On our advice, the replication team in Denver generated and pilot-tested a new list of famous figures to use in its replication study.
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When I was approached to help with a replication, my collaborators and I not only sent our research materials to the researchers on the replication team; we also shared an important insight: They would have to completely change the research stimuli to run the replication.
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The story of the replication crisis got a bit more complicated last week when a group of psychologists out of Harvard published a critique of the replication project, also in Science.
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The answer is she had a replication error, said Brawley.
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This period has been called the "replication crisis" by some.
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But no direct evidence of this replication was ever found.
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Economics, like other social sciences, is suffering a replication crisis.
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But once it awakens, its quick replication could become deadly.
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Here's a replication of the chart from that 2013 speech.
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"The redundancy and replication will ensure it'll never be lost."
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First, scientists have very few incentives to even try replication.
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The new paper isn't an exact replication of the original.
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"Keep in mind it's a mathematical simulation, it's not a clinical trial, but [Vogelstein is] noting that a certain number of cases are due to replication error, DNA replication error, in normal growth," said Brawley.
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Kowalczykowski compared DNA replication to driving on a congested California freeway.
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One is that the experimenters doing the replication messed something up.
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This commitment to feature replication extends to the wheels as well.
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Replication, it seems, is a whole lot murkier than we thought.
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It's also important to remember: Replication issues aren't limited to psychology.
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This applies both to replication and playing the violin in public.
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Scientists face few incentives to engage in the slog of replication.
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That's exactly where you get this problem of replication of bias.
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Education right now, he says, is a form of data replication.
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It also blocked virus replication in monkeys for a different coronavirus.
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She walked Ms. Irgit through each step of the replication process.
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Science Times at 40 Science is mired in a "replication" crisis.
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Not long afterward, Riken announced that its replication efforts had failed.
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Replication can stop unpredictably, and speeds can vary by about ten-fold.
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Replication is, of course, one of the fundamental tenets of good science.
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Ultimately, this "replication crisis," as it's being called, is a good thing.
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The color replication is great, and yes, the black is very black.
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Existing drugs control viral replication, but cannot affect dormant, integrated viral genes.
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One worrying possibility was that those mutations somehow sped up Ebola's replication.
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That, however, hasn't stopped Zuckerberg from signing off on other replication projects.
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Pimodivir works by targeting and inhibiting part of the virus replication process.
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But Josh Kline's work makes it impractical to privilege rehabilitation over replication.
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Many psychological theories have been debunked or diminished in rigorous replication attempts.
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They've been answering that question by embarking on large-scale replication efforts.
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After all, one of the OSC's original findings was that, since there's no standard in place for what a study replication should look like, there's no way of agreeing upon what it means when a replication is unsuccessful.
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But there's a big wrinkle with replication studies: They don't work like that.
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In this case, Ganglioside GMI was responsible for triggering infectious replication and transmission.
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DAAs target proteins found in the virus, inhibiting or interfering with its replication.
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Current HIV treatment cannot eliminate the virus entirely but does suppress its replication.
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While single mutations had successfully inhibited viral replication, others actually conferred unexpected resistance.
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Finally, Google's managed NoSQL database service Cloud Bigtable now supports multi-region replication.
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In Singapore, the office features a replication of the city's colorful shophouse windows.
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China can do quick and cheap replication of existing products to make money.
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Some of our respondents suggested that scientists engage in replication prior to publication.
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A similar replication effort in economic papers found 60 percent of findings replicated.
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Remarkable moments of interplay between repetition, replication, delay, and decay run throughout Strata.
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Peer review contains all sorts of implicit biases; replication is spotty at best.
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The second set came from a survey by the National Comorbidity Survey–Replication.
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But we've never viewed that our platform should just be a replication of this.
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He further showed that this statistical tendency to dissipate energy might foster self-replication.
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Genes lead a simple life; replication is both their purpose and their raison d'etre.
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But replication results do often significantly change the story we tell about the experiment.
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But it is by far the most accurate replication of human handwriting to date.
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"[Replication projects are] shining a light on the way we conduct research," Errington said.
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"We will need to wait for a replication of the fMRI results," Sharot said.
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And to be clear, a failed replication doesn't mean the original study is wrong.
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But there's mounting, if at times contentious, evidence that science has a replication problem.
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Around that time, the largest replication project in the history of psychology was underway.
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Scientists need more carrots to entice them to pursue replication in the first place.
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Replication is important to scientists, because it means the finding might just be real.
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In an attempt at replication, we're likely to see something much closer to zero.
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The critical tests of peer review and replication ensure that the consensus is sound.
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Nitrosamines are genotoxic, meaning they affect DNA replication and possibly cause cancer, Woodcock explained.
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It was already known that when cells replicate their DNA, the replication mechanism sometimes stalls.
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Like other psychologists, she is concerned about the so-called replication crisis in her field.
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Nosek, the replication project leader, said that scientists used to be defensive about his efforts.
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Some focus on absolute replication, while others play with abstract ideas and science fiction fantasy.
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The meta-analysis worried Hagger and his colleagues, so they launched their multinational replication attempt.
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"This seems like a space where replication is crucial," Emily Oster wrote in an email.
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Opinions vary, of course, but no one disputes that the act of replication is important.
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The company uses high-performance liquid chromatography to parse the chemistry of wines for replication.
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A successful replication would boost the reputation of the lab that published the original result.
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And a culture of openness and replication means that scientists are policed by their peers.
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The goal is to enable granular control of replication by geography at the column level.
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That could allow future missions to simply include replication units to print whatever you need.
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In the interest of transparency, we have posted all data to this website for replication.
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Meanwhile, nearly half of the studies (333) had never been subject to replication at all.
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All art forms rooted in the performers' physicality struggle to perfectly translate via technological replication.
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They are, however, extremely good at replication and creating things in a particular artistic style.
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While science-t involves only first-order concerns about properly structured experiments, evidence, replication, etc.
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Or it could be that a treatment is slowing down the coronavirus's self-replication spree.
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Repetition is difficult in this business and the replication of past success stories is impossible.
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Replication attempts at the Stanford prison study, on the other hand, have been a mess.
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Scientists at the University of California, Davis, captured DNA replication on video for the first time.
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The past few years have seen many psychological phenomena destroyed or diminished in rigorous replication attempts.
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The missing piece, of course, is the careful, rigorous, prospective studies with the validation and replication.
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They include Betsy Sparrow, a former psychologist at Columbia University, who disagrees with the replication methods.
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Josh Nicholson, Scite's co-founder, says he hopes the system incentivizes greater replication of original findings.
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This is the first time we have replication for this kind of prevention tool in women.
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Interpreting the results of a replication study is another place where things can get messy, fast.
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But with each replication, small variations creep into the sequence at particular locations on the genome.
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In the world of financial technology, simple replication of the proven Western winners does not work.
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Some viral proteins disrupt the replication of attacking viruses, leaving them unable to invade other cells.
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On Thursday, Science also published a strong rebuttal from the authors of the original replication project.
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"We want to see if the vaccine prevents illness and replication of the virus," Clarke said.
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In the wake of Ranehill's failed replication, Cuddy and Carney set to work on a response.
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The replication crisis in science is often presented as an issue of scientific procedure or integrity.
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This is sometimes referred to as psychology's "replication crisis," and it came for oxytocin research too.
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Clearly, an expansive food program at schools like Harding Senior High bears replication nationwide, not cutbacks.
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And they point out that there are important differences between their study and the replication trials.
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We're doing that in a current study, a replication of that with a more elaborate study.
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I've talked to a lot of researchers who are interested in replication, and reevaluating past work.
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To teach the "replication crisis" is to teach students that science strives to be self-correcting.
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Replication has emerged as a powerful tool to check science and get us closer to the truth.
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The point of this replication project, and others like it, is not to call out individual researchers.
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The Palmyra arch will be its first replication, landing this April in Times Square and Trafalgar Square.
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The experiments showed that CRISPR/Cas9 could severely block virus replication for herpes simplex and human cytomegalovirus.
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Often, though, replication does not get done as thoroughly as it should be—or even at all.
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Behind the replication movement is an earnest desire to be more transparent and humble about scientific conclusions.
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But he thinks these studies may need more outside replication and statistical analysis to confirm the results.
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In smaller quantities, these vitamins are involved in several vital processes in the body, including DNA replication.
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Characteristically, her thought proceeds by way of verbal fission and replication: She shifts on the substandard bed.
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Then they can set their sights on understanding why the replication results differed from the original study.
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"Everywhere about me, I can see beautiful militants hell-bent on regeneration, not self-replication," she writes.
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Journals are also reluctant to publish replication studies unless "they contradict earlier findings or conclusions," Allem writes.
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That essentially made this newer study a replication of the original — one that contradicted the previous findings.
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They conducted the replication study of psychological research, and are now doing similar work in cancer research.
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That would raise biosafety issues: Is it "replication competent" — is there any chance of shedding and spreading?
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A few weeks after the session with Kline, I attended an official meeting of the replication committee.
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Publication bias is often cited as a major factor in the so-called replication crisis in research.
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This was true in even the most punitive version of the model, in which labs received a penalty 100 times the value of the original "pay-off" for a result that failed to replicate, and replication rates were high (half of all results were subject to replication efforts).
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Nguyen and Huntley sat in a pumpkin patch for their replication of "It's The Great Pumpkin, Charlie Brown."
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Both treatments aim to halt flu replication in the human body but target different parts of its cycle.
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"We didn't want to do a one-for-one replication," Charles Yust, frog's principal design technologist, told Mashable.
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The only major feature you're not getting for free (besides support) is support for replication and Kerberos Authentication.
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For external replication purposes, a dataset of 17,000 celebrity photos, containing 100,000 images, was scraped from the web.
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In Baltimore: In 2007, Baltimore implemented the program Safe Streets, which was the first Cure Violence replication site.
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These are issues that experts have been debating since well before the original replication study appeared last August.
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If the infected cells kill themselves, then there's fewer chances for replication of the viruses that infect them.
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The Senate usually requests a response (called a replication) from the managers to the answer of the impeached.
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In 2015, researchers reported on their replication of 100 experiments published in 2008 in three prominent psychology journals.
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In the absence of replication it does not mean much and is most likely a false positive finding.
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If it isn't the same ship—if restoration has crossed into replication—which piece of timber was decisive?
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At the head of the replication committee is Carol Mancusi-Ungaro, who also leads the Whitney's conservation department.
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Then the phages disperse and if they come into contact with other bacteria they repeat the replication process.
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The drug worked by slowing down the speed of virus replication, and in some cases kept it from spreading.
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And to be fair, a power pose replication test did find that participants felt a subjective sense of power.
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The scientists who ran the 21 replication tests didn't just repeat the original experiments — they made them more rigorous.
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And part of the tedious process of doing a scene like that is, you have to do crowd replication.
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It achieves up time through replication, so if one version of itself goes down, the next can take over.
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When the DNA unwinds in preparation for replication and cell division, the legs of the DNA ladder are broken.
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Scientists have known for decades that HIV infection persists even when viral replication is effectively controlled by antiretroviral therapy.
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It's not a trope until it becomes one, and it becomes one through repetition and a replication of it.
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Replication would have been quick and easy if the problem was with the chip board and designs, he said.
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In 2012, social priming — an influential theory that explains how subliminal cues influence our behavior — failed a replication test.
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We oppose the replication and expansion of risk-based systems that have exacerbated current racial disparities in immigration enforcement.
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A lot of things drive the replication crisis, but the endless race for funding is certainly one of them.
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Self-replication certainly seems like an insufficient rationale for adding a person to the planet in its present state.
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Replication would have been quick and easy if the problem was with the chip board and designs, he said.
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They don't favor hearing about hypotheses that didn't pan out or replication studies that upset a previously published claim.
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Supporters cloak this requirement in the seemingly innocuous argument that replication of research is a central tenet of science.
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It's a study that needs careful replication; the analysis was designed to suggest a hypothesis, not to prove it.
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Long before social media made things like bib replication easier, banditing at major races was viewed as a brave act.
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It is extremely on the nose — as in, it's a weird not-quite-accurate replication of the iconic Hollywood sign.
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The form follows function, which in this case, means infiltrating the cells of a host and hijacking their replication machinery.
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At the hospital, Meredith (Ellen Pompeo) is doing a presentation of her liver replication project for the Catherine Fox Foundation.
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It is hoped that the success of this withdrawal will lead the way for future preservation and replication projects elsewhere.
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We believe that many lessons have been learned and that replication will be a far less painful process going forward.
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But—and here's an article-carrying but—a kickdrum—bear with me here—is essentially a replication of the heartbeat.
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Prices start a $0.90 per node per hour (which includes replication) and storage will cost $0.30 per GB per month.
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Fortunately, the iconic building became such an amalgam of design across the centuries that restoration need not mean exact replication.
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HIV, for example, starts out with a burst of viral replication before the immune system is alerted to its presence.
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The authors state that a replication study with another large group of people would be needed to confirm their results.
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I wrote a piece highlighting Blum's exposé and putting the prison experiment in the larger context of psychology's replication crisis.
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Arguably the game's worst offense is its replication of several sections in the Parthenon frieze on random buildings and pedestals.
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A (not perfectly representative) recent survey of 262 psychology professors found more than half said replication issues impacted their teaching.
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The Center for Open Science's replication efforts have inspired economists and even tropical ecologists to plan reproducibility projects of their own.
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For a field coming somewhat late to the replication crisis party, it's ironic that economics identified its own credibility issues early.
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During IRL filming, everything has to be painstakingly marked, choreographed, and tracked to perfectly match up with the green-screen replication.
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The "fittest" are those that turned out to be better at survival and replication, but you can't predict what fitness entails.
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Perhaps the most well-known paper tackled by the replication researchers was about how online access to information shapes people's minds.
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"Antiretrovirals suppress HIV replication, but they aren't able to clear the virus-infected cells that remain hidden," Bar said by email.
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These sorts of experiments are really controversial right now with the replication crisis, so I don't want to overstate the significance.
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Arena is not just a replication of the card game Magic: The Gathering in the same way that Magic Online is.
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While some minor differences popped up in each replication, a few major discrepancies between the original and redone studies stood out.
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"There would need to be a few more of these massive replication failures to support a claim like that," he says.
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This means they can ionize our poor DNA nucleotides , ripping them apart and occasionally leading to uncontrollable replication errors (aka, cancer).
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The idea is that these programs could "serve as models for national replication" if they prove successful on a small scale.
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Viruses steal a cell's nucleotides to make more copies of itself, using a special enzyme as their engine of self-replication.
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With support from The John A. Hartford Foundation, pilot care models across the country with replication potential are empowering family caregivers.
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Had he looked, he would have been annoyed to see that Cuddy did not include a mention of the Ranehill replication.
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Such individual experimentation is not the same thing as the scientific method; it lacks the proving tests of replication and consensus.
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Thirty percent of respondents trended toward ideas of meritocracy and another 34% believed in a combination of meritocracy and social replication.
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Replication is often absent or woefully inadequate; theories are often driven by hype and media attention; peer review is often weak.
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"The result of this form of replication across cities is the wholesale denial of the very idea of locality," says Picardi.
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A lot of my work lately has been about replication, or duplicates, and the uncanny being experiencing something more than once.
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The meticulous replication of some of scenes from his movie and TV work, moreover, is a bit of a nostalgic kick.
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NWN was, at the time, full of promise, and he credits this replication of the pen-and-paper player-DM relationship.
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Beyond that, avoiding replication of a lot of research, development, and testing was supposed to save another big chunk of change.
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""With all studies, we need replication of the findings in different populations to solidify our conclusions concerning the veracity of the findings.
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One of Samsung's latest "me too" features may be a replication of Apple's 3D Touch on the iPhone 6s and 73s Plus.
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In this context, a recent attempted replication is important, for it actually was published last week in a journal called Psychological Science.
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And increasingly scientists are realizing that if a replication fails to reproduce the original results, it doesn't mean the original was wrong.
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The paper was led by Harvard psychologist Daniel Gilbert (you'll recognize him from Prudential commercials), who has generally challenged the replication movement.
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In the case of Alluxio's enterprise product, these additional features include better support for high-availability setups, enterprise security and data replication.
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These mutations happen as the father gets older and his sperm continues to reproduce, creating more opportunities for error in DNA replication.
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This quantum algorithm simulated major biological processes such as self-replication, mutation, interaction between individuals, and death at the level of qubits.
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The effects of some studies could not be reproduced, it seems, because the replication studies were not actually studying the same thing.
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Each time a cell divides, the replication process can't copy all of our DNA, and a little gets missed from the ends.
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Nosek has detailed other potential fixes that might help with replication — all part of his work at the Center for Open Science.
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But the night is still young: "This is the first research showing that oxytocin increases spirituality and it awaits replication," she says.
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Afterward, independent researchers — that is, neither from the original study team nor the replication one — evaluated how closely the study designs matched.
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He said that the original replication paper and the critique use statistical approaches that are "predictably imperfect" for this kind of analysis.
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Computers aren't emotional, but for years, they've been able to guess at the things that will move us, using data and replication.
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While this might sound frightening, mistakes during replication usually produce changes that are neutral or even harmful to the newly generated virus.
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Glimcher sees the current struggles in social science (the problems with replication, with study design, with weak results) and senses an opportunity.
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A simulated replication strategy from 1976 through 2006 based on the S.E.C. filings outperformed the market by over 10 percent a year.
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And for broadcast journalists, she added, the misuse or replication of their voices without permission has the potential to affect their credibility.
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The process requires an enzyme called DNA polymerase, as well as some sort of primer that provides the starting point for replication.
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These and other questions are the domain of the Whitney's replication committee, a little-known but increasingly crucial body within the museum.
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But if it's true that textbooks are still neglecting to cover replication issues, then I'd argue they are actually underselling the science.
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It's also a story about psychology's "replication crisis," in which classic findings are being reevaluated (and often failing) under more rigorous methodology.
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Between p-hacking and replication problems, academic science has started examining how the apparent rigor isn't actually as real as we thought.
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The resulting "replication crisis" had led many scientists to wonder: How many findings in psychological science would hold up in rigorous retesting?
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This is crucial for developing inhibitors of their replication and propagation throughout the brain, which is essential for halting prion-based brain disease.
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But it falls in line with a larger pattern of replication efforts, and demonstrates that there really is a reproducibility problem in science.
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The middle bits were easy: Here's what was found, these are the tests that were done to check it, the replication, the uncertainty.
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Dreaming without limit, he made models for communal living in hive-shaped high-rises, intended for simple replication in cities around the world.
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Kidd, a postdoctoral fellow at the Harvard Graduate School of Education, told BuzzFeed News that the failed replication has taught him a lot.
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If I cannot spare pain to World of Orc-craft's players, then I can at least prevent the replication of my own anxieties.
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Other influential research in psychology has also been toppled by more refined scientific methods lately — that's what the "replication crisis" is all about.
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Additionally, Parihug can link up to your Fitbit, and you can send your loved one a replication of your heartbeat using haptic feedback.
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But while they might yield findings that are worthy of consideration (and replication in more diverse samples), they don't produce universally generalizable results.
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It will actually be a real-time replication of a concert happening in Hamar, Norway at the city's annual tech festival The Gathering.
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The woman chose to get an abortion, and doctors performed an autopsy, where they found viral replication of Zika in the fetus's brain.
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This system targets cellular reservoirs where the HIV virus hides and is capable of suppressing the replication of the virus for extended periods.
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However, scientific findings can only be debunked by scientific data and replication, not by well-meaning lawyers and communication officers lacking scientific training.
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The replication of a low-budget, earnestly progressive public TV broadcast is impeccable, abetted by Helen Mirren's hilariously solemn introductions of the films.
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The company is adding more than a thousand new features on Amazon Web Services including upgrades to storage and the replication of databases.
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This study needs replication; furthermore, the same principle might also apply to anxious mothers and their children, though it has never been tested.
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Mukungulu, however, has seemed more promising: Low concentrations of the remedy caused a 45 percent inhibition of HIV replication in the cells examined.
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But scientific replication is not attained by simply repeating the exact details of an experiment — that is for a grade school science class.
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Replication is best achieved when the findings of the initial study are supported by other studies approaching the same question in different ways.
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Doxorubicin hydrochloride kills cancer cells by preventing DNA replication and protein synthesis, which make it more difficult for the cancer cells to survive.
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Long-held psychological theories are failing replication tests, forcing researchers to question the strength of their methods and the institutions that underlie them.
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Modern constructions of beauty and biological race were heavily influenced by the study, replication, and measurement of classical sculpture in eighteenth century Europe.
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Fevers feel like an unpleasant side effect of infection, but they actually represent the body's strategic response: Higher internal temperature slows viral replication.
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"Often at the time that virus diseases present themselves, it's fairly far into the replication of that virus in that person," Griffin said.
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The banker argued this replication could only lead to debasement of cryptocurrencies to the point where they held no economic value at all.
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Country music and images became fertile ground for asserting the hip-hop aesthetic that wasn&apost just a replication of the urban landscape.
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Once her reshoot was over, Schmidt decided that the direction for her next project would be shifted from filmic recreation to wardrobe replication.
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There's a behavioral principle called mirroring, the subconscious replication of another person's nonverbal cues, which is a way humans connect and grow closer.
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The National Comorbidity Survey Replication found that half of Americans will meet the DSM-IV criteria for a mental disorder in their lifetime.
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If it's true that textbooks and teachers are still neglecting to cover replication issues, then I'd argue they are actually underselling the science.
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Bigtable now features regional replication (or at least it will, once this has rolled out to all users within the next week or so).
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Self-replication is, in fact, an especially good mechanism for stabilizing complex systems, and so it's no surprise that this is what biology uses.
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"The neuropathology, replication potency, and biophysical profiling suggest that a novel, particularly neurotoxic human prion strain was created," declare the authors in the study.
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Their analysis was actually a replication of one conducted by the nonprofit advocacy group Educational Fund to Stop Gun Violence (EFSGV) earlier in December.
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He told the outlet that before all the hubbub over his studies, he'd never heard of the term "p-hacking" or the replication crisis.
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By the time things work up to a fevered inadvertent replication of the Stanford Prison Experiment, it doesn't seem like that great a leap.
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The end result is a screen that aces color-replication tests, and should look face-meltingly good, if you're ever able to afford it.
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The study does have another thing going for it, though: it's a replication study of another one performed by the same team last year.
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You better believe there was a "red room," a perfect replication of the place Agent Cooper knows all too well after all these years.
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We're also going to need to start looking at replication studies with the same critical gaze we reserve for single studies of any kind.
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In both cases, the cells first degrade the features that characterize their differentiation, then reallocate their energy to support replication rather than secreting behavior.
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The episode opens with him recording and attempting to emulate an aborigine weather dance, but he is apprehended by police for this illegal replication.
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This held true even after we statistically adjusted for methodological factors like sample size of the study and the similarity of the replication attempt.
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These spots allow fans to shift attention while remaining in one place, a (much more fun) sort of replication of the home-viewing experience.
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Lab tests of cells engineered to lack the gene showed they resist the flu virus - blocking its entry and halting its replication and spread.
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Gelman's writing on Cuddy's study was coolly dismissive; it bothered him that Cuddy remained fairly silent on the replication and the Data Colada post.
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It creates greater conflicts of interest and bias that may lead to unintentional, or even intentional, research misconduct and contributes to the replication problem.
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"It won't be a replication of what you saw in the Twins Study," said Jennifer Fogarty, the chief scientist at NASA's Human Research Program.
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This suspicion (that nobody is immune to this level of psychological warfare) was confirmed thanks to an independent replication of the experiment in 2017.
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Occasionally, though (less than once in every 17m vaccinations), the replication of such an attenuated virus throws up a mutation which creates a new strain.
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If replication is present, then natural selection becomes the route by which systems acquire the ability to absorb work—Schrödinger's negative entropy—from the environment.
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A subsequent study of 396 different viruses revealed that the evolutionary rate slows at the same rate across almost all genome types and replication strategies.
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The field of psychology, overall, has been reckoning with a "replication crisis" where many classic findings in the science don't hold up under rigorous scrutiny.
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Their offspring did not carry the same mutation in DNA replication, but for the next five generations the gene in question was still incorrectly activated.
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There is nothing in this process that involves the gradual accommodation to the surroundings through the Darwinian mechanisms of replication, mutation and inheritance of traits.
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Throughout California, creative efforts are being made to tackle the obstacles that have slowed implementation of the Sagehen plan and now hamper its replication elsewhere.
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Hepatitis B has been difficult to cure because antiviral medicines that block replication of the virus have proved insufficient at clearing it from the blood.
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The takeaway here is that replication can go off the rails very easily if researchers don't take the utmost care — and even when they do.
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At Vox, we've been diving deep into problems with the scientific process, from the crises in peer review and replication to publishing and sharing research.
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That may be because the portfolio managers are holding out hope that, at some point, they can go back to employing a full replication strategy.
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