Similarly to NSAIDs, adverse effects of naproxcinod include gastrointestinal bleedings.
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In a study conducted with 150 patients aged twelve and above, adolescents after using turoctocog alfa as a treatment, had an average of 5.55 bleedings per year while the adults had an average of 6.68 bleeding per year. According to data, turoctocog alfa was considered an 'excellent' treatment for 403 out of 499 bleeding episodes. In another study involving 63 patients aged less than twelve years, children had an average of 5.33 bleedings per year after using turoctocog alfa as hemophilia treatment. In this study too turoctocog alfa was considered as an 'excellent' treatment for 116 out of 126 bleeding episodes.
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In September, they toured North American again, this time supporting Toxic Holocaust. They released their second EP, Season's Bleedings, in December 2011. In February 2012, the band performed at Australia's Soundwave festival. In March, they supported Saviours on another North American tour, including a performance at Austin's South by Southwest festival.
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Medical attendants thus intentionally removed more than half of the patient's normal blood supply—in addition to the initial blood loss which caused the sergeant to faint. Bleedings continued over the next several days. By 29 July, the wound had become inflamed. The physician applied 32 leeches to the most sensitive part of the wound. Over the next three days, there were more bleedings and a total of 40 more leeches. The sergeant recovered and was discharged on 3 October. His physician wrote that "by the large quantity of blood lost, amounting to 170 ounces [nearly eleven pints] (4.8 liters), besides that drawn by the application of leeches [perhaps another two pints] (1.1 liters), the life of the patient was preserved".
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Awarded with the Order of the White Eagle in August 1727. The treatment of his medical problems included 56 bleedings, 30 applications of leeches, and 13 cuppings. These treatments have been described as illustrative demonstrations of medical interventions available to the wealthy at the time. His former lover was Maria Karolina Sobieska, grand daughter of John III Sobieski.
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Gonyautoxins can be used as treatment against acute or chronic anal fissures. The toxins help the muscle to relax and hence kill the pain. In a study, the bleedings of the poisoned patients stopped within 48 hours. This is thanks to a temporary paralysis at the injection-area, which appears to last for over one week.
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There are 60 medical and medical-health establishments in a city — hospitals, polyclinics, the station of blood transfusion, station of urgent medicare, sanatoriums, sanatoriums-preventive clinics, regional centre of social maintenance of pensionaries and invalids, city centres: gastroenterology, thoracic surgery, bleedings, pancreatic, microsurgery of the eye. Central pool-hospital on a water-carriage. The largest hospital is the Mariupol regional intensive care hospital.
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Women facing execution ovulated less predictably, he found, and sometimes experienced what he called "shock bleedings". One paper argued that the Knaus–Ogino rhythm method of contraception was ineffective due to the variations of the cycle. Despite Stieve's errors in understanding the physiology, his conclusion is still accepted as correct. Since he took care of all the prison's bodies, he had some influence with officials there.
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Later betrixaban was studied in a large phase III clinical trial ("APEX") for extended duration thromboprophylaxis in acute medically ill patients. Previously apixaban and rivaroxaban have failed to show positive risk/benefit ratio in this indication compared to enoxaparin. APEX trial compared betrixaban with enoxaparin and included 7513 patients. Lower rate of VTE events was found in betrixaban arm with no increase in major bleedings compared to enoxaparin.
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The fish shown loss of balance and severe bleedings and died within only 4–6 minutes. Similar effects were observed when the toxin was injected in mice. Latrunculin makes up to 0.35% of the dry weight of the sponge. There are two main forms of the toxin, A and B. Latrunculin A is only present in sponges which live in the gulf of Suez while latrunculin B only exist in sponges in the gulf of Eilat.
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Until that point, prayer and medical treatments ("potions, baths, unctions, and thirty bleedings") had proven futile. After the Mother-Superior's novena, Sister Catherine soon attempted to walk, and found herself increasingly mobile; the illness no longer seemed present. The painting is a statement of gratitude by the father for the cure of his daughter. The miracle it portrays also symbolized hope for the cause of the Jansenists, who were subject to persecution by ecclesiastical and civil authorities.
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The aim is to determine the optimal therapeutic window to maximize therapeutic benefits while reducing safety concerns like bleeding. Consequently, the major unmet goal of ADP inhibitors is to develop a potent reversible antiplatelet agent with fast onset of action, high levels of antiplatelet activity yet decreased risk of bleedings. This challenging goal together with a once-daily oral profile and optimized target selectivity would possibly be an important breakthrough in this field. Vicagrel is the latest development, as of September 2017, in this sector.
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Without treatment, NTG leads to progressive visual field loss and in the last consequence to blindness. The mainstay of conventional glaucoma therapy, reducing IOP by pressure-lowering eye drops or by surgery, is applied in cases of NTG as well. The rationale: the lower the IOP, the less the risk of ganglion cell loss and thus in the long run of visual function. The appearance of disc hemorrhages is always a warning sign that therapeutic approaches are not successful - the small bleedings, usually described as flame-shaped, almost always indicate a progression of the disease.
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In several of his plays, Molière depicted the physicians of his day as pompous individuals who speak (poor) Latin to impress others with false erudition, and know only clysters and bleedings as (ineffective) remedies. After the Mélicerte and the Pastorale comique, he tried again to perform a revised Tartuffe in 1667, this time with the name of Panulphe or L'Imposteur. As soon as the King left Paris for a tour, Lamoignon and the archbishop banned the play. The King finally imposed respect for Tartuffe a few years later, after he had gained more power over the clergy.
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William Cullen Bryant Memorial in Bryant Park adjacent to the New York Public Library Sunshine Cottage Administration Building New York Medical College owes its founding in 1860 to a group of civic leaders who believed that medical studies should be practiced with a better understanding of what the patient needs. This group of civic leaders was led by the noted poet William Cullen Bryant who was an editor of the New York Evening Post. Bryant was concerned about the condition of hospitals and medical education in New York City. His main concern was with some of the medical practices being used to treat disease, which at the time included bleedings, purges, and the administration of strong drugs in too large doses.
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This may also occur at the same time as menstrual spotting. The term breakthrough bleeding or breakthrough spotting is usually used for women using hormonal contraceptives, such as IUDs or oral contraceptives, in which it refers to bleeding or spotting between any expected withdrawal bleedings, or bleeding or spotting at any time if none is expected. If spotting continues beyond the first 3-4 cycles of oral contraceptive use, a woman should have her prescription adjusted to a pill containing higher estrogen:progesterone ratio by either increasing the estrogen dose or decreasing the relative progestin dose. Besides the aforementioned physiologic forms, metrorrhagia may also represent abnormal uterine bleeding and be a sign of an underlying disorder, such as hormone imbalance, endometriosis, uterine fibroids, uterine cancer, or vaginal cancer.
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The use of LMWHs should be avoided in patients with known allergies to LMWHs, heparin, sulfites or benzyl alcohol, in patients with active major bleeding, or patients with a history of heparin- induced low blood platelet count (also known as heparin-induced thrombocytopenia or HIT). High treatment doses are contraindicated in acute bleedings such as cerebral or gastrointestinal haemorrhage. LMWHs are more dependent on renal function for their excretion than unfractionated heparin so their biological half-life may be prolonged in patients with kidney failure and therefore their use in the setting of creatinine clearance rate (CrCl) <30 mL/min may need to be avoided. Apart from using unfractionated heparin instead, it may be possible to reduce the dose and/or monitor the anti-Xa activity to guide treatment.
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Lear would record the account in his journal, writing that Washington's last words were "'Tis well." Discovering the case to be highly alarming, and foreseeing the fatal tendency of the disease, two consulting physicians were immediately sent for, Elisha Dick who arrived, at half after three, and Gustavus Richard Brown, at four o'clock in the afternoon: in the meantime were employed two pretty copious bleedings, a blister was applied to the part affected, two moderate doses of calomel were administered, which operated on the lower intestines, but all without any perceptible advantage, the respiration becoming still more difficult and distressing. Upon the arrival of the first of the consulting physicians, it was agreed, as there were yet no signs of accumulation in the bronchial vessels of the lungs, to try the result of another bleeding, when about thirty-two ounces of blood were drawn, without the smallest apparent alleviation of the disease. Vapours of vinegar and water were frequently inhaled, ten grains of calomel were given, succeeded by repeated doses of emetic tartar, amounting in all to five or six grains, with no other effect than a copious discharge from the bowels.
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