It's one of the most therapeutic things in the world, especially the harmonizing.
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I feel like, for me, it was most therapeutic when I wrote about it.
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Going about the work of dismantling this lens, difficult as it was, was the most therapeutic thing I could have done for myself.
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It was by far one of the most therapeutic experiences of my life, since it was through writing that I was able to really understand my story, to really tell it to myself for the first time.
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Spending that much time inside one's head, along with the voices and the bats hanging from the various dendrites and neurons, is one of the best things about running, or at least one of the most therapeutic.
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At one point, during "Under the Bridge," MØ starts harmonizing with my off-tune droning during the line "And I don't ever wanna feeeel, like I did that day / take me to the place I looove, take me all the way" and I am looking at her, and she is looking at me, and I am thinking to myself that this "duet" is possibly the most therapeutic activity I have done all year.
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An insulinoma removed from a woman in Munich provided insulin mRNA that was used in the first human gene cloning experiment. In 1979, Axel Ulrich cloned this gene into E. coli. Most therapeutic insulin used today derives from this woman's tumor.
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This feature, along with the ability to infect quiescent cells present their dominance over adenoviruses as vectors for human gene therapy. Use of the virus does present some disadvantages. The cloning capacity of the vector is relatively limited and most therapeutic genes require the complete replacement of the virus's 4.8 kilobase genome. Large genes are, therefore, not suitable for use in a standard AAV vector.
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In traditional drug delivery systems such as oral ingestion or intravascular injection, the medication is distributed throughout the body through the systemic blood circulation. For most therapeutic agents, only a small portion of the medication reaches the organ to be affected, such as in chemotherapy where roughly 99% of the drugs administered do not reach the tumor site.Trafton, A. Tumors Targeted Using Tiny Gold Particles. MIT Tech Talk.
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Although bewildered, Lily plays along, acknowledging that they are playing a "prison game." As Timothy continues to move the pile of rocks, Ritchie and Lily sit and watch from the beach house porch. When Timothy starts to take a break, Ritchie orders him to stand and hold a large rock, telling Lily that Timothy is undergoing the most therapeutic experience of his life. Ritchie informs Lily that, during Revolutionary War battles, families of officers often watched from nearby.
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PP2 has been identified as a potential biological target to discover drugs to treat Parkinson's disease and Alzheimer's disease, however as of 2014 it was unclear which isoforms would be most beneficial to target, and also whether activation or inhibition would be most therapeutic. PP2 has also been identified as a tumor suppressor for blood cancers, and as of 2015 programs were underway to identify compounds that could either directly activate it, or that could inhibit other proteins that suppress its activity.
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For example, cobra venom has been found to have a bioavailability of 41.7% when injected intramuscular, and for other venoms this may even be less than 10%. These values are quite low compared to those of most therapeutic drugs, which usually have a bioavailability of nearly 100% after intramuscular injection. In general, toxic peptides of 10-40 amino acids have been found to have a relatively poor bioavailability due to their size and hydrophilicity. Thus, calciseptine, containing 60 amino acids, is expected to have a low bioavailability as well.
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Completing his report in 1918, Corti stated that the Río Hondo Hot Springs were among the most therapeutic on earth and, coming at a time when mineral springs were becoming a leading destination for health tourism, Río Hondo quickly began attracting visitors from all over Argentina. Set aside as a public resort in 1932, the first formal hotel facilities were opened in the late 1940s. President Néstor Kirchner (left) signs the order removing Mrs. Juárez from her post as Governor of Santiago del Estero while Aníbal Fernández watches.
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Pharmaceutical companies, such as Lundbeck, are currently exploring the use of transcytosis as a mechanism for transporting therapeutic drugs across the human blood–brain barrier (BBB). Exploiting the body's own transport mechanism can help to overcome the high selectivity of the BBB, which typically blocks the uptake of most therapeutic antibodies into the brain and central nervous system (CNS). The pharmaceutical company Genentech, after having synthesized a therapeutic antibody that effectively inhibited BACE1 enzymatic function, experienced problems transferring adequate, efficient levels of the antibody within the brain. BACE1 is the enzyme which processes amyloid precursor proteins into amyloid-β peptides, including the species that aggregate to form amyloid plaques associated with Alzheimer's disease.
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Finally, Zelen's design, which has been used for some RCTs, randomizes subjects before they provide informed consent, which may be ethical for RCTs of screening and selected therapies, but is likely unethical "for most therapeutic trials." Although subjects almost always provide informed consent for their participation in an RCT, studies since 1982 have documented that RCT subjects may believe that they are certain to receive treatment that is best for them personally; that is, they do not understand the difference between research and treatment. Further research is necessary to determine the prevalence of and ways to address this "therapeutic misconception". The RCT method variations may also create cultural effects that have not been well understood.
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