When only one parent carries a heterozygous mutation on a gene, about half of the embryos from that parent should be mutation-free while the others would have the mutation.
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In science, a founder's mutation refers to a genetic, evolutionary mutation that essentially creates a new population.
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As a result, RNA viruses have a mutation rate up to 100 times higher than mutation rate for DNA viruses.
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She had a KRAS mutation and her TILs included killer T-cells that locked onto the mutation like guided missiles.
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The deadly diagnosis is due to an inherited gene mutation, although it can be caused by a random gene mutation, too.
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Some mathematics might put the choices into perspective: If a woman carrying the BRCA-21 mutation conceives a child with a man carrying no mutation, then the chance of having a child with the mutation is one in two.
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Huntington's disease, a classic example, is caused by a single gene mutation: If you have the mutation, you will develop the disease.
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Dr. Whiteman and his colleagues suspect that the 122 mutation is beneficial to insects only if it is preceded by another mutation.
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Whether it will be Ms. Cameron's mutation or another individual's mutation that directs the future of painkillers, it's too early to say.
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"We might find that everyone with a disease has this particular mutation but not everyone with that mutation gets the disease," Beggs said.
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Some evidence suggests the S139 mutation makes Zika virus more infectious, which might help explain why the mutation survived in its viral genome.
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She told me that she carried a mutation in the BRCA-1 gene—a mutation that she had likely inherited from her father.
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Sometimes, by chance, one of those marrow stem cells acquires a mutation, and the white blood cells it produces carry the same mutation.
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Out of 54 embryos, 36 emerged mutation-free, a significant improvement over natural circumstances in which about half would not have the mutation.
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The link between the gene mutation and the disease may not be absolute or predictable, yet the presence of the mutation increases risk substantially.
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For example, a mutation in a certain tomato gene makes the fruit particularly easy to grow, so researchers forced the same mutation in groundcherries.
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The drug, ataluren, is designed to treat Duchenne muscular dystrophy (DMD) caused by a mutation in the DMD gene known as a nonsense mutation.
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The gene-editing tool has also been used to correct a disease-causing gene mutation in human embryos, preventing the mutation from passing to future generations.
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In April the New York Times reported that its test for the BRCA1/BRCA2 gene mutation for breast and ovarian cancer missed 90% of the mutation carriers.
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Sometimes, a drug that works against a mutation in one type of cancer also works against that same mutation in another cancer, but sometimes it does not.
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They believe that even if cells can't direct the precise mutation needed in a certain environment, they can adapt by elevating their mutation rate to promote genetic change.
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It showed that half the patients treated with the combination survived advanced melanoma with a common gene mutation called a BRAF mutation nearly three years after the treatment.
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Translarna is designed for patients who have DMD caused by a specific mutation known as a nonsense mutation (nmDMD), which also accounts for 13 percent of DMD cases.
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But in smaller populations with less diversity, the chance that a rare mutation like this already exists is slim: Evolution is put on hold until that mutation develops.
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However, we still don't know what the probability is of a single smoking-related DNA mutation turning into cancer, or which mutation types are likely to be more malignant.
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While carrying a genetic mutation won't make someone sick, if their partner carries a risk factor or mutation for the same disease, their kid could be born affected with it.
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They argue that even if higher mutation rates yield adaptations to environmental stress, proving that the higher mutation rates are themselves an adaptation to stress remains difficult to demonstrate convincingly.
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"M" signifies individuals with the mutation; black circles represent individuals with MS and age of disease onset; gray circles or squares denote individuals with the mutation whose health is unknown.
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Ideally Lay would love to stabilize the flower's mutation, but it's unclear whether or not the she can actually claim ownership over the flower's mutation even if stabilization is possible.
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If someone with the FAAH mutation, however, does use cannabis regularly, they're less likely to experience emotional withdrawal when they stop using it than do other people without the mutation.
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If there's a mutation in a DNA repair gene, like a BRCA mutation, then those cells may be more responsive to drugs like PARP inhibitors that block that PARP enzyme.
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At one level, that sounds a little selfish, until you realize that her type of mutation, a 'nonsense' mutation ... is responsible for disease in many other genetically inherited forms of disease.
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And today its plot thickens: In a study published in Nature, researchers have pinpointed the precise genetic mutation that led to the darker moth and determined just when this mutation occurred.
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But the chance of having a mutation of unknown significance — 20133 percent — was the same as the 4.5 percent chance of having a known and risky mutation in the BRCA2 gene.
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Evolution is driven by random mutation — mistakes, not plans.
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" "I might have some mutation, or something like that.
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This slow mutation rate has two implications — both positive.
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Even if a mutation might not be beneficial for people who are healthy, in people who are infected with HIV, "there's clearly a positive effect" when a mutation is introduced, said Nielsen.
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It allows scientists to break DNA at sites where there might be a mutation, and allow cells to repair that mutation by introducing new genetic information, Doudna explained to CNBC in 2014.
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When a known cancer mutation cannot be matched to an approved treatment, results from the test using NGS can help determine a patient's candidacy for clinical trials linked to their specific mutation.
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Symdeko was approved for CF patients aged 12 and older who have two copies of the F508del gene mutation or who have at least one mutation that is responsive to tezacaftor/ivacaftor.
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But soon after, other researchers demonstrated that as an infertility mutation in female mosquitoes was successfully passed on to offspring over many generations, resistance emerged, allowing some mosquitoes to avoid inheriting the mutation.
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According to the National Cancer Institute, 55% to 65% of women who inherit a BRCA1 mutation and around 45% of women who inherit a BRCA103 mutation will develop breast cancer by age 70.
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Knowing that a person carries a BRCA mutation also provides an opportunity to test and identify relatives who may carry a harmful mutation — potentially preventing and detecting cancer early in a whole family.
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Screen for the most common mutation, then try that drug.
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Not every lung cancer patient will have that same mutation.
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It found that 15 of those carried the CHD8 mutation.
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"How are you going to exploit Kira's mutation?" she asks.
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Still, "Founder's Mutation" gives me faith in this new iteration.
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Turns out, 1 in 40 Ashkenazi Jews carry this mutation.
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Bet on CRISPR succeeding first against a rare, single mutation.
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The team found six Turkish families affected by the mutation.
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The mutation trashed the brakes, locking the cells in overdrive.
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This is the first to correct an inherited genetic mutation.
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Hence, the FAAH mutation causes people to have more anandamide.
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Researchers had already found this mutation in dogs and cattle.
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A mutation, to be detectable, had to be very common.
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In places where malaria was prevalent, the mutation offered protection.
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The mark doesn't directly damage the gene; there's no mutation.
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The new case had that mutation, plus three additional ones.
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Otherwise, the brutal Shabab or its mutation will remain entrenched.
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The third mutation arose in an even more recent ancestor.
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And there the mutation could have theoretically caused Astrea's problems.
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The pink splotches, called variegation, come from a genetic mutation.
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It treats a mutation affecting about 13 percent of sufferers.
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These biological events can promote cell mutation and tumor progression.
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They found that people who carry two copies of the mutation are more than 20% less likely to reach age 76 compared to people who have either one or no copies of the mutation.
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In principle, if the BRCA-1 mutation could be altered in egg cells or in sperm cells bearing that genetic mutation, the gene would be "fixed" (or restored to its non-mutant form) forever.
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Sometimes targeting a mutation fails because it is only one of many driving the tumor, or because the mutation occurred at random in the genetic chaos, a passenger, while other mutations do the driving.
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The Christchurch mutation is extremely rare, but several years ago, Dr. Reiman's daughter Rebecca, a technologist, helped determine that a handful of Colombian family members have that mutation on one of their APOE genes.
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In the early nineties, research on C. elegans , a tiny nematode worm that resembles a fleck of lint, showed that a single gene mutation extended its life, and that another mutation blocked that extension.
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I have a theory that there is a genetic mutation—well, not a mutation perse, but definitely a quirk—that affects around one in eight people and completely robs them of the ability to whisper.
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Demetriou also pointed out that this mutation isn't 100 percent predictive, nor does it apply to the vast majority of MS cases (this mutation is found in only one out of every 1,000 MS patients).
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The women in my family carry the BRCA2 gene mutation, which increases one's risk of developing breast cancer to 85%, and a couple years ago, I discovered that I have inherited the mutation as well.
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In this case, the researchers observed one mutation of zebrafish that was more susceptible to TB, so they started investigating what kind of mutation it had and why it might be causing this increased susceptibility.
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The results released Tuesday are from studies aiming to expand treatment options to 90 percent of people with cystic fibrosis, those with one copy of a mutation known as F508del, and one minimal function mutation.
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The scientists noticed each had a mutation in the SELENBP1 gene.
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Only the rare nugget in the mine is a beneficial mutation.
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These include things like fast generation times, high mutation rates, etc.
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Doctors think Henry's exact genetic mutation is one of a kind.
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The mutation suggested he had a disease called Coffin-Siris syndrome.
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"That's probably because they have a higher mutation rate," VandeWoude said.
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About one in fifty people with high cholesterol have the mutation.
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This wasn't a cancer diagnosis; it was just a genetic mutation.
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Most diseases are far more than just a simple gene mutation.
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You can have psychosis without a RBM12 mutation, which is crucial.
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Some have hypothesized that cancer tumors are a mutation of viruses.
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Mutation carriers were also more likely to have their ovaries removed.
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However, this is the first to correct an inherited genetic mutation.
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So which is the driver mutation and which are the passengers?
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Albino animals, in contrast, carry a mutation that inhibits melanin expression.
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Different ethnicities are more prone to this gene mutation than others.
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"One copy of the mutation, you're a bit hungrier," Raffan says.
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But research shed light on a new mutation in her body.
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This was the initial step toward the revolution in enzyme mutation.
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If they had, she could have learned of the mutation earlier.
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Some patients are told they have a mutation that is meaningless.
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His children and direct relatives must be tested for the mutation.
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The researchers scanned the DNA surrounding the mutation in those people.
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Eventually Dr. Might found about 60 other people with this mutation.
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The mutation makes the molecule warp into a rigid sickle shape.
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It is caused by a mutation in a gene called MYBPC3.
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The mutation is helping scientists understand how our bodies regulate sleep.
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Their third child, Ryan, did not inherit the sickle cell mutation.
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But where, exactly, in this distorted format, is the implied mutation?
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In 2015, researchers demonstrated this, reporting that as an infertility mutation in female mosquitoes was successfully passed on to all their offspring over many generations, resistance also emerged, allowing some mosquitoes to avoid inheriting the mutation.
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He discovered that this unintended consequence was the result of traditional breeding: When breeders favored the jointless mutation, they unwittingly produced unwanted branching as well because of a complex interaction between jointless and another ancient mutation.
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Ms. Ryan's case made medical history, because it was the first time researchers found cells that could attack a common cancer causing mutation — a finding that may help thousands of other patients with the same mutation.
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But these results are arguably more distressing than the eye-mouth mutation.
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This led to the identification of a mutation in its tnnt2 gene.
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The study involved 50 participants with ALS caused by the SOD1 mutation.
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And sometimes the difference comes down to a single gene or mutation.
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That type of mutation is extremely unlikely for something like, say, malaria.
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He remains in power, but his mental mutation has been subtly neutered.
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A comparison of two fea3 mutation corn ears with other "normal" ears.
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It meant I could have treatment targeted at my particular genetic mutation.
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No single genetic mutation raises a person's risk of diabetes by much.
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Marsili feels no pain thanks to a mutation in her ZFHX2 gene.
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This genetic mutation confers resistance to hypoxia, otherwise known as altitude sickness.
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He was born with a genetic mutation called mitochondrial DNA depletion syndrome.
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Some researchers are looking into fixing the mutation itself through gene therapy.
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They are identifying rare individuals in families with a disease-causing mutation.
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There are 212.5,210 base pairs in the BRCA 250 mutation, noted Brawley.
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Mutation produces variety and deviation; selection kills off the least functional mutations.
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The mutation appears to be specific to people of Ashkenazi Jewish descent.
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The libertarian movement has seen a nasty mutation in the Trump years.
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The mutation actually made the viruses worse at infecting the bat cells.
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He ultimately gave mice a mutation that gave them huge, ripped muscles.
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The effects of mutation in real life are nuanced and generally innocuous.
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I suspect that my genetic mutation also came from my paternal lineage.
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That mutation increases the risk of a disease, or it does not.
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How widespread among fungi and other life is this low mutation rate?
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Still, the association between the genetic mutation and athletic performance is interesting.
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Is it a mutant or a mutation that we are looking at?
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The disorder was caused by a mutation in a gene called FOXC2.
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But a single mutation created it, and the creature can clone itself.
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The mutation means it&aposs unable to carry oxygen throughout the body.
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About 75 percent were the killer T-cells that targeted her mutation.
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The activity-director mutation runs strong among the women in my family.
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Some of her cells carried the deadly mutation, but others did not.
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After one cell mutates, scientists found, all its descendants inherit that mutation.
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Next they bred mice with the mutation and examined their sleep patterns.
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The mutation is rare; only one in 4 million people has it.
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The genetic mutation increases one's chances of developing certain types of cancer.
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This could include mutation to produce an oncogene that can cause cancer.
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I was first tested and learned of my mutation in the 1990s.
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He concluded, as a result of all this, that there might be one potential off-target mutation, that no mutation existed in the 609 cancer-associated genes he tested and that no large chunks of DNA were missing.
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Accordingly, if a mutation — beneficial or harmful — is passed down to different offspring, conventional genetics show that it's possible for wolf offspring to acquire two copies of a recessive genetic mutation, which would then manifest as a physical change.
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Still, figuring out how the mutation worked was enough to give the researchers an idea: perhaps a more muted version of the mutation could give them more kernels of corn but not so many that it killed the ear.
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By expanding out to look at the two bases either side of the mutation—ACA changed to AAA, ACC to AAC, ACG to AAG and so on—Stratton and his team ended up with 225 different subtypes of mutation.
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Among a total of 237 women tested during the study period, 21996 did have what's known as a BRCA220 mutation and 240 reported having a BRCA220 mutation, while another 21 women said they had an indeterminate result or variant.
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Their results suggested that while 83% of thyroid-cancer patients in a control group had this mutation, only 53% of thyroid-cancer patients who'd lived in at-risk locations at the time of the nuclear accident had the mutation.
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Once they learned, from his spit test, that he has a rare genetic mutation that increases the risk for Parkinson's disease, she bought the patent on a gene variant that could protect people who have that Parkinson's-related mutation.
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By expanding out to look at the two bases either side of the mutation -- ACA changed to AAA, ACC to AAC, ACG to AAG and so on -- Stratton and his team ended up with 96 different subtypes of mutation.
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And she discovered that she has a BRCA2 mutation, a gene called BRCA2.
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The severity of the odor depends on how severe the gene mutation is.
|
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Genetic errors like a mutation that would cause a disease in an infant.
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The syndrome has a genetic component, a mutation on a gene called ZFHX2.
|
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The Novartis treatment is designed for selected patients with a particular genetic mutation.
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Instead, the animal likely has a genetic mutation that affects only fur pigmentation.
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Between 5-10 percent of patients with breast cancer have a BRCA mutation.
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Researchers looked at the virus genetics and mutation rates to determine the figure.
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We are now beginning to hack away at the second pillar, random mutation.
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This mutation was absent from other breeds (except the related flat-coat retreiver).
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Using CRISPR-Cas9 alone for such point-mutation work is only 4% effective.
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"We're not saying we have found the mutation that controls sociability," vonHoldt says.
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It could be a mutation of an already known disease, such as influenza.
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If you think mutation is a dirty word, you should probably stop reading.
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That said, the CCR5 mutation does not protect individuals from all HIV strains.
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If a mutation is destroying your cells, we could simply splice it out.
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People who inherit this mutation from both of their parents are naturally immune.
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Patke is herself a night owl and tested herself for the genetic mutation.
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The eggs used to produce the zygotes did not carry that gene mutation.
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The lice are able to resist these chemicals thanks to a genetic mutation.
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Unfortunately, that same mutation has also been shown in houseflies and (eeeeep) bedbugs.
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"And their family members may be affected with the same mutation," said Schlager.
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Alongside the tablets, the agency also approved a diagnostic to detect the mutation.
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We force at least a certain amount of mutation, even when systems resist.
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But his team found that the mutation was relatively common in Ashkenazi Jews.
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It is not clear what role the mutation played in West Africa's epidemic.
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The people with this mutation seemed to live ten years longer, on average.
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The mutation causes melanin, a dark pigment, to express itself as black fur.
|
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It's most common among Yoruban Nigerians, among whom 45 percent have the mutation.
|
|
The plot centers around a doctor who shares a similar mutation as McCoy.
|
|
The culprit turned out to be a shared mutation in the ADGRE2 gene.
|
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This vaccine mutation resulted from an egg-based manufacturing process commonly used today.
|
|
And the discovery enabled doctors to find other patients who carry this mutation.
|
|
The two works on wood, both from 2018, are preludes to Belag's mutation.
|
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They conclude that the mutation arose roughly 7,300 years ago in West Africa.
|
|
Organisms pass on their characteristics to their offspring, but with random variation (mutation).
|
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Only eight of these patients had gotten a test that revealed the mutation.
|
|
This provides a potent biologic mixing bowl and natural influenza virus mutation factory.
|
|
Nonetheless, patients responding to immunotherapy were the ones with the master gene mutation.
|
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And its genome harbors a mysterious survival strategy: an extremely low mutation rate.
|
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Another concern: Sometimes cells spontaneously acquire a mutation that disables the p53 gene.
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Studies in the mid-2000s suggested that this mutation might make children short.
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They had expected that long-lived men with the mutation would be short.
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Downing turned to the internet to find others with the same gene mutation.
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Another 13 embryos also emerged without the mutation, but not in every cell.
|
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It turned out a mutation had moved that chunk over to chromosome 9.
|
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But when Dr. Priest ran a different test, he couldn't find the mutation.
|
|
People with the mutation appear to be doing that cleaning much more efficiently.
|
|
People with the mutation can be repeatedly exposed to H.I.V. without getting infected.
|
|
The treatment, golodirsen, targets a genetic mutation affecting about 8 percent of patients.
|
|
Meanwhile, humans have a gene mutation that prevents us from doing the same.
|
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She suspects this may be because she inherited the mutation from her father.
|
|
But though having this mutation may sound like a dream, there are downsides.
|
|
The leaf green of a quetzal's tail, the cerulean blue of a tree swallow's back, the golden-eyed wings of a great argus are the work of an infinitely patient genetic process—mutation upon mutation, like paint layered on canvas.
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People with two copies of a mutation that protects against the HIV virus, known as CCR5-delta 32, are more likely to die before age 76 than individuals without the mutation, according to new research published today in Nature Medicine.
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When Quinn got his diagnosis, they started to research his mutation, and the family is now fundraising to hire a postdoc at The Laboratory of Cellular Neurobiology at Massachusetts General Hospital to study the mutation full time for a year.
|
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Dr. Vaughan and his colleagues, including Dr. Amy Shapiro, a hematologist who first discovered the mutation, are hoping to do more studies with the Amish to see how the PAI-1 mutation affects cognitive function and other aspects of health.
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The mutation is linked to a number of disorders — women with the mutation may have a higher risk of having babies with defects like spina bifida — and Ms. Evans wanted to make life changes for her children based on the results.
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They needed to develop a genetic mutation to even process the lactose sugars properly.
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But one of the oddest evolutions has been the mutation of the conspiracy theory.
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So when researchers find a gene mutation or variant, it is easier to trace.
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Then she selected the best for a further round of random mutation and screening.
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The more this mutation was able to suppress SMOC2, the flatter the dogs' faces.
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Coronaviruses, on the whole, are "somewhat less prone to mutation than flu," Morse said.
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It can target genes in a specific location -- for instance, to disrupt a mutation.
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The mutation made the crayfish able to clone themselves — and reproduce only female offspring.
|
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But sometimes a woman may be born with a mutation in her mitochondrial DNA.
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So some of that she does just through kind of random mutation and selection.
|
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But whether it amplifies or dampens pain depends on the mutation an individual carries.
|
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The drug secured approval for relapsed or refractory AML patients with an IDH210 mutation.
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Scenario 2: mutation is neutral and mutants continue to breed with us regular humans.
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A mutation in an RNA virus could also make it milder and less deadly.
|
|
But Mitalipov was able to avoid mosaicism, ensuring that all cells were mutation-free.
|
|
As it bloomed, she noticed a beautiful variegated mutation in one of her flowers.
|
|
But sometimes the process goes haywire, particularly in the event of a genetic mutation.
|
|
When we know a cancer's mutation, he said, it's sometimes possible to customize treatment.
|
|
My breakthrough moment came when it was discovered that I had the ALK+ mutation.
|
|
The mutation became more common in populations as it conferred protection from the disease.
|
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A mutation might get permanently lost in the crowd unless its advantage is great.
|
|
But the mutation couldn't be spotted in any other dog, short-faced or not.
|
|
Bub's mutation, it turns out, causes one of the least severe forms of osteopetrosis.
|
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Why it matters: Huntington's disease is an inherited condition resulting from a genetic mutation.
|
|
Doctors can pick a drug according to the specific DNA mutation driving cancer forward.
|
|
The plan now: develop drug candidates to mimic the protective effects of this mutation.
|
|
This isn't the first time people have tried to fix the sickle gene mutation.
|
|
Obama certainly had good reasons for attacking ISIS as a cancerous mutation of Islam.
|
|
Dr Fahrenkrug has also been working on a famous mutation that increases muscle mass.
|
|
Franklin Graham is the most dramatic evidence of the mutation Graham helped to engineer.
|
|
The tree showed that one mutation arose at a crucial point in the outbreak.
|
|
Or you'd need hundreds of people with a rare mutation who aren't terribly sick.
|
|
Our evolution and survival to date have been based upon random mutation and competition.
|
|
The cancer is associated with a genetic mutation that's also common in healthy patients.
|
|
Some cases are more severe than others, depending on which genetic mutation they carry.
|
|
Just one mutation can influence how much a dog scavenges for food, for instance.
|
|
Dogs across the board are growing fatter, whether or not they have a mutation.
|
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As a result, a mutation seen as benign today may be found dangerous tomorrow.
|
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And to give all those affected by this mutation a village of their own.
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Even when drugs are a good match for a mutation, they don't always work.
|
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The child survived, had a family and passed down the mutation to future generations.
|
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Later, the study suggests, Africans carried the mutation to other parts of the world.
|
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In 2001, scientists reported that all these effects resulted from a single gene mutation.
|
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The process isn't perfect, and the repair may be faulty, resulting in a mutation.
|
|
Then the team made seven strains of the Zika virus, each with one mutation.
|
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In mouse embryos, the S139N mutation caused more severe microcephaly and dead brain cells.
|
|
The researchers also did not try to address why this mutation might have persisted.
|
|
People with this mutation can make working receptors, but their shape is slightly different.
|
|
Consider a mutation that has good effects early in life and bad effects late.
|
|
The message said the problem might be a mutation on a gene called FOXG1.
|
|
Astrea's SCN5A mutation must have originated in a cell that existed before that stage.
|
|
Of the 23 young people who had inherited the mutation, 18 had died suddenly.
|
|
"The mutation of the virus still needs to be closely monitored," the statement said.
|
|
Women with this mutation have a higher risk of developing blood clots during pregnancy.
|
|
They found a new doctor, this time one who specialized in Patricia's clotting mutation.
|
|
I was diagnosed with Parkinson's disease with the rare GBA mutation at age 49.
|
|
The treatment targets a genetic mutation affecting about 8 percent of patients with DMD.
|
|
A mutation on the gene PDSS2, for example, is associated with drinking less coffee.
|
|
In January the FDA granted the company's request to alter the drug's proposed patient population to include any person with an inherited retinal disease due to a biallelic RPE65 mutation, meaning that the mutation is found in both copies of the gene.
|
|
In late 2015, researchers reported that while a CRISPR gene drive had indeed allowed an infertility mutation in female mosquitoes to be passed on to all offspring, as the mutation increased in frequency over several generations, resistance to the gene drive also emerged.
|
|
The researchers noted that strains of the virus without the S139N mutation caused some mice to develop mild microcephaly, meaning that the mutation, which occurs on a protein involved in making the virus's protective coating, is likely only a piece of the puzzle.
|
|
It's consistent with the benefit of the higher mutation rate—the additional capacity for exploration.
|
|
Nobody knows what makes a single genetic mutation morph into all the symptoms Grace experiences.
|
|
Overall, about 35 percent of patients had an elevated risk of carrying a genetic mutation.
|
|
And nobody understands why some people with the mutation develop Alzheimer's and others do not.
|
|
Such diseases are usually caused by a single genetic mutation and first strike in childhood.
|
|
After learning I carried the BRCA 2 genetic mutation, I immediately chose to take action.
|
|
This mutation process may even vary in different parts of the world, for various reasons.
|
|
Though Mystique's mutation allows her to transmogrify into other humans, her natural form is blue.
|
|
Two of the ten, they found, had no relevant mutation, and presumably retained trichromatic vision.
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The emergence of fake events as the new fake news represents a significant new mutation.
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We can sequence your cancer's mutation, but that doesn't explain why you have brain cancer.
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The mutation, for example, makes people four times more likely to die from the flu.
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Most people who have a genetic mutation that predisposes them to cancer don't know it.
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It's a recessive mutation in a gene called TAF1A that Linsey and Noel both carry.
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It turned out something else was odd about the curly mutation: It was temperature sensitive.
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Krystian, a sanguinarian from the UK, was diagnosed with a genetic mutation two years ago.
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Jolie said she made her decision because she has a mutation in her BRCA1 gene.
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Role of genetics: One way genomes evolve is via random mutation (also called neutral evolution).
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For men, at least 360 of the carriers of the mutation will develop prostate cancer.
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"Each film introduces a type of mutation which is brought forth by technology," Wu continues.
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Now there was mutation and selection—through a combination of individual ingenuity and group preference.
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It is to be used along with a companion diagnostic designed to detect the mutation.
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The GPA82V mutation alters the gene that directs production of Ebola's surface proteins, called glycoproteins.
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They also found the mutation in early Icelandic horses from the 9th to 11th centuries.
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Plus, while this mutation worked well, editing other genes might kill the wasps (or worse).
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The doctors thought that maybe he had a mutation to where he didn't feel pain.
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There were only a few families in the world with that specific mutation, he says.
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His version of dance music is one that's not based only on pleasure, but mutation.
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And dogs with multiple copies of the mutation were even more likely to be fat.
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The boy's DNA revealed a mutation in a protein that transports vitamin B12 into cells.
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For example, one healthy baby had a genetic mutation associated with narrowing of the aorta.
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But the haplotypes also gave scientists a chance to explore the history of the mutation.
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A single drastic mutation in a single crayfish produced the marbled crayfish in an instant.
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This super-proliferation, often caused by a single identifiable mutation, is what usually indicates cancer.
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Patients with the mutation appeared to develop only plaques and tangles, and no other pathologies.
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That happens even in people with the genetic mutation that leads Alzheimer's in middle age.
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But some people carry a rare mutation in MC4R that prevents the gene from working.
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Most people with the H.I.V.-resistant mutation, called delta 32, are of Northern European descent.
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With the gene more active, patients with the mutation may be better protected against cancer.
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The mutation is not just inherited; the Pten gene is spontaneously mutated in many tumors.
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Unfortunately, the disease can resurge during fall 2020, possibly after a mutation, causing another wave.
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A drastic mutation in a single crayfish gave the creature the ability to clone itself.
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Another 5 percent to 10 percent of cases are hereditary, caused by a genetic mutation.
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The mutation, they found, was present in 12 percent of the men over age 100.
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Exactly how this particular breed came to carry the mutation is somewhat of a mystery.
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He concluded that she had a mutation in one copy of a gene called SCN5A.
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Variegated plants, like the pink princess, get their differently colored streaks from a genetic mutation.
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So if a man has a BRCA2 gene mutation, then that elevates the risk from .
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What if you carried a genetic mutation that left you nearly impervious to heart disease?
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A potentially more aggressive, inherited form, driven by a mutation in a gene called GBA.
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Then came zapping chestnuts with gamma radiation, in the hopes of producing a beneficial mutation.
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But drug development is hard, and vaccines can be particularly tricky due to viral mutation.
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In all, 36 out of 54 embryos ended up with mutation-free copies of MYBPC3.
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The osteoporosis drug Romosozumab was discovered by investigating a genetic mutation in South African Afrikaner patients, and Alirocumab, a cholesterol drug, was discovered by researchers at the University of Texas at Austin, who identified a genetic mutation in an African population, says Ene-Obong.
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If someone ends up being a carrier of a mutation that can lead to a higher risk of cancer, that mutation came from somewhere in the family tree, and identifying who else possesses it can also help them potentially intervene before things get worse.
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One doctor thought there must've been an underlying genetic mutation causing all of this wayward development.
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Amgen's result "reflect a higher likelihood of a positive readout" for Mirati's KRAS mutation-blocking drug.
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The line that evolved the ability to use citrate did not have an elevated mutation rate.
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And there's no single genetic mutation that will ever explain why someone is prone to depression.
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Testing positive for a BRCA1 mutation at age 26 also played a role in this decision.
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It is not quite random, as most people who develop it carry a single genetic mutation.
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Klute had a family history of breast cancer and a genetic test revealed a BRCA1 mutation.
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The gene mutation also meant that Boesen was at a high risk of getting ovarian cancer.
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It was a random mutation, so she felt relief her second child was at little risk.
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A single mutation might have been enough to switch a molecule from one job to another.
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Children with the Grays' particular mutation of Batten die between the ages of 6 and 12.
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O developed a novel drug for a wide variety of tumors that share a rare mutation.
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These tools accurately assess the likelihood of carrying a harmful mutation in one of these genes.
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The test was for a mutation of the BRCA gene, which helps stop cancer from developing.
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As in Mr Brown's case, the cell donor had inherited the protective mutation from both parents.
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Scientists have already isolated the MSTN/IVS1+5G>A mutation, which increases muscle mass and strength.
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It turns out, there are a few benefits to the mutation that science only discovered recently.
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Certain cells, for reasons that are still to be determined, are simply more susceptible to mutation.
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It could be that some cells replicate with greater frequency, yielding more opportunities for a mutation.
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Only women who carry a BRCA gene mutation are considered at high risk for ovarian cancer.
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However, the mutation was found to occur in about three out of every four assistance dogs.
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Every 8 months, men produce a new genetic mutation that gets passed on to their children.
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Of four others, carrying a mutation that causes thalassaemia, another anaemia, only one was successfully edited.
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Her Dravet Syndrome—which causes severe seizures—is caused by a single T to G mutation.
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And seven, or 153%, carried a different mutation on BRCA215 or BRCA230 than what's widely known.
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I have that gene mutation too, and it's not something I would believe in for myself.
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After the ad went out, two female snails with the same genetic mutation were quickly found.
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Scientists are able to correct a gene mutation in human embryos linked to inherited genetic diseases.
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Retinal dystrophy due to mutation of the RPE20073 gene causes severe visual impairment beginning in infancy.
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And it is the amount of mutation this peripheral DNA has undergone which is the giveaway.
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It's unclear what the growth is exactly, but it's probably a mutation that occurred at birth.
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But later infections, without the initial priming, can trigger leukemia in those with the genetic mutation.
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Herceptin, for example, dramatically altered the outcome of breast cancer in patients with the HER2000 mutation.
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What we want and don't have, however, is a system that accommodates both mutation and selection.
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Mutation, metamorphosis, over-population, unreal landscapes and objects are all themes that appear in his work.
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They then found a handful other individuals with similar symptoms as Quinn and the same mutation.
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What does a see-through fish with a genetic mutation have in common with a smoker?
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Not every mutation can be corrected in the same way as the one in the report.
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Curiously, scientists believe this mutation occurred after the development of agriculture — which made producing alcohol possible.
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Today, over 2156 generations later, the sickle cell mutation has been inherited by millions of people.
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Early genetic studies suggested that five different kinds of DNA, known as haplotypes, surround the mutation.
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The new study also offers hints as to how the mutation spread to millions of descendants.
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But malaria is rarer in southern Africa, and there the sickle cell mutation became rarer, too.
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Some West Africans captured in the slave trade brought the sickle cell mutation to the Americas.
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A few years ago, he discovered that the cancer was driven by a single gene mutation.
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It has a genetic mutation that makes it eat insatiably so that it gains weight rapidly.
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Their risk of diabetes and heart disease is 50 percent higher than those without the mutation.
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To bring the promise of mutation-directed therapies to life, researchers began two kinds of trials.
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The mutation was first identified in 21 in a secluded Amish farming community in Berne, Ind.
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This imperviousness to pain is what makes her distinct from everyone else with a FAAH mutation.
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The diagnosis was neurofibromatosis Type 2, a disease caused by an inherited or spontaneous genetic mutation.
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In women, however, the mutation was present in roughly the same fraction in both age groups.
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The mutation causing the brain defect is carried by a large Hispanic population in New Mexico.
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That mutation could have caused her trouble, because it encodes a protein that helps trigger heartbeats.
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As Kolata frames it: Would you want to know if you carried a fatal gene mutation?
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The worst part of the mutation," she said, "is that you burden your kids with this.
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But Dr. Stitziel and his colleagues discovered the mutation reduced heart attack risk by a third.
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The mutation appears in the genes serving as blueprints for antibodies made by white blood cells.
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Researcher said the children had all inherited the same genetic mutation from both of their parents.
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What if you have a disease-causing mutation you could pass on to your own kids?
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With gene editing, you're now just making one mutation in one gene in the simplest sense.
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Instead, a mutation occurred in a region of DNA that controlled the normal gene, hobbling it.
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We are having a difficult time just treating diseases that are caused by a single mutation.
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Most Africans have a mutation of this gene that doesn't allow it to be expressed in red blood cells, and therefore the parasite finds it difficult to get into the red blood cells of these individuals -- giving those with the mutation a high level of resistance.
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Each year, around 810 people are diagnosed in the UK, according to Cancer Research UK. While a genetic mutation plays a role in predisposing someone to the disease, just 1% of children born with this mutation go on to develop the disease, according to the paper.
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When someone has a rare MAOA gene mutation, it can cause MAOA deficiency or low-activity MAOA.
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He and his colleagues directed their attention to a specific kind of mutation called copy number variation.
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For a species whose numbers show no signs of collapsing, humans have a shockingly high mutation rate.
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Finally, the researchers sequenced part of the family's genomes, revealing a new mutation in the "ZFHX2" gene.
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The young patient at the center of the new study had a mutation to the gene LAMB3.
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This is opposed to another type of mutation called coding variants, which instead change a protein's structure.
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They found it took a single mutation to flip GK-PID from an enzyme to a carabiner.
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Supporters of this research argue that it's necessary to understand the threat posed by natural viral mutation.
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The genetic disorder stems from either a mutation or deletion of a gene on the 15th chromosome.
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There are many different mutations associated with human disease, and not every mutation is compatible with Cas9.
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One-third of acute myeloid leukemia patients have this mutation, which increases the chances of a relapse.
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Science hasn't established exactly how it helps treat hepatitis C, but it does drive mutation in viruses.
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Big brains, in other words, must have been useful in the context in which the mutation occurred.
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Raffan said that it's still possible to own a dog with this mutation and keep them slim.
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"This 'dream team' is working on the same mutation of cancer that my mom had," says Klein.
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Go deeper: The child described in the case study isn't the only person with a MDA5 mutation.
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My children and I were diagnosed with an extremely rare, life-threatening mutation of dysautonomic mitochondrial myopathy.
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That kind of mutation would thus make the offspring more or less adapted to a particular environment.
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Such is the obscurity of the disease that the mutation Charlie suffers from is called simply "RRM2B".
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The defect or disease arises when a mutation creates a mismatch between an organism and its environment.
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About two-thirds of the embryos ended up with two mutation-free copies of the targeted gene.
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This mutation, in the gene for a protein called myostatin, is found naturally in Belgian Blue cattle.
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The idea was to create "a compensating mutation" that would, in effect, cancel out the bad one.
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The differences in mutation patterns, they said, were strong enough to classify the groups as distinct species.
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Then she found out she had a genetic mutation that could increase her risk for breast cancer.
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Diamond, who tested positive for a BRCA2 mutation in 2013, took Color's test once it became available.
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The drug is intended for patients with retinal dystrophy due to a mutation of the RPE65 gene.
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For example, a researcher could look up how frequently a particular mutation occurs among the 10,000 people.
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The drug is already approved for use in patients aged 12 and older with a similar mutation.
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For example, suppose chickens are unisex and self-fertilize eggs, and most genetic mutation happens *around birth*.
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Or 336: the number of hours I had to wait to learn whether I had that mutation.
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But [scientists] think it must be something similar, a mutation that interferes with myostatin in some way.
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My genetic testing turned up a mutation that could, in theory, cause a form of mitochondrial disease.
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Mutation is a mundane aspect of existence for many viruses, and the novel coronavirus is no exception.
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Men with a mutation may suffer from breast, prostate or pancreatic cancers, or melanoma triggered by it.
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What we don't know is the specifics of where or when this recombination and other mutation occurred.
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Another type of mutation that's been spreading lately blocks malaria parasites from hanging out in the placenta.
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A few thousand years ago, a mutation popped up that prevented wisdom teeth from growing at all.
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Later, migrants spread the mutation across much of Africa and then to other parts of the world.
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The oldest version of the sickle cell mutation is found in people from western and central Africa.
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As people from different ancestries interbred, the mutation made its way further afield, into Europe and India.
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These people are carriers of a "homozygous" CCR5-delta 32 mutation, which renders them resistant to HIV.
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Jeremy won international fame for a mutation that caused his shell to coil left instead of right.
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At some point, she fell in love with Jason, "a mutation amplified with each reboot," Michael theorized.
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The mutation, described in the journal Science Advances, did not seem to have any effect on women.
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Among men, the mutation in the gene for growth hormone receptors was linked to substantially longer lives.
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When growth hormone levels surge, however, these cells divide faster than those in men without the mutation.
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Yet researchers have been saying for years that what matters was the genetic mutation causing the tumors.
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One in 12 African-Americans has sickle cell trait and are genetic carriers of the sickle mutation.
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Behind every property boom is a mutation of the eternal narrative about the scarcity value of land.
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She was interested in knowing whether they had a mutation of the MTHFR gene, as she does.
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And out of the 23 young people who had inherited the mutation, 18 had died sudden deaths.
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The researchers began by giving the flies the first mutation to arise in the ancestors of monarchs.
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It turned out that her tumor had an unusual mutation that made it vulnerable to the drug.
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But in the other three cells, the researchers found a mutation on one copy of the gene.
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Her saliva and urine also turned out to contain mosaic cells, some of which carried the mutation.
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One of the most pressing was how different kinds of cells were affected by a specific mutation.
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The remaining cases are inherited from a parent who carries a mutation in one or more genes.
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It also raises legitimate fears about a mutation making the virus more infectious as the outbreak spreads.
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Dr. Matei mentioned the BRCA mutation that multiplies my chances of metastases and my anxieties about them.
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The mysterious mutation they go through sterilizes them so they're unable to have kids of their own.
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The new research involved patients with relapsed or refractory AML who tested positive for the FLT20003 mutation.
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Radiation exposure has caused genetic damage and increased mutation rates in many organisms in the Chernobyl region.
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"So, introduce the human mutation in the mouse and ask if it does something bad," said Schimenti.
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It almost always affects men, passed down by a mutation on the X chromosome from their mother.
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He estimated the chance of clinical improvement of muscle function — defined as not having to constantly use a breathing machine — at 10 percent, but he acknowledged that the estimate derived from his work with patients with a mutation known as TK2, not the rarer mutation, RRM2B, that Charlie has.
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If you have the APC mutation you literally go up to between 0003 percent and 100 percent risk.
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