171 Sentences With "have the desired effect"

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But China's campaign may not have the desired effect in Taiwan.
But the gun orders may not immediately have the desired effect.
So a ratcheting up of sanctions is unlikely to have the desired effect.
The combined base-editing tools have the desired effect more than half the time.
The treatment failed to have the desired effect as he and Duhamel finished seventh.
Now they're going to get one — even if it won't have the desired effect.
If it doesn't have the desired effect or is the wrong color, then try another.
Judging by the expression on O'Kelly's face, my attempts did not have the desired effect.
An amount of the drug that was once satisfying starts to not have the desired effect.
But a lobster expert we spoke to wasn't convinced this strategy would have the desired effect.
But it may take time for podcasts to have the desired effect on Spotify's bottom line.
He added that the tariffs would have to be "fairly broad" to have the desired effect.
Now we can disagree with some of the tactics and whether they'll have the desired effect.
"I do think a dialogue, especially an open dialogue will have the desired effect," he said.
But would changing the law in countries that don't have opt-out systems have the desired effect?
Morgan Stanley warned that a cut by the Middle East-dominated group might not have the desired effect.
And, if Snapchat's history is any indication, there's a good chance all this will have the desired effect.
Neither of these thoughts will have the desired effect on combating radical ideologies and keeping our nation safer.
A payroll tax cut might not have the desired effect of inspiring consumers to spend more, Gleckman said.
And, most critically of all, will breaking up these tech behemoths have the desired effect on protecting individual privacy?
Mr. Gianaris said Amazon's fliers, some of which urged residents to call him, did not have the desired effect.
But the photo — a woman literally standing up to a roomful of men — didn't quite have the desired effect.
It is too early to tell whether Canada's change, at the end of last year, will have the desired effect.
The evidence suggests that these stickers and agreements have the desired effect of making consumers afraid to open their electronics.
The story didn't quite have the desired effect – it didn't scare me, but I did start talking to my snot.
The longer the round wore on, Barberena's combinations and kicks to the body of Alves started to have the desired effect.
"We believe that this (the statement) will have the desired effect of calming nerves and expect a positive reaction today," they said.
But housing researchers and advocates say the proposal would not have the desired effect and would instead lead to higher rates of homelessness.
What remains worth noting, however, is that even if they don't superficially have the desired effect, these perceived slights did irk the Egyptian regime.
These moves will be resisted by Republican politicians and centrist pundits alike, but they will have the desired effect of changing the political landscape.
READ: A gun shot and water cannons: Hong Kong protests are getting scary But the arrests are unlikely to have the desired effect, activists say.
Michael Hewson, chief market analyst at CMC Markets, said the move would help Japanese banks but might not have the desired effect on the Japanese economy.
But it's unclear if cutting funding will have the desired effect, and experts don't believe that the US-brokered Middle East peace plan has a high chance of succeeding.
But for those threats to have the desired effect, Mattis and Tillerson believe the US must continue to "amp up" its military strength as a viable option, Narang said.
Of course, just because the economics make sense doesn't necessarily mean that it will be a successful business model or have the desired effect of bringing additional people online.
There's also a danger the Chinese government's stimulus measures will fail to have the desired effect, according to Louis Kuijs, head of Asia economics at research firm Oxford Economics.
One reason why it might not have the desired effect: early voting here meant that, by the time Warren took the stage, about 75,000 people had already made their picks.
"The major issue here is the delivery of the vaccine," said Gupta, who noted that current vaccines often require multiple injections throughout the year in order to have the desired effect.
When that tweet failed to have the desired effect, Trump then had Homeland Security and Counterterrorism advisor Rear Admiral Peter J. Brown release a statement attempting to bolster the president's claims.
Stocks may also be drawing support from signs that the lockdown across much of Europe could be starting to have the desired effect of slowing the rate of new confirmed cases.
They are indiscriminate, tend to damage disproportionately the most vulnerable and often the most innocent elements of society, and they seldom have the desired effect unless followed up with a military invasion.
Also probably less welcome was President Trump's threat, also made on Friday, to move on to "plan B," meaning a military attack on North Korea if sanctions don't have the desired effect.
But it looks like, for the time being, Google is taking a measured approach here and could be willing to change that approach if it turns out not to have the desired effect.
Health and Human Services Secretary Alex Azar has hinted that Trump may use his bully pulpit to publicly shame companies that raise prices, but experts are skeptical it will have the desired effect.
Maybe it's also because impeachment didn't have the desired effect for which Democrats had hoped; that, instead of hurting the president, it's hurting the party that impeached him, and did so along partisan lines.
A day after Arora's deadline passed, he and his team conducted a raid in an affluent area of cafes and coffee shops in New Delhi that showed his letters did not have the desired effect.
The approach did not have the desired effect and a week later the airline was forced to cancel another 18,000 flights and cut its growth plans, grounding 25 planes in the winter and 10 next summer.
All of these lawless activities and the media headlines they generate have the desired effect of distracting attention from the vital importance of this project for our states, region, and country and the progress it represents.
Passing a federal red flag law could save lives if these incentives have the desired effect, especially in red states where gun deaths tend to be higher as a percentage of the population than in blue states.
They were seeing higher rates than they had in the pre-ACA markets, and many experts believe the law's individual mandate, which was supposed to compel everybody to sign up, was too weak to have the desired effect.
If we're concerned with protecting the United States from these miscreants, let's do it at home, where the many billions of dollars are more likely to supply the intelligence and other resources that would have the desired effect.
That appeared to have the desired effect for the second-seeded Serb as he raised his game up a notch to convert his fourth breakpoint chance with a forehand winner at the net to grab the second set.
Trading started on a buoyant note on Monday on positive global cues, but a 2550 bps rate cut by the RBI on Tuesday did not have the desired effect on markets and investors sold into the previous day's gains.
They were seeing higher rates than they had in the pre-ACA markets, and many experts believe the law's the individual mandate, which was supposed to compel everybody to sign up, was too weak to have the desired effect.
Zooey's speech to Deja seemed to resonate, but it ultimately didn't have the desired effect, as Randall's windshield can attest to, when she takes Jack's baseball bat to it after Toby's mom told her that she looked just like her father.
The reality is somewhat different, and for OPEC's extended cuts to have the desired effect of rebalancing the crude market and keeping prices at least above $26 a barrel, other factors beyond their control will have to work in their favor.
The reality is somewhat different, and for OPEC's extended cuts to have the desired effect of rebalancing the crude market and keeping prices at least above $26 a barrel, other factors beyond their control will have to work in their favour.
It's also an indicator that international sanctions would likely have be far harsher to have the desired effect of convincing North Korean leader Kim Jong Un that it's not worth it for him to continue to pursue a nuclear weapons program.
Sky, which is 39 percent owned by Rupert Murdoch's 21st Century Fox, declined to comment on Tuesday, but it has previously said that it would like to continue to broadcast the Bundesliga.. The antitrust authority's involvement may not have the desired effect, however.
VIENNA (Reuters) - The European Central Bank's current policy aimed at spurring inflation should have the desired effect in the second half of the year, ECB Governing Council member Ewald Nowotny said on Thursday, but it is not possible to say exactly when.
But these days, most experts largely believe that the tax penalty for not having insurance was actually too low to have the desired effect, even as Trump cites its "tremendous" nature and that the law's markets will survive — if imperfectly — without it.
Commerce Secretary Wilbur Ross, a leading protectionist voice in the Trump administration, said Friday on CNBC that Trump appeared to be suggesting that certain allies would be exempted, adding that tariffs would have to be "fairly broad" to have the desired effect.
It's obviously true that people bear responsibility for their actions – but it's also true that sticking to a strategy that relies mostly on just telling people to be more mindful when that's failing to have the desired effect is not only stupid, but also dangerous.
Rubio is framing his proposal as a necessary step for the United States to compete with China, in his view the country's greatest geopolitical threat, but implicit in its design is a recognition the GOP bill didn't have the desired effect on business behavior.
The tougher rules will have the desired effect for the party, winnowing the field and giving a bigger spotlight to top-tier contenders former Vice President Joe Biden, and U.S. Senators Elizabeth Warren of Massachusetts, Bernie Sanders of Vermont and Kamala Harris of California.
Some experts say that such a benchmark — known as the symptomatic case fatality rate — could be lower in countries like the United States if measures like widespread business and school closures and appeals for social distancing have the desired effect of slowing the spread of the disease.
Some experts say that such a benchmark — known as the symptomatic case fatality rate — could be lower in countries like the United States if measures like widespread business and school closures and appeals for social distancing have the desired effect of slowing the spread of the disease.
Like the e-sports Super Bowl, TI is the grandest tournament that every player wants to be a part of, so if Valve's changes have the desired effect, we'll see a fairer, more predictable system, which should also make for more competitive and watchable matches along the way.
" It appears he intended to detonate the device when he did, Cuomo said Monday, but added that although an "explosive chemical" in the bomb went off, it "did not have the desired effect of causing the pipe itself to shatter, which would have caused the more significant damage.
While the use of police cameras is associated with a reduction in police violence in some jurisdictions, it is not clear whether introducing body cameras nationwide will have the desired effect: perhaps police departments that chose to participate in a study have more positive attitudes towards body cameras than those who do not.
I know you're the coach and I'm still pretending to be this hypothetical self-absorbed teenager, but this is a pretty dickish way to talk to people and I can almost guarantee that not only will it not have the desired effect, it will produce the exact opposite result you were looking for.
"Incremental rate cuts may not have the desired effect as public sector banks (which constitute 70 percent of the banking system) may remain reluctant to cut lending rates or approve new loans in the backdrop of stressed balance sheets and weak corporate sector performance," Taimur Baig, chief economist at Deutsche Bank, said in a note last week.
The main price factor for Brent is whether a decision led by the Organization of the Petroleum Exporting Countries (OPEC) to extend a pledge to cut production by around 1.8 million barrels per day (bpd) until the end of the first quarter of 2018 will have the desired effect of significantly tightening the market to end years of oversupply.
This atropinization can take up to 12 hours and must be repeated in order to have the desired effect.
The bombardment, however, did not have the desired effect as much of the German barbwire and machine gun nests were left intact. Despite this, the Ulster Division advanced with remarkable speed, crashing in force into the German 4th line.
In 1973, provision was made for the creation of liaison and coordinating committees, and a restricted right to strike was accorded black workers. This attempt to accommodate black interests, without recognizing their parity with white interests, did not have the desired effect.
A.M. Strinnholm, Svenska folkets historia, Vol. IV. Stockholm; Hörbergska Boktryckeriet, 1852, p. 236. Pope Innocent III, impressed by Sverker's pro-papal policy, ordered Eric to settle the conflict with Sverker, or else take serious consequences. However, his admonitions did not have the desired effect.
Arsaces approached Justin and attempted to convince him about the reasons to eliminate Emperor Justinian. He discussed how the Byzantine emperor "ill-treated and passed over his relatives". He also pointed Belisarius as a threat to them. This did not have the desired effect.
The reason for his recall is unknown, and his placement at St. Rose did not have the desired effect. He was expelled from the community in 1840 for unspecified reasons. His superior, the Rev. Nicholas Young, OP, does refer to his being "crazy" at times.
Because seashells are in some areas a readily available bulk source of calcium carbonate, shells such as oyster shells are sometimes used as soil conditioners in horticulture. The shells are broken or ground into small pieces in order to have the desired effect of raising the pH and increasing the calcium content in the soil.
As seen, the union did not have the desired effect. Therefore, to resume hostilities with the participation of two of the sons of Murad I, Yakub Çelebi and Bayezid, therefore, brethren Nefise. Defeated, Alaeddin took refuge in Konya. To get out of this mess, he sent Nefise to her father, to ask for forgiveness from the Sultan.
The constructions did not have the desired effect of stopping the erosion caused by crossways currents. "Leeward erosion", i.e. erosion on the downwind side of the groynes prevented sustainable accumulation of sand. In the 1960s breaking the power of the sea was attempted by installing tetrapods along the groyne bases or by putting them into the sea like groynes.
She starts changing the bed around him and he tells her she has control issues. She leaves him the bed and goes to sleep on the couch. While flipping channels she comes across a horror film about rats and has a brainstorm. The next day she lets loose a rat in the house and waits for it to have the desired effect.
A trial found Doughty guilty, but only on the mutiny charge. At Drake's insistence, Doughty was beheaded, but this stern example did not have the desired effect. Increasing tensions between mariners and gentlemen explorers brought the prospect of mutiny about a month later. Drake used a sermon to make a speech laying down rules of conduct, with himself in sole command.
Afterwards, these compounds are tested in animals to see if they have the desired effect. This approach is known as "reverse pharmacology" or "target based drug discovery" (TDD). However recent statistically analysis reveals that a disproportionate number of first-in-class drugs with novel mechanisms of action come from phenotypic screening which has led to a resurgence of interest in this method.
However, if it is important enough to report, how quickly should it be reported? If the information is time sensitive but it is not disseminated in enough time to have the desired effect then the process fails. Compartmentalization, either in isolation of planners from flow of intelligence or invocation of need to know among analysts, strongly contributes to failures in dissemination.
He took a heavy-handed approach to asserting his authority and deported several leaders of the Mau. This did not have the desired effect and dissent amongst the general population towards the New Zealand administration only increased. Richardson was forced to call in marines from the New Zealand Division of the Royal Navy to deal with the civil unrest. Shortly afterwards, on 31 March 1928, he retired.
Angie unwittingly starts a bar fight (with a little help from John) and is hauled off to jail. The next morning, Mr. Biddle comes to bail Angie out. He tells Angie he has to forget about his own dreams and accept his place in the family business. His words have the desired effect, inspiring Angie to defy his mother and elope with Cordy and go to Detroit.
In case of refusal, Eric would be censured by the Church. This did not have the desired effect, and in 1210 Sverker invaded Sweden in an attempt to reconquer the throne. However, he was defeated in the Battle of Gestilren in July 1210. This time Sverker was killed at the hands of Folke Jarl and his party; however, Folke was also slain together with many Folkungs.
In order to have the desired effect, the question must imply something uncommon enough not to be asked without some evidence to the fact. For example, the question "Does Mr. Jones have a brother?" would not cause the listener to think there must be some evidence that he does, since this form of general question is frequently asked with no foreknowledge of the answer.
"Try" earned critical acclaim from music critics. Jason Lipshut of Billboard called it an "empowering" track [...] to bestow young girls with a stronger sense of self- worth." Emileen Lindner of MTV News agreed, calling it "a super-empowering ballad." Holly Williams of Contact Music called it "a bright pop song with an admittedly overly simple melody, but the lyrics, though hackneyed and a little patronising, still have the desired effect.
In 1867, after critical complaints, Lawson recalled the parliament, and proposed the removal and sale of the steam cultivator. This motion infuriated the membership, as they argued that the plough epitomised their role as ‘Model Farmers’. However, at the following meeting a packed audience voted overwhelmingly to overthrow this proposal. This threat appeared to have the desired effect and swiftly transformed an annual loss of £343 into a profit of £260.
Against normal convention, a bullet through the brain does not have the desired effect, and neither does hanging himself with Christmas lights. He even throws himself in front of the subway train, but only succeeds in severing his arm. Bart then boards a train, where he finds and reads a letter that Janet left in his uniform's pocket at his funeral. He breaks down and attacks the only other passenger.
Taxable, Glimmer and Big Drum were complicated in execution, requiring coordination of air and naval forces. Launched in poor weather conditions, Taxable did not appear to have the desired effect and failed to elicit any significant response from the Germans. The reaction to Glimmer was more encouraging. The attacks on the bomber squadrons indicated, at least to the satisfaction of RAF Bomber Command, that the Germans believed a genuine threat existed.
However, the raids did not have the desired effect; these countries kept supplying soldiers for the crusades against the Hussites. During a war between Poland and the Teutonic Order, some Hussite troops helped the Poles. In 1433, a Hussite army of 7,000 men marched through Neumark into Prussia and captured Dirschau on the Vistula River. They eventually reached the mouth of the Vistula where it enters the Baltic Sea near Danzig.
Van Lom fled Amsterdam after the arrests in January 1945, and returned in March. After a meeting with a resistance member he was abducted and interrogated, and sentenced to die by poisoning. Either he refused to drink the poison or it did not have the desired effect and he was finally despatched with a shot to the neck, his body dumped in the Keizersgracht. He was 26 years old.
The Danish Medicines Agency (Lægemiddelstyrelsen) is an agency under the Danish Ministry of Health and Prevention. The purpose of the agency is to ensure that medicinal products used in Denmark are of satisfactory quality, are safe to use and that they have the desired effect. It supervises companies manufacturing and distributing medicinal products. This is done through administering the Danish legislation on medicinal products, reimbursement, pharmacies, medical devices and euphoriants.
When the incessant attacks of skirmishers failed to have the desired effect, the weight of the attack was switched to the rear of the Crusader column, with the Hospitallers coming under the greatest pressure.Verbruggen, p. 237. Here the right wing of the Ayyubid army made a desperate attack on the squadron of Hospitaller knights and the infantry corps covering them. The Hospitallers could be attacked from both their rear and flank.
Wiltord then collected the ball from midfield and played a one-two with Henry, but directed his shot wide from the left flank. Chelsea made their second change in the 67th minute, bringing on Zola for Hasselbaink. The substitution did not have the desired effect as Arsenal went a goal ahead. Adams cleared the Chelsea danger and Wiltord's reverse pass found Parlour with acres of space to manoeuvre.
Sima Yong became regent. Sima Yong tried to appease possible opposing forces by promoting all of the major princes and warlords, but his promotions did not have the desired effect. In fall 305, Sima Yue declared yet another rebellion, this time against Sima Yong, claiming that Sima Yong had improperly forced Emperor Hui to move the capital. Various provincial governors and military commanders were forced to be on one side or the other.
The first phase of the war began with the Soviet intervention in Afghanistan and first battles with various opposition groups. Soviet troops entered Afghanistan along two ground routes and one air corridor, quickly taking control of the major urban centers, military bases and strategic installations. However, the presence of Soviet troops did not have the desired effect of pacifying the country. On the contrary, it exacerbated nationalistic sentiment, causing the rebellion to spread further.
In June 1985, the first case of AIDS was reported in China. At first, the disease was largely considered a disease of foreigners since most of the people diagnosed from 1985 to 1988 were either foreigners or Chinese people who had recently been overseas. The Chinese government took quick action by immediately banning all import of blood products. However, this action did not have the desired effect since AIDS continued to spread throughout China.
With the crew of the Doric Star transferred to the Graf Spee the boarding party proceeded to sink the Doric Star, however this proved to be more difficult than initially envisaged. Scuttling charges were placed within the ship however they failed to have the desired effect. Following this Graf Spee opened fire using some of her secondary armament of SK C/28 guns discharging 7 rounds which, with the aid of a torpedo, finally sank the Doric Star.
The intruders set about building an oppidum (hillfort) near the site of the future Roman colony of Aquileia (NE Italy), in the territory of the Veneti, who were Roman allies. The Romans, who by this time considered Cisalpine Gaul their own sphere of influence, immediately despatched envoys to protest. When this diplomacy did not have the desired effect, the Romans despatched two armies to the region. The Norici backed down, surrendering to the Romans without a fight.
Morrill, p. 60 When the bombardment failed to have the desired effect, d'Estaing changed his mind, and decided it was time to try an assault. He was motivated in part by the desire to finish the operation quickly, as scurvy and dysentery were becoming problems on his ships, and some of his supplies were running low. While a traditional siege operation would likely have succeeded eventually, it would have taken longer than d'Estaing was prepared to stay.
William Trent, the trader turned militia commander who had come up with the plan, sent a bill to the British Army indicating that the purpose of giving the blankets was "to Convey the Smallpox to the Indians." The invoice's approval confirms that the British command endorsed Trent's actions. Reporting on parleys with Delaware chiefs on 24 June, Trent wrote: '[We] gave them two Blankets and an Handkerchief out of the Small Pox Hospital. I hope it will have the desired effect.
314–315 Al-Mansur sent his son and heir, al-Mahdi (r. 775–785), to recover the treasure of Abu Muslim. Khurshid denied having it, and al-Mansur tried to unseat Khurshid by crowning one of his cousins as ispahbadh. This did not have the desired effect of challenging the loyalty of Khurshid's subjects, but Khurshid was eventually forced to accommodate the Abbasids by accepting an increase in the annual tribute, which brought it to the level paid to the Sassanids.
Economic development did not bring prosperity to all. During the 1960s many of the rural poor felt increasingly dissatisfied with their condition in society and disillusioned by their treatment by the central government in Bangkok. Efforts by the Thai government to develop poor rural regions often did not have the desired effect in that they contributed to the farmers' awareness of how bad off they really were. It was not always the poorest of the poor who joined the anti-government insurgency.
Farrar, Straus and Giroux, p. 29 He also formulated a general defence for religious toleration in his Letters Concerning Toleration. Three arguments are central: (1) earthly judges, the state in particular, and human beings generally, cannot dependably evaluate the truth-claims of competing religious standpoints; (2) even if they could, enforcing a single "true religion" would not have the desired effect because belief cannot be compelled by violence; (3) coercing religious uniformity would lead to more social disorder than allowing diversity.McGrath, Alister. 1998.
Economic development did not bring prosperity to all. During the 1960s many of the rural poor felt increasingly dissatisfied with their condition in society and disillusioned by their treatment by the central government in Bangkok. Efforts by the Thai government to develop poor rural regions often did not have the desired effect in that they contributed to the farmers' awareness of how bad off they really were. It was not always the poorest of the poor who joined the anti-government insurgency.
The White House also suggested that reporters take short trips to Saigon instead of long trips where they could develop their own sources and not rely on government sources for information. Citing the need for secrecy, some things must be kept secret to protect vital information that could benefit enemies. However, this suggestion did not have the desired effect, putting more of a spotlight on the issue. The U.S. were accused by reporters in Vietnam of trying to fight too many battles at one time.
Short was in Fort Worth when a Kansas newspaper reported that he was "lying at death's door."Wichita Daily Eagle August 4, 1893 Short and a number of friends, and with Hattie beside him, took the north-bound Santa Fe train for Geuda Springs, Kansas. The place offered a change of climate as well as the medicinal qualities of the famous waters, which, it was hoped, would "prolong his life."Fort Worth Gazette August 23, 1893 The move did not have the desired effect.
The Sons had won the previous encounter at Falkirk and following the forwards display the previous week changes were made with Robertson and Duncan coming in at inside and outside left respectively. In addition Crichton replaced Oldcorn in goal. As it was the changes failed to have the desired effect and in a disappointing display the visitors departed with both points in a 2-0 win. A week later, Dumbarton took a rest from competitive matches to play neighbours Renton in a friendly at Boghead.
The onions have the desired effect, but they also make his breath so pungent that it causes the entire audience to cry. Next the constable tries to frame Fatty by insinuating it was he who stole the money from the insured letter. As Fatty tries to deny the charges to his friends, they all (including his dog (Luke) turn their backs on him in disgust. Fatty believes their reaction is due to their not believing him, but it is actually due to his repugnant onion breath.
By penalising the distribution of profits, it was hoped companies would retain profits for investment, which was considered a priority after the Second World War. The tax did not have the desired effect, so the distributed profits tax was increased by 20% "50 years ago ", Newark Advertiser. Retrieved 8 March 2015 by the post-war Labour government to encourage companies to retain more of their profits. At the time of Hugh Gaitskell's 1951 budget, the profits tax was 50% for distributed profits and 10% for undistributed profits.
The first instance of large-scale use of gas as a weapon was on 31 January 1915, when Germany fired 18,000 artillery shells containing liquid xylyl bromide tear gas on Russian positions on the Rawka River, west of Warsaw during the Battle of Bolimov. Instead of vaporizing, the chemical froze and failed to have the desired effect. The first killing agent was chlorine, used by the German military. Chlorine is a powerful irritant that can inflict damage to the eyes, nose, throat and lungs.
The Gladiators relocated to Las Vegas, Nevada, for the 2003 season and played their home games at the Thomas & Mack Center on the campus of the University of Nevada, Las Vegas. This arena was also the home of a previous Arena team, the Las Vegas Sting, in 1994 and 1995. In 2007, in an effort to increase attendance, the Gladiators moved to the Orleans Arena. The move did not have the desired effect; the Gladiators averaged 5,383 fans in 2007, down from 10,115 in 2006.
A return to a full strength squad did not have the desired effect on 19 November as Dumbarton lost away to Leith Athletic by 3-0. Notwithstanding the score, Dumbarton had most of the play but were met by a ‘superlative’ display by the Leith goalkeeper. The 26 November saw Dumbarton visit Clyde for their first game in the Scottish Cup. Unfortunately the weather had turned Barrowfield Park into a ‘series of small lakes’, nevertheless a friendly was played which Clyde won 4-1.
More recently it has become popular to develop a hypothesis that a certain biological target is disease modifying, and then screen for compounds that modulate the activity of this purified target. Afterwards, these compounds are tested in animals to see if they have the desired effect. This approach is known as "reverse pharmacology" or "target based drug discovery" (TDD). However recent statistical analysis reveals that a disproportionate number of first-in-class drugs with novel mechanisms of action come from phenotypic screening which has led to a resurgence of interest in this method.
Commander William Trent wrote that he hoped "it will have the desired effect." Colonel Henry Bouquet, leading a relief force, would discuss similar tactics with Commander-in-Chief Jeffery Amherst. The effectiveness of these attempts to spread the disease are unknown, although it is known that the method used is inefficient compared to respiratory transmission, and it is difficult to differentiate from naturally occurring epidemics resulting from previous contacts with colonists. During and after Pontiac's War, epidemics of smallpox among Native Americans devastated the tribes of Ohio Valley and the Great Lakes areas.
This did not have the desired effect, however, of satisfying royal desires for influence in the south and Rudolph accompanied Ebalus of Aquitaine against the Vikings a short while later, strengthening the Ramnulfid dynasty against that of the Rouergue in the fight for supremacy in Aquitaine.Lewis, 187. Ermengol and his wife Adelais (Adalaiz) had two known sons and one daughter, though charters of his eldest son indicate that he had other sons besides his two heirs. The eldest son was Raymond, who inherited Rouergue, and the second was Hugh, who received Quercy.
William Elcoat succeeded Mitchell as manager in April 1898, and set about reviving the squad with new additions. The changes did not have the desired effect; his team finished seventh in a league of 18 and were beaten 6–0 by Derby County in the FA Cup first round. He departed in February 1899, and like his predecessor only remained for a season. Harry Bradshaw, appointed in the summer of 1899, was faced with several difficulties, not least falling attendances and limited funds to attract the best players.
At the Wairarapa end of the workings, the approach cutting to the tunnel had been completed and about 40 feet of the tunnel driven. In December 1874, on learning of the slow progress the contractors were making on the tunnel, the Government made the first of many complaints, which seemed to have the desired effect. The Evening Post, a critic of the railway, reported in the following March that work was proceeding rapidly and satisfactorily. The following June, work on the tunnel was proceeding at about a chain a month, little faster than before.
The changes however did not have the desired effect as the Sons slumped to their fourth consecutive defeat by tamely losing 0-3. Cowdenbeath were the opponents at Boghead in the league on 21 November. The defence reverted to that which started the season with Blair returning at keeper. In addition Ewart Kinnon (Mossfield Amateurs) was tried out at inside right. On a poor pitch the players struggled to show any skill but Dumbarton’s defence was much improved while only bad luck stopped the Dumbarton front line scoring – the game ending 0-0.
The half life of endogenous insulin once it enters the bloodstream is 4 to 6 minutes. This allows the endocrine system to rapidly adapt to changing conditions within the body. Exogenous insulin, however, would not be effective with a short half life, as it would require continuous injection or infusion to have the desired effect. While it is difficult to change the rate at which the protein is metabolized in the bloodstream, it is possible to alter how fast the protein is absorbed from the site of injection in various ways.
Teacher Rebecca Shelley and poet Angela Morgan became convinced that Ford and Schwimmer should meet. They arranged a series of demonstrations and public meetings in Detroit hoping that publicity would facilitate a meeting. When it did not have the desired effect, Shelley met with the editor of the Detroit Journal and a reporter, Ralph Yonker, who was a favorite of Ford, set up an interview for Schwimmer. Within three weeks, in early December, she set sail aboard a Peace Ship to Stockholm, chartered by Ford, with him and other pacifists.
Unfortunately, the living standards of the Kanaq people are still very low, and the help they receive often does not have the desired effect. This is confirmed by the results of a survey conducted in 2012 between the two communities of Orang Asli in the state of Johor, namely, the Kanaq and Orang Kuala. Characteristically, Kanaq people by absolutely all indicators are considerably inferior to the Orang Kuala. The reason for this, according to specialists, is due to the lack of an appropriate interest among the Kanaq people themselves.
His deportation did not end the strike, which dragged on for six months. After his deportation to India, he made an appearance at the depot in Calcutta where ex-indentured labourers had gathered to ask for return to Fiji. He asked them not to return, undertook a hunger strike and publicly cursed C.F. Andrews, whom he accused of being a recruiter. This seemed to have the desired effect as Andrews was able to bring political pressure on the Indian Government to stop further labour ships departing for Fiji.
The Prussian army could no longer be stronger than 42,000 men. The Krumpersystem, introduced to the Prussian Army by the military reformer Gerhard von Scharnhorst, arranged for giving recruits a short period of training, which in the event of war could be considerably expanded. With this the reduction of the army's strength did not have the desired effect, and in the following wars Prussia was able to draw up a large number of trained soldiers. The system was retained by the Imperial German Army into the First World War.
Both teams were fielded in "A" Grade. From the Association's point of view the split did not have the desired effect, as the teams were Premiers and Runners-up in 1928-29 and 30, and were only beaten by each other, making a record of seven years unbeaten by any other club. At this time also the Club had created what was believed then to be a world's record for any field game - twelve successive "A" Grade Premierships. The Diehards have played in a fixture competition under the auspices of Brisbane Hockey Association Inc.
Sima Yong tried to appease possible opposing forces by promoting all of the major princes and warlords, but his promotions did not have the desired effect. Meanwhile, Han Zhao attracted those Han and non-Han agrarians and tribesmen disappointed in Jin rule, and began to grow in size and power. At the same time, however, the Jin infighting continued. In the fall of 305, Sima Yue declared yet another rebellion, this time against Sima Yong, claiming that Sima Yong had improperly forced Emperor Hui to move the capital.
In 2002 the team changed its name from the Bay Area CyberRays to the San Jose CyberRays, and also gave their roster a facelift, allowing Murray to retire and trading for Pretinha from the Washington Freedom, who along with Katia and Sissi, gave the new attack a decidedly Brazilian flavor. The bold changes didn't have the desired effect, however, and the team finished out of the playoffs. One bright spot was the emergence of Katia, who scored 15 goals and broke Tiffeny Milbrett's record for most points in a season.
His mother is a major figure throughout the entire work.) His older brother Elyahu, recently married, tries to lift the family out of poverty through a series of get-rich-quick schemes he learns from a book, to which Motl is a willing accomplice. However, this effort does not have the desired effect. Together with a group of friends, they depart for America. (It is later told that some time after their departure, Kasrilevke was the target of a particularly severe pogrom, impelling many of the family's neighbors to follow them to America).
Icelandic law defines sexual harassment very broadly, essentially including any activity that is perceived as disrespectful. Those who consider themselves to have been harassed can report incidents to the Complaints Committee on Equal Status. While Icelandic courts have the power to issue restraining orders, critics have complained that such orders did not have the desired effect because they were granted too infrequently and took too long to be issued. Victims of sexual harassment have the right to be represented by lawyers, but most such victims choose not to take legal action.
He is roundly beaten up by Masters, is driven off the ranch and takes refuge with a Mexican. After the departure of the rest of the guests, Masters sets himself to the task of crushing the proud spirit of Avice but with little success. His best friend, Keno Clark and Avice's brother, thinking to assist in the happy ending, try to arouse Avice's jealousy by hinting of another woman in the life of Masters. This however, fails to have the desired effect, for Avice announces her intention of returning East and never setting eyes on her husband again.
Where and when it is/was in common use, tripelennamine is used much like other mildly-anticholinergic antihistamines to treat conditions of the upper respiratory tract arising from illnesses and hay fever. It can be used alone or in combination with other agents to have the desired effect. Cough medicines of the general formula tripelennamine + codeine/dihydrocodine/hydrocodone ± expectorant ± decongestant(s) are popular where available. Among these are the Pyribenzamine cough syrups which contain codeine, with and without decongestants, listed in the 1978 Physicians' Desk Reference; the codeine-tripelennamine synergy is well-known and makes such mixtures more useful for their intended purposes.
Brisbane would recover to enter a playoff for the 5th and final spot in the finals, but lost 38–14 to the Cronulla Sharks, ending their season. Leading up to the 1990 season, Brisbane recruited Kevin Walters from Canberra. However, the biggest news was the decision of Bennett to remove Lewis as club captain on the basis that he wasn't a good trainer or teammate, with Miles resuming the captaincy of the side. While the move was controversial, it seemed to have the desired effect, as the Broncos finished the season in 2nd, qualifying for their maiden finals series.
On 9 July 1807 in the Treaty of Tilsit, Napoleon forced Prussia to drastically reduce its military strength, in addition to ceding large amounts of territory. The Prussian army could no longer be stronger than 42,000 men. The Krümpersystem, introduced to the Prussian army by the military reformer Gerhard von Scharnhorst, arranged for giving recruits a short period of training, which in the event of war could be considerably expanded. With this the reduction of the army's strength did not have the desired effect, and in the following wars Prussia was able to draw up a large number of trained soldiers.
Whilst at Stalag Luft III he met Talbot Rothwell, who later went on to write many of the Carry On films in which Butterworth was to star. Having never performed in public before his imprisonment, Butterworth formed a duo with Rothwell and sang in the camp shows. They delivered a song which Rothwell called "The Letter Edged In Black". The performance was followed by some comic repartee which, according to Butterworth's account, provoked enough boos and hisses to have the desired effect of drowning out the sounds of an escape tunnel being dug by other prisoners‘ escape party.
Morton's strategy in the courtroom is to argue that slums breed criminals and that society is partly to blame for crimes committed by people who are forced to live in such miserable conditions. Morton argues that Romano is more a victim of society than a natural-born killer. Yet, his strategy does not have the desired effect on the jury, thanks to the badgering of the seasoned and experienced District Attorney Kernan (George Macready), who delivers question after question until Nick shouts out his admission of guilt. Morton, who actually believed in his client's innocence, is shocked by Nick's confession.
Operation Shingle, an amphibious assault at Anzio behind the line was intended to break it, but did not have the desired effect. The line was eventually broken by frontal assault at the Fourth Battle of Monte Cassino in the Spring of 1944 and Rome was captured in June. Following the fall of Rome, the Normandy landings (6 June 1944) that began Operation Overlord and the Red Army victories on the Eastern Front, the Italian campaign became of secondary importance to both sides. The Gothic Line north of Rome was not broken until the Spring offensive of 1945.Clark, p. 1.
Stephen Sears, the author of the To The Gates of Richmond, described the demonstrations of his limited troops, which included marching back and forth behind the lines with great fanfare to appear to be a larger force, as "performances of the Prince John Players." Magruder's efforts appeared to have the desired effect, as the ever-cautious McClellan moved very slowly with his forces, which were actually substantially larger than those of the defenders. Meanwhile, a long defensive line was being built outside Richmond. Fort Magruder, actually an elaborate but earthen fortification, was named for General Magruder.
This did not have the desired effect. Instead of returning and occupying the land they were thus able to claim, the Boers more often than not sold it to speculators, sometimes at prices as low as 1d or2d an acre, and withdrew permanently beyond the Drakensberg. Thus the Government had very little left in the way of Crown lands in sufficiently large blocks to allow the settlement of large numbers of emigrants. Then his lot plan was quite unrealistic, taking into account the Natal countryside - there was no way an immigrant could make a living here on .
However, this did not have the desired effect mostly because of political instability. The Porfirio Díaz regime of the decades before the Mexican Revolution tried again, and expressly desired European immigration to promote modernization, instill Protestant work ethics and buttress what remained of Mexico's North from further U.S. expansionism. Díaz also expressed a desire to "whiten" Mexico's heavily racially mixed population, although this had more to do with culture than with biological traits. However, the Díaz regime knew it had to be cautious, as previously large concentrations of Americans in Texas, would eventually lead to the secession of that territory.
Unfortunately the changes did not have the desired effect and in a disappointing game Dykehead left with both points after a 2-1 win. After two home defeats it was hoped that Dumbarton’s third home fixture on the trot would bring better results. Three new faces were introduced – Richard Oldcorn in goal and Francis McCormack on the left wing who had both impressed in the Qualifying Cup tie for Carfin despite the result, and McHarg (ex Ayr Parkhouse). The opponents were Ayr Parkhouse and on the day Dumbarton got back into winning ways with a 4-0 victory – and that despite losing McCallum to injury 10 minutes into the second half.
John Locke by Richard Westmacott, University College, London Locke, writing his Letters Concerning Toleration (1689–1692) in the aftermath of the European wars of religion, formulated a classic reasoning for religious tolerance, in which three arguments are central:McGrath, Alister. 1998. Historical Theology, An Introduction to the History of Christian Thought. Oxford: Blackwell Publishers. pp. 214–15. # Earthly judges, the state in particular, and human beings generally, cannot dependably evaluate the truth-claims of competing religious standpoints; # Even if they could, enforcing a single 'true religion' would not have the desired effect, because belief cannot be compelled by violence; # Coercing religious uniformity would lead to more social disorder than allowing diversity.
The following year, Spear and a handful of followers retreated to a wooden shed at the top of High Rock Hill in Lynn, Massachusetts, where they set to work creating the "New Motive Power", a mechanical Messiah which was intended to herald a new era of Utopia. The New Motive Power was constructed of copper, zinc and magnets, all carefully machined, as well as a dining room table. At the end of nine months, Spear and the "New Mary", an unnamed woman, ritualistically birthed the contraption in an attempt to give it life. Unfortunately for Spear, this failed to have the desired effect, and the machine was later dismantled.
The largest of these expeditions was the Sullivan Expedition of 1779, in which American colonial troops destroyed more than 40 Iroquois villages to neutralize Iroquois raids in upstate New York. The expedition failed to have the desired effect: Native American activity became even more determined. Mishikinakwa ("Little Turtle")'s forces defeated an American force of nearly 1000 U.S Army soldiers and other casualties at the Battle of the Wabash in 1791. The British made peace with the Americans in the Treaty of Paris (1783), through which they ceded vast Native American territories to the United States without informing or consulting with the Native Americans.
In her first letter to the General Court, Dyer used the themes of agency and allegiance in creating an analogy between her witnessing in Massachusetts with the Book of Esther. Esther, a Jew, was called upon to save her people after the evil Haman urged the king to enact a law to have all Jews put to death. It was Esther's intercession with the king that saved her people, and the parallels are that Dyer is the beautiful Esther, with wicked Haman representing the Massachusetts authorities, and the Jews of the Bible being the Quakers of Dyer's time. Ultimately, Dyer's martyrdom did have the desired effect.
Sensing these feelings, Charles III of Spain progressively eased the trade restrictions and finally declared Buenos Aires an open port in the late 18th century. The capture of Porto Bello by British forces also fueled the need to foster commerce via the Atlantic route, to the detriment of Lima-based trade. One of his rulings was to split a region from the Viceroyalty of Perú and create instead the Viceroyalty of the Río de la Plata, with Buenos Aires as the capital. However, Charles's placating actions did not have the desired effect, and the porteños, some of them versed in the ideology of the French Revolution, became even more convinced of the need for independence from Spain.
Sexual harassment, by definition, is unwanted and not to be tolerated. There are ways, however, for offended and injured people to overcome the resultant psychological effects, remain in or return to society, regain healthy feelings within personal relationships when they were affected by the outside relationship trauma, regain social approval, and recover the ability to concentrate and be productive in educational and work environments. These include stress management and therapy, cognitive- behavioral therapy, friends and family support, and advocacy. Immediate psychological and legal counseling are recommended since self-treatment may not release stress or remove trauma, and simply reporting to authorities may not have the desired effect, may be ignored, or may further injure the victim at its response.
He reasons that if anything at all gets done in the organization it's probably because people are forging signatures they'd have to wait forever to get. His deskmate just says "You can't beat the system." The middle of the story tells the tale of how the new order progresses through the system, with officials inspecting the factory making the irradiator to see that it is indeed a real and properly patriotic business, and other officials creating official documents stating that the irradiator will indeed have the desired effect on the insects and so on and so forth. In record time, that is to say mere years, the irradiator arrives, and immediately the bureaucrats smell a rat.
Stuart, , the United States Supreme Court overturned such a "gag order". It ruled that alternative methods to help ensure a fair trial, short of prior restraints, might have been used, and that it was not all clear, under the circumstances, that the gag order would have the desired effect even if upheld. It also made a particular point of asserting that orders restricting reporting on events that occur in open court are not permissible. It wrote: > To the extent that this order prohibited the reporting of evidence adduced > at the open preliminary hearing, it plainly violated settled principles: > '[T]here is nothing that proscribes the press from reporting events that > transpire in the courtroom.
The proposed change is a reaction to pressure from the international furniture industry supported by manufacturers of decorative arts: copyright holders of many famous and much copied 20th century furniture design classics such as the Egg Chair and Barcelona Daybed hope that long expired copyright periods will be revived allowing for a further period of commercial exploitation.Impact Assessment Report dated 15 May 2012 carried out by the Intellectual Property Office. Some legal commentators have doubted whether the legislation will have the desired effect. They contend that many mass-produced items of 20th-century industrial furniture may not be defined by the courts of the United Kingdom as works of artistic craftsmanship but as mere designs.
This required the extension of rationing, as British goods and produce were prioritized for export markets. Unlike Continental European countries, where rationing was abandoned within a few years of the wars' end, Britain actually tightened rationing restrictions and didn't fully abandon them until 1954. The U.S. began Marshall Plan grants (mostly grants with a few loans) that pumped $3.3 billion into the economy and encouraged businessmen to modernize their approach to management.Michael J. Hogan, The Marshall Plan: America, Britain and the Reconstruction of Western Europe, 1947-1952 (1989) Marshall Aid, however, failed to have the desired effect of modernizing industry and stimulating the economy, because 97% of the funds were used to service British debt repayments.
Simultaneously, Zobelle almost immediately tried to undermine SAMCRO's iron-fisted rule over the town and threatened dire consequences against the club if they ignored his warnings. He made it clear that his mission was to stop SAMCRO from selling guns to minority gangs and to take over their territory by trying to bring down the MC at any cost, no matter what method his gang has to use. After Clay Morrow, SAMCRO's President, refused to stop selling to minorities, Ethan had Clay's wife, Gemma Teller Morrow, brutally raped and beaten; she was instructed to tell Clay what happened and to stop his dealings with minorities or she would be assaulted again. This did not have the desired effect, as Gemma did not tell Clay of the rape.
By the end of June, some twenty pumps had been assembled on the scene, with a total pumping capacity of of water per hour. Difficulties with pumping, owing in part to the subdivision of the internal compartments and the need to reflood the ship during high tide to keep her from suffering more damage before the hull could be patched, led the salvors to give up the operation. Wilson next sought to remove armour plate from the sides of the ship and to erect a series of caissons, at which point a powerful air pump would be used to blow the water out of the hull. The caissons repeatedly broke free even in mild seas, and the air pump failed to have the desired effect.
PSM helps employees get the most out of their job experience and is rapidly evolving to work towards employee goals and organizational needs effectively. Efforts to manage employee behavior within government organizations by focusing on financial rewards may not have the desired effect and could potentially have a negative impact on employee motivation and performance seeing as how those that do work in the public sector are usually not motivated by financial gain. According to Perry, PSM in today's society is more about focusing on employee commitment to an organization rather than benefits of a higher salary. One way PSM output can be measured is by team performance which encourages individuals to engage in behaviors that are best for the team's success and productivity.
However, Thích Trí Quang's supporters appeared unwilling to wait for Kỳ's schedule, calling for the Constituent Assembly that would draft the new constitution to be chosen from provincial and city councils, where Buddhists did well in elections, but Kỳ refused. Kỳ brought loyalist marines and paratroopers from Saigon to Da Nang to try and cow the dissidents, but this did not have the desired effect, so he returned to Saigon to meet Buddhist leaders for negotiations. The Buddhists demanded an amnesty for rioters and mutinous soldiers, and for Kỳ to withdraw the marines from Da Nang back to Saigon where they formed part of the strategic reserve. However, Thích Trí Quang maintained a firm position on the constitution and the protests continued.
Moreover, even if Joe achieves his best possible outcome and changes the block to O, Jane will still aim for this block to change it to X. Joe's move is essentially wasted. Instead, Joe aims for one of Jane's established corners. If he hits it, there is a 2-in-3 chance that he will remove the X from the board, and he even has a 1-in-3 chance to flip the square to O, radically altering Jane's strategy. While no method of tossing the beanbag is guaranteed to have the desired effect, tossing the bag vertically (such that it rotates corner over corner) rather than horizontally (such that it stays mostly flat) tends to create more significant impacts and more often turns the blocks.
Only a court of ordained judges could try an action for injury to the person, according to the rules mentioned down above, and give judgment for a definite sum. As judges could only be lawfully ordained in the Land of Israel, judgments for damage and pain could not be collected, even in Babylonia.Bava Kamma 84a But, as a matter of necessity, a system was worked out which soon spread over all countries in which the Jews enjoyed any sort of autonomy. When parties complained of injuries, the judges, after hearing their allegations and the testimony of witnesses, indicated the sum that in their opinion the assailant should pay, and, upon his refusal, would threaten him with excommunication (') and this course would generally have the desired effect.
Letter from Tessmar to assorted commanders (in German), 8 May 1916 Furthermore, the government introduced rationing and price controls to counteract the soaring demand and to make food more affordable for poorer Luxembourgers. However, the measures did not have the desired effect. Increasing numbers of Luxembourgers turned to the black market, and, to the consternation of the Luxembourgish government, the German army of occupation seemed to do little to help. Moreover, the government accused Germany of aiding the development of the black market by refusing to enforce regulations, and even of smuggling goods themselves. Through 1916, the food crisis deepened, compounded by a poor potato harvest across all of the Low Countries; in neighbouring Belgium, the harvest was between 30% and 40% down on the previous year.
0.1 localhost ::1 localhost The name may also be resolved by Domain Name System (DNS) servers, but queries for this name should be resolved locally, and should not be forwarded to remote name servers. In addition to the mapping of localhost to the loopback addresses ( and ), localhost may also be mapped to other IPv4 (loopback) addresses and it is also possible to assign other, or additional, names to any loopback address. The mapping of localhost to addresses other than the designated loopback address range in the hosts file or in DNS is not guaranteed to have the desired effect, as applications may map the name internally. In the Domain Name System, the name localhost is reserved as a top-level domain name, originally set aside to avoid confusion with the hostname used for loopback purposes.
The conservative Reid government was suffering damage to its popularity as a result of the Great Depression, and radical economic theories, most notably the version of social credit espoused by Calgary evangelist William Aberhart, were gaining currency among the public. The government's position was that Aberhart's proposals were beyond the legal authority of the provincial government, since they involved banking, which the Constitution of Canada makes a responsibility of the federal government. As attorney-general, Lymburn played a major role in defending this position. When the government brought social credit founder C. H. Douglas from the United Kingdom as an advisor, Lymburn provided him with a copy of one of Aberhart's speeches and asked him to critique it; Douglas concluded that Aberhart's proposals did not align with "Douglasite" social credit, and that many of them would not have the desired effect.
It was claimed that while pregnant with Richard and Griselda, Steevens' mother had said "take away your litter of pigs!" to a woman beggar asking for money to feed her children, and Griselda had then been born with the head and face of a pig. Dismayed by the popular belief that she had a pig's head, Griselda took to sitting on an open balcony to allow the public to see her face. This failed to stem the spread of the rumour, and she commissioned a portrait of herself to be hung in the main hall of the hospital. The portrait failed to have the desired effect; many of the public chose instead to believe a portrait in a pub neighbouring the hospital, which showed Steevens with a pig's head; the pub also displayed a silver trough alleged to have belonged to her.
After negotiation with the Brazilian government, South African trade and industry minister Rob Davies declined to implement the ITAC recommendations. He acknowledged the stiff competition that South African producers faced from Brazil, but said that there was need for a more “comprehensive strategy” that dealt with all poultry exporters to South Africa, to the dismay of the SAPA. Instead of definitive anti-dumping duties, South Africa chose to impose import tariffs of up to 82% (up from 27%) on all poultry products originating from countries from which South Africa has no preferential trade arrangements, on the basis that the domestic industry was affected by all chicken imports, not only those from Brazil. Davies acknowledged the need to protect South African producers, but said that the antidumping duties had failed to have the desired effect, and that a general tariff increase would likely be more effective.
Drake's men saw weathered and bleached skeletons on the grim Spanish gibbets and decided to remain in San Julian for the winter before attempting the Strait of Magellan. Whilst in San Julian Drake finally made the decision to try Doughty with treachery and an incitement to mutiny. The main pieces of evidence against Doughty were the testimony of the ship's carpenter, Edward Bright, who after the trial was promoted to master of the ship Marigold, and Doughty's admission of telling Lord Burghley, a vocal opponent of agitating the Spanish, of the intent of the voyage. Drake consented to his request of Communion and dined with him along with Francis Fletcher who had this strange account: The trial eventually found Doughty guilty, but only on the mutiny charge but on 2 July at Drake's insistence, Doughty was beheaded, but this stern example did not have the desired effect.
In addition, with the influx of talented painters from the Southern Netherlands cities such as Antwerp, the guild fathers felt that more protective measures were necessary. When securing a new protective charter for the St. Luke's guild failed to have the desired effect, the Confrerie Pictura was set up by 48 dissatisfied painters.Confrerie Pictura in De groote schouburgh der Nederlantsche konstschilders en schilderessen (1718) by Arnold Houbraken, courtesy of the Digital library for Dutch literature They were led by the first deacon and popular Hague portrait painter Adriaen Hanneman.Dutch article on the history of the arts in the Hague Among the founders were Willem Doudijns (1630–1697), Jacob van der Does (1623–1673), Jan de Bisschop (1628–1671), Theodor van der Schuer, Dirck van der Lisse, Daniel Mijtens the Younger, Johannes Mytens, Willem van Diest, Adriaen van de Venne, Robbert Duval, Joris van der Haagen and Augustinus Terwesten.
Allied attempts to stop Turkish sales of chromium had begun to have the desired effect, however. In November 1943 Albert Speer declared that without its Turkish chromium imports, Germany's armaments manufacture would come to a halt within 10 months, and Allied threats to subject Turkey to the same economic warfare measures used against other neutrals eventually persuaded her to cease the exports to Germany by April 1944. Though Germany, with the resources of the conquered territories was still able to produce three times as much steel as Britain,UK National Archives MEW Committee report as a result of military action she was beginning to lose other sources of special metals which could not be replaced. On the eastern front, the Red Army had taken back its manganese mines at Balki, from which the Germans had been getting 200,000 of the 375,000 tons their war industry required each year.
CBC News interactive feature on political attack ads However, Campbell's decision caused sharp disagreements between her and her campaign staff. Tory, Gregg, and Segal felt that pulling the ad would validate all of the attacks against it and those in the Tory party who produced it, as well as leaving an impression that the Tories did not know what they were doing. They also argued that leaving the ad on the air would be far less harmful, and that in time the full slate of attack ads would have the desired effect of lowering Chrétien's personal popularity. Additionally, they pointed out that not only were many newspapers and magazines using photos highlighting Chrétien's facial deformity that were similar to those used in the ad, Chrétien himself had used his half-paralyzed face in the campaign (Liberal advertisements in Quebec used a phrase translated into English as "Strange-looking face, but reflect on what's inside").
The Capitals changed coaches during the offseason, bringing in local Brazilian-born coach Helio d'Anna, but his introduction failed to have the desired effect, as the team again suffered from raging inconsistency, especially away from home. They actually won their opening game of the 2008 campaign, 2–0 over the El Paso Patriots off a pair of goals by Tony Judice, but immediately slumped to three successive defeats in their next three games. They won the first half of the Louisiana derby, 4–1 at home over the New Orleans Shell Shockers, and enjoyed a brief run of form at the beginning of June, knocking off Houston Leones and Mississippi Brilla in quick succession, but rapidly reverted to their old ways; they didn't win another game that month, suffering a trio of 3-goal defeats, and were eliminated from playoff contention with several games remaining in the season. They did manage to do the double over their state rivals, beating New Orleans 3–2 in the return fixture in the Big Easy with two goals from Leonardo dos Barros, but eventually finished the year a distant fifth in the Mid South, 9 points adrift of divisional champions Austin Aztex U23.

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