Overcoming these feelings and kind of dissociating from shame and from these crazy emotive fits.
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My vision starts oscillating, not like I'm passing out; rather, like I'm dissociating from the world around me.
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Holly's grieving period includes dissociating from her friends and family as she comes to terms with her husband's death.
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She doesn't think she needs therapy; however, she finds herself dissociating from her body and traveling to Coney Island.
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As Freud has described, there are various ways of doing this: by repressing experience, dissociating from it, numbing it, turning away from it.
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P. C. Thakur, general manager of The Zen Ladakh hotel in Leh, hopes that dissociating from Jammu and Kashmir will further attract visitors.
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In an exclusive interview with Inside Edition, the 41-year-old mother of 14 talked about her dissociating from her nickname and what it's like raising her children in a three-bedroom town home outside of Los Angeles.
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At the Public Theater, "Chambre Noire," directed by Ms. Aspeli and Paola Rizza, depicts this in such devastatingly poetic imagery — a child dissociating from her body to endure a trauma — that it made me clap a hand to my mouth.
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By dissociating from one specific kind of product or area of focus, they can either push a new message or communicate to customers that they sell a wide range of items — all the better to grow and grow, per the demands of capitalism.
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" Asked whether lower inflation forecasts gave the bank a window of opportunity to further cut minimum reserve requirements, Isarescu said: "We are not dissociating from our medium-term targets ... but there is a possibility they could be slightly delayed or less clear.
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Some polymerases add over 50,000 nucleotides to a growing DNA strand before dissociating from the template strand, giving a replication rate of up to 1,000 nucleotides per second.
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Ziyarat Ashura contains concepts like tabarra (dissociating from those who oppose God, oppose the Islamic prophet Muhammad or oppose his family), tawalla (loving the Ahl al-Bayt), self-sacrifice for society, and never surrendering to tyranny and oppression.
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McFarland, 2009: 163. Henry B. Wonham notes a significance to Ryder's referring to 'Liza not simply as wife but "the wife of my youth", as if dissociating from her even as he acknowledges her.Wonham, Henry B. Playing the Races: Ethnic Caricature and American Literary Realism. New York: Oxford University Press, 2004: 168.
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Impersonal Art existed in the form of landscapes, still-life and decorative designs. Till the late 19th century, art remained more or less representational. The beginning of the 20th century saw art indulging in deliberate distortions in depictions of personalities as well as inanimate objects. Soon afterwards, art saw itself dissociating from representation of real-world objects and personalities.
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This change of conformation reduces RNA polymerase's processivity making the enzyme more prone to dissociating from its DNA-RNA substrate. In this case, termination is not completed by degradation of mRNA but instead is mediated by limiting the elongation efficiency of RNA polymerase and thus increasing the likelihood that the polymerase will dissociate and end its current cycle of transcription.
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Profanity could be used as an affront to authority, a marker of style to establish a rougher identity, as dissociating from communities of practice of the 'goodies' social groups, or as associating with a profanity-using mother. Eckert claims that as hair and dress change across communities of practice, so does language style and use as people seek connections across various linguistic communities.
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In time, emotional exhaustion may set in, leading to distraction, and clear thinking may be difficult or impossible. Emotional detachment, as well as dissociation or "numbing out" can frequently occur. Dissociating from the painful emotion includes numbing all emotion, and the person may seem emotionally flat, preoccupied, distant, or cold. Dissociation includes depersonalisation disorder, dissociative amnesia, dissociative fugue, dissociative identity disorder, etc.
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In higher eukaryotes, TTF-I binds and bends the termination site at the 3' end of the transcribed region. This will force Pol I to pause. TTF-I, with the help of transcript-release factor PTRF and a T-rich region, will induce Pol I into terminating transcription and dissociating from the DNA and the new transcript. Evidence suggests that termination might be rate- limiting in cases of high rRNA production.
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Because an SN1 reaction proceeds with the Substitution of a leaving group with a Nucleophile, the SN designation is used. Because the initial solvolysis step in this reaction involves a single molecule dissociating from its leaving group, the initial stage of this process is considered a uni-molecular reaction. The involvement of only 1 species in the initial phase of the reaction enhances the mechanistic designation to SN1\.
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Viruses rely on hijacking the cellular machinery of the cells they infect to create their own viral proteins and allow them to continue infecting new cells. Their ability to manipulate eIFs like eIF4A1, therefore, considerably impacts their virulence. For instance, cytomegalovirus relies on eIF4A to drive its protein synthesis. The viral protein pUL69 stabilizes the formation of eIF4F, through binding to eIF4A, a process by which eIF4E is prevented from dissociating from the eIF4F complex.
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There are two proposed mechanisms for the activation of PDE. The first proposes that the two inhibitory subunits are differentially bound, sequentially removable and exchangeable between the native complex PDEαβγ2 and PDEαβ. GTP-bound-Tα removes the inhibitory γ subunits one at a time from the αβ catalytic subunits. The second and more likely mechanism states that the GTP-Tα complex binds to the γ subunits but rather than dissociating from the catalytic subunits, it stays with the PDEαβ complex.
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Akin imbroglio is bad news for Republicans Tom Cohen, CNN updated 3:23 PM EDT, Wed August 22, 2012 There were multiple calls from Republicans for Akin to step down as nominee. The Washington Post reported a "stampede" of Republicans dissociating from Akin. NRSC chairman John Cornyn said the Republican Party would no longer provide him Senate election funding. A campaign spokesman for Mitt Romney and Paul Ryan said both disagreed with Akin's position and would not oppose abortion in instances of rape.
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This processivity is also dependent on the presence of the cyclin docking site since increasing the numbers of mutations in this site decreases the net phosphorylation rate. Processive phosphorylation has two plausible mechanisms where a single binding event leads to the phosphorylation of two or more sites. The first mechanism proposes that, without dissociating from the enzyme complex, the primary site is phosphorylated and immediately shifted from the active site to the Cks1 binding pocket to allow for the additional phosphorylation of other CDK sites.
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Interactions are measured in real time, providing the ability to monitor binding specificity, rates of association and dissociation, or concentration, with high precision and accuracy. Only molecules binding to or dissociating from the biosensor can shift the interference pattern and generate a response profile. Unbound molecules, changes in the refractive index of the surrounding medium, or changes in flow rate do not affect the interference pattern. This is a unique characteristic of bio-layer interferometry and extends its capability to perform in crude samples used in applications for protein-protein interactions, quantitation, affinity, and kinetics.
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Lipid-gated ion channels are a class of ion channels whose conductance of ions through the membrane depends directly on lipids. Classically the lipids are membrane resident anionic signaling lipids that bind to the transmembrane domain on the inner leaflet of the plasma membrane with properties of a classic ligand. Other classes of lipid-gated channels include the mechanosensitive ion channels that respond to lipid tension, thickness, and hydrophobic mismatch. A lipid ligand differs from a lipid cofactor in that a ligand derives its function by dissociating from the channel while a cofactor typically derives its function by remaining bound.
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In contrast the Labour party, which had been the largest party in Scotland following the 1929 election (where it had won 42% of the Scottish vote), was relegated into fourth place. Following the election, with Labour appearing to teeter on the edge of the electoral abyss in Scotland, the Independent Labour Party increasingly moved apart from Labour, ultimately dissociating from the party in March 1932. The ILP had dominated the Labour movement in Scotland since 1918, dominating community based activism, and essentially forming the Labour party in Scotland. This had ultimately served to undermine the organizational growth of the Labour party in Scotland.
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In contrast to punk rock, it balances punk's energy and skepticism with art school consciousness, Dadaist experimentalism, and atmospheric, ambient soundscapes. World music, especially African and Asian traditions, was also a major influence. Progressive rock's impact was felt in the work of some post-punk artists, although they tended not to emulate classical rock or Canterbury groups but rather Roxy Music, King Crimson, and krautrock bands, particularly Can. Talking Heads' Jerry Harrison (left) and David Byrne, late 1970s The term "post-progressive" identifies progressive rock that returns to its original principles while dissociating from 1970s prog styles, and may be located after 1978.
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He was among the founders of the Fasci dei lavoratori in Trapani (September 4, 1892) and became its president. He was part of the central committee of the Fasci Siciliani (1893-1894) for the province of Trapani and the regional direction of the newborn Italian Socialist Party (PSI).Clark, Modern Italy, 1871 to the present, p. 124-25 Il «battesimo» del socialismo, La Sicilia, May 24, 2009 Montalto maintained a gradualist and evolutionary vision of political and social struggle, criticizing the revolutionary excesses of the Fasci and dissociating from the radical tendencies advocated by the newspaper Giustizia sociale of Rosario Garibaldi Bosco in Palermo, that broke with Colajanni.
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Their central pore is sufficiently large to admit the DNA strands and some surrounding water molecules, which allows the clamp to slide along the DNA without dissociating from it and without loosening the protein-protein interactions that maintain the toroid shape. When associated with a DNA clamp, DNA polymerase is dramatically more processive; without the clamp most polymerases have a processivity of only about 100 nucleotides. The interactions between the polymerase and the clamp are more persistent than those between the polymerase and the DNA. Thus, when the polymerase dissociates from the DNA, it is still bound to the clamp and can rapidly reassociate with the DNA.
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EF-G in pathogenic bacteria can be inhibited by antibiotics that prevent EF-G from binding to the ribosome, carrying out translocation or dissociating from the ribosome. For example, the antibiotic thiostrepton prevents EF-G from binding stably to the ribosome, while the antibiotics dityromycin and GE82832 inhibit the activity of EF-G by preventing the translocation of the A site tRNA. Dityromycin and GE82832 do not affect the binding of EF-G to the ribosome, however. The antibiotic fusidic acid is known to inhibit Staphylococcus aureus and other bacteria by binding to EF-G after one translocation event on the ribosome, preventing EF-G from dissociating.
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As a long-lasting in vivo effect, cofilin recycles older ADP-F-actin, helping cell to maintain ATP-G-actin pool for sustained motility. pH, phosphorylation and phosphoinositides regulate cofilin's binding and associating activity with actin The Arp2/3 complex and cofilin work together to reorganize the actin filaments in the cytoskeleton. Arp 2/3, an actin binding proteins complex, binds to the side of ATP-F-actin near the growing barbed end of the filament, causing nucleation of a new F-actin branch, while cofilin-driven depolymerization takes place after dissociating from the Arp2/3 complex. They also work together to reorganize actin filaments in order to traffic more proteins by vesicle to continue the growth of filaments.
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Cryo-EM structure of the DNA-bound PolD–PCNA processive complex Structural basis for DNA binding by the PolD–PCNA complex A DNA clamp, also known as a sliding clamp or β-clamp, is a protein complex that serves as a processivity- promoting factor in DNA replication. As a critical component of the DNA polymerase III holoenzyme, the clamp protein binds DNA polymerase and prevents this enzyme from dissociating from the template DNA strand. The clamp- polymerase protein–protein interactions are stronger and more specific than the direct interactions between the polymerase and the template DNA strand; because one of the rate-limiting steps in the DNA synthesis reaction is the association of the polymerase with the DNA template, the presence of the sliding clamp dramatically increases the number of nucleotides that the polymerase can add to the growing strand per association event. The presence of the DNA clamp can increase the rate of DNA synthesis up to 1,000-fold compared with a nonprocessive polymerase.
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Michele Marie Desmarais (2008), Changing Minds : Mind, Consciousness And Identity In Patañjali's Yoga-Sutra, Motilal Banarsidass, , page 132-136 This is seen as a means to begin the process of dissociating from external world, connecting with one's inner world, focusing and getting one-minded in Yoga.See Yogasutra I.28 and I.29; Whicher states that Patañjali's concept of Īśvara is neither a creator God nor the universal Absolute of Advaita Vedanta school of Hinduism. Whicher also notes that some theistic sub-schools of Vedanta philosophy of Hinduism, inspired by the Yoga school, prefer to explain the term Īśvara as the "Supreme Being that rules over the cosmos and the individuated beings". However, in the Yoga Sūtras of Patañjali, and extensive literature of Yoga school of Hinduism, Īśvara is not a Supreme Ruler, Īśvara is not an ontological concept, rather it has been an abstract concept to meet the pedagogical needs for human beings accepting Yoga philosophy as a way of life.
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Catch-slip transition allows leukocytes to roll along blood vessel walls. Researchers have hypothesized that the ability of leukocytes to maintain attachment and rolling on the blood vessel wall can be explained by a combination of many factors, including cell flattening to maintain a larger binding surface-area and reduce hydrodynamic drag, as well as tethers holding the rear of the rolling cell to the endothelium breaking and slinging to the front of the rolling cell to reattach to the endothelial wall. These hypotheses work well with Marshall’s 2003 findings that selectin bonds go through a catch-slip transition in which initial increases in shear force strengthen the bond, but with enough applied force bond lifetimes begin to decay exponentially. Therefore, the weak binding of a sling at the leading edge of a rolling leukocyte would initially be strengthened as the cell rolls farther and the tension on the bond increases, preventing the cell from dissociating from the endothelial wall and floating freely in the bloodstream despite high shear forces.
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IRAK-1 forms a complex with STAT3 and the IL-10 promoter element in the nucleus and is required for STAT3 phosphorylation and activation of IL-10 transcription. IRAK-2 plays an important role in TLR-mediated NF-κB activation. Knocking down IRAK-2 has been shown to impair NF-κB activation by TLR3, TLR4 and TLR8. The mechanism of how IRAK-2 functions is still unknown, however, IRAK-2 has been shown to interact with a TIR adaptor protein that does not bind to IRAK-1, called Mal/TIRAP. Mal/TIRAP has been specifically implicated in TLR2 and TLR4 mediated NF-κB signaling. In addition, it has been shown that IRAK-2 is recruited to the TLR3 receptor. IRAK-2 is the only IRAK family member that is known to play a role in TLR3 signaling. One of the most distinct features of IRAK-M is that it is a negative regulator of TLR signaling to prevent excessive inflammation. It is thought that IRAK-M enhances the binding of MyD88 to IRAK-1 and IRAK-4, preventing IRAK-1 from dissociating from the receptor complex and inducing downstream NF-κB and MAPK signaling.
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