80 Sentences With "congenital malformation"

How to use congenital malformation in a sentence? Find typical usage patterns (collocations)/phrases/context for "congenital malformation" and check conjugation/comparative form for "congenital malformation". Mastering all the usages of "congenital malformation" from sentence examples published by news publications.

Babies of normal-weight mothers had a 3.4% risk of a major congenital malformation, the researchers calculated.
But, she added, "we only looked at congenital malformation, not other possible negative outcomes for women and their children."
She previously underwent a successful heart surgery at just 2 months old, when doctors corrected a congenital malformation of a valve.
She previously underwent a successful heart surgery at just two-months-old, when doctors corrected a congenital malformation of a valve.
Operating on a young dog with a congenital malformation may delay the development of arthritis though not necessarily prevent it indefinitely.
A total of 220,2400 of the infants -- 2600% -- had a major congenital malformation, the researchers found when looking at the medical records.
When a baby is born with a potentially life-limiting condition such as extreme prematurity or a congenital malformation, we help their parents navigate decision-making.
Just this month, the first "Zika baby" born in the continental U.S., at a Hackensack, N.J., hospital, was diagnosed with a congenital malformation of the head.
In addition, the rates of preterm birth, cesarean delivery, low birth weight, poor fetal growth, or a congenital malformation at delivery were greater among women with asthma.
Looking at 13 million pregnancies in the United States, they found that 35 infants per 1,000 were diagnosed with some form of congenital malformation, when the women did not take stimulants during pregnancy.
"These findings suggest that the use of antipsychotics during the first trimester does not seem to increase congenital malformation," or birth defects, said the lead author, Krista F. Huybrechts, an assistant professor of medicine at Harvard.
They also had a 14 percent increased risk for having a low birth weight baby, a 14 percent increased risk for preterm birth, and a 21 percent increased risk for having a baby with a congenital malformation.
Apparently related to the problem of declining semen quality is an increase in testicular cancer in many countries; in undescended testicles; and in a congenital malformation of the penis called hypospadias (in which the urethra exits the side or base of the penis instead of the tip).
As a congenital malformation or ectopia, it is distinctly different from the trauma or iatrogenic development of an encephalocele.
Cenani–Lenz syndactylism, also known as Cenani–Lenz syndrome or Cenani–syndactylism, is an autosomal recessive congenital malformation syndrome involving both upper and lower extremities.
The acute mortality associated with the Senning procedure is reported to be around 5-10%. Patient selection and complexity of the congenital malformation are determinants of mortality risk.
EEM syndrome (or Ectodermal dysplasia, Ectrodactyly and Macular dystrophy syndrome) is an autosomal recessive congenital malformation disorder affecting tissues associated with the ectoderm (skin, hair, nails, teeth), and also the hands, feet and eyes.
NYEE performs elective cosmetic surgery, reconstructive surgery following trauma or disease, and congenital malformation surgery. In 2018, its services expanded to include Gender Affirmation surgery in collaboration with Mount Sinai’s Center for Transgender Medicine and Surgery.
Nelson was mentioned as a possible successor to Democratic U.S. Senator Tim Johnson, who suffered stroke-like bleeding in the brain caused by a congenital malformation known as arteriovenous malformation. Instead, former Governor Mike Rounds was elected.
Church WS. Congenital malformation of heart: abnormal septum in left auricle. Trans Path Soz. 1868;19:188-190. Griffith TW. Note on a Second Example of Division of the Cavity of the Left Auricle into Two Compartments by a Fibrous Band. J Anat Physiol.
Intestinal atresia is any congenital malformation of the structure of the intestine that causes bowel obstruction. The malformation can be a narrowing (stenosis), absence or malrotation of a portion of the intestine. These defects can either occur in the small or large intestine.
Congenital umbilical hernia is a congenital malformation of the navel (umbilicus). Among adults, it is three times more common in women than in men; among children, the ratio is roughly equal. It is also found to be more common in children of African descent.
It went on to become one of the most popular and commercially successful films the NFB ever made. In 1987, Klein suffered a catastrophic stroke caused by a congenital malformation in her brainstem. She became locked-in, quadriplegic, respirator-dependent, and experienced panic attacks.
Superficial lymphatic malformation is a congenital malformation of the superficial lymphatics, presenting as groups of deep-seated, vesicle-like papules resembling frog spawn, at birth or shortly thereafter.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders.
With a rate from 12.5% to 17.5% (Dawson-Falk et al., 1992), bicuspid aortic valve is the most common congenital malformation affecting the heart in this syndrome. It is usually isolated, but it may be seen in combination with other anomalies, particularly coarctation of the aorta.
Aphallia is a congenital malformation in which the phallus (penis or clitoris) is absent. It is the female counterpart of penile agenesis and testicular agenesis. The word is derived from the Greek a- for "not", and phallos for "penis". It is classified as an intersex condition.
Stanislas Lyonnet is a French geneticist. As of 2012 he was Professor of genetics at Paris Descartes University, and a clinical geneticist in the Department of Medical Genetics at the Hôpital Necker - Enfants Malades. His research is aimed at isolating the genes that cause congenital malformation and birth defects.
The liver and lungs are also at higher risk for abnormalities. Cloverleaf skull, a congenital malformation in which the skull has three lobes, the brain is deformed, and hydrocephalus occurs, is also associated with PCE.Aronson 2008, p. 520 Like birth defects, small head size, and stroke are risks in PCE.
Harry Eastlack was born on November 17, 1933 at 10:24 AM in the Woman's Hospital of Philadelphia. There are no reports of any difficulties during his delivery, though there was the observation of a minor congenital malformation. The noted malformation was his congenital bilateral hallux valgus, oftentimes referred to as a bunion.
Pachygyria (from the Greek "pachy" meaning "thick" or "fat" gyri) is a congenital malformation of the cerebral hemisphere. It results in unusually thick convolutions of the cerebral cortex. Typically, children have developmental delay and seizures, the onset and severity depending on the severity of the cortical malformation. Infantile spasms are common in affected children, as is intractable epilepsy.
Pancreaticobiliary maljunction is a congenital malformation, in which the pancreatic and bile ducts join anatomically outside the duodenal wall, forming a markedly long common channel. This anomaly prevents normal control by the sphincter of Oddi located in the duodenal wall, allowing regurgitation of pancreatic juices into the biliary tract and possibly leading to a higher probability of pancreaticobiliary cancers.
Biopsy of the small intestine shows dilation of the lacteals of the villi and distension of the lymphatic vessels. Reduced lymph flow leads to a malabsorption syndrome of the small intestine, especially of fat and fat- soluble vitamins. Rupture of the lymphatics causes protein loss into the intestines. The most common cause of lymphangiectasia was congenital malformation of the lymphatics.
Ectopia cordis (Greek: "away / out of place" + Latin: "heart") or ectopic heart is a congenital malformation in which the heart is abnormally located either partially or totally outside of the thorax. The ectopic heart can be found along a spectrum of anatomical locations, including the neck, chest, or abdomen. In most cases, the heart protrudes outside the chest through a split sternum.
Triphalangeal thumb (TPT) is a congenital malformation where the thumb has three phalanges instead of two. The extra phalangeal bone can vary in size from that of a small pebble to a size comparable to the phalanges in non-thumb digits. The true incidence of the condition is unknown, but is estimated at 1:25,000 live births.Lapidus PW, Guidotti FP, Coletti CJ, Triphalageal thumb.
A preauricular sinus is a common congenital malformation characterized by a nodule, dent or dimple located anywhere adjacent to the external ear. Frequency of preauricular sinus differs depending the population: 0.1–0.9% in the US, 0.9% in the UK, and 4–10% in Asia and parts of Africa. Preauricular sinuses are inherited features, and most often appear unilaterally. They are present bilaterally in 25–50% of cases.
It is the most important daily work at SACPER, and is expressed through a solidary campaign against congenital malformation, which operates throughout the country as a SACPER contribution to the community. It is dedicated to the medical and surgical treatment of patients with cleft lip and palate with the participation of voluntary and pro bono plastic surgeons, and is directed by Dr. Rodolfo Rojas.
Since the precursors of all the major organs are created by this time, the fetal period is described both by organ and by a list of changes by weeks of gestational age. Because the precursors of the organs are now formed, the fetus is not as sensitive to damage from environmental exposure as the embryo was. Instead, toxic exposure often causes physiological abnormalities or minor congenital malformation.
Bronchopulmonary sequestration (BPS) is a rare congenital malformation of the lower respiratory tract. It consists of a nonfunctioning mass of normal lung tissue that lacks normal communication with the tracheobronchial tree, and that receives its arterial blood supply from the systemic circulation. BPS is estimated to comprise one to six percent of all congenital pulmonary malformations, making it an extremely rare disorder. Sequestrations are classified anatomically.
Hazardous drugs expose health care workers to serious health risks. Many studies show that antineoplastic drugs could have many side effects on the reproductive system, such as fetal loss, congenital malformation, and infertility. Health care workers who are exposed to antineoplastic drugs on many occasions have adverse reproductive outcomes such as spontaneous abortions, stillbirths, and congenital malformations. Moreover, studies have shown that exposure to these drugs leads to menstrual cycle irregularities.
There is the potential for an indirect inguinal hernia to develop, although not all people with a patent vaginal process will develop one. The more patent the vaginal process, the more likely the patient is to develop a hernia. Congenital malformation of the vaginal process is also the leading cause of testicular torsion, since lack of attachment to the inner lining of the scrotum leaves the testicles free to twist.
Despite the similarity of name, an epispadias is not a type of hypospadias, and involves a problem with a different set of embryologic processes. Women can also have this type of congenital malformation. Epispadias of the female may occur when the urethra develops too far anteriorly, exiting in the clitoris or even more forward. For females, this may not cause difficulty in urination but may cause problems with sexual satisfaction.
The Dandy–Walker malformation is a congenital malformation associated with hydrocephalus. In 1921 Dandy reported a case of hydrocephalus caused by obstruction of outflow of CSF from the fourth ventricle. In 1944 A. Earl Walker (who eventually became chairman of neurosurgery at Johns Hopkins) described a similar case of congenital closure of the outflow of the fourth ventricle. This congenital anomaly became known as the Dandy-Walker cyst.
Other common causes include trauma, autoimmune disease, high blood calcium, hypothermia, and endoscopic retrograde cholangiopancreatography (ERCP). Pancreas divisum is a common congenital malformation of the pancreas that may underlie some recurrent cases. Diabetes mellitus type 2 is associated with a 2.8-fold higher risk. Less common causes include pancreatic cancer, pancreatic duct stones, on vasculitis (inflammation of the small blood vessels in the pancreas), and porphyria—particularly acute intermittent porphyria and erythropoietic protoporphyria.
Most conditions associated with the great cerebral vein are due to congenital defects. Vein of Galen aneurysmal malformations (VGAM) are the most common form of symptomatic cerebrovascular malformation in neonates and infants. The presence and locations of angiomas are very variable and do not follow any predictable pattern. The congenital malformation develops during weeks 6-11 of fetal development as a persistent embryonic prosencephalic vein of Markowski; thus, VGAM is actually a misnomer.
Pulmonary hypoplasia is incomplete development of the lungs, resulting in an abnormally low number or size of bronchopulmonary segments or alveoli. A congenital malformation, it most often occurs secondary to other fetal abnormalities that interfere with normal development of the lungs. Primary (idiopathic) pulmonary hypoplasia is rare and usually not associated with other maternal or fetal abnormalities. Incidence of pulmonary hypoplasia ranges from 9–11 per 10,000 live births and 14 per 10,000 births.
Müllerian anomalies can be part of a multiple malformation syndrome. Mullerian anomalies occur as a congenital malformation of the mullerian ducts during embryogenesis. The mullerian ducts are also referred to as paramesonephric ducts, referring to ducts next to (para) the mesonephric (Wolffian) duct during foetal development. Paramesonephric ducts are paired ducts derived from the embryo, and for females develop into the uterus, uterine tubes, cervix and upper two-thirds of the vagina.
A preureteric vena cava, also known as a retrocaval ureter, is a rare congenital malformation of the right human ureter, in which the ureter passes behind the inferior vena cava, causing compression possibly leading to hydronephrosis. The prevalence of this condition is approximately 1 per 1,000 persons, with males 2-3 times more likely than females to develop the condition. Symptoms often do not manifest until those with the condition are aged in their 20s or 30s.
The project was later tested with a group at the Rotschild hospital in Haifa, Dutch Hospitals in the Netherlands. It was extended to other fields of endoctinology, to Congenital malformation, and to heart related issues. Due to collaborative projects such as these, the Scientific Center quickly became recognized as a focal point for research and development in engineering and scientific computing for IBM's European Scientific Centers. This facilitated the growth of the Center from fifteen to twenty-two employees.
Septo-optic dysplasia (SOD), previously known as de Morsier syndrome, is a rare congenital malformation syndrome featuring underdevelopment of the optic nerve, pituitary gland dysfunction, and absence of the septum pellucidum (a midline part of the brain). Two of these features need to be present for a clinical diagnosis — only 30% of patients have all three. French doctor Georges de Morsier first recognized the relation of a rudimentary or absent septum pellucidum with hypoplasia of the optic nerves and chiasm in 1956.
Similarly, if the voice pathology remained stable or varied significantly regardless of context, it is likely unrelated to vocal effort and suggestive of a congenital malformation of the vocal structure. The interview process also includes the collection of a thorough history which informs the clinician of potential risk factors affecting the child (i.e. prematurity, NICU stay, family history, ENT surgeries, hearing impairment etc.). In these instances the clinician should screen for swallowing, pneumologic and digestive impairments which could be contributing to the dysphonia.
In particular, Multiple sclerosis has been suggested as being neurocristopathic in origin. The usefulness of the definition resides in its ability to refer to a potentially common etiological factor for certain neoplasms and/or congenital malformation associations that are otherwise difficult to group with other means of nosology. Moreover, the classification of NCP is intended to help physicians understand the causal mechanism that drives the formation of a certain NCP, and therefore the selection of the correct diagnostic test and therapies.
Tuber cinereum hamartoma is a benign tumor in which a disorganized collection of neurons and glia accumulate at the tuber cinereum of the hypothalamus on the floor of the third ventricle. It is a congenital malformation, included on the spectrum of gray matter heterotopias. Formation occurs during embryogenesis, typically between days 33 and 41 of gestation. Size of the tumor varies from one to three centimeters in diameter, with the mean being closer to the low end of this range.
Abdominal wall defects are common in newborns with BWS and may require surgical treatment. These defects can range in severity from omphalocele (most serious) to umbilical hernia and diastasis recti (least serious). An omphalocele is a congenital malformation in which a newborn's intestines, and sometimes other abdominal organs, protrude out of the abdomen through the umbilicus. Newborns with an omphalocele typically require surgery to place the abdominal contents back into the abdomen in order to prevent serious infection or shock.
Thomas et al. (1986) also emphasized the occurrence of the cryptophthalmos syndrome without cryptophthalmos and proposed diagnostic criteria for Fraser syndrome. Major criteria consisted of cryptophthalmos, syndactyly, abnormal genitalia, and positive family history. Minor criteria were congenital malformation of the nose, ears, or larynx, cleft lip and/or palate, skeletal defects, umbilical hernia, renal agenesis, and mental retardation. Diagnosis was based on the presence of at least 2 major and 1 minor criteria, or 1 major and 4 minor criteria.
However, these results may principally reflect village endogamy rather than consanguinity per se. Endogamy is marrying within a group and in this case the group was a village. The marital patterns of the Amish are also an example of endogamy.Bittles and Black, 2009, Section 6 The Latin American Collaborative Study of Congenital Malformation found an association between consanguinity and hydrocephalus, postaxial polydactyly, and bilateral oral and facial clefts. Another picture emerges from the large literature on congenital heart defects, which are conservatively estimated to have an incidence of 50/1,000 live births.
The most extensive epidemiological survey on this congenital malformation has been carried out by Dharmasena et al. and using English National Hospital Episode Statistics, they calculated the annual incidence of anophthalmia, microphthalmia and congenital malformations of orbit/lacrimal apparatus from 1999 to 2011. According to this study the incidence of congenital anophthalmia ranged from 2.4 (95% CI 1.3 to 4.0) per 100 000 infants in 1999 to 0.4 (0 to 1.3) in 2011. Parents that already have a child who suffers from anophthalmia has a 1 in 8 chance of having another child with anophthalmia.
Cardiac diverticulum or ventricular diverticulum is defined as a congenital malformation of the fibrous or muscular part of the heart which is only visible during chest x-rays or during an echocardiogram reading . This should not be confused with ventricular diverticulum, as the latter is a sub type derived from the latter in congenital cases. it is usually asymptomatic and is only detected using imaging. Fibrous diverticulum is characterised by a calcification if present at the tip ( apex) or a thrombi that may detaches to form an emboli.
In a genome-wide association study (GWAS) meta-analysis conducted across European and African American populations, the NDUFAB1 gene and two other genes (MFAP3L and PALB2) were identified as genetic loci significantly associated with anxiety disorders (ADs). Since the comorbidity of ADs arises from their shared genetic basis, these candidate genetic loci may become therapeutic targets for AD treatments. Moreover, a study to identify small molecule drug targets for Tetralogy of Fallot (TOF), a congenital malformation of the heart, found the NDUFAB1 gene to be a major hub gene of differentially expressed genes in TOF.
Ho–Kaufman–Mcalister syndrome, is a rare congenital malformation syndrome where infants are born with a cleft palate, micrognathia, Wormian bones, congenital heart disease, dislocated hips, bowed fibulae, preaxial polydactyly of the feet, abnormal skin patterns, and most prominently, missing tibia. The etiology is unknown. Ho–Kaufman–Mcalister syndrome is named after Chen-Kung Ho, R.L. Kaufman, and W.H. Mcalister who first described the syndrome in 1975 at Washington University in St. Louis. It is considered a rare disease by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
Ambroise Paré In 1579, Ambroise Paré made the first description of diaphragmatic rupture, in a French artillery captain who had been shot eight months before his death from complications of the rupture. Using autopsies, Paré also described diaphragmatic rupture in people who had suffered blunt and penetrating trauma. Reports of diaphragmatic herniation due to injury date back at least as far as the 17th century. Petit was the first to establish the difference between acquired and congenital diaphragmatic hernia, which results from a congenital malformation of the diaphragm.
While the level of evident maternal infection may be minimal, the consequences for the fetus are serious before day 85 of gestation. After day 85, the lamb is most likely to be born normal with antibodies to the virus, given the state of the fetal immune system at this stage in gestation. Fetal infection manifests as four syndromes: # Early embryonic mortality # Abortion and stillbirth # Congenital malformation # Birth of small weak lambs with immunosuppression The animals that do survive to live birth will frequently show the 'hairy shaker' signs. The virus gathers in fetal lymphoid tissue, hair follicles, and the central nervous system.
The lateral body wall folds, pulling the amnion in with it so that the amnion surrounds the embryo and extends over the connecting stalk, which becomes the umbilical cord, which connects the fetus with the placenta. If the ventral body wall fails to close, ventral body wall defects can result, such as ectopia cordis, a congenital malformation in which the heart is abnormally located outside the thorax. Another defect is gastroschisis, a congenital defect in the anterior abdominal wall through which the abdominal contents freely protrude. Another possibility is bladder exstrophy, in which part of the urinary bladder is present outside the body.
Frontonasal dysplasia (FND) is a congenital malformation of the midface. For the diagnosis of FND, a patient should present at least two of the following characteristics: hypertelorism (an increased distance between the eyes), a wide nasal root, vertical midline cleft of the nose and/or upper lip, cleft of the wings of the nose, malformed nasal tip, encephalocele (an opening of the skull with protrusion of the brain) or V-shaped hair pattern on the forehead. The cause of FND remains unknown. FND seems to be sporadic (random) and multiple environmental factors are suggested as possible causes for the syndrome.
The lateral body wall folds, pulling the amnion in with it so that the amnion surrounds the embryo and extends over the connecting stalk, which becomes the umbilical cord, which connects the fetus with the placenta. If the ventral body wall fails to close, ventral body wall defects can result, such as ectopia cordis, a congenital malformation in which the heart is abnormally located outside the thorax. Another defect is gastroschisis, a congenital defect in the anterior abdominal wall through which the abdominal contents freely protrude. Another possibility is bladder exstrophy, in which part of the urinary bladder is present outside the body.
The second is a congenital malformation of the stapes. In both of these situations, it is possible to improve hearing by removing the stapes bone and replacing it with a micro prosthesis - a stapedectomy, or creating a small hole in the fixed stapes footplate and inserting a tiny, piston-like prosthesis - a stapedotomy. The results of this surgery are generally most reliable in patients whose stapes has lost mobility because of otosclerosis. Nine out of ten patients who undergo the procedure will come out with significantly improved hearing while less than 1% will experience worsened hearing acuity or deafness.
In the United States, more than 6.5 million bone defects and more than 3 million facial injury cases have been reported each year. More than 2.2 million bone graft procedures are performed worldwide per year. The common causes for bone graft are tumor resection, congenital malformation, trauma, fractures, surgery, osteoporosis, and arthritis. According to the National Ambulatory Medical Care Survey (NAMCS), in 2010, there were approximately 63 million visits to the orthopedic surgery department and about 3.5 million visits for fractures in the emergency departments in the U.S. Among the 6.5 million bone fracture or defect cases, approximately 887,679 people were hospitalized.
According to physicians, the tail Oram has is not a real tail, but a congenital malformation known as spina bifida, in this case of the rare meningocele category. It is possible for human embryos to develop a real tail, as the genes which cause it still exist in many people. However, the probability of this gene expressing is very low: it can happen because of rare recessive gene coupling, or some form of mutation that brings the gene back to a dominant place. That is why very few cases have been recorded in the history of medicine.
Pulmonary atresia is a congenital malformation of the pulmonary valve in which the valve orifice fails to develop. The valve is completely closed thereby obstructing the outflow of blood from the heart to the lungs. The pulmonary valve is located on the right side of the heart between the right ventricle and pulmonary artery. In a normal functioning heart, the opening to the pulmonary valve has three flaps that open and close In congenital heart defects such as pulmonary atresia, structural abnormalities can include the valves of the heart, and the walls and arteries/veins near the heart muscle.
Gideon Koren, Nathalie Carey, Robert Gagnon, et al. Cancer Chemotherapy and Pregnancy, "Journal of Obstetrics and Gynecology Canada", March 2013 Two cases of cerebral ventriculomegaly observed in the study were documented prior to the administration of chemotherapy, suggesting an alternate cause of congenital malformation. The third case involved pyloric stenosis in an infant whose mother received a combination regimen of docetaxel, doxorubicin, cyclophosphamide and paclitaxel; because the fetus was exposed to multiple drugs in utero, it remains difficult to identify docetaxel as the causative teratogenic agent. Further studies are needed to better assess the safety of docetaxel in pregnancy and determine appropriate dosing in pregnant women.
Sun Hudson: On March 15, 2005, six-month-old infant Sun Hudson, who had a lethal congenital malformation, was one of the first children to have care withdrawn under the Texas Futile Treatment Law. Doctors demonstrated in the ethics committee reviews that keeping the infant on a respirator would only delay his inevitable death. Tirhas Habtegiris: In December 2005, Tirhas Habtegiris, a young woman and legal immigrant from Eritrea, was removed from a respirator. Habtegiris died from complications of incurable and untreatable cancer that had spread to her lungs. Andrea Clark: In April 2006, relatives of 53-year-old Andrea Clark were given the 10-day notice under this act.
An infant being immunized in Bangladesh Infant mortality is the death of an infant in the first year of life, often expressed as the number of deaths per 1000 live births (infant mortality rate). Major causes of infant mortality include dehydration, infection, congenital malformation and SIDS. This epidemiological indicator is recognized as a very important measure of the level of health care in a country because it is directly linked with the health status of infants, children, and pregnant women as well as access to medical care, socioeconomic conditions, and public health practices. There is a positive relationship between national wealth and good health.
Cerebellar development occurs during late embryogenesis and the early postnatal period, with CGNP proliferation in the EGL peaking during early development (postnatal day 7 in the mouse). As CGNPs terminally differentiate into cerebellar granule cells (also called cerebellar granule neurons, CGNs), they migrate to the internal granule layer (IGL), forming the mature cerebellum (by post-natal day 20 in the mouse). Mutations that abnormally activate Sonic hedgehog signaling predispose to cancer of the cerebellum (medulloblastoma) in humans with Gorlin Syndrome and in genetically engineered mouse models. Congenital malformation or underdevelopment (hypoplasia) of the cerebellar vermis is a characteristic of both Dandy–Walker syndrome and Joubert syndrome.
Intra-operative gross photograph of the spleen attached to the left testis in a 1-year old boy with splenogonadal fusion Splenogonadal fusion is a rare congenital malformation that results from an abnormal connection between the primitive spleen and gonad during gestation. A portion of the splenic tissue then descends with the gonad. Splenogonadal fusion has been classified into two types: continuous, where there remains a connection between the main spleen and gonad; and discontinuous, where ectopic splenic tissue is attached to the gonad, but there is no connection to the orthotopic spleen. Patients with continuous splenogonadal fusion frequently have additional congenital abnormalities, most commonly cryptorchidism.
At last, ashamed of misappropriating Casaubon's stores of learning, they asked him to refute the popular Annals of Baronius. In 1614 he published De rebus sacris et ecclesiasticis exercitationes XVI which consisted of a philological analysis of Corpus Hermeticum, a series of neo-platonic texts. He placed their origin in the third or fourth century AD, rather than in a much earlier "hermetic" period to which they had generally been ascribed. He died in London of a congenital malformation of the bladder; but his end was hastened by an unhealthy life of over-study, and by his anxiety to acquit himself creditably in his criticism on Baronius.
Oxalic acid in concentrated form can have harmful effects through contact and if ingested. It is not identified as mutagenic or carcinogenic, although there is a study suggesting it might cause breast cancer; there is a possible risk of congenital malformation in the fetus; may be harmful if inhaled, and is extremely destructive to tissue of mucous membranes and upper respiratory tract; harmful if swallowed; harmful to and destructive of tissue and causes burns if absorbed through the skin or is in contact with the eyes. Symptoms and effects include a burning sensation, cough, wheezing, laryngitis, shortness of breath, spasm, inflammation and edema of the larynx, inflammation and edema of the bronchi, pneumonitis, pulmonary edema.Oxalic acid dihydrate. MSDS. sigmaaldrich.
Ultrasound image of the fetal head at 19 weeks of pregnancy in a modified axial section, showing the normal fetal cerebellum and cisterna magna Congenital malformation, hereditary disorders, and acquired conditions can affect cerebellar structure and, consequently, cerebellar function. Unless the causative condition is reversible, the only possible treatment is to help people live with their problems. Visualization of the fetal cerebellum by ultrasound scan at 18 to 20 weeks of pregnancy can be used to screen for fetal neural tube defects with a sensitivity rate of up to 99%. In normal development, endogenous sonic hedgehog signaling stimulates rapid proliferation of cerebellar granule neuron progenitors (CGNPs) in the external granule layer (EGL).
It is usually considered a congenital malformation of unknown cause. Since at an early stage of fetal development the penis is curved downward, it has been proposed that chordee results from an arrest of penile development at that stage. The curvature of a chordee can involve #tethering of the skin with urethra and corpora of normal size; #curvature induced by fibrosis and contracture of the fascial tissue (Buck's fascia or dartos) surrounding the urethra; #disproportionately large corpora in relation to the urethral length without other demonstrable abnormality of either; or #a short, fibrotic urethra that tethers the penis downward (the least common type). Severe degrees of chordee are usually associated with hypospadias, but mild degrees of curvature may occur in many otherwise normal males.
Müllerian agenesis, also known as Mayer–Rokitansky–Küster–Hauser syndrome (MRKH) or vaginal agenesis, is a congenital malformation characterized by a failure of the Müllerian duct to develop, resulting in a missing uterus and variable degrees of vaginal hypoplasia of its upper portion. Müllerian agenesis (including absence of the uterus, cervix and/or vagina) is the cause in 15% of cases of primary amenorrhoea. Because most of the vagina does not develop from the Müllerian duct, instead developing from the urogenital sinus, along with the bladder and urethra, it is present even when the Müllerian duct is completely absent. Because ovaries do not develop from the Müllerian ducts, affected people might have normal secondary sexual characteristics but are infertile due to the lack of a functional uterus.
Cafe au lait spots As the cases reported are few in number, and the phenotype expression for ring chromosome 15 syndrome occurs over a wider spectrum; the cells of patients could have different levels of mosaicism. Ring chromosome 15 is associated with growth delay due to insulin-like growth factor I resistance. Common features include growth delay, mental retardation and congenital malformation. Of 25 studies examined by Butler MG, all cases reported growth deficiency, 95% of cases showed varied levels of mental retardation, and 88% of the patients showed microcephaly. Besides those top 3 symptoms that are found most frequently, other symptoms include: Delayed bone age (7%), Hypertelorism (46%), Brachydactyly (44%), Triangular face (42%), Speech delay (39%),Frontal bossing (36%), Anomalous ear (30%), Café-au-lait spots (30%), Cryptorchidism (30%) and Cardiac abnormalities (30%).
Spitzka came to the conclusion that Guiteau had "the insane manner" he had so often observed in asylums, adding that Guiteau was a "morbid egotist" with "a tendency to misinterpret the real affairs of life". He thought the condition to be the result of "a congenital malformation of the brain". George Corkhill, who was the District of Columbia's district attorney and on the prosecuting team, summed up the prosecution's opinion of Guiteau's insanity defense in a pre-trial press statement that also mirrored public opinion on the issue. A cartoon depicting Guiteau as a dangerous fool Guiteau became something of a media sensation during his entire trial for his bizarre behavior, which included his frequently cursing and insulting the judge, most of the witnesses, the prosecution, and even his defense team, as well as formatting his testimony in epic poems which he recited at length, and soliciting legal advice from random spectators in the audience via passed notes.

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