Long hours crouched over a microscope, combined with Cajal's self-described "irresistible mania for scribbling," resulted in hundreds of detailed sketches of neurons, neuroglia, and all the other goop in our skulls.
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Lage agrees but adds: What's next: Geschwind says testing on a larger sample is needed, and in particular, he would like to examine closer the role of neuroglia like microglia and astrocytes.
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In a series of highly cited conceptual reviews he outlined basic principles of glial physiology and pathophysiology, which significantly influenced this rapidly developing area of neuroscience. Working with Arthur Butt, Verkhratsky published two textbooks on physiology and pathophysiology of neuroglia in 2007 and 2013 and have been the only didactic writings on neuroglia.
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Nervous tissue is composed of neurons, also called nerve cells, and neuroglial cells. Four types of neuroglia found in the CNS are astrocytes, microglial cells, ependymal cells, and oligodendrocytes. Two types of neuroglia found in the PNS are satellite cells and Schwann cells. In the central nervous system (CNS), the tissue types found are grey matter and white matter.
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Within the CNS, the interneuronal space is filled with a large amount of supporting non- nervous cells called neuroglia or glia from the Greek for "glue".
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MDA produces serotonergic neurotoxic effects, thought to be activated by initial metabolism of MDA. In addition, MDA activates a response of the neuroglia, though this subsides after use.
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In the cerebral cortex the large neuron cell bodies, such as Betz cells, are separated by a considerable distance. Of additional importance are the neuroglia which are the supporting cells and consist of astrocytes, oligodendroglia, and microglia. These cells permeate and support the nervous tissue of the CNS, binding it together like a scaffold that also supports the vasculature. The most numerous of the neuroglia are Type I astrocytes, which make up about half the brain, greatly outnumbering the neurons.
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The posterior median sulcus is the posterior end of the posterior median septum of neuroglia of the spinal cord. The septum varies in depth from 4 to 6 mm, but diminishes considerably in the lower part of the spinal cord.
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The apex of the posterior grey column, one of the three grey columns of the spinal cord, is capped by a V-shaped or crescentic mass of translucent, gelatinous neuroglia, termed the substantia gelatinosa of Rolando (or SGR) (or gelatinous substance of posterior horn of spinal cord), which contains both neuroglia cells, and small nerve cells. The gelatinous appearance is due to a very low concentration of myelinated fibers. It extends the entire length of the spinal cord and into the medulla oblongata where it becomes the spinal nucleus of the trigeminal nerve. It is named after Luigi Rolando.
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A glioblast is a type of cell derived from neuroectoderm and with the ability to differentiate into several different types of neuroglia. It comes from a precursor (spongioblast). However, the latter may also differentiate into an ependymoblast. Glioblasts differentiate into astrocytes and oligodendrocytes.
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The pathway allows sensory information to reach the hippocampus for encoding. The mossy fiber pathway itself projects to CA3. Repetitive stimulation of its neurons leads to progressive use-dependent synaptic depression. These short-term changes in plasticity have been shown to be mediated by sodium channels that receive input from neuroglia.
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Müller also described the fibers of neuroglia cells that make up the supporting framework of the retina. This structure was to become known as "Müller's fibers". In 1856, with his colleague Albert von Kölliker (1817–1905), he showed that an electric current was produced from each contraction of a frog's heart.
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There is tentative research that suggests that pioglitazone may be useful for treating major depression. Because it is thought to reduce inflammatory activity in neuroglia, it was studied in a small clinical trial involving children with autism, under the autoimmune/inflammatory hypotheses of the causes of autism. Pioglitazone may improve symptoms of psoriasis.
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As part of a group of disorders known as leukodystrophies, Krabbe disease results from the imperfect growth and development of myelin. Galactosylceramidase deficiency also results in a buildup of a glycosphingolipid called psychosine, which is toxic to oligodendrocytes, a type of non-neuronal cell found in the nervous system, collectively termed neuroglia.
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Glia is a Monthly peer reviewed scientific journal covering research on the structure and function of neuroglia. It was established in 1988 and is published by John Wiley & Sons. The founding and current editors-in-chief are Bruce R. Ransom (University of Washington School of Medicine) and Helmut Kettenmann (Max Delbrück Center for Molecular Medicine).
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She has developed approaches to image neurons and inner ear sensory cells with the scanning electron microscopy and transmission electron microscopy and in vivo, primarily using multi-photon microscopy., as well as using high throughput methods such as RNA-Seq and microarrays to study genes expressed in the inner ear and cell cultures of neuroglia.
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The ependyma is the thin neuroepithelial lining of the ventricular system of the brain and the central canal of the spinal cord. The ependyma is one of the four types of neuroglia in the central nervous system (CNS). It is involved in the production of cerebrospinal fluid (CSF), and is shown to serve as a reservoir for neuroregeneration.
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In 1873 he was appointed director of the marine zoology laboratory at Concarneau. Robin's contributions to medical science were many and varied. He was among the first scientists in France to use the microscope in normal and pathological anatomy. He was the first to describe the species Candida albicans (a diploid fungus), and he contributed new information on the micro-structure of ganglia and of neuroglia.
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Serrano joined New Mexico State University in 1992, where she established NMSU's first neuroscience research laboratory. Serrano was selected as a Regents Professor in 2009. Her research considers the ear, hearing and balance,as well as the role of neuroglia in brain function. She has studied the transduction of light by plant stomata and the formation of sensory organs, and the ways sensory cells acquire their phenotypes.
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In more severely affected cells, the separation between the cytoplasm and nucleus diminishes significantly, causing the cytoplasm to become even more dense and have an increase in electron density. Neuroglia cells are only affected in severe cases. They fill in the spaces that have been diminished due to the loss or atrophy of the dendritic terminals. Astrocytes and microglia cells digest the decaying organelles and dying neurons through phagocytosis.
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There is an upregulation of this SUR1/ TRPM4 nonselective cation channel followed by brain tumor, ischemic injury, and traumatic brain injury. This channel which is activated by ATP depletion is found on neurons, neuroglia and endothelium. This channel enables the passive transport of water and solute and represents the ATP independent stage of cerebral formation. Opening of these channels result in cellular depolarization and blebbing causing cytotoxic edema.
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Basic transport of glutamate in the synapse as well as the neuroglia. Glutamate transporters are proficient at pumping glutamate into cells due to their ability to couple with inorganic ions. Transport of glutamate into the cell requires the coupling of three sodium ions as well as a proton, whereas transport out of the cell requires a single potassium ion. This transport results in two positive charges being displaced across the membrane per cycle.
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EP2 deficient mice exhibit reduced Oxidative stress and beta amyloid formation. Activation of this receptor also has neuroprotective effects in models of Alzheimer's disease, Amyotrophic lateral sclerosis, multiple sclerosis, and stroke while its inhibition reduces Epileptic seizure. EP2 receptors that are located on either nerve or Neuroglia cells of the peripheral and central nervous system act to promote pain perception caused by inflammation, muscle stretch, temperature, and physical stimuli (see allodynia) in mice.
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Eventually Palay returned to Yale, where he was appointed first as an Instructor and then as an Assistant Professor of Anatomy, where he remained until his appointment as Chief of Neurocytology at the National Institutes of Health (NIH) in Bethesda, Maryland. Later, he was promoted to the position of Chief of the Laboratory of Neuroanatomical Science, and while he was at the NIH, he continued his work on the ultrastructure of synapses, as well as studying neurosecretion and neuroglia.
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HB-EGF is recognized as an important component for the modulation of cell activity in various biological interactions. Found widely distributed in cerebral neurons and neuroglia, HB-EGF induced by brain hypoxia and or ischemia subsequently stimulates neurogenesis. Interactions between uterine HB-EGF and epidermal growth factor receptors of blastocysts influence embryo- uterine interactions and implantation. Studies show HB-EGF protects intestinal stem cells and intestinal epithelial cells in necrotizing enterocolitis, a disease affecting premature newborns.
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A recently discovered and understood cytokine is currently being used to try to treat the axotomy before the rise in pressure occurs. This cytokine, called osteopontin, may be able to aid in axon regeneration by exposing its integrin receptor binding sites. Osteopontin secretion may be able to regulate synaptogenesis and target the necessary neuroglia required for the repair of the axons. A study done by Julie L. Chan proves the functionality of osteopontin in initiating the immune response necessary for synaptic repair and reorganization after injury (axotomy).
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Muscle is stained blue-black to dark brown, connective tissue is pale orange-pink to brownish red, fibrin and neuroglia stain deep blue, coarse elastic fibers show as purple, and bone and cartilage obtain yellowish to brownish red color. PTAH is ideal for demonstrating striated muscle fibers and mitochondria, often without a counterstain. As such, it is used to identify contraction bands, as seen in contraction band necrosis. PTAH stains ependymomas while it does not stain choroid plexus papillomas, providing one means of differentiating these tumors.
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Neuroglia of the brain shown by Golgi's method Olfactory ensheathing cells (OECs), also known as olfactory ensheathing glia or olfactory ensheathing glial cells, are a type of macroglia (radial glia) found in the nervous system. They are also known as olfactory Schwann cells, because they ensheath the non-myelinated axons of olfactory neurons in a similar way to which Schwann cells ensheath non-myelinated peripheral neurons. They also share the property of assisting axonal regeneration. OECs are capable of phagocytosing axonal debris in vivo, and in vitro they phagocytose bacteria.
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The latter is published by German Anthropological Association and the Berlin Society for Anthropology, Ethnology and Prehistory, the societies which he also founded. Virchow was the first to describe and christen diseases such as leukemia, chordoma, ochronosis, embolism, and thrombosis. He coined biological terms such as "chromatin", "neuroglia", "agenesis", "parenchyma", "osteoid", "amyloid degeneration", and "spina bifida"; terms such as Virchow's node, Virchow–Robin spaces, Virchow–Seckel syndrome, and Virchow's triad are named after him. His description of the life cycle of a roundworm Trichinella spiralis influenced the practice of meat inspection.
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Oligodendrocytes (), or oligodendroglia, are a type of neuroglia whose main functions are to provide support and insulation to axons in the central nervous system of some vertebrates, equivalent to the function performed by Schwann cells in the peripheral nervous system. Oligodendrocytes do this by creating the myelin sheath. A single oligodendrocyte can extend its processes to 50 axons, wrapping approximately 1 μm of myelin sheath around each axon; Schwann cells, on the other hand, can wrap around only one axon. Each oligodendrocyte forms one segment of myelin for several adjacent axons.
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The dentate gyrus receives excitatory projections from neurons in layer II of the entorhinal cortex as well as input from surrounding neuroglia. The unmyelinated granule cell axons of the mossy fiber pathway express both GABA receptors and glutamate receptors along their membranes that allow them to be modulated by both excitatory and inhibitory input from nearby glial cells. Axons from the entorhinal cortex synapse primarily on the dendritic spines of outer layer dentate granule cells. The entorhinal cortex passes sensory information from neocortical structures to the hippocampal formation.
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Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans The neurotrophic factors – nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NTF3) are also involved in axon development and bind to Trk receptors. The ganglioside-converting enzyme plasma membrane ganglioside sialidase (PMGS), which is involved in the activation of TrkA at the tip of neutrites, is required for the elongation of axons. PMGS asymmetrically distributes to the tip of the neurite that is destined to become the future axon.
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Neurons generate electrical signals that travel along their axons. When a pulse of electricity reaches a junction called a synapse, it causes a neurotransmitter chemical to be released, which binds to receptors on other cells and thereby alters their electrical activity. The brains of all species are composed primarily of two broad classes of cells: neurons and glial cells. Glial cells (also known as glia or neuroglia) come in several types, and perform a number of critical functions, including structural support, metabolic support, insulation, and guidance of development.
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Neoplastic glial cells stained with an antibody against GFAP (brown), from a brain biopsy While glial cells in the PNS frequently assist in regeneration of lost neural functioning, loss of neurons in the CNS does not result in a similar reaction from neuroglia. In the CNS, regrowth will only happen if the trauma was mild, and not severe. When severe trauma presents itself, the survival of the remaining neurons becomes the optimal solution. However, some studies investigating the role of glial cells in Alzheimer's disease are beginning to contradict the usefulness of this feature, and even claim it can "exacerbate" the disease.
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The glia limitans, or the glial limiting membrane, is a thin barrier of astrocyte foot processes associated with the parenchymal basal lamina surrounding the brain and spinal cord. It is the outermost layer of neural tissue, and among its responsibilities is the prevention of the over migration of neurons and neuroglia, the supporting cells of the nervous system, into the meninges. The glia limitans also plays an important role in regulating the movement of small molecules and cells into the brain parenchyma by working in concert with other components of the central nervous system (CNS) such as the blood–brain barrier (BBB).
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Perisynaptic schwann cells (also known as Terminal schwann cells or Teloglia) are Neuroglia found at the Neuromuscular junction (NMJ) with known functions in synaptic transmission, synaptogenesis, and nerve regeneration. These cells share a common ancestor with both Myelinating and Non-Myelinating Schwann Cells called Neural Crest cells. Perisynaptic Schwann Cells (PSCs) contribute to the tripartite synapse organization in combination with the pre-synaptic nerve and the post-synaptic muscle fiber. PSCs are considered to be the glial component of the Neuromuscular Junction (NMJ) and have a similar functionality to that of Astrocytes in the Central Nervous System.
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Dissection of human embryo The cephalic end of the neural groove exhibits several dilatations that, when the tube is closed, assume the form of the three primary brain vesicles, and correspond, respectively, to the future forebrain (prosencephalon), midbrain (mesencephalon), and hindbrain (rhombencephalon) (Fig. 18). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the spinal cord (medulla spinalis); from its ectodermal wall the nervous and neuroglial elements of the spinal cord are developed, while the cavity persists as the central canal.
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In his long activity as a psychiatrist and neurologist, Cerletti published 113 original papers, about the pathology of senile plaques in Alzheimer's disease, on the structure of neuroglia, the blood–brain barrier, syphilis, etc. In 1950 he received an honorary degree by the Collège de Sorbonne at the University of Paris, in addition to a long list of other awards and degrees. Away from his medical work, Cerletti is credited with introducing the idea of white uniforms for alpine troops in order to reduce visibility during the First World War. He also invented artillery missiles with delayed-action fuses.
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Glia, also called glial cells or neuroglia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system that do not produce electrical impulses. They maintain homeostasis, form myelin, and provide support and protection for neurons. In the central nervous system, glial cells include oligodendrocytes, astrocytes, ependymal cells, and microglia, and in the peripheral nervous system glial cells include Schwann cells and satellite cells. They have four main functions: (1) to surround neurons and hold them in place; (2) to supply nutrients and oxygen to neurons; (3) to insulate one neuron from another; (4) to destroy pathogens and remove dead neurons.
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Nervous tissue, also called neural tissue, is the main tissue component of the nervous system. The nervous system regulates and controls bodily functions and activity and consists of two parts: the central nervous system (CNS) comprising the brain and spinal cord, and the peripheral nervous system (PNS) comprising the branching peripheral nerves. It is composed of neurons, also known as nerve cells, which receive and transmit impulses, and neuroglia, also known as glial cells or glia, which assist the propagation of the nerve impulse as well as provide nutrients to the neurons. Nervous tissue is made up of different types of neurons, all of which have an axon.
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Alexei Verkhratsky, (, ) sometimes spelled Alexej, is a professor of neurophysiology at the University of Manchester best known for his research on the physiology and pathophysiology of neuroglia, calcium signalling, and brain ageing. He is an elected member and vice-president of Academia Europaea, of the German National Academy of Sciences Leopoldina, of the Real Academia Nacional de Farmacia (Spain), of the Slovenian Academy of Sciences and Arts, of Polish Academy of Sciences, and Dana Alliance for Brain Initiatives, among others. Since 2010. he is a Ikerbasque Research Professor and from 2012 he is deputy director of the Achucarro Basque Center for Neuroscience in Bilbao.
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Dorsal roots and ventral roots come together and exit the intervertebral foramina as they become spinal nerves. The gray matter, in the center of the cord, is shaped like a butterfly and consists of cell bodies of interneurons and motor neurons. It also consists of neuroglia cells and unmyelinated axons. Projections of the gray matter (the “wings”) are called horns. Together, the gray horns and the gray commissure form the “gray H.” The white matter is located outside of the gray matter and consists almost totally of myelinated motor and sensory axons. “Columns” of white matter carry information either up or down the spinal cord.
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Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind- brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles.
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Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia or polydendrocytes, are a subtype of glial cells in the central nervous system. They are process-bearing glial cells (neuroglia) in the mammalian central nervous system (CNS) that are identified by the expression of the NG2 chondroitin sulfate proteoglycan (CSPG4) Ensembl genome browser 68: Homo sapiens - Result in Detail - Ensembl Lucene search and the alpha receptor for platelet-derived growth factor (PDGFRA).Ensembl genome browser 68: Homo sapiens - Result in Detail - Ensembl Lucene search They are precursors to oligodendrocytes and may also be able to differentiate into neurons and astrocytes. Differentiated oligodendrocytes support axons and provide electrical insulation in the form of a myelin sheath, enabling faster action potential propagation and high fidelity transmission without a need for an increase in axonal diameter.
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Common causes of scotomata include demyelinating disease such as multiple sclerosis (retrobulbar neuritis), damage to nerve fiber layer in the retina (seen as cotton wool spots"The role of axoplasmic transport in the pathogenesis of retinal cotton-wool spots", D. McLeod, J. Marshall, E. M. Kohner, and A. C. Bird, Br J Ophthalmol (1977), 61(3), pages 177–191.) due to hypertension, toxic substances such as methyl alcohol, ethambutol and quinine, nutritional deficiencies, vascular blockages either in the retina or in the optic nerve, stroke or other brain injury, and macular degeneration, often associated with aging. Scintillating scotoma is a common visual aura in migraine."Possible Roles of Vertebrate Neuroglia in Potassium Dynamics, Spreading depression, and migraine", Gardner-Medwin, J. Exp. Biol. (1981), 95, pages 111-127 (Figure 4).
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Neuroglia retain the capability of cell division in contrast to neurons and, therefore, the responses to radiation differ between the cell types. A third type of tissue in the brain is the vasculature which exhibits a comparable vulnerability for radiation damage to that found elsewhere in the body. Radiation-induced damage to oligodendrocytes and endothelial cells of the vasculature accounts for major aspects of the pathogenesis of brain damage that can occur after high doses of low-LET radiation.” Based on studies with low-LET radiation, the CNS is considered a radioresistant tissue. For example: in radiotherapy, early brain complications in adults usually do not develop if daily fractions of 2 Gy or less are administered with a total dose of up to 50 Gy. The tolerance dose in the CNS, as with other tissues, depends on the volume and the specific anatomical location in the human brain that is irradiated.
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The effects of irradiation on the SVZ provided for a recognition of the amount or dose of radiation that can be given is determined mostly by the tolerance of the normal cells near the tumor. As described, the increasing dose of radiation and age led to decrease in three cell types of the SVZ, yet repair capacity of the SVZ was observed despite the lack of white matter necrosis; this occurred likely because the SVZ was able to gradually replace the neuroglia of the brain. Chemotherapeutics were also tested for their effects on the SVZ, as they are currently used for many diseases yet lead to complications within the central nervous system. To do so, methotrexate (MTX) was used alone and in combination with radiation to find that roughly 70% of the total nuclear density of the SVZ had been depleted, yet given loss of neuroblast cells (progenitor cells), it was remarkable to find that SVZ NSCs would still generate neurospheres similar to subjects that did not receive such treatment.
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