Cisordinol 10 mg tablet Zuclopenthixol antagonises both dopamine D1 and D2 receptors, α1-adrenoceptors and 5-HT2 receptors with a high affinity, but has no affinity for cholinergic muscarine receptors. It weakly antagonises the histamine (H1) receptor but has no α2-adrenoceptor blocking activity . Evidence from in vitro work and clinical sources (i.e. therapeutic drug monitoring databases) suggests that both CYP2D6 and CYP3A4 play important roles in zuclopenthixol metabolism.
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Since it competitively antagonises the effects of LSD, it may be regarded as a protomer antagonist of the 5-HT2A-mGluR heteromer. GPCR oligomers are discrete entities and usually possess properties distinct from their parent monomeric receptors.
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In human preterm labour, atosiban, at the recommended dosage, antagonises uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
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CCX832 is an orally active molecule used as a tool compound in experimental pharmacology. It antagonises the effect of CMKLR1. It is listed on the Guide to Pharmacology database as the only example of a CMKLR1 antagonist. Its chemical structure is undisclosed.
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When Peter finds out, he attacks Rob. On Christmas Day 2013, a drunken Kylie antagonises Tina and Rob escorts Kylie out. Tina follows and when she insults Kylie for sleeping with Nick, Kylie punches her. Another catfight breaks out and the police arrest Kylie for assault.
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The class IA PI3K p110α is mutated in many cancers. Many of these mutations cause the kinase to be more active. It is the single most mutated kinase in glioblastoma, the most malignant primary brain tumor. The PtdIns(3,4,5)P3 phosphatase PTEN that antagonises PI3K signaling is absent from many tumours.
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Mala suspects that Chandrasekhar's classmate Ramya is his concubine since he visits her often. Chandrasekhar learns of Ramya's love for him only after his marriage to Mala. Ramya remains single and they share a platonic relationship, which antagonises Mala. Pratap, a photographer and distant relative of Chandrasekhar, comes to Chennai from Calcutta.
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Inadmissible Evidence is a 1968 British drama film directed by Anthony Page and starring Nicol Williamson and Jill Bennett. John Osborne wrote the screenplay, adapting his own 1964 play Inadmissible Evidence.Murphy p.140 The film portrays the collapse of an angry but sad man, who cannot maintain decent standards in his life and antagonises everybody.
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NO also reduces pulmonary smooth muscle cell growth and antagonises platelet inhibition, factors which play a key role in the pathogenesis of PAH. In contrast to NO- and haem-independent sGC activators like cinaciguat, the sGC stimulator riociguat directly stimulates sGC activity independent of NO and also acts in synergy with NO to produce anti-aggregatory, anti-proliferative, and vasodilatory effects.
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Jocelyn blocks off the corridor by activating the fire doors, then escorts the Doctor to Dashiel in the cocktail lounge. Mrs Wingsworth antagonises the badgers and is once again disintegrated. While the Doctor attempts to negotiate, Archibald offers him some of the canapés, which continue to be replenished. Mrs Wingsworth enters the cocktail lounge again, explaining that the passengers are brought back to life after they die.
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Opioid receptor antagonists are regarded as practical in lessening urge-related symptoms, which is a central part of impulse control disorders; for this reason, they are used in treatment of substance abuse. This quality makes them helpful in treating kleptomania and impulse control disorders in general. The most frequently used drug is naltrexone, a long-acting competitive antagonist. Naltrexone acts mainly at μ-receptors, but also antagonises κ- and λ-receptors.
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The 245 nucleotide sRNA of Escherichia coli, CsrC, was discovered using a genetic screen for factors that regulate glycogen biosynthesis. CsrC RNA binds multiple copies of CsrA, a protein that post-transcriptionally regulates central carbon flux, biofilm formation and motility in E. coli. CsrC antagonises the regulatory effects of CsrA, presumably by sequestering this protein. The discovery of CsrC is intriguing, in that a similar sRNA, CsrB, performs essentially the same function.
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Robert identifies Forrester as a traitor and murderer. While Kayron sets out to hunt Forrester down in revenge, a series of attacks takes place on research stations across the Galactic Union (GU). The attacking ships, identified simply as drones, appear to be a type of vessel completely unknown to the GU, and Robert convinces the Galactic Council that they are of Thul origin, a genetically engineered human civilization. This antagonises all races within the Galactic Union against the Thul.
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Drug dealer Callum Logan (Sean Ward), the biological father of Max Turner (Harry McDermott), harasses the Platt family for custody of Max for several months. He particularly antagonises David Platt (Jack P. Shepherd), due to his remarks about Max's mother and David's wife, Kylie (Paula Lane). Callum begins a relationship with Sarah Platt (Tina O'Brien), to the Platts' dismay. Callum manipulates Sarah's teenage daughter Bethany Platt (Lucy Fallon) to buy drugs for him whilst he films her.
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Richard Cole arrives in Walford in 1992 as the new market inspector. He is known as a corrupt man who will pull every trick in the book to make money and he is not well liked by the community. He is also a notorious womaniser who has various brief flings. He briefly dates market trader Rachel Kominski (Jacquetta May) in 1992, but antagonises her later when he decides to give her permanent market pitch to his newly arrived friend, Sanjay Kapoor (Deepak Verma).
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She uses a reverse genetic system to better manipulate the viral genome. Reverse genetics helps to understand the function of a gene through the analysis of phenotypic effects of nucleic acid sequences. She looks to understand what determines coronavirus viral and cellular tropism, as well as better understanding the pathogenesis of coronavirus in the brain. This has involved studies of the interferon antagonists that are encoded by the coronavirus, specifically phosphodiesterase, which antagonises OAS-RNase L (Ribonuclease L) immune pathway.
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The novel is primarily written from the perspective of Renisenb, a young widow reacquainting herself with her family when her father Imhotep, a successful but pompous and short-sighted mortuary priest, brings a new "wife", Nofret, into their lives. Nofret soon disrupts and antagonises Imhotep's sons - Yahmose, Sobek and Ipy - as well as their wives. Renisenb realises the housekeeper Henet, while feigning devotion, is full of hatred. She eventually confronts Henet, who in a fit of pique admits she hates Renisenb and hated Renisenb's long-deceased mother.
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GnSAF antagonises the positive feedback effects of estradiol on GnRH-induced LH release during the follicular phase. GnSAF inhibits the stimulatory role of estradiol in increasing GnRH- induced de novo synthesis of GnRH receptors in the pituitary. GnRH receptor mRNA levels are low in the presence of high GnSAF bioactivity, which limits the availability of binding sites for GnRH at the pituitary and decreased pituitary sensitivity to GnRH. The moderated GnRH pulse amplitude and frequency is sufficient for maintaining low blood concentrations of LH and protects against premature LH surges and LH hypersecretion.
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The facts seem straightforward and the only mysteries are the motive and the origin of the gun. Rebus antagonises the survivor's father, an aggressive local MP who dislikes the police and is trying to make political capital out of the shooting. He also meets his long-lost cousin, whose son was one of the killer's victims and whose daughter is now being sucked into the MP's campaign. He and Clarke try to trace the gun to a local gangster, and continue on the case when Rebus is officially suspended on suspicion of murdering Clarke's stalker.
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Examples of feedback control in the PI3K-Akt Pathway The PI3K-Akt pathway has many downstream effects and must be carefully regulated. One of the ways the pathway is negatively regulated is by reducing PIP3 levels. Phosphatase and tensin homolog (PTEN) antagonises PI3K by converting PI(3,4,5)P3 into PI(4,5)P2. Loss of PTEN function leads to over-activation of Akt and is common in cancer cells (PTEN is a tumour suppressor). SH2-containing Inositol Phosphatase (SHIP) also dephosphorylates PI(3,4,5)P3, at the 5' position of the inositol ring.
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Snip orders him around, acts in a rowdy manner and antagonises him. Clyde becomes too annoyed so he throws Snip and his friends out of The Vic one night, much to the anger of Phil and Grant, who are trying to secure a business deal with Snip. When Snip and his friends refuse to vacate the pub after closing time one evening, Clyde threatens to quit his job unless they leave. They don't, so Clyde quits but he contacts his boss, Sharon Mitchell (Letitia Dean), who is holidaying in America.
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Linear motif mediated protein-protein interactions have shown promise in recent years as novel drug targets. Success stories include the MDM2 motif analog Nutlin-3 and integrin targeting RGD-mimetic Cilengitide: Nutlin-3 antagonises the interaction of MDM2's SWIB domain with p53 thus stabilising p53 and inducing senescence in cancer cells. Cilengitide inhibits integrin-dependent signaling, causing the disassembly of cytoskeleton, cellular detachment and the induction of apoptosis in endothelial and glioma cells. In addition, peptides targeting the Grb2 and Crk SH2/ SH3 adaptor domains are also under investigation.
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Weiss has considered the mechanisms by which the phosphodiesterase antagonises Ribonuclease L. She has studied the role of inflammasome-related cytokines in mouse hepatitis virus-induced disease. Despite murine coronavirus being a useful model of coronaviruses, it is still unclear how mouse hepatitis virus is spread. There is only one receptor for the mouse hepatitis virus – the carcinoembryonic antigen – but highly virulent strains of the virus can spread even when this receptor is not present. In 2020, Weiss was made co-Director of the University of Pennsylvania Center of Research for Coronaviruses and Other Emerging Pathogens.
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Tilidine Tilidine is used in the form of hydrochloride or phosphate salt. In Germany, tilidine is available in a fixed combination with naloxone for oral administration (Valoron N and generics); the mixture of naloxone is claimed to lower the abuse liability of the opioid analgesic. This is so that if people take the medication orally (which is the way they are meant to) the opioid blocker, naloxone, has minimal effects on them but if they inject it the naloxone becomes bioavailable and hence antagonises the effects of the tilidine producing withdrawal effects. In Switzerland the original Valoron brand with only tilidine and no naloxone is also available.
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Scene 2 – A Room in the Palace (Three years later): Tyi is regent of Egypt until Akhnaton comes of age. The young man shows little interest in ruling as his father had done and antagonises Meriptah. It is revealed that it was Tyi who instilled in Akhnaton a dislike of the religion of Amon and a reverence of Ra when he was a child. In conversation with another priest, Ay, Akhnaton realises his destiny and that he is the son of Ra. He gives orders that his barge be prepared for a voyage down the Nile to a spot where he will build a new city to the glory of Ra. Nefertiti is introduced.
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The jurors of the trial voted the guilt of Socrates by a relatively narrow margin(36a). In the Apology of Socrates, Plato cites no total numbers of votes condemning or acquitting the philosopher of the accusations of moral corruption and impiety; Socrates says that he would have been acquitted if thirty more jurors had voted in his favour. In such cases — where the penalty of death might arise as a legal sanction for the accusations is presented — Athenian law required that the prosecutor and the defendant each propose an administrative penalty to punish the actions reported in the accusations. Socrates antagonises the court by proposing, rather than a penalty, a reward — perpetual maintenance at public expense.
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The courts have accepted than an employee whose actions negatively affect the operation of a business may be dismissed. This may occur where certain actions of the employee create disharmony among his co-workers, as when, for example, he antagonises co-workers by continually making racist or sexist remarks. In Erasmus v BB Bread, employees called for the dismissal of a manager because of his problematic attitude towards them, and his having made derogatory remarks, particularly aimed at black employees. The Industrial Court (in terms of the old LRA) held that his dismissal was for a valid and fair reason, as the employer is entitled to insist on reasonably harmonious interpersonal relationships between employees.
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Syme demurs, insisting the essence of poetry is not revolution but law. He antagonises Gregory by asserting that the most poetical of human creations is the timetable for the London Underground. He suggests Gregory isn't really serious about anarchism, which so irritates Gregory that he takes Syme to an underground anarchist meeting place, under oath not to disclose its existence to anyone, revealing his public endorsement of anarchy is a ruse to make him seem harmless, when in fact he is an influential member of the local chapter of the European anarchist council. The central council consists of seven men, each using the name of a day of the week as a cover; the position of Thursday is about to be elected by Gregory's local chapter.
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Geoff and Sally are held captive, and matters take a turn for the worse when Juan and his men also arrive on the scene, forcing a stand-off between the two factions during which Geoff and Sally are roughly-treated by both sides. Duke starts to fall for Sally, and his obvious interest in her antagonises his girlfriend Rina (Zena Marshall). Eventually there is a bloody shoot-out between the rival gangs, with Duke's men getting the better of the exchange. Duke and his gang board the plane to make good their escape with the valuables, but the plane is shot at before take-off by the jealous and vengeful Rina, first shooting the pilot and then hitting the fuel tank after which the plane bursts into flames killing all 4 people onboard.
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