Full of honest, unbridled joy, bounding around a club, euphoria spilling out of every nerve ending.
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We've got this nerve ending we've looked at and we don't know if it's involved in sexual sensation.
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I thought maybe some nerve ending in my thigh had become so habituated to the vibration that it had gone into permanent iPhone spasm.
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When I am sick, I feel like every nerve ending in my body has been set on fire and is constantly communicating danger, panic, and alarm.
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It was pure, and I mean pure pain, like being plugged into the light socket of all that is—a raw nerve ending of the universe.
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But as played by Minnette, TV Clay is a likably awkward loner who slowly frays into a single raw nerve ending over the course of the show.
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For what Ms. Piper achieves is an anatomy of an obsession that, layer by layer, peels off one woman's skin until every nerve ending is mercilessly exposed.
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Gunter said it's likely that Gräfenberg misconstrued other parts of a woman's genitals, like the nerve ending-packed clitoris, as this seemingly new discovery of the G-spot.
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The reason why sunburn itches like this isn't entirely known, but Dr. Feely says it's likely a side effect of nerve ending injuries that happen on the skin when you get a bad sunburn.
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Human eyeballs and the PGA Tour's computers verify that Spieth isn't converting on the putting greens as often as he did 221-220 months ago, when he seemingly didn't have a jangling nerve ending anywhere in his body.
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Dr. Lee sits Taylor down and explains that the bump between her butt cheeks is a condition called spinal dysraphism, a condition that occurs when a baby's spinal cord doesn't fuse all the way, leaving a nubby nerve ending which pops out around the bottom.
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If an exposed nerve ending could walk, talk and attend high school, it would surely resemble the title character of the terrific musical "Dear Evan Hansen," about a friendless 17-year-old played with such prickly authenticity by the wonderful Ben Platt that you can practically feel his flop sweat on your own brow.
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The second neuron in the figure depicts an encapsulated nerve ending.
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A free nerve ending (FNE) or bare nerve ending, is an unspecialized, afferent nerve fiber sending its signal to a sensory neuron. Afferent in this case means bringing information from the body's periphery toward the brain. They function as cutaneous nociceptors and are essentially used by vertebrates to detect noxious stimuli that often result in pain.
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The discoid nerve ending can also be seen to contain clear vesicles and some dense-core vesicles. Thinner nerve fibers lacking myelin sheaths can also be observed just outside the capsule.
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The distal section of the axon may either be a bare nerve ending or encapsulated by a structure that helps relay specific information to nerve. Two examples where the nerve ending of the distal process is encapsulated as such are, Meissner's corpuscles, which render the distal processes of mechanosensory neurons sensitive to stroking only, and Pacinian corpuscles, which make neurons more sensitive to vibration.Kandel ER, Schwartz JH, Jessell TM. Principles of Neural Science, 4th ed., p.431–433.
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Mechanosensory free nerve endings detect touch, pressure, stretching, as well as the tickle and itch sensations. Itch sensations are caused by stimulation of free nerve ending from chemicals. Baroreceptors are a type of mechanoreceptor sensory neuron that is excited by stretch of the blood vessel.
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Free nerve endings are unencapsulated and have no complex sensory structures. They are the most common type of nerve ending, and are most frequently found in the skin. They mostly resemble the fine roots of a plant. They penetrate the dermis and end in the stratum granulosum.
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The frequencies of the impulses decrease quickly and soon stop due to the relaxation of the inner layers of connective tissue that cover the nerve ending. This adaptation is useful, as it stops the nervous system from being overloaded with unnecessary information such as the pressure exerted by clothing.
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The presynaptic regulation of the dorsal nerve ending discharge in the spinal cord can occur through certain types of GABAA receptors but not through the activation of glycine receptors which are absent from these types of terminals. Thus GABAA receptors but not glycine receptors can presynaptically control nociception and pain transmission.
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3 (September 12). . Pacinian corpuscles cause action potentials when the skin is rapidly indented but not when the pressure is steady, due to the layers of connective tissue that cover the nerve ending. It is thought that they respond to high-velocity changes in joint position. They have also been implicated in detecting the location of touch sensations on handheld tools.
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Figure 1. Biological pathway of penile erection Penile erection is a hemodynamic event in the smooth muscle of corpus cavernous. PDE5 is the main cGMP hydrolysing enzyme found in penile corpus cavernous. Erection is triggered by release of the neurotransmitter nitric oxide (NO) from non- adrenergic and non-cholinergic neurons from nerve ending in the penis as well as from endothelial cells.
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Tactile corpuscles or Meissner's corpuscles are a type of mechanoreceptor discovered by anatomist Georg Meissner (1829–1905) and Rudolf Wagner. They are a type of nerve ending in the skin that is responsible for sensitivity to light touch. In particular, they have their highest sensitivity (lowest threshold) when sensing vibrations between 10 and 50 hertz. They are rapidly adaptive receptors.
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It transmitted electric currents into GABA, an acid. A lack of GABA in the body is a factor in chronic pain. GABA would then be dispersed properly to the damaged nerves, acting as a painkiller. Vagus Nerve Stimulation (VNS) is used to activate the Cholinergic Anti-inflammatory Pathway (CAP) in the Vagus Nerve, ending in reduced inflammation in patients with diseases like arthritis.
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See 133–135 for orgasm information, and page 76 for G-spot and vaginal nerve ending information. For women, the most common way to achieve orgasm is by direct sexual stimulation of the clitoris (meaning consistent manual, oral or other concentrated friction against the external parts of the clitoris). General statistics indicate that 70–80% of women require direct clitoral stimulation to achieve orgasm.
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Thermal nociceptors are activated by noxious heat or cold at various temperatures. There are specific nociceptor transducers that are responsible for how and if the specific nerve ending responds to the thermal stimulus. The first to be discovered was TRPV1, and it has a threshold that coincides with the heat pain temperature of 43 °C. Other temperature in the warm–hot range is mediated by more than one TRP channel.
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Among all these mechanoreceptors Pacinian corpuscle offers the highest sensitivity to high frequency vibration starting from few 10s of Hz to a few kHz with the help of its specialized mechanotransduction mechanism. There have been two different types of stimulators: electrotactile or vibrotactile. Electrotactile stimulators use direct electrical stimulation of the nerve ending in the skin to initiate the action potentials; the sensation triggered, burn, itch, pain, pressure etc. depends on the stimulating voltage.
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The song was written by the band's frontman Frederick Macpherson. The song has been reviewed by Boost the Music and NME, with the track coming #15 in NME's top 50 best tracks of 2011 and being described by the magazine as "A healthy, grandiose indie single, with hooks as sharp and nagging as a No 2 drill to a nerve ending, and as lush as an afternoon on laughing gas." A remix EP was released 24 August, 2012.
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Worrell finished the inning without allowing a run to score, then pitched a scoreless tenth, becoming the winner when Tom Pagnozzi had an RBI single in the bottom of the tenth to give the Cardinals a 4–3 victory. Through July 14, his ERA was 1.14. On September 4, Worrell was pitching for his 127th career save, which would have tied him with Bruce Sutter for the Cardinals' career record. While making a pitch, he injured his ulnar nerve, ending his season.
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Instead, neurotransmitters are recaptured ("reuptake") by the pre-synaptic nerve ending, and recycled for later transmissions. He theorized that epinephrine is held in tissues in an inactive form and is liberated by the nervous system when needed. This research laid the groundwork for later selective serotonin reuptake inhibitors (SSRIs), such as Prozac, which block the reuptake of another neurotransmitter, serotonin. In 1958, Axelrod also discovered and characterized the enzyme catechol-O-methyl transferase, which is involved in the breakdown of catecholamines.
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As the basilar membrane moves upward, the cilia move in the direction causing opening of the mechanically gated potassium channel. The influx of potassium ions leads to depolarization. On the contrary, the cilia move the other way as the basilar membrane moves down, closing more mechanically gated potassium channels and leading to hyperpolarization. Depolarization will open the voltage gated calcium channel, releasing neurotransmitter (glutamate) at the nerve ending, acting on the spiral ganglion cell, the primary auditory neurons, making them more likely to spike.
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Balshaw, confused by what he had just heard decided to try it. He started riding at Brockton Court Riding for the Disabled Association Group. At the age of 10, Balshaw was the seventh person in Europe to be selected for a state-of- the-art operation on his spinal cord. The procedure involved opening his back up and then artificially stimulating each nerve ending to see which made the worst results on his muscles and, in theory, to see which muscles were working against him.
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The distribution of the sensory neurons within the skin accounts for the large and overlapping receptive fields of the skin. The size of the receptive fields in turn explains why almost any given stimulus to the human skin can potentially activate a very large number of nerve terminals. Therefore, it is more likely that a stimulus caused by the prick of a needle be detected by more than a hundred nerve endings all sharing the same receptive field, than for that same needle prick to be detected by only one nerve ending.
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In LEMS, antibodies against VGCC, particularly the P/Q-type VGCC, decrease the amount of calcium that can enter the nerve ending, hence less acetylcholine can be released from the neuromuscular junction. Apart from skeletal muscle, the autonomic nervous system also requires acetylcholine neurotransmission; this explains the occurrence of autonomic symptoms in LEMS. P/Q voltage-gated calcium channels are also found in the cerebellum, explaining why some experience problems with coordination. The antibodies bind particularly to the part of the receptor known as the "domain III S5–S6 linker peptide".
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Orgasm (from Greek ὀργασμός orgasmos "excitement, swelling"; also sexual climax) is the sudden discharge of accumulated sexual excitement during the sexual response cycle, resulting in rhythmic muscular contractions in the pelvic region characterized by sexual pleasure.See 133–135 for orgasm information, and page 76 for G-spot and vaginal nerve ending information. Experienced by males and females, orgasms are controlled by the involuntary or autonomic nervous system. They are usually associated with involuntary actions, including muscular spasms in multiple areas of the body, a general euphoric sensation and, frequently, body movements and vocalizations.
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Venous access problems can cause bruising, referred to as a hematoma. While donating, a supply of calcium antacid tablets is usually kept close by to replenish the calcium lost. Because the anticoagulant works by binding to the calcium in the blood, a donor's levels of calcium – and especially of active calcium ions – drop during the donation process. The lips may begin to tingle or there may be a metallic taste; since calcium enables the function of the nervous system, nerve-ending-dense areas (such as the lips) are susceptible, at least during the donation process.
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In normal neuromuscular function, a nerve impulse is carried down the axon (the long projection of a nerve cell) from the spinal cord. At the nerve ending in the neuromuscular junction, where the impulse is transferred to the muscle cell, the nerve impulse leads to the opening of voltage-gated calcium channels (VGCC), the influx of calcium ions into the nerve terminal, and the calcium-dependent triggering of synaptic vesicle fusion with plasma membrane. These synaptic vesicles contain acetylcholine, which is released into the synaptic cleft and stimulates the acetylcholine receptors on the muscle. The muscle then contracts.
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The G-spot, also called the Gräfenberg spot (for German gynecologist Ernst Gräfenberg), is characterized as an erogenous area of the vagina that, when stimulated, may lead to strong sexual arousal, powerful orgasms and potential female ejaculation.See page 135 for prostate information, and page 76 for G-spot and vaginal nerve ending information. It is typically reported to be located up the front (anterior) vaginal wall between the vaginal opening and the urethra and is a sensitive area that may be part of the female prostate. The existence of the G-spot has not been proven, nor has the source of female ejaculation.
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Analyzing the plant’s homeostatic conditions and implementing it in the experiment, the researchers exposed parts of the pollen tube that were either the whole cell or the growing tip to see how growth occurs in response to an external field. The pollen tube serves as a useful model because it is similar to a nerve ending which conducts electrical signaling in humans and animals. Using the tip as a place for growth allows the cell to invade a substrate and for tropism. The experiment that the researchers conducted to support their hypothesis was that they suspended Camellia japonica pollen into an electrical field.
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The 30 nanometer cleft between nerve ending and endplate contains a meshwork of acetylcholinesterase (AChE) at a density of 2,600 enzyme molecules/micrometer2, held in place by the structural proteins dystrophin and rapsyn. Also present is the receptor tyrosine kinase protein MuSK, a signaling protein involved in the development of the neuromuscular junction, which is also held in place by rapsyn. About once every second in a resting junction randomly one of the synaptic vesicles fuses with the presynaptic neuron's cell membrane in a process mediated by SNARE proteins. Fusion results in the emptying of the vesicle's contents of 7000–10,000 acetylcholine molecules into the synaptic cleft, a process known as exocytosis.
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The cells that interpret information about the environment can be either (1) a neuron that has a free nerve ending, with dendrites embedded in tissue that would receive a sensation; (2) a neuron that has an encapsulated ending in which the sensory nerve endings are encapsulated in connective tissue that enhances their sensitivity; or (3) a specialized receptor cell, which has distinct structural components that interpret a specific type of stimulus. The pain and temperature receptors in the dermis of the skin are examples of neurons that have free nerve endings (1). Also located in the dermis of the skin are lamellated corpuscles, neurons with encapsulated nerve endings that respond to pressure and touch (2). The cells in the retina that respond to light stimuli are an example of a specialized receptor (3), a photoreceptor.
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G-Spot tornado was released at the time when the RIAA introduced the Parental Advisory, and therefore the discs were forced to have a parental advisory even when none of the album's tracks had lyrics, but rather due to the song's title which mentioned the G-spot, the female erogenous zone, an area of the vagina that when stimulated, may lead to strong sexual arousal, powerful orgasms and potential female ejaculation.See page 135 for prostate information, and page 76 for G-spot and vaginal nerve ending information. Zappa went to the Parents Music Resource Center Senate Hearing, a former committee formed in 1985 by the wives of many Deputies with the stated goal of increasing parental control over children's access to music deemed to have violent, drug-related or sexual themes by labeling albums with Parental Advisory stickers. Zappa spoke with William Rehnquist (then Chief Justice of the United States), justices Sandra Day O'Connor, Clarence Thomas, and Al Gore, who declared himself a fan of The Mothers of Invention.
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