4 Sentences With "assisted zona hatching"

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In some situations, the term "hatching" is used only for artificial ways to free the blastocyst from the zona pellucida, and not the natural lysis of it. An example of such artificial way is assisted zona hatching.
People who have experienced repeatedly failed implantation, or whose experimental embryo has a thick zona pellucida (covering) around the embryo, have ideal candidates for assisted zona hatching. The procedure involves creating a hole in the zona to improve the chances of normal implantation of the embryo in the uterus.
Assisted zona hatching (AZH) is a procedure of assisted reproductive technology in which a small hole is made in the zona pellucida, using a micromanipulator, thereby facilitating for zona hatching to occur.IVF- infertility.com Zona hatching is where the blastocyst gets rid of the surrounding zona pellucida to be able to implant in the uterus.
A systematic review and meta-analysis came to the result that assisted zona hatching is related to increased rates of clinical pregnancy and multiple pregnancy in women with previous repeated failure or frozen-thawed embryos. However, it is unlikely to increase clinical pregnancy rates when performed in fresh embryos transferred to unselected women, to those without poor prognosis or to women of advanced maternal age. Also, overall, there no evidence of a significant difference in live birth rate following assisted hatching compared with no assisted hatching.