81 Sentences With "muscle spasm" | Random Sentence Generator

At the time I was exercising, so I knew what exercise pain felt like—like a muscle spasm.

Pitts's neck, seeking the locus of a muscle spasm, apologizing as the patient groaned with raw, guttural ache and fear.

CBD may play a role in reducing pain and muscle spasm for some conditions, but there are still a lot of unknowns.

Dr. Alexis LaPietra used a non-opioid trigger point injection to treat Fausto Arce's muscle spasm, which was so painful he couldn't turn his head.

Muscle spasm (my dinner diagnosis) is one of the most common diagnoses, but other common causes include nerve pain, skin conditions, low estrogen and endometriosis.

Anyone who has ever been woken up in the middle of the night with a sharp pain in their calf knows the agony of a muscle spasm.

" World number one Jason Day withdrew on the ninth hole with what his agent described as "a pinched joint in his lower back capsule with muscle spasm.

A heat cramp is almost exactly what it sounds like: a painful, involuntary muscle spasm that happens during intense exercise in the heat, according to the Mayo Clinic.

" If that wasn't bad enough, Garner continues that four hours in, during the Oscars telecast, "I had a panic attack in my ribs, I was having a muscle spasm.

Collman told authorities that when he picked up his son to put him in his car, he was so stiff — like "muscle spasm stiff" — that he could not move him.

"I thought, 'Oh, I must be having a muscle spasm — there's no way it could be my heart," Ravitsky, 67, an adjunct math professor at The Ohio State University at Newark, tells PEOPLE.

I recommend that any woman (or man) with pelvic floor muscle spasm skip CBD and instead see an Ob/Gyn or urologist with expertise in that area, as well as a specialized pelvic floor physical therapist.

"Just as she went to reach for the girl's hand, she stopped as if a muscle spasm had overtaken her body and, cowardly, shrank back," Ms. Naylor wrote of a neighbor trying to comfort the dead child's mother.

An oral spray with THC (tetrahydrocannabinol, which is the main psychoactive component of cannabis) and CBD is approved for use in other countries for muscle spasm caused by multiple sclerosis as well as for some kinds of chronic pain.

"They include post-surgical infection, bleeding, swelling, pain, facial bruising, jaw joint pain or muscle spasm, cracking or bruising of the corners of the mouth, restricted ability to open the mouth for several days or weeks, impact on speech, allergic reactions, tooth sensitivity to hot, cold, sweet or acidic foods, and transient, and on rare occasions permanent numbness of the jaw, lip, tongue, chin, or gums," she said.

The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.

Some patients experience muscle spasm, which led to the original term for TN of "" ("", meaning "spasm", and "", meaning "painful", in French).

Compression of a trigger point may elicit local tenderness, referred pain, or local twitch response. The local twitch response is not the same as a muscle spasm. This is because a muscle spasm refers to the entire muscle contracting whereas the local twitch response also refers to the entire muscle but only involves a small twitch, no contraction. Among physicians, various specialists might use trigger point therapy.

The devices used emit a current of three to five milliamps, sufficient to cause a localized muscle spasm but no permanent damage to any of the body's vital organs.

Thus camylofin has a comprehensive action to relieve smooth muscle spasm. It is used to treat stomach ache in infants and children. Usually it is given in combination with paracetamol to treat stomach ache, as well as pyrexia.

Cyclobenzaprine is a centrally acting muscle relaxant. Cyclobenzaprine is a 5-HT2 receptor antagonist; it relieves muscle spasm through action on the central nervous system at the brain stem, rather than targeting the peripheral nervous system or muscles themselves.

Core Topics in Pain, p. 131, Anita Holdcraft and Sian Jaggar, 2005. A constantly contracted QL, like any other muscle, will experience decreased blood flow, and, in time, adhesions in the muscle and fascia may develop, the end point of which is muscle spasm.

This can occur with a particularly strong spasm or with weakened connective tissue. A hypertonic muscle spasm is a condition of chronic, excessive muscle tone (i.e., tension in a resting muscle). This is the amount of contraction that remains when a muscle is not working.

There is increasing evidence that the smooth muscle that lines the airways becomes progressively more sensitive to changes that occur as a result of injury to the airways from dehydration. The chemical mediators that provoke the muscle spasm appear to arise from mast cells.

For patients with concurrent muscle spasm and CTTH, the muscle relaxant Tizanidine can be a helpful option. These medications however, are not effective if concurrent overuse of over the counter medications or other analgesics is occurring. Stopping overuse must occur prior to proceeding with other forms of treatment.

Heavy coating of tongue, brownish urine, metallic taste, dry mouth, and nausea occur more often. Vertigo, incoordinate ataxia, and paraesthesias have been reported on rare occasions. Tsai et al. observed psychosis which usually disappeared within a day or two after metronidazole was withdrawn, but tremors and muscle spasm lasted for several days.

Eye patching is not generally recommended as they do not help with healing or pain. Furthermore, it can result in decreased oxygen delivery, increased moisture and a higher chance of an infection. Another measure that is no longer recommended is the use of mydriatics, formerly used to relieve the pain caused by ciliary muscle spasm.

Peabody's sign is a clinical sign which may be found in patients with deep vein thrombosis (DVT). The sign is positive when calf muscle spasm occurs on raising the affected leg with the foot extended. The sign is neither sensitive nor specific for the presence of DVT. The sign was described by C.N. Peabody in 1964.

Facet joints also prevent each vertebra from slipping over the one below. A small capsule surrounds each facet joint providing a nourishing lubricant for the joint. Also, each joint has a rich supply of tiny nerve fibers that provide a painful stimulus when the joint is injured or irritated. Inflamed facets can cause a powerful muscle spasm.

Gadelha was expected to face Aisling Daly on April 11, 2015 at UFC Fight Night 64. However, Gadelha pulled out of the bout in late March citing a recent muscle spasm in her back. Subsequently, Daly was pulled from the card entirely. Gadelha next faced former WSOF Women's Strawweight Champion Jessica Aguilar on August 1, 2015 at UFC 190.

He eventually popularized its use back in England. His most famous success came when he quelled the wrenching muscle spasm of tetanus and rabies with resin. While he could not cure tetanus, he observed that the cannabis mixture reduced their symptoms of spasticity and their suffering. In 1837 he published his independent design of an electric motor.

Type of treatment can include, ice and electrical stimulation, massage, or other hand on treatment to help ease the pain and muscle spasm. After about four weeks range of motion exercises can be started. Passive exercises are done which the shoulder joint is moved but the muscles stay relaxed. After about six to eight weeks active therapy is started.

It is used to improve blood flow and subsequently healing, and to increase extensibility of tissues. Improved blood flow can also encourage fluid reabsorption, which reduces swelling, and encourages phagocytic cells to enter the site of the injury. Liniments are sometimes used to increase heat to an area. Both heat and cold have been shown to decrease muscle spasm and pain.

Trismus may be defined as inability to open the mouth due to muscle spasm, but the term is frequently used for limited movement of the jaw from any cause and usually refers to temporary limitation of movement. Trismus can occur as a result of temporomandibular joint disorder, infection, cancer therapy, complicated extraction, arthritis, complication from a mandibular block and fractures.

Duhamel/Radford received the bronze medal at the Grand Prix Final in December 2016 before winning their sixth consecutive national title. In January 2017. In February, they took the silver medal behind Sui/Han at the 2017 Four Continents Championships. At the 2017 World Championships, held in March in Helsinki, Finland, Radford had trouble training due to a muscle spasm in his hip.

The first schedule of the film was shot in Punjab with Dhawan, Bajwa and Khurana. Later, the second schedule took place in London with the rest of the team including Kapoor and Fatehi. Katrina Kaif was original choice for lead role, but she opted out, and much later, Kapoor joined the cast. During the May schedule of shooting, she suffered a muscle spasm.

The block can be functional which occurs when a severe muscle spasm of the urethra occurs to close it shut and the cat is unable to relax himself again to regain normal function. It is intensely painful and is triggered by the underlying inflammation, itself suspected to be caused by the stress of the condition. Effectively the cat involuntarily "blocks himself".

Trismus is defined as painful restriction in opening the mouth due to a muscle spasm, however it can also refer to limited mouth opening of any cause. Another definition of trismus is simply a limitation of movement. Historically and commonly, the term lock jaw was sometimes used as a synonym for both trismus and tetanus. Normal mouth-opening ranges from 35 to 45 mm.

After John Gotti became boss in December 1985, Cacciopoli became a made member in the crew led by Gotti's son, John "Junior" Gotti and brother Peter Gotti. When John Gotti went to prison in 1992 and Junior Gotti became acting boss, Cacciopoli became Junior's top protegee and bodyguard. Cacciopoli allegedly received his moniker "Tommy Twitch" because he suffered from case facial neuralgia, an uncontrollable muscle spasm condition.

Motor neuron diseases are on a spectrum in terms of upper and lower motor neuron involvement. Some have just lower or upper motor neuron findings, while others have a mix of both. Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal reflexes. Pure upper motor neuron diseases, or those with just UMN findings, include PLS.

Zeke Bratkowski relieved Bart Starr, who suffered a muscle spasm in the first half. Bratkowski directed an 80-yard drive in the fourth quarter that resulted in a go-ahead touchdown run by Elijah Pitts. John Unitas then led the Colts to the Green Bay 15, but there lost a fumble which came to be known as the 'Million Dollar Fumble', to secure the Packers' win that clinched the Western Conference crown.

Renal colic is a type of abdominal pain commonly caused by obstruction of ureter from dislodged kidney stones. The most frequent site of obstruction is the vesico-ureteric junction (VUJ), the narrowest point of the upper urinary tract. Acute obstruction and the resultant urinary stasis (disruption of urine flow) can distend the ureter (hydroureter) and cause a reflexive peristaltic smooth muscle spasm, which leads to a very intense visceral pain transmitted via the ureteric plexus.

A strong aquatic component is especially beneficial for therapy programs where limited or non- weight bearing is desirable and where normal functioning is limited by inflammation, pain, guarding, muscle spasm, and limited range of motion (ROM). Water provides a controllable environment for reeducation of weak muscles and skill development for neurological and neuromuscular impairment, acute orthopedic or neuromuscular injury, rheumatological disease, or recovery from recent surgery.Koury JM. 1996. Aquatic therapy programming: guidelines for orthopedic rehabilitation.

The indicated adult dose for muscle spasm is 25 mg to 150 mg per day, increased if necessary to a maximum of 300 mg per day, in divided doses. Tetrazepam is not generally recommended for use in children, except on the advice of a specialist. Tetrazepam is only available in one strength and formulation, 50 mg tablets. The benzodiazepine equivalent of tetrazepam is approximately 100 mg of tetrazepam = 10 mg of diazepam.

Bitolterol mesylate (Tornalate) is a short-acting β2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD. In these disorders there is a narrowing of the airways (bronchi and their ramifications) that carry air to the lungs. Muscle spasm and inflammation within the bronchi worsen this narrowing. Bitolterol relaxes the smooth muscles present continuously around the bronchi and bronchioles facilitating the flow of air through them.

British Herbal Medicine Association, Dorset (Great Britain) Linden flowers are used in herbalism for colds, cough, fever, infections, inflammation, high blood pressure, and headache (particularly migraine), and as a diuretic (increases urine production), antispasmodic (reduces smooth muscle spasm along the digestive tract), and sedative. In the traditional Austrian medicine, Tilia spp. flowers have been used internally as tea for treatment of disorders of the respiratory tract, fever, and flu. New evidence shows that the flowers may be hepatoprotective.

Although most of the drugs derived from bacteria are employed as anti- infectives, some have found use in other fields of medicine. Botulinum toxin (from Clostridium botulinum) and bleomycin (from Streptomyces verticillus) are two examples. Botulinum, the neurotoxin responsible for botulism, can be injected into specific muscles (such as those controlling the eyelid) to prevent muscle spasm. Also, the glycopeptide bleomycin is used for the treatment of several cancers including Hodgkin's lymphoma, head and neck cancer, and testicular cancer.

The word comes from the Latin word cadere ("to fall"). Related terms include cadaverous (resembling a cadaver) and cadaveric spasm (a muscle spasm causing a dead body to twitch or jerk). A cadaver graft (also called “postmortem graft”) is the grafting of tissue from a dead body onto a living human to repair a defect or disfigurement. Cadavers can be observed for their stages of decomposition, helping to determine how long a body has been dead.

For physical rehabilitation, Watsu is used by aquatic therapists to improve function and increase quality of life. Watsu has been applied for treatment of patients with orthopedic and neurologic impairment, in particular for limitations in range of motion from soft tissue restrictions, muscle spasm (hypertonicity), and pain. By improving soft tissue mobility and decreasing spasm, patients can respond better to functional activities. For severe cases, short periods of Watsu can be alternated with short periods of functional activities.

The element of an act varies by whatever tort is in question but always requires voluntariness. For example, if Dave has a muscle spasm that makes his arm fling out to his side and hit Paula, who is standing next to him, any case that Paula attempts to bring against Dave for battery will fail for lack of the requisite act (which will be discussed in the section on battery, below). The act was not voluntary.

The bean bag round consists of a small fabric "pillow" filled with #9 lead shot weighing about . It is fired from a normal 12-gauge shotgun. When fired, the bag is expelled at around ; it spreads out in flight and distributes its impact over about of the target. It is designed to deliver a blow that will cause minimum long-term trauma and no penetration but will result in a muscle spasm or other reaction to briefly render a violent suspect immobile.

The kitten will appear to go from normal to flat in the space of about 2–3 hours, and will usually then stabilise. FCKS is frequently misdiagnosed as pectus excavatum due to inadequate veterinary literature or lack of experience with the condition on the part of the clinician. FCKS is most frequently caused by collapsed lungs (and not as formerly believed, by a muscle spasm in the intercostal muscles). There are numerous causes for lung collapse, and therefore numerous causes for FCKS.

Williams won the first set easily with a double break lead. Hantuchová came back and served for the set, but Williams came back to push it to a tie-break despite Williams collapsing from an acute muscle spasm at 5–5 ensuing a medical timeout. Hantuchová then won the tie- break before rain forced play to be suspended for nearly two hours. When the players returned, Williams took the last four games from the fifth game to win the match.

On 13 December 2003 Mann and Melvyn Glintenkamp entered Wickham Laboratories and removed 695 mice being used to test botulinum toxin. He was arrested at his home and the mice were returned to the laboratory. He argued that the tests were illegal because the product was being tested for cosmetic purposes, which is banned in Britain. A court rejected Mann's defence, ruling that the tests were in compliance with UK regulations, because Botox is also used for therapeutic purposes to prevent muscle spasm.

Because of the enhancement of inhibition in the CNS, most spasmolytic agents have the side effects of sedation and drowsiness and may cause dependence with long-term use. Several of these agents also have abuse potential, and their prescription is strictly controlled. The benzodiazepines, such as diazepam, interact with the GABAA receptor in the central nervous system. While it can be used in patients with muscle spasm of almost any origin, it produces sedation in most individuals at the doses required to reduce muscle tone.

Applying pressure bandages and immobilising the patient can significantly delay the onset of symptoms and remains a critical part of the management of an Australian funnel-web spider bite. Despite the venom lacking the δ-atracotoxin or atraxin of A. robustus, the symptoms are very similar to those from a Sydney funnel- web spider bite. Common symptoms include diaphoresis, hypertension, sinus tachycardia, muscle spasm or fasciculation, nausea and vomiting, altered consciousness and local pain at the bite site. Pulmonary oedema occurs frequently and comes on early.

Kristen asks specifically about what she saw in his belly, and Marco hastily suggests that it might have just been a muscle spasm. Jaimie gets help from Sarah, and they head to the nearest house to borrow a phone to call a hospital, while Marco takes a bike to the hospital. Jaimie wonders if they are being followed, but still exits the car to knock on the door. She spots the inhabitant inside, but does not realize that the parasites have already consumed him.

After deciding to drop to the 170 pound division, Maia faced Dong Hyun Kim in a welterweight bout on 7 July 2012, at UFC 148. The bout was stopped in forty-seven seconds by referee Mario Yamasaki, after Maia took Kim down and finished him with strikes from the mounted position. UFC commentator Joe Rogan said that Kim had broken a rib, but it was later revealed that he suffered a major muscle spasm. Maia fought Rick Story on 13 October 2012, at UFC 153.

In his first fight as a welterweight, former UFC Middleweight title challenger Demian Maia faced Judo black belt Dong Hyun Kim. The bout was stopped in forty-seven seconds by referee Mario Yamasaki, after Maia took Kim down and finished him with strikes from the mounted position. UFC commentator Joe Rogan said that Kim had broken a rib, but it was later revealed that he suffered a major muscle spasm. The fourth fight featured the former Strikeforce Middleweight Champion Cung Le meeting veteran Patrick Côté at middleweight.

In an eye with iridocyclitis, (inflammation of both the iris and ciliary body), the involved pupil will be smaller than the uninvolved, due to reflex muscle spasm of the sphincter muscle of the iris. Generally, conjunctivitis does not affect the pupils. With acute angle-closure glaucoma, the pupil is generally fixed in mid-position, oval, and responds sluggishly to light, if at all. Shallow anterior chamber depth may indicate a predisposition to one form of glaucoma (narrow angle) but requires slit-lamp examination or other special techniques to determine it.

Kim lost to Demian Maia via TKO on July 7, 2012, at UFC 148. The bout was stopped in forty-seven seconds in the first round by referee Mario Yamasaki, after Maia took Kim down and ended up in the mounted position. Many observers, including the UFC commentator Joe Rogan, thought that Kim had broken a rib during the bout, but it was later revealed that he suffered a major muscle spasm while defending Maia's takedown attempts. Kim faced Paulo Thiago on November 10, 2012, at UFC on Fuel TV 6.

During assessment, the aim of PAIVM is to reproduce patient symptoms, and assess the endfeel of cervical movement, quality of resistance, behaviour of pain throughout the range of movement, and observe any muscle spasm. A posterior to anterior force of varying strength is applied by the therapist either centrally onto the spinous process, or unilaterally on either the left or right articular pillar. As a treatment technique, pain is treated by oscillations of small amplitude short of resistance, whilst stiffness is treated by larger amplitudes 50% into resistance.Darlene Hertling, Randolph M. Kessler, (2006).

She played for her country in the Fed Cup for the first time since 2003 in a tie against Belgium, and won her opening match but withdrew from her second, because of a knee injury. At the French Open, Williams lost in the quarterfinals to Henin. During her fourth round match against Hantuchová at Wimbledon, Williams collapsed from an acute muscle spasm at 5–5 in the second set. After a medical timeout and holding serve to force a tiebreak, rain forced play to be suspended for nearly two hours.

They found that using this metric they could distinguish from rest, voluntary muscular contractions, and even unsuccessful orgasm attempts. Since ancient times in Western Europe, women could be medically diagnosed with a disorder called female hysteria, the symptoms of which included faintness, nervousness, insomnia, fluid retention, heaviness in abdomen, muscle spasm, shortness of breath, irritability, loss of appetite for food or sex, and "a tendency to cause trouble". Women considered suffering from the condition would sometimes undergo "pelvic massage" — stimulation of the genitals by the doctor until the woman experienced "hysterical paroxysm" (i.e., orgasm).

Active ingredients in the linden flowers include flavonoids (which act as antioxidants), volatile oils, and mucilaginous constituents (which soothe and reduce inflammation). The plant also contains tannins that can act as an astringent. Linden flowers are used in colds, cough, fever, infections, inflammation, high blood pressure, headache (particularly migraine), as a diuretic (increases urine production), antispasmodic (reduces smooth muscle spasm along the digestive tract), and sedative. The flowers were added to baths to quell hysteria, and steeped as a tea to relieve anxiety-related indigestion, irregular heartbeat, and vomiting.

During a Watsu session, the recipient's heart and respiration rates decrease, depth of respiration increases, muscle tone decreases, and recipients report a deep state of relaxation. Robert Scaer suggested that deep relaxation of Watsu balances the autonomic nervous system (ANS), decreasing sympathetic response and increasing parasympathetic response, with far-reaching benefits. Compressive forces of hydrostatic pressure combine with deep relaxation to enhance functioning of the lymphatic system and reduce swelling in cases of edema. For orthopedic impairments, combined effects of relaxation, warm water, and gentle movement decreases muscle spasm, provides pain relief, improves soft tissue mobility, and increases range of motion.

His last televised match was on the December 9 episode of Superstars, where he defeated enhancement talent Tony Williams. His last appearance on WWF television was at In Your House 5, when he was booked to wrestle Ahmed Johnson. According to the storyline, his back was not in wrestling condition, so he introduced Buddy Landel as his substitute, who was subsequently defeated by Johnson in just forty-two seconds. His very last day working in WWF was at Madison Square Garden where he was diagnosed with a severe muscle spasm in his back that if agitated could have paralyzed him.

Sedation is very common, and extrapyramidal side effects are common and include restlessness, dystonic reactions, pseudoparkinsonism, and akathisia; the extrapyramidal symptoms can affect 2% of people at low doses, whereas higher doses may affect as many as 40% of people. Prochlorperazine can also cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include high fever, stiff muscles, neck muscle spasm, confusion, irregular pulse or blood pressure, fast heart rate (tachycardia), sweating, abnormal heart rhythms (arrhythmias). Research from the Veterans Administration and United States Food and Drug Administration show injection site reactions.

Symptoms of the female hysteria diagnosis – a concept that is no longer recognized by medical authorities as a medical disorder – included faintness, nervousness, insomnia, fluid retention, heaviness in abdomen, muscle spasm, shortness of breath, irritability, loss of appetite for food or sex, and a propensity for causing trouble. It may be that women who were considered suffering from female hysteria condition would sometimes undergo "pelvic massage" – stimulation of the genitals by the doctor until the woman experienced "hysterical paroxysm" (i.e., orgasm). In this case, paroxysm was regarded as a medical treatment, and not a sexual release.

And before admission, parents have to sign contracts in which they deliver their guardianship of kids partially to the hospital and acknowledge that their kids will receive ECT. Frequently, ECT is employed as a punishment method upon patients who breaks any of the center's rules, including "eating chocolate, locking the bathroom door, taking pills before a meal and sitting on Yang's chair without permission". It is reported in a CCTV-12 segment that a DX-IIA electroconvulsive therapy machine is utilized to correct Internet addiction. The machine was, later on, revealed to be illegal, inapplicable to minor and can cause great pain and muscle spasm to recipients.

Tourists frequent the hot springs, seeking treatment for chronic physical ailments such as skin and circulatory diseases, and bone, joint, back and muscular pains. The water in the springs contains elements with healing properties, including sodium, calcium, chloride, radon, hydrogen sulfide and carbon dioxide. The hot water treatment is also useful in cases of chronic rheumatism, muscle spasm, back pain, blood vessels, varicose veins, skin diseases, and overall body activation of nervous and psychological exhaustion, endocrine secretion and chronic sinusitis. In addition to immersing the body in the springs, as in a shower, bubble bath, jacuzzi bath or waterbed, foot baths and steam treatments are available.

RACTOPAMINE (addendum). WHO FOOD ADDITIVES SERIES: 53 The metabolic fate of ractopamine hydrochloride is similar in the target species (pigs and cattle), laboratory animals, and humans. Besides the pharmacology effect, ractopamine may cause intoxication effect; therefore, any consumption by humans of a meat and/or byproducts of animals that consumed ractopamine with feed for growth stimulation, may result in such clinical effects as tachycardia and other heart rate increases, tremor, headache, muscle spasm, or high arterial blood pressure. The effect of ractopamine on humans is not entirely known, but consumption of products that contain ractopamine residues is not advisable for persons with cardiovascular diseases.

Pirenzepine (Gastrozepin), an M1 selective antagonist, is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight- or-flight), resulting in an increase in gastric motility and digestion; whereas pirenzepine would inhibit these actions and cause decreased gastric motility leading to delayed gastric emptying and constipation. It has no effects on the brain and spinal cord as it cannot diffuse through the blood–brain barrier. Pirenzepine has been investigated for use in myopia control.

TetrazepamNL Patent 6600095 (is marketed under the following brand names, Clinoxan, Epsipam, Myolastan, Musaril, Relaxam and Spasmorelax) is a benzodiazepine derivative with anticonvulsant, anxiolytic, muscle relaxant and slightly hypnotic properties. It was formerly used mainly in Austria, France, Belgium, Germany and Spain to treat muscle spasm, anxiety disorders such as panic attacks, or more rarely to treat depression, premenstrual syndrome or agoraphobia. Tetrazepam has relatively little sedative effect at low doses while still producing useful muscle relaxation and anxiety relief. The Co- ordination Group for Mutual Recognition and Decentralised Procedures-Human (CMD(h)) endorsed the Pharmacovigilance Risk Assessment Committee (PRAC) recommendation to suspend the marketing authorisations of tetrazepam- containing medicines across the European Union (EU) in April 2013.

Teprotumumab, sold under the brand name Tepezza, is a medication used to treat adults with thyroid eye disease, a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to bulge outwards. The most common side effects are muscle spasm, nausea, hair loss, diarrhea, fatigue, high blood sugar, hearing loss, dry skin, altered sense of taste and headache. Teprotumumab should not be used if pregnant, and women of child- bearing potential should have their pregnancy status verified prior to beginning treatment and should be counseled on pregnancy prevention during treatment and for six months following the last dose. It is a human monoclonal antibody developed by Genmab and Roche.

Symptoms may include sensory changes such as numbness, tingling, paresthesia, and motor changes such as muscular weakness, paralysis, and affection of reflexes. If the herniated disc is in the lumbar region, the patient may also experience sciatica due to irritation of one of the nerve roots of the sciatic nerve. Unlike a pulsating pain or pain that comes and goes, which can be caused by muscle spasm, pain from a herniated disc is usually continuous or at least continuous in a specific position of the body. It is possible to have a herniated disc without pain or noticeable symptoms if the extruded nucleus pulposus material doesn't press on soft tissues or nerves.

A Reata-funded, Phase 2 multi-center RCT (BEAM) in patients with moderate to severe CKD and type 2 diabetes reported that eGFR was increased (> 10 ml/min/1.73 m²) in patients treated with bardoxolone methyl for 24 months. An analysis of secondary endpoints showed that approximately three-quarters of bardoxolone methyl-treated patients experienced at least a 10 percent increase in eGFR, and one-quarter of the patients had an improvement of 50%. Adverse events in bardoxolone methyl- treated patients were generally manageable and mild to moderate in severity, with muscle spasm being reported most frequently. In 2014, Reata announced the initiation of a placebo-controlled, multicenter Phase 2 study (LARIAT), to assess the effects of bardoxolone methyl in pulmonary arterial hypertension.

The photos of this incident circled the globe, with the exception of the Soviet Union and its satellites, although the event was broadcast live on TV in many countries of the Bloc. While international observers varied in their reaction to the incident, Kozakiewicz's act received much support in Polish society, which resented Soviet control over Eastern Europe (Poland was in the midst of labor strikes that led to the creation of the labor union Solidarity less than two months later). After the 1980 Olympics ended, the Soviet ambassador to Poland demanded that Kozakiewicz be stripped of his medal over his "insult to the Soviet people". The official response of the Polish government was that Kozakiewicz's arm gesture had been an involuntary muscle spasm caused by his exertion.

Middleton accepted a football scholarship from Indiana University with the plan of being the eventual successor at running back to Anthony Thompson. A chronic injury to his right ankle that he suffered in the Ohio All-Star game, forced the team to redshirt him in his first season. As a freshman, because of his size and athletic ability, the coaching staff wanted to find a way to get him on the field and converted him into a cornerback, although his body type was considered heavy for the position. As the starter at left cornerback he made 59 tackles (fourth on the team), 5 tackles for loss, 2 sacks, one interception and one pass defensed. As a sophomore, he experienced a muscle spasm in the walls of his heart and missed 2 games. He finished the season with a career-high 65 tackles, 6 tackles for loss, 4 passes defensed and one interception.

By 1982, eye muscles had been injected for strabismus and nystagmus (jerky, involuntary eye movements), eyelid muscles for retraction and blepharospasm (sustained, involuntary contractions of muscles around the eye), facial muscles for hemifacial spasm, and limb muscles for dystonia (sustained muscle spasm), all as predicted in Scott’s 1973 study. Scott also injected the first cases of the painful, spastic twisting of the neck known as torticollis, but it was difficult to accept that the spedcificity and molecular tenacity that made ingested toxin so deadly also made it safe when injected into a target muscle, and no Bay Area physician would try Botox for the muscle contractures of stroke, dystonia, torticollis, or cerebral palsy, until L. Andrew Koman of Wake Forest University in North Carolina pioneered its use to treat pediatric leg spasm in cerebral palsy. Patient groups quickly spread the word that there were now effective treatments for previously untreatable motility disorders such as blepharospasm, which can result in functional blindness despite an otherwise normal visual system. Torticollis patients discovered that their pain could be markedly reduced, motility increased, and head position improved by toxin injection.