How to use malignances in a sentence? Find typical usage patterns (collocations)/phrases/context for "malignances" and check conjugation/comparative form for "malignances". Mastering all the usages of "malignances" from sentence examples published by news publications.
SIGNS BINDING LETTER OF INTENT FOR DEVELOPMENT OF NEW CAR-T TECHNOLOGIES * SAYS IMMEDIATE FOCUS WILL INVOLVE PRECLINICAL WORK IN SUPPORT OF A NEW IND APPLICATION OF A CAR-T FOR HEMATOLOGICAL MALIGNANCIES * SAYS FINALIZATION OF COLLABORATIVE BINDING LOI WITH PROMAB BIOTECHNOLOGIES TO DEVELOP CHIMERIC ANTIGEN RECEPTOR CAR-T FOR HEMATOLOGICAL MALIGNANCES AND SOLID TUMOURS * SAYS UNDER AGREEMENT,CO RETAINS EXCLUSIVE LICENSE FOR COMMERCIALIZATION OF PRODUCT CANDIDATES DEVELOPED ALONE OR IN COMBINATION WITH DOS47 Source text for Eikon: Further company coverage:
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Mutations in FLT3 have also been reported in acute lymphoblastic leukemia (ALL) and myelodysplastic syndrome (MDS). Activating mutations in PDGFRA have been detected in 5-12% of Gastrointestinal stromal tumor. Fusion of PDGFRA has been found to be responsible for hematological malignances like hypereosinophilic syndrome. The amplification of chromosome 4q12, the site of the PDGFRA gene, has been identified in 13-29% of adult gliomas and in 29% to 36% of diffuse intrinsic pontine gliomas (DIPG), a subset of high-grade gliomas (HGG) in pediatric patients.
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Altered (typically elevated) expression of NEDD9 is strongly associated with cancer. NEDD9 is rarely if ever mutated, but frequently show altered expression or phosphorylation (associated with increased activity) in pathological conditions including immune cell dysfunction and cancer. NEDD9 overexpression is documented to occur and in some cases linked the process of tumorigenesis of many different malignances. Besides examples in breast cancer discussed above, these malignancies include colon, pancreatic, head and neck, ovarian, gastric, lung, genitourinary (including prostate), liver, and kidney cancer, gastrointestinal stromal tumors, glioblastoma, and neuroblastoma.
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PCM1-JAK2 gene positive patients present with features of myeloid neoplasms, lymphoid neoplasms, or features of both types of neoplasms. Most commonly, the present with features of myeloid neoplasms with 50–70% of cases associated with eosinophilia and/or bone marrow fibrosis Their disease usually progresses rapidly from a chronic phase to an acute blast cell phase resembling chronic myelogenous leukemia's conversion form chronic to acute phases. Rarely, the acute phase of PCM1-JAK2 gene positive disease resembles a lymoblastic leukemia. PCM1-JAK2-induced hematological malignances are rare and relatively newly discovered.
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