According to the drugmaker's website, meldonium is primarily used to treat heart-related conditions — like angina pectoris and heart failure — that block blood and oxygen to the heart muscle.
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FISA said Fedorovtsev's 'A' and 'B' samples tested positive for the substance, which is typically used for the treatment of the heart condition angina pectoris and is a banned metabolic modulator.
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Originally a medication developed by Pfizer to treat angina pectoris (chest pain due to heart disease) and hypertension (high blood pressure), Sildenafil suddenly revealed itself to be quite effective at making penises stand at attention.
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Circ Res 1987, 60: 540–550. # Ellingsen Ø, Kjekshus J. Prazosin ved anstrengelsesutløst angina pectoris (Prazosin in exercise induced angina pectoris). Tidsskr Nor Lægeforen 1984, 104: 657 660.
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He is also well known for developing the Canadian Cardiovascular Society grading of angina pectoris.
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Pindolol has modest beta-adrenergic agonist activity and is therefore used with caution in angina pectoris.
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On one such trip to London with his daughter, he was struck by angina pectoris and died.
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Elizabeth Crotty died on 27 December 1960 from angina pectoris. She is buried in (old) Shanakyle cemetery.
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He died in New Orleans of angina pectoris on October 12, 1920, and was interred in Metairie Cemetery.
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They had one son, William Robert Mercer, born in 1901. Duff died in May 1922 from angina pectoris.
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An antianginal is a drug used in the treatment of angina pectoris, a symptom of ischaemic heart disease.
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Common side effects include hypertension, tachycardia, headache, dizziness, drowsiness and symptoms similar to angina pectoris. Severe allergic reactions are rare.
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Bennett was never married. She died of angina pectoris at the New York infirmary in 1925 and was buried in Wrentham, Massachusetts.
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The most critical nondental source is the radiation of angina pectoris into the lower teeth and the potential need for urgent cardiac care.
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Thomas Jones died in 1803; the cause of death was angina pectoris. He was buried at the family chapel at Caebach, Llandrindod Wells.
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Together they won the doubles title in 1896 and 1900. Whitney retired from active tennis in 1902 on doctor's orders due to angina pectoris.
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Not to be used with heart diseases, angina pectoris and decompensated cardiac insufficiency, glaucoma, hyper-excitability and thyrotoxicosis or while treated with monoamine oxidase inhibitors.
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Demircan et al. found that the CIMT of patients with acute coronary syndrome were significantly increased compared to patients with stable angina pectoris. It has been reported in another study that a maximal CIMT value of 0.956 mm had 85.7% sensitivity and 85.1% specificity to predict angiographic CAD. The study group consisted of patients admitted to the cardiology outpatient clinic with symptoms of stable angina pectoris.
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Vice President Clement Archer was elected in Hume's place. Hume's medical writings were on the subjects of the diseases of children, angina pectoris, cowpox, and gout.
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In January 1957, the following year after his visit to the USSR, Shigemitsu died of angina pectoris, at 69, at his summer home in Yugawara, Kanagawa.
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These include conditions caused by a restricted blood supply to the muscle including angina pectoris and myocardial infarction, and other heart muscle diseases known as cardiomyopathies.
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Angina pectoris, an unfortunate symptom of Ischaemic heart disease, is treated with nitroglycerin."Nitroglycerin Sublingual: MedlinePlus Drug Information." Nitroglycerin Sublingual: MedlinePlus Drug Information. N.p., n.d. Web.
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Chesney died suddenly of angina pectoris at his residence, 27 Inverness Terrace, London, on 31 March 1895, and was buried at Englefield Green, Surrey, on 5 April.
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Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure.
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McMahon never married and died after an attack of angina pectoris on April 3, 1911. He is buried in Saint Georges Catholic Cemetery located in Bakersfield, Vermont.
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He died in Los Angeles, California on August 5, 1933, aged 58, of coronary sclerosis and angina pectoris."Theodore C. Lyster" [Obit]; JAMA, 16 Sept 1933, pg 944.
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Maynard lost consciousness in the car and could not be revived. He was pronounced dead at his home in Brookline, Massachusetts. The official cause of death was Angina pectoris.
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Murrell's administration of nitroglycerin to patients with angina pectoris was documented in the article "Nitro-glycerine as a remedy for angina pectoris," published in 1879. The article describes a case series of patients which benefited from the administration of the drug. He also describes in detail the effects of nitroglycerin experienced by testing the drug on himself. Ironically, Alfred Nobel, the inventor of Nitroglycerin for use as an explosive, received nitroglycerin for treatment of angina.
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Imolamine (INN, BAN) (brand names Angolon, Angoril, Circuline, Irri-Cor, Irrigor, Coremax) is a coronary vasodilator which is used in the treatment of angina pectoris and as a local anesthetic.
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In the summer of 1905, Ruflin suffered from angina pectoris. She died on 13 October 1905 at her grandson's mansion in Paris and was buried in the Cimetière des Gonards.
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This (and other) pharmacological effect makes these drugs useful in the treatment of angina pectoris. Conversely, they can lead to symptomatic disturbances in cardiac conduction and bradyarrhythmias, and may aggravate left ventricular failure.
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Saphir became a minister of the Presbyterian Church of England, and received an honorary Doctor of Divinity from the University of Glasgow in 1878. He died of Angina pectoris on 3 April 1891.
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In Egypt, a tea made from the fruit of this species has been used as an herbal remedy for kidney stones. Preparations of Ammi visnaga fruits have also been used for angina pectoris therapy.
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Cardiac bypass is performed when the arteries that bring blood to the heart muscle (coronary arteries) become clogged by plaque. Such a condition may cause chest pain from angina pectoris or a heart attack.
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Because the vasoconstrictive effects of ergotamine and caffeine are not selective for the brain, adverse effects due to systemic vasoconstriction can occur. Cold feet or hands, angina pectoris, myocardial infarction, or dizziness are some examples.
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George T. Snyder (September 27, 1848 – August 2, 1905) was a Major League Baseball pitcher who played in with the Philadelphia Athletics. Snyder died in his home town of Philadelphia, Pennsylvania in 1905 of angina pectoris.
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It is used for the symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm who cannot take beta blockers. It is also being used off- label in the treatment of inappropriate sinus tachycardia.
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Molsidomine is used for the prevention and long-term treatment of stable and unstable angina pectoris, with or without left heart failure. It is also used to treat angina in the context of an acute myocardial infarction.
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In contrast to patients with angina pectoris secondary to coronary artery atherosclerosis, people with variant angina are generally younger and have fewer risk factors for coronary artery disease except for smoking, which is a common and very significant risk factor for both types of angina. Sufferers usually have repeated episodes of unexplained (e.g., in the absence of exertion and occurring at sleep or in the early morning hours) chest pain, light- headedness, excessive sweating, and/or reduced exercise tolerance that, unlike atherosclerosis-related angina pectoris, typically does not progress to myocardial infarction (i.e. heart attack).
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Fostedil (A-53,986, KB-944) is a vasodilator acting as a calcium channel blocker which was under development for the treatment of heart conditions such as angina pectoris but was never marketed. It has antihypertensive and antiarrhythmic effects.
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He became a silent loner, not going anywhere for the last six years of his life. He passed away on May 8, 1888 of Angina pectoris in his apartment, and his funerals took place on May 11, 1888.
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DES manifests as intermittent difficulty swallowing solid foods and liquids (dysphagia), and atypical chest pain. The chest pain may appear similar to cardiac chest pain (angina pectoris), so investigating the possible existence of heart disease is often indicated.
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He had been suffering from angina pectoris for years and had succumbed to the condition. Vernor Smith's great grandson is musician Mac DeMarco, whose birth name—Vernor Winfield McBriare Smith IV—was chosen in honour of the elder Smith.
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Kleinschmidt died on August 2, 1949 as result of a severe angina pectoris diagnosed in 1940. A number of his works include: Berghang am See; Titelblatt der Ausstellung Grafik E.L. Kirchner, Galerie Schames; Kuh mit Frauen; Rosen and Seehaus.
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He was an alternate delegate to the 1928 Republican National Convention, and a delegate to the 1932 Republican National Convention. He died on March 3, 1935, at his home at 71 South Main Street in Dolgeville, New York, of angina pectoris.
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Munk married Emma Beazall in 1873. He died ("of angina pectoris") in Los Angeles 4 Dec 1927. In 1883 Munk became partners in a cattle ranch located near Willcox, Arizona. In 1884 he made his first trip to the state.
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The nitrate esters isosorbide dinitrate (Isordil) and isosorbide mononitrate (Imdur, Ismo, Monoket, Mononitron) are converted in the body to nitric oxide, a potent natural vasodilator. In medicine, these esters are used as a medicine for angina pectoris (ischemic heart disease).
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On 30 June 1900 he left again for Africa, charged with a special mission to delimit the Belgian-German border in Kivu. He returned to Europe on 27 July 1901. He died in Brussels of angina pectoris on 1 October 1902.
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William Murrell (1853–1912) was an English physician, clinical pharmacologist, and toxicologist. Murrell is best known for being one of the first to recognize the clinical benefits of glyceryl trinitrate (also known as nitroglycerin) for the management of patients with angina pectoris.
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After her death in 1898, he married his third wife, Alice Langworthy Leonard on September 14, 1899, in Milan. William E. Howard died April 13, 1917, from "angina pectoris." He was 83 years, 11 months old, buried in Marble Park Cemetery, Milan.
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Burnside died suddenly of "neuralgia of the heart" (Angina pectoris) at Bristol, Rhode Island, and is buried in Swan Point Cemetery, Providence, Rhode Island. An equestrian statue in his honor was erected in the late 19th century in Burnside Park in Providence.
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Robertson died at age 60 on August 20, 1931 of angina pectoris at his summer home in Fontana-on-Geneva Lake, Wisconsin. He was survived by his wife Helen Robertson, who he had married only months earlier, and his son, Dr. Tomas Sanderson Robertson.
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On 8 February 1944, Watson died suddenly at Stoke on Trent, on a train from London to Edinburgh. He was 60 years old. The inquest in Hanley found that he died from angina pectoris, having been weakened by influenza about six weeks before his death.
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Nisoldipine is a pharmaceutical drug used for the treatment of chronic angina pectoris and hypertension. It is a calcium channel blocker of the dihydropyridine class. It is sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels.
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In 1930, he was dangerously bruised and cut when a blowout crashed his motor into a ditch near Levis; he received Extreme Unction but later convalesced.Time.com Rouleau died from angina pectoris in his episcopal residence, at age 65. He is buried at Notre-Dame de Québec Cathedral.
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The board ceased to function when the Germans occupied rest of France. The secret work took its toll and his angina pectoris got worse over the years. Eventually the Pat Line was betrayed. On 25 February 1943 Rodocanachi was arrested at his home by six Gestapo.
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He died of angina pectoris at his home in Manhattan on April 20, 1923.Staff report (April 21, 1923). Dr. S. S. Wheeler, Inventor, Dead; President of Crocker-Wheeler Co. Dies Suddenly at His Park Av. Home at 63. Engineer and physicist, founder of United Engineering Society.
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Evans died of Angina pectoris, at his London home in Grosvenor Place, on 22 January 1907 aged 66 after a short illness.The Times, 26 January 1907, p. 7. He was buried in Orpington in Kent where he had a home, Tubbendens.The Times, 28 January 1907, p. 8.
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Cardiovascular disease is common in the general population, affecting the majority of adults. It includes: #Coronary heart disease (CHD): Myocardial infarction (MI), angina pectoris, heart failure (HF), and coronary death. #Cerebrovascular disease, stroke and transient ischemic attack (TIA). #Peripheral arterial disease, intermittent claudication and significant limb ischemia.
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He died of angina pectoris on 20 July 1912 at the Tor-na-Coille Hotel in Banchory, Banchory, survived by his wife. He was buried in the cathedral precincts at St Andrews, where a monument can be visited in the south-east corner of the 19th century section.
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He died from heart failure on 23 March 1894, just a couple of weeks after participating in his last meeting of the South London Entomological and Natural History Society where he submitted his final paper for publication. He had been suffering from angina pectoris for a few years.
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Molsidomine (trade names Corvasal, Corvaton and many others) is an orally active, long acting vasodilating drug used to treat angina pectoris. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
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I caught Sir James with his protectoress: The rector’s wife, I mean the rectoress. His heart stood still: angina pectoris, To keep my love alive. Sir Frank brought ladies to my palaces. I poured a mickey in their chalices: While paralyzed, they got paralysis, To keep my love alive.
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During his career, Massumi authored over 200 papers, 130 of which he was senior author, and authoring a chapter in the textbook "Cardiac Arrhythmias" and co-authoring "Complex Electrocardiography". He was a driving force behind the field's understanding of Prinzmetal-Massumi syndrome, a rare form of angina pectoris.
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He was instrumental in establishing the chair of obstetrics at the Irish College of Physicians. He died in 1859 of angina pectoris and buried at Mount Jerome Cemetery in Dublin. Montgomery was married; his great- grandson H. L. Hardy Greer was an obstetrician at the Royal Maternity Hospital in Belfast.
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F15845 is a cardiac drug proposed to have beneficial effects for the treatment of angina pectoris, arrhythmias and ischemia by inhibiting the persistent sodium current. The drug, currently in phase II of clinical trials, targets the persistent sodium current with selectivity and produces minimal adverse effects in current experimental studies.
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He built a hospital for women with 100 beds in Zhenjiang. He named it in honor of his wife, who had been a missionary to that nation. Quine also endowed four schools for girls throughout China, each bearing her name. Quine died in Chicago on December 7, 1922, from angina pectoris.
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Glasgow in 1852. MacKenzie died at Glasgow of angina pectoris on 30 July 1868, leaving a widow and one son. MacKenzie was the mentor of Thomas Wharton Jones, leading to a significant scientific genealogy including physicists such as Paul Dirac and Stephen Hawking. The University of Auckland awards a MacKenzie Medal.
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Hulusi Behçet was deeply interested in the arts, particularly literature. Generally he was nervous and suffered from insomnia, colitis and angina pectoris, but sometimes he was joyful and good humoured among friends. He was divorced from his wife seven years before his death from a sudden heart attack on 8 March 1948.
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The Manchester Guardian of 22 September recorded "On Friday morning the 14th inst. suddenly of angina pectoris, under which he had laboured for some years, Thomas Andrew, Esq, of Harpurhey aged 68. He has left a widow and numerous family to lament his loss." His son George Andrew I reorganised the business.
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Richard Cottell died on 30 August 1911 at his residence in Curlew Street, Toowong, from angina pectoris aged 46 years old. He was buried in Toowong Cemetery on 31 August 1911. His second wife Lily died on 15 April 1942 aged 72 years and was buried with her husband in Toowong Cemetery.
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Murphy died of heart disease in Mackinac Island, Michigan after having been ill for six months. He was staying at the Grand Hotel and was attended by his wife and Drs. L. L. MacArthur and James Keefe. After he suffered from angina pectoris for several years, his death was attributed to aortitis.
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Richardson died suddenly from angina pectoris on 27 October 1918. In December 1918, the Kingston Hosiery Company entered into voluntary liquidation as Richardson was the principal stockholder and his son did not wish to continue the business of the company. James Armstrong Richardson, Sr. became president of James Richardson and Sons in 1919.
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Discussion of the quarrel: Sutcliffe pp. 262-275 Sharp went on to become an authority on folk music and dance. Marson resumed his writing and parish work but died suddenly of ‘angina pectoris’ in March 1914 aged 54. His son, John Charles Marson, was killed, aged 19, at Suvla Bay, Turkey, on 8 August 1915.
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For more than two years he had been a sufferer from angina pectoris, and during a visit to Europe last January he was seriously ill with la grippe and pneumonia, from which he never fully recovered. He died suddenly at his home in Providence, May 12, 1890, in his 46th year. He was unmarried.
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His proposers were Sir William Turner, Andrew Wilson, James Cossar Ewart and Alexander Crum Brown. In 1919 he was created a Knight of the British Empire (KBE) by King George V. He died of angina pectoris at 20 Lennox Road SouthProceedings of the Royal Society of Edinburgh 1930 in Southsea on 19 November 1929.
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Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as a 5-HT1A and 5-HT1B receptor antagonist, used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.
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A nitrovasodilator is a pharmaceutical agent that causes vasodilation (widening of blood vessels) by donation of nitric oxide (NO), and is mostly used for the treatment and prevention of angina pectoris. This group of drugs includes nitrates (esters of nitric acid), which are reduced to NO in the body, as well as some other substances.
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Cardiovascular medical devices are implanted in cases where the heart, its valves, and the rest of the circulatory system is in disorder. They are used to treat conditions such as heart failure, cardiac arrhythmia, ventricular tachycardia, valvular heart disease, angina pectoris, and atherosclerosis. Examples include the artificial heart, artificial heart valve, implantable cardioverter-defibrillator, cardiac pacemaker, and coronary stent.
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Chase suspects breast cancer or angina pectoris, and admits her. Wilson clears the patient of cancer, leaving her shoulder pain without a clear cause. House enters with the team and begins probing why Chase took this particular case. Chase leaves to avoid House's badgering, but not before House surmises that the patient has a fungal infection.
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In his last years, Balanchine suffered from angina pectoris and underwent heart bypass surgery.Man and Microbes, pp. 195-96. After years of illness, Balanchine died on 30 April 1983, aged 79, in Manhattan from Creutzfeldt–Jakob disease, which was diagnosed only after his death. He first showed symptoms during 1978 when he began losing his balance while dancing.
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The approved uses are for the long-term treatment of hypertension and angina pectoris. In hypertension, recent clinical guidelines generally favour diuretics and ACE inhibitors, although calcium channel antagonists, along with thiazide diuretics, are still favoured as primary treatment for patients over 55 and black patients.Hypertension: management of hypertension in adults in primary care. Clinical guideline CG34.
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Stents to maintain the arterial widening are often used at the same time. Coronary bypass surgery involves bypassing constricted arteries with venous grafts. This is much more invasive than angioplasty. The main goals of treatment in angina pectoris are relief of symptoms, slowing progression of the disease, and reduction of future events, especially heart attacks and death.
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Calcium channels are also present in the smooth muscle lining blood vessels. By relaxing the tone of this smooth muscle, calcium channel blockers dilate the blood vessels. This has led to their use in treating high blood pressure and angina pectoris. The pain of angina is caused by a deficit in oxygen supply to the heart.
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Tombs of John Herschel and Charles Darwin. Westminster Abbey In 1882 he was diagnosed with what was called "angina pectoris" which then meant coronary thrombosis and disease of the heart. At the time of his death, the physicians diagnosed "anginal attacks", and "heart-failure". It has been speculated that Darwin may have suffered from chronic Chagas disease.
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Sarpogrelate (brand name Anplag; former developmental code names MCI-9042, LS-187,118) is a drug which acts as an antagonist at the 5HT2A and 5-HT2B receptors. It blocks serotonin-induced platelet aggregation, and has applications in the treatment of many diseases including diabetes mellitus, Buerger's disease, Raynaud's disease, coronary artery disease, angina pectoris, and atherosclerosis.
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By nitration of isosorbide with concentrated nitric acid, 2,5-isosorbide dinitrate (ISDN) can be obtained. 2,5-isosorbide dinitrate is suitable (just like its major metabolite 5-isosorbide mononitrate, ISMNRemington: The Science and Practice of Pharmacy, 21st Edition, p. 1359, edit. D.B. Troy, Lippincott Williams & Wilkins, 2006, .) for the treatment of angina pectoris due to its vasodilator effect.
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Carvey continued to suffer from angina pectoris as a result and successfully sued for $7.5 million in damages. He donated the money to charity. He had to undergo additional surgery to correct his heart problems. He told Newsday that, while he was in the hospital for his final angioplasty, Frank Sinatra died in the room adjacent to his.
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On 28 May 1886, Ostrovsky departed to Schelykovo, feeling already very ill. While staying at an inn he suffered a severe asthma attack. His condition started to quickly deteriorate; he spent his last days in great pain, unable to move. On 2 June Ostrovsky died in his home of angina pectoris while at his desk translating William Shakespeare's Antony and Cleopatra.
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Murabito JM. J Am Med Womens Assoc. 1995 Mar- Apr;50(2):35-9. Along with other important studies about smoking, such as the British Doctors Study, it also confirmed that cigarette smoking is a highly significant factor in the development of heart disease, leading in many cases to angina pectoris, myocardial infarction (MI), and coronary death.The health risks of smoking.
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Due to ill health, Teixeira traveled on a rest cure in 1920 at Crowborough and the Isle of Wight, returning to his home in Chelsea, London in spring 1921. He worked as usual through the autumn and traveled to Cornwall for the winter.McKenna, p. 15. On December 5, 1921, in St Ives, Cornwall he collapsed and died from angina pectoris.
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Rickards died of angina pectoris and chronic myocarditis at his Berkeley, Alameda County, California home on 26 December 1927. His death certificate notes that he was retired from a special appointment to the U.S. Agricultural Secretary.California State Board of Health, Bureau of Vital Statistics, Standard Certificate of Death His cremains are interred at Chapel of the Chimes in Oakland, California.
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Ghika returned to Romania due to an attack of angina pectoris and continued his studies in Romania. Ghika was an alumnus of the College of St. Thomas, the future Pontifical University of St. Thomas Aquinas Angelicum, in Rome. In 1898, he enrolled in the Faculty of Philosophy and Theology. At the Angelicum, Ghika completed a licentiate in Philosophy and a Doctorate in Theology in 1905.
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Cardiac ischemia may be asymptomatic or may cause chest pain, known as angina pectoris. It occurs when the heart muscle, or myocardium, receives insufficient blood flow. This most frequently results from atherosclerosis, which is the long-term accumulation of cholesterol-rich plaques in the coronary arteries. Ischemic heart disease is the most common cause of death in most Western countries and a major cause of hospital admissions.
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Angina, also known as angina pectoris, is chest pain or pressure, usually due to not enough blood flow to the heart muscle. Angina is usually due to obstruction or spasm of the arteries that supply blood to the heart muscle. Other causes include anemia, abnormal heart rhythms and heart failure. The main mechanism of coronary artery obstruction is atherosclerosis as part of coronary artery disease.
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Beckton's death was unexpected, reportedly from "angina pectoris", over the night of 17–18 March 1931 while he was still president of the Royal. He did not marry and was survived by a sister and brother. His collection of philatelic literature of over 900 volumes was donated to the Manchester public library in 1934 where it is still available as the Beckton Philatelic Library.Beckton Philatelic Library.
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Pheniprazine (INN; also known as amphethydrazine and amphetamine hydrazide; brand names Catron and Cavodil) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. It was also used in the treatment of angina pectoris and schizophrenia. Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.
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She and actress Mary Pickford reportedly became good friends. In 1935 she returned to Germany, but left soon thereafter. Back in Hollywood, she dated Gary Cooper for a while but married Russian actor and writer Ivan Lebedeff. After Lebedeff's death in 1953 of angina pectoris, she moved back to Europe, where she stayed with several friends in London and Stockholm before she went back to Germany.
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The phrase does not necessarily connote a fallacy. For example, a patient presents with retrosternal pain which is not relieved by sublingual nitrates (a standard remedy for angina pectoris) but is relieved with antacids (a standard remedy for heartburn). In such a case, a physician may hypothesize ex juvantibus what the underlying problem may or may not be, until a definitive diagnosis is established.
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In 1775, he published a letter to William Heberden on angina pectoris, which contains one of the earliest English reports of a post-mortem examination on a case of that disease. He had noticed calcification of the aortic valves and of the aorta itself. His son, Martin Wall, collected his works into a volume entitled 'Medical Tracts,' which was published at Oxford in 1780.
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Among his scientific publications are The Elements of Bacteriology (1906), About the Angina Pectoris of Malaric Origin (1909) and The Elements of Philosophy (1912). Hernández treated the poor for free and even bought them medicines with his own money. With the arrival of 1918 Spanish flu in Venezuela, Hernández attended the contagious in Caracas. Hernández died in 1919, after being struck by a car.
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His family reports that he began experiencing consistent chest pains around November 12, 1907. On Sunday, November 24, his family physician examined him, finding nothing wrong with Pritchard. He went to work the following day, as usual, but was stricken with acute angina pectoris at home that evening. His physician was called in and morphine was administered, but it took two hours for the pain to subside.
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On 7 October 1931 Ricketts died suddenly, aged 65, from angina pectoris at the Regent's Park house. A memorial service was held at St James's, Piccadilly, on 12 October, after which he was cremated at Golders Green Crematorium;"Mr. Charles Ricketts, R.A.", The Times, 13 October 1931, p. 15 his ashes were partly scattered in Richmond Park, London, and the remainder buried at Arolo, Lake Maggiore, Italy.
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He was a fascist hardliner, and on July 24, 1943, as member of the Gran Consiglio del Fascismo he voted against the Ordine del Giorno Grandi, joining Mussolini's side. In September 1943 he was appointed Italian Social Republic's first Minister of Justice. On October 30, 1943, he died as a result of angina pectoris, and was replaced as Minister of Justice by Piero Pisenti.
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Signs of familial dysbetaproteinemia include xanthoma striatum palmare (orange or yellow discoloration of the palms) and tuberoeruptive xanthomas over the elbows and knees. The disease leads to premature atherosclerosis and therefore a possible early onset of coronary artery disease and peripheral vascular disease leading to a heart attack, i.e. myocardial infarction, chest pain on exercise, i.e. angina pectoris or stroke in young adults or middle aged patients.
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From 1861 he maintained a private practice, and also participated in the Second Schleswig War (1864), Austro-Prussian War (1866) and Franco-Prussian War (1870–71). In 1867 he obtained his habilitation, subsequently serving as director of the Irren-Heil- und Pflege-Anstalt in Greifswald. In 1873 he became an associate professor of psychiatry at Greifswald.NDB/ADB Deutsche Biographie (biography) He died of angina pectoris.
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Intramuscular injections of khellin can also be used to treat asthma. Khellin acts as a bronchodilator; however, the common side effects including nausea present difficulties. Khellin has been used to relieve the pain associated with angina pectoris by acting as a selective coronary vasodilator. This can be done either orally or intramuscularly; however nausea is a major side effect regardless of how the medication is taken.
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"We don't know why some people, but apparently not most, who take large doses may lose their hearing". In 2005, Limbaugh was forced to undergo "tuning" due to an "eye twitch", an apparent side-effect of cochlear implants. On December 30, 2009, while vacationing in Honolulu, Hawaii, Limbaugh was admitted to Queen's Medical Center with intense chest pains. His doctors attributed the pain to angina pectoris.
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In 1926, he became ill with angina pectoris and moved to Yalta, where he worked with Maria to create a museum at Anton's home."The Chekhov House in Yalta" @ Priart. He also collected his own letters, worked as a consultant and catalogued Anton's personal library. In 1929, he became a member of the "" and wrote Вокруг Чехова (On Chekhov), which became known as "Chekhov's Encyclopedia".
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In 2004 he accepted the Grand Prix scientifique de la Fondation Lefoulon-Delalande for clinical investigations of vasomotor function in angina pectoris. He was made Commander of the Order of Merit of the Italian Republic in 1989, and Knight Grand Cross of the Order of Merit of the Italian Republic in 2005. John Paul II appointed him Knight Commander of the Order of St. Gregory the Great.
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Stem bromelain (SBM) (EC 3.4.22.32), a proteolytic enzyme, is a widely accepted phytotherapeutical drug member of the bromelain family of proteolytic enzymes obtained from Ananas comosus. Some of the therapeutic benefits of SBM are reversible inhibition of platelet aggregation, angina pectoris, bronchitis, sinusitis, surgical traumas, thrombophlebitis, pyelonephritis and enhanced absorption of drugs, particularly of antibiotics. Its anti-metastasis and anti-inflammatory activities are apparently independent of its proteolytic activity.
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In 1847, Ascanio Sobrero invented nitroglycerine to treat angina pectoris and it turned out to be a much more powerful explosive than guncotton. It was very dangerous to use until Alfred Nobel found a way to incorporate it in a solid mixture called dynamite and developed a safe detonator. Even then, dynamite needed to be stored carefully or it could form crystals that detonated easily. Thus, the military still preferred guncotton.
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Pindolol is used for hypertension in the United States, Canada, and Europe, and also for angina pectoris outside the United States. When used alone for hypertension, pindolol can significantly lower blood pressure and heart rate, but the evidence base for its use is weak as the number of subjects in published studies is small. In some countries, pindolol is also used for arrhythmias and prophylaxis of acute stress reactions.
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It has been pointed out that many of the positive health effects reported with sauna usage, in particular its cardiovascular benefits, may be non-causal - e.g., sauna users tend to have other habits that are health- promoting. Saunas may not be safe in cases of unstable angina pectoris, recent heart attack, or severe aortic stenosis. Additionally, there is risk of heat prostration, hyperthermia, heat stroke and even death.
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Although a doctor was called, Frank Paton died from heart failure at around 5.30 am on 13 November 1909, just 10 days short of his 54th birthday.From an article about the death of Frank Paton, Essex County Standard, West Suffolk Gazette and Eastern Counties Advertiser, 20 November 1909, page 2. Angina pectoris was recorded as the cause of death on Frank Paton's death certificate, registered 19 November 1909 by his widow.
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As with other triptans, almotriptan should not be used in patients with a history, symptoms or signs of ischaemic heart disease (myocardial infarction, angina pectoris, documented silent ischaemia, Prinzmetal’s angina) or severe hypertension and uncontrolled mild or moderate hypertension. Other contraindications are previous cerebrovascular accident (CVA) or transient ischaemic attack (TIA), peripheral vascular disease, severe hepatic impairment, concomitant administration of ergotamine, ergotamine derivatives (including methysergide) and other 5-HT1B/D agonists.
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AH-1058 displays characteristics of Class IV antiarrhythmics (L-type calcium channel blockers). Class I antiarrhythmic (sodium channel blocker) characteristics have also been seen, but the effect AH-1058 has on sodium channels is variable and unknown. Some proposed uses for AH-1058 include the treatment of angina pectoris, stenosis of the outflow tract from obstructive hypertrophic cardiomyopathy and ventricular arrhythmias.Takahara A, Dohmoto H, Yoshimoto R, et al.
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As of 2003, the top 10 DRGs accounted for almost 30% of acute hospital admissions. In 1991, the top 10 DRGs overall were: normal newborn (vaginal delivery), heart failure, psychoses, Caesarean section, neonate with significant problems, angina pectoris, specific cerebrovascular disorders, pneumonia, and hip/knee replacement. These DRGs comprised nearly 30 percent of all hospital discharges. In terms of geographic variation, as of 2011 hospital payments varied across 441 labor markets.
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The final exhibition of her art was in Rio de Janeiro, Brazil in the same year. She died on 2 September 1909, at her farm in Sintra, of angina pectoris at the age of 68. The Society for the Promotion of Economic Kitchens continued after the Duchess's death and would eventually pass to the control of the Santa Casa da Misericórdia de Lisboa, a Portuguese charity connected to the Catholic Church.
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Diseases affecting cardiac muscle are of immense clinical significance, and are the leading cause of death in developed nations. The most common condition affecting cardiac muscle is ischaemic heart disease, in which the blood supply to the heart is reduced. In ischaemic heart disease, the coronary arteries become narrowed by atherosclerosis. If these narrowings gradually become severe enough to partially restrict blood flow, the syndrome of angina pectoris may occur.
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Returning to his native countryside by 1773, Jenner became a successful family doctor and surgeon, practising on dedicated premises at Berkeley. Jenner and others formed the Fleece Medical Society or Gloucestershire Medical Society, so called because it met in the parlour of the Fleece Inn, Rodborough, Gloucestershire. Members dined together and read papers on medical subjects. Jenner contributed papers on angina pectoris, ophthalmia, and cardiac valvular disease and commented on cowpox.
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It was this multistage test, a description of which was first published in 1963, that became known as the Bruce Protocol. In the initial paper, Bruce reported that the test could detect signs of such conditions as angina pectoris, a previous heart attack, or a ventricular aneurysm. Bruce and his colleagues also demonstrated that exercise testing was useful in screening apparently healthy people for early signs of coronary artery disease.
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The book The Best Remaining Seats by Ben M. Hall (1961), gives a good overview of the movie palaces of the 1920s and, specifically, of Roxy himself. Rothafel had health issues in his later life, mainly angina pectoris. He died of a heart attack in his sleep on January 13, 1936 in New York City aged 53. He is buried in Linden Hill Jewish cemetery in Queens, New York.
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It also showed that cardiovascular risk factors in mid life are significantly associated with increased risk of dementia death later in life. It indicated that cigarette smoking is a highly significant predictor of the development of coronary heart disease, leading to excess rates of angina pectoris, myocardial infarction (MI), and coronary death, along with other studies about smoking, e.g. the Framingham Heart Study and the British Doctors Study.
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The congregation became Unitarian, and later dispersed. On 6 September 1818 Richards was admitted LL.D. by Brown University, but did not live to be aware of the honour. He died at Lynn on 13 September 1818 of angina pectoris, and was buried alongside his wife in the General Baptist Burial Ground at Wisbech. He bequeathed his library of 1300 volumes to Brown University, and left the rest of his property to his sister, Martha Evans.
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Finally, PCI may be used in people with stable angina pectoris, particularly if the symptoms are difficult to control with medication. PCI is an alternative to coronary artery bypass grafting (CABG, often referred to as "bypass surgery"), which bypasses stenotic arteries by grafting vessels from elsewhere in the body. Under certain circumstances such as extensive blockages, background of diabetes, CABG may be superior. Coronary angioplasty was first introduced in 1977 by Andreas Gruentzig in Switzerland.
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However he died the following year at the age of 49 from angina pectoris and was buried in the chapel at Rothley. Parker married Mary Babington, third daughter of Thomas Babington in 1829. Their daughter Susan Emma Parker married Archibald Smith and their son James Parker was a successful rower. Parker was the uncle of Charles Stuart Parker MP. An obituary notice appeared in the issue of Gentleman's Magazine for October, 1852.
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William Heberden (1710–1801), of angina pectoris (chest pain indicative of impaired blood supply to the heart muscle, and an impending heart attack) fame, had a reputation for his diagnostic skills merely through his "expert gaze."Porter R, Porter D. In sickness and in health : the British experience, 1650-1850. New York, NY: B. Blackwell; 1989. Diagnosis depended heavily on the listener's interpretive skills, and treatment relied more on compassion than medicinal chemistry.
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Unstable angina (UA) (also "crescendo angina"; this is a form of acute coronary syndrome) is defined as angina pectoris that changes or worsens. It has at least one of these three features: # it occurs at rest (or with minimal exertion), usually lasting more than 10 minutes # it is severe and of new onset (i.e., within the prior 4–6 weeks) # it occurs with a crescendo pattern (i.e., distinctly more severe, prolonged, or frequent than before).
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In August, he participated in the government panel recommending unconditional acceptance of the Potsdam Declaration. After the surrender of Japan, Wakatsuki was subpoenaed by the Supreme Commander of the Allied Powers in June 1946 as a prosecution witness at The International Military Tribunal for the Far East. Wakatsuki died of Angina pectoris at his summer home in Itō, Shizuoka on November 20, 1949. His grave is at the Somei Cemetery in downtown Tokyo.
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3:451 Sumner's grave in the Granary Burying Ground, Boston, 2009 Sumner never assumed the duties of office after winning the 1799 election as he was sick on his death bed at the time. In order to avoid constitutional issues surrounding the succession to the governor's office, he managed to take the oath of office in early June.Sumner, p. 28 He died in office from angina pectoris, aged 52 on June 7, 1799.
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Oxyfedrine is a vasodilator and a β adrenoreceptor agonist. It was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotropic effects, thereby not precipitating angina pectoris. The latter property (positive chronotropic and inotropic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon. Synergistic effects with antibiotics have been suggested.
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Lord Emmott married Mary Gertrude, a daughter of J. W. Lees, in 1887, and they had two daughters. Lady Emmott was a Justice of the Peace for London. In February 1926, aged 67, Lord Emmott died very suddenly, from angina pectoris, at his home in London, on a day when he was engaged to speak at a Liberal Party rally. The barony became extinct on his death, as he had no son.
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On 26 June 1888, he became prebendary of Brondesbury in St Paul's Cathedral. His final clerical appointment was as Lord Bishop of St Albans on 24 June 1890 and he received a DD degree in the same year. He was President of the Universities' Mission to Central Africa (1892–1902). He was reported to have been seized by angina pectoris in early October 1902, and died two months later on 28 December 1902.
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McWilliams left the Country Party after losing the leadership, and unsuccessfully contested Franklin at the 1925 election as a Nationalist. Running as an independent, he regained Franklin in 1928 and was again successful in 1929, although there was little time for celebration following his second win, because McWilliams died in Hobart from angina pectoris within hours of the declaration of the poll. He was survived by his wife, two daughters and a son.
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The F15845 drug has been developed as a potential drug for therapy of angina pectoris. Current anti-anginal drugs, aiming to prevent ischemic events resulting from angina, fail to completely relieve symptoms without further cardiovascular effects (Vacher et al., 2009). In addition to F15845 being more selective to the persistent sodium current compared to its counterparts, it has also been shown to inhibit ST segment changes in the canine model of angina.
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Pain due to insufficient blood flow to the heart is also called angina pectoris. Those with diabetes or the elderly may have less clear symptoms. Serious and relatively common causes include acute coronary syndrome such as a heart attack (31%), pulmonary embolism (2%), pneumothorax, pericarditis (4%), aortic dissection (1%) and esophageal rupture. Other common causes include gastroesophageal reflux disease (30%), muscle or skeletal pain (28%), pneumonia (2%), shingles (0.5%) and anxiety disorders.
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Jenner's trial balloon descended into Kingscote Park, Gloucestershire, owned by Anthony Kingscote, one of whose daughters was Catherine.Richard B. Fisher, Edward Jenner (Andre Deutsch, 1991) 40–42 He earned his MD from the University of St Andrews in 1792. He is credited with advancing the understanding of angina pectoris. In his correspondence with Heberden, he wrote: "How much the heart must suffer from the coronary arteries not being able to perform their functions".
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However, de Mauny went on to become a successful landscape and gardening designer for many prominent homes in Colombo, authoring, as "Count de Mauny", The Gardens of Tapobane (dedicated to the Duchess of Sutherland) and Gardening in Ceylon. Suffering from angina pectoris, de Mauny died of a heart attack in November 1941. Victor sold Taprobane Island in 1943 for Rs.1200. Lady Mary, aka the Countess de Mauny Tavanade, died in 1947.
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Hydralazine is not used as a primary drug for treating hypertension because it elicits a reflex sympathetic stimulation of the heart (the baroreceptor reflex). The sympathetic stimulation may increase heart rate and cardiac output, and in people with coronary artery disease may cause angina pectoris or myocardial infarction. Hydralazine may also increase plasma renin concentration, resulting in fluid retention. To prevent these undesirable side effects, hydralazine is usually prescribed in combination with a beta blocker (e.g.
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William Heberden, who was also a classical scholar, published several papers in the Philosophical Transactions of the Royal Society; and among his noteworthy contributions to the Medical Transactions (issued, largely at his suggestion, by the College of Physicians) were papers on chickenpox (1767) and angina pectoris (1768). His Commentarii de morborum historia et curatione, the result of notes made in his pocket-book at the bedside of his patients, were published in 1802 and again in 1807.
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He realised the importance of electrocardiography, and published on arrhythmias, particularly ventricular tachycardia. He described a type of aortic stenosis which was not rheumatic in origin, and described effort syncope in the condition. He studied angina pectoris, describing the syndrome in Les Angines de Poitrine in 1925; he maintained the belief that coronary artery disease was the cause. He founded an independent school of cardiology in Lyon at a time when Louis Henri Vaquez dominated cardiology in France.
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The degree of Doctor of Divinity was conferred on him by his Alma Mater in 1884. In 1879 he was attacked with angina pectoris, and sought rest by a long visit to the United States. In 1886 there was a return of the disease, which was thenceforward kept in control by constant watchfulness. Special exertion at the end of December, 1888, brought on another series of attacks, and his death followed on February 1, in his 70th year.
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In 1971, angina pectoris forced Stone to cease publication of the Weekly. After his retirement, he returned to the University of Pennsylvania, where he had dropped out years before. He earned a bachelor's degree in classical Languages. Stone successfully learned Ancient Greek and wrote a book about the prosecution and death of Socrates, The Trial of Socrates, in which he argued that Socrates wanted to be sentenced to death in order to shame Athenian democracy, which he despised.
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New York Red Book (1914; pg. 151; names opponent erroneously "Henry Weyman") Karpen was a member of the 137th New York State Legislature in 1914. In November 1914, he ran for re-election, but was defeated by Democrat Isaac Mendelsohn. Karpen died on July 27, 1936, at the home of his brother Clarence Alfred Karpen in Lynbrook, Nassau County, New York, of angina pectoris; and was buried at the Cypress Hills Cemetery in New York City.
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During World War I he served at the 1st Western General Hospital, becoming a lieutenant-colonel in the Royal Army Medical Corps. He was elected a Fellow of the Royal College of Physicians in 1915 and in 1923 delivered their Bradshaw Lecture on Prognosis in Angina Pectoris. In 1924 he was appointed Professor of Medicine (part-time) at the University of Liverpool. He retired to live at Bowness in the Lake District, where he died in 1959.
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At higher doses, it also dilates arteries, thereby reducing afterload (decreasing the pressure against which the heart must pump). Improved myocardial oxygen demand vs oxygen delivery ratio leads to the following therapeutic effects during episodes of angina pectoris: subsiding of chest pain, decrease of blood pressure, increase of heart rate, and orthostatic hypotension. Patients experiencing angina when doing certain physical activities can often prevent symptoms by taking nitroglycerin 5 to 10 minutes before the activity. Overdoses may generate methemoglobinemia.
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In September 1958, Power and his wife Deborah went to Madrid and Valdespartera, Spain, to film the epic Solomon and Sheba, to be directed by King Vidor, co-starring Gina Lollobrigida. Power had filmed about 75 percent of his scenes when he was stricken by a massive heart attack while filming a dueling scene with his frequent co-star and friend, George Sanders. A doctor, Juan Olaguíbel, diagnosed Power's death as "fulminant angina pectoris."Canales, Luiz (2006).
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Abscesses usually cause throbbing pain. The apical abscess usually occurs after pulp necrosis, the pericoronal abscess is usually associated with acute pericoronitis of a lower wisdom tooth, and periodontal abscesses usually represent a complication of chronic periodontitis (gum disease). Less commonly, non-dental conditions can cause toothache, such as maxillary sinusitis, which can cause pain in the upper back teeth, or angina pectoris, which can cause pain in the lower teeth. Correct diagnosis can sometimes be challenging.
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Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent, research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease). The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested the drug had little effect on angina, but it could induce marked penile erections.
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Another daughter, Gwendolyn Maud Syrie (1879 – 1955), known as Syrie like her mother, was married to wealthy businessman Henry Wellcome, and later to the writer Somerset Maugham, and became a socially prominent London interior designer. Barnardo died of angina pectoris in London on 19 September 1905, and was buried in front of Cairns House, Barkingside, Essex. The house is now the head office of the children's charity he founded, Barnardo's. A memorial stands outside Cairn's House.
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In 1917 Kossel was summoned by the government to pronounce that the allotted food provisions were sufficient. He refused this demand, would never declare untruths as truths Through his marriage to Luise, Kossel was related to several prominent Americans, including soil science pioneer Eugene W. Hilgard, journalist and financier Henry Villard, and abolitionist William Lloyd Garrison. Luise Kossel died in 1913 of acute pancreatitis. Kossel died quietly on 5 July 1927, after a recurring attack of angina pectoris.
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Nadolol is used to treat hypertension and for long-term treatment of angina pectoris and is approved by the FDA for these purposes.Nadolol entry in AccessMedicine. McGraw-Hill Global Education Holdings, LLC. Accessed 8 November 2014 It is regularly used off-label for control of heart rate in people with atrial fibrillation, prevention of migraine headaches; prevention of bleeding veins in people with portal hypertension caused by cirrhosis; and to treat people with high levels of thyroid hormone.
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On the morning of 4 August 1920 he was found dead in his bed by his orderly. The cause of his death was recorded as angina pectoris. He was accorded a military funeral and interred at Maitland Cemetery in Cape Town. Austin Roberts edited Roberts Birds of South Africa in 1940 and Our South African Birds in 1941, and it is readily apparent that the illustrations in these books are copies of the Finch-Davies plates held by the Transvaal Museum.
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He encouraged actors and writers to acknowledge the "use of a power manifestly greater in modern society than it ever was before in the history of civilization... and, if possible, to exert a beneficial influence on the mind of the rising generation, -- the generation that will support the Drama, determine its spirit, and shape its destiny" . He died in New Brighton, Staten Island on June 30, 1917 after a bout of angina pectoris. He was buried at Silver Mount Cemetery.
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Eletriptan is contraindicated in patients with various diseases of the heart and circulatory system, such as angina pectoris, severe hypertension, and heart failure, as well as in patients that have had a stroke or heart attack. This is due to the unusual side effect of coronary vasoconstriction due to serotonin 5HT1B antagonism, which can precipitate a heart attack in those already at risk. It is also contraindicated in severe renal or hepatic impairment due to its extensive liver metabolism through CYP3A4.
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Jehan's gravesite at the Gizri Graveyard near the Saudi Consulate in Karachi Jehan suffered from chest pains in 1986 on a tour of North America and was diagnosed with angina pectoris after which she underwent bypass surgery. In 2000, Jehan was hospitalised in Karachi and suffered a heart attack. On 23 December 2000 (night of 27 Ramadan), Jehan died as a result of heart failure. Her funeral took place at Jamia Masjid Sultan, Karachi and was attended by over 400,000 people.
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They had five kids together, and raised Ed's four children from his previous marriage as well, filling their house with eleven in all. Margaret was a member of the United Church in Chapel Hill, but her children were not devout, although they all attended the Baptist Sunday School irregularly. Ed died in August 1938 due to diabetes and angina pectoris which he came down with in 1936. A pension of about $10.00 a month was sent to the family after Ed's death.
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Dr. William Heberden is credited with being the first to describe in a 1768 publication the occurrence of chest pain attacks (i.e. angina pectoris) that appeared due to pathologically occluded coronary arteries. These attacks were triggered by exercise or other forms of exertion and relieved by rest and nitroglycerin. In 1959, Dr. Myron Prinzmetal described a type of angina that differed from the classic cases of Heberden angina in that it commonly occurred in the absence of exercise or exertion.
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Like other dihydropyridines, lercanidipine is contraindicated in unstable angina pectoris, uncontrolled cardiac failure, shortly after a myocardial infarction, and in patients with left ventricular outflow tract obstruction. It is also contraindicated during pregnancy and in women who may become pregnant, because data regarding safety for the unborn are lacking, as well as in patients with severe liver and renal impairment. The drug must not be combined with strong inhibitors of the liver enzyme CYP3A4 or with the immunosuppressant drug ciclosporin.
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Roosevelt, a chain-smoker throughout his entire adult life, had been in declining physical health since at least 1940. In March 1944, shortly after his 62nd birthday, he underwent testing at Bethesda Hospital and was found to have high blood pressure, atherosclerosis, coronary artery disease causing angina pectoris, and congestive heart failure. Hospital physicians and two outside specialists ordered Roosevelt to rest. His personal physician, Admiral Ross McIntire, created a daily schedule that banned business guests for lunch and incorporated two hours of rest each day.
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JTV-519 (K201) is a 1,4-benzothiazepine derivative that interacts with many cellular targets. It has many structural similarities to diltiazem, a Ca2+ channel blocker used for treatment of hypertension, angina pectoris and some types of arrhythmias. JTV-519 acts in the sarcoplasmic reticulum (SR) of cardiac myocytes by binding to and stabilizing the ryanodine receptor (RyR2) in its closed state. It can be used in the treatment of cardiac arrhythmias, heart failure, catecholaminergic polymorphic ventricular tachycardia (CPVT) and store overload-induced Ca2+ release (SOICR).
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People with coronary artery disease might have just one or two plaques, or might have dozens distributed throughout their coronary arteries. A more severe form is chronic total occlusion (CTO) when a coronary artery is completely obstructed for more than 3 months. Cardiac syndrome X is chest pain (angina pectoris) and chest discomfort in people who do not show signs of blockages in the larger coronary arteries of their hearts when an angiogram (coronary angiogram) is being performed. The exact cause of cardiac syndrome X is unknown.
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Sadegh-Zadeh considers medical language an ill-structured and ill-kept extension of everyday language by adding technical terms such as "angina pectoris", "appendicitis", etc. Sadegh-Zadeh claims that most of its terms are imprecise and ambiguous because they are either undefined or ill-defined.Cf. Chapter 2 and page 822 of the above-mentioned Handbook. Since it has a significant impact both on medical knowledge and medical decision-making, he devotes himself extensively to the analysis of its nature and of its syntax, semantics, and pragmatics.
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These findings were soon to be a foundation for further research into drug development. In the early 1960s, James Black, a Scottish pharmacologist, and associates of his at the Imperial Chemical Industries (ICI) in Great Britain were working on a series of β-adrenergic blocking compounds, pronethalol and propranolol. Dr. Black focused on developing a drug that would relieve the pain of angina pectoris, which results from oxygen deprivation in the heart. His plan was to create a drug that would decrease the heart's requirement for oxygen.
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Mibefradil (Posicor) was a drug used for the treatment of hypertension and chronic angina pectoris. It is a nonselective calcium channel blocker. It was voluntary pulled from the market 10 months after FDA approval, citing potential serious health hazards shown in post release studies. The mechanism of action of mibefradil is characterized by the selective blockade of transient, low-voltage-activated (T-type) calcium channels over long-lasting, high-voltage-activated (L-type) calcium channels, which is probably responsible for many of its unique properties.
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Subkulture's Eternal Death Wake (EDW) Music Festival, known as The Eastern Goth Valley, is an annual Halloween music gathering held every October in the Philippines. It is the first goth festival in the Philippines and has been featured in Japan's counterculture magazine Burst as well as various TV programs. The EDW event has also hosted foreign artists such as the Angina Pectoris (Germany), Eve of Destiny (Japan), Kozi (Japan), Roughhausen (Canada and Taiwan ), DJ Eiji (Japan), Haruhiko Ash (Japan), DJ Nekrokael (France), and Psydoll (Japan).
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Compounds such as levetiracetam, lamotrigine, and carbamazepine are known to block the P-type channels, which have helped to decrease the occurrence of seizures. Overall, there are various non-selective calcium channel blockers that help alleviate symptoms of hypertension, schizophrenia, cardiac arrhythmia, epilepsy, pain, asthma, bradycardia, angina pectoris and Alzheimer's disease. Although many of the therapeutic compounds' main target is not P-type channels, further research needs to determine if the clinical effects of these compounds are also influenced by the P-type channel blockage.
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He suffered from paralysis of the right hand from 1958, and was hospitalized for Angina pectoris in 1960. Tanizaki's characters are often driven by obsessive erotic desires. In one of his last novels, Futen Rojin Nikki (Diary of a Mad Old Man, 1961–1962), the aged diarist is struck down by a stroke brought on by an excess of sexual excitement. He records both his past desires and his current efforts to bribe his daughter-in-law to provide sexual titillation in return for Western baubles.
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Amiodarone was initially developed in 1961 at the Labaz company, Belgium, by chemists Tondeur and Binon, who were working on preparations derived from khellin. It became popular in Europe as a treatment for angina pectoris. As a doctoral candidate at Oxford University, Bramah Singh determined that amiodarone and sotalol had antiarrhythmic properties and belonged to a new class of antiarrhythmic agents (what would become the class III antiarrhythmic agents). Today the mechanisms of action of amiodarone and sotalol have been investigated in more detail.
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He was elected Fellow of the Royal Society on 7 June 1883, and in the same year was nominated by the Crown a member of the General Council of Medical Education and Registration. Duncan's practice became large, and his standing in his profession high. In 1890 his health began to fail, and he did not finish his usual course of lectures. He went abroad in July, and after several attacks of angina pectoris he died at Baden-Baden in Germany on 1 September 1890.
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He lived his final years at 9 Chester Street in Edinburgh's fashionable West End.Edinburgh Post Office Directory 1875 He died suddenly, of angina pectoris, on 18 July 1876. Russel was noted as a conversationalist as well as a writer, but not as a public speaker, and he declined in 1872 an invitation to become a candidate for the lord-rectorship of Aberdeen. His monument (a huge red granite obelisk by Stewart McGlashan) forms the centrepiece of the north section of Dean Cemetery in Edinburgh.
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Discomfort caused by coronary artery disease can radiate to the neck, lower jaw and teeth Non-dental causes of toothache are much less common as compared with dental causes. In a toothache of neurovascular origin, pain is reported in the teeth in conjunction with a migraine. Local and distant structures (such as ear, brain, carotid artery, or heart) can also refer pain to the teeth. Other non-dental causes of toothache include myofascial pain (muscle pain) and angina pectoris (which classically refers pain to the lower jaw).
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Assersen became a lieutenant, captain and in 1889, rear admiral in the United States Navy. Assersen was the chief engineer of Brooklyn Navy Yard and the Norfolk Navy Yard, specializing in building drydocks.U.S. Navy Officers: 1798-1900 (Naval Historical Center) He retired from military service on January 5, 1901, with the rank of rear admiral, and continued on active duty. He died of angina pectoris December 6, 1906Peter C. Asserson - Certificate of death and was buried at the United States Naval Academy in Annapolis.
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Precautions are needed when using NRT in people who have had a myocardial infarction within two weeks, a serious or worsening angina pectoris, and/or a serious underlying arrhythmia. Using nicotine products during cancer treatment is counterrecommended, as nicotine promotes tumour growth, but temporary use of NRTs to quit smoking may be advised for harm reduction. Nicotine gum is contraindicated in individuals with temporomandibular joint disease. People with chronic nasal disorders and severe reactive airway disease require additional precautions when using nicotine nasal sprays.
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Physician introduces pain-relief patch; The Sunday Star Ledger, New Jersey, USA, June 4, 1995. Another US product (Lidoderm) that is based on the same conception is approved for postherpetic pain. Transdermal beta-blockers, including the first time clinical proof in hypertension (with W. Vetter, University of Zurich, H. Vetter, University of Bonn, W. Zidek, University of Münster (1987) and in Angina pectoris (with J. Bonelli, F. Gazo, University of Vienna (1988). Some technical basics and an actualized synopsis of these new findings have been published in a special volume of 'Drug Research' (1989).
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Glycerol is used to produce nitroglycerin, which is an essential ingredient of various explosives such as dynamite, gelignite, and propellants like cordite. Reliance on soap-making to supply co-product glycerol made it difficult to increase production to meet wartime demand. Hence, synthetic glycerol processes were national defense priorities in the days leading up to World War II. Nitroglycerin, also known as glyceryl trinitrate (GTN) is commonly used to relieve angina pectoris, taken in the form of sub-lingual tablets, or as an aerosol spray. An oxidation of glycerol affords mesoxalic acid.
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Patients with aortic regurgitation may experience heart failure symptoms, such as dyspnea on exertion, orthopnea and paroxysmal nocturnal dyspnea, palpitations, and angina pectoris. In acute cases patients may experience cyanosis and circulatory shock. Medical signs of aortic regurgitation include increased pulse pressure by increased systolic and decreased diastolic blood pressure, but these findings may not be significant if acute. The patient may have a diastolic decrescendo murmur best heard at left sternal border, water hammer pulse, Austin Flint murmur, and a displaced apex beat down and to the left.
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Dr. James Black went on to create another β-blocker, called propranolol; a non-selective β-blocker. Clinical trials started in the summer of 1964 and a year later, propranolol was launched under the trade name Inderal, only two and a half years after it had first been tested. It turned out to have a higher potency than pronethalol, with fewer side effects. Propranolol became the first major drug in the treatment of angina pectoris, since the introduction of coronary vasodilators, (such as nitroglycerin), almost 100 years earlier.
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Following a chalk-talk performance in Moncton, New Brunswick in 1922, Bengough suffered an attack of angina pectoris, attributed to overwork during a previous tour of Western Canada. He died of it on 2 October 1923 at his drawing board at his home on 58 St Mary Street in Toronto while working on a cartoon in support of an anti-smoking campaign. At his memorial service on 22 November, the editor of the Hamilton Herald, Albert E. S. Smythe, declared him the "Canadian Dickens" and one of Walt Whitman's "great companions".
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Oxprenolol (brand names Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non- selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure. Oxprenolol is a lipophilic beta blocker which passes the blood–brain barrier more easily than water-soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than beta blockers with more hydrophilic molecules such as atenolol, sotalol and nadolol.
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Casino owner Charley Enley Kyng (Clark Gable) is advised by his physician to slow down, after being diagnosed with angina pectoris, a heart disease. Charley supports his own family as well as his wife's sister, Alice (Audrey Totter) and her husband, Robbin (Wendell Corey). Charley quits drinking and smoking and vows to spend more time with his wife and son. Brother-in-law Robbin, a dealer at Charley's casino, cannot pay a $2,000 gambling debt he owes to a gangster, who sends his goons Lew Debretti (Richard Rober) and Frank Sistina (William Conrad) after him.
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It is shock-sensitive and burns with a clean flame producing water vapor, carbon monoxide, and nitrogen gas. :C3H6(ONO2)2 → 3 CO + 3 H2O + N2 The principal current use of propylene glycol dinitrate is as a propellant in Otto Fuel II, together with 2-nitrodiphenylamine and dibutyl sebacate. Otto Fuel II is used in some torpedoes as a propellant. Nitrates of polyhydric alcohols, of which propylene glycol dinitrate is an example, have been used in medicine for the treatment of angina pectoris, and as explosives since the mid-nineteenth century.
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The pathophysiology of unstable angina is controversial. Until recently, unstable angina was assumed to be angina pectoris caused by disruption of an atherosclerotic plaque with partial thrombosis and possibly embolization or vasospasm leading to myocardial ischemia. However, sensitive troponin assays reveal rise of cardiac troponin in the bloodstream with episodes of even mild myocardial ischemia. Since unstable angina is assumed to occur in the setting of acute myocardial ischemia without troponin release, the concept of unstable angina is being questioned with some calling for retiring the term altogether.
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Fearful that local employees would control what he was allowed to see, he sent an assistant to visit each site and provide him with a complete report on it two weeks in advance of his arrival. The tour was interrupted in August, when President Wilson asked his Interior Secretary to go to Denver and serve as his representative at the Conference of Governors. Lane did, and then rejoined his inspection party in San Francisco. After several days of meetings there, he collapsed because of an attack of angina pectoris.
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The sublingual region underneath the front of the tongue is an ideal location for the administration of certain medications into the body. The oral mucosa is very thin underneath the tongue, and is underlain by a plexus of veins. The sublingual route takes advantage of the highly vascular quality of the oral cavity, and allows for the speedy application of medication into the cardiovascular system, bypassing the gastrointestinal tract. This is the only convenient and efficacious route of administration (apart from Intravenous therapy) of nitroglycerin to a patient suffering chest pain from angina pectoris.
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Circulation 2002;106:1913-8. although such studies have been found to contain discrepancies. It has been reported that improvement in heart contractility has occurred as a result of the induction of angiogenesis.Kastrup, J. Jorgensen E, Ruck A, Tagil K, Glogar D, Ruzyllo W, Botker HE, Dudek D, Drvota V, Hesse B, Thuesen L, Blomberg P, Gyongyosi M and Sylven C. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris: A randomized double-blind placebo-controlled study: the Euroinject One Trial.
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He was a director in numerous corporations, including the Equitable Trust Co. of New York and the Union Pacific Railroad. During the last years of Kahn's life he became increasingly frail and suffered from arteriosclerosis, high blood pressure and attacks of angina pectoris. On March 29, 1934, following lunch in the private dining room of Kuhn, Loeb & Co., Kahn suffered a massive heart attack and died, aged 67. Funeral services were held in the music room of his Long Island estate, followed by a burial in nearby St. John's Memorial Cemetery.
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His treatise states clearly the relation between albuminuria and dropsy, and shows that he suspected that the kidneys were diseased in these cases. The further discovery of Richard Bright in 1836 of the constant relation between renal disease and albuminuria is based upon the observations first made by Blackall. Blackall also published in 1813 some observations on angina pectoris, a disease then much discussed, owing to William Heberden's writings upon it. Blackall was admitted candidate of the Royal College of Physicians on 22 December 1814, and a fellow on 22 December 1815.
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In his seventy-fourth year Day insisted on resigning, but was immediately elected a member of the Corporation, in which office he served until a month before his death, which occurred just after the completion of his ninety-fourth year. In 1835, Day had been urged to become head of Andover Theological Seminary, but had declined. Never strong, and after 1836 subject to attacks of angina pectoris, Day prolonged his life by self-knowledge and moderation in all things. He was a man of dignity and extreme reserve.
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Accelerated deposition of cholesterol in the walls of arteries leads to atherosclerosis, the underlying cause of cardiovascular disease. The most common problem in FH is the development of coronary artery disease (atherosclerosis of the coronary arteries that supply the heart) at a much younger age than would be expected in the general population. This may lead to angina pectoris (chest pain or tightness on exertion) or heart attacks. Less commonly, arteries of the brain are affected; this may lead to transient ischemic attacks (brief episodes of weakness on one side of the body or inability to talk) or occasionally stroke.
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Although a public supporter of the regime, Petrolini did not refrain from satire, including a famously disrespectful rejoinder after Mussolini had presented him with a medal. Forced to quit the stage in 1935 following a severe attack of angina pectoris, he died aged 52, in Rome, on 29 June 1936. The corpse, dressed in a tailcoat of his celebrated character Gastone, was buried at the Cemetery of Verano. On 19 July 1943, during the first bombing of Rome, his tomba rectangular chapelwas hit, breaking the marble bust and severely damaging the coffin containing the remains of the actor.
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The lingual veins begin on the dorsum, sides, and under surface of the tongue, and, passing backward along the course of the lingual artery, end in the internal jugular vein. The vena comitans of the hypoglossal nerve (ranine vein), a branch of considerable size, begins below the tip of the tongue, and may join the lingual; generally, however, it passes backward on the hyoglossus, and joins the common facial. The lingual veins are important clinically as they are capable of rapid absorption of drugs; for this reason, nitroglycerin is given under the tongue to patients suspected of having angina pectoris.
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This is based on the Frank-Starling law of the heart. Healthy patients should be able to compensate for lower volumes to some extent, but patients with pre-existing cardiovascular disease limiting myocardial function (such as angina pectoris) may not. Applying permissive hypotension to the latter patient category may result in decreased coronary perfusion and result in ischemic damage to the heart and potentially myocardial infarction (heart attack). Permissive hypotension may also be contraindicated in patients with cerebrovascular disease, carotid artery stenosis, and compromised renal (kidney) function, where hypotension may induce sludge (thickening of blood) and lead to occlusion of the vessel lumen.
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Three years later he founded the influential Mackenzie Institute of Clinical Research in St Andrews, which involved local General Practitioners in detailed long-term recording of patients' symptoms and illnesses. Ironically Mackenzie himself suffered from an irregular heart beat, as a result of ischemic heart disease. He had his first heart attack in 1901, and recorded in himself the atrial fibrillation that accompanied this episode. By 1907 Mackenzie experienced frequent episodes of angina pectoris which he mentioned to Sir Thomas Lewis and in 1908 he had a severe episode of cardiac pain, probably due to a myocardial infarction.
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INN) or dichloroisoproterenol (USAN), abbreviated DCI — the first β-blocker to be developed. β adrenergic receptor antagonists (also called beta-blockers or β-blockers) were initially developed in the 1960s, for the treatment of angina pectoris but are now also used for hypertension, congestive heart failure and certain arrhythmias. In the 1950s, dichloroisoproterenol (DCI) was discovered to be a β-antagonist that blocked the effects of sympathomimetic amines on bronchodilation, uterine relaxation and heart stimulation. Although DCI had no clinical utility, a change in the compound did provide a clinical candidate, pronethalol, which was introduced in 1962.
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In addition to receiving the Nobel Prize in Physiology or Medicine for the discovery of nitric oxide as a new cellular signal—shared in 1998 with Louis Ignarro and Ferid Murad Furchgott's discovery, that NO gas causes blood vessels to dilate, provided a long sought-after explanation for the therapeutic effects of Nitroglycerin used to treat Angina pectoris and was later instrumental in the development of the erectile dysfunction treatment drug Viagra.BBC News vom 23. Mai 2009: US „Viagra scientist“ dies at 92. In 1991, Furchgott received a Gairdner Foundation International Award for his groundbreaking discoveries.
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Following Thomas Brunton's discovery that amyl nitrite could be used to treat chest pain, William Murrell experimented with the use of nitroglycerin to alleviate angina pectoris and reduce blood pressure, and showed that the accompanying headaches occurred as a result of overdose. Murrell began treating patients with small doses of GTN in 1878, and the substance was widely adopted after he published his results in The Lancet in 1879. The medical establishment used the name "glyceryl trinitrate" or "trinitrin" to avoid alarming patients, because of a general awareness that nitroglycerin was explosive. Overdoses may generate methemoglobinemia.
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The French chemist Antoine Jérôme Balard synthesized amyl nitrite in 1844. Sir Thomas Lauder Brunton, a Scottish physician born in the year of amyl nitrite's first synthesis, documented its clinical use to treat angina pectoris in 1867 when patients experiencing chest pains would experience complete relief after inhalation. Brunton was inspired by earlier work with the same agent, performed by Arthur Gamgee and Benjamin Ward Richardson. Brunton reasoned that the angina sufferer's pain and discomfort could be reduced by administering amyl nitrite—to dilate the coronary arteries of patients, thus improving blood flow to the heart muscle.
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These drugs have opened up new perspectives for the > treatment of angina pectoris, cardiac irregularities and hypertension. More > recently, in a concerted drive carried out with great vision, he has > developed a new type of histamine antagonist capable of inhibiting gastric > acid secretion induced by histamine or pentagastrin. Apart from its > practical implications this work has considerable fundamental importance > since it provided evidence for the existence of a new type of histamine > receptor. This work has also provided experimental support for the > hypothesis that endogenous histamine may be involved in the secretion of > acid in the stomach.
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Underwood and Rhodes state that the early forms of traditional Indian medicine identified fever, cough, consumption, diarrhea, dropsy, abscesses, seizures, tumours, and leprosy, and that treatments included plastic surgery, lithotomy, tonsillectomy, couching (a form of cataract surgery), puncturing to release fluids in the abdomen, extraction of foreign bodies, treatment of anal fistulas, treating fractures, amputations, cesarean sections, and stitching of wounds. The use of herbs and surgical instruments became widespread.Underwood & Rhodes (2008) During this period, treatments were also prescribed for complex ailments, including angina pectoris, diabetes, hypertension, and stones. (Republished by National Informatics Centre, Government of India.)Lock et al.
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Nitroglycerin belongs to a group of drugs called nitrates, which includes many other nitrates like isosorbide dinitrate (Isordil) and isosorbide mononitrate (Imdur, Ismo, Monoket). These agents all exert their effect by being converted to nitric oxide in the body by mitochondrial aldehyde dehydrogenase (ALDH2), and nitric oxide is a potent natural vasodilator. Nitroglycerin in three different forms: intravenous, sublingual spray, and the nitroglycerin patch. In medicine, nitroglycerin is used for angina pectoris, a painful symptom of ischemic heart disease caused by inadequate flow of blood and oxygen to the heart and as a potent antihypertensive agent.
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Nitroglycerin is a major component in double-based smokeless gunpowders used by reloaders. Combined with nitrocellulose, hundreds of powder combinations are used by rifle, pistol, and shotgun reloaders. In medicine for over 130 years, nitroglycerin has been used as a potent vasodilator (dilation of the vascular system) to treat heart conditions, such as angina pectoris and chronic heart failure. Though it was previously known that these beneficial effects are due to nitroglycerin being converted to nitric oxide, a potent venodilator, the enzyme for this conversion was not discovered to be mitochondrial aldehyde dehydrogenase (ALDH2) until 2002.
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Toothache may be caused by dental (odontogenic) conditions (such as those involving the dentin-pulp complex or periodontium), or by non-dental (non-odontogenic) conditions (such as maxillary sinusitis or angina pectoris). There are many possible non-dental causes, but the vast majority of toothache is dental in origin. Both the pulp and periodontal ligament have nociceptors (pain receptors), but the pulp lacks proprioceptors (motion or position receptors) and mechanoreceptors (mechanical pressure receptors). Consequently, pain originating from the dentin-pulp complex tends to be poorly localized, whereas pain from the periodontal ligament will typically be well localized, although not always.
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American Communist Party leader William Z. Foster (1881-1961) suffered from a serious heart ailment ever since symptoms of angina pectoris began to first appear on the campaign trail in June 1932.Edward P. Johanningsmeier, Forging American Communism: The Life of William Z. Foster. Princeton, NJ: Princeton University Press, 1994; pg. 266. An exhausting travel schedule that took him 30,000 miles and place him before more than 100 crowds — events which included arrests in Los Angeles and Lawrence, Massachusetts — exacerbated Foster's existing health condition. On September 8, 1932, Foster collapsed from a severe heart attack in Moline, Illinois which nearly claimed Foster's life.
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He was a member and a vestryman of St. Paul's church, and was one of the trustees of the Young Men's Christian Association of Burlington, and one of its most liberal supporters. Few men, if any, touched the life of the community in which he lived in so many important capacities. His sudden death from angina pectoris in New York City removed, while in the prime of life, a most genial, courteous and kind-hearted man, a gallant soldier, and one of the most respected citizens of the Green Mountain state. Burlington effectively shut down for his funeral.
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Side effects of the tablet form in conjunction with levodopa include, in decreasing order of frequency, nausea, hallucinations, confusion, depression, loss of balance, insomnia, increased involuntary movements, agitation, slow or irregular heart rate, delusions, hypertension, new or increased angina pectoris, and syncope. Most of the side effects are due to a high dopamine signaling, and can be alleviated by reducing the dose of levodopa. The main side effects of the patch form for depression include application-site reactions, insomnia, diarrhea, and sore throat. The selegiline patch carries a black box warning about a possible increased risk of suicide, especially for young people, as do all antidepressants since 2007.
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In 1896, Procter secured the release of the positions of chief clerks and chiefs of divisions from the spoils system and had them filled by promotions or transfers from within the classified service. Procter served as a member of the Jury of Awards at the Chicago World's Fair, and was a frequent contributor to magazines and journals on geologic, economic, international and political subjects. He was a member of the Century Club of New York City. He died of angina pectoris while at the Cosmos Club in Washington, D. C., where he was attending the annual meeting of the National Civil Service Reform League.
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A surprised Ramazzotti appealed to the pope to rethink the appointment but his pleas were ignored. Official news on 22 August 1861 revealed that Ramazzotti would be promoted to the cardinalate on 27 September 1861 and when he heard he attempted to dissuade Pope Pius IX from the elevation due to his poor health - he suffered from angina pectoris. He also made an appeal to Cardinal Giacomo Antonelli on the grounds on his financial condition that he could not afford the expenses for the cardinalate. Angelo Ramazzotti died on 24 September 1861 in Crespano del Grappa where he had gone in order to recover from his ailments.
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John Stuart McCaig (sometimes styled as John Stuart McCaig of Muckairn and Soroba) was the second son of Malcom [sic] McCaig (a farmer) and Margaret Stewart and was born at Clachan, Isle of Lismore, Argyll, Scotland on 11 July 1823 and baptised at St Moluag's Cathedral, Lismore. He died aged 78 from Angina Pectoris, on 29 June 1902 at John Square House,National Library of Scotland 1867 Townplan of Oban (Zoomed on John Square) Oban, Argyll. He is principally known for commissioning McCaig's Tower in Oban for which he was also the architect. He had extensive dealings within the Oban surroundings including being the Gas Works Director and owning the Pier.
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Unstable angina (UA), also called crescendo angina, is a type of angina pectoris that is irregular. It is also classified as a type of acute coronary syndrome (ACS). It can be difficult to distinguish unstable angina from non-ST elevation (non-Q wave) myocardial infarction (NSTEMI). They differ primarily in whether the ischemia is severe enough to cause sufficient damage to the heart's muscular cells to release detectable quantities of a marker of injury (typically troponin T or troponin I). Unstable angina is considered to be present in patients with ischemic symptoms suggestive of an ACS and no elevation in troponin, with or without ECG changes indicative of ischemia (e.g.
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Black then became Professor of Analytical Pharmacology at the Rayne Institute of King's College London medical school, where he remained until 1992. He established the James Black Foundation in 1988 with funding from Johnson & Johnson and led a team of 25 scientists in drugs research, including work on gastrin inhibitors which can prevent some stomach cancers. Black contributed to basic scientific and clinical knowledge in cardiology, both as a physician and as a basic scientist. His invention of propranolol, the beta adrenergic receptor antagonist that revolutionised the medical management of angina pectoris, is considered to be one of the most important contributions to clinical medicine and pharmacology of the 20th century.
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The cranium dysfunction mechanical changes in the gut can compress the vagus nerve at any number of locations along the vagus, slowing the heart. As the heart slows, autonomic reflexes are triggered to increase blood pressure and heart rate. This is complemented by gastro-coronary reflexes whereby the coronary arteries constrict with "functional cardiovascular symptoms" similar to chest-pain on the left side and radiation to the left shoulder, dyspnea, sweating, up to angina pectoris -like attacks with extrasystoles, drop of blood pressure, and tachycardia (high heart beat) or sinus bradycardia (heart beat below 60). Typically, there are no changes / abnormalities related in the EKG detected.
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Interest in a medical role for inorganic nitrite was first aroused because of the spectacular success of organic nitrites and related compounds in the treatment of angina pectoris. While working with Butter at the Edinburgh Royal Infirmary in the 1860s, Brunton noted that the pain of angina could be lessened by venesection and wrongly concluded that the pain must be due to elevated blood pressure. As a treatment for angina, the reduction of circulating blood by venesection was inconvenient. Therefore, he decided to try the effect on a patient of inhaling amyl nitrite, a recently synthesized compound and one that his colleague had shown lowered blood pressure in animals.
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Referred pain, also called reflective pain, is pain perceived at a location other than the site of the painful stimulus. An example is the case of angina pectoris brought on by a myocardial infarction (heart attack), where pain is often felt in the neck, shoulders, and back rather than in the thorax (chest), the site of the injury. The International Association for the Study of Pain has not officially defined the term; hence several authors have defined it differently. Radiating pain is slightly different from referred pain; for example, the pain related to a myocardial infarction could either be referred or radiating pain from the chest.
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While bivouacked at Puckapunyal Camp, Victoria, he died suddenly of coronary heart disease on 13 June 1941. The medical officer attending later concluded: "The cause of death in my opinion was angina pectoris, the fatal attack having been brought on by physical exertion during a night exercise under very cold conditions." He was cremated on 16 June at Eastern Suburbs Crematorium, Sydney, after a full military funeral, and his ashes were interred at Woronora Cemetery, Sydney. Wark's Victoria Cross is part of the collections of the Queensland Museum, South Bank, but was loaned to the Australian War Memorial from February 2017 for temporary display in the latter's Hall of Valour during the centenary period of the First World War.
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Calcium channel blockers are also frequently used to alter heart rate (especially from atrial fibrillation), to prevent peripheral and cerebral vasospasm, and to reduce chest pain caused by angina pectoris. N-type, L-type, and T-type voltage-dependent calcium channels are present in the zona glomerulosa of the human adrenal gland, and CCBs can directly influence the biosynthesis of aldosterone in adrenocortical cells, with consequent impact on the clinical treatment of hypertension with these agents. CCBs have been shown to be slightly more effective than beta blockers at lowering cardiovascular mortality, but they are associated with more side effects. Potential major risks however were mainly found to be associated with short-acting CCBs.
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The 1894 novella The Rabbit Warren about a clergyman who'd been honoured for reporting people to the authorities and driving a police official into madness by his zealousness (one of "his most remarkable works and his greatest achievement in concentrated satire," according to Mirsky) was also banned and came out only in 1917 (in Niva magazine). The process of having his works published, which had always been difficult for Leskov, at this late stage became, in his own words, "quite unbearable". In his last years Leskov suffered from angina pectoris and asthma. There were also rumours, whose accuracy and substantiation have been questioned, that he had been diagnosed with male breast cancer.
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Symptoms of aortic stenosis may include heart failure symptoms, such as dyspnea on exertion (most frequent symptomVOC=VITIUM ORGANICUM CORDIS, a compendium of the Department of Cardiology at Uppsala Academic Hospital. By Per Kvidal September 1999, with revision by Erik Björklund May 2008), orthopnea and paroxysmal nocturnal dyspneaChapter 1: Diseases of the Cardiovascular system > Section: Valvular Heart Disease in: , angina pectoris, and syncope, usually exertional. Medical signs of aortic stenosis include pulsus parvus et tardus, that is, diminished and delayed carotid pulse, fourth heart sound, decreased A2 sound, sustained apex beat, precordial thrill. Auscultation may reveal a systolic murmur of a harsh crescendo-decrescendo type, heard in 2nd right intercostal space and radiating to the carotid arteries.
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Medical costs were a significant issue brought up by Margaret O’Neal in the interview for the Federal Writers' Project. The family had to take much of their savings and spend them on doctor's visits for birthing costs, a nurse for a child, and even for visiting Duke University Hospital. For each of the five boys that Margaret and Ed had together, they had to bring in a doctor for $30 a visit, and for the last child had to hire a nurse for three weeks at a total expense of $45. As for Ed, he had to visit the Duke University Hospital twice, the first time being diagnosed with diabetes, and the second time with angina pectoris.
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Zolmitriptan should not be given to patients with ischemic heart disease (angina pectoris, history of myocardial infarction, or documented silent ischemia) or to patients who have symptoms or findings consistent with ischemic heart disease, coronary artery vasospasm, including Prinzmetal's angina, or other significant underlying cardiovascular disease. Zolmitriptan may increase blood pressure, it should not be given to patients with uncontrolled hypertension, should not be used within 24 hours of treatment with another 5-HT1 agonist, or an ergotamine-containing or ergot-type medication like dihydroergotamine or methysergide, and should not be administered to patients with hemiplegic or basilar migraine. Concurrent administration of MAOI or use of zolmitriptan within 2 weeks of discontinuation of MAO-A inhibitor therapy is contraindicated.
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Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which was used as a vasodilator in the treatment of angina pectoris; it was introduced in the 1960s by German manufacturer Albert-Roussel pharma gmbh which was acquired by Hoechst AG in 1974 and which in turn became part of Sanofi Aventis in 2005. It was withdrawn from market worldwide in 1988 because it caused QT prolongation and Torsades de pointes which in turn caused sudden death. The cardiac side effects were not detected during clinical development, but only emerged after the drug was widely used. Prenylamine has two primary molecular target in human, Calmodulin and Myosin light-chain kinase 2 found in skeletal and cardiac muscle.
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Renal angina is a clinical methodology to risk stratify patients for the development of persistent and severe acute kidney injury (AKI). The composite of risk factors and early signs of injury for AKI, renal angina is used as a clinical adjunct to help optimize the use of novel AKI biomarker testing. The term angina from Latin (“infection of the throat”) and from the Greek ẚnkhone (“strangling”) are utilized in the context of AKI to denote the development of injury and the choking off of kidney function. Unlike angina pectoris, commonly caused due to ischemia of the heart muscle secondary to coronary artery occlusion or vasospasm, renal angina carries no obvious physical symptomatology (i.e.
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172 His active participation in the conflict ended abruptly after only a month and a half: on July 25, 1940, Paladini came down with angina pectoris and had to leave his command, replaced by Admiral Angelo Iachino. In September 1940 he returned to the command of the Naval Academy; during this period, in 1942, he was promoted to Ammiraglio di Squadra designato d'armata. On 12 September 1942 he was placed in auxiliary due to age limits, but he was immediately recalled to service, always as the commander of the Naval Academy; in January 1943 he was promoted to Ammiraglio d'Armata (Admiral). He suddenly died in Livorno on March 19, 1943, due to heart problems.
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Pauling directed research on vitamin C, but also continued his theoretical work in chemistry and physics until his death. In his last years, he became especially interested in the possible role of vitamin C in preventing atherosclerosis and published three case reports on the use of lysine and vitamin C to relieve angina pectoris. During the 1990s, Pauling put forward a comprehensive plan for the treatment of heart disease using lysine and vitamin C. In 1996, a website was created expounding Pauling's treatment which it referred to as Pauling Therapy. Proponents of Pauling Therapy believe that heart disease can be treated and even cured using only lysine and Vitamin C and without drugs or heart operations.
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Ryan, Earl Browder, pg. 53. The third member of the Secretariat, William Z. Foster, the party's candidate for President, suffered an attack of angina pectoris and was ordered by doctors to cease campaigning and to undergo bed rest — with visitation and dictation similarly proscribed.Ryan, Earl Browder, pg. 53. With Foster out of the picture and a big majority of the party leadership backing him over Weinstone, Browder appealed to the Comintern to resolve what he called "impossible relations" with Weinstone by assigning one of them for Comintern work abroad.Ryan, Earl Browder, pg. 54. On November 13, 1932, after extensive debate, the Comintern ruled in Browder's favor, determining that Weinstone would be removed from America to once again serve in Moscow as the CPUSA's official representative there.
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Angina pectoris can be quite painful, but many patients with angina complain of chest discomfort rather than actual pain: the discomfort is usually described as a pressure, heaviness, tightness, squeezing, burning, or choking sensation. Apart from chest discomfort, anginal pains may also be experienced in the epigastrium (upper central abdomen), back, neck area, jaw, or shoulders. This is explained by the concept of referred pain, and is due to the fact that the spinal level that receives visceral sensation from the heart simultaneously receives cutaneous sensation from parts of the skin specified by that spinal nerve's dermatome, without an ability to discriminate the two. Typical locations for referred pain are arms (often inner left arm), shoulders, and neck into the jaw.
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Born on 15 April 1860 into a family of newspaper proprietors, Benham was educated at Colchester Royal Grammar School but did not attend university. He later returned to the school to become President of the Old Colcestrian Society for old boys of the school. Living in Colchester for all but a handful of years of his life spent with Mebrose printers in Derby \- and, in turn, writing about it in many of his books - he helped edit the family-controlled paper the Essex County Standard jointly with his brother William Gurney Benham from 1892 until his death in 1929, which was described as "sudden and unexpected," from angina pectoris whilst in his editorial office for the newspaper. He left a widow.
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For the Philadelphia Exhibition (1876) Morel-Ladeuil produced "A Pompeian Lady at her Toilet," following it in 1878 with the "Bunyan Shield," a companion to the Milton. After putting forth his reliefs "The Merry Wives of Windsor," "The Merchant of Venice," and "Much Ado about Nothing," in view of his failing health he retired to Boulogne, where he died of angina pectoris on 15 March 1888. He was buried with much ceremony at Clermont-Ferrand. His total work, apart from the productions of his youth, numbers 35 pieces, which richly reveal his elegant and refined fancy and grace, his feeling for correct and dainty ornament, and his love of pure art marked by an elevated if rather sentimental taste and a noble style.
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In 2016, he played the minister of commerce in Josef Cedar's Norman: The Moderate Rise and Tragic Fall of a New York Fixer. In 2018 he played a holocaust survivor in the Austrian film:"Murer: Anatomie eines Prozesses", in the critically acclaimed mini-series "Stockholm", in Yankul Goldwasser's film "Laces" for which he won the Israeli Academy award for best actor in a supporting role, and in Yonathan Indurski's and Ori Alon series "The Conductor" opposite Lior Ashkenazi. Since 2016, he had been starring in the theatrical political comedy "Angina Pectoris", written by Michal Aharoni, in the leading role. In 2018/2019 he played Etgar in Burkhard C. Kosminski's highly acclaimed production of "Vögel" by Wajdi Mouawad at Schauspielhaus Stuttgart.
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Richardson worked for the Library of Congress as a consultant without compensation until 1934, at which point several conflicts and his unwillingness to compromise demanded his resignation from the Library of Congress, the American Library Association in 1934, the American Library Institute in 1935 and the Institut Francais de Washington in 1936. Richardson’s wife, Grace, died on October 29, 1933, following which he rented their home in Princeton and resided mainly in their cottage “High Pastures” in Old Lyme, Connecticut. He began to collapse and disperse his personal library, approximately 15,000 volumes, to the Library of Congress, the Army Medical Library and the Brick Row Bookshop in New York City. On June 29, 1939 Richardson died of angina pectoris, and was buried in the Ely family plot near Lyme, Connecticut.
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He was suffering angina pectoris as well as severe pain in his hands and shoulders from bone degeneration, and he may have developed diabetes. In this state, Eisler tried to earn a living with a scattering of essays and lectures and occasional employment as a financial consultant or tutor. For extra money and when his health allowed, he sometimes worked stoking the boiler in his building. He applied for funding for a series of lectures on the fourth gospel from The Hibbert Trust, a Unitarian endowment that offered grants to those seeking to “contribute to the education, knowledge or understanding of Unitarianism or liberal religion.” It was denied, prompting him to angrily accuse the board of bias against non- Christians. In 1942 Eisler proposed to the BBC a broadcast reading of his reconstruction of Ecclesiastes for Ash Wednesday.
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The manufacturer, Rio Chemicals of St. Louis was clear to differentiate the inclusion of true unicorn rather than false unicorn in its preparation. The earliest versions did contain drugs that are still in use today for the same purposes, for example digitalis for heart failure;, salicylates for headache rheumatism and fever, nitroglycerin for cardiac angina pectoris;, and bismuth salicylate for diarrhea Merck also began publishing Merck’s Archives of the Materia Medica, a monthly journal consisting of papers related to drugs and uses, which was available for an annual subscription of US $1.00. Ad for the January 1906 edition of the Merck's Archives The second edition of The Merck Manual was published in 1901, was expanded to 282 pages and included new sections on poisons and antidotes, tables and conversion charts, and a detailed explanation of the metric system.
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After some graduate study at Yale Medical School, he entered early in 1865 the U. S. Navy as Acting Assistant Surgeon, but the speedy close of the American Civil War led to his resignation, in October of the same year. In 1866 he entered on active practice as a physician and surgeon in Bridgeport, and was thus engaged, with growing reputation and success, especially in obstetrical cases, until his death. He was also a member of the City Board of Health for many years, for twelve years a member of the Board of Education, and in 1882 served as representative in the Connecticut General Assembly. For two years before his death he suffered at times intensely from neuralgia of the chest; he died very suddenly, it was supposed from angina pectoris, at his home, November 9, 1884, aged 46.
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Named after its inventor, Otto Reitlinger, Otto Fuel II consists of the nitrated ester explosive propellant propylene glycol dinitrate (PGDN), to which a desensitizer (dibutyl sebacate) and a stabilizer (2-nitrodiphenylamine) have been added. The chief component, propylene glycol dinitrate, accounts for approximately 76% of the mixture, while dibutyl sebacate and 2-nitrodiphenylamine account for approximately 22.5% and 1.5% (by weight), respectively. The principal current use of propylene glycol dinitrate is as a propellant in Otto Fuel II. Nitrates of polyhydric alcohols such as this have been used in medicine for the treatment of angina pectoris, and as explosives since the mid-nineteenth century. In addition to its use by the United States Navy as a stabilizer in the manufacture of Otto Fuel II, 2-nitrodiphenylamine is employed for similar purposes by the United States Army in the manufacture of double base solid propellants.
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The patent creating him Baron Leighton, of Stretton in the County of Shropshire, was issued on 24 January 1896; Leighton died the next day of angina pectoris. Cimabue's Celebrated Madonna is carried in Procession through the Streets of Florence, 1853–1855 Daphnephoria, oil on canvas painting, 1874–1876, Lady Lever Art Gallery Leighton remained a bachelor; rumours of him having an illegitimate child with one of his models, in addition to the supposition that Leighton may have been a homosexual, continue to be debated.Emanuel Cooper, The Sexual Perspective: Homosexuality and Art in the Last 100 Years in the West, 2005 He certainly enjoyed an intense and romantically tinged relationship with the poet Henry William Greville whom he met in Florence in 1856.Oxford Dictionary of National Biography vol 33 The older man showered Leighton in letters, but the romantic affection seems not to have been reciprocated.
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As a consequence, lateral compression of the coronary artery leads to coronary luminal (inside opening) narrowing, with reduced supply of blood and oxygen to the depending myocardial tissue, that is phasic (worse in systole, the phase of cardiac contraction, and tachycardia). Furthermore, the intramural segment of the ectopic artery, located inside the aorta, is typically but variably “hypoplastic”, smaller in circumference than the distal, extramural segments (it is unable to grow properly either before or after birth). Autonomic and/or endothelial dysfunction may occur and induce spasm and/or thrombosis at anomalous sites (and critical ischemia), although intracoronary clotting has been rarely observed. Therefore, stenosis of an intramural proximal segment, lateral compression and spastic hyperreactivity are the mechanisms that have been linked to clinical manifestation. Coronary narrowing is most likely the main process implied in ACAOS, and it may result in symptoms such as chest pain (“angina pectoris”), dyspnea (shortness of breath), palpitations, cardiac arrhythmias (heart rhythm disorders), syncope (fainting).
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Narrowings of the coronary arteries (ischaemic heart disease) are treated to relieve symptoms of chest pain caused by a partially narrowed artery (angina pectoris), to minimise heart muscle damage when an artery is completely occluded (myocardial infarction), or to prevent a myocardial infarction from occurring. Medications to improve angina symptoms include nitroglycerin, beta blockers, and calcium channel blockers, while preventative treatments include antiplatelets such as aspirin and statins, lifestyle measures such as stopping smoking and weight loss, and treatment of risk factors such as high blood pressure and diabetes. In addition to using medications, narrowed heart arteries can be treated by expanding the narrowings or redirecting the flow of blood to bypass an obstruction. This may be performed using a percutaneous coronary intervention, during which narrowings can be expanded by passing small balloon-tipped wires into the coronary arteries, inflating the balloon to expand the narrowing, and sometimes leaving behind a metal scaffold known as a stent to keep the artery open.
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In August 1940 Iachino was given command of the 2nd Naval Squadron (consisting of the 1st, 3rd and 7th Naval Divisions), with flag on the heavy cruiser Pola, after its previous commander, Admiral Riccardo Paladini, came down with angina pectoris. In this role, he participated on 27 November 1940 in the Battle of Cape Spartivento. On 9 December 1940 he replaced Admiral Inigo Campioni as commander of the entire battle fleet of the Regia Marina, with flag on the battleship Vittorio Veneto. On 9 February 1941, Iachino led the Italian fleet in the unsuccessful pursuit of the British Force H, after the latter had bombarded Genoa and La Spezia. He again commanded the Italian battle fleet in the Battle of Cape Matapan (26-29 March 1941), which resulted in the biggest defeat ever suffered by the Regia Marina; dismissing reports of nearby British battleships as incorrect or exaggerated, he sent the entire 1st Cruiser Division to the rescue of the stricken cruiser Pola, resulting in the annihilation of the entire Division by the three battleships of Admiral Andrew Browne Cunningham's Mediterranean Fleet.
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De Langen's main contribution is the discovery of the association between a diet low in cholesterol, fat and meat and very low incidence of gallstones, cardiovascular disease. He wrote: > “The question has frequently been asked whether cholesterol concentration of > blood and bile is controlled by diet—the diet of the population in the Dutch > East Indies differs very much from the Western European diet. The local diet > is mainly vegetarian with rice as the staple, that is very poor in > cholesterol and other lipids.” (quoted in ) In his report to the second Conference of the International Society of Geographic Pathology in 1934 he noted that only 1 case of angina pectoris had been observed among Javanese patients admitted to the 500 bed Municipal Hospital in Batavia in five years. In his textbook, Clinical textbook of tropical medicine, he stated that: > “The food of the masses which visit our hospitals and polyclinics in Java > contains but little cholesterin; the result is a smaller content of > cholesterin in the blood.
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