"Look at this airport, built by Arabs!" he exclaims as the family disembarks in Tripoli, ignoring the cigarette butts freckling the ground.
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In phenotyping, scientists scan a person's genes for variations known to influence traits like skin color, eye color, geographical ancestry and freckling.
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Q: Thanks to my red-headed mother and blond father, I am pale as a newt and prone to freckling and sunburn.
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Two computer-generated images were created using predictions of the suspect&aposs ancestry, eye color, hair color, skin color, freckling, and face shape.
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The traits derived from the DNA can predict a person's ancestry, eye color, hair color, skin color, freckling and face shape, police said.
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"Individual predictions were made for the subject's ancestry, eye color, hair color, skin color, freckling and face shape," Gulluni said at a press conference.
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They are sized to fit in your palm and slightly sweet, with a crisp patch on the bottom and a freckling of black sesame seeds on top.
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I am forced to see what they see: His skin is darker and his hair wavy, while I'm fair, prone to freckling, with hair that won't hold a curl.
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In 2015, the police in North Carolina arrested a man on two counts of murder after crime-scene DNA indicated the killer had fair skin, brown or hazel eyes, dark hair, and little evidence of freckling.
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Read more: There's a dating trend called 'freckling' and you're not going to like itThough the series will run on Tinder first, producers are considering whether to air it on a traditional streaming or broadcast platform further down the line, according to Variety.
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Anyway, a lot of "summer truthers"—people who actually enjoy eating their lunch outside and away from their desk, for instance, people who glow with the healthy lacquer of a tan instead of freckling up like a storm, people who enjoy drinking cool juice-based cocktails by open-air pools—a lot of these summer truthers have been swinging for me, saying my opinions re: summer are bad, that they are wrong, that I am incorrect in a very deep and fundamental part of me, that everything I thought I knew is wrong.
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Childhood tumor syndrome is a condition characterized by axillary freckling, neurofibromas and/or CNS gliomas.
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Axillary freckling also occurs in other disease processes that closely resemble NF1, such as Legius syndrome (cafe-au-lait spots, axillary freckling, and macrocephaly without Lisch nodules, neurofibromas or CNS tumors), and, homozygous HNPCC mutations (cafe-au-lait spots, axillary freckling, and cutaneous neurofibromas in the setting of Hereditary Non-Polyposis Colon Cancer, also known as Lynch syndrome; seen with family history of HNPCC and consanguinity)K Jett, JM Friedman. Clinical and Genetic Aspects of Neurofibromatosis 1. Genetics in Medicine 12(1):1-11. January 2010.
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The MC1R gene is also associated with red hair more strongly than with freckles. Most red-haired individuals have two variants of the MC1R gene and almost all have one. The variants that cause red hair are the same that cause freckling. Freckling can also be found in areas, such as Japan, where red hair is not seen.
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Charles C Thomas, Publisher, 301–327 E. Lawrence Ave., Springfield, Ill., 1956. In 1964 Crowe published work on the use of axillary freckling in its diagnosis, which is now referred to as the Crowe sign.
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Watson syndrome is an autosomal dominant condition characterized by Lisch nodules of the ocular iris, axillary/inguinal freckling, pulmonary valvular stenosis, relative macrocephaly, short stature, and neurofibromas. Watson syndrome is allelic to NF1, the same gene associated with neurofibromatosis type 1.
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The preserve specimen of the Galápagos petrel displays dark-gray upperparts and white underparts with some black freckling on the face. The brown tinge is due to abrasion. It also has a hooked bill that is adapted for manipulating their prey. The Galápagos and Hawaiian petrel are really similar.
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The posterior parts of the venter are largely transparent. Females have dusky specklings or freckling on the throat; this may extend to the breast. Males have dusky to black throat and a cream-color patch across the belly at the midbody; when deflated, the vocal sac often forms a transverse fold.
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A deficiency of excinuclease occurs in a rare autosomal recessive disease called xeroderma pigmentosum. Diagnosis of this disease is done by measuring the enzyme's level in white blood cells in a blood sample. Symptoms in children include extreme UV sensitivity, excessive freckling, multiple skin cancers and corneal ulcerations. Typically, these symptoms are seen during a child's first sun exposure.
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There is a feeble to very pronounced pattern of grey or green to dark brown or black blotches, spots and freckling. These markings form a more or less discernible triangle or rectangle. A series of irregular blotches is usually present in the sacral region. Limbs have transverse bars that may or may not be well-defined.
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Alcohol-preserved specimens are dorsally grey- brown; a paler vertebral line, stripe, or broad mid-dorsal band may be present. Dorsal pattern usually consists of very obscure blotching, spotting, and freckling. Adult males have strongly darkened throat, whereas throat of females is more or less profusely sprinkled with melanophores, either uniformly or clustered to form mottling or vermiculation.
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Lifetime cumulative UV exposure to skin is also responsible for significant age-associated dryness, wrinkling, elastin and collagen damage, freckling, age spots and other cosmetic changes. The American Academy of Dermatology advises that photoprotective measures be taken, including the use of sunscreen, whenever one is exposed to the sun.American Academy of Dermatology. Position statement on vitamin D. November 1, 2008.
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The freckled nightjar is a large, powerfully-build species of nightjar with long wings and relatively short tails. They lack any prominent markings and appear dark gray or nearly black from a distance. At closer range, white, cinnamon, and pale buff freckling is visible on the upperparts of adults. Their underparts are typically dark brown with a whitish and cinnamon barring pattern.
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The disorder presents at infancy or early childhood. Xeroderma pigmentosum mostly affects the eye and skin. Individuals with XP have extreme sensitivity to light in the ultraviolet range starting from one to two years of age, and causes sunburn, freckling of skin, dry skin and pigmentation after exposure. When the eye is exposed to sunlight, it becomes irritated and bloodshot, and the cornea becomes cloudy.
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Uneven pigmentation of some sort affects most people, regardless of bioethnic background or skin color. Skin may either appear lighter, or darker than normal, or lack pigmentation at all; there may be blotchy, uneven areas, patches of brown to gray discoloration or freckling. Apart from blood-related conditions such as jaundice, carotenosis, or argyria, skin pigmentation disorders generally occur because the body produces either too much or too little melanin.
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By comparison, mottling associated with the Leopard complex is large and blocky alternations between true black or charcoal-colored skin and pigmentless-pink skin. The skin of cremellos and perlinos is pigmented-pink, and exhibit a scant few tiny black specks. Homozygous pearls and pearl-cream combinations also exhibit some freckling of the skin, however this is muted in comparison to the freckles of champagne skin. The skin may exhibit an overall lavender tone.
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Melanin in the skin aids UV tolerance through suntanning, but fair-skinned persons lack the levels of melanin needed to prevent UV-induced DNA-damage. Studies have shown that red hair alleles in MC1R increase freckling and decrease tanning ability. It has been found that Europeans who are heterozygous for red hair exhibit increased sensitivity to UV radiation. Red hair and its relationship to UV sensitivity are of interest to many melanoma researchers.
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Ultraviolet light (UVA) treatments are normally carried out in a hospital clinic. Psoralen and ultraviolet A light (PUVA) treatment involves taking a drug that increases the skin's sensitivity to ultraviolet light, then exposing the skin to high doses of UVA light. Treatment is required twice a week for 6–12 months or longer. Because of the high doses of UVA and psoralen, PUVA may cause side effects such as sunburn-type reactions or skin freckling.
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The red phase is often nearly solid reddish to neon pumpkin orange, and the yellow phase is in or near a neon- range. Females are a more pale color than the males, showing more tan variations of the coloring and much less belly coloring as well as less vivid patterns, most females having a simple "freckling" on the back. "Saharans" are medium-sized lizards, many averaging in total length, and weighing or more as adults.
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Clutch size is usually 1 or 2 but up to 3 eggs in a clutch have been reported in Japan. It is claimed that one egg is considered the norm in most of the range, as is invariably the case in the related changeable hawk-eagle. The egg is pale clay-colored or reddish in colour with varied freckling of darker red or pure white, and often with blotches and spots of red at the large end.
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These individuals have the variant Val92Met which is also found in white people, although it has minimal effects on their pigmentation. The R162Q allele has a disputed involvement in freckling. The variants of the MC1R gene that are linked with freckles started to emerge in the human genotype when humans started to leave Africa. The variant Val92Met arose somewhere between 250,000 and 100,000 years ago, long enough for this gene to be carried by humans into central Asia.
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In 1956 Crowe et al. recognised the autosomal dominant heredity of neurofibromatosis and the use of 6 or more café au lait spots to diagnose the condition. In 1964 Crowe published work on the use of axillary freckling in its diagnosis, which is now referred to as the Crowe sign. He noticed that axillary freckles are present in about 20-30% of patients with neurofibromatosis, but he did not see any in patients who did not have neurofibromatosis.
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Leopard complex has a different mottling pattern from champagne's freckling pattern Leopard vs. Champagne: The Leopard complex is responsible for the spotted coat of the Appaloosa and other breeds. Even when a spotted hair coat is absent, other traits produced include mottled skin and a white sclera around the eye but generally the eye itself is dark brown. These mottles are alternations between unpigmented pink skin and pigmented skin, which is usually black (thus the mottles are black on a pink background).
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The population that is affected by this mutation has a high familial history of melanoma or atypical moles and birth marks in large numbers, a history of primary melanoma/cancers in general, immunosuppression, skin that burns easily and doesn't tan, freckling, blue eyes, red hair, or a history of blistering. People with these high risk factors are more likely to carry inherited mutations in CDKN2A. For those who have a gene mutation, the severity is also dependent on the environmental surroundings.
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ADULT syndrome features include ectrodactyly, syndactyly, excessive freckling, lacrimal duct anomalies, dysplastic nails, hypodontia, hypoplastic breasts and nipples, hypotrichosis, hypohidrosis, broad nasal bridge, midfacial hypoplasia, exfoliative dermatitis, and xerosis.Avitan- Hersh, E., Indelman, M., Bergman, R., & Sprecher, E. (2010). ADULT syndrome caused by a mutation previously associated with EEC syndrome Wiley-Blackwell. doi:10.1111/j.1525-1470.2010.01131.x The lack of facial clefting and ankyloblepharon are important because they exist in ectrodactyly–ectodermal dysplasia–cleft syndrome (EEC) but not in ADULT syndrome.
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A. brevilinea Fenn (49 d). Forewing dull grey brown densely black- dusted; the veins terminally paler; inner and outer lines represented by a series of dark vein dots; a black streak from base below cell: hindwing fuscous, darker towards termen; an outer row of dark dots; the ab. sinelinea Farn (49 d) is more uniform in coloration, without the black streak from base. Larva pale ochreous, with brown freckling; dorsal, subdorsal, and spiracular lines orange edged with yellow; head pale brown.Warren.
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Xeroderma pigmentosum (XP) is a genetic disorder in which there is a decreased ability to repair DNA damage such as that caused by ultraviolet (UV) light. Symptoms may include a severe sunburn after only a few minutes in the sun, freckling in sun exposed areas, dry skin and changes in skin pigmentation. Nervous system problems, such as hearing loss, poor coordination, loss of intellectual function and seizures, may also occur. Complications include a high risk of skin cancer, with about half having skin cancer by age 10 without preventive efforts, and cataracts.
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Neurofibromas are often asymptomatic, unless they exert pressure on areas of the body, such as the spinal chord nerve roots. These tumours may disfigure the appearance of affected areas, as does skin hyperpigmentation, which is common in this condition. Non-tumour characteristics of Neurofibromatosis Type I include café-au-lait spots, skin fold freckling, Iris Lisch nodules and optic glycoma in the eye, and skeletal displasias. Less common complications include epilepsy and learning impairments, with studies finding at least half of children with Neurofibromatosis Type I suffer from learning difficulties, many with attention deficit disorder.
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Women with freckles The presence of freckles is related to rare alleles of the MC1R gene, though it does not differentiate whether an individual will have freckles if they have one or even two copies of this gene. Also, individuals with no copies of the MC1R do sometimes display freckles. Even so, individuals with a high number of freckling sites have one or more of variants of the MC1R gene. Of the variants of the MC1R gene Arg151Cys, Arg160Trp, and Asp294His are the most common in the freckled subjects.
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The Crowe sign or Crowe's sign is the presence of axillary (armpit) freckling in people with neurofibromatosis type I (von Recklinghausen's disease). These freckles occur in up to 30% of people with the disease and their presence is one of six diagnostic criteria for neurofibromatosis. Freckles can also be present in the intertriginous area in neurofibromatosis, such as the inguinal fold, submamillary areas and nape of the neck. This medical sign is named after Frank W. Crowe (July 2, 1919-April 29, 1987), an American physician who practiced Dermatology in Boise, Idaho.
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Frank Wilkinson Crowe (July 2, 1919 - April 29, 1987) was an American physician, who practiced Dermatology in Boise, Idaho. He was a world-renowned authority for the Crowe sign or Crowe's sign in neurofibromatosis which is the presence of axillary (armpit) freckling in people with neurofibromatosis type I (von Recklinghausen's disease). These freckles occur in up to 30% of people with the disease and their presence is one of seven diagnostic criteria for neurofibromatosis. Freckles can also be present in the intertriginous area in neurofibromatosis, such as the inguinal fold, submamillary areas and nape of the neck.
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She described the "needle marks freckling the baby-smooth skin of his thin, brown arms." The story engendered much empathy among readers, including Marion Barry, then mayor of Washington, D.C. He and other city officials organized an all-out police search for the boy, which was unsuccessful and led to claims that the story was fraudulent. Barry, responding to public pressure, lied and claimed that Jimmy was known to the city and receiving treatment; Jimmy was announced dead shortly thereafter. Although some within the Post doubted the story's veracity, the paper defended it and assistant managing editor Bob Woodward submitted the story for the Pulitzer Prize.
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Reportedly, in some populations the female may be slightly darker on average than the male. The plumage coloration across at least 13 accepted subspecies can be highly variable. The upper parts may be brown-black to tawny-buff to pale creamy gray, typically showing dense freckling on the forehead and crown, stripes on the nape, sides and back of the neck, and dark splotches on the pale ground colour of the back, mantle and scapulars. A narrow buff band, freckled with brown or buff, often runs up from the base of the bill, above the inner part of the eye and along the inner edge of the black-brown ear tufts.
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Up to 50% of UVA can penetrate deeply into the dermis in persons with light skin pigmentation with little protective melanin pigment. The characteristic of fair skin, red hair, and freckling is associated with high amount of pheomelanin, little amounts of eumelanin. This phenotype is caused by a loss-of-function mutation in the melanocortin 1 receptor (MC1R) gene. However, variations in the MC1R gene sequence only have considerable influence on pigmentation in populations where red hair and extremely fair skin is prevalent. The gene variation’s primary effect is to promote eumelanin synthesis at the expense of pheomelanin synthesis, although this contributes to very little variation in skin reflectance between different ethnic groups.
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" Champagne differs from Dun in that it affects the color of the coat, skin, and eyes, and in that the unaffected condition is the wildtype. Horses with the dominant CH allele (CH/CH or CH/ch genotype) exhibit hypomelanism of the body coat, such that phaeomelanin is diluted to gold and eumelanin is diluted to tan. Affected horses are born with blue eyes which darken to amber, green, or light brown, and bright pink skin which acquires darker freckling with maturity.Cook et al. 2008. "...champagne foals are born with blue eyes, which change color to amber, green, or light brown and pink “pumpkin skin which acquires a darker mottled complexion around the eyes, muzzle, and genitalia as the animal matures.
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The wingspan is 28–33 mm. Forewing yellow, thickly freckled with orange; veins finely ferruginous; lines ferruginous brown, the median thick; all running more or less parallel to each other and to termen; the inner oblique outwards from costa to subcostal vein and again from vein 1 to inner margin where it touches the median; stigmata of the ground colour, with brown rings; the orbicular large, round; both with brown centres; submarginal line formed of disconnected pale lunules edged inwardly with darker; hindwing pale yellow;- aurantiago Tutt is a darker form, deeper orange, and sometimes darkened by grey dusting, occurring in Britain: incolorata equally meriting a distinctive name is a rare form, ab. incolorata ab. nov. [Warren] in which the ground colour is pure pale ochreous, without any orange freckling, the veins and lines faintly brownish, the stigmata all but obsolete; the fringe pale; hindwing white; I have seen only 1 example, a female, certainly British, but without exact locality; the form subflava Ev., from Denmark, the Baltic, St. Fetersburg, and the Ural Mts.
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