Yet, as history demonstrates, restriction of speech might be most deleterious to the very same people that such restrictions want to defend.
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GHB, due to its high likelihood of leading to overdose, is one of the most deleterious drugs to ever reach the party scene.
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Perhaps most deleterious to society is that tech companies don't always have to abide by the same regulations as their non-tech counterparts.
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The beer itself is a 7.5% ABV saison, brewed specifically with "water from melted Polar ice caps and cloudberries from the threatened Arctic"—that is, ingredients from the very places that have seen the most deleterious effects of climate change.
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The RLA, on the other hand, reflected some severe faults of the French army. Most deleterious was the stratification between the officers, NCOs, and enlisted ranks. The officer corps was arrogant and distant in its relationship with NCOs and enlisted men; it seldom led in the field. Responsibility for leadership thus devolved on under-educated and under- trained sergeants.
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The major hematologic pathology for BTHS patients is neutropenia, a condition characterized by a decline in total number of neutrophils in circulation with an increase in monocytes and eosinophils and no fluctuations in lymphocytes. Presentation of neutropenia varies from mild to severe, cyclical to non-cyclical, and intermittent to chronic. An absolute neutrophil count of < 500/μL, defined as severe chronic neutropenia (SCN), is the most deleterious form.
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Alfonsi’s claim that was the most deleterious to Jewish-Christian relations was that the Jews knew that Christ was the Son of God and still killed him. John Tolan says that “Alfonsi was the first Latin writer of anti-Jewish polemic to assert that the Jews were guilty of deicide .” In the tenth titulus of the Dialogi contra Iudaeos, Alfonsi declares “that Christ was crucified and killed by the Jews of their own spontaneous will.” He claimed that the Jewish leaders were a deceitful people that should not be trusted, and since he used to be a Jew whom followed Rabbinical Judaism, he was qualified to reveal their thinking process.
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The overuse of pesticides and fertilizers near watersheds can also have a deleterious effect on the common logperch by killing or altering aquatic insect life, and by increasing nitrite levels. But perhaps the most deleterious impact on the common logperch comes from the introduction of the round goby, Neogobius melanostomus, which outcompetes it. Through careful farm and land management the introduction of chemicals to watersheds could be greatly reduced. Erosion can largely be avoided by halting deforestation, and the induction of invasive species may be reduced simply by better informing the public of the detrimental effects caused by releasing non-native species into the wild.
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Brain imaging coupled with human self-administration studies with the laboratory have led to the development of a three-stage model of human neurocircuitry of addiction: Binge/Intoxication, Preoccupation/Anticipation, and Withdrawal/Negative Effect. Koob, Lloyd, and Mason reviewed the laboratory models approximating each stage of the model of human addiction.(Koob et al.) The binge- intoxication phase traditionally has been modeled by drug or alcohol self- administration; the psychological effects of addiction might be modeled by the increased motivation for self-administration observed in drug-dependent animals. Self-administration studies capably model the somatic effects of addiction, but many of the most deleterious effects related to drug addiction can be considered psychological in nature.
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In 2010, coronary artery disease, lung cancer, stroke, chronic obstructive pulmonary diseases, and traffic accidents caused the most years of life lost in the US. Low back pain, depression, musculoskeletal disorders, neck pain, and anxiety caused the most years lost to disability. The most deleterious risk factors were poor diet, tobacco smoking, obesity, high blood pressure, high blood sugar, physical inactivity, and alcohol use. Alzheimer's disease, drug abuse, kidney disease and cancer, and falls caused the most additional years of life lost over their age-adjusted 1990 per-capita rates. Between 1990 and 2010, among the 34 countries in the OECD, the US dropped from 18th to 27th in age-standardized death rate.
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The preadaptation model of de novo gene birth uses mathematical modeling to show that when sequences that are normally hidden are exposed to weak or shielded selection, the resulting pool of “cryptic” sequences (i.e. proto-genes) can be purged of “self- evidently deleterious” variants, such as those prone to lead to protein aggregation, and thus enriched in potential adaptations relative to a completely non-expressed and unpurged set of sequences. This revealing and purging of cryptic deleterious non-genic sequences is a byproduct of pervasive transcription and translation of intergenic sequences, and is expected to facilitate the birth of functional de novo protein-coding genes. This is because by eliminating the most deleterious variants, what is left is, by a process of elimination, more likely to be adaptive than expected from random sequences.
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The most resistant were alanine, valine, glycine, and aminoisobutyric acid. The results also demonstrate the protective effect of meteorite powder, which reemphasizes the importance of exogenic contribution to the inventory of prebiotic organics on early Earth. ;ADAPT Bacterial endospores of the highly UV-resistant Bacillus subtilis strain MW01 were exposed to low-Earth orbit and simulated Martian surface conditions for 559 days. It was clearly shown that solar extraterrestrial UV radiation (λ ≥110 nm) as well as the Martian UV spectrum (λ ≥200 nm) was the most deleterious factor applied; in some samples only a few spore survivors were recovered from B. subtilis MW01 spores exposed in monolayers. However, if shielded from solar irradiation, about 8% of MW01 spores survived, and 100% survived in simulated Martian conditions, compared to the laboratory controls.
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In one common damage event, adjacent thymine bases bond with each other, instead of across the "ladder". This "thymine dimer" makes a bulge, and the distorted DNA molecule does not function properly. Spore-forming bacteria are of particular concern in the context of planetary protection because their tough endospores may withstand certain sterilization procedures as well as the harsh environments of outer space or planetary surfaces. To test their hardiness on a hypothetical mission to Mars, spores of Bacillus subtilis 168 and Bacillus pumilus SAFR-032 were exposed for 1.5 years to selected parameters of space. It was clearly shown that solar extraterrestrial UV radiation (λ ≥110 nm) as well as the Martian UV spectrum (λ ≥200 nm) was the most deleterious factor applied; in some samples only a few survivors were recovered from spores exposed in monolayers.
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