1 Sentences With "inducing deafness"

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Previous research has suggested that the length of the critical period may be linked to differential gene expression within song nuclei, thought to be caused by neurotransmitter binding of receptors during neural activation. One key area is the LMAN song nucleus, part of the specialized cortical-basal-ganglia-thalamo-cortical loop in the anterior forebrain pathway, which is essential for vocal plasticity. While inducing deafness in songbirds usually disrupts the sensory phase of learning and leads to production of highly abnormal song structures, lesioning of LMAN in zebra finches prevents this song deterioration, leading to the earlier development of stable song. One of the neurotransmitter receptors shown to affect LMAN is the N- methyl-D-aspartate glutamate receptor (NMDAR), which is required for learning and activity-dependent gene regulation in the post-synaptic neuron.