsibility, up to the level of Inspector General of Police, at intervals of 4, 9, 13, 14, and 18 years of service. The time-bound promotion, much of it non-functional, to high ranks apart from increasing the burden on the policing budget has made Delhi Police top-heavy, sluggish, and unwieldy. Delhi Police, which had one Inspector General (IG) until January 1980s, now has 12 officers with ranks senior to IGPs.

Further reports out of Russia suggested a hypertrophic heart, which would be more in line with other cases of sudden death in athletes. In addition to issues with the immediate cause of death for Cherepanov, Russian officials immediately launched an investigation into the emergency response by the team, facilities and paramedics on site. Initial concerns were raised as to why Cherepanov had been allowed to play, if he had a heart condition that should have been picked up by routine medical tests that he was believed to have undergone. The ambulance that is required to be on duty at all KHL games had already left, as there were only five minutes left in the game, and the defibrillator in the arena was non- functional.

These motifs contain two peptide units of Cys-X2-Cys-X4-His-X4-Cys (CCHC), where the X represents a substituted amino acid, that make up the zinc (II) ion binding sites. The binding of zinc (II) in the CCHC binding site is necessary for the domain to be functional and for the stabilization of the conformation of the structure, allowing the NCp7 to carry out the processes required for HIV replication. Since the CCHC binding site is mutation resistant and involved in the replication of HIV-1, it makes a prime candidate for the prevention of HIV through zinc ejectors. By inhibiting the function of NCp7, the viral replication is affected and a non-functional virus that is unable to infect its host is produced.

Domain design takes the domain model produced during the domain analysis phase and aims to produce a generic architecture to which all systems within the domain can conform. In the same way that application engineering uses the functional and non-functional requirements to produce a design, the domain design phase of domain engineering takes the configurable requirements developed during the domain analysis phase and produces a configurable, standardized solution for the family of systems. Domain design aims to produce architectural patterns which solve a problem common across the systems within the domain, despite differing requirement configurations. In addition to the development of patterns during domain design, engineers must also take care to identify the scope of the pattern and the level to which context is relevant to the pattern.

55 After passing through the Benbow Dam, which is non-functional during the winter months, the South Fork Eel receives another tributary called Redwood Creek on the left bank, as it bends north and then west around the community of Redway, California, which is located on a plateau east of the river. The river then passes through another rugged canyon, flowing northeast, then passes the towns of Phillipsville and Miranda which are to the east of the river. West of Miranda, the river receives another medium-sized tributary, Salmon Creek, from the left bank. South Fork Eel River near the Avenue of the Giants in the Humboldt Redwoods State Park The South Fork then flows north to a point where it turns sharply around a ridge and flows due south, then turns back north again.

Parkinson defines tales as "...non-commemorative, non-functional, fictional narratives" that usually employ the key word "narrate" (s _d_ d). He describes it as the most open-ended genre, since the tales often incorporate elements of other literary genres. For example, Morenz describes the opening section of the foreign adventure tale Sinuhe as a "...funerary self-presentation" that parodies the typical autobiography found on commemorative funerary stelas.. The autobiography is for a courier whose service began under Amenemhat I.. Simpson states that the death of Amenemhat I in the report given by his son, coregent, and successor Senusret I (r. 1971–1926 BC) to the army in the beginning of Sinuhe is "...excellent propaganda".. Morenz describes The shipwrecked sailor as an expeditionary report and a travel-narrative myth.

A portrait of Jiang Shunfu, an official under the Hongzhi Emperor, now in the Nanjing Museum. The decoration of two cranes on his chest is a "rank badge" that indicates he was a civil official of the first rank. Processional figurines from the Shanghai tomb of Pan Yongzheng, a Ming dynasty official who lived during the 16th century Governmental institutions in China conformed to a similar pattern for some two thousand years, but each dynasty installed special offices and bureaus, reflecting its own particular interests. The Ming administration utilized Grand Secretaries to assist the emperor, handling paperwork under the reign of the Yongle Emperor and later appointed as top officials of agencies and Grand Preceptor, a top-ranking, non-functional civil service post, under the Hongxi Emperor (r. 1424–25).

In 1972, Christian B. Anfinsen was awarded the Nobel Prize for seminal experiments performed mostly by his postdoctoral fellow, Michael Sela. They showed with artificially unfolded proteins that the primary amino acid sequence suffices to dictate the proper spontaneous refolding of proteins into their functional three-dimensional native structures. Yet, they also observed that proteins can often misfolded and precipitate into large insoluble aggregates. They suggested that in cells, unknown factors could possibly assist protein folding. In 1988, Goloubinoff helped follow up Anfinsen’s finding: a class of highly conserved proteins, many of which belonging to the heat shock proteins and were dubbed “molecular chaperones” by R. John Ellis, could mediate the assembly of protein complexes such as phages and RubisCO, preventing the formation of non-functional, protein aggregates.

These pseudogenes, though non- functional may in some cases still possess promoters, CpG islands, and other features which enable transcription; they thus can still be transcribed and may possess a role in the regulation of gene expression (like SINEs and other non-coding elements). Pseudogenes thus differ from SINEs in that they are derived from transcribed- functional RNA whereas SINEs are DNA elements which retrotranspose by co-opting RNA genes transcriptional machinery. However, there are studies which suggest that retro-transposable elements such as short-interspersed nuclear elements are not only capable of copying themselves in alternate regions in the genome but are also able to do so for random genes too. Thus SINEs can be playing a vital role in the generation of pseudogenes, which themselves are known to be involved in regulatory networks.

In the mid and late 1990s, Sachs' career began to take off. His first major solo show, "Cultural Prosthetics", opened at New York's Morris-Healy Gallery in 1995. Many works from the show conflated fashion and violence, as with HG (Hermès Hand Grenade) (1995) and Tiffany Glock (Model 19) (1995), both of which were models made with Hermès or Tiffany packaging. Although these sculptures were non-functional, another piece - Hecho in Switzerland (1995) - was an actual working homemade gun. Sachs and his assistants would make similar guns and sell them back to the city as part of New York's gun buyback program (for up to $300 each).Celant 2006: 147 His next major show, "Creativity is the Enemy", opened in 1998 at New York's Thomas Healy Gallery and Paris' Galerie Thaddaeus Ropac.

Morrison Hall in 1926 Built in 1924, and designed by North Carolina architect Charles C. Hartmann, Morrison Hall was named for Cameron A. Morrison, former Governor of North Carolina. Placed along university circle, and located south of Noble Hall, and adjacent to the Dudley Building; Morrison Hall was constructed to be nearly identical to that of Noble hall, with the exception of its rusticated stone that surrounds the building's main entrance, as opposed to the brick used on Noble. Another distinctive feature of the building is the carved and incised stone name panel above the non-functional balcony that extends to surround the center third story windows, in addition to retaining its original double-leaf main entrance door. Today, Morrison Hall still serves its original purpose as a residence hall, housing 109 students.

THEC64 Mini (top) next to an original C64 Full-size THEC64 in its original box THEC64 Mini is a Linux-based dedicated home video game console released in 2018 that emulates the Commodore 64, created by Retro Games Ltd. The console takes the form of a decorative half-scale Commodore 64 with two USB and one HDMI port, plus a mini USB connection to power the system. While the console's decorative keyboard is non-functional, a virtual keyboard can be activated via the included THEC64 joystick, or a USB keyboard can be connected to the console. The HDMI attachment is used for connecting the machine to a screen, while the two USB ones are used to connect the THEC64 joysticks and third-party input devices for use with the included software.

While at the architectural level documented in processor data books, any results of misprediction are specified to be discarded after the fact, the resulting speculative execution may still leave around side effects, like loaded cache lines. These can then affect the so- called non-functional aspects of the computing environment later on. If such side effects including but not limited to memory access timing are visible to a malicious program, and can be engineered to depend on sensitive data held by the victim process, then these side effects can result in those sensitive data becoming discernible. This can happen despite the formal architecture-level security arrangements working as designed; in this case, lower, microarchitecture-level optimizations to code execution can leak information not essential to the correctness of normal program execution.

Artist's impression of the TAU spacecraft Space probes have yet to reach the area of the Oort cloud. Voyager 1, the fastest and farthest of the interplanetary space probes currently leaving the Solar System, will reach the Oort cloud in about 300 years and would take about 30,000 years to pass through it. However, around 2025, the radioisotope thermoelectric generators on Voyager 1 will no longer supply enough power to operate any of its scientific instruments, preventing any further exploration by Voyager 1. The other four probes currently escaping the Solar System either are already or are predicted to be non-functional when they reach the Oort cloud; however, it may be possible to find an object from the cloud that has been knocked into the inner Solar System.

Continental Mark VI with optional touring lights (1982 Signature Series two-door) As the Mark V remained popular towards the end of its production, much of its sharp-edged styling was carried over onto Panther- platform Lincolns. Much like the roofline of the Continental/Town Coupe carried over to the 1980 model, the roofline of the Mark VI remained similar to the Mark V (although instead of a hardtop roofline, the Mark VI now wore a fixed B-pillar with framed door glass). The Mark VI had more ornate styling than the Town Car, befitting its place on top of the model line. It sported vacuum-operated concealed headlamps, non-functional fender vents, oval opera windows on the C-pillars, a "Continental-esque" trunk lid, and a slightly different grille.

However, if green pollen fertilized a white stigma, the progeny were white, but if the sexes of the donors were reversed (white pollen on a green stigma), the progeny were green. This non- mendelian inheritance pattern was later traced to a gene named iojap which codes for a small protein required for proper assembly of the chloroplast ribosome. Even though iojap assorts according to Mendel's rules, if the mother is homozygous recessive, then the protein is not produced, the chloroplast ribosomes fail to form, and the plasmid becomes non-functional because the ribosomes cannot be imported into the organelle. The progeny could have functional copies of iojap, but since the chloroplasts come exclusively from the mother in most angiosperms, they would have been inactivated in the previous generation, and so will give white plants.

GPS in an MRTS station showing train timings The system has also been criticised for improper maintenance of stations and the infrastructure and on the windshields of cars parked below the stations, vandalism at several stations, seepage of rainwater through holes in the roofs of stations non-functional station amenities such as lifts and escalators, Station staff have expressed their concern over the Chennai MRTS's safety issues. and conducting various thefts In a recent bid to provide improve the security of the passengers using the network, it has been decided that the MRTS stations would have a single entry and exit point as it has been difficult for the RPF personnel to monitor multiple gates at the same time. According to sources, there is a 20% shortage in the strength of the railway protection force in MRTS stations.

The gene described in this record is a member of 5-hydroxytryptamine receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G proteins, negatively influencing cAMP levels via Gi and Go. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. The 5-HT5A receptor has been shown to be functional in a native expression system. Rodents have been shown to possess two functional 5-HT5 receptor subtypes, 5-HT5A and 5-HT5B, however while humans possess a gene coding for the 5-HT5B subtype, its coding sequence is interrupted by stop codons, making the gene non-functional, and so only the 5-HT5A subtype is expressed in human brain. It also appears to serve as a presynaptic serotonin autoreceptor.

In a minority of lymphedema patients, the condition is caused by mutations in the VEGFC gene and VEGF-C is a potential treatment for lymphedema, even though the underlying molecular cause appears more often in the VEGF-Receptor-3 instead of VEGF-C itself. Because in Milroy's disease (Hereditary lymphedema type I), only one allele is mutated, not all VEGFR-3 molecules are non-functional and it is thought, that high amounts of VEGF-C can compensate for the mutated, nonfunctional receptors by increasing the signaling levels of the remaining functional receptors. Therefore VEGF-C is developed as a lymphedema drug under the name of Lymfactin. Also indirectly VEGF-C can be responsible for hereditary lymphedema: The rare Hennekam syndrome can result from the inability of the mutated CCBE1 to assist the ADAMTS3 protease in activating VEGF-C.

She concluded that Symons "thoroughly undercut the position of feminists who maintained that true sexual equality would be achieved only when peculiarly female sexual experiences were recognized and galvanized as the basis for a new, egalitarian sexuality." David Puts, Khytam Dawood, and Lisa Welling argued in the Archives of Sexual Behavior that while Symons's proposal that the human female orgasm is a non-functional byproduct of orgasm in men is plausible, it is a hypothesis that "currently lacks empirical support", that there is some counter evidence, and that the issue remains unresolved. Dean Lee argued in Biology and Philosophy that Symons's account of the female orgasm has been misinterpreted in the scholarly literature. According to Lee, while Symons's case that the female orgasm is not an adaptation attracted controversy, little attention was given to the alternative explanation of the female orgasm Symons provided.

They then reawaken Kennedy, who must regain his strength to perform the landing—and then decide that the only way they can land is to abandon the original mission profile calling for a Martian orbital capture, and instead dive straight down to the Martian surface. This is an incredibly risky maneuver, one which they almost do not complete because they are about to use an aerobrake deployment system that is non-functional. (Another failure of trust is responsible for this predicament, which they avoid only by some last-minute deduction of NASA's true intentions.) They intend to land in a camp that previous missions have already established—but they end up landing too far away. However, they manage to pool their remaining oxygen to give to Bob and Kennedy, so that they can retrieve a pressurized powered rover to rescue Valkerie and Lex.

Architecture is a degree higher in both abstraction and granularity. Consequentially, architecture is also more topological in nature than design, in that it specifies where major components meet and how they relate to one another. Architecture focuses on the partitioning of major regions of functionality into high level components, where they will physically or virtually reside, what off-the-shelf components may be employed effectively, in general what interfaces each component will expose, what protocols will be employed between them, and what practices and high level patterns may best meet extensibility, maintainability, reliability, durability, scalability, and other non-functional objectives. Design is a detailing of these choices and a more concrete clarification of how functional requirements will be met through the delegation of pieces of that functionality to more granular components and how these smaller components will be organized within the larger ones.

On September 4, 2018, a sheriff's sale of the mall was postponed after Moonbeam Capital Investments filed for bankruptcy for the mall at the last minute. On January 1, 2019, Life Uniform, the last of the mall's chain tenants, departed from the Century III Mall. Century III Mall notice uninhabitable On February 6, 2019, West Mifflin fire code deemed Century III Mall to be "unsafe, unhabitable" due to numerous code violations, such as a non-functional sprinkler system, and no heat. On February 15, 2019, after 15 years, New Dimension Comics said that they were moving to The Waterfront beside Best Buy and Michael's. On February 12, 2019, Moonbeam's website said the mall was sold shortly after they took the sold banner off of their website. On February 16, 2019, the remaining mall tenants were issued eviction notices.

In "winged" cats with cutaneous asthenia, the pseudo-wings only occur on the shoulders, haunches, or back, and the cats can often actively move these growths, suggesting the presence of neuromuscular tissue within them, which is not present within clumps of matted fur alone. The third explanation is a form of conjoining or extra supernumerary limbs. These non-functional or poorly functional growths would be fur-covered and might resemble wings, as in one winged-cat case recently documented by Karl Shuker , in which the "wings" were shown to be supernumerary limbs. There are more than 138 reported sightings of animals claimed to be winged cats, though most of these are clearly nothing more than individuals with clumps of matted fur, some cases of cutaneous asthenia or supernumerary limbs, and others taxidermy frauds (freakshow "grifts"), or just sensationalist tabloid journalism.

Mutations that have been identified in CENPF have been mostly nonsense mutations, which result in the protein being cut short and usually non-functional as a result, but frameshift and splice-site mutations have also been identified. Several of the nonsense mutations that have led to this syndrome have been in exon 12 of the gene (out of 20), but mutations in other exons have been identified. Severity and symptoms of the syndrome have been variable regardless of the type of mutation but generally consistent within families, suggesting the severity may depend on the presence of mutations in other genes that perform similar functions to or otherwise interact with or affect CENPF (a phenomenon known as epistasis). It has been suggested that an interaction between CENPF and NDE1, which causes microlissencephaly when mutated, is related to the microcephaly in Strømme syndrome.

In the painting "Unusual Thursday" of 1951, a jumble of objects in the foreground is contrasted with a latticework bridge leading off into the distance.A House of Her Own: Kay Sage, Solitary Surrealist; Judith D. Suther; U of Nebraska Press, January 1, 1997 "In the first painting [Unusual Thursday] the Sage latticework becomes a set of tracks that lead off into invisible space…"The modern renaissance in American art: presenting the work and philosophy of 54 distinguished artists' 1968; Ralph M. Pearson; Books for Libraries Press, 1968; "For this artist plays with opposites. She contrasts a proper bridge or a functional square block with a controlled tangle of non-functional props and beams, as in Unusual Thursday." Kay Sage consistently identified herself as a Surrealist, and authors who have written about her usually do so as well.

Although PTP1B is generally studied as a regulator of metabolism, some research suggest it may have a role in tumor development, though whether it is oncogenic or tumor suppressive is unclear, as there is data in support of both arguments. The high ROS concentrations within cancer cells provide an environment for potential constitutive inactivation of PTP1B and it has been shown in two human cancer cell lines HepG2 and A431, that up to 40% of the Cys215 residues in PTP1B can be selectively irreversibly oxidized under these cellular conditions resulting in non-functional PTP1B. In addition, PTPN1 genetic ablation in p53 deficient mice resulted in an increased incidence of lymphomas and a decrease in overall survival rates. In contrast, the PTPN1 gene has been shown to be overexpressed in conjunction with HER2 in breast cancer cases.

Over time and subject to conflicting land ownership and administration systems, the old institutions lost their original characteristics and comunidades are now mere societies of rights-holders who are members by birth. After Portuguese rule ended in Goa in 1961, the village development activities, which were once the preserve of the comunidades or more specifically the , became entrusted to the gram panchayat, rendering the non- functional. The emergence of private property in land created a new set of socio-economic relationships at the village level, especially the comunidades and the ghar-bhaatt, the two principal forms of land tenure that came to characterise Portuguese Goa. The working of the comunidades is now tightly controlled by the Goa state government, which supporters of the comunidade movement say leaves little scope for them to act as self-governing units.

ZETA and yellowTAB have been surrounded by controversy. Critics of yellowTAB questioned for a long time the legality of ZETA, and whether yellowTAB had legal access to the sources of BeOS; it is now known that yellowTAB could not have developed ZETA to the extent that they did without access to the source code, but doubts remain as to whether yellowTAB actually had legal access to the code or not. Furthermore, critics did not see ZETA as real advancement of BeOS, but rather as an unfinished and buggy operating system loaded with third party applications that were either obsolete, unsupported, or non-functional. This was particularly true in the initial releases of ZETA, and it was in clear conflict with the attention to detail that BeOS used to stand for, disappointing the BeOS community who at one point had high expectations for ZETA.

These practices included outright fraud in misrepresenting the quality and utility of products in advertising, promoting high-pressure sales practices, adding non-functional styling for deceptive purposes, and engineering products for planned obsolescence. The book also critiqued product differentiation on superficial grounds such as when various manufacturers sell nearly identical products but with different advertising and branding because this practice drives sales to benefit the marketer without also equally increasing value to consumers. Also the book complains of lack of standardization, such as when sewing machines require highly specific parts unique to each brand when the parts could have been designed to be universal. Your Money’s Worth recommended that the public be skeptical about advertising claims, make some products at home, support the government in setting product standards, and support the creation of impartial testing research centers.

After Henry had informed him of the proposal, Frederick suggested a partition of the Polish borderlands by Austria, Prussia, and Russia, with the largest share going to the party most weakened by the recent changes in balance of power, Austria. Thus Frederick attempted to encourage Russia to direct its expansion towards weak and non- functional Poland instead of the Ottomans. Austrian statesman Wenzel Anton Graf Kaunitz counter-proposed that Prussia take lands from Poland in return for relinquishing Silesia to Austria, but this plan was rejected by Frederick. Although for a few decades (since the times of the Silent Sejm) Russia had seen weak Poland as its own protectorate, Poland had also been devastated by a civil war in which the forces of the Bar Confederation, formed in Bar, attempted to disrupt Russian control over Poland.

The 7CPC was constituted against the background of the protracted public protest by ex-servicemen, including by senior officers, that started following the 6th CPC in 2008. These protest highlighted the perceived neglect of the armed forces on matters affecting their pay, pension status, levels, especially in comparison with police officers, and defence civilians, who were granted time bound promotions to the highest ranks, Non Functional Upgrade (NFU), and One Rank, One Pension (OROP) by the UPA Government. To address the dissatisfaction in the armed forces over pay and allowances, the government added an additional term of reference(TOR), not included 5th and 6th Pay Commission, that enjoined the 7th CPC, "to review the principles and structure of emoluments of defence service personnel having regard to the historical and traditional parities". The government did not agree to Armed Forces representation in the CPC.

While the cope was a liturgical vestment, made of rich, colorful fabric and often highly decorated, the cappa nigra was a practical garment, made of heavy plain black wool and designed to provide warmth in cold weather. Whereas the cope's hood had long since become a non-functional decorative item, the hood of the cappa nigra remained functional. The cappa nigra (black cape) was worn at the Divine Office by the clergy of cathedral and collegiate churches and also by many religious, as, for example, it is retained by the Dominicans during the winter months down to the present day. No doubt the "copes" of the friars, to which so many references in the Wycliffite literature and in the writings of Chaucer and Langland are found, designate their open mantles, which were, we may say, part of their full dress, though not always black in colour.

310 Nevertheless, there are many indicators of the sources and elements of Debussy's idiom. Writing in 1958, the critic Rudolph Reti summarised six features of Debussy's music, which he asserted "established a new concept of tonality in European music": the frequent use of lengthy pedal points – "not merely bass pedals in the actual sense of the term, but sustained 'pedals' in any voice"; glittering passages and webs of figurations which distract from occasional absence of tonality; frequent use of parallel chords which are "in essence not harmonies at all, but rather 'chordal melodies', enriched unisons", described by some writers as non- functional harmonies; bitonality, or at least bitonal chords; use of the whole-tone and pentatonic scales; and unprepared modulations, "without any harmonic bridge". Reti concludes that Debussy's achievement was the synthesis of monophonic based "melodic tonality" with harmonies, albeit different from those of "harmonic tonality".

Since the late 70s it has become apparent that the majority of non-coding DNA in large genomes finds its origin in the selfish amplification of transposable elements, of which W. Ford Doolittle and Carmen Sapienza in 1980 wrote in the journal Nature: "When a given DNA, or class of DNAs, of unproven phenotypic function can be shown to have evolved a strategy (such as transposition) which ensures its genomic survival, then no other explanation for its existence is necessary." The amount of junk DNA can be expected to depend on the rate of amplification of these elements and the rate at which non-functional DNA is lost.Another source is genome duplication followed by a loss of function due to redundancy. In the same issue of Nature, Leslie Orgel and Francis Crick wrote that junk DNA has "little specificity and conveys little or no selective advantage to the organism".

In 2012, the ENCODE project, a research program supported by the National Human Genome Research Institute, reported that 76% of the human genome's non-coding DNA sequences were transcribed and that nearly half of the genome was in some way accessible to genetic regulatory proteins such as transcription factors. However, the suggestion by ENCODE that over 80% of the human genome is biochemically functional has been criticized by other scientists, who argue that neither accessibility of segments of the genome to transcription factors nor their transcription guarantees that those segments have biochemical function and that their transcription is selectively advantageous. After all, non- functional sections of the genome can be transcribed, given that transcription factors typically bind to short sequences that are found (randomly) all over the whole genome. Furthermore, the much lower estimates of functionality prior to ENCODE were based on genomic conservation estimates across mammalian lineages.

Compatibility testing is a part of non-functional testing conducted on application software to ensure the application's compatibility with different computing environment. The ISO 25010 standard, (System and Software Quality Models) defines compatibility as a characteristic or degree to which a software system can exchange information with other systems whilst sharing the same software and hardware. The degree to which a product can perform its required functions efficiently while sharing a common environment and resources with other products, without detrimental impact on any other product is known as co-existence while interoperability is the degree to which two or more systems, products or components can exchange information and use the information that has been exchanged. In these contexts, compatibility testing would be information gathering about a product or software system to determine the extent of coexistance and interoperability exhibited in the system under test.

In fact, the stridulitrum is absent from all species except P. pulchella, where a vestigial and non-functional remnant is present. Second, he maintained that there was an "absence of any constriction between postpetiole [= first gastral segment] and gaster", when in fact differentiated presclerites are strongly developed on the second gastral segment but are specialized in form and usually concealed by the posterior portions of the sclerites of the first gastral segment. However, Wheeler did recognise that the apparent similarities between his Phrynoponera species and two Indian Pachycondyla (then Bothroponera) species, Pachycondyla bispinosa (bispinose propodeum) and Pachycondyla rufipes (denticulate dorsal margin of petiole), were superficial and possibly independently acquired. Each of these Phrynoponera-like species lack the extremely specialized morphology of the petiole sternite, helcium, and prora, as well as the characteristic 5-spinose petiole node, that are unique and consistent in the female castes of Phrynoponera.

Production of NSX-R GT, as limited edition of NSX-R, was approved at Honda solely to win at the JGTG and Super GT, because its production-based race car homologation required additional handicap weight for NSX reasoning by such as relatively small aero-projected-area and mid-ship layout, and overcoming the handicap was very difficult in 2003 and 2004 seasons. As the Super GT rule required at least five production cars for any race car version to compete, the production of NSX-R GT was limited to the minimum number, and only one car was actually sold. One clear difference between the second generation NSX-R is the addition of a non-functional garnish snorkel attached to the rear window of the car. In the JGTC NSX race cars however, this snorkel is fully functional, feeding outside air to an individual throttle body intake plenum.

This process has not worked well in the past, primarily because of the conflict of interest, as the " Committee of secretaries" are direct beneficiaries from their examination and recommendation on the implementation of the pay commission reports. For instance, after the 6CPC, the 'committee of secretaries' endorsed and recommended OROP for themselves, and reward all civil servants with of Non Functional Upgrade (NFU), but strongly objected to these benefits being extended to the armed Forces. Similarly the reduction in Pensions of the Armed Forces, after the 3CPC, and imposition of 'rank pay', after 4 CPC, according armed forces generals, depressed military pay, pension, and status, especially so relative to the Indian Police Service. The memorandum by the three service chiefs seeking military representation in the review committee when viewed against this background is not as provocative as the Indian express has sought to make it out.

President of Pakistan, General Pervez Musharraf on 9 March 2007 virtually suspended the Chief Justice of Pakistan, Justice Iftikhar Mohammad Chaudhry, and appointed the next most senior judge available, Justice Javaid Iqbal, as the acting Chief Justice of the Supreme Court. Later it was explained that the senior-most judge after the Chief Justice was Justice Rana Bhagwandas, but since he was away from the country, Justice Javed Iqbal being the second in line was made the acting head of the apex court until Justice Bhagwandas would return. The move to make Justice Iftikhar Chaudhry 'non- functional' was immediately followed by yet another decision by the president to send a reference under Article 209 of the Constitution of Pakistan to the Supreme Judicial Council (SJC) to investigate allegations of misconduct against him. Justice Chaudhry was called on by the President at his Army residence in Rawalpindi on Friday, 9 March 2007.

Through these changes, the two worked to identify and remove elements of the art that could confuse the player, while retaining aesthetic elements that would be generalized by the player as non-functional parts of the level. Once the game's overall artwork was created, Blow and Hellman broke out functional pieces that could be used in Braids level editor. As each world was built up using these pieces, Blow suggested more changes that reflected the tone of each world and avoided art that distracted from the gameplay. "Time and Forgiveness", the first world the player encounters, was drawn to create a feel of exploration and forgiveness, while artwork for "Time and Decision" used a mix of "luxurious domestic objects (nice furniture and fabrics) with rugged outdoor objects (swampy water, rotting piers and nautical rope)" to create an intentionally "incongruous" look to convey aspects of alternate realities.

In the US, since April 15, 2008, pay-per-view movies on cable and satellite television now are flagged to prevent a recording off a pay-per-view channel to a digital video recorders or other related devices from being retained after 24 hours from the ordered time of the film. This is the standard film industry practice, including for digital rentals from the iTunes Store and Google Play. Movies recorded before that point would still be available without flagging and could be copied freely, though as of 2015 those pre-2008 DVR units are well out-of-date or probably non-functional, and the pay-per-view concern is moot for all but special events, as nearly all satellite providers and cable providers have moved to more easily restricted video on demand platforms; pay-per-view films have been drawn down to non- notable content.

Nikon's D700 full-frame DSLR In the 2000s, film became supplanted by digital photography, which had a huge impact on all camera manufacturers, including the SLR market. Nikon, for instance, has ceased production of all film SLRs except for its flagship 35 mm SLR film camera, the F6; and the introductory-level Nikon FM10. Replacing film with a similar-sized digital sensor is possible, but expensive because larger sensor areas imply a greater probability that a defect will render the sensor non- functional. Such "full frame" sensor digital SLRs (DSLRs) however gained early popularity with professional photographers who could both justify their initial high cost, and retain the use of their investment in expensive 35 mm film lenses. By 2008, full-frame models such the Canon EOS 1Ds and 5D, the Nikon D3 and D700, and the Sony Alpha A850 and Alpha A900, designed and priced for professionals, were available.

Much of the biological role of DHT has been elucidated in studies of individuals with congenital 5α-reductase type II deficiency, an intersex condition caused by a loss-of-function mutation in the gene encoding 5α-reductase type II, the major enzyme responsible for the production of DHT in the body. It is characterized by a defective and non-functional 5α-reductase type II enzyme and a partial but majority loss of DHT production in the body. In the condition, circulating testosterone levels are within or slightly above the normal male range, but DHT levels are low (around 30% of normal), and the ratio of circulating testosterone to DHT is greatly elevated (at about 3.5 to 5 times higher than normal). Genetic males (46,XY) with 5α-reductase type II deficiency are born with undervirilization including pseudohermaphroditism (ambiguous genitalia), pseudovaginal perineoscrotal hypospadias, and usually undescended testes.

As of 2019, the highest transistor count in a non- memory chip is a deep learning engine called the Wafer Scale Engine 2 by Cerebras, using a special design to route around any non-functional core on the device; it has 2.6trillion MOSFETs, manufactured using TSMC's 7 nm FinFET process. In terms of computer systems that consist of numerous integrated circuits, the supercomputer with the highest transistor count is the Chinese- designed Sunway TaihuLight, which has for all CPUs/nodes combined "about 400 trillion transistors in the processing part of the hardware" and "the DRAM includes about 12 quadrillion transistors, and that's about 97 percent of all the transistors." To compare, the smallest computer, dwarfed by a grain of rice, has on the order of 100,000 transistors. Early experimental solid state computers had as few as 130 transistors, but used large amounts of diode logic.

Copyright covers an expression in a tangible, fixed medium and often lasts for the life of the author plus 70 years thereafter. If someone makes a statue, they may have a copyright mark on the appearance of that statue, so if someone sees that statue, they cannot then distribute designs to print an identical or similar statue. When a feature has both artistic (copyrightable) and functional (patentable) merits, when the question has appeared in US court, the courts have often held the feature is not copyrightable unless it can be separated from the functional aspects of the item. In other countries the law and the courts may apply a different approach allowing, for example, the design of a useful device to be registered (as a whole) as an industrial design on the understanding that, in case of unauthorized copying, only the non-functional features may be claimed under design law whereas any technical features could only be claimed if covered by a valid patent.

Women with harmful mutations in either BRCA1 or BRCA2 have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. The risk of breast and ovarian cancer is higher for women with a high-risk BRCA1 mutation than with a BRCA2 mutation. Having a high-risk mutation does not guarantee that the woman will develop any type of cancer, or imply that any cancer that appears was actually caused by the mutation, rather than some other factor. High-risk mutations, which disable an important error-free DNA repair process (homology directed repair), significantly increase the person's risk of developing breast cancer, ovarian cancer and certain other cancers. Why BRCA1 and BRCA2 mutations lead preferentially to cancers of the breast and ovary is not known, but lack of BRCA1 function seems to lead to non-functional X-chromosome inactivation.

This conclusion was arrived at despite the widely accepted view, based on genomic conservation estimates from comparative genomics, that many DNA elements such as pseudogenes that are transcribed are nevertheless non-functional. Furthermore, the ENCODE project has emphasized sensitivity over specificity leading possibly to the detection of many false positives. Somewhat arbitrary choice of cell lines and transcription factors as well as lack of appropriate control experiments were additional major criticisms of ENCODE as random DNA mimics ENCODE-like 'functional' behavior. In response to some of the criticisms, other scientists argued that the wide spread transcription and splicing that is observed in the human genome directly by biochemical testing is a more accurate indicator of genetic function than genomic conservation estimates because conservation estimates are all relative and difficult to align due to incredible variations in genome sizes of even closely related species, it is partially tautological, and these estimates are not based on direct testing for functionality on the genome.

One study suggested that 15% of the world's women might have the type of fourth cone whose sensitivity peak is between the standard red and green cones, giving, theoretically, a significant increase in color differentiation. Another study suggests that as many as 50% of women and 8% of men may have four photopigments and corresponding increased chromatic discrimination compared to trichromats. In 2010, after twenty years of study of women with four types of cones (non-functional tetrachromats), neuroscientist Dr. Gabriele Jordan identified a woman (subject cDa29) who could detect a greater variety of colors than trichromats could, corresponding with a functional tetrachromat (or true tetrachromat).San Diego woman Concetta Antico diagnosed with 'super vision' Published on 22 Nov 2013 Variation in cone pigment genes is wide-spread in most human populations, but the most prevalent and pronounced tetrachromacy would derive from female carriers of major red/green pigment anomalies, usually classed as forms of "color blindness" (protanomaly or deuteranomaly).

By the 1980s, scientists (notably Aziz Sancar) had uncovered how NER works in bacteria but this pathway remained poorly understood in mammalian cells. Wood's first breakthrough came in 1988, after he moved to England to work at the Imperial Cancer Research Fund with Tomas Lindahl (Lindahl, Sancar and Paul Modrich later would receive the 2015 Nobel Prize in Chemistry for their contributions to DNA repair). Working in Lindahl's lab, Wood developed a way to perform NER on DNA in a test tube using crude cell-free extracts from tissues. By performing this test on extracts derived from blood cells of children with XP, Wood could begin deciphering which different proteins are involved in the NER process. Extracts from children with group A XP, for example, could be “complemented” to resume DNA repair by adding extracts from children with group C XP (who have a normal group A protein but a non-functional group C protein).

Gemini spacecraft on display at Air Force Space and Missile Museum, Cape Canaveral, Florida, October 15, 2004 The prototype Space Shuttle orbiter Enterprise in full boilerplate stack configuration with External Tank and SRBs ready to undergo vibration testing at the Marshall Space Flight Center, October 4, 1978 A boilerplate spacecraft, also known as a mass simulator, is a nonfunctional craft or payload that is used to test various configurations and basic size, load, and handling characteristics of rocket launch vehicles. It is far less expensive to build multiple, full-scale, non-functional boilerplate spacecraft than it is to develop the full system (design, test, redesign, and launch). In this way, boilerplate spacecraft allow components and aspects of cutting-edge aerospace projects to be tested while detailed contracts for the final project are being negotiated. These tests may be used to develop procedures for mating a spacecraft to its launch vehicle, emergency access and egress, maintenance support activities, and various transportation processes.

An underlying cause of the incident was that the signalling system now in use on the lines from Shrewsbury to Aberystwyth and Pwllheli did not interface with the automatic level crossings on these routes. The RAIB has made six recommendations, three directed to Network Rail, two to Arriva Trains Wales and one to the Rail Safety and Standards Board. These cover the development of engineering solutions to mitigate the risk of trains passing over automatic crossings which have not operated correctly; changes to the operating equipment of Llanbadarn crossing; the processes used by railway operators to request permission to deviate from published standards; the operational requirements of drivers as trains depart from Aberystwyth; and the way in which drivers interact with the information screens of the cab signalling used on the Cambrian lines. The failure at ERTMS System-User Interface investigated by the RAIB indicates that the ERTMS Implementation did not satisfy the non-functional attribute of safety integrity of the real time dependable distributed computing concepts.

Furthermore, Epic asserted the Canadian developer broke the contract when it employed this derivative work in an internal title and a second game with Sega, a partnership for which it never received a license fee. On May 30, 2012, Epic Games defeated Silicon Knights' lawsuit, and won its counter-suit for $4.45 million on grounds of copyright infringement, misappropriation of trade secrets, and breach of contract, an injury award that was later doubled due to prejudgment interest, attorneys' fees and costs. Consistent with Epic's counterclaims, the presiding judge, James C. Dever III, stated that Silicon Knights had "deliberately and repeatedly copied thousands of lines of Epic Games' copyrighted code, and then attempted to conceal its wrongdoing by removing Epic Games' copyright notices and by disguising Epic Games' copyrighted code as Silicon Knights' own". Dever stated that evidence against Silicon Knights was "overwhelming", as it not only copied functional code but also "non-functional, internal comments Epic Games' programmers had left for themselves".

This Is Spinal TapOfficially stylized as This Is Spin̈al Tap: A Rockumentary by Martin Di Bergi, with a non-functional heavy metal umlaut over the letter n --n-diaeresis--and a dotless letter i. (stylized as This Is Spın̈al Tap: A Rockumentary by Martin Di Bergi) is a 1984 American mockumentary film co- written and directed by Rob Reiner in his directorial debut. It stars Christopher Guest, Michael McKean, and Harry Shearer as members of the fictional English heavy metal band Spinal Tap (who are characterized as "one of England's loudest bands"), and Reiner as Martin "Marty" Di Bergi, a documentary filmmaker who follows them on their American tour. The film satirizes the behavior and musical pretensions of rock bands and the hagiographic tendencies of rock documentaries such as The Song Remains the Same (1976), and The Last Waltz (1978) and follows the similar All You Need Is Cash (1978) by The Rutles.

The Spectre paper displays the attack in four essential steps: # First, it shows that branch prediction logic in modern processors can be trained to reliably hit or miss based on the internal workings of a malicious program. # It then goes on to show that the subsequent difference between cache hits and misses can be reliably timed, so that what should have been a simple non-functional difference can in fact be subverted into a covert channel which extracts information from an unrelated process's inner workings. # Thirdly, the paper synthesizes the results with return-oriented programming exploits and other principles with a simple example program and a JavaScript snippet run under a sandboxing browser; in both cases, the entire address space of the victim process (i.e. the contents of a running program) is shown to be readable by simply exploiting speculative execution of conditional branches in code generated by a stock compiler or the JavaScript machinery present in an existing browser.

His orchestral idiom developed more gradually, reaching a new maturity in The Sea of 1911, which was to become his most popular and successful orchestral work , receiving frequent performances at the Henry Wood Promenade Concerts during his lifetime. In the period leading up to the First World War Bridge demonstrates an interest in more noticeably modernist tendencies, most notably in Dance Poem of 1913, which suggests the influence of Stravinsky and Debussy. During the war period, his exploration generally took more moderate forms – most often a pastoralism influenced by impressionism – although work such as the Two Poems for orchestra and several piano pieces display significant developments in his harmonic language, specifically towards a coloristic, non- functional use of harmony, and a preference for harmony derived from symmetrical scales such as whole tone and octatonic. During the same period Bridge completed two of his most successful chamber works, the Second String Quartet and Cello Sonata .

Marysville's historic water tower, located in Comeford Park The City of Marysville operates and maintains on 35 public recreational facilities within city limits, including parks, playgrounds, sports fields, nature preserves, community centers, a golf course and other facilities. Comeford Park, located in Downtown Marysville and named for town founders James P. Comeford and his wife Maria, is the city's oldest municipal park and is home to the city's landmark water tower, built in 1921 and non-functional since the 1970s. The water tower, originally accompanied by a second tower demolished in 1987, was planned in the late 1990s to be demolished, but was saved in 2002 after $500,000 was raised by the Marysville Historical Society to renovate and preserve the structure. The Comeford Park is also home to the Ken Baxter Community Center, a gazebo donated by the city's Rotary Club, a children's playground, and a spray park that opened in 2014.

Civilians The government in the resolution notifying its acceptance of the 7CPC in July 2016 decides to maintain the status quo on Non Functional Upgrade (NFU) admissible to all Organised Group ‘A’ Services, including defence civilians, even though there was no consensus in the commission for continuing with NFU. Two Members of the commission, in their dissent note, had said that "exclusion of Defense forces from NFU" by the UPA government was "unfair", and that Organised Group ‘A’ Services were guilty of recklessly de-linking "promotions from career progression", and that they are far less deserving than the officers of the Defence Forces. They recommended that NFU be abolished for all services. Armed forces Chairperson of 7CPC in his recommendations in the 7CPC report recommended that a watered down NFU with long residencies "be extended to the officers of the Defence forces and CAPFs" to "ameliorate the difficulties faced by the officers owing to stagnation at various levels".

They also disclosed that Cooper chose the older of the two primary parachutes supplied to him, rather than the technically superior professional sport parachute; and that from the two reserve parachutes, he selected a "dummy"—an unusable unit with an inoperative ripcord intended for classroom demonstrations, although it had clear markings identifying it to any experienced skydiver as non- functional. (He cannibalized the other, functional reserve parachute, possibly using its shrouds to tie the money bag shut, and to secure the bag to his body as witnessed by Mucklow.) The FBI stressed that inclusion of the dummy reserve parachute, one of four obtained in haste from a Seattle skydiving school, was accidental. In March 2009, the FBI disclosed that Tom Kaye, a paleontologist from the Burke Museum of Natural History and Culture in Seattle, had assembled a team of "citizen sleuths", including scientific illustrator Carol Abraczinskas and metallurgist Alan Stone. The group, eventually known as the Cooper Research Team, reinvestigated important components of the case using GPS, satellite imagery, and other technologies unavailable in 1971.

Second, the editing pattern controls the amount of the 5-HT2CR mRNA that leads to the expression of full-length protein through the modulation of alternative splice site selection 76,77. Among three alternative splice donor sites (GU1 to GU3; Fig. 4C), GU2 is the only site that forms the mature mRNA to produce the functional, full-length 5-HT2CR protein. Unedited pre-mRNAs tend to be spliced at the GU1 site, resulting in the truncated, non-functional protein if translated 76,77. However, most pre-mRNAs edited at more than one position are spliced at GU2 77. Thus, when editing is inefficient, increased splicing at GU1 may act as a control mechanism to decrease biosynthesis of the 5-HT2CR-INI and thereby limit serotonin response. Third, RNA editing controls the ultimate physiological output of constitutively active receptors by affecting the cell surface expression of the 5-HT2CR. The 5-HT2CR-VGV, which displays the lowest level of constitutive activity, is fully expressed at the cell surface under basal conditions and is rapidly internalized in the presence of agonist 78.

"I never got the idea that he was particularly interested", states Lambert to Ripley (the scene does appear in the novelization). Loughlin observes that this is suggestive of homosexuality on Ash's part, although his true nature is revealed when he attempts to kill Ripley with the pornographic magazine; an act which is both an echo of the way that the alien "facehugger" infests its victims, and a sexual symbol of phallic penetration and rape by an android that, even if it did have a phallus (which is not specified in the film), would probably have been sexually non-functional. Thompson relates the assertion, echoed by Gallardo and Smith, that Ash's use of the pornographic magazine against Ripley "relat[es] pornography to violence against women", but disputes it, stating that this analyses the scene by itself, without taking into account the larger context of the rest of the film. Thompson points out that this is a clumsy and inefficient way to attempt to kill Ripley, as evidenced not the least by the fact that it takes long enough that other characters are able to turn up on the scene and intervene.

Over the decades, the completely new advances presented in the 2000-series cars for the time presented maintenance problems in the future; the aluminum bodies rusted quickly in the Chicago winters, while snow caused motors to short out and brakes to become non-functional (especially after the 1979 blizzard). The 2200-series cars, originally meant as complements to the 2000-series cars, were much more durable on the L's busier lines, while the 2000-series cars were moved to the older lines with less frequency. The 2200-series construction, with a flat sided stainless steel body, under-car air conditioning units (as opposed to the 2000s interior units), and more capable Budd Pioneer motors all contributed to the much longer lifespan of the 2200-series over the 2000-series; the final blow came when the Green Line closed for renovation, as the 2000-series were not considered capable enough for Red or Blue Line service. The last 2000-series cars were scrapped after their final service on the Green Line on December 17, 1993, ending with 29 years of service. One pair of cars is preserved, 2153-2154 is preserved at the Illinois Railway Museum in Union, Illinois.

As the server must have individually subscribed smart cards for each channel to be viewed, its continued operation tends to be costly and may require multiple subscriptions under different names and addresses. There is also a risk that as the number of card clients on the card sharing network grows, it will attract the attention of the satellite TV service provider and law enforcement agencies and the monitoring of IP addresses associated with this card sharing network may identify individual users and server operators who then become targets for legal action by the satellite TV service provider or by legal authorities. Key sharing schemes are typically used where replacement of compromised smart card systems (such as the deprecation of Nagra 1/2 in favour of Nagra 3) has made other pirate decryption methods non-functional. In February 2014, an episode of BBC's "Inside Out" disclosed that the complete Sky TV package could be obtained from black-market sources for as little as £10 per month through Internet key sharing, Swansea and Cardiff were highlighted with significant activity in pubs using cracked boxes to show Premier League football.