Eight of of these received Orphan drug designation (the cutoff to qualify for Orphan status is 200,21625 patients per year).
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In 2017, the average annual cost per patient of the top 100 orphan drugs — excluding blockbusters with additional orphan uses — was $147,308, while the average cost for the top 100 non-orphan drugs was $30,708, according to EvaluatePharma.
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S. FDA GRANTS ORPHAN DRUG DESIGNATION TO GLEPAGLUTIDE FOR THE TREATMENT OF SHORT BOWEL SYNDROME * FDA OFFICE OF ORPHAN PRODUCTS DEVELOPMENT HAS GRANTED AN ORPHAN DRUG DESIGNATION TO GLEPAGLUTIDE Source text for Eikon: Further company coverage: (Gdynia Newsroom)
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That's because in 1983, Reagan signed into law the Orphan Drug Act, creating significant financial incentives for the development of orphan drugs.
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National health insurance was the orphan of the New Deal, and people are still trying to get the orphan placed with the family.
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Busting the backlog on orphan designations: Exciting scientific advances have led to a doubling of requests for orphan drug designations compared to five years earlier.
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The security package supports the orphan SPV's loan to T&R Group, with the benefits passed indirectly from the orphan SPV to the senior secured creditors.
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In the resulting 6900 years, over 2628 orphan therapies have been developed for rare diseases compared to the only 28503 orphan therapies in existence prior to 22019.
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Since its creation, more than 3,500 potential treatments have received orphan drug designation, and more than 500 orphan therapies have been approved by the Food and Drug Administration (FDA).
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Read more:The Ukrainian orphan accused of being an adult was found living with another family in IndianaA Ukrainian orphan at the center of an adoption scandal might be an adult.
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" She continues: "I felt like a runaway, an orphan.
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"Orphan Black" ended its five-season run back in 2017, but Serial Box is currently continuing the story with "Orphan Black: The Next Chapter," a weekly series of e-books and audiobooks.
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Orphan Black is back on BBC America on April 14.
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The Orphan Master's Son by Adam Johnson was really great.
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Graeme Manson (Orphan Black) is overseeing the series, which stars.
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Spoilers ahead for all of Orphan Black except the finale.
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Orphan Black's series finale airs August 12 at 10 p.m.
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Orphan crops have yet to undergo such a genetic revolution.
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Who knew that Ferdinand would become Orphan Black's comic relief?
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Helen was an orphan whose parents had died of AIDS.
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The orphan was likely separated from his mother by force.
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There's Akira, an Indian street orphan who's formidable with spices.
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JiaJia, the Chinese orphan waiting for them, can't sleep either.
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IMHO: Is Miss Havisham OkayLMAO: Love to Mistreat An Orphan!
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Victoria Orphan, 44 Geobiologist California Institute of Technology Pasadena, Cal.
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She knew it would leave her only daughter an orphan.
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Lance Corporal Gutiérrez grew up as an orphan in Guatemala.
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Is there any more classic underdog than the Victorian orphan?
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Homer is an orphan; his several adoptions don't work out.
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Victory has a hundred fathers and defeat is an orphan.
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The bride is an orphan, her parents, Mr. (3) 3.
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STOCKHOLM (Reuters) - Swedish drug maker Swedish Orphan Biovitrum (Sobi) (SOBIV.
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Success has a thousand fathers, but defeat is an orphan.
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Orphan Black airs Thursdays at 10 pm on BBC America.
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"Today, the French cinema wakes up an orphan," Riester said.
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It was around, it was not an orphan life, essentially.
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If it's not already clear, Orphan Black is incredibly ambitious.
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In the end, it'll be up to insurance companies and providers to decide whether an orphan approval makes a biologic more desirable than a biosimilar, even for the non-orphan uses that drive most sales.
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Sounds like a film version of cult favorite series 'Orphan Black.
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He lives at the orphan wildlife center in New York state.
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Prior to Wednesday's order there were 1,590 orphan wells in Alberta.
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And that if anything happens to her, Franny becomes an orphan.
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Tatiana Maslany, Orphan Black Outstanding Supporting Actor in a Drama Series
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As a young orphan, she's a disposable tool to them both.
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By the time Marks reached Canada, she was practically an orphan.
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It's Dory, rendered an orphan by her short-term memory loss.
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Rey wears the cheap, desert-ready clothes of a resourceful orphan.
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The gunman didn't kill Gage, but instead left him an orphan.
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Lyra, who is an orphan, is invited up North by Mrs.
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" Dozens of widely used medicines have won designation as "orphan drugs.
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Wander is an orphan, a fallen seminarian, a movie-theater owner.
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Then, in 2000, Mom died and I became a Thanksgiving orphan.
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Only a little over a year old, orphan from egg crack.
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I, too, was an orphan and was later adopted at 7.
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Would no one from the blighted orphan world have crossed back?
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STOCKHOLM (Reuters) - Rare disease drug maker Swedish Orphan Biovitrum (Sobi) (SOBIV.
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STOCKHOLM (Reuters) - Rare disease drug maker Swedish Orphan Biovitrum (Sobi) (SOBIV.
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This "natural history" model will help reviewers boost orphan drug development.
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"If you lose your parents, you become an orphan," he said.
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Kline's previous novel, "Orphan Train," also emphasized lives forged in hardship.
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"Little Orphan Annie" was released in 1932 and remade in 1938.
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David Fajgenbaum: Advances for rare or "orphan" diseases occur completely randomly.
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He's a white guy, but he was an orphan, abandoned, destitute.
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As any good member of the Clone Club knows, the only thing nearly as fun as new episodes of Orphan Black is talking about Orphan Black and now, BBC America is making a show about it.
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The ODTC was originally created in 22019 as a part of the Orphan Drug Act (ODA), and is a major incentive for the development of drugs for patients with rare diseases, also known as orphan drugs.
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But Kristine Barnett says they were scammed in a situation eerily similar to the plot of the horror movie "Orphan," in which a mentally disturbed adult poses as an orphan who's taken in by a vulnerable family.
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Because Force powers can spring up in anyone, even a Jakku orphan.
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No actress on television works harder than *Orphan Black'*s Tatiana Maslany.
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The Checkup To my great and continuing surprise, I am an orphan.
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So I am turning 60, and I think about being an orphan.
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Literature's most well-known orphan is heading to the small screen — again.
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In the BBC America series Orphan Black, audiences got a little spoiled.
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Ruth and Nat, another orphan, claim they can speak to the dead.
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Singer-songwriter Ashley Monroe's track "Orphan" is one of her most personal.
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How did the track "Orphan" come to be in the first place?
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Perhaps she was an orphan and maybe she didn't have any family.
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You have to love the story of an orphan made good, right?
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She is a porcelain-skinned orphan virgin and that's all I know.
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Possibly becoming an orphan — or so he recently joked with this pic.
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She's a cultural orphan, split by her parents' racial shame and recriminations.
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Kai is a tough orphan from the provinces and a gifted pianist.
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A. is an orphan in an institution of orphans supervised by Goodman.
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This will orphan programs that bolster both farmers' and consumers' safety nets.
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If it makes some uncomfortable, that's no accident—it's pure Orphan Black.
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"It's kind of an exciting time with the sequencing technologies," Orphan said.
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After the war, she'd worked as an instructor in the orphan village.
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Still, the confusion illustrated the orphan nature of the sport in Crimea.
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Parents are asking questions like, 'Do I have to orphan my child?
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Moshfegh's sentences are piercing and vixenish, each one a kind of orphan.
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The past decade alone has brought a record 250 orphan drug approvals.
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"I have an orphan psychology, that's what I've been told," she said.
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Please do not repeal, or substantially weaken, the Orphan Drug Tax Credit.
|
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The issue has been something of a political orphan in recent years.
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He was an orphan serving four years for shoplifting food to eat.
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|
Some experts fear, however, that even once there's a competitive biosimilars market in the U.S., these orphan approvals will give biologics a leg up — even though these orphan approvals don't legally bar biosimilars from competing on other uses.
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|
The agency plans to respond to orphan drug applicants within 90 days of receiving an application and establish an Orphan Products Council to help ensure the FDA is applying a consistent approach to regulating and reviewing these products.
|
|
But Kristine Barnett says her family was scammed in a situation eerily similar to the plot of the horror movie "Orphan," in which a mentally disturbed adult poses as an orphan who's taken in by a vulnerable family.
|
|
The annual growth rate of orphan drugs between 2019 and 2024 is forecast to be 12 percent—approximately double that of the non-orphan market, according to EvaluatePharma's 2019 report of the top 73 pharmaceutical and biotech companies.
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Orphan Black: The Next Chapter is the latest such foray into existing worlds.
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And the story of the Colored Orphan Asylum seems too important to forget.
|
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They're never just about a king, or an orphan girl, or a monster.
|
|
But when Orphan Black is good, it's a laser-focused, hyper-imaginative gem.
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|
So why does it feel surprising to me, that I am an orphan?
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|
Horizon makes drugs to treat ailments that include arthritis, inflammation and orphan diseases.
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|
The company was also granted orphan drug status by the EU on Tuesday.
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|
Brit, the orphan who longs for connection but will settle for her violin.
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ALBEIT SMALLER ASSETS, WE ANNOUNCED THE SALE OF RUCONEST, AN ORPHAN DISEASE PRODUCT.
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It tells the story of a rambunctious 11-year-old orphan, Anne Shirley.
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This is the first implementation of orphan works authorization in US copyright law.
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Orphan Black just went full on Game Of Thrones, and I'm loving it.
|
|
The stranger knew what they were doing, and Orphan of Kos quickly fell.
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|
You also may know her as Cosima, another main character in Orphan Black.
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|
The many narratives of Orphan Black are at last coming to an end.
|
|
If you did the whole thing medium ... You'd look like an orphan. Yes.
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|
The Orphan Drug Act of the 1980s, for example, spearheaded by former Rep.
|
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Even if you haven't watched Orphan Black, you've probably heard about Tatiana Maslany.
|
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In 18th-century Cairo, streetwise orphan Nahri cons wealthy Ottoman tourists to survive.
|
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Before Rod, Nacho'd been another orphan junkie working the Latin bars on Washington.
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|
Although, Abigail only had a small cameo as an orphan in that one.
|
|
"Orphan: The Quest to Save Children with Rare Genetic Disorders" by Phil Riley
|
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How all this might play out is still an "open question," Orphan said.
|
|
When Luz meets Jonah, an orphan, the lonely teenagers connect spiritually, then sexually.
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The only one I can think of is Annie, or LITTLE ORPHAN ANNIE.
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"If you lose your father they call you an orphan," the father laments.
|
|
Roman Abramovich was an orphan — now he owns the world's third-largest yacht.
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Since then, the trickle of orphan removals has remained steady but still slow.
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|
We're introduced to teen orphan Cass via Black Canary, who is her neighbor.
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" It later morphed into "Success has many fathers, but failure is an orphan.
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Season 4 of the thrilling sci-fi series "Orphan Black" arrives on Amazon.
|
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She might have seen herself in the orphan girl alone in the city.
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I had my father and mother, but I was an orphan without them.
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|
After some concern that the drug's "orphan drug" status, might lead the cost remdesivir to sky-rocket, Stat reported on Wednesday that Gilead asked the FDA to rescind their orphan drug designation, and is "waiving all benefits that accompany" it.
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|
Phil says he doesn't think the Ukrainian orphan accused of being an adult knows her own ageThe Ukrainian orphan at the center of an adoption scandal says she's a teenager, and none of her adoptive parents' claims are trueA woman who claims she's the Ukrainian orphan's biological mom says the girl is a child A Ukrainian orphan at the center of an adoption scandal might be an adult.
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" He continues, "Orphan care is close to my heart because I was once one.
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"Rare/orphan diseases, by definition, have catastrophic consequences for the families affected," he said.
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Bernie Sanders has called out individual pharmaceutical companies for raising prices on orphan drugs.
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The story follows a young orphan and Halliday scholar named Wade Watts (Tye Sheridan).
|
|
It's a full Orphan Black reunion, complete with Beach Boys playing in the background.
|
|
In Orphan Black, much like in the real world, nothing is clean and simple.
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|
AXAL has Orphan Drug Designation in the U.S. for the treatment of anal cancer.
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Doing so will orphan your original Bungie account with no method to log in.
|
|
" There's an old saying: "success has a thousand fathers, but failure is an orphan.
|
|
Once he arrived at LWC, the sweet orphan started receiving around-the-clock care.
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Now that Gilbert is also an orphan, Anne feels a certain kinship with him.
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He had worked with refugee and orphan children around the world as a humanitarian.
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She's an orphan who goes on a grand quest to uncover her royal heritage.
|
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The bidding on licenses in the West Orphan Basin will close on Nov. 9.
|
|
Critics have long complained that drugmakers game the FDA's approval process for orphan drugs.
|
|
Gage is now an orphan and has lost the grandparent who had mothered him.
|
|
By age 16, after his father had died of typhus, he was an orphan.
|
|
Watson believes the bastard orphan is Gryffindor; Radcliffe thinks he's Ravenclaw, according to Miranda.
|
|
Seven of the 10 top selling drugs in the United States have orphan status.
|
|
I'd never felt so relieved to be the only full orphan in the room.
|
|
Editorial Success has many fathers, the old saying goes, while failure is an orphan.
|
|
The company's decision to seek orphan status for the drug had drawn immediate criticism.
|
|
It was a shaky situation for a young orphan: His brother drank and partied.
|
|
Alexander Hamilton in founding the New York Orphan Asylum at Barrow and Fourth Streets.
|
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He is thrust into the world effectively an orphan, a foreigner in every home.
|
|
He was not an orphan: he remained close with his mother and his brother.
|
|
Without the ODTC, approximately one-third fewer orphan therapies will be developed going forward.
|
|
She's an orphan, and he's the only one in the world who knows why.
|
|
Samantha Parkington is an orphan living in New York City during the early 1900s.
|
|
It was only a matter of time before Orphan Black had to address eugenics.
|
|
Campaigners and pharmaceutical companies hope the new list can begin to change that, as the Orphan Drug Act of 1983 did in the United States, leading to the approval of more than 600 'orphan' drugs and incentives for firms to develop more.
|
|
But Orphan Black had proved to executives that a noisy fandom — the #CloneClub, to use the Orphan Black parlance — could cut through the din of Peak TV, in which a show can easily come and go from television without anyone even noticing.
|
|
The U.S. Court of Appeals for the District of Columbia Circuit by a 2-1 vote held the Orphan Drug Act entitles drugmakers to the marketing exclusivity period if the FDA designates a medication as an orphan drug and later approves it.
|
|
The star of Orphan Black believes that talking about other people's bodies is completely unnecessary.
|
|
More local firms, too, are weighing up the 'orphan' drug market, though most remain wary.
|
|
Forget about monsters under your bed — on Orphan Black, the monsters are implanted inside you.
|
|
Orphan Black's science consultant, Cosima Herter, believes that cloning humans is illegal in North America.
|
|
Even without traditional television success, Orphan Black stood out as a smart, well-made series.
|
|
An orphan raised by the Shakers, he did not choose this life or its restrictions.
|
|
Treating a specific subtype of cancer, for example, is one way to win orphan status.
|
|
This is her second nomination for her role on Orphan Black, and her first win.
|
|
And then, Bruce unwittingly adopts an orphan, Dick Grayson (Michael Cera), who, yes, becomes Robin.
|
|
The assumption, genuine or otherwise, that a child is an orphan makes them especially vulnerable.
|
|
Forty-one percent (nine of the 22 drugs) are intended for orphan or rare diseases.
|
|
HOW MUCH WILL IT RELY ON THE ORPHAN DRUG LAWS THAT EXIST IN THIS COUNTRY?
|
|
Since 1983, the orphan drug credit has helped more than 500 drugs come to market.
|
|
In 28500, Congress passed the Orphan Drug Act to incentivize therapeutic development in rare diseases.
|
|
In reality, Gignac is an orphan who was adopted by a Michigan family in 2023.
|
|
My novel "Orphan Train" — set, in part, on Mount Desert Island — was an unexpected success.
|
|
They make welcome meta-jokes such as that all middle-grade novels require an orphan.
|
|
Like all good heroes, Sarman is an orphan (he lives with his aunt and uncle).
|
|
An acquaintance, Jane Aronson—a pediatrician who calls herself the Orphan Doctor—had contacted her.
|
|
But before we explore Orphan Black 's legacy, let's get into the real dirt: spoilers.
|
|
" 'ORPHAN CHILD' (1830s) "I started thinking about when people were on that Trail of Tears.
|
|
Meet Pavitr Prabhakar, an orphan living with his Aunt Maya and Uncle Bhim in Mumbai.
|
|
" He declared, "The right to keep and bear arms is apparently this court's constitutional orphan.
|
|
His friend Turner, a street-savvy orphan, thinks Elwood's idealism is misguided and hopelessly naïve.
|
|
Maybarduk said that Gilead was "under great public pressure" to revoke the FDA's orphan designation.
|
|
"Orphan Black" often would incorporate bits of dialogue that fans became obsessed with into scripts.
|
|
But at the same time, she was infantilized as "la petite orpheline," the little orphan.
|
|
Adri, a 16-year-old orphan, is training to join a team heading to Mars.
|
|
"It's almost as if she'd been an orphan," a friend, Isabel Rattazzi, said by phone.
|
|
The 1983 Orphan Drug Act is a model for bipartisan compromise and sound healthcare policy.
|
|
"The right to keep and bear arms is apparently this court's constitutional orphan," he wrote.
|
|
"Here's the bad news — I'm a widow, an orphan, and an empty-nester," she said.
|
|
"The right to keep and bear arms," he said, "is apparently this Court's constitutional orphan."
|
|
Or pretend that she had any claim to her, this orphan from the Iron Age?
|
|
She wasn't about to turn an orphan from the Iron Age out on the street.
|
|
As a Chicano orphan reared by the foster and prison systems, that is his fate.
|
|
The reason that this study is especially important to the rare disease patient community is that the false assertions about the high cost of orphan drugs to the health care system has led some to call for major undermining of the Orphan Drug Act (ODA).
|
|
We watch as she goes from happy kid whose parents won't let her watch the blaxploitation film Sister Night, to an orphan, to somehow even worse than an orphan when the grandmother who shows up to take her in dies almost immediately after meeting her.
|
|
Asta is an orphan from the poorest outskirts of a kingdom in a magical fantasy world.
|
|
Sure enough, the loving avians took turns sitting on the orphan egg until it finally hatched.
|
|
Lee desperately trying to prepare the orphan Clem for the brutal realities of life without him.
|
|
Lil Bub, a rescued orphan kitty with an extreme case of dwarfism, is an internet sensation.
|
|
To read more about the trust's orphan elephants and the process of raising them, click here.
|
|
With the end of Orphan Black comes the end of a decently plausible science fiction series.
|
|
Like the Prophet Muhammad, he was an orphan, and, he says, "felt the pain of poverty".
|
|
Sarah's related to Kendall and now S, so he's really the only orphan in the family.
|
|
In addition to Kidman, the movie stars Sebastian Stan, Bradley Whitford, and Orphan Black's Tatiana Maslany.
|
|
Even with orphan programs at risk, agriculture committee leaders are hopeful a solution will be found.
|
|
Because the conditions are so rare, GW Pharmaceuticals has received an orphan drug designation for Epidiolex.
|
|
TSC is the third orphan indication that GW is targeting within its Epidiolex clinical development program.
|
|
His mother and two brothers died during the Revolutionary War, leaving Jackson an orphan at fourteen.
|
|
Bleak and barren is the moor / The orphan girl she sheds a tear / And thinks of
|
|
He adopted his orphan niece, Harriet Lane, and appointed her to handle the First Lady's business.
|
|
The final boss in Bloodborne: The Old Hunters, the grotesque Orphan of Kos, is a bastard.
|
|
You may know Tatiana Maslany as Sarah Manning, the main character of BBC America's Orphan Black.
|
|
To watch Orphan Black live on BBC America online, you'll need TV credentials to log in.
|
|
LOCAL UTILITIES' predictable businesses and steady dividends have earned them the moniker "widow-and-orphan shares".
|
|
In turn, there could be a "richer incentive" for drug companies to go after orphan approvals.
|
|
The Ukrainian orphan accused of being an adult was found living with another family in Indiana
|
|
Guerdwich Montimere, 21, posed as a 16-year-old Haitian orphan to play basketball in Texas.
|
|
But Mr. Cruz has good reason to focus on what might be called Tuesday's orphan states.
|
|
The Tennessee Titans, an orphan franchise waiting for real ownership and direction, were never a threat.
|
|
Maester Pycelle: Brutally stabbed to death by Qyburn's — formerly Varys' — little birds, aka orphan street children.
|
|
Raised as an orphan in a Buddhist monastery in Thailand, Ek learned the power of meditation.
|
|
She's an orphan with too much debt, too little sleep and no love in her life.
|
|
However, before he landed on Forbes' Billionaires List, he was an orphan growing up in Moscow.
|
|
They discovered it crying alone on the forest floor, and guessed that it was an orphan.
|
|
Everything we know about the bizarre case of the Ukrainian "orphan" who may be an adult.
|
|
The House bill eliminates the orphan drug credit while the Senate bill cuts it in half.
|
|
Now his father passed away and the FBI came in and basically made him an orphan.
|
|
Like Jane Eyre, she is a penniless Victorian orphan, and Jane Eyre is her favorite book.
|
|
Read more:The Indiana couple accused of abandoning their adopted Ukrainian orphan daughter say they fear for their lives nowA woman who claims she's the Ukrainian orphan's biological mom says the girl is a childA Ukrainian orphan at the center of an adoption scandal might be an adult.
|
|
Children were taken from inner city slums, put on "orphan trains," and shipped West to be adopted.
|
|
He was an orphan, which was the teen dream of freedom realized...and a little bit scary.
|
|
Dispense justice for the needy and the orphan, for they have no one but their fellow citizens.
|
|
It's billed as a musical adventure comedy about an orphan girl who aspires to become a dancer.
|
|
Orphan Black lost some viewers last season as it kept burrowing ever deeper into its own mythology.
|
|
A woman called Marilyn Noble gave Widman the manuscript for a memoir called Orphan Girl No. 58.
|
|
In the comics, he's a corrupt cop who killed an orphan who Poison Ivy was looking after.
|
|
But drawing is not the orphan child of painting; it is a deep, material way of working.
|
|
Orphan Black explores this taboo by giving us villains that love experimenting on unwilling or unwitting people.
|
|
She's an orphan (her mother died in a plane crash, and her father died at his desk).
|
|
An orphan who spent his life perfecting an environment where people could feel safe, dance and smile.
|
|
Over the following years I passed through the arms of all accepted trends like a cultural orphan.
|
|
He was then a destitute war orphan living in a fly-blown refugee camp in northern Kenya.
|
|
They invent outrages, such as the rape by German NATO soldiers of a non-existent Lithuanian orphan.
|
|
Ware also shared the backstory of one particular orphan, Gerhana, who is only about one year old.
|
|
The film also stars Orphan Black's Tatiana Maslany, Bradley Whitford and Avengers: Infinity War actor Sebastian Stan.
|
|
Such a boy often was referred to as a prikkenbijter (lamprey biter), and often was an orphan.
|
|
Clearly, everyone knows about the parental murders that turned Bruce Wayne into the world's moodiest billionaire orphan.
|
|
" You know the one: "DUN dadada da DUN doo doo doo how does a bastard, orphan [etc.].
|
|
No amount of preparation can ready a child to be an orphan by the age of eight.
|
|
The orphan was starving, suffering from a severe parasite infection, couldn't keep herself warm, and having seizures.
|
|
The orphan has no understanding of women, and so he is powerless to resist Rachel's searching face.
|
|
One grew up an orphan and impoverished; the other was gifted with generational wealth by his father.
|
|
Both treatments also received orphan drug designation, a status granted to drugs for rare diseases or conditions.
|
|
His mother-in-law had reproached his wife more than once for getting engaged to an orphan.
|
|
This means that pharmaceutical companies could have fewer incentives to keep producing orphan drugs for rare diseases.
|
|
A tragic crash during the evacuation of orphan refugees from South Vietnam in 222 killed 223 people.
|
|
Children placed on "orphan trains" were offered for adoption at depot stops and churches along the way.
|
|
It has been granted orphan status, which comes with several extra years of marketing exclusivity if approved.
|
|
Brontë began Jane's story in her miserable childhood, as an orphan raised by a spiteful, abusive aunt.
|
|
Characters refer to far-flung locations like "Constantinople" and ten-year-old orphan boys can have jobs.
|
|
It follows an orphan who joins a battle to keep a fantastical kingdom safe from various threats.
|
|
For much of its 100-year existence the PGA Championship has been the orphan of golf majors.
|
|
David F. Sandberg directed the sequel about a dollmaker whose creation terrorizes a group of orphan girls.
|
|
But there's this maternal aspect that makes it a little dangerous, because Tess is essentially an orphan.
|
|
When we meet the Jedi Master on Ahch-to, he's basically an orphan boy all over again.
|
|
Op-Ed Contributor According to an old proverb, success has many fathers, but failure is an orphan.
|
|
He was raised an orphan after both his parents died in concentration camps during World War Two.
|
|
While adopting a war orphan in Europe was exceedingly difficult, obtaining a visa was almost unheard-of.
|
|
With the final season's villains trying to procure Kira's eggs, Orphan Black's entire narrative comes full circle.
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"Apparently, without hesitating, I said, 'Well, you'll just be an orphan then,' and moved on," she said.
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The proposal under consideration would end the tax breaks for development of what are called orphan drugs.
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Lasse Hallstrom directs this tale of a New England orphan based on the novel by John Irving.
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She writes: I arrived on my mother's back language's orphan, a two-citizen child with no country.
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He was 403-foot-4, Texas-born, an only child and an extremely rich orphan at 19.
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The good news is, I have the freedom of a widow, an orphan and an empty nester.
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An orphan from a poor neighborhood, she said a D.J. had invited her to a pamper party.
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Swedish Orphan Biovitrum shares jumped around 9% after the company raised its full-year estimates for 2019.
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Robot" and "Orphan Black, is the stuff of awards season glory — or, at least, water cooler debates.
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My grandmother was an orphan herself—her parents died in an epidemic in the early twentieth century.
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"Annie" hit the big screen again in 2014 starring Quvenzhane Wallis as the rags-to-riches orphan.
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Known as "orphan" wells, these one-time hopes for black gold are left deserted by corporate profiteers.
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Marie knows that the hummingbird has been left there by Tristan, an orphan boy she secretly loves.
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As Vox's Matt Yglesias wrote, Bush is a sort of "political orphan" whose achievements are often overlooked.
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Every orphan that enters our facilities has a unique story, but most of their plights stem from deforestation.
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It's been 25 years since Alisan Porter graced the big screen as the curly-haired, pint-sized orphan.
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AstraZeneca — The company's cancer drug selumetinib has been granted "orphan drug" status by the Food and Drug Administration.
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One of those stocks is BioMarin, one of the leading makers of orphan drugs that treat rare diseases.
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On the surprise release front, the service will also premiere the Orphan Black-esque What Happened to Monday?
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With BioMarin on the company's plate, Roche would get a more diverse portfolio in the orphan drug business.
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"We said, 'Let's pretend this DNA is an orphan and is trying to find its daddy,'" Hampikian said.
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"I don't think that that was by mistake that we start with an orphan [her character]," King says.
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In Europe, Swedish Orphan Biovitrum shares rallied 10% after the company forecast full-year profit and sales growth.
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Occasionally found at farmers markets, it's known as an "orphan crop," a plant too finicky for mass production.
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Now Cersei is childless and an orphan, and when we last saw her, she claimed the Iron Throne.
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Soon they realized that Little Orphan Annie was also acting extremely protective of a certain patch of road.
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He has had credits on Fresh Off The Boat, Orphan Black, Slasher and Bad Blood among other series.
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The rescues range from puppies, mother dogs that recently gave birth, pure breeds, mixed breeds and orphan pups.
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The goal will be to eliminate a backlog of 200 orphan drug designation requests, starting with the oldest.
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For more kitty sweetness and orphan-rearing tricks of the trade, follow Kitten Lady on YouTube or Instagram.
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The success of that promotion inspired a free Friday for Orphan Black's first season later that same year.
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Along for the ride is an orphan with special powers, M.K. (Aramis Knight), who repeatedly crosses Sunny's path.
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"The right to keep and bear arms is apparently this court's constitutional orphan," he wrote in a dissent.
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Repealing or cutting the orphan drug tax credit undermines the hope that a treatment or cure is possible.
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One idea would be to lower that number, meaning orphan designation goes to treatments for even rarer conditions.
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No, it's not that Mr. Trump espouses the biblical virtues of helping the widow, orphan, stranger and poor.
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Questcor was asking the FDA to make it official as part of an application for orphan drug status.
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As if she were alone and on an adventure, the resourceful orphan, and Andrew was the tracking shot.
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GAO analysts examined FDA records for 148 applications submitted by drugmakers for orphan drug approval in late 2017.
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BBC America's mind-bending Orphan Black is returning for another season of clone wars and scientific self-discovery.
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We love this concept of orphan characters trying to save the universe, the team had to work together.
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Scientists named this idea "orphan memory" in a paper published this month in the journal Physical Review Letters.
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He's an orphan, who grows up with his cash-strapped aunt and uncle in a lower-class neighborhood.
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It's about an orphan girl who grows up in a house run by a woman who holds séances.
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Mallinckrodt – The drugmaker's experimental muscular dystrophy treatment was granted "orphan drug" status by the Food and Drug Administration.
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Over 100 years ago, Coco Chanel transformed herself from peasant orphan into the founder of a fashion empire.
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There were passing parallels between Little Gloria and Little Orphan Annie, with whom she identified all her life.
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But life as a medical aberration remains daunting, because there is no instruction booklet for this orphan disorder.
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She then came back in the 2016 comic, Batman & Robin Eternal, yet again with another new identity: Orphan.
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In the good news category, Wu points to the increased number of orphan drugs that have been approved.
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"At this price Daraprim is still actually on the low end of what orphan drugs cost," Shrkeli said.
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This is partly because of a lack of information on orphan works, but it also has its benefits.
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Their orphan progeny will then return to the ground and will live the next 17 years in silence.
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Orphan studies anaerobic microbes—organisms that don't require oxygen for respiration—in methane seeps on deep ocean floors.
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Arguello (played by Benjamin Wadsworth) is an orphan who blames the death of his parents on Ronald Reagan.
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Dmitriyev, himself an orphan, adopted the girl when she was 3 after his two biological children had grown up.
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In the story, an orphan named Nicholas is lured into a magic valley populated by artisans and toy makers.
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The breakthrough drug also received orphan drug status from the FDA, meaning it has seven years of market exclusivity.
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But despite nearly 800,000 DREAMers who signed up for it, DACA was a political orphan in Trump's White House.
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Orphan Black newcomer Tatiana Maslany and husband Tom Cullen looked so in love, we couldn't get enough of them.
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My three mothers Many of the memories I have of Kolkata and living as an orphan are a nightmare.
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It was about a group of orphan children who find themselves in a candy store; the candy was evil.
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BUT THERE ARE MORE OPPORTUNITIES IN THE ORPHAN OR RARE DISEASE AREA THAN IN ANY OTHER AREA OF HEALTHCARE.
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Fortunately, The X-Files' popularity ensured it would have successors — Black Mirror and Orphan Black come immediately to mind.
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During her tenure, she performed in several recurring bits, one of which involved a lascivious grown-up Orphan Annie.
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In "Mustang", the Turkish-French Deniz Gamze Ergüven takes on patriarchy from the perspective of five adolescent orphan sisters.
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If approved, the new gene therapy would be another victory for combating rare diseases, also known as orphan diseases.
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At the end of "Kung Fu Panda 2," we learned that Po (Jack Black) wasn't an orphan after all.
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Not only are viewers questioning the general theories of Orphan, they're questioning what the final few seconds will reveal.
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Hint: Her next role is still every bit as intense as the ones she took on in Orphan Black.
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And yet, his legacy that touches the most lives may be in healthcare, specifically, the 22019 Orphan Drug Act.
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The company's tactic was criticized as an attempted abuse of the Orphan Drug Act, including by the F.D.A. itself.
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About 22008 percent of the drugs given orphan status were intended to treat diseases affecting fewer than 1383,2138 people.
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"We have accepted culturally that it's OK for a company to charge high prices for [orphan] drugs," said Roy.
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The U.S. Food and Drug Administration has granted orphan status to AMG510 for KRASG12C-positive NSCLC and colorectal cancers.
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Guerdwich Montimere spent two years in prison after posing as a teenaged Haitian orphan to play basketball in Texas.
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"Orphan Black," about a woman who discovers she's a clone, isn't action heavy, but there is some action certainly.
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Tatiana Maslany gets even more exposure as "Orphan Black" begins a new season with a new night and time.
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Your contribution could make all the difference in this sweet orphan animal's regular care, healthy progress and continued growth.
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An orphan raised in the West Indies, he was the only self-made man in a galaxy of patricians.
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Not while growing up as an orphan in his village near Lake Victoria where everybody was, like him, black.
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Delille has created spare tableaux that suggest the girl's evolving physicality, from a prowling beast to a rescued orphan.
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Ruth Saperstein Jaffe with evidence of her former life as Bela Raphael, the orphan saved by Sergeant Bert Simons.
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The film follows Ren, a young Japanese orphan who finds a portal to a world filled with humanoid animals.
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With her mother struggling to support them, "I felt like I was an orphan," Ms. Solts, now 72, recalled.
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We cooked dinner, talked, watched a few episodes of 'Orphan Black,' slept, then cooked breakfast and talked some more.
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In terms of upcoming projects, Leland will be playing Frank Smith in "The Orphan Train" and Colt in "Land."
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He emerges from the field a dirty, sweaty orphan, more fit for a Charles Dickens novel than modern society.
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In 2014, 40 percent of all approved new drugs were orphans; in 2015, 85033 percent were orphan drugs. 5.
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In a word: France today is an orphan, bereft of the two conflicts that long drove its political life.
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Cain has since dropped the Batgirl name, fighting crime with the names Kasumi, the Black Bat and, currently, Orphan.
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Your fellow churchgoer has accused you of poor judgment and smelling bad while comparing you to a starving orphan.
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But some come in the form of orphan radio stations, junked cars, unwanted boats or collections of baseball cards.
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The inescapable conclusion of the study is that orphan drugs are not a major factor in health-care spending.
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Of total drug sales of $22019 billion in the U.S. in 2016, only 7.9 percent was for orphan drugs.
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Second, for the particularly R&D-intensive biopharmaceutical sector, lawmakers should retain the original orphan drug tax credit rate.
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" Since no one was left to be widowed, I re-named this in my mind as "the orphan maker.
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Additionally, this bill requires adult molecular targeting drugs that receive an orphan designation to undergo such a pediatric investigation.
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The reply you await—handwritten and sealed with wax—is being brought to you by an orphan on horseback.
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An orphan, the only people in her life are her sole friend (who she hates) and her ex-boyfriend.
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You're a rich orphan with a trick jalopy who can't tell the difference between a supervillain and a boat.
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NEW YORK and LONDON, July 2646, 2378 (GLOBE NEWSWIRE) -- Akari Therapeutics (NASDAQ:AKTX), an emerging growth, clinical-stage biopharmaceutical company, announced today that the European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP) has issued a positive opinion recommending orphan drug designation for Coversin for the treatment of paroxysmal nocturnal hemoglobinuria (PNH).
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The game starts off in China, where little baby orphan Shaquille is discovered in a bag floating down a river.
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I'm compelled by the figure of the wanderer without a home, by the orphan (though I have loving parents myself).
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And while the rest of the cast is certainly laudable, Orphan Black has always lived or died on Maslany's performances.
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First, there's the protagonist, Elisa, an orphan who was abused as a child and had her vocal box cut out.
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There are no Jedi in sight, but naturally, Amara is a plucky orphan with hidden talents and a grand destiny.
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Our admirably capable protagonist in Transcription is an 233-year-old orphan drafted to work for M15 as a spy.
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Worried about the dog's well being, the party continued to feed the pup, who they eventually named Little Orphan Annie.
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Much of Maslany's early Orphan Black seasons were plagued by fan frustration that her demanding performances weren't receiving critical recognition.
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"One of my favorite pictures of his is from Lesotho and he's spinning around this young orphan boy," he adds.
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But this one, from Jaume Collet-Serra, the director of Orphan and Unknown, is also "a monster movie," she says.
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Her favorite person in the world is Mija (Ahn Seo Hyun), an orphan living with her grandfather (Byun Hee-bong).
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In 2016 the FDA received 568 new requests for orphan drug designation, more than double the number received in 2012.
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The Walking Dead's Jeffrey Dean Morgan and Orphan Black's Tatiana Maslany presented the award to the first-time Emmy winner.
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Within the pages of his story, Harry was a living example of all my worst fears—an orphan, a survivor.
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Alberta, which produces about 80 percent of Canada's crude, has more than 1,500 orphan wells, up from 26 in 2012.
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For instance, Laufer said that many of the medicines for orphan diseases are made of biological material, such as fungus.
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Congregations have latched onto an estimate by UNICEF that there are 123m orphans in the world, declaring an "orphan crisis".
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This is not, and should not be, a partisan issue; over 200 patient groups support the orphan drug tax credit.
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Every world religion has at its core a commitment to caring for humanity: the orphan, the widow and the stranger.
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Under the Orphan Drug Act, Crestor was granted seven years of protection from generics, but only to treat that disease.
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Into this landscape flies the brave orphan Atari, who has hijacked a puddle jumper in order to search for Spots.
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Celgene's chemotherapy drug Revlimid was the top-selling orphan with $5.4 billion in sales and $184,011 in revenue per patient.
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The drug also received orphan drug designation specifically for its use in treating recurrent epithelial ovarian cancer, the company said.
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Dorothy in The Wonderful Wizard of Oz is an orphan, and so are Huckleberry Finn and Horatio Alger's Ragged Dick.
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Chewbaaka, rescued as a 10-day-old orphan in Namibia, became an "ambassador" animal for the Cheetah Conservation Fund there.
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Not all of them, though; "Aladdin" was among the so-called orphan tales added by Galland on his own initiative.
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As a poor orphan in North Korea, he survived harsh winters by smuggling foreign films across the frozen Tumen River.
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"This was an orphan population," Dr. Mark Kline, the physician in chief at Texas Children's, said in a telephone interview.
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The profound ways orphan-status impacted me in my 20s couldn't compare to the profundity of loss at their age.
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College fraternity brothers, elementary school dropouts and even a raised-by-the-streets orphan, they were whiskey guzzlers and teetotalers.
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Pearl, played by Isabelle Fuhrman ("Orphan"), rationalizes that a shot at a career in film is worth an uncomfortable act.
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Without orphan-drug status, a company like Gilead would receive five years of monopoly protection for a new drug approval.
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Of the 59 new drugs that the US Food and Drug Administration approved last year, 34 were for orphan conditions.
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Many new cancer approvals also receive orphan-drug designation because they are targeted at a narrow slice of the population.
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BBC America executives also saw that "Orphan Black" fans were particularly interested in drawing up art based on the show.
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Her stable of characters also included Fernand, an opportunistic and self-pitying orphan, and Robin les Foies, a lazy detective.
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Getting creative with clinical trials: Orphan drug development is especially challenging because of limited patient populations for required clinical trials.
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In 0003, a repatriated former orphan built a monument in the cemetery to the Chinese parents who adopted Japanese children.
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" O'Brien's first published story, which ran in The Saturday Evening Post , in 20163, was called "An Orphan on the Run.
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He portrayed himself as an orphan in that book, which follows him from upstate New York to his naval service.
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In June, AstraZeneca won seven years of exclusive marketing rights for the new indication under the federal "orphan drug" program.
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By his mid-teens, when Stockhausen was a medical orderly tending to disfigured, dying soldiers, he had become an orphan.
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In September 2015, in her speech at the United Nations, Peng mentioned a 5-year-old orphan named Gao Jun.
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The book's central character is probably Jon, an orphan who is taunted because his absent father was not a Lamaleran.
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Her favorite person in the world is Mija (Ahn Seo-Hyun), an orphan living with her grandfather (Byun Hee-Bong).
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Maggie Mulubwa stars as Shula, an orphan who, after arriving in a Zambian village, is accused of being a witch.
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You may recall the time he said he was considering adopting an Iraqi orphan to understand the youths of today.
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The fantasy's combination of tragic pathos — a poor little orphan girl, all alone in the world, forced to sleep outside!
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Fantone's new 17-year-old daughter, an orphan from Eritrea, risked having her long-awaited journey to America slip away.
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Fantone's new 503-year-old daughter, an orphan from Eritrea, risked having her long-awaited journey to America slip away.
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At its best, Orphan Black tells stories with huge implications — whether scientific or philosophical — on the most personal of levels.
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In fact, there was a part of me that believed that Audrey knew exactly how lucky she was, but that she also knew that, as an orphan, there were all these strings she could pull to induce sympathy, love, and guilt, to buy excuses, to explain herself; and that she intended to pull those strings until they broke, which they never would, because when you were a born orphan—that is, when you'd actually spent your first few months or years in an orphanage—you got to be an orphan for life.
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That Monroe accomplished anything, coming from an orphan raising his siblings in rural Virginia, is enough of an accomplishment in itself.
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And female lead Tatiana Maslany is terrific on TV's Orphan Black but has never had a film role of this stature.
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Or did nobody think to put the famous Skywalker orphan together with the famous fallen general Skywalker from the Clone Wars?
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I am participating in VoteRunLead #RunAsYouAre2019 training for just this reason — because there is a home for orphan candidates like me.
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She had written Orphan Girl No. 58 in the early 1980s so her children could understand what she had been through.
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Most recently, Natali has been working in television, directing episodes of Orphan Black, Hannibal, American Gods, and Westworld, among other shows.
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When I was a child, I didn't give much thought to whether he — or any other adult — was really an orphan.
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Celebrities like Orphan Black's Tatiana Maslany and The Fosters' Maia Mitchell have added their voices to Spirit Day, among countless others.
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It's impossible to look back on Orphan Black without calling out Tatiana Maslany's (finally Emmy-award winning) performances throughout the series.
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But she's also a daughter, which is what "Orphan" is about — a particularly challenging time for her and her own mother.
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Spaceman of Bohemia by Jaroslav Kalfar In Kalfar's debut novel, a Czech orphan grows up to become his country's first astronaut.
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The young royals fed some orphan elephants and rhinos while spending a day highlighting conservation in the country's largest national park.
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These used to be know as "orphan drugs" because they applied to a tiny proportion of the public with rare conditions.
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And before you ask, no, mentioning the Toews/Crosby thing in a hypothetical way like that does not kill an orphan.
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She handed one to me like I was little Orphan Annie, and I thanked her for what felt like an hour.
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Angela makes contact with the three orphan ghosts who are watching the cycle of horror continue and calls on their support.
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And there s the book's heroine, a little girl named Sophie, an orphan, who becomes the BFG's great friend and advocate.
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His mother was born in South Korea, an orphan of the Korean War adopted by American parents and raised in Compton.
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She just needs to learn, like we have so many times, that when it comes to Orphan Black, never. Believe. Anything.
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If you, like me, thought last week's episode of Orphan Black was hard, then buckle up — and maybe cover your eyes.
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Once the trailer's opening sequence fades, it takes me to a surrealist floating city, home of the titular orphan girl Allumette.
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That was an increase of more than 300 from the previous quarter, according to data from Alberta's Orphan Well Association (OWA).
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Convincing families to adopt special needs children like JiaJia is a tremendously difficult task, says volunteer and former orphan Olivia Raney.
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Last week, ministry spokeswoman Tania Pereira said the government is reviewing proposals but noted orphan wells are legally a provincial responsibility.
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We are called to welcome the stranger, to love our neighbors, to seek justice, to care for the orphan and widow.
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Orphan Black is back for its fifth and final season, and we're going to try to make sense of it together.
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Many such plans have seen member companies go out of business, leaving those remaining to cover the costs of "orphan" retirees.
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The story of Natalia Grace, a Ukrainian orphan at the center of an adoption scandal in Indiana, went viral in September.
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No one knows the exact age of Natalia Grace, the Ukrainian orphan at the center of an adoption scandal in Indiana.
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And, in a manner, she was reborn there, too — as the great Parisian couturière, rather than the orphan girl from Saumur.
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In Italy's early postwar years especially, she catalyzed the desires of an orphan nation, a newborn democracy looking for a mother.
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She is also, notably, an orphan, whose flight from Iraq and resettlement in the United States Noura has helped to sponsor.
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Newton said Mosseri's argument seemed like "circular logic" — akin to saying that because Facebook is so big, it can't orphan Instagram.
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Other actors, notably Tatiana Maslany in "Orphan Black" and James Franco in "The Deuce," have won praise for playing multiple characters.
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But if the orphan drug tax credit is eliminated, the move would represent a rare defeat for the powerful pharmaceutical industry.
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Alice is an orphan unanchored by her adoptive parents, a missing theoretical physicist and the selfish, charismatic wife he left behind.
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Stephanie's life is turned upside down when she becomes an orphan after her entire family is killed in a plane crash.
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A Belgian mission to rescue and repatriate orphan children arrived in the camp in June and made Ibrahim their top priority.
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"Orphan Black" centers on a character named Sarah Manning who discovers she's one of a series of clones around the world.
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STOCKHOLM, Jan 13 (Reuters) - Rare disease drug maker Swedish Orphan Biovitrum (Sobi) has topped its 2019 sales and core profit expectations.
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Her Soviet handlers, at Gabriel's behest, are arranging for her to adopt a cute little orphan girl to assuage her loneliness.
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"This guy — mixed race, gay and orphan — he didn't start out at zero," said Massimo Piombini, the chief executive of Balmain.
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She said it was hard for her, as an orphan, to give up the protection of her weapon and her comrades.
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Heydi often complained to her aunts that everyone else had a mother and a father, but she felt like an orphan.
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The romance of the abandoned child, of the orphan on the edge of everything, can give Gibson's novels a sad sweetness.
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I mean, the orphan who doesn't know anything about his birth parents—who is he to claim that knowing is better?
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The so-called orphan drug tax credit would be repealed in the tax-reform bill that passed the House last week.
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"Orphan Black" was the rare sci-fi thriller with an emotional core, thanks in large part to its star, Tatiana Maslany.
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Originally released in 1977, the film follows Pete, a young orphan, who claims his best friend is a dragon named Elliot.
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But Orphan Black also humanizes the science of cloning by telling its origin story through the perspectives of the clones themselves.
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" (The pirates, all orphans, have a code that prohibits capturing any orphan; they are famous for this softhearted rule and he is taking advantage of it.) And then ensues a rapid dialogue of mutual misunderstanding until the major general and the pirate king sort out the difference between "often, frequently" and "orphan, a person who has lost his parents.
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Read more:A woman who claims she's the Ukrainian orphan's biological mom says the girl is a childThe Ukrainian orphan accused of being an adult hung out at a drug recovery house and took adult education classes after her adopted parents moved to CanadaA Ukrainian orphan at the center of an adoption scandal might be an adult.
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Read more: The Ukrainian orphan accused of being an adult hung out at a drug recovery house and took adult education classes during her mysterious 3-year disappearanceKristine Barnett told Daily Mail Online that Natalia is actually a mentally disturbed adult woman who terrorized her family until they moved to Canada in 2013, leaving the orphan behind.
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But while most water babies go on to pursue other professions, Victoria Orphan never wavered from her goal to become a "mirne bilogest," as she spelled it as a grade-schooler in her copy of Dr. Seuss's My Book About Me. "In general, I just feel much more at home in the water," Orphan told me.
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Steve was eight months old when his owners Amanda Whitlock and her partner Ben took in a small flock of orphan lambs.
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The BBC's Orphan Black ran for five years on television, and it's set to return later this summer on a new platform.
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When they called the agency to demand an explanation, the child's claim was confirmed: their newly adopted daughter was not an orphan.
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She is worried that the backlash will cause companies to abandon these so-called orphan drugs in search of more profitable ones.
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I basically cannot get enough of Orphan Black right now, a sort of slightly campy, very compelling sci-fi series about Toronto.
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Orphan Black — which began a new season April 14 on BBC America — has made a point of complicating its world beyond recognition.
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"It's a rare cancer, thank God, and it's considered one of these orphan diseases that don't happen very often," Dr. Marr says.
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"Kung Fu Panda 2," in 2011, ended with a surprise: The title panda, genial Po (Jack Black), wasn't an orphan, after all.
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Oil firms are eyeing opportunities in the deeper waters of the Orphan Basin and in the Flemish Pass, popularly called Iceberg Alley.
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A 63-year-old orphan girl was rescued from traffickers in India, after a co-passenger tweeted to the Ministry of Railways.
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A few years earlier, the Blossom family picked up an 8-year-old orphan Penelope from the horrific Sisters Of Quiet Mercy.
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That led to exclusivity deals, with companies paying to be the only streaming service carrying Orphan Black, or any upcoming Marvel movies.
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One drug, Keytruda, received 6 orphan approvals over the past 2 years for treating different types of skin and immune-system cancers.
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DIRCEU GRECOProfessor emeritusFederal University of Minas GeraisBelo Horizonte, Brazil If surgery is the "neglected stepchild" of global health, diagnosis is its orphan.
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In a statement, Benshetrit said he was drawn to the project because he saw the Biosphere as an "orphan" on the skyline.
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Alberta, which produces about 80 percent of Canada's crude, had more than 1,500 orphan wells last month, up from 26 in 2012.
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Drugmakers are fighting a provision that would make it more expensive to develop "orphan drugs" for serious diseases affecting relatively few people.
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Kiefer Sutherland presented this year's award to the actress, who accepted her first Emmy win and second consecutive nomination for Orphan Black.
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Approvals for new orphan drugs have more than doubled over the past decade, with a record 37 of them approved in 2015.
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The story follows a young girl named Lyra Belacqua (played by Logan's Dafne Keen) who grows up as an orphan in Oxford.
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The primary focus is to develop TAM-01 for the treatment of systemic lupus erythematosus (SLE) in an expanding orphan drug market.
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The search for answers, which often drives the action on Orphan Black, is most compelling when it bumps uncomfortably into reality. An
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"Orphan works" are those which may still protected under copyright, but for which the legitimate rights holders are unknown, and, sometimes, undiscoverable.
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This is Allumette, the orphan girl that VR film studio Penrose hopes will win audiences' hearts at this week's Tribeca Film Festival.
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The latest Transformers: The Last Knight trailer is all about Izzy (Isabela Moner), a street-smart young orphan in the Rey mold.
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Pharmaceutical companies have become increasingly interested in developing orphan drugs since they can command prices in the hundreds of thousands of dollars.
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Laufer said that Four Thieves is working to create a BioTorrent site to distribute the organic material needed to manufacture orphan medicines.
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Alberta, which produces about 80 percent of Canada's crude, had more than 1,500 orphan wells in February, up from 26 in 2012.
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But it's also an allegorical representation of his own life—the orphan-boy spewed up by the Atlantic onto an Irish beach.
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EDT to discuss how she became an orphan of sorts at age 2628 when her family was deported to Colombia. http://bit.
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"The right to keep and bear arms is apparently this Court's constitutional orphan," he complained in his dissent of the court's decision.
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Lyra (Dafne Keen) is an orphan on the cusp of adolescence living amid scholars at a college in an alternative-reality Oxford.
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True, the orphan drug tax credit could be reformed to reduce concerns over abuses, but this blunt act endangers millions of lives.
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The agency grants orphan status to medicines that treat conditions or diseases that affect fewer than 200,000 people in the United States.
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There's Sprout, who was scooped from the side of the road as a weak, dehydrated orphan and now poses in flower crowns.
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Lucious will reveal the sad story of how an orphan became one of the biggest music moguls this world has ever seen.
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This move using the antitrust division of the Justice Department, which would financially orphan CNN, is a new and more disturbing development.
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Lyra Belaqua (played by Dafne Keen) — a 12-year-old orphan who was left at Jordan College when she was a baby.
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A reminder: Dickens' other literary fixations include an orphan crime ring, the spiritual misery begat by debtors' prisons, and Christmas-based ghosts.
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Two years ago, Carol Marak, who is in her mid-60s and lives alone in Dallas, started the Elder Orphan Facebook Group.
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We'll fix up the house, put another camera or so in there, and then have more orphan kittens ready to move in.
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It is quite likely that when Bert arranged to adopt a German orphan, he had his sister in mind as the mother.
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Companies have gotten orphan designation for products that were already blockbusters, including Humira, which has long been the world's top-selling drug.
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Due to this rapid growth, multiple organizations voiced disapproval over the company's pursuit of the FDA's orphan status, citing price-gouging concerns.
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The drugmaker said it was confident of maintaining an expedited timeline for seeking regulatory review of remdesivir, without the orphan drug designation.
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Under Lila Neugebauer's direction, Tatiana Maslany ("Orphan Black"), Blair Brown and four others play Mary Page Marlowe from infancy to old age.
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During play dates, Lily often liked to play orphan, writing down long lists of chores: dichs (dishes); moping (mopping); feeding (the fish).
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He then approached her about a business he was starting called Retrophin, to sell so-called orphan drugs to treat rare conditions.
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The proportion of drugs approved with the Orphan Drug Act designation increased from 18% in 1984-1995 to 143% in 2008-2018.
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The turn-of-the-20th-century plot naturally begins with an orphan, Lily, whose mother is killed in an ah-vuh-lonzh.
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Daddy Warbucks may have been Little Orphan Annie's protector, but the composer Charles Strouse helped make her a star of the stage.
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Mr. Levi, an orphan who helped raise himself and two of his younger siblings up from poverty, was looking for a wife.
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Elizabeth Gloucester soon turned her attention to helping the Colored Orphan Asylum, taking a leading role in an elaborate fund-raising fair.
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Lenny Belardo is an orphan left by his hippie parents to be raised by nuns in an orphanage in the United States.
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Just trying to point out that whatever we fantasized about as children doesn't hold a candle to what an orphan wished for.
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The VA's motto: to care for him who shall have borne the battle, and his widow and his orphan, needs to go.
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We can afford the innovation that the great pharma companies are putting out for these rare and orphan diseases and these genetic diseases.
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"There are no subsidies, and the only supportive policy has been getting orphan drugs on the fast-track approval list," he told Reuters.
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To make yourself feel just a tiny bit better, watch the videos of rescued orphan elephants at the Sheldrick Wildlife Trust in Kenya.
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The latest designation is for the treatment of pancreatic cancer, with Lynparza having been previously granted orphan status for ovarian and other cancers.
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In the past few years, his roles have pretty much been limited to a sad orphan, Guy Fawkes co-conspirator, and grieving actor.
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A country where the daughter of an orphan can break that highest and hardest glass ceiling and become president of the United States.
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The young orphan named Nandi has a unique friendship with a cat named Mewie, according to FOX 13 News, which reported the story.
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Case in point: Harry Potter and the Baudelaire kids of A Series of Unfortunate Events are all the orphan wards of evil-caretakers.
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Eventually, Ota Benga was moved to the Howard Colored Orphan Asylum, in Brooklyn, and he ended up in Virginia, where he shot himself.
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If a drug treats an orphan disease, it can get 7 years of additional market exclusivity, free from generic competitors, for that use.
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The approval pathway has been around for 35 years, but about 23% of all orphan approvals have come in the past 2 years.
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Tatiana Maslany won the Emmy award for Outstanding Lead Actress in a Drama Series for her starring role in BBC America's Orphan Black.
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If some of Africa's orphan crops, suitably improved by genetic knowledge, were to follow suit, the benefits to African farmers would be huge.
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It follows Josué Valdés as he goes from being an orphan in the slums of Rubble City, Cuba to an accomplished galactic explorer.
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Uniqure Nv: * UNIQURE RECEIVES ORPHAN MEDICINAL PRODUCT DESIGNATION IN EUROPE FOR AMT-130 IN HUNTINGTON'S DISEASE Source text for Eikon: Further company coverage:
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At that time, the FDA granted the British drugmaker, then known as Reckitt Benckiser, a seven-year "orphan drug" monopoly on Suboxone sales.
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He leads Caltech geobiologist Victoria Orphan through a maze of wires to a cavern illuminated by the blue glow of the strontium clock.
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Murphy's wife Connie (Joanna Christie) takes the orphan girl they stole from a murder scene in Season 1 and flies back to Miami.
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Drugs that win orphan drug status are given a variety of incentives, including tax credits and eligibility for seven years of marketing exclusivity.
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Just 4-1/2 years ago, there were only 26, and the explosion in orphan wells has put added pressure on the OWA.
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Long term: The orphan drug tax credit, which gives drugmakers an incentive to research treatments for rare diseases, will be cut in half.
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The galaxy far, far away is a really big place; making her an orphan with a famous name isn't just unrealistic, it's elitist.
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Whether it's a new cancer treatment, an innovative orphan drug, or a heavily prescribed antibiotic, innovation suffers when we impose government price controls.
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She claimed, at various times, to be a Harvard medical student, a lawyer, an orphan, the founder of a newspaper and an accountant.
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Staged in front of a beautifully ugly body of water, a dying sun hanging overhead, Orphan of Kos is big, fast, and brutal.
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And Dominic Monaghan, as Reese's widowed father, vanishes so swiftly that Reese might as well have been an orphan from the get-go.
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The issue of using orphan diseases to give drugs extended protection from generic competition is playing out on a bigger stage as well.
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The National Organization for Rare Disorders calculates that eliminating the credit would result in 33 percent fewer orphan drugs developed for rare diseases.
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Mr. Trelinski is clearly moved by a theme that other directors gloss over: Tristan was an orphan and still longs for his parents.
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Delacroix's legitimate father, once France's minister of foreign affairs, died in 1805, and his mother in 1814, leaving him an orphan at sixteen.
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It now has 11 approved orphan uses in all, and exclusive protections that keep generics at bay won't run out until 2025. Sens.
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" Billy Eichner: "You ever notice Betsy DeVos and a duffel bag full of orphan bones are never seen in the same room together?
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He briefly considered becoming a rabbi and later an actor after landing the part of Punjab on the "Little Orphan Annie" radio series.
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Stores can be left with "orphan products" — a random sweater they have no way to display, because a store doesn't typically sell it.
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During debates over the tax overhaul, Center Forward worked to preserve a tax credit for researching rare-disease medicines known as orphan drugs.
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" Indeed, the report said, "Some drugs receiving orphan drug status have in fact become 'blockbuster' successes, with over $1 billion in annual sales.
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Ms. Barnett, 53, helped usher in buzzy shows like "Orphan Black" and "Killing Eve" at BBC America, which is part of AMC Networks.
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TC: Meaning… CS: The reason you hear about cancer and orphan diseases so much is that you can price high in those areas.
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Mr. Deripaska, an orphan from a small village in southern Russia, muscled his way into the aluminum business in Siberia in the 1990s.
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Being an orphan from age 6 in a very patrilineal, very patriarchal and very tribal society must have been a social death sentence.
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Nirrim is one of the imprisoned — an orphan with the ability to flawlessly forge any document and who remembers everything with perfect clarity.
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One example is the Orphan Drug Act, which was aimed at fostering research on drugs for diseases that impact fewer than 22013,22018 Americans.
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We also cover some topics that should be interesting to non-"Orphan Black" fans, like the appeal of serialized fiction versus binge-watching.
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Biogen's collaboration on Eloctate and Alproprix with Swedish Orphan Biovitrum AB will continue, CEO George Scangos said during a conference call with analysts.
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Going forward, the agency has made key changes in order to respond to all requests for orphan designations in 90 days or less.
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He'd first come to New York in 1941 as Wolfgang Grajonca, an 11-year-old Jewish immigrant, orphan and refugee from Hitler's Europe.
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So he grows up as this quintessential orphan, and only later, at the age of forty, does he start to get this revelation.
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The non-producing wells would become the responsibility of the Orphan Well Association, an arms-length operation of the Alberta Energy Regulator (AER).
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There's a love story, but what stays with you at the end of this ambitious but unruly narrative is Takis, Aliki's orphan companion.
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They said he was neither an orphan nor a migrant worker but a former forest ranger and soldier from an entirely different province.
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Magar - alert in her blue school uniform - seems worlds away from the 14-year-old orphan who came so close to dropping out.
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"I just want to talk to you all again for a moment about the wall of St. Joseph's Orphan Asylum," Father Ramsey said.
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Set in the 1930s, the story follows a lonely young orphan (Asa Butterfield) who lives in the depths of a Paris train station.
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It fostered both the beginnings of the University of Paris and, quite literally, the city's abandoned children in the orphan home it ran.
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This is a woman who's lived an unstable life since Day One, coming into the world an orphan during a literal and political shitstorm.
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And when he's dead and I'm an orphan, I know I'm going to be sorry I took this trip away from him, d'you know?
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Zheng Weiyi, chairman of Nanjing Yingnuo Pharma & Technology, said his company was among those developing 'orphan' drugs for both the Chinese and global markets.
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Alberta's Orphan Well Association (OWA) is responsible for cleaning up wells that have no owners financially able to deal with abandonment and decommissioning costs.
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BioMarin Pharmaceutical makes the so-called orphan drug and will charge $27,000 for treatment every two weeks, or $702,000 per year, executives said Thursday.
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As journalist E.J. Graff has extensively documented, the numbers cited for the orphan crisis are a significant misrepresentation of UNICEF estimates of vulnerable children.
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That could further strain the government-run, industry-funded Orphan Well Association (OWA), which cleans up wells for which no party is legally responsible.
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The connection between the Parks and the Chois would come back to haunt the President's young daughter, who left the Blue House an orphan.
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AstraZeneca, Merck – The Food and Drug Administration granted orphan status to Lynparza, a cancer drug developed in a joint venture between the two companies.
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He explores those issues in his new book What We Talk About When We Talk About Clone Club: Bioethics and Philosophy in Orphan Black.
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ANNOUNCES ORPHAN DRUG DESIGNATION FROM THE EMA FOR DCC-2618 FOR THE TREATMENT OF GASTROINTESTINAL STROMAL TUMORS Source text for Eikon: Further company coverage:
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Aladdin is called an orphan and "street rat," so it is implied that people in the town know that his parents have passed away.
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She left Vietnam when she was nine on one of last "Orphan airlift" flights out of the country before the United States evacuated Saigon.
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The story of Squall Leonhart is that of an orphan who can't quite find his place, and his social circumstances don't help much either.
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When she was just seven years old, her parents died, leaving Sarah an orphan who had to work in the cotton fields to survive.
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AstraZeneca's (AZN) cancer drug selumetinib has been granted Orphan Drug status by the FDA, a designation for safe treatments for rare diseases and disorders.
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Orphan Black, the Canadian science fiction show that revolves around human cloning, will end on Saturday, August 12th after five darkly funny, gory seasons.
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Episodes of "high-energy narratives" like "Sense8" or BBC America's "Orphan Black" were more likely to be watched in rapid succession, Netflix reported Wednesday.
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Sabrina is still a teenage orphan who had a human mother and a witch father, and who's just now aging into her magical legacy.
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How it works: Federal law gives extra market protection and tax credits to "orphan" drugs — those that treat conditions affecting fewer than 200,303 people.
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Orphan wells and related facilities are an increasing problem in Alberta, chiefly because of the slump in the oil price that started in 2014.
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The disease is so rare that the FDA considers it an "orphan disease," or one that isn't common enough to attract many drug developers.
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Mount turned to the Facebook group " 1920s antique automobile, brass era cars, orphan makes " for help in identifying his more peculiar and customized finds.
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She calls herself an "orphan of the Holocaust," having boarded the Kindertransport to Switzerland and losing communication with her parents a few years later.
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I don't know, but the fact is we don't have Monica and we don't have Thomas with us anymore and Maya is an orphan.
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The 2014 Farm Bill's expiration affected several dozen so-called orphan programs because they have authorization or funding tied to the current farm bill.
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Fortunately, Wood ended up landing the part of a German orphan in 21966's Tomorrow Is Forever, which costarred Orson Welles and Claudette Colbert.
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Canadian photographer and Vancouver Orphan Kitten Rescue Association (VOKRA) foster 'paw'rent, Tania Hennessy is creating a new way to raise awareness for shelter cats.
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Ixmyelocel-T, which has an orphan drug status in the United States, is derived from the patient's bone marrow using the company's cell therapy.
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Eugene's high school had staged "Celebration" his sophomore year, and Mr. Baxter, the drama teacher, had cast Eugene as Orphan, one of the leads.
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Orphan Black wastes no time getting to the point, and after the dramatic 5 season premiere, we're back in the thick of the action.
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It is holding what it calls an "orphan drug assessment and pricing summit" in D.C. on Wednesday to get that point across to lawmakers.
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"It's like somebody that murdered their parents and then they pled for mercy because they are an orphan," said the Senate's No. 2 Republican.
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Del Vecchio, who grew up as an orphan but is now Italy's second-richest person, said he had long dreamed of such a merger.
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"Despite the success of the Orphan Drug Act, 95 percent of rare diseases still have no treatment options," Hatch said in a statement Friday.
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Tax credits may also be dropped for orphan drug makers as well as the electricity generated by certain renewable energy sources, according to Clifton.
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Edward Church, near Fort Greene Park, was accused of sexually abusing a young orphan who slept in the rectory bedroom next to Failla's quarters.
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When she was just seven years old, her parents died, leaving her an orphan who had to work in the cotton fields to survive.
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The 2016 live-action "Pete's Dragon" follows the story of an orphan named Pete and the friendship he cements with a dragon named Elliott.
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The couple invent a lengthy story about a boxer named Sam the Russian, which is written to create a lineage for Zach, an orphan.
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The third season of "Orphan Black," the binge-worthy thriller in which Tatiana Maslany plays more than five clones (and counting), arrives on Amazon.
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The tramp is here a father figure, looking after an orphan played, in a star-making turn, by the 6-year-old Jackie Coogan.
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Kaiser Health News reports that pharmaceutical companies are taking advantage of the Orphan Drug Act — a law aimed at rare diseases — to maximize profits.
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Katie Orphan: There are a lot of factors that go into a book's rarity, and there are a few different ways that it happens.
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The Ukrainian orphan at the center of an adoption scandal in Indiana is breaking her silence this week in an interview with Dr. Phil.
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The first book she wrote, "The Search for Delicious," about an orphan boy surveying the tastiest food in the kingdom, was published in 1969.
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In the town of Boda, in a junior high school with 700 students and two functioning classrooms, we met an orphan named Lionelle Ngombe.
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Ms. Altman, 210, agreed to talk about her mother but knew almost nothing about the orphan photographed with her mother on the LaGuardia tarmac.
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The Netflix show features Finn Jones as Danny Rand, an orphan trained in martial arts who returns home to fight for his family's legacy.
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"The reason you hear about cancer and orphan diseases so much is that you can price high in those areas," the Venrock partner explains.
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And while I was certainly not an orphan, I recognized that, unlike most people in my country, I wouldn't live with my parents long.
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That he put two of his fingers together and promised that he and the orphan would be that close in the life to come.
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She chronicled her love of conservative leaders over the years and her start in the U.S. as an orphan and immigrant from South Korea.
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Feeding the hungry, sheltering the refugee, caring for the sick, comforting the grieving, parenting the orphan — all of these ministries are crucial church activities.
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A grifter called Gentleman persuades Sue Trinder, an orphan living and working among petty thieves, to become a maid to the heiress Maud Lilly.
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Bardot plays Juliette, an 18-year-old orphan who works in a bookstore and scandalizes her hardworking foster mother with her willful, wanton ways.
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She ran boardinghouses whose lodgers included members of New York's elite, raised money for an orphan asylum and was active in the abolitionists' cause.
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This adaptation of Lucy Maud Montgomery's 1908 classic is followed at 9:173 in some markets by "Pollyanna" (2005), about yet another plucky orphan.
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The titular Gideon is an 18-year-old orphan, a foundling who grew up in the bone-obsessed necromantic cult of the Ninth House.
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The removal of a tax credit for companies to conduct research into treatments for orphan diseases will discourage companies to invest in new drugs.
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In the first novel of his trilogy, "Blood in the Sun," Farrah writes about a young man, an orphan, obsessed with his own origins.
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The best actress drama category is wide open since last year's winner — Tatiana Maslany — is ineligible because "Orphan Black" debuted too late this year.
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"Her son was not an orphan body for everyone to look upon," Claudia Rankine wrote in June 2015 for The New York Times Magazine.
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Todd: BTW, that orphan Martha might adopt is the most adorable child ever, which overrode my initial, "Oh, come on!" objections to the story.
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The sight of bats bursting forth from caves at dusk is majestic enough to dazzle any spectator, scientist, or Gotham City billionaire orphan vigilante.
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After years in hiding, Susan Duncan is coming out of the woodwork on Orphan Black, and she's ready to take one clone back with her.
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In the comics, White Wolf is a white man who was left an orphan when his parents died in a plane crash inside Wakanda's borders.
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Another genius pointed out that this was exactly how the show Orphan Black started, prompting another viral tweet and a response from the show itself.
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Guests included Prime Minister Justin Trudeau, Orphan Black actress Tatiana Maslany, Howie Mandel, Nathan Fillion as well as musical performers French Montana and Erin Bowman.
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That's why it's so promising that the fourth season premiere takes a deep breath and a significant step back from Orphan Black's preexisting, overlapping stories.
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Maslany's deft performance of any given handful of clone characters is Orphan Black's one constant, and that still holds true for this fourth-season premiere.
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With the end of Orphan Black imminent, we're looking at the real world for our fix of real science straddling the world of science fiction.
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It's nothing at the level of Maslany's work on Orphan Black, but it's a supreme example of an actor elevating the material she's been given.
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Epidiolex was given orphan status from the U.S. Food and Drug Administration for the treatment of Lennox-Gastaut in 2014 and Dravet syndrome in 2013.
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Still, a few humans remain on the side of the Autobots, including scrappy teen orphan Izabella (Isabela Moner) and failed inventor Cade Yeager (Mark Wahlberg).
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Watch It If You Like: Shows that define genre classification, badass women leads, and reluctant superheroes, like the The Incredible Jessica Jones and Orphan Black.
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The housewife, DJ, rebel fighter, and orphan are led by army officer Chike Ameobi, who defected from the army after being ordered to kill civilians.
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At just 19, Mary was a widow, an orphan, and a queen determined to create a modern kingdom, where Catholics and Protestants could coexist peacefully.
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One way to reduce stunting would be to improve the crops that Africans, particularly those in the countryside, actually eat—in other words, orphan crops.
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And there's a little part of you that wishes you could go down there and take all the little orphan ones and look after them.
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The US Food and Drug Administration has given the drug "orphan status", which allows firms to get tax credits and other incentives to test it.
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Anyone who's ever called their own adopted pup "a little piggy" can understand how simple it is to care for and nurture a needy orphan.
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Molly has also been made an orphan being raised by the Pride members the Yorkes, and thus a foster sister to her fellow Runaway Gert.
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