Additionally, 97 of the instances included records of maternal complications or at least one congenital anomaly.
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From hundreds of miles away he showed colleagues how to negotiate a blast injury and operate on a congenital anomaly affecting the hand.
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Camden was diagnosed with Amelia-phocomelia syndrome, a rare congenital anomaly that causes parts of the skeleton not to grow, soon after he was born.
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At the time, Brown Brush's unborn baby was diagnosed with oligodactyly, a congenital anomaly defined as the presence of fewer than five fingers on a hand.
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Their rhetoric is carefully calculated to put abortion proponents in the position of having to defend the seemingly indefensible: choosing to end a pregnancy because of a congenital anomaly.
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In an exclusive interview with PEOPLE for this week's issue, out Friday, the 23-year-old Sister Wives star recalls feeling "so much guilt" upon finding out during a routine ultrasound that her daughter, now 9 weeks, had oligodactyly, a congenital anomaly defined as the presence of fewer than five fingers on a hand.
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Fleischer's syndrome is an extremely rare congenital anomaly characterized by displacement of the nipples, occasional polymastia, and hypoplasia of both kidneys.
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Fryns syndrome is an autosomal recessive multiple congenital anomaly syndrome that is usually lethal in the neonatal period. Fryns (1987) reviewed the syndrome.
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All 6 children are leading normal healthy lives. He is also the first Indian surgeon to have successfully operated on a rare congenital anomaly of duplication of stomodeum (double mouth) in December, 1995.
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Congenital stenosis of vena cava is a congenital anomaly in which the superior vena cava or inferior vena cava has an aberrant interruption or coarctation. In some cases, it can be asymptomatic, and in other cases it can lead to fluid accumulation and cardiopulmonary collapse.
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Paramethadione is associated with various adverse effects including sedation, increased visual sensitivity to light, GI distress, edema, nephropathy, neutropenia, myasthenia gravis-like syndrome, fatal aplastic anemia, and severe birth defects known as fetal trimethadione syndrome (or paramethadione syndrome).Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007.
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New Directions in Human Genetics: A Symposium. New York: The National Foundation—March of Dimes, p. 72. In 1960 he first reported the extra chromosome in trisomy 13.K. Patau, D. W. Smith, E. Therman, S. L. Inhorn, H. P. Wagner: Multiple congenital anomaly caused by an extra autosome.
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Benjamin Syndrome is a type of multiple congenital anomaly/intellectual disability (MCA/MR) syndrome. It is characterized by hypochromic anemia with intellectual disability and various craniofacial and other anomalies. It can also include heart murmur, dental caries and splenic tumors. It was first described in the medical literature in 1911.
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Blepharophimosis is a congenital anomaly in which the eyelids are underdeveloped such that they cannot open as far as usual and permanently cover part of the eyes. Both the vertical and horizontal palpebral fissures (eyelid openings) are shortened; the eyes also appear spaced more widely apart as a result, known as telecanthus.
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Symmastia is a condition defined as a confluence of the breast tissue of both breasts across the intermammary cleft that normally divides them. It can be surgically corrected by a plastic surgeon through symmastia revision. Symmastia can either be a congenital anomaly or iatrogenic. Congenital symmastia is a rare condition with few published cases.
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Diplopodia is a congenital anomaly in tetrapods that involves duplication of elements of the foot on the hind limb. It comes from the Greek roots diplo = "double" and pod = "foot". Diplopodia is often found in conjunction with other structural abnormalities and can be lethal. It is more extreme than polydactyly, the presence of extra digits.
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Symmastia is a condition defined as a confluence of the breast tissue of both breasts across the intermammary cleft that normally divides them. It can be surgically corrected by a plastic surgeon through symmastia revision. Symmastia can either be a congenital anomaly or iatrogenic. Congenital symmastia is a rare condition with few published cases.
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Aphakia is the absence of the lens of the eye, due to surgical removal, such as in cataract surgery, a perforating wound or ulcer, or congenital anomaly. It causes a loss of accommodation, high degree of farsightedness (hyperopia), and a deep anterior chamber. Complications include detachment of the vitreous or retina, and glaucoma. Babies are rarely born with aphakia.
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Midline cervical clefts are a rare congenital anomaly resulting from incomplete fusion during embryogenesis of the first and second branchial arches in the ventral midline of the neck. The condition presents as a midline cutaneous defect of the anterior neck with a skin projection or sinus, or as a subcutaneous erythematous fibrous cord. Surgical excision is the preferred treatment.
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Cozzutto C(1981). Uterus-like mass replacing ovary: Report of a new entity. Arch Pathol Lab Med 105: 508-514. Different pathogenetic views have been suggested for this anomaly: a) a metaplastic change in endometriosis foci bringing about smooth muscle hyperplasia; b) a congenital anomaly due to fusion defects of the Muellerian ducts; and c) a sub-coelomic transformation of the mesenchyme.
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The two main subcategories of lower extremity prosthetic devices are trans-tibial (any amputation transecting the tibia bone or a congenital anomaly resulting in a tibial deficiency), and trans-femoral (any amputation transecting the femur bone or a congenital anomaly resulting in a femoral deficiency). In the prosthetic industry, a trans-tibial prosthetic leg is often referred to as a "BK" or below the knee prosthesis while the trans-femoral prosthetic leg is often referred to as an "AK" or above the knee prosthesis. Other, less prevalent lower extremity cases include the following: # Hip disarticulations – This usually refers to when an amputee or congenitally challenged patient has either an amputation or anomaly at or in close proximity to the hip joint. # Knee disarticulations – This usually refers to an amputation through the knee disarticulating the femur from the tibia.
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Cryptophthalmos is a rare congenital anomaly in which the skin is continuous over the eyeball with absence of eyelids. It is classified into three types: complete, incomplete and abortive. Failure of eyelid separation can be associated with maldevelopment of the underlying cornea and microphthalmia. Cryptophthalmos usually occurs on both sides and occurs in association with multiple other malformations collectively referred to as Fraser syndrome.
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The several components or degrees of development range from an ear tag, preauricular appendage, preauricular tag, or accessory tragus, to supernumerary ears or polyotia. It is a relatively common congenital anomaly of the first branchial arch or second branchial arches. Other anomalies may be present concurrently, including cleft palate, cleft lip, or mandibular hypoplasia. There is a known association with Goldenhar syndrome (oculo-auriculo-vertebral syndrome) and with Wildervanck syndrome.
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The Dandy–Walker malformation is a congenital malformation associated with hydrocephalus. In 1921 Dandy reported a case of hydrocephalus caused by obstruction of outflow of CSF from the fourth ventricle. In 1944 A. Earl Walker (who eventually became chairman of neurosurgery at Johns Hopkins) described a similar case of congenital closure of the outflow of the fourth ventricle. This congenital anomaly became known as the Dandy-Walker cyst.
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Paramethadione (brand name Paradione) was originally approved by the U.S. Food and Drug Administration (FDA) in 1949, as a second-line treatment for petit mal and absence seizures. Paramethadione was ultimately discontinued in 1994 due to safety and efficacy concerns,Drug information for PARADIONE such as being associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007.
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Coloboma of optic nerve, is a rare defect of the optic nerve that causes moderate to severe visual field defects. Coloboma of the optic nerve is a congenital anomaly of the optic disc in which there is a defect of the inferior aspect of the optic nerve. The issue stems from incomplete closure of the embryonic fissure while in utero. A varying amount of glial tissue typically fills the defect, manifests as a white mass.
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Sclerocornea is a congenital anomaly of the eye in which the cornea blends with sclera, having no clear-cut boundary. The extent of the resulting opacity varies from peripheral to total (sclerocornea totalis). The severe form is thought to be inherited in an autosomal recessive manner, but there may be another, milder form that is expressed in a dominant fashion. In some cases the patients also have abnormalities beyond the eye (systemic), such as limb deformities and craniofacial and genitourinary defects.
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In 2008 Kurinczuk was made Deputy Director, and in 2011 Director of the National Perinatal Epidemiology Unit. Her research considers the physical and mental health of mothers and babies, and how research can be used to inform policy. In particular, Kurinczuk studies the origins and consequences of neonatal encephalopathy, a neurological disorder that occurs in the earliest days of life. She led the Congenital Anomaly Register (CAR) for Oxfordshire, Berkshire and Buckinghamshire (OBB), a portal that collected information on babies born with congenital abnormalities.
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The hospital performed the country’s first successful surgical separation of the rare congenital anomaly of conjoined Tetrapus Ischiopagus twins. Dr. Raul G. Fores immediately approved their transfer to MakatiMed's pediatric nursery, where they were raised by the pediatric staff until they were ready to be operated on. The MakatiMed team took nine months of preparation, planning, and mock exercises before the actual operation took place. In May 1998, pediatricians, plastic surgeons, pediatric surgeons, urologists, orthopedic surgeons, anesthesiologists, nurses, and operating room attendants spent 17 hours operating.
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Pancreatic divisum is a congenital anomaly in the anatomy of the ducts of the pancreas in which a single pancreatic duct is not formed, but rather remains as two distinct dorsal and ventral ducts. Most individuals with pancreas divisum remain without symptoms or complications. A minority of people with pancreatic divisum may develop episodes of abdominal pain, nausea or vomiting due to acute or chronic pancreatitis. The presence of pancreas divisum is usually identified with cross sectional diagnostic imaging, such as MRI or computed tomography (CT) imaging.
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Enophthalmos is the posterior displacement of the eyeball within the orbit due to changes in the volume of the orbit (bone) relative to its contents (the eyeball and orbital fat), or loss of function of the orbitalis muscle. It should not be confused with its opposite, exophthalmos, which is the anterior displacement of the eye. It may be a congenital anomaly, or be acquired as a result of trauma (such as in a blowout fracture of the orbit), Horner's syndrome (apparent enophthalmos due to ptosis), Marfan syndrome, Duane's syndrome, silent sinus syndrome or phthisis bulbi.
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An enlarged clitoris due to clitoromegaly Modifications to the clitoris can be intentional or unintentional. They include female genital mutilation (FGM), sex reassignment surgery (for trans men as part transitioning, which may also include clitoris enlargement), intersex surgery, and genital piercings. Use of anabolic steroids by bodybuilders and other athletes can result in significant enlargement of the clitoris in concert with other masculinizing effects on their bodies. Abnormal enlargement of the clitoris may also be referred to as clitoromegaly, but clitoromegaly is more commonly seen as a congenital anomaly of the genitalia.
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Bladder exstrophy is a congenital anomaly that exists along the spectrum of the exstrophy-epispadias complex, and most notably involves protrusion of the urinary bladder through a defect in the abdominal wall. Its presentation is variable, often including abnormalities of the bony pelvis, pelvic floor, and genitalia. The underlying embryologic mechanism leading to bladder exstrophy is unknown, though it is thought to be in part due to failed reinforcement of the cloacal membrane by underlying mesoderm.Muecke EC: The role of the cloacal membrane in exstrophy: the first successful experimental study.
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Invert described the opposite gender roles, and also the related attraction to women instead of men; since women in the Victorian period were considered unable to initiate sexual encounters, women who did so with other women were thought of as possessing masculine sexual desires.Jennings, p. 77. The work of Krafft-Ebing and Ellis was widely read, and helped to create public consciousness of female homosexuality. The sexologists' claims that homosexuality was a congenital anomaly were generally well-accepted by homosexual men; it indicated that their behavior was not inspired by nor should be considered a criminal vice, as was widely acknowledged.
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Ankyloglossia Ankyloglossia, also known as tongue-tie, is a congenital anomaly characterised by an abnormally short lingual frenulum; when severe, the tip of the tongue cannot be protruded beyond the lower incisor teeth. Additionally, an abnormally short frenulum in infants can be a cause of breastfeeding problems, including sore and damaged nipples and inadequate feedings. The resultant trouble breastfeeding results in slower weight gain in affected infants. The absence of the inferior labial (100% sensitivity; 99.4% specificity) and lingual frenulum (71.4% sensitivity; 100% specificity) was found to be associated with classical and hypermobility types of Ehlers-Danlos syndrome.
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It is attached to the lining of the knee joint along its periphery and serves to absorb about a third of the impact load that the joint cartilage surface sees and also provides some degree of stabilization for the knee. There are two menisci in the knee joint, with one on the outside (away from midline) being the lateral meniscus and the inner one (towards midline) the medial meniscus. A discoid meniscus is a congenital anomaly of the knee found in 3% of the population (up to 15% in Asia). It typically affects the lateral meniscus and may be found bilaterally (20%).
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Poland syndrome is a congenital anomaly in which there is a malformation of the chest causing the pectoralis major on one side of the body to be absent. Other characteristics of this disease are "unilateral shortening of the index, long, and ring fingers, syndactyly of the affected digits, hypoplasia of the hand, and the absence of the sternocostal portion of the ipsilateral pectoralis major muscle".www.polands-syndrome.com Although the absence of a pectoralis major is not life-threatening, it will have an effect on the person with Poland's syndrome. Adduction and medial rotation of the arm will be much harder to accomplish without the pectoralis major.
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Anomalous left coronary artery from the pulmonary artery (ALCAPA or Bland- White-Garland syndrome or White-Garland syndrome) is a rare congenital anomaly in which the left coronary artery (LCA) branches off the pulmonary artery instead of the aortic sinus. After birth, the pressure in other coronary arteries (namely the RCA) will have a pressure that exceeds the LCA and collateral circulation will increase. This, ultimately, can lead to blood flowing from the RCA into the LCA (retrograde) and into the pulmonary artery, thus forming a left-to-right shunt. The syndrome is named for Edward Franklin Bland, Paul Dudley White, and Joseph Garland.
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Asymmetric crying facies (ACF), also called partial unilateral facial paresis and hypoplasia of depressor angula oris muscle, is a minor congenital anomaly caused by agenesis or hypoplasia of the depressor anguli oris muscle, one of the muscles that control the movements of the lower lip. This unilateral facial weakness is first noticed when the infant cries or smiles, affecting only one corner of the mouth and occurs on the left side in nearly 80% of cases. It is only rarely associated with other birth defects. When the hypoplasia of the depressor anguli oris muscle is associated with congenital cardiac defects, the term 'Cayler cardiofacial syndrome' is used.
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A Type I Chiari malformation is a congenital anomaly of the brain in which the cerebellar tonsils are elongated and pushed down through the opening of the base of the skull (see foramen magnum), blocking the flow of cerebrospinal fluid (CSF) as it exits through the medial and lateral apertures of the fourth ventricle. Also called cerebellar tonsillar ectopia, or tonsillar herniation. Although often congenital, Chiari malformation symptoms can also be induced due to physical head trauma, commonly from raised intracranial pressure secondary to a hematoma, or increased dural strain pulling the brain caudally into the foramen magnum. Head trauma increases risk of cerebellar tonsillar ectopia by a factor of 4.
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The verumontanum is an important anatomic landmark for pathology in a congenital anomaly known as posterior urethral valves, in which there is a developmental obstruction of the urethra in newborn male infants. Urethral carcinoid tumors have been reported at the verumontanum.Maxwell Smith, M Scott Lucia, Priya N Werahera and Francisco G La Rosa Carcinoid tumor of the verumontanum (colliculus seminalis) of the prostatic urethra with a coexisting prostatic adenocarcinoma: a case report Journal of Medical Case Reports 2010, 4:16 The structure tends to migrate caudally, or downward, in hypospadia disorders and is then seen in the bulbous, or penile portion of the urethra.F Ikoma, H Shima. 1991.
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Fetal trimethadione syndrome (also known as paramethadione syndrome, German syndrome, tridione syndrome, among othersAdditional names include trimethadione embryopathy and trimethadione syndrome.) is a set of birth defects caused by the administration of the anticonvulsants trimethadione (also known as Tridione) or paramethadione to epileptic mothers during pregnancy.Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007 Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health's Office of Rare Diseases,Fetal trimethadione syndrome on the ORD website. Retrieved January 2007 meaning it affects less than 200,000 individuals in the United States.NIH's Office of Rare Diseases Retrieved January 2007 The fetal loss rate while using trimethadione has been reported to be as high as 87%.
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The study noted that the statistics for Oregon were different for other areas, such as British Columbia, which had different licensing requirements. Oregon was noted by the Centers for Disease Control and Prevention as having the second-highest rate of home births in the nation in 2009, at 1.96% compared to the national average of 0.72%. A 2014 survey of nearly 17,000 voluntarily reported home births in the United States between 2004 and 2010 found an intrapartum infant mortality rate of 1.30 per thousand; early neonatal and late neonatal mortality rates were a further 0.41 and 0.35 per thousand. The survey excluded congenital anomaly-related deaths, as well as births where the mother was transferred to a hospital prior to beginning labor.
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An adverse event (AE) is any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. An adverse event (AE) can therefore be any unfavourable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product.ICH GCP AEs in patients participating in clinical trials must be reported to the study sponsor and if required could be reported to local ethics committee. Adverse events categorized as "serious" (results in death, illness requiring hospitalization, events deemed life-threatening, results in persistent or significant disability/incapacity, a congenital anomaly/birth defect or medically important condition) must be reported to the regulatory authorities immediately, whereas non-serious adverse events are merely documented in the annual summary sent to the regulatory authority.
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