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"recapitulate" Definitions
  1. to repeat or give a summary of what has already been said, decided, etc.

130 Sentences With "recapitulate"

How to use recapitulate in a sentence? Find typical usage patterns (collocations)/phrases/context for "recapitulate" and check conjugation/comparative form for "recapitulate". Mastering all the usages of "recapitulate" from sentence examples published by news publications.

You can understand the need to recapitulate, but not in such a flat-footed way.
And yet we are about to recapitulate this accomplishment with the advent of synthetic realities.
When asked if he'd ever cast a differently abled model, for example, Siriano doesn't recapitulate.
The team's mission is to recapitulate this fortuitous coincidence in other crops, by genetic tweaking.
The Court's decision does more than recapitulate some of the worst opinions of our constitutional history.
Her later books rarely rise to the level of "Death and Life," except when they recapitulate it.
There's a risk here that all we're going to do is recapitulate the cable fixed monopoly for access.
To recapitulate, there are strong domestic reasons for the Fed to initiate a program of increasing interest rates.
The trauma of the congressional baseball shooting will unfold and recapitulate itself in our minds for some time.
The best they can hope for in adulthood is not to recapitulate the crimes that were done to them.
In contrast to those investors trying to recapitulate their Chinese success, Amazon is seeking to make up for its failure.
As their pentatonic melodies and Western harmonies recapitulate the cultural conflict, their lyrics achieve the pith and mystery of haiku.
Here, the author is far more interested in the way adults recapitulate teenage behaviors, fretting and sniping and stirring the pot.
There's the even second tenor, which he uses to convey information, or to drily recapitulate somebody else's point before chopping it down.
Andy Beshear opposes Bevin's changes to Medicaid and could recapitulate his father's success in driving the Kentucky uninsurance rate down to record lows.
It's been ten years since Bitcoin launched, and cryptocurrencies have almost exclusively been used to recapitulate existing monetary systems in slightly new forms.
Andy Beshear opposes Bevin's changes to Medicaid and could recapitulate his father's success in driving the Kentucky uninsurance rate down to record lows.
The sooner cities and countries build good data analysis into their approach to curbing crime, the fewer of Latin America's problems they will recapitulate.
Piazza's backstory has been told so often, roughly once for every plate appearance he had, that even now it's a strain to recapitulate it.
"The fact that just a small area of abnormal electrical activity can recapitulate such a fascinating and beautiful picture shows the brain working," she said.
They adjusted their models until they came up with a set of conditions that seemed to recapitulate the fluctuations frozen into that two-mile-long ice tube.
How can we recapitulate all of the traumas and lost dreams — especially the assassinations and descent into violence and despair — without wandering into a muddle of confusion?
It's a clever wrinkle that the two adult women recapitulate the mean-girl theme; onetime schoolmates at Aburi, they are not beyond a bit of bitchery years later.
We can decode the electrical activity that goes into those muscles even before the movement has started and even before it ends and recapitulate that in a virtual way.
It's a live force in American life that works in tandem with structural racism to recapitulate past injustice and reproduce racial disadvantage, a one-two punch that ensures its future.
Thinking that she could add credibility and detail to his work on the sporelike cells, he asked her to recapitulate the study, employing the latest techniques in stem-cell research.
Years later, a group of gaming students from Porto Alegre decided to recapitulate the events that occurred on Prison Island, with an unquestionably terrifying video game also called Prison Island.
In the early 20th century the pooh-bahs of the great powers thought they had solved the problem of war; their age was too enlightened to recapitulate the bloodletting of the past.
There's no need to recapitulate every one of these arguments, but suffice it to say that the artist projected his sexual desires onto his Black subjects in a manner tantamount to fetishized racism.
" Weaver then went on to recapitulate the history of the conflict between the Rajneeshees and other residents of Wasco County, emphasizing that, "the Rajneesh Medical Corporation has a well-equipped laboratory at Rajneeshpuram.
He will recapitulate the old man's fondness for young flesh in his coupling with the Blackmail Girl, enjoy the disapproval of cast and crew when he takes her with him on a set.
When the supporters of the alt-right chant that "Jews will not replace us," they recapitulate the Nazi idea of a world Jewry that stifles the master race and must therefore be removed from the planet.
" David Frum, once a notable Iraq war supporter, writes that war with Iran would recapitulate our Iraq blunders on "a much bigger scale, without allies, without justification, and without any plan at all for what comes next.
Trenchantly, it pits the competing agendas of the different student factions against one another and also denounces the way the men in the movement recapitulate white dominance over blacks in their dealing with women and self-defined queers.
So let's recapitulate: a fake Twitter bot, created by a Russia-funded troll farm in St. Petersburg, claims to be real — maybe I'm American, Canadian, Ecuadorian, she says — or actually to be AI, and we all live in Matrix.
But the play doesn't simply recapitulate the allegations of harassment and assault for the sake of keeping the details in public consciousness—instead, it gives each woman the opportunity to tell her story in the way she sees fit.
The other spiel is intended to recapitulate the themes of Clinton's speech on Trump and the alt-right in which she denounces Trump individually for elevating a handful of extreme and hateful voices that early Republican leaders would have marginalized.
To recapitulate my points, I'm not upset at the article; I found the article to have a very great voice as if a friend was telling me this wacky tale about how Disney is trying to market to a weird group on the internet.
But rather than craft policies to do any of that, Trumpism is proving to be an enormous bait-and-switch whose strategy for boosting the economy is to recapitulate George W. Bush's agenda of cutting taxes for the rich and hoping for the best.
However, Miller forces the viewer's hand as she confronts us head-on with powerful testimonies from her subjects, who recapitulate their tales of woe to a contemporary art audience that is left trying to situate itself in a liminal space that does not affirm or deny meaning.
In the same week, scientists announced they can cure HIV in mice, courtesy of CRISPR — and the wealthiest nation in the world, again apparently trying to recapitulate the 19th century, stripped healthcare from 24 million of its poorest citizens in favor of tax cuts for its wealthiest residents.
It was hard not to see that conviction reflected in the findings of Reich's papers, which seemed to blithely recapitulate discredited theories of Pacific expansion, making categorical claims not only about four individual skulls but about the shape of human history — claims that were essentially indistinguishable from the racialized notions of the swashbuckling imperial era.
Or it might skip gene sequencing altogether: In my own laboratory, a postdoctoral researcher is trying to grow cancer cells from individual patients in the form of tiny "organoids" — three-dimensional cellular structures that recapitulate living tumors — and testing thousands of drugs to find ones that might work in these organoids before deploying them on patients.
He would have liked to text her, or even call her, for some reassurance—and to recapitulate every sentiment of the past hour and then, as the conversation meandered, to exchange the bolder impressions that each must have of the other, which could come spilling out now that they had broken through to a new level of intimacy.
In effect, the monument, a maquette of which is on display in Albany, manages to recapitulate the marginalization black women experienced during the suffrage movement to begin with, when, to cite but one example, they were forced by white organizers to congregate in the back during a famous women's march, in Washington, in 1913, coinciding with Woodrow Wilson's inauguration.
But you've marked the moment, and you have opened the door to say, if at some point you notice you're having difficulty saying what you want to say, just know that it's okay — including if it's about me, my body, how I'm constituted, and the way it's impacting you — and a crucial recognition is that regardless of positive intentions, all of the social, political, and economic dynamics outside of the room may recapitulate in the room.
The verses for Gampar and Tuiscon recapitulate what Aventinus recorded in Annals of Bavaria.
I've written an essay expanding upon my reasons for disesteeming his work, so I won't recapitulate those reasons here.
Native-centric molecular dynamics simulations recapitulate the experimental results and point the way to testable computational models for complex folding mechanisms.
Three weeks after casting had begun, Trevellick decided to recapitulate the first auditions, realising that Armitage was "perfect".Staff writer (June 2007). "A Northern Tale". The DVD Collection.
John Martin. Several features make Manfred unique among Tchaikovsky's works. It is the only programmatic work he wrote in more than one movement. The first two movements do not recapitulate their middle sections.
Both approaches are considered complementary and may be used to recapitulate different aspects of disease. GEMMs are also of great interest for drug development, as they facilitate target validation and the study of response, resistance, toxicity and pharmacodynamics.
Babymetal - playful commanding symbolism within Pop Metal culture.Ravers 2010 - wearing children's "kandy" beads, along with teething symbolism.The hypothesis suggests that teenagers recapitulate infancy and childhood through pop culture. This self-referencing process supposedly leads to the manifestation of social symbols.
The ΔlaeA mutant showed increased susceptibility to macrophage phagocytosis and decreased ability to kill neutrophils ex vivo. LaeA regulated toxins, besides gliotoxin, likely have a role in virulence since loss of gliotoxin production alone did not recapitulate the hypo-virulent ∆laeA pathotype.
Dormann, S. and Deutsch, A. (2002). Modelling of self-organized avascular tumour growth with a hybrid cellular automaton. In Silico Biology 2: 393 – 406. As well, vessel growth and flow dynamics in tumours are thought to recapitulate the vessel growth in developing embryos.
5q- myelodysplastic syndrome (MDS) is associated with acquired haplo-insufficiency of RPS14, a component of the eukaryotic small ribosomal subunit (40S). RPS14 is critical for 40S assembly, and depletion of RPS14 in human CD34(+) cells is sufficient to recapitulate the 5q- defect of erythropoiesis with sparing of megakaryocytes.
J. Brandon Dixon is a Professor of Mechanical and Biomedical Engineering at the Georgia Institute of Technology. He heads the Laboratory of Lymphatic Biology and Bioengineering (LLBB). Among his most recent publications, Dr. Dixon developed a tissue engineered in vitro model to recapitulate lipid uptake by intestinal lymphatics.Dixon, J. Brandon.
Art is an open field no longer divided by the objective versus non-objective dichotomy. Artists can achieve critical success whether their images are representational or abstract. What has currency is content, exploring the boundaries of the medium, and a refusal to recapitulate the works of the past as an end goal.
The climax then ensues as both hands alternate on the same notes that climb 5 octaves up the keyboard and down again, then fires up again and down again. Then the right hand arpeggios recapitulate and the right hand flies even higher and steeper. After a few more loud chords, the piece finally relents.
The partial recapitulations sometimes briefly recapitulate the second theme in the tonic key at the end of the first theme as a "false start", before the transition arrives, which then the transition leads to the actual second theme in the tonic before the closing section. An example occurs in the first movement of Haydn's Piano Sonata Hob. XVI-23.
Henry Fillmore and Karl King often used the four-part style in their marches. Sousa rarely used this style. Sousa's marches of the early 1890s (including "High School Cadets" and "Manhattan Beach"), used an introduction unique to his career. Many earlier American and European marches, using either the four-part or the regimental form, recapitulate back to the beginning of the march.
That does > not happen in Oceania. The tupapau is just the thing... According to > Tahitian beliefs, the title Manao tupapau has a double meaning... either she > thinks of the ghost or the ghost thinks of her. To recapitulate: Musical > part - undulating horizontal lines - harmonies in orange and blue linked by > yellows and violets, from which they derive. The light and the greenish > sparks.
These are NKp30, Nkp44 and Nkp46. To recapitulate, these ligands activate the NK, as we explained. However, before the activation, Killer Inhibition Receptors (KIRs) recognize certain molecules in the MHC class I of the hosted cell and get engaged with them. These molecules are typical of healthy cells but some of these molecules are repressed in infected or transformed cells.
Hughes (1970) p. 186. The variations are for the most part strophic and straightforward with the exception of a minor-key interlude in the center of the movement between the first and second variations. The final variation contains the fullest orchestration with pizzicato accompaniment and serves to recapitulate the movement.A. Peter Brown, The Symphonic Repertoire (Volume 2) (Bloomington and London: Indiana University Press, 2001) (), pp. 207–208.
Rhabdomyoma is a benign mesenchymal tumor of skeletal muscle, separated into two major categories based on site: Cardiac and extracardiac. They are further separated by histology: fetal (myxoid and cellular), juvenile (intermediate), and adult types. Genital types are recognized, but are often part of either the fetal or juvenile types. The fetal type is thought to recapitulate immature skeletal muscle at about week six to ten of gestational development.
LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene. This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.
The Berkeley Lights Beacon platform has resolved the issue of collection and detection by performing microfluidic culture on an array of photoconductors which can be optoelectrically activated to manipulate cells across the chip. This platform has been adopted by Amgen and Novartis for cell line development in the biopharmaceutical industry. Micropatterned co-cultures have also contributed to bio-MEMS for tissue engineering to recapitulate in vivo conditions and 3D natural structure.
Gerald James Larson (2008), Reviewed Work: Kiss of the Yoginī: "Tantric Sex" in Its South Asian Contexts by David Gordon White, Journal of the American Oriental Society, Vol. 128, No. 1 (Jan. - Mar., 2008), pages 154–157 Yet, emotions, eroticism and sex are universally regarded in Tantric literature as natural, desirable, a means of transformation of the deity within, to "reflect and recapitulate the bliss of Shiva and Shakti".
Belief in prenatal fetal awareness, mental communication between mother and unborn child, and emotional attachment of child to mother as a prenatal phenomenon, are concepts that connect easily to the unfounded assumption that all adopted children suffer emotional disorders. These beliefs are also congruent with CAM psychotherapies such as attachment therapy (not based on attachment theory), which purport to bring about age regression and to recapitulate early development to produce a better outcome.
Municipalities and regions of Georgia According to the Georgian law, a municipality is a settlement or a group of settlement with defined borders and self-government. There are two types of municipalities—self-governing cities, five in total, and self-governing communities, 64 in total as of January 2019. The current municipalities were established between 2006 and 2017. Most of the municipalities recapitulate the boundaries and names of earlier subdivisions, known as raioni (district).
Gastric organoids recapitulate at least partly the physiology of the stomach. Gastric organoids have been generated directly from pluripotent stem cells through the temporal manipulation of the FGF, WNT, BMP, retinoic acid and EGF signalling pathways in three-dimensional culture conditions. Gastric organoids have also been generated using LGR5 expressing stomach adult stem cells. Gastric organoids have been used as model for the study of cancer along with human disease and development.
A more lyrical second subject follows, before the main motives return to recapitulate in the shortest opening movement of all Bax's symphonies. Likewise, the idyllic middle movement is Bax's shortest second movement. The violins introduce the main melody near the beginning and it is eventually taken up by the other sections of the orchestra, with an almost jazzy trumpet solo in the middle. It ends peacefully as to set up the last movement.
Despite appearing publicly in the film, for several decades Kayser was unwilling to conduct in-depth interviews about his wartime actions. He cited recurring nightmares as the reason for his unwillingness to recapitulate the war period. Ultimately, the writer Kjell Harald Lunde got Kayser's consent, and in 1997 Lunde published the book Sabotøren ('The Saboteur'). Kayser had participated in a Norwegian Broadcasting Corporation production on Bjørn West in the spring of 1994.
Diptericins are found throughout Diptera, but are most extensively characterized in Drosophila fruit flies. The mature structures of diptericins are unknown, though previous efforts to synthesize Diptericin have suggested Diptericin in Protophormia terraenovae is one linear peptide. Yet Drosophila melanogaster's Diptericin B peptide is likely cleaved into two separate peptides. Synthesis of Diptericin in vitro found activity of the full-length peptide, but independently synthesizing the two peptides and mixing them does not recapitulate Diptericin activity.
The ability to recapitulate spermatogenesis In vitro provides a unique opportunity to study this biological process through oftentimes cheaper and faster method of research than in vivo work. Observation is often easier in vitro, as the targeted cells are mostly isolated and immobile. Another significant advantage of in vitro research is the ease with which environmental factors can be changed and monitored. There are also techniques which are not practical or feasible in vivo which can now be explored.
In 2015, several research groups presented experimental evidence that chromothripsis is indeed caused by a single catastrophic event. Using a combination of live cell imaging and single-cell genome sequencing of manually isolated cells, it was shown that micronucleus formation can generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis. Additionally, research studies inducing telomere crises followed by sequencing the resultant clones demonstrated complex DNA rearrangements that directly recapitulated the one- off chromosomal catastrophe model of chromothripsis.
Afterward the strings commence a momentary moment of fluidity before they are interrupted by a wailing trombone which gives the impression of a Russian circus. A march rhythm accompanies this action, trumpets buzzing almost disconcertedly. The flutes return with the second theme, before the trombones recapitulate the opening material, creating an almost competitive environment in which various sections of the orchestra struggle for supremacy. In a brief return to lyricism, the strings play a shiny passage with some playful woodwinds beneath.
Lingual organoids are organoids that recapitulate, at least partly, aspects of the tongue physiology. Epithelial lingual organoids have been generated using BMI1 expressing epithelial stem cells in three-dimensional culture conditions through the manipulation of EGF, WNT, and TGF-β. This organoid culture, however, lacks taste receptors, as these cells do not arise from Bmi1 expressing epithelial stem cells. Lingual taste bud organoids containing taste cells, however, have been created using the LGR5+ or CD44+ stem/progenitor cells of circumvallate (CV) papilla tissue.
In 2019, Engle returned to the Salk as an assistant professor. Her lab is focused on improving detection and treatment of pancreatic cancer which has the highest mortality rate of all major cancers. Since starting in 2019, Engle’s lab has begun creating transgenic mouse models of pancreatic cancer that have tumors that express the uniquely human CA19-9 tumor antigen. This will allow the lab to better recapitulate the human tumor environment and move towards better diagnostics and treatments for pancreatic cancer.
Oligodendrogliomas recapitulate the appearance of the normal resident oligodendroglia of the brain. (Their name derives from the Greek roots 'oligo' meaning " few" and 'dendro' meaning "trees".) They are generally composed of cells with small to slightly enlarged round nuclei with dark, compact nuclei and a small amount of eosinophilic cytoplasm. They are often referred to as "fried egg" cells due to their histologic appearance. They appear as a monotonous population of mildly enlarged round cells infiltrating normal brain parenchyma and producing vague nodules.
The variations overlap twice (theme with variation 1, variation 3 with variation 4) in that the first half for the two variations in sequence followed by the second half for each. Both times this is done to contrast a staccato variation with a legato one. For the most part, the movement is for muted strings only, with notable wind outbursts in the second variation as well as the use of full tutti in the seventh variation which serves to recapitulate the movement.
In the remake, she is abducted and held hostage by Brian Irons before being rescued by Claire. Her father has been transformed into a monstrous creature by the G-virus and infects her, but Claire gives Sherry an anti-virus, which prevents her from mutating. Sherry assists Leon and Claire in boarding a secret underground train, and successfully escapes Raccoon City before it is destroyed. Sherry also appears in Resident Evil: The Darkside Chronicles in chapters that recapitulate the events of Resident Evil 2.
Mishnah Nega'im 11:5 If, the eruption returns to the patch, there is no confinement period instituted and the entire garment is completely burnt.;Leviticus 13:57, commentary of Rashi if a negah reappears on the garment but not on the patch, the garment must be burned but the patch can be saved.Mishnah Nega'im 11:6 To recapitulate, if the negah remained as it was after the first week of confinement, it is washed and reconfined. If it remained as it was after the second week of confinement, it is burned.
With this, one should be able to recapitulate the artistical-cultural ambiente which rotated around the character and charisma of Remo Rossi towards the beginning of the sixties. The Foundation has already opened a provisory Museum (Museo Remo Rossi) and in the mid term will make also accessible the extremely rich Art's collection of Remo and a Documentation center. All these shall be situated in the family house of Remo Rossi in Via Rusca in Locarno. The Foundation has been started by following the will of Remo's son Giancarlo who died in 2008.
The wide range of thematic material presented in the orchestral and solo expositions poses a challenge for the recapitulation. Mozart manages to recapitulate all of the themes in the home key of C minor. The themes are necessarily compressed, are presented in a different order, and in their restated form, contain few virtuosic moments for the soloist. The last theme to be recapitulated is the secondary theme of the orchestral exposition, which has not been heard for some 400 measures and is now adorned by a passage of triplets from the piano.
Organoids offer researchers an exceptional model to study developmental biology. Since the identification of pluripotent stem cells, there have been great advancements in directing pluripotent stem cells fate in vitro using 2D cultures. These advancements in PSC fate direction, coupled with the advancements in 3D culturing techniques allowed for the creation of organoids that recapitulate the properties of various specific subregions of a multitude of organs. The use of these organoids has thus greatly contributed to expanding our understanding of the processes of organogenesis, and the field of developmental biology.
Thus the ideas of the team and the quality of work done by Ernest Henry achieved victory over everything before them. With these engines, Ernest Henry may claim the undisputed paternity landmark in the history of the automobile. They are not the first "4 valves per cylinder" or the first "dual overhead cam head," but they are the first in the world to combine the two techniques. All the most powerful racing engines, to the current Formula 1 recapitulate this formula, which is now becoming universal in production automobiles.
Her work focuses on the molecular aspects of kidney development, with applications to stem cell biology and regenerative medicine. Little and her team have developed an approach to recapitulate nephrogenesis, the formation of nephrons, in a dish. By knowing where the different kidney cells come from and how they develop she has developed a system to regenerate them from pluripotent stem cells. Using embryonic stem cells, or induced pluripotent stem cells from a patient, her group has described a cocktail of growth factors that can drive development into kidney cells.
The Prime of Miss Jean Brodie was adapted by Scottish Television into a seven episode television serial for ITV in 1978 that featured Geraldine McEwan in the lead role. Rather than recapitulate the plot of the novel, the series imagined episodes in the lives of the characters, such as conflict between Jean Brodie and the father of an Italian refugee student, who fled Mussolini's Italy because the father was persecuted as a journalist who objected to fascism. It consisted of seven episodes of 60 minutes. It was released on DVD in Region 1 and 2.
Persson said in response to these claims: "I can't exactly recapitulate the event but I can say as much that I'm surprised that Pär Nuder remembers anything". In September 2003 Persson was diagnosed with hip osteoarthritis and surgery was recommended. He chose to go through Sweden's public health-care system instead of seeking private treatment; he was put on a waiting list, and finally received a hip replacement operation in June 2004. During that 9-month period he walked with a limp and reportedly was on strong painkillers; he had to cancel several official trips due to the pain he was in.
Most knowledge regarding PTSD comes from studies in high-income countries. To recapitulate some of the neurological and neurobehavioral symptoms experienced by the veteran population of recent conflicts in Iraq and Afghanistan, researchers at the Roskamp Institute and the James A Haley Veteran's Hospital (Tampa) have developed an animal model to study the consequences of mild traumatic brain injury (mTBI) and PTSD. In the laboratory, the researchers exposed mice to a repeated session of unpredictable stressor (i.e. predator odor while restrained), and physical trauma in the form of inescapable foot-shock, and this was also combined with a mTBI.
Okumu's research interests include the effectiveness of Mosquito nets, the evolution of Insecticide resistance in mosquitoes and methods of trapping and killing wild mosquitoes. Okumu places a strong emphasis on the use of field studies to determine the effectiveness of mosquito-control strategies. Many devices are tested thoroughly in lab settings however these may not recapitulate the effects in the real world. Okumu has been involved in field studies using mosquito baits near his institute and in local villages to test their effectiveness in situ. The IHI possesses the largest mosquito rearing facility in the world, known as the ‘mosquito farm’.
HMS Beagle, Charles Darwin collected numerous specimens, many new to science, which supported his later theory of evolution by natural selection. The simplest and most powerful evidence is provided by phylogenetic reconstruction. Such reconstructions, especially when done using slowly evolving protein sequences, are often quite robust and can be used to reconstruct a great deal of the evolutionary history of modern organisms (and even in some instances of the evolutionary history of extinct organisms, such as the recovered gene sequences of mammoths or Neanderthals). These reconstructed phylogenies recapitulate the relationships established through morphological and biochemical studies.
While the work is mainly in D, it begins and ends on a C. This, writes noted Australian Liszt scholar and pianist Leslie Howard,Howard recorded all of Liszt's solo piano pieces (over 95 CDs) and has written extensively on Liszt's work. was an encouragement while working on his performing version to refer to the main material in the slow Andantino and to recapitulate a portion of the fast Allegro before Liszt's coda.Howard, Waltzes, 4. Some critics do not consider this waltz as original as its predecessors and surmise that, had Liszt lived to complete it, he might have made considerable improvements.
Microscopically, the tumor cells recapitulate embryonic sensory retina or nonpigmented ciliary epithelium. The chalky grayish-white particles within the tumor mass correspond to foci of cartilage on histology; the semi-translucent membrane covering the lens in some tumors corresponds to spreading neoplastic cells. Tumor cells form a characteristic diktyomatous pattern, with folded cords and sheets resembling a fisherman's net. In early development of the retina, the medullary epithelial cells acquire polarity, such that a basement membrane associated with the vitreous forms the internal limiting membrane on one side, while terminal bars form the outer limiting membrane on the other side.
Because endogenous wild-type proteins cannot be visualised in vivo, fusion proteins must be created and their plasmids transfected into the cells studied. These fusion proteins may not recapitulate the functions, localisation, and interactions common to their wild-type counterparts, providing an inaccurate picture of the proteins in question. This problem can be alleviated by using structural information and the location of interaction sites to rationally identify fusion sites on the proteins of interest, using appropriate controls, and comparing the expression levels and functions of the fusion and wild-type proteins through Western Blots and functional assays.
As similar research is yielding results in various other malignant diseases, it is hoped that identifying the aberrant genes and the resultant proteins could lead to the identification of pharmacological interventions for HCC. The development of three-dimensional culture methods provides a new approach for preclinical studies of cancer therapy using patient-derived organoids. These miniaturized organoid 'avatars' of a patient's tumor recapitulate several features of the original tumor, rendering them an attractive model for drug-sensitivity testing and precision medicine for HCC and other types of primary liver cancer. Furthermore, HCC occurs in patients with liver disease.
In their analysis of substituted benzene dimers in a sandwich conformation, they were able to recapitulate their findings using an exceedingly simple model where the substituted benzene, Ph–X, was replaced by H–X. Remarkably, this crude model resulted in the same trend in relative interaction energies, and correlated strongly with the values calculated for Ph–X. This finding suggests that substituent effects in the benzene dimer are due to direct interaction of the substituent with the aromatic ring, and that the pi system of the substituted benzene is not involved. This latter point is expanded upon below.
Beating cardiac muscle cells, iPSC-derived cardiomyocytes, can be mass-produced using chemically-defined differentiation protocols. These protocols typically modulate the same developmental signaling pathways required for heart development . These iPSC-cardiomyocytes can recapitulate genetic arrhythmias and cardiac drug responses, since they exhibit the same genetic background as the patient from which they were derived. In June 2014, Takara Bio received technology transfer from iHeart Japan, a venture company from Kyoto University's iPS Cell Research Institute, to make it possible to exclusively use technologies and patents that induce differentiation of iPS cells into cardiomyocytes in Asia.
Therefore, the delivery of morphogens to EBs results in increased heterogeneity and decreased efficiency of differentiated cell populations compared to monolayer cultures. One method of addressing transport limitations within EBs has been through polymeric delivery of morphogens from within the EB structure. Additionally, EBs can be cultured as individual microtissues and subsequently assembled into larger structures for tissue engineering applications. Although the complexity resulting from the three- dimensional adhesions and signaling may recapitulate more native tissue structures, it also creates challenges for understanding the relative contributions of mechanical, chemical, and physical signals to the resulting cell phenotypes and morphogenesis.
Since Descartes, philosophers have been occupied with the concept of consciousness and its subjective nature has posed a special problem for science. Its nature arises from the neuronal structures in the brain and some understanding of these, together with the experimental tools needed to explore them, is given in the following chapters. They then recapitulate Edelman's still controversial theory of somatic selectionism during early development which controls the topology of a particular brain and enables restructuring in response to experience. They argue that memory is not a symbolic representation but a reflection of how the brain has changed its dynamics in order to achieve motor activity.
This discovery was hailed as the people's choice for the scientific breakthrough of 2016 by Science magazine. The knowledge she gained through her work on how the embryo develops during the blastocyst to gastrula transition, allowed her to mimic these developmental processes with different types of stem cells in vitro. This led her to the pioneering success of constructing embryo-like structures from pluripotent embryonic and multipotent extra-embryonic (trophoblast) stem cells in a 3D scaffold of extra-cellular matrix proteins in vitro. These "synthetic embryos" recapitulate the natural architecture of the embryo and their patterns of gene expression leading to the specification of the germ layers and germ cells.
In 1628, when Richard Neile went before the House of Commons of England accused of anti-puritan practices, Beard was summoned as a witness against him. Cromwell's speech in the debate on the subject covers his likely testimony (the parliament was dissolved before Beard could testify). Beard had been appointed in 1617 to preach a sermon on the Sunday after Easter in London, in which, according to custom, he was to recapitulate three sermons previously preached before the lord mayor from an open pulpit in Spital Square. William Alabaster was the preacher whom Beard had to follow, but he announced his intention of exposing Alabaster's support of certain tenets of popery.
Noting that one of the major themes of the Book of Acts is that "Christ's servants follow in His footsteps," Jordan argues that the events of the chapter "recapitulate the resurrection of Jesus."James B. Jordan, The Resurrection of Peter and the Coming of the Kingdom, Biblical Horizons 34. Amy-Jill Levine and Marianne Blickenstaff, like Jordan, relate the disbelief of Rhoda's message to Luke 24:1–12, where most of the disciples refuse to believe the news of the resurrection brought by a group of women.Amy-Jill Levine and Marianne Blickenstaff , A Feminist Companion to the Acts of the Apostles, Continuum, 2004, , p. 103.
In the Higurashi games, there are several story arcs, the original eight of which are referred to as either question arcs or answer arcs. The answer arcs generally recapitulate the events of the corresponding question arc, but from a different perspective, using the change of protagonist to solve various mysteries and come to a different conclusion. Each of the eight original games for the PC represented separate arcs of the overall storyline. Apart from the main question and answer relationship, the story of the arcs are not directly connected, although a multitude of parallels exist which allow the observant reader to gain extra insight into the mystery.
She argues that "the most important contribution of postcolonial feminist theology will be to recapitulate the relation of theology and empire through the multiple lenses of gender, race, class, sexuality, religion, and so forth." The aim of her work is to create a theology that more accurately reflects the multiple levels of oppression that women in postcolonial contexts face. Kwok views God as organic, and places the belief in the context of the growing ecological crisis in Asia. She also examines the concept of constructing a Christology using an organic model, referring to the multiple nature references Jesus uses to describe himself and his relationship with believers.
Today, guests generally enter the Palau through the foyer, which was created in the renovations of Tusquets and Díaz from what originally were the headquarters of the Orfeó Català. The large space of the foyer is more soberly decorated than the rest of the Palau, but the wide exposed brick arches with their marvelous glazed green, pink, and yellow ceramic flowers recapitulate the ornamentation of the rest of building. The foyer features a large counter where tapas and beverages can be served to concert-goers or visitors who are touring the building. The bar is situated between massive pillars of brick and is illuminated from behind by expansive stained-glass panes that are suspended above it.
SCOPE was then used to construct a synthetic enzyme lineage, which was biochemically characterized to recapitulate the evolutionary divergence of two modern day enzymes. The rapid evolvability of chemical diversity in terpene synthases were demonstrated through processes akin to both Darwinian gradualism and saltation: some mutational pathways show steady, additive changes, whereas others show drastic jumps between contrasting product specificities with single mutational steps. Further, a metric was devised to describe the chemical distance of mutational steps to derive a chemical-based phylogeny relating sequence variation to chemical output. These examples establish SCOPE as a standardized method for the construction of synthetic gene libraries from close or distantly related parental sequences to identify functional novelty among the encoded proteins.
He had bogies on the 5th, 6th, 7th, and 8th holes, and was all for quitting. But, comes a 9th and a birdie, the 10th and a birdie, the 11th and a birdie, the 12th and another birdie, the 13th and a par, the 14th and an eagle, the 15th and a birdie, and the 16th still another birdie. To recapitulate, his score at Winged Foot was eight under par for eight consecutive holes, the 9th through the 16th. The 14th hole eagle was something in itself; it was a par four, 383-yarder. He smashed his tee shot straight down the middle and then holed a niblick from more than 100 yards out.
In the field of microbiome research, a group of species is said to show a phylosymbiotic signal if the degree of similarity between the species' microbiomes recapitulates to a significant extent their evolutionary history. In other words, a phylosymbiotic signal among a group of species is evident if their microbiome similarity dendrogram could significantly recapitulate their host's phylogenic tree. For the analysis of the phylosymbiotic signal to be reliable, environmental differences that could shape the host microbiome should be either eliminated or accounted for. One plausible mechanistic explanation for such phenomena could be, for example, a result of host immune genes that rapidly evolve in a continuous arms race with members of its microbiome.
Within the endomembrane system, BLOC-1 acts at the early endosome, as witnessed in electron microscopy experiments, where it helps coordinate protein-sorting of LAMPS (lysosome-associate membrane proteins). Multiple studies recapitulate an association with the adaptor complex AP-3, a protein involved in vesicular trafficking of cargo from the early endosome to lysosomal compartments. BLOC-1 demonstrates physical association with AP-3 and BLOC-2 upon immunoprecipitation, although not to both complexes at the same time. Indeed, BLOC-1 functions in an AP-3 dependent route to sort CD63 (LAMP3) and Tyrp1. Furthermore, another study suggests an AP-3 dependent route of BLOC-1 also facilitates trafficking of LAMP1 and Vamp7-T1, a SNARE protein.
The device's design requirements would require the filtration fraction in the glomerulus to vary between 15–20%, or the filtration reabsorption in the proximal convoluted tubule to vary between 65–70%, and finally the urea concentration in urine (collected at one of the two outlets of the device) to vary between 200–400 mM. One recent report illustrates a biomimic nephron on hydrogel microfluidic devices with establishing the function of passive diffusion. The complex physiological function of nephron is achieved on the basis of interactions between vessels and tubules (both are hollow channels). However, conventional laboratory techniques usually focus on 2D structures, such as petri-dish that lacks capability to recapitulate real physiology that occurs in 3D.
In 1995 Boury-Esnault and Jean Vacelet discovered the first species of carnivorous sponges, of the Chondrocladia genus, during an exploration of a shallow cave in the Mediterranean. Caves can recapitulate the environment of the deep sea-bed due to the darkness and lack of nutrient, permitting the study of deep-sea-like regions in shallow areas of water. Carnivorous sponges, lacking the normal filter feeding apparatus, had been previously discovered during deep-sea trawls and presumed to be damaged since they did not have a known feeding mechanism. The discovery of members of the family in shallow water meant that they could be experimentally tested, which is when Boury-Esnault and Vacelet observed feeding on small crustaceans.
Intestinal organoids have thus far been among the gut organoids to be generated directly from pluripotent stem cells. One way human pluripotent stem cells can be driven to form intestinal organoids is through first the application of activin A to drive the cells into a mesoendodermal identity, followed by the pharmacological upregulation of Wnt3a and Fgf4 signaling pathways as they have been demonstrated to promote posterior gut fate. Intestinal organoids have also been generated from intestinal stem cells, extracted from adult tissue and cultured in 3D media. Intestinal organoids recapitulate the crypt-villus structure of the intestine, by recapitulating its function, physiology and organization, and maintaining all the cell types found normally in the structure including intestinal stem cells.
Thus, intestinal organoids are a valuable model to study intestinal nutrient transport, drug absorption and incretin hormone secretion. Intestinal organoids recapitulate the crypt-Villus structure to high degree of fidelity that they have been successfully transplanted to mouse intestines, and are hence highly regarded as a valuable model for research. One of the fields of research that intestinal organoids have been utilized is that of stem cell niche. Intestinal organoids were used to study the nature of the intestinal stem cell niche, and research done with them demonstrated the positive role IL-22 has in maintaining in intestinal stem cells, along with demonstrating the roles of other cell types like neurons and fibroblasts in maintenance of intestinal stem cells.
In spite of a burgeoning literature supporting TPCs as the NAADP-regulated channel, this was challenged in 2012/13 by reports that TPCs are, instead, Na+ channels regulated by the endo-lysosomal lipid, Phosphatidylinositol 3,5-bisphosphate, PI(3,5)P2 and also by metabolic state (via ATP and mTOR). As a result of this, several groups reinvestigated the permeability properties of TPCs and their role in NAADP-induced Ca2+ release. They agreed that TPCs are indeed permeable to Na+ but they could not necessarily recapitulate the Na+ selectivity shown in the 2012/13 studies. These groups therefore concluded that TPCs were cation channels that conducted both Ca2+ and Na+ (analogous to the NMDA receptor of the plasma membrane).
They found myelination to be a characteristics of each neural subtype reflecting random interaction between neurons and oligodendrocytes, myelinating cells of the CNS. Arlotta and her team propose that this diversity and stochasticity of myelination underlies the diverse array of communication patterns that arise in the cortex. Arlotta also develops and applies brain organoids to test various aspects of brain development and neurogenesis in models that better recapitulate the CNS but are more malleable to testing. Arlotta led a team of researchers towards developing organoids that were able to grow for up to 9 months, generate dendritic spines, as well as a broad array of diverse cells types as would be observed in the human brain.
Brian Eno (2012) produced three of the album's songs. Ocean of Sound is a two-disc, cross-licensed "various artists" compilation that contains 32 tracks culled from a variety of musical sources, including dub, exotica, free jazz, and field recordings. According to AllMusic's John Bush, all of the songs compiled for the album recapitulate the theme of the book—"that Les Baxter, Aphex Twin, The Beach Boys, Herbie Hancock, King Tubby and My Bloody Valentine are all related by their effect on sound pioneering." In an interview for Perfect Sound Forever, Toop explained why he included free jazz on an album of ambient music, which is commonly thought of as background music: Toop programmed the recordings for the album so that they would segue into one another.
Florin Giripescu Sutton (1991),Existence and Enlightenment in the Laṅkāvatāra-sūtra: A Study in the Ontology and Epistemology of the Yogācāra School of Mahāyāna Buddhism, p.104 Shcherbatskoy gives the following example from the Mahabharata (Shantiparva, 181.22): "Just as the footprints of birds (flying) in the sky and fish (swimming) in water cannot be seen, Thus (tātha) is going (gati) of those who have realized the Truth." The French author René Guénon, in an essay distinguishing between Pratyēka-Buddhas and Bodhisattvas, writes that the former appear outwardly superior to the latter, simply because they are allowed to remain impassible, whereas the latter must in some sense appear to rediscover “a way” or at least recapitulate it, so that others, too, may “go that way,” hence tathā-gata.
In 2012, Garcia's laboratory determined the crystal structure of a Wnt protein in complex with its cellular receptor, Frizzled.Structural basis of Wnt recognition by Frizzled, Science (2012) The Wnt-Frizzled structure indicated that Wnts utilize a post- translational lipid modification to directly engage the Frizzled extracellular domain, which represents a highly unusual binding mode among soluble ligands. Garcia's study revealed a striking, donut-shaped architecture adopted by the Wnt-Frizzled complex that adorns the cover of the July 6th, 2012 issue of Science. More recently, Garcia's laboratory reported a breakthrough in being able to recapitulate canonical Wnt signaling using water-soluble bispecific ligands that dimerize Frizzled and Lrp6, which has important implications for the development of therapeutics for regenerative medicine.
Exosomes mediate regenerative outcomes in injury and disease that recapitulate observed bioactivity of stem cell populations. Mesenchymal stem cell exosomes were found to activate several signaling pathways important in wound healing (Akt, ERK, and STAT3), bone fracture repair and participates in the regulation of immune-mediated responses and inflammatory diseases. They induce the expression of a number of growth factors (hepatocyte growth factor (HGF), insulin-like growth factor-1 (IGF1), nerve growth factor (NGF), and stromal-derived growth factor-1 (SDF1)). Exosomes secreted by human circulating fibrocytes, a population of mesenchymal progenitors involved in normal wound healing via paracrine signaling, exhibited in-vitro proangiogenic properties, activated diabetic dermal fibroblasts, induced the migration and proliferation of diabetic keratinocytes, and accelerated wound closure in diabetic mice in vivo.
These differences were, in turn, caused by "heredity". His compared the shapes of embryonic structures to those of rubber tubes that could be slit and bent, illustrating these comparisons with accurate drawings. Stephen Jay Gould noted in his 1977 book Ontogeny and Phylogeny that His's attack on Haeckel's recapitulation theory was far more fundamental than that of any empirical critic, as it effectively stated that Haeckel's "biogenetic law" was irrelevant. Embryology theories of Ernst Haeckel and Karl Ernst von Baer compared Darwin proposed that embryos resembled each other since they shared a common ancestor, which presumably had a similar embryo, but that development did not necessarily recapitulate phylogeny: he saw no reason to suppose that an embryo at any stage resembled an adult of any ancestor.
Skinned trabeculae or cardiac myocytes obtained from human patients carrying a MYBPC3 mutation or from heterozygous and homozygous Mybpc3-targeted knock-in mice exhibited higher myofilament Ca2+ sensitivity than controls. Disease-modeling by engineered heart tissue (EHT) technology with cardiac cells from heterozygous or homozygous Mybpc3-targeted knock-in mice reproduced observations made in human and mouse studies displaying abbreviated contractions, greater sensitivity to external Ca2+ and smaller inotropic responses to various drugs (isoprenaline, EMD 57033 and verapamil) compared to wild-type control EHTs. Therefore, EHTs are suitable to model the disease phenotype and recapitulate functional alterations found in mice with hypertrophic cardiomyopathy. Another good system for modeling cardiomyopathies in the cell culture dish is the derivation of cardiac myocytes from iPSC.
Jessica Letkemann of Billboard was acceptive of the "delicious sundown grooves" of the quieter piece and "the Foos' usual soft-louder-loudest 'radio friendly unit shifters'" - referencing a track of Nirvana's In Utero – while considering "Home" the only disappointing track. Robert Christgau rated the album a B, describing it as a "candid attempt to recapitulate Nirvana Mark II's 10-year-old triumph, The Colour and the Shape". Henrik Holmgren of Melodic praised the production of the album and felt that Grohl singing "gets better and better with every record." Dave Simpson of The Guardian called Echoes, Silence, Patience & Grace the band's "most accomplished album", praising the composition and saying that "Gil Norton's stunning production can't disguise the raw humanity beneath the sheen".
Established in 1918, the Melfort green tea factory gives Sri Lanka the pride of being able to treat tea lovers around the globe with the finest blend of green tea that has won the acclamation of generations due health benefits it provides. It is no rocket science that many brands not only prefer but demand our green tea as it is being processed at our processing plant at Sanquhar estate which is the oldest tea plantation in Sri Lanka, dating back to the 19th century. Rothschild Tea Estate The 2000-acre Rothschild estate at Pussellawa was well known for its completeness and efficiency and was held up as a model for others to recapitulate. Rothschild tea was the standard for quality in Mincing Lane for over twenty-five years.
Breast cancer resistance protein (BCRP) is a member of ATP-binding cassette (ABC) transporter proteins whose primary function is to efflux substrates bound to the plasma membrane. Impaired intestinal barrier functions play a major role in chronic low-grade inflammation (CLGI)-associated obesity, but the regulation of BCRP during obesity and its role in maintaining the intestinal barrier function during CLGI-associated obesity were unknown. Using several approaches, including efflux assays, immunoprecipitation/-blotting/-histochemistry, paracellular permeability assay, fluorescence activated cell sorting, cytokine assay, and immunofluorescence microscopy, recent studies suggest that obese individuals have compromised intestinal BCRP functions and that diet-induced obese mice recapitulate these outcomes. It was also demonstrated that the compromised BCRP functions during obesity were due to loss of Janus kinase 3 (JAK3)-mediated tyrosine phosphorylation of BCRP.
A major focus of the group is on understanding the physiologic significance and control of targeted lymphocyte trafficking. To this end, they are studying the specialized homing mechanisms and functional properties of tissue infiltrating lymphocytes involved in local immune, autoimmune and regulatory responses in the GI tract (intestines, liver), skin, lungs, and other sites. Genetic, antibody and small molecule-based approaches allow them to define the role of trafficking molecules and mechanisms in models of autoimmune and infectious diseases. The team is also exploring mechanisms that imprint lymphocyte homing and chemokine receptor expression during tissue-specific immune responses, and are developing techniques to recapitulate such regulation in vitro for cell targeting and therapy. Dendritic cells (DC) play an important role in this context, and they are interested in the mechanisms by which specialized DC “interpret” and process local environmental signals (e.g.
He toured all over Maharashtra and visited each and every village to collect copies of whatever the spiritual disciples and followers of Tukaram had noted down from his Abhangs. He made people recite the Abhangs, they had memorized and wrote them down. Santaji being the original writer of the Manuscript of Tukaram’s Gatha, it was easier for him to recapitulate the Abhangs from his memory. Thus by undertaking the laborious duty of putting bits together, he recreated Tukaram’s Gatha as recited by Tukaram and gave it a rebirth. This was the second edition of the ‘Gatha” rewritten by the original writer Santaji. Tukaram’s Gatha” lost under the waves of lndrayani, rose again to take its rightful place in the hearts of the sea of masses not because of the blessings of Goddess Saraswati alone, but due to the painstaking efforts and boundless devotion and endeavour of Santaji.
One of his more recent innovations is the creation of tiny, complex, three-dimensional models of living human organs, known as "organs-on- chips" (Organ Chips), which mimic complicated human organ functions in vitro as a way to potentially replace traditional animal-based methods for testing of drugs and toxins. The first human Organ Chip, a human Lung Chip, was reported in Science in 2010. Created using microchip manufacturing methods, the Lung Chip is a complex three-dimensional model of a breathing lung that incorporates living human lung alveolar epithelial cells interfaced with endothelial cells within microfluidic channels cast in silicone rubber, which recapitulate structure and function of the tissue-vasculature interface of lung alveolus (air sacs). In 2012, Ingber and his team demonstrated in a study in Science Translational Medicine the ability to mimic a complex human disease on the Lung Chip — specifically pulmonary edema, known commonly as “fluid on the lungs” — and to identify new therapeutics using this model.
This model was the first to recapitulate all three key AD pathological hallmarks in vitro, and first to definitively show that amyloid plaques directly cause neurofibrillary tangles. The 3-D model also made drug screening for AD faster and more cost-effective. Using this system, Dr. Tanzi has developed several novel therapies for AD including gamma secretase modulators targeting amyloid pathology, ALZT-OP1 targeting neuroinflammation and a neuroprotective drug combination, AMX0035, which was successful in a clinical trial of ALS. Dr. Tanzi also discovered that beta-amyloid plays a functional role in the brain as an anti-microbial peptide, supporting a role for infection in AD pathology. Dr. Tanzi serves as Chair of the Cure Alzheimer’s Fund Research Leadership Group and numerous advisory and editorial boards, He has published roughly 600 research papers and has received the highest awards in his field, including the Metropolitan Life Foundation Award, Potamkin Prize, Ronald Reagan Award, Silver Innovator Award, the Smithsonian American Ingenuity Award, and the Brain Research Foundation Award. In 2015, he was named to TIME magazine’s list of TIME100 Most Influential People in the World.

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