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Jack Lippes helped begin the increase of IUD use in the United States in the late 1950s. In this time, thermoplastics, which can bend for insertion and retain their original shape, became the material used for first-generation IUDs. Lippes also devised the addition of the monofilament nylon string, which facilitates IUD removal. His trapezoid shape Lippes Loop IUD became one of the most popular first-generation IUDs.
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Inert IUDs do not have a bioactive component. They are made of inert materials like stainless steel (such as the stainless steel ring (SSR), a flexible ring of steel coils that can deform to be inserted through the cervix) or plastic (such as the Lippes Loop, which can be inserted through the cervix in a cannula and takes a trapezoidal shape within the uterus). They are less effective than copper or hormonal IUDs, with a side effect profile similar to copper IUDs. Their primary mechanism of action is inducing a local foreign body reaction, which makes the uterine environment hostile both to sperm and to implantation of an embryo.
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In the 1940s, Ortho introduced the coil-spring diaphragm, and assisted in the development of the Papanicolaou smear stain to screen for cervical cancer. In 1963, Ortho introduced the second oral contraceptive available in the United States (Ortho-Novum 10 and Ortho-Novum 2, produced by Syntex). In 1964, Ortho bought rights to and marketed the Gynekoil (Margulies Coil) and Lippes Loop inert plastic IUDs in the United States until the mid-1970s and 1985, respectively. In 1968, Ortho introduced RhoGAM Rho(D) immune globulin, the first medication developed to prevent Rh hemolytic disease of the newborn. In 1973, Ortho and Syntex introduced the first progestogen only pills (mini-pills) available in the United States, Mirconor and Nor-QD. In 1982, Ortho introduced the first biphasic oral contraceptive available in the United States, Ortho-Novum 10/11.
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