Awareness is paramount because ignored debt doesn't go away — it metastasizes.
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In about 50% of ocular melanoma cases, the cancer spreads, or metastasizes, to the liver.
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I fear there are Americans — left and right — prepared to participate if political violence metastasizes.
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In about 50% of patients with ocular melanoma, the cancer metastasizes, so it's important to catch it early.
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Cobble's doctor, Bradley George, says it is "quite difficult" for kids and teens to overcome osteosarcoma – especially when it metastasizes.
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How it works: Cancer metastasizes when it successfully evades or tricks a person's immune system into allowing it to spread.
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"By far the most likely explanation is that the cancer metastasizes to the liver and carries this microbiome with it," Dr. Meyerson said.
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"As ISIL metastasizes and gains allegiances throughout Africa, what U.S. military presence is required to stop and roll back its advances on the continent?" he added.
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"As a rule, basal cell never metastasizes, unless you put a mutantagenic on it like black salve, and then it will go rogue," Bui told BuzzFeed News.
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But part of what Ethan has to learn is that his father's failings aren't his own; the more Ethan tries to parent Inkling, the more it metastasizes.
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It's so easy to call it a slight, and if that metastasizes in our political discourse, we really have lost out on an incredible opportunity to take great strides forward.
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One way would be for the U.S. to use military force to destroy North Korea's nuclear and missile facilities now — better to end the threat before it metastasizes rather than after.
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Now, for the first time, researchers have results from two independent clinical trials showing that two different drugs help these patients — giving them about two more years before their cancer metastasizes.
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At the grocery store, I leave a basket of unpaid-for items by the door as I stagger outside, gasping for air as the hand pulls back my brain and fear metastasizes.
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Bong's twisty genre hybrid about a con that metastasizes into class warfare should be a priority, but it will be easier than usual to find out if the Academy got it right.
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The line starts earlier and grows faster on weekends and during South by Southwest, the festival of music, film and technology that metastasizes here each March and runs, this year, through Sunday.
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Maybe it will be the creator of the next feat of financial engineering which metastasizes when the market is under pressure and behaves in a manner never imagined by those who turned it loose.
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Bucking the verticalization trend, Matroid was able to secure enthusiastic backing from NEA — a play that will pay off if the aforementioned community metastasizes and Matroid and its API becomes an integral part of enough corporate workflows.
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That idea must be confronted and defeated before it metastasizes any further, which is why King's comments should not be given a pass, just as Trump's use of bigotry during the 2016 presidential campaign should not be forgotten.
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Additionally, scientists and doctors working in a combined study between NCCS, the Genome Institute of Singapore, Singapore General Hospital, Duke-NUS Graduate Medical School, the National University of Singapore and the Cancer Science Institute of Singapore discovered a new genetic method of detecting colorectal cancer, the most common form of cancer among men in Singapore, before it metastasizes.
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Almost a year later, the GOP Frankenstein continues on a rampage, and the cancer metastasizes with every new Trump comment — comments so vile that even House Speaker Paul RyanPaul Davis RyanEmbattled Juul seeks allies in Washington Ex-Parkland students criticize Kellyanne Conway Latina leaders: 'It's a women's world more than anything' MORE (R-Wis.) describes them as textbook racism.
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Endometrial cancer metastasizes to the lungs 20–25% of the time, more than any other gynecologic cancer.
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A rise in p66SHC promotes stress induced apoptosis. p66SHC functionally is also involved in regulating oxidative and stress- induced apoptosis – mediating steroid action through the redox signaling pathway. P52SHC and p66SHC have been found in steroid hormone-regulated cancer and metastasizes.
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Lymphangiosarcoma may present as a purple discoloration or a tender skin nodule in the extremity, typically on the anterior surface. It progresses to an ulcer with crusting to an extensive necrotic focus involving the skin and subcutaneous tissue. It metastasizes quickly.
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1 percent of the population. Characteristics of the cancer include a tumor that rarely metastasizes and is very difficult to diagnose. As is the case with Kris Carr, it is "most often an incidental finding in young asymptomatic women."Lopes, T, et al.
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This was first discussed as the "seed and soil" theory by Stephen Paget in 1889. The propensity for a metastatic cell to spread to a particular organ is termed 'organotropism'. For example, prostate cancer usually metastasizes to the bones. In a similar manner, colon cancer has a tendency to metastasize to the liver.
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Metastasis is one of the hallmarks of cancer, distinguishing it from benign tumors. Most cancers can metastasize, although in varying degrees. Basal cell carcinoma for example rarely metastasizes. When tumor cells metastasize, the new tumor is called a secondary or metastatic tumor, and its cells are similar to those in the original or primary tumor.
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Metastasis is a process of migration of tumour cells from the primary cancer site to a distant location where the cancer cells form secondary tumors. Metastatic breast cancer represents the most devastating attribute of cancer and it is considered an advanced-stage event. Human breast cancer metastasizes to multiple distant organs such as the brain, lungs, bones and liver.
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Choriocarcinoma can occur as a primary ovarian tumor developing from a germ cell, though it is usually a gestational disease that metastasizes to the ovary. Primary ovarian choriocarcinoma has a poor prognosis and can occur without a pregnancy. They produce high levels of hCG and can cause early puberty in children or menometrorrhagia (irregular, heavy menstruation) after menarche.
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Current treatments for spinal tumours have been considered way too expensive and invasive. When cancer metastasizes it predominantly tends to settle in the spinal column. A different approach to replacing harmed vertebrae has been investigated. Polymer sponge researchers were reported to being about to present their work in March 2016 to a meeting of the American Chemical Society (ACS).
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Some findings also suggest that some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production. This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
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The hallmark of a malignant tumor is its tendency to invade and infiltrate local and adjacent structures and, eventually, spread from the site of its origin to non-adjacent regional and distant sites in the body, a process called metastasis. If unchecked, tumor growth and metastasis eventually creates a tumor burden so great that the host succumbs. Carcinoma metastasizes through both the lymph nodes and the blood.
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Cuddy's relationship with House progressed throughout most of Season 7. In Episode 15, "Bombshells", Cuddy discovers blood in her urine. After several tests, Wilson finds a mass in Cuddy's kidney and schedules a biopsy to take place later in the episode. Further "imaging shows enhancing masses across multiple lobes of Cuddy's lungs", of which Foreman points out "That's what kidney cancer looks like when it metastasizes".
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Relative five-year survival of invasive epithelial ovarian cancer by stage Ovarian cancer usually has a relatively poor prognosis. It is disproportionately deadly because it lacks any clear early detection or screening test, meaning most cases are not diagnosed until they have reached advanced stages. Ovarian cancer metastasizes early in its development, often before it has been diagnosed. High-grade tumors metastasize more readily than low-grade tumors.
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Because SCLC usually metastasizes widely very early on in the natural history of the tumor, and because nearly all cases respond dramatically to chemotherapy and/or radiotherapy, there has been little role for surgery in this disease since the 1970s. However, recent work suggests that in cases of small, asymptomatic, node-negative SCLC's ("very limited stage"), surgical excision may improve survival when used prior to chemotherapy ("adjuvant chemotherapy").
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It occurs in approximately 3-5% of cancer patients. The disease is usually terminal and if left untreated, the median survival is 4–6 weeks whereas if treated, the median survival can increase to 2–3 months. Treatment will be more effective if it is done on the primary tumor before it metastasizes to the brain or spinal cord. Patients with leukaemia achieve better results compared to patients with solid tumours who have undergone treatment.
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This invasion is called metastasis. Prostate cancer most commonly metastasizes to the bones and lymph nodes, and may invade the rectum, bladder, and lower ureters after local progression. The route of metastasis to bone is thought to be venous, as the prostatic venous plexus draining the prostate connects with the vertebral veins. The prostate is a zinc-accumulating, citrate-producing organ. Transport protein ZIP1 is responsible for the transport of zinc into prostate cells.
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Cancer cells in humans may result in the patient's death if the aggressive cancer cell grows and metastasizes. However, researchers utilize these cells to study the development of cancer cells in order to find more specific treatments. For developmental biologists, embryonal carcinoma, which is derived from teratocarcinoma, is a good object for developmental study. In 1982, McBurney and Rogers transplanted a 7.5 day mouse embryo into the testis to induce tumor growth.
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Prognosis is excellent if the appropriate method of treatment is used in early primary basal-cell cancers. Recurrent cancers are much harder to cure, with a higher recurrent rate with any methods of treatment. Although basal-cell carcinoma rarely metastasizes, it grows locally with invasion and destruction of local tissues. The cancer can impinge on vital structures like nerves and result in loss of sensation or loss of function or rarely death.
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Rotter's lymph nodes are small interpectoral lymph nodes located between the pectoralis major and pectoralis minor muscles. They receive lymphatic fluid from the muscles and the mammary gland, and deliver lymphatic fluid to the axillary lymphatic plexus. These lymph nodes are susceptible to breast cancer, as the cancer sometimes spreads (metastasizes) to the interpectoral lymph nodes. Rotter's lymph nodes are named after German surgeon Josef Rotter (1857-1924), who described them in the early 19th century.
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Current research on the treatment of brain metastases includes creating new drug molecules to effectively target the blood-brain barrier and studying the relationship between tumors and various genes. In 2015, the United States FDA approved Alecensa (alectinib) for use in patients with a specific type of non-small cell lung cancer (NSCLC; ALK-positive), a type of cancer which often metastasizes to the brain, whose condition worsened after use or were unable to take another medication, Xalkori (crizotinib).
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Serous carcinoma is a Type II endometrial tumor that makes up 5–10% of diagnosed endometrial cancer and is common in postmenopausal women with atrophied endometrium and black women. Serous endometrial carcinoma is aggressive and often invades the myometrium and metastasizes within the peritoneum (seen as omental caking) or the lymphatic system. Histologically, it appears with many atypical nuclei, papillary structures, and, in contrast to endometrioid adenocarcinomas, rounded cells instead of columnar cells. Roughly 30% of endometrial serous carcinomas also have psammoma bodies.
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The cells have often developed resistance to several lines of previous treatment and have acquired special properties that permit them to metastasize to distant sites. Metastatic breast cancer can be treated, sometimes for many years, but it cannot be cured. Distant metastases are the cause of about 90% of deaths due to breast cancer. Breast cancer can metastasize anywhere in body but primarily metastasizes to the bone, lungs, regional lymph nodes, liver and brain, with the most common site being the bone.
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This means that if breast cancer metastasizes to the lungs, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. The tumor in the lung is then called metastatic breast cancer, not lung cancer. Metastasis is a key element in cancer staging systems such as the TNM staging system, where it represents the "M". In overall stage grouping, metastasis places a cancer in Stage IV. The possibilities of curative treatment are greatly reduced, or often entirely removed when a cancer has metastasized.
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Treatment and survival is determined, to a great extent, by whether or not a cancer remains localized or spreads to other locations in the body. If the cancer metastasizes to other tissues or organs it usually dramatically increases a patient's likelihood of death. Some cancers—such as some forms of leukemia, a cancer of the blood, or malignancies in the brain—can kill without spreading at all. Once a cancer has metastasized it may still be treated with radiosurgery, chemotherapy, radiation therapy, biological therapy, hormone therapy, surgery, or a combination of these interventions ("multimodal therapy").
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If the infection metastasizes, it may spread to any other organ and could be lethal if not treated. The most common treatment for AE is to surgically remove the parasite. Since it is difficult and not always possible to remove the entire parasite, medicine such as Albendazole is utilized to keep the cyst from growing back. Guided by the Tumor-Node-Metastasis (TNM) system of liver cancer, the European Network for Concerted Surveillance of Alveolar Echinococcosis and the World Health Organization Informal Working Group on Echinococcosis, a clinical classification system has been proposed.
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It most often arises centrally in larger bronchi, and while it often metastasizes to locoregional lymph nodes (particularly the hilar nodes) early in its course, it generally disseminates outside the thorax somewhat later than other major types of lung cancer. Large tumors may undergo central necrosis, resulting in cavitation. A squamous-cell carcinoma is often preceded for years by squamous-cell metaplasia or dysplasia in the respiratory epithelium of the bronchi, which later transforms to carcinoma in situ. Large scale studies such as The Cancer Genome Atlas (TCGA) have systematically characterized recurrent somatic alterations likely driving lung squamous-cell carcinoma initiation and development.
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Melanoma metastasizes early into regional lymph nodes, so excision and analysis of so-called sentinel lymph nodes is important for treatment planning and prognosis assessment. To identify the sentinel lymph node for excision, a gamma-emitting radiotracer is injected inside the primary tumor and allowed to accumulate inside the sentinel lymph node. MSOT may provide a non-radioactive, non-invasive alternative for examination of the metastatic status of the sentinel lymph node. Initial studies have shown that MSOT can detect sentinel lymph nodes based on indocyanine green (ICG) accumulation after injection in the tumor, as well as melanoma metastasis inside the lymph nodes.
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Endometrial cancer frequently metastasizes to the ovaries and Fallopian tubes when the cancer is located in the upper part of the uterus, and the cervix when the cancer is in the lower part of the uterus. The cancer usually first spreads into the myometrium and the serosa, then into other reproductive and pelvic structures. When the lymphatic system is involved, the pelvic and para-aortic nodes are usually first to become involved, but in no specific pattern, unlike cervical cancer. More distant metastases are spread by the blood and often occur in the lungs, as well as the liver, brain, and bone.
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GCCLs are particularly notable among lung cancers for their extremely unusual tendency to metastasize to the small intestine, occasionally causing obstruction, severe bleeding, and/or intussusception. This clinical characteristic of GCCL has been seen in cases spanning over half a century in time. Within the small bowel, the jejunum seems to be a preferred site for metastasis of GCCL. GCCL also often metastasizes to bone, adrenal, brain, lung, liver, kidney, Brain metastases from GCCL are particularly likely to cause significant cerebral hemorrhages as compared to other lung cancer variants, probably due to greatly increased rates of endothelial proliferation and neovascularization, tumor tissue growth, extensive necrosis, and aggressive local infiltrative character of GCCL cells.
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The importance of a stromal microenvironment, especially “wound” or regenerating tissue, has been recognized since the late 1800s. The interplay between the tumor and its microenvironment was part of Stephen Paget's 1889 "seed and soil" theory, in which he postulated that metastases of a particular type of cancer ("the seed") often metastasizes to certain sites ("the soil") based on the similarity of the original and secondary tumor sites.The Lancet, Volume 133, Issue 3421, 23 March 1889, Pages 571-573 Its role in blunting an immune attack awaited the discovery of adaptive cellular immunity. In 1960, Klein and colleagues found that in mice, primary methylcholanthrene-induced sarcomas exhibited an antitumor immune response mediated by lymph node cells to cancer cells derived from the primary tumor.
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LCLC-RP is generally considered to be an especially aggressive malignancy that metastasizes widely early on in its clinical course. Similar to most other forms of lung carcinoma, LCLC-RP may spread ("metastasize") in three major ways — by local extension and infiltration into surrounding tissues, by lymphatic spread to regional lymph nodes, and through the bloodstream (hematogeneous metastasis) to distant organs and tissues such as the liver, brain, and skeleton. It has been reported recently that LCLC-RP can metastasize locally within the airways ("aerogeneous spread"), an uncommon mechanism of extension wherein tumor cells migrate along the lung walls and septa, but do not destroy air sacs. Previously, this type of metastatic behavior had not been seen in this particular tumor, being traditionally associated almost exclusively with the "pneumonic" form of pulmonary bronchioloalveolar carcinoma.
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