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"domain" Definitions
  1. an area of knowledge or activity; especially one that somebody is responsible for
  2. (computing) a set of websites on the internet that end with the same group of letters, for example ‘.com’, ‘.org’
  3. lands owned or ruled by a particular person, government, etc., especially in the past
  4. (mathematics) the range of possible values of a particular variableTopics Maths and measurementc2

1000 Sentences With "domain"

How to use domain in a sentence? Find typical usage patterns (collocations)/phrases/context for "domain" and check conjugation/comparative form for "domain". Mastering all the usages of "domain" from sentence examples published by news publications.

ME domain database, published a post explaining that they — and not a domain registrar like GoDaddy — had suspended the domain.
"Cyber, in its current magnitude, is a new domain of technology, a new domain of warfare, and a new domain of business," Levy said.
Though domain records can be falsified, it's unlikely here: the domain WHOIS entries make reference to MarkMonitor, an intermediary that protects brands from domain squatting.
The domain proved immensely profitable: according to Domain Tools, the number of active .
The Domain Name System (DNS) is what converts domain names into IP addresses.
ORG domain should respect the essential character of the users of the domain.
CloudFlare is launching a domain registry service — CloudFlare Registrar — that protects high-profile sites from domain hijackings and domain expiration (because they forgot to renew their domains).
When GoDaddy informed Gab that they no longer wanted to be its domain registrar, Gab was able to transfer its domain to a different domain name company.
XXX domain risked brand dilution (or worse) should someone else grab that domain first.
Domain registry site WHOIS shows that Apple now owns the online domain name www.Apple.
Dyn is a domain name provider, which maps domain names to corresponding IP addresses.
"Cyber, in its current magnitude, is a new domain of technology, a new domain of warfare, and a new domain of business," said Sygnia's Levy in a statement.
For instance, there's a weather domain, a hotels domain provided by Expedia, and a phone domain that each let Hound take your question or request and execute it.
"The first domain was essentially the same as the Israeli startup domain, but with an additional 's' added to the end of the domain name," Check Point said.
And so they came in and said we can see thousands of emails from the Clinton email domain including many, many, many from the Verizon Clinton domain, Blackberry domain.
Find and register domain names at a "domain registrar" such as Donuts, DirectNic, or Google .
This revealed the list of web domain names residing on the country's top level domain, .kp.
However, no longer only in the economic domain, but far into the social domain as well.
ICANN's policy on Domain Name Dispute Resolution essentially states that in the case of a domain dispute, the Losing Registrar (the registrar that maintained possession of the domain name pre-transfer, as opposed to the "Winning Registrar", who maintains possession of the domain name post-transfer).
It's unclear why Hopkins wanted the domain name or who he was transferring the domain name to.
Public Domain Pictures is a repository for those searching for a variety of free public domain images.
The Daily Stormer domain was then hosted briefly on the dark web before getting a Russian domain.
" The ad continues to criticize Trump for still today supporting eminent domain and flashes to clips of Trump calling eminent domain "wonderful" and saying "we have to use the power of eminent domain.
The "common" domain is for generic commands that could fit into more than one domain, the documents add.
TechCrunch's own research into the domain reveals that the domain owner has made every possible attempt to remain anonymous.
Starting with the public domain, agencies and others routinely offer and make available for a fee public domain works.
We gave a very extreme domain something in the range of £44,000 [$58,000] for that domain, but today polygamy.
He also had a note from Adams to the domain owner with directions on how to transfer the domain.
This tactic is called domain hopping or domain cycling and BuzzFeed News reported on it in March of this year.
So eminent domain — it's not that I love it, but eminent domain is absolutely — it's a necessity for a country.
For the non-domain prospectors out there, "sunrise period" refers to an early domain registration opportunity afforded to trademark holders.
According to a Whois, which displays domain registration information, The Daily Stormer switched its domain host to Google Monday morning.
Its primary job is to give official status to domain registrars and make sure they comply with domain ownership policies.
Domain records indicate that Weinstein's site was acquired by a Russian online marketer in 2015 after the domain was dropped.
TRUMP: Well, I think these people always hit me with eminent domain, and frankly, I'm not in love with eminent domain.
Public Domain: If any image was created in the United States prior to 1923 then they're part of the public domain.
But this isn't as easy as flipping a switch for custom domain names as you need certificates for all domain names.
This new domain registration service promises to only charge the wholesale price that the top-level domain registry (think Verisign) charges.
The silent evolution of domain names New domain extensions have accumulated some pretty big numbers over the last couple of years.
"The verification process for public domain [images] centers around running public domain data through reverse image searches," the co-founder said.
"If you have one domain, and the domain cost goes up by $1, it's not a big deal, obviously," said Nevett.
Shenzhenshi is "closely related" to Digital Domain and its Hong Kong-based parent company, Digital Domain Holdings, Rearden said in its countersuit.
On Sunday, the internet domain company GoDaddy refused to continue hosting the domain for a white supremacist website called the Daily Stormer.
Part of Facebook's response to domain cycling is to completely block the domain once it's been identified by third-party fact-checkers.
During the subject of eminent domain, Trump was resoundingly booed by the audience as he defended the use of eminent domain proceedings.
"It's not enough to have your domain knowledge or domain skills, maybe that's in business strategy maybe that's in accounting," says Fenlon.
Digital infrastructure entities covered by the directive include Internet exchange points, domain name system service providers and top level domain name registries.
The internet domain system: He acknowledged that the transition away from a U.S.-controlled domain name system is settled business for now.
The challenge is that while the domain changed, how we organize, acquire, equip, and train for that domain had not sufficiently changed.
If you own a domain, take the additional steps to authenticate email sent from that domain, even if you're using Google or Microsoft.
Anyone can monitor a domain name by proving that you actually own the domain name (otherwise it would be a potential security breach).
In addition to the changes in hosting-related services, 8chan's domain name is no longer listed with its former domain service provider, Tucows.
But it reappeared, its domain registered at Tucows through Njalla, a privacy-focused domain registry service that obscures the identity of the registrant.
Now, Musk has reclaimed a bit of that internet history for himself by purchasing the defunct domain name X.com from his former employer PayPal, which confirmed the purchase to Business Insider after internet domain blog Domain Investing reported on the purchase earlier today.
"DNS blocks are easy to circumvent, because site operators can just register a different domain name in the same top level domain or move to a different top level domain," Annemarie Bridy, Professor of Law at the University of Idaho told Motherboard.
In 1993, ICANN, the international group that regulates internet domain names, decided that single-letter domain names would no longer be available for sale.
The first few hours of Binary Domain are rough—rough enough that you might be thinking that playing Binary Domain is an elaborate ruse.
Domain names often function as malware command and control centers, so MalwareTech simply bought the domain name which triggered the kill switch for WannaCrypt.
I immediately transferred the domain into a different account and placed it (and all of my other domain names) on what amounted to lockdown.
Without a domain, it is next to impossible to have an online presence; there are now more than 350 million domain names registered worldwide.
The group's efforts include conducting human rights impact assessments (HRIAs) of domain management organizations (like the Dutch Internet domain registry SIDN, responsible for the .
Body language expert Carole Railton analyzed popular TED Talks for "Leadership Signals," a project for The U.K. Domain, the U.K.'s largest domain registry.
Some websites devoted to collections of public-domain films may simply link to content on YouTube anyway, as the Public Domain Flix site does.
Choosing a Domain Name When you feel ready to set up a website, the first thing you'll need to do is register a domain name.
Woodhead likened the Yahoo group to DNS, the Domain Name System, which is the internet system that associates information like IP addresses with domain names.
The cousin drove to the domain owner's house and provided a demand note, which contained instructions for transferring the domain to Adams, court records show.
Check to see if the domain is availableThere are several ways to check and see if the domain of your choice is up for grabs.
Paine said Cloudflare still receives a handful of requests to take down the domain each year, thinking the domain is spreading WannaCry — not preventing it.
The silent evolution of domain names Verisign recently  reported that the number of registered dot-com domain names exceeded 128 million for the first time.
Orion Span Tagline: The World's Private Space Station Describes itself as: What was once the domain of governments is now the domain of private industry.
We reached out to GoDaddy, the domain registrar for the company's main site, as well as the leaky database, which is on the same domain.
Despite its popularity, the annual price for registering the domain has been capped at $9.05, making it much more accessible than most other domain endings.
As an early domain name investor, Cai "found it frustrating to have to type domain names in English," according to a 2265 Wall Street Journal profile.
Search results on Fiverr, the service marketplace, for "Domain authority 40+""Any domain that has SEO value is going to get grabbed up automatically," he added.
The AP found that one purported CIA hack that imitates the Domain Name System — the internet's phone book — traced to an internet domain hosted in Germany.
If you have a common name or want to buy a domain that includes common words, you'll have make an offer through a domain name brokerage.
Notably, only one other domain has previously resolved to the same IP address as the fake FedEx page; a domain that eludes to a law firm.
DOMAIN SPIN-OFF Long-suffering shareholders had pinned their hopes on Fairfax's plan to spin off Domain as it continues to cut costs at its newspapers.
ICANN, the organization that oversees and manages IP addresses and the domain name system, approved of the new general top-level domain name extensions in 2011.
When we punch a domain name into our browser, it's fired out to a Domain Name System (DNS) server, which translates it into the corresponding number.
"You see malicious activity related to a domain name and your first reflex is to see who's behind this domain," Mertens told me in an email.
Le Roux developed his own domain registrar, which meant that if a website got shut down, he could just generate another domain address on his own.
On the contrary, they have the constitutional right to proclaim and act on their religious beliefs in the public domain, including in the domain of commerce.
When the president stated openly that space is a warfighting domain, and we have to dominate that domain just like we do with every other domain, it opened the aperture for us to talk about what we as a service have been passionate about for years.
A month later, with the domain owner still unwilling to lower his asking price, Adams drove his cousin, Sherman Hopkins Jr., 43, to the domain owner's home.
As Johnson explained to me over email, since bids on domain names are sealed, no one can know for sure which domain names a person bet on.
Catch up quick: DNS — A domain name service (DNS) that operates like an internet phonebook, converts domain names entered by users into internet addresses read by machines.
Here's what you'll be getting: Patterns, Principles, and Practices of Domain-Driven Design Before you even begin your programming journey, you must first understand domain-driven design.
The fact that only a single domain name was coded into the malware meant that registering that domain name had the effect of shutting down WannaCrypt worldwide.
If the servers were only meant to talk to each other, why not connect directly, storing the IP-domain link locally and skipping public domain registration entirely?
These additional domains include domain present in ubiquitin-specific proteases (DUSP) domain; ubiquitin-like (UBL) domain; meprin and TRAF homology (MATH) domain; zinc- finger ubiquitin-specific protease (ZnF-UBP) domain; zinc-finger myeloid, nervy and DEAF1 (ZnF-MYND) domain; ubiquitin-associated (UBA) domain; CHORD- SGT1 (CS) domain; microtubule-interacting and trafficking (MIT) domain; rhodenase-like domain; TBC/RABGAP domain; and B-box domain.
Summary: Euclidean domain => principal ideal domain => unique factorization domain => integral domain => Commutative ring.
RasGAP contains one SH3 domain and two SH2 domains, a PH domain, a C2 domain, and a GAP domain.
The C-terminal module is a PH-like domain. The FERM domain has also been called the amino-terminal domain, the 30kDa domain, 4.1N30, the membrane- cytoskeletal-linking domain, the ERM-like domain, the ezrin-like domain of the band 4.1 superfamily, the conserved N-terminal region, and the membrane attachment domain.
The N-terminal domain corresponds to the FAD ADP- binding domain, the C-terminal domain is a steroid-binding domain.
NTD = N-terminal SNX domain, PX = PX domain, CTD = C-terminal BAR domain.
All four lecticans contain an N-terminal globular domain (G1 domain) that in turn contains an immunoglobulin V-set domain and a Link domain that binds hyaluronic acid; a long extended central domain (CS) that is modified with covalently attached sulfated glycosaminoglycan chains, and a C-terminal globular domain (G3 domain) containing of one or more EGF repeats, a C-type lectin domain and a CRP-like domain. Aggrecan has in addition a globular domain (G2 domain) that is situated between the G1 and CS domains.
Subsequently, "Further down memory lane: Domain" was prepared by the Domain History Book Committee in 2002. Domain, Man. : Domain History Book Committee, 2002.
The second variant lacks a region of the extracellular domain between the fourth FNIII domain and the transmembrane domain and in the juxtamembrane domain.
The AspAT-like small domain, the PLP-binding domain, and the carboxy-terminal domain form an open bowl-like structure. The wing domain extends from the other three domains like a handle of the bowl, and the linker domain connects these two parts together. Altogether, the five domains associate with one another through hydrogen bonds and electrostatic interactions. Arginine Decarboxylase Monomer showing: (A) Wing domain (purple); (B) linker domain (red); (C) PLP-binding-domain (orange); (D) AspAT-like small domain (blue); (E) carboxy-terminal domain (green).
There are two types of stalk domain: the FGG domain and the right-handed stalk domain.
In ISPL the terms target domain and service domain are used quite frequently. Target domain The target domain is the part of the customer organization that is affected by the service. Service domain The service domain is the service organization that delivers the service, i.e. the supplier.
A search domain is a domain used as part of a domain search list. The domain search list, as well as the local domain name, is used by a resolver to create a fully qualified domain name (FQDN) from a relative name. For this purpose, the local domain name functions as a single-item search list.
His son,Matsudaira Naomori was transferred to Murakami Domain (1649), back to Himeji Domain (1667), Hita Domain (Bungo Province) (1682), Yamagata Domain (1686) and Shirakawa Domain (1692). Naomori's grandson, Matsudaira Akinori was transferred to Himeji Domain in 1741. His son, Matsudaira Tomonori, was transferred to Maebashi Domain in 1749 and rebuilt the Maebashi Tōshō-gū on its present site.
Domain 1 is composed of 10 alpha helices, domain 2 of 9, and domain 3 of 4.
The opposite of inter-domain routing is intra-domain routing, routing within a domain or an autonomous system.
Every irreducible element of a GCD domain is prime. A GCD domain is integrally closed, and every nonzero element is primal.proof that a gcd domain is integrally closed, PlanetMath.org In other words, every GCD domain is a Schreier domain.
On the other hand, the C-terminal PAW domain (a domain present in PNGases and other worm proteins). has now been shown to be involved in the binding of oligosaccharides to PNGase. In terms of the crystal structures of mouse Ngly1, a catalytic core domain, a C-terminal domain including PAW domain and an N-terminal domain including PUB domain. have been obtained.
LIM domain only protein 7 is a protein that in humans is encoded by the LMO7 gene. This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain. An F-box (FBX) domain is present in alternative splice variants. Members of the LIM protein family carry the LIM domain, a unique cysteine-rich zinc-binding domain.
Today, the Internet Corporation for Assigned Names and Numbers (ICANN) manages the top-level development and architecture of the Internet domain name space. It authorizes domain name registrars, through which domain names may be registered and reassigned. The hierarchical domain name system, organized into zones, each served by domain name servers. The domain name space consists of a tree of domain names.
In the Domain Name System (DNS) hierarchy, a second-level domain (SLD or 2LD) is a domain that is directly below a top-level domain (TLD). For example, in `example.com`, `example` is the second-level domain of the `.com` TLD.
MAM domain is an evolutionary conserved protein domain. It is an extracellular domain found in many receptors. A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu) domain, has been recognised in the extracellular region of functionally diverse proteins. These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain.
The Owari Domain was supported by the Yanagawa Domain in Mutsu Province and the Takasu Domain in Mino Province.
Domain controllers are typically deployed as a cluster to ensure high-availability and maximize reliability. In a Windows environment, one domain controller services as the Primary Domain Controller (PDC) and all other servers promoted to domain controller status in the domain server as a Backup Domain Controller (BDC). In Unix-based environments, one machine serves as the master domain controller and others serve as replica domain controllers, periodically replicating database information from the main domain controller and storing it in a read- only format.
The extended EGL-27 and MTA1 homology domain, or EELM2 domain, is a protein domain that occurs in proteins from apicomplexan parasites. Part of the EELM2 domain is homologous to the ELM2 domain, but is 'extended' in that its boundaries (the region of conservation) are longer than in the ELM2 domain. Currently (as of 2012), little is known about the function of this domain. However, some proteins that contain an EELM2 domain also contain a PHD finger domain, which is thought to be involved in chromatin remodelling.
Finally, if R is not Noetherian, then there exists an infinite ascending chain of finitely generated ideals, so in a Bézout domain an infinite ascending chain of principal ideals. (4) and (2) are thus equivalent. A Bézout domain is a Prüfer domain, i.e., a domain in which each finitely generated ideal is invertible, or said another way, a commutative semihereditary domain.) Consequently, one may view the equivalence "Bézout domain iff Prüfer domain and GCD-domain" as analogous to the more familiar "PID iff Dedekind domain and UFD".
A structure of GAK was determined using X-ray diffraction to a resolution of 2.10 Å. Cyclin G-associated kinase is a two domain cystolic protein. The domain of interest is the C-terminal domain which consists of three subdomains such as a C-terminal J domain, a clathrin-binding domain, and a tension-like N-terminal domain. The other domain is the N terminal kinase domain which is a functional Ser/Thr protein kinase. The N-terminal kinase domain is able to phosphorylate histone H1.
A domain name registrar is a company that manages the reservation of Internet domain names. A domain name registrar must be accredited by a generic top- level domain (gTLD) registry or a country code top-level domain (ccTLD) registry. A registrar operates in accordance with the guidelines of the designated domain name registries.
RNF128 contains a N-terminal PA domain (residues 75–183) and a C-terminal RING finger domain domain (residues 277–318). A crystallographic structure of the PA domain has been determined.
A doppelganger domain is a domain spelled identical to a legitimate fully qualified domain name (FQDN) but missing the dot between host/subdomain and domain, to be used for malicious purposes.
A private sub-domain registry allocates domain names in a subset of the Domain Name System under a domain registered with an ICANN-accredited or ccTLD registry. Most of the private sub-domain registries operate based on an ISO 3166-1 name that is a subdomain of a higher-level domain. Some of these registries combine the domain registry and the domain registrar functions in the administration structure, while others distribute domains via third-party registrars.
Domain analysis is used to define the domain, collect information about the domain, and produce a domain model. Through the use of feature models (initially conceived as part of the feature-oriented domain analysis method), domain analysis aims to identify the common points in a domain and the varying points in the domain. Through the use of domain analysis, the development of configurable requirements and architectures, rather than static configurations which would be produced by a traditional application engineering approach, is possible. Domain analysis is significantly different from requirements engineering, and as such, traditional approaches to deriving requirements are ineffective for development of configurable requirements as would be present in a domain model.
It operates under multiple re-seller names, such as Domain Registry of America, Domain Registry of Australia, Domain Registry of Canada, Domain Registry of Europe, Domain Renewal Group, Internet Corporation Listing Service, Internet Registry of Canada, Liberty Names of America, Registration Services Inc., Yellow Business.ca.
All subunits have a shared architecture with four domain layers: two extracellular clamshell domains called the N-terminal domain (NTD) and ligand-binding domain (LBD; which binds glutamate), the transmembrane domain (TMD) that forms the ion channel, and an intracellular C-terminal domain (CTD).
Service domain deliverables describe the service domain (see paragraph #Target domain and service domain for more information). They are delivered by both customer and supplier organisations to plan and control services. There are two types of service domain deliverables: service plans and service reports.
In 1662, Muneyoshi was transferred to the newly- created Iwanuma Domain in the Natori District, becoming daimyō of a subsidiary domain to Sendai Domain. In 1695, his son Tamura Tatsuaki, transferred the seat of the domain to Ichinoseki Domain (30,000 koku). The clan remained at Ichinoseki until the Meiji restoration. The Ichinoseki holdings were completely surrounded by Sendai Domain.
A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalytic domain. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination.
Smad proteins contain two conserved domains. The Mad Homology domain 1 (MH1 domain) is at the N-terminal and the Mad Homology domain 2 (MH2 domain) is at the C-terminal. Between them there is a linker region which is full of regulatory sites. The MH1 domain has DNA binding activity while the MH2 domain has transcriptional activity.
Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.
Similar to other caspases, caspase-9 has three domains: N-terminal pro-domain, large subunit, and a small subunit. The N-terminal pro-domain is also called the long pro-domain and this contains the caspase activation domain (CARD) motif. The pro-domain is linked to the catalytic domain by a linker loop. The caspase-9 monomer consists of one large and one small subunit, both comprising the catalytic domain.
Common uses of defaults: $ defaults read DOMAIN # gets all $ defaults read DOMAIN PROPERTY_NAME # gets $ defaults write DOMAIN PROPERTY_NAME VALUE # sets $ defaults delete DOMAIN PROPERTY_NAME # resets a property $ defaults delete DOMAIN # resets preferences DOMAIN should be replaced by the plist file name sans extension ('.plist'). plist files are named with reverse domain name notation. For example: $ defaults read com.apple.iTunes # prints all iTunes preference values plist files store keys and values.
Characteristic for ATM are five domains. These are from N-terminus to C-terminus the HEAT repeat domain, the FRAP-ATM-TRRAP (FAT) domain, the kinase domain (KD), the PIKK-regulatory domain (PRD) and the FAT-C-terminal (FATC) domain. The HEAT repeats directly bind to the C-terminus of NBS1. The FAT domain interacts with ATM's kinase domain to stabilize the C-terminus region of ATM itself.
Cyclosporin biosynthesis. Bmt = butenyl-methyl- threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine Cyclosporin is synthesized by a nonribosomal peptide synthetase, cyclosporin synthetase. The enzyme contains an adenylation domain, a thiolation domain, a condensation domain, and an N-methyltransferase domain. The adenylation domain is responsible for substrate recognition and activation, whereas the thiolation domain covalently binds the adenylated amino acids to phosphopantetheine, and the condensation domain elongates the peptide chain.
TRIM25 has an N-terminal RING domain, followed by a B-box type 1 domain, a B-box type 2 domain, a coiled-coil domain (CCD) and a C-terminal SPRY domain. The RING domain coordinates two zinc atoms and is essential for recruiting ubiquitin- conjugating enzymes. The function of the B-box domains is unknown. The CCD domain has been implicated in multimerization and other protein-protein interactions.
NLRs contain 3 domains – central NACHT (NOD or NBD – nucleotide-binding domain) domain, which is common to all NLRs, most of NLRs have also C-terminal leucine-rich repeat (LRR) and variable N-terminal interaction domain. NACHT domain mediates ATP-dependent self-oligomerization and LRR senses the presence of ligand. N-terminal domain is responsible for homotypic protein-protein interaction and it can consist of caspase recruitment domain (CARD), pyrin domain (PYD), acidic transactivating domain or baculovirus inhibitor repeats (BIRs).
Calpain-10 is a protein that in humans is encoded by the CAPN10 gene. Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The typical calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain.
MEF2-like MADS-domain proteins in animals and fungi have the MEF2 domain as a second conserved domain. In plants, the MEF2-like MADS-domain proteins are also termed MIKC- type proteins referring to their conserved domain structure, where the MADS (M) domain is followed by an Intervening (I), a Keratin-like (K) and a C-terminal domain. In plants, MADS-domain protein form tetramers and this is thought to be central for their function. The structure of the tetramerisation domain of the MADS-domain protein SEPALLATA3 was solved illustrating the structural basis for tetramer formation A geneticist intensely investigating MADS-box genes is Günter Theißen at the University of Jena.
A bounded domain is a domain which is a bounded set, while an exterior or external domain is the interior of the complement of a bounded domain. In complex analysis, a complex domain (or simply domain) is any connected open subset of the complex plane ℂ. For example, the entire complex plane is a domain, as is the open unit disk, the open upper half-plane, and so forth. Often, a complex domain serves as the domain of definition for a holomorphic function. In the study of several complex variables, the definition of a domain is extended to include any connected open subset of ℂn.
Typical TagU proteins are made up of an N-terminal transmembrane domain (for anchoring), an optional, non-conserved accessory domain (CATH 3tflA01), a core catalytic domain, and sometimes a C-terminal domain for which the structure is unknown. The core LCP domain is a magnesium- dependent enzyme.
CNNIC is responsible for operating and administering China’s domain name registry. CNNIC manages both the ".cn" country code top level domain and the Chinese Domain Name system (Internationalized domain names that contain Chinese characters). As of June 2015, the total number of Chinese domain names is 22,310,000.
The core domains of PAK4 include, a kinase domain in the C-terminal region, a p21-binding domain (PBD), and a newly defined auto-inhibitory domain (AID) or an AID-like pseudosubstrate sequence (PS) domain.
Domain drop catching, also known as domain sniping, is the practice of registering a domain name once registration has lapsed, immediately after expiry.
NODs subfamily consists of NOD1, NOD2, NOD3, NOD4 with CARD domain, CIITA containing acidic transactivator domain and NOD5 without any N-terminal domain.
VSPs are made up of two protein domains: a voltage sensor domain, and a phosphatase domain coupled to a lipid-binding C2 domain.
Domain registration is directly at the second level, and is managed by the HM Domain Registry. Any entity can register an .hm domain.
Raf-like Ras-binding domain is an evolutionary conserved protein domain. This is the Ras-binding domain found in proteins related to Ras.
In particular, an atomic Schreier domain is a unique factorization domain; this generalizes the fact that an atomic GCD domain is a UFD.
This domain is yet to be assigned to any domain superfamily.
Each domain must be registered in the National Domain Name Registry.
Domain parking is the registration of an Internet domain name without that domain being associated with any services such as e-mail or a website. This may have been done with a view to reserving the domain name for future development, and to protect against the possibility of cybersquatting. Since the domain name registrar will have set name servers for the domain, the registrar or reseller potentially has use of the domain rather than the final registrant. Domain parking can be classified as monetized and non-monetized.
The VASt domain structurally resembles a truncated form of a START domain, but with limited sequence similarity. While VASt is a member of the Bet v1-like superfamily, it is unclear if it evolved from the same ancestral domain as the START domain or is an example of convergent evolution. The domain is highly conserved across all eukaryotes and is typically present in only one copy in VASt domain-containing proteins. Like the START domain, the VASt domain consists of a helix-grip fold structure.
The .mobi premium generic words and phrases list is a good example of the domain names that are at the heart of most early-market domain name speculation. Domain name speculators, sometimes known as domainers or domain investors, also register domain names based on seemingly generic phrases such as propertyforsale in the hope that these domain names could be sold later to businesses. Some (but not all) domain name investors will try to stay away from domain names containing trademarks as this could be considered cybersquatting.
Since a function is defined on its entire domain, its domain coincides with its domain of definition. However, this coincidence is no longer true for a partial function, since the domain of definition of a partial function can be a proper subset of the domain. A domain is part of a function if is defined as a triple , where is called the domain of , its codomain, and its graph. A domain is not part of a function if is defined as just a graph.
Introns vary in size between 0.7 and 26 kb. Like other nuclear receptors, the AR protein consists of several functional domains: the transactivation domain (also called the transcription-regulation domain or the amino / NH2-terminal domain), the DNA-binding domain, the hinge region, and the steroid-binding domain (also called the carboxyl-terminal ligand-binding domain). The transactivation domain is encoded by exon 1, and makes up more than half of the AR protein.
In a Windows domain, the directory resides on computers that are configured as domain controllers. A domain controller is a Windows or Samba server that manages all security-related aspects between user and domain interactions, centralizing security and administration. A domain controller is generally suitable for networks with more than 10 PCs. A domain is a logical grouping of computers.
This results in a much shorter N-terminus in isoform 2. Isoform 1 is used more often when analyzing the protein. Isoform 1 includes a signal peptide, protease associated domain, transmembrane domain, and a RING zinc finger domain. Isoform 2 does not contain the same signal peptide or protease associated domain, but does include a similar transmembrane domain and RING zinc finger domain.
Spanning from amino acid 1886 until amino acid 1983, this domain is referred to as a Pleckstrin Homology domain in the BEACH domain. It has a PH because the fold of this domain is similar to the PH domain, but is not identical in the sequence of the canonical PH domains. The PH_BEACH domain is not able to bind phospholipids.
Domain name scams are types of Intellectual property scams or confidence scams in which unscrupulous domain name registrars attempt to generate revenue by tricking businesses into buying, selling, listing or converting a domain name. The Office of Fair Trading in the United Kingdom has outlined two types of domain name scams which are "Domain name registration scams" and "Domain name renewal scams".
The inverse Fourier transform converts the frequency-domain function back to the time-domain function. A spectrum analyzer is a tool commonly used to visualize electronic signals in the frequency domain. Some specialized signal processing techniques use transforms that result in a joint time–frequency domain, with the instantaneous frequency being a key link between the time domain and the frequency domain.
Example of a DNA-binding domain in the context of a protein. The N-terminal DNA-binding domain (labeled) of Lac repressor is regulated by a C-terminal regulatory domain (labeled). The regulatory domain binds an allosteric effector molecule (green). The allosteric response of the protein is communicated from the regulatory domain to the DNA binding domain through the linker region.
The N domain serves as a built-in protein kinase that functions to phosphorylate the P domain. The N domain is inserted between the two segments of the P domain, and is formed of a seven-strand antiparallel β-sheet between two helix bundles. This domain contains the ATP- binding pocket, pointing out toward the solvent near the P-domain.
Class II enzymes lack a membrane domain. Their catalytic region is structurally related to that of class I enzymes, but it consists of only two domains: a large L-domain and a small S-domain (inserted within the L-domain). As with class I enzymes, the L-domain binds substrate, but the S-domain binds NAD (instead of NADP in class I).
Within the SDF domain time does not exists. Another data driven domain is the DDF Domain (Dynamic Data Flow). Whereas in the SDF domain the generating and consuming rates are fixed, the rates in the DDF domain are variable, which allows a dynamical change of the data processing.
The Arabic top-level domain ' (meaning ".web", and transcribed into English as ".shabaka") is an internationalized domain name top-level domain in the Domain Name System of the Internet for Arabic language websites. Websites using the domain can be accessed using its U-label () or A-label equivalent ().
A nonzero ring with no nonzero zero-divisors is called a domain. A commutative domain is called an integral domain. The most important integral domains are principal ideals domains, PID for short, and fields. A principal ideal domain is an integral domain in which every ideal is principal.
CDC37 consists of three structural domains. The N-terminal domain binds to protein kinases. The central domain is the Hsp90 chaperone (heat shock protein 90) binding domain. The function of the C-terminal domain is unclear.
According to RFC 1034, "a domain is a subdomain of another domain if it is contained within that domain". Based on that definition, a host cannot be a subdomain, only a domain can be a subdomain.
The SBDS protein contains three domains, an N-terminal conserved FYSH domain, central helical domain and C-terminal domain containing an RNA-binding motif.
The Takasu Domain also provided 30,000 koku to the Owari Domain annually from 1700 to 1870, when it was merged with the Owari Domain.
FHAD1 has 4 aliases, Forkhead associated phosphopeptide binding domain 1, Forkhead-associated (FHA) phosphopeptide binding domain 1, FHA Domain-Containing Protein 1, and KIAA1937.
This protein consists of two protein domain. One is a large, globular N-terminal domain and the other is a smaller C-terminal domain.
Both replicate to all domains in the Forest. The 'Domain' partition holds all objects created in that domain and replicates only within its domain.
Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major protein domain of many blood coagulation factors. Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to the C2 domain). In the Dictyostelium discoideum (Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins.
VII §1 no. 3 th. 2 A polynomial ring over a Mori domain need not be a Mori domain. Also, the complete integral closure of a Mori domain need not be a Mori (or, equivalently, Krull) domain.
The MMPs have a common domain structure. The three common domains are the pro-peptide, the catalytic domain, and the haemopexin- like C-terminal domain, which is linked to the catalytic domain by a flexible hinge region.
Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene. Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain.
The domain name .рф (romanized as .rf;Rossia.rf becomes first Cyrillic domain, RIA Novosti, 25 November 2009 abbreviation of ) is the Cyrillic country code top-level domain for the Russian Federation, in the Domain Name System of the Internet. In the Domain Name System it has the ASCII DNS name .
In molecular biology, the YEATS domain is a protein domain found in a variety of proteins from eukaryotic organisms. YEATS domain proteins are found in a variety of chromatin modification molecular complexes. Structurally the domain has an immunoglobulin like fold. The YEATS domain has shown to bind to acetyllysine protein modifications.
The domain expert only needs to specify the domain specific constructs and rules, and the domain-specific language environment provides a modeling tool tailored for the target domain. Most existing domain-specific language takes place with domain- specific language environments, either commercial such as MetaEdit+ or Actifsource, open source such as GEMS, or academic such as GME. The increasing popularity of domain-specific language has led to domain-specific language frameworks being added to existing IDEs, e.g. Eclipse Modeling Project (EMP) with EMF and GMF, or in Microsoft's DSL Tools for Software Factories.
ABD, adaptor-binding domain; RDB, Ras-binding domain. P110δ contains at least five domains (figure 1): adaptor-binding domain, a Ras GTPase-binding domain, a PI(3)K-type C2 domain, helical domain, and a kinase domain. Mutations have been identified in multiple domains, although there seems to be a recurrent transition mutation (G>A causing E1021K) in the C lobe of the kinase domain, leading to constitutive activation of enzyme function. Specific p110δ mutants cause stronger binding to membranes and relieve inhibition of the kinase by regulatory proteins.
STARD3 is a multi-domain protein composed of a N-terminal MENTAL (MLN64 N-terminal) domain, a central FFAT motif (two phenylalanines in an acidic tract), and a C-terminal StAR-related transfer domain (START) lipid transport domain. The MENTAL domain of STARD3 is similar to the protein STARD3 N-terminal like protein (STARD3NL) also known as MLN64 N-terminal homologue (MENTHO). This domain is composed of 4 transmembrane helices which anchor the protein in the limiting membrane of late endosomes. This domain binds cholesterol and associates with the same domain in STARD3NL.
DTWD1, DTW domain containing 1, is a human gene. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named.
The Yanagawa Domain provided 30,000 koku to the Owari Domain annually from 1683 to 1730, when Tokugawa Muneharu came to power and dissolved the domain.
In an IPv4 environment, search domains are often set via DHCPv4, along with the local domain name. The domain search list is configured by the Domain Search Option (DHCPv4 option number 119), while the local domain name is configured by Domain Name (DHCPv4 option number 15). The Windows operating system, however, does not understand the Domain Search Option; as a workaround, many network administrators use Group Policy Objects to set the domain search list for Windows machines.
Figure 4: HPI Domain-level functionality. User programs access HPI-based platform management by opening a Session with a Domain. The user program may open a Session with a specific Domain by specifying a Domain Identifier, or more commonly, it may open a Session with a default Domain. With a Session established, the user program may access various Domain-level functions, or it may access any of the Resources that are currently listed as members of the Domain.
The 3D crystal structure of human POR has been determined.); The molecule is composed of four structural domains: the FMN-binding domain, the connecting domain, the FAD-binding domain, and NADPH-binding domain. The FMN-binding domain is similar to the structure of FMN-containing protein flavodoxin, whereas the FAD-binding domain and NADPH-binding domains are similar to those of flavoprotein ferredoxin-NADP+ reductase (FNR). The connecting domain is situated between the flavodoxin-like and FNR-like domains.
The extracellular domain (residues 32-692) contains the E1 domain, E2 domain, and BPTI/Kunitz inhibitor domain. The E1 domain contains two independent folding units, the growth factor-like domain (GFLD) and the copper-binding domain (CuBD). GFLD has a highly charged basic surface and a highly flexible region consisting of an N-terminal loop formed by a disulphide bridge. CuBD consists of an alpha-helix that is tightly packed on a triple-stranded beta-sheet.
The hepadnaviral P protein is organized into three domains: an N-terminal domain () covering the terminal and the spacer, an RT domain related to every other RT domain, and a C-terminal domain () regulating the RNase H activity.
The business of resale of registered domain names is known as the domain aftermarket. Various factors influence the perceived value or market value of a domain name. Most of the high-prize domain sales are carried out privately.
The main branch of the Inoue clan was transferred numerous times throughout the Edo period. Inoue Masanari (1577–1628), the 3rd son of Inoue Kiyohide, was made daimyō of Yokosuka Domain (53,000 koku) in Tōtōmi Province in 1623. His descendants resided at Kasama Domain, Hitachi Province in 1645, Gujo Domain in Mino Province in 1692, Kameyama Domain in Tanba Province in 1697, Shimodate Domain in Hitachi Province in 1702, back to Kasama Domain in Hitachi in 1703, and then to Iwakidaira Domain in Mutsu Province in 1747. Subsequently, they were transferred to Hamamatsu Domain in Tōtōmi Province in 1758, Tanakura Domain in Mutsu Province in 1817, Tatebayashi Domain in Kōzuke Province in 1836, back to Hamamatsu in 1845 and finally to Tsurumai Domain in Kazusa Province in 1868.
Lastly, the third domain, which is known as the "thumb domain", interacts with double stranded DNA. The exonuclease domain contains its own catalytic site and removes mispaired bases. Among the seven different DNA polymerase families, the "palm domain" is conserved in five of these families. The "finger domain" and "thumb domain" are not consistent in each family due to varying secondary structure elements from different sequences.
In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase , which mediates membrane association. This domain is found in a variety of membrane or lipid associated proteins.
The top-level domains (TLDs) such as com, net and org are the highest level of domain names of the Internet. Top-level domains form the DNS root zone of the hierarchical Domain Name System. Every domain name ends with a top-level domain label. When the Domain Name System was devised in the 1980s, the domain name space was divided into two main groups of domains.
Type IA topoisomerases have several domains, often number Domain 1-4. Domain I contains a Toprim domain (a Rossman fold known to coordinate Magnesium ions), domain IV and domain III each consist of a helix- turn-helix (HTH) domain; the catalytic tyrosine resides on the HTH of domain III. Domain II is a flexible bridge between domains III and IV. The structure of type IA topoisomerase resembles a lock, with Domains I, III and IV lying on the bottom of the structure. The structure of topo III (see below) bound to single-stranded DNA (pdb id = 1I7D) shows how the HTH and Toprim domain are coordinated about the DNA.
Takasu Domain was revived in 1640 as a 22,000 koku holding for a cadet branch of the Ogasawara clan from Sekiyado Domain in Shimōsa. However, the domain suffered greatly from flood damage, and the shogunate transferred the Ogasawara to Katsuyama Domain in Echizen in 1691. The domain was revived a third time in 1700, this time as a 30,000 koku holding for Matsudaira Yoshiyuki, the younger son of Tokugawa Mitsutomo of Owari Domain. Matsudaira Yoshiyuki was already daimyō of the 30,000 koku Takai Domain in Mino Province since 1681, and traded this territory of Takasu Domain, which then became a subsidiary to Owari Domain.
Nanbu Nobuyuki was born as the 14th son of Shimazu Shigehide, daimyō of Satsuma Domain. In 1838, Hachinohe Domain made it known that it was looking for an heir to Nanbu Naomasa. Approaches were made to Nakatsu Domain, Fukuoka Domain and Maruoka Domain, but with the small kokudaka of Hachinohe Domain, there was no interest; however, in Satsuma Domain there was a surfeit of male heirs and the domain was looking to both expand its influence and to cut its expenses. In 1838, his adoption was official recognised in a formal audience with Shōgun Tokugawa Ieyoshi and he became daimyō of Hachinohe Domain in 1842 on the death of Nanbu Nobumasa.
The first two domains contribute to the embryo proper. The apical embryo domain, gives rise to the shoot apical meristem and cotyledons. The second domain, the central embryo domain, gives rise to the hypocotyl, root apical meristem, and parts of the cotyledons. The third domain, the basal embryo domain, contains the hypophysis.
In 2010 a new top domain was registered and introduced for Thailand, intended for domain names in the local language. This top domain is . As of 2011, thousands of sites with this domain are active. It appears that the Thai second-level domains are assigned directly to sites with English domain names.
EpCAM consists of an extracellular domain (242 amino acids) with epidermal growth factor (EGF)- and thyroglobulin repeat-like domains, a single transmembrane domain (23 amino acids), and a short intracellular domain (26 amino acids). The extracellular domain is sometimes referred to as EpEX, and the intracellular domain is sometimes referred to as EpICD.
Transmembrane domain usually denotes a transmembrane segment of single alpha helix of a transmembrane protein. More broadly, a transmembrane domain is any membrane-spanning protein domain.
For example, the YEATS domain of yeast Af9 protein. The YEATS domain has shown to be a reader domain for the protein modification of lysine crotonylation.
Anemic domain model is the use of a software domain model where the domain objects contain little or no business logic (validations, calculations, business rules etc.).
In the Bok-S variant, the BH3 domain is truncated and fused to the shortened BH1 domain. Another known variant, Bok-P, lacks the BH4 domain and contains a truncated BH3 domain. The shorter version, Bok-S, lacks exon 3.
In the Domain Name System (DNS) hierarchy, a subdomain is a domain that is a part of another (main) domain. For example, if a domain offered an online store as part of their website `example.com`, you might use the subdomain `shop.example.com` .
The autochaperone domain is usually located between the HSF and the passenger domain. When the passenger domain is translocated, starting with its C terminus, the autochaperone domain is first out. This would result in the formation of a hairpin structure.
An example of an operational domain name with four levels of domain labels is sos.state.oh.us. Each label is separated by a full stop (dot). 'sos' is said to be a sub-domain of 'state.oh.us', and 'state' a sub-domain of 'oh.
WD40 repeat domain of beta-TrCP (green), leucine-rich repeat domain of TLR2 (red), armadillo repeat domain of beta-catenin (blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta). Solenoid protein domains are a highly modular type of protein domain. They consist of a chain of nearly identical folds, often simply called tandem repeats. They are extremely common among all types of proteins, though exact figures are unknown.
Each of these modules can catalyze activation, condensation and a modification reaction specific to one kind of amino acid. A typical elongation module consists of an adenylation domain (A), a peptidyl carrier protein domain (PCP) and a condensation domain (C). Some other domains may be present that are responsible for modifications to the residues, such as epimerization domain (E) and N-methyltransferase domain (MT). The domain responsible for the termination is the thioesterase domain (TE) located in the final module.
Domain hijacking can be done in several ways, generally by unauthorized access to, or exploiting a vulnerability in the domain name registrar's system, through social engineering, or getting into the domain owner's email account that is associated with the domain name registration. A frequent tactic used by domain hijackers is to use acquired personal information about the actual domain owner to impersonate them and persuade the domain registrar to modify the registration information and/or transfer the domain to another registrar, a form of identity theft. Once this has been done, the hijacker has full control of the domain and can use it or sell it to a third party. Other methods include email vulnerability, vulnerability at the domain-registration level, keyloggers, and phishing sites.
A domain model is a type of conceptual model used to depict the structural elements and their conceptual constraints within a domain of interest (sometimes called the problem domain). A domain model includes the various entities, their attributes and relationships, plus the constraints governing the conceptual integrity of the structural model elements comprising that problem domain. A domain model may also include a number of conceptual views, where each view is pertinent to a particular subject area of the domain or to a particular subset of the domain model which is of interest to a stakeholder of the domain model. Like entity–relationship models, domain models can be used to model concepts or to model real world objects and events.
Sample domain model for a health insurance plan In software engineering, a domain model is a conceptual model of the domain that incorporates both behaviour and data.
More generally, we may apply the definition to any open connected domain on which f is analytic, and classify the points of the boundary of the domain as regular or singular: the domain boundary is then a natural boundary if all points are singular, in which case the domain is a domain of holomorphy.
LK domain registry opens IDN name registration facility into Sri Lanka in 2010 and then edulanka launched first LK Domain Registry Announced Their First Registered List Sinhala and Tamil IDN domain names related to education in Sri Lanka. Sinhala IDN domain can be accessible in එඩියුලංකා.ලංකා URL and Tamil IDN domain accessible in எடியுலங்கா.இலங்கை URL.
To facilitate the sharing of services across domains, Tuxedo provides domain gateways. A domain gateway allows importing and exporting services from remote domains. This allows the local domain to see services on remote domains as though they were local services. The domain gateways are responsible for propagating security and transaction context to the remote domain.
The second domain, is α-helical and consists of four α helices linked by long loops. The helices are loosely packed against each other and the entire domain is highly mobile as compared to the large α/β domain. The helical domain is juxtaposed against one end of the cleft in the large domain.
In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.
In molecular biology, the protein domain Adenosine deaminase z-alpha domain refers to an evolutionary conserved protein domain. This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA-editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.
The registration of an emoji domain can be more difficult than with normal domain names using only ASCII characters, since it is sometimes not possible to enter emoji into the online registration forms of domain name registrars, and instead the Punycode representation must be entered. The availability of an emoji domain can be verified by using an emoji domain search engine or by checking the WHOIS data of the punycoded domain.
Sensory epithelial cells and neurons are derived from the proneurosensory domain. This domain can be further sub-categorized into the neurogenic sub-domain and prosensory sub-domain. Prosensory sub- domain eventually gives rise to the support cells and hair cells while the neurogenic sub-domain gives rise to the auditory neuron and vestibular neuron. The middle part of the otic vesicle develops into the ductus and saccus endolymphaticus.
Dinoflagellate luciferase is a multi-domain protein, consisting of an N-terminal domain, and three catalytic domains, each of which preceded by a helical bundle domain. The structure of the dinoflagellate luciferase catalytic domain has been solved. The core part of the domain is a 10 stranded beta barrel that is structurally similar to lipocalins and FABP. The N-terminal domain is conserved between dinoflagellate luciferase and luciferin binding proteins (LBPs).
A reverse DNS lookup is a query of the DNS for domain names when the IP address is known. Multiple domain names may be associated with an IP address. The DNS stores IP addresses in the form of domain names as specially formatted names in pointer (PTR) records within the infrastructure top-level domain arpa. For IPv4, the domain is in-addr.arpa. For IPv6, the reverse lookup domain is ip6.arpa.
These groups can only be used by systems in the same domain. Domain local groups may contain accounts, global groups, and universal groups from any domain, as well as domain local groups from the same domain. Global groups that represent business roles should contain only user or computer accounts. Likewise, domain local groups that describe resource permissions or user rights should contain only global groups that represent business roles.
Like other members of the receptor tyrosine kinase III family, KIT consists of an extracellular domain, a transmembrane domain, a juxtamembrane domain, and an intracellular tyrosine kinase domain. The extracellular domain is composed of five immunoglobulin-like domains, and the protein kinase domain is interrupted by a hydrophilic insert sequence of about 80 amino acids. The ligand stem cell factor binds via the second and third immunoglobulin domains.
The domain name edu is a sponsored top-level domain (sTLD) in the Domain Name System of the Internet. The domain was implemented in 1985 for the purpose of creating a domain name hierarchy for organizations with a focus on education, even for non-U.S.-affiliated entities. Since 2001, new registrants for second- level domain names have been required to be United States–affiliated institutions of higher education.
The SMS.ac website domain name uses the .ac top-level domain for Ascension Island.
One of my domain users was able to unjoin his laptop from the domain.
However, unlike requirements engineering, domain analysis does not solely consist of collection and formalization of information; a creative component exists as well. During the domain analysis process, engineers aim to extend knowledge of the domain beyond what is already known and to categorize the domain into similarities and differences to enhance reconfigurability. Domain analysis primarily produces a domain model, representing the common and varying properties of systems within the domain. The domain model assists with the creation of architectures and components in a configurable manner by acting as a foundation upon which to design these components.
Phase two of The Domain shopping center is anchored by Dillard's. After the Simon Property Group acquired the property that would become The Domain II (Domain Crossing) they bought Endeavor's portion of The Domain I. This second phase, located directly south of The Domain, opened in the spring of 2008.Details firming up for Domain Phase II , Austin American-Statesman, March 2, 2007. Domain Crossing added an additional of retail stores, restaurants, and apartments, as well as a theater - Gold Class Cinema - and other entertainment options.Developer plans minicity for second phase of the Domain in North Austin, Austin American-Statesman, February 24, 2007.
The first catalytic domain of Type R2B RPTPs is considered the active phosphatase domain, whereas the second phosphatase domain is thought to be inactive. Mutations in the second phosphatase domain of PTPrho, however, result in a reduction of phosphatase activity of PTPrho. Deletion of the second tyrosine phosphatase domain in colorectal cancer cells also reduces PTPrho catalytic activity, again demonstrating that the second phosphatase domain of PTPrho does regulate catalytic activity, either directly or indirectly. Catalytic activity of PTPrho may also be regulated by tyrosine phosphorylation of the wedge domain of the first tyrosine phosphatase domain on tyrosine 912 by Fyn tyrosine kinase.
In mathematics, a Bézout domain is a form of a Prüfer domain. It is an integral domain in which the sum of two principal ideals is again a principal ideal. This means that for every pair of elements a Bézout identity holds, and that every finitely generated ideal is principal. Any principal ideal domain (PID) is a Bézout domain, but a Bézout domain need not be a Noetherian ring, so it could have non-finitely generated ideals (which obviously excludes being a PID); if so, it is not a unique factorization domain (UFD), but still is a GCD domain.
In addition, the domain is used for technical name spaces in the management of Internet addressing and other resources. A domain is used for testing internationalized domain names.
NLRPs subfamily contains NLRP1-NLRP14 that are characterized by the presence of PYD domain. IPAF subfamily has two members – IPAF with CARD domain and NAIP with BIR domain.
TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.
In 2005, NIXI/.IN Registry came up with .IN Domain Name Dispute Resolution Policy (INDRP), pertaining to resolution of domain name disputes between the Trademark Holders and the .IN Domain Registrants based upon the similar principles as Uniform Domain Name Dispute Resolution Policy.
Coiled-coil domain containing 94 (CCDC94), is a protein that in humans is encoded by the CCDC94 gene. The CCDC94 protein contains a coiled-coil domain, a domain of unknown function (DUF572), an uncharacterized conserved protein (COG5134), and lacks a transmembrane domain.
The CDC25 homology domain, also called the RasGEF domain, is the catalytic domain of many Ras GEFs, which activate Ras GTPases. The CDC25 domain comprises approximately 500 amino acids and was first identified in the CDC25 protein in budding yeast (Saccharomyces cerevisiae).
The Ku70 and Ku80 proteins consist of three structural domains. The N-terminal domain is an alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six-stranded beta sheet of the Rossmann fold.
300x300px C21orf58 Isoform 1 has three conserved domains: proline-rich domain, histidine rich domain, and DUF4587. Proline-rich domain, Pro175-Pro322, is predicted to mediate protein-protein interactions. Histidine-rich repeat domain, His292-His299, is predicted to facilitate localization. The domain of unknown function, DUF4587 (Arg234\- His291), is a member of pfam15248 exclusively found in eukaryotes.
The MENTAL or MLN64 NH2-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO. The domain is 170 amino acids long. Current data indicates that this domain allows for dimerization between MLN64 and MENTHO molecules and with themselves. The domain may also direct cholesterol transport.
In molecular biology, the YYY domain is a protein domain that is thought to be important in bacterial signal transduction, however the exact function of this protein domain is not known. It is named after the three conserved tyrosines found in the alignment. The domain forms part of the periplasmic sensor domain which binds to unsaturated disaccharides.
A Euclidean domain is an integral domain on which is defined a Euclidean division similar to that of integers. Every Euclidean domain is a principal ideal domain, and thus a UFD. In a Euclidean domain, Euclidean division allows defining a Euclidean algorithm for computing greatest common divisors. However this does not imply the existence of a factorization algorithm.
All DNA polymerases contain three domains. The first domain, which is known as the "fingers domain", interacts with the dNTP and the paired template base. The "fingers domain" also interacts with the template to position it correctly at the active site. Known as the "palm domain", the second domain catalyses the reaction of the transfer of the phosphoryl group.
Domains of EF-TsThe N-terminal domain spans from resides 1-54 (n1-n54), Core domain is from n55-n179, the Dimerization domain is from n180-n228, and lastly the C-terminal domain that is from n264-n282. the core domain contains two subdomains, C and N which interact with domains 3 and 1 of EF-Tu respectively.
Iwakitaira Domain was re-assigned to Naitō Masanaga. Masanaga transferred 20,000 koku domain to his eldest son, Naitō Tadaoki and another 10,000 koku to Hijikata Katsushige creating Izumi Domain and Kubota Domain, leaving Iwakitaira with 70,000 koku. Under early Naitō rule, the domain implemented numerous fiscal reforms, developed large amounts of new rice lands, and constructed massive irrigation works.
However, he only ruled for three years before being transferred to Himeji Domain in Harima Province. Fukushima Domain was re-established in 1686 for Hotta Masanaka, formerly of Yamagata Domain. His son, Hotta Masatora was transferred back to Yamagata in 1700. Fukushima Domain was once again revived in 1702 for Itakura Shigehiro, formerly of Itaki Domain in Shinano Province.
The DNS root domain is unnamed which is expressed by having an empty label in the DNS hierarchy, resulting in a fully qualified domain name ending with the top-level domain. However, in some cases the full stop (period) character is required at the end of the fully qualified domain name. In contrast to a domain name that is fully specified, a domain name that does not include the full path of labels up to the DNS root is often called a partially qualified domain name.
In molecular biology, the HAMP domain (present in Histidine kinases, Adenylate cyclases, Methyl accepting proteins and Phosphatases) is an approximately 50-amino acid alpha-helical region that forms a dimeric, four-helical coiled coil. It is found in bacterial sensor and chemotaxis proteins and in eukaryotic histidine kinases. The bacterial proteins are usually integral membrane proteins and part of a two-component signal transduction pathway. One or several copies of the HAMP domain can be found in association with other domains, such as the histidine kinase domain, the bacterial chemotaxis sensory transducer domain, the PAS repeat, the EAL domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylate cyclase domain, or the response regulatory domain.
VeriSign drops domains in a random order, giving registrars only a vague idea of the particular drop time of a particular domain. Sometimes a group of drop registrars often work in confederation to increase their possibility of registering a dropped domain immediately after it is deleted by the registry. If the domain is caught by a confederation of registrars attempting to fulfill a domain backorder, then whichever domain registrar caught the domain will register it to the entity who backordered the domain. If the newly reregistered domain is captured by a company that has no customers who backordered it, the domain may be auctioned to the highest bidder by the registrar who captured it or an auction intermediary.
Hover was founded in July 2008 by Tucows Inc. after deciding to merge the three domain registration services they already owned, NetIdentity, It's Your Domain (IYD), and Domain Direct.
One could imagine the features indicating important sentences in the news domain might vary considerably from the biomedical domain. However, the unsupervised "recommendation"-based approach applies to any domain.
A Product Domain is the domain in which the to be designed product will be used. This may be an office environment, kitchen environment, a medical domain, and more.
It contains the conserved TLC domain and Hox-like domain common to almost all CerS.
The two frames are multiplexed in the time domain, resulting in Time domain synchronization (TDS).
Domain design takes the domain model produced during the domain analysis phase and aims to produce a generic architecture to which all systems within the domain can conform. In the same way that application engineering uses the functional and non-functional requirements to produce a design, the domain design phase of domain engineering takes the configurable requirements developed during the domain analysis phase and produces a configurable, standardized solution for the family of systems. Domain design aims to produce architectural patterns which solve a problem common across the systems within the domain, despite differing requirement configurations. In addition to the development of patterns during domain design, engineers must also take care to identify the scope of the pattern and the level to which context is relevant to the pattern.
All of the isoforms of CaMKII have: a catalytic domain, an autoinhibitory domain, a variable segment, and a self-association domain. The catalytic domain has several binding sites for ATP and other substrate anchor proteins. It is responsible for the transfer of phosphate from ATP to Ser or Thr residues in substrates. The autoinhibitory domain features a pseudosubstrate site, which binds to the catalytic domain and blocks its ability to phosphorylate proteins.
This 1686-amino acid protein belongs to the ADAMTS family and is one of 19 members known in humans. As an ADAMTS protein, ADAMTS7 contains a shared proteinase domain and an ancillary domain. The proteinase domain can be further divided into a signal peptide, a prodomain, a metalloproteinase domain, and a disintegrin-like domain. In particular, the metalloproteinase domain contains a cysteine-switch motif in its binding site for binding the catalytic zinc ion (Zn2+).
The domain model is a representation of meaningful real-world concepts pertinent to the domain that need to be modeled in software. The concepts include the data involved in the business and rules the business uses in relation to that data. A domain model leverages natural language of the domain. A domain model generally uses the vocabulary of the domain, thus allowing a representation of the model to be communicated to non-technical stakeholders.
Ancien Japon, p. 75 Nishio Yoshitsugu was given the 12,000 koku Haraichi Domain in Musashi Province in 1602. His son, Nishio Tadanaga was transferred to the 20,000 koku Shirai Domain in Kōzuke Province in 1616, and subsequently to Tsuchiura Domain (Hitachi Province) from 1617-1649. The clan then ruled Tanaka Domain (Suruga Province) from 1649-1679, Komoro Domain (Shinano Province) from 1679-1682, and finally settled at Yokosuka Domain (Tōtōmi Province) from 1682-1868.
By default AD assigns all operations master roles to the first DC created in a forest. To provide fault tolerance, there should be multiple domain controllers available within each domain of the Forest. If new domains are created in the forest, the first DC in a new domain holds all of the domain-wide FSMO roles. This is not a satisfactory position if the domain has a large number of domain controllers.
The domain remained in the hands of his descendants until the Meiji restoration. Although administered as a part of Owari Domain, the position of Takasu Domain was somewhat ambiguous, as it was authorized directly by the shogunate rather than by Owari Domain. On the other hand, its daimyō lived permanently in Edo, and administered domain affairs through appointed officials, rather than residing in the domain and was thus not subject to Sankin-kōtai.
Domain analysis produces domain models using methodologies such as domain specific languages, feature tables, facet tables, facet templates, and generic architectures, which describe all of the systems in a domain. Several methodologies for domain analysis have been proposed.Frakes, W.B. and Kyo Kang, (2005), "Software Reuse Research: Status and Future", IEEE Transactions on Software Engineering, 31(7), July, pp. 529-536. The products, or "artifacts", of a domain analysis are sometimes object-oriented models (e.g.
A domain ontology (or domain-specific ontology) represents concepts which belong to a realm of the world, such as biology or politics. Each domain ontology typically models domain-specific definitions of terms. For example, the word card has many different meanings. An ontology about the domain of poker would model the "playing card" meaning of the word, while an ontology about the domain of computer hardware would model the "punched card" and "video card" meanings.
The vector contains all the domain types used to train RFD, and for each domain type the vector also contains a value of 0, 1, or 2. If the protein pair does not contain a certain domain, then the value for that domain is 0. If one of the proteins of the pair contains the domain, then the value is 1. If both proteins contain the domain, then the value is 2.
Although the legal status of domain hijacking was formerly thought to be unclear, certain U.S. federal courts in particular have begun to accept causes of action seeking the return of stolen domain names. Domain hijacking is analogous with theft, in that the original owner is deprived of the benefits of the domain, but theft traditionally relates to concrete goods such as jewelry and electronics, whereas domain name ownership is stored only in the digital state of the domain name registry, a network of computers. For this reason, court actions seeking the recovery of stolen domain names are most frequently filed in the location of the relevant domain registry. In some cases, victims have pursued recovery of stolen domain names through ICANN's (Uniform Domain Name Dispute Resolution Policy (UDRP), but a number of UDRP panels have ruled that the policy is not appropriate for cases involving domain theft.
CesA1 adds ketoisocaproic acid to the adenylation domain. The thiolation domain will then move the ketoisocaproic acid along the ketoreductase domain, which reduces ketoisocaproic acid into D-α-hydroxyisocaproic acid with the cofactor NADPH. In module CesA2, L-alanine is added to the adenylation domain.
The homologous domain in FAM98A is the DUF2465 (Domain of Unknown Function 2465) domain. The function of this domain, like the gene itself, is largely unknown, though it has been reported that it preferentially binds to RNA, targeting mRNA in FAM98A and tRNA in FAM98B.
With the start of the Boshin War, the domain initially attempted to remain neutral, but bowed to pressure from Sendai Domain and joined the Ōuetsu Reppan Dōmei.Hoshi, Ōuetsu Reppan Dōmei, pp. 88–89. Morioka forces attacked the pro-Imperial Tsugaru Domain and Akita Domain.
Domain propagation memory is also called bubble memory. The basic idea is to control domain wall motion in a magnetic medium that is free of microstructure. Bubble refers to a stable cylindrical domain. Data is then recorded by the presence/absence of a bubble domain.
The actin monomer has two asymmetric domains; the larger inner domain comprised by sub-domains 3 and 4, and the smaller outer domain by sub-domains 1 and 2. Both the amino and carboxy- termini lie in sub-domain 1 of the outer domain.
In mathematics, the Fictitious domain method is a method to find the solution of a partial differential equations on a complicated domain D, by substituting a given problem posed on a domain D, with a new problem posed on a simple domain \Omega containing D.
Being an accredited registrar allows Vodien to partner and work directly with various global domain name registries to provide domain name registrations of domain names such as .aero, .asia, .biz, .
The domain name OOO (Triple O - Alphabet O) is a top-level domain (TLD) in the Domain Name System of the Internet. It was launched and is operated by Infibeam.
Domain servers in listed order: NS.UU.NET 137.39.1.3 UUCP-GW-1.PA.DEC.COM 16.1.0.18 Top Level domain for Argentine Republic For information concerning this domain, please consult the Administrative Contact listed above.
Keyword Search Search the database using a superfamily, family, or species name plus a sequence, SCOP, PDB, or HMM ID's. A successful search yields the class, folds, superfamilies, families, and individual proteins matching the query. Domain Assignments The database has domain assignments, alignments, and architectures for completely sequence eukaryotic and prokaryotic organisms, plus sequence collections. Comparative Genomics Tools Browse unusual (over- and under-represented) superfamilies and families, adjacent domain pair lists and graphs, unique domain pairs, domain combinations, domain architecture co-occurrence networks, and domain distribution across taxonomic kingdoms for each organism.
One gene, termed topo VI-B (since it resembles gyrB), contains the ATPase domain, a transducer domain (), and a C-terminal Ig-fold-like H2TH domain (). The second gene, termed topo VI-A (), contains the WHD and the Toprim domain. The ATPase domain of topo VI B was solved in multiple nucleotide states.Corbett and Berger, EMBO J 2003 It closely resembles that of the GHKL domain of topo II and MutL and shows that the nucleotide state (ADP versus ATP) effects the orientation of the transducer domain ( and 1MX0).
The Deva domain (also known as the God domain or Blissful State) is the domain of bliss. The disadvantage of this domain is that things are so very comfortable there, that these beings completely neglect to work towards enlightenment. Instead they gradually use up the good karma they had previously accumulated, and so they subsequently fall to a lower rebirth. The Deva domain is sometimes also referred to as the gods' domain, because its inhabitants are so powerful within their own domain, that compared to humans, they resemble the gods of Greek or Roman mythology.
In DSP, engineers usually study digital signals in one of the following domains: time domain (one-dimensional signals), spatial domain (multidimensional signals), frequency domain, and wavelet domains. They choose the domain in which to process a signal by making an informed assumption (or by trying different possibilities) as to which domain best represents the essential characteristics of the signal and the processing to be applied to it. A sequence of samples from a measuring device produces a temporal or spatial domain representation, whereas a discrete Fourier transform produces the frequency domain representation.
Microsoft's implementation of RBAC leverages the different security group scopes featured in Active Directory: ; Global security groups : Domain security groups with global scope represent business roles or job functions within the domain. These groups may contain accounts and other global groups from the same domain, and they can be used by resources in any domain in the forest. They can be changed frequently without causing global catalog replication. ; Domain local security groups : Domain security groups with domain local scope describe the low-level permissions or user rights to which they are assigned.
A country code second-level domain is a second-level domain to a country code top-level domain. Such a domain may be reserved by a domain name registry for the registration of third-level domains, or assigned to a third party as a subdomain. Many country code domain registries implement domain name classes at the second level underneath their ccTLD, such as are present in the original generic top-level domains , , and , which were intended for commercial entities, network operators, and non-profit organizations, respectively. Many countries implement additional classes.
Domain registration information is maintained by the domain name registries, which contract with domain registrars to provide registration services to the public. An end user selects a registrar to provide the registration service, and that registrar becomes the designated registrar for the domain chosen by the user. Only the designated registrar may modify or delete information about domain names in a central registry database. It is not unusual for an end user to switch registrars, invoking a domain transfer process between the registrars involved, that is governed by specific domain name transfer policies.
The LRRK2 gene encodes a protein with an armadillo repeats (ARM) region, an ankyrin repeat (ANK) region, a leucine-rich repeat (LRR) domain, a kinase domain, a RAS domain, a GTPase domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons.
An emoji domain is a domain name with emoji in it, for example `www.😉.tld`.
Retrieved 2008-03-09. shows that domain names are extremely vulnerable to censorship. Some domain registrars have suspended customers' domain names even in the absence of a court order. For the affected customer, blocking of a domain name is a far bigger problem than a registrar refusing to provide a service; typically, the registrar keeps full control of the domain names in question.
Proteins with the DM domain are found in many model organisms. Many C. elegans Mab proteins contain this domain, the best-known one being mab-3. Human proteins containing this domain include DMRT1, DMRT2, DMRT3, DMRTA1, DMRTA2, DMRTB1, and DMRTC2; each of these have a mouse homolog. DMRT1 homologs have an additional common domain C-terminal to the DM domain.
A discrete frequency domain is a frequency domain that is discrete rather than continuous. For example, the discrete Fourier transform maps a function having a discrete time domain into one having a discrete frequency domain. The discrete-time Fourier transform, on the other hand, maps functions with discrete time (discrete-time signals) to functions that have a continuous frequency domain.
The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain.
The structure of KAT5 includes an acetyl CoA binding domain and a zinc finger in the MYST domain, and a CHROMO domain. Excess acetyl CoA is necessary for acetylation of histones. The zinc finger domain has been shown to aid in the acetylation process as well. The CHROMO domain aids in KAT5 ability to bind chromatin, which is important for DNA repair.
Octanoyltransferases and lipoyl- amidotransferases are single domain enzymes. Characterized lipoate protein ligases require an additional accessory domain () to adenylate the acyl substrate. Biotin protein ligases have an additional C-terminal domain which participates in biotin adenylation and dimerization. Biotin protein ligases may also have an additional N-terminal domain required for DNA binding, although this domain is not always present.
The domain aftermarket is the secondary market for Internet domain names in which a party interested in acquiring a domain that is already registered bids or negotiates a price to effect the transfer of registration from the registered holder of that domain name. The professional pursuit of speculation in the domain aftermarket is known as domaining. The domain aftermarket has grown substantially, as an increasing number of generic domains names that promise 'marketing appeal' and 'desirability' are registered by domain warehouses, or resellers. The domain aftermarket is facilitated by auction houses which provide communication methods for buyers and sellers to interact, often anonymously, to negotiate and close a transaction.
Domain name auction A domain name auction facilitates the buying and selling of currently registered domain names, enabling individuals to purchase a previously registered domain that suits their needs from an owner wishing to sell. A Drop registrar offers sales of expiring domains; but with a domain auction there is no need to wait until (and if) a current owner allows the registration to lapse before purchasing the domain you most want to own. Domain auction sites allow users to search multiple domain names that are listed for sale by owner, and to place bids on the names they want to purchase. As in any auction, the highest bidder wins.
All RBPs can bind to RNA depends on different specificities and affinities. RBPs contain at least one RNA-binding domains and usually they have multiple binding domains. RNA-binding domain (RBD, also known as RNP domain and RNA recognition motif, RRM), K-homology (KH) domain (type I and type II), RGG (Arg-Gly-Gly) box, Sm domain; DEAD/DEAH box, zinc finger (ZnF, mostly C-x8-X-x5-X-x3-H), double stranded RNA-binding domain (dsRBD), cold- shock domain; Pumilio/FBF (PUF or Pum-HD) domain, and the Piwi/Argonaute/Zwille (PAZ) domain have been well characterized. RBPs are constructed by multiple binding domains.
In molecular biology, the catalase-related immune-responsive domain is a protein domain found in catalases. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells.
The domain name pro is a generic top-level domain in the Domain Name System of the Internet. Its name is derived from professional, indicating its intended use by certified professionals.
An .at-Domain can be between one and 63 characters long. Registrations of internationalized domain names are accepted. In 2007, it was made possible to register domain names containing only numbers.
The longer N-terminal domain is likely an enzymatic domain, and the shorter C-terminal domain is likely a means of safely transporting the very reactive selenium atom throughout the body.
The target domain is described using target domain deliverables. There are two different types of target domain deliverables: operational items and descriptive items. Both will be discussed in the following paragraphs.
A rect function turns into a sinc function as the order of the fractional Fourier transform becomes 1 The usual interpretation of the Fourier transform is as a transformation of a time domain signal into a frequency domain signal. On the other hand, the interpretation of the inverse Fourier transform is as a transformation of a frequency domain signal into a time domain signal. Apparently, fractional Fourier transforms can transform a signal (either in the time domain or frequency domain) into the domain between time and frequency: it is a rotation in the time-frequency domain. This perspective is generalized by the linear canonical transformation, which generalizes the fractional Fourier transform and allows linear transforms of the time- frequency domain other than rotation.
A domain name registry is a database of all domain names and the associated registrant information in the top level domains of the Domain Name System (DNS) of the Internet that enables third party entities to request administrative control of a domain name. Most registries operate on the top- level and second-level of the DNS. A registry operator, sometimes called a network information center (NIC), maintains all administrative data of the domain and generates a zone file which contains the addresses of the nameservers for each domain. Each registry is an organization that manages the registration of domain names within the domains for which it is responsible, controls the policies of domain name allocation, and technically operates its domain.
The domain name .mobi is a generic top-level domain (gTLD) in the Domain Name System (DNS) of the Internet. Its name is derived from the adjective mobile. The domain was approved by ICANN on 11 July 2005, and is managed by the mTLD global registry.
Myogenic determination factor 5 proteins contain three conserved protein domains. A C-terminal Myf5 domain, a central basic helix-loop-helix (bHLH) domain and an N-terminal basic domain. The bHLH region mediates specific DNA binding. With 12 residues of the basic domain involved in DNA binding.
NBEAL1 has one WD40 domain within NBEAL1. From amino acid 2409 to 2682 is the entire WD40 domain. Within the domain, from 2406 to 2439, there is a structural motif WD40 repeat. The WD40 domain is found in a number of eukaryotic proteins that have multiple functions.
Ankyrins contain four functional domains: an N-terminal domain that contains 24 tandem ankyrin repeats, a central domain that binds to spectrin, a death domain that binds to proteins involved in apoptosis, and a C-terminal regulatory domain that is highly variable between different ankyrin proteins.
In particular, in a Bézout domain, irreducibles are prime (but as the algebraic integer example shows, they need not exist). For a Bézout domain R, the following conditions are all equivalent: # R is a principal ideal domain. # R is Noetherian. # R is a unique factorization domain (UFD).
' was a Japanese domain of the Edo period, located in Musashi Province (modern-day Kisai, Saitama). The domain existed until 1632, when the last lord, Ōkubo Tadamoto, was moved to the Kanō Domain, and the Kisai holdings were then merged into the territory of the Kawagoe Domain.
Early in thalamic development two progenitor domains form, a caudal domain, and a rostral domain. The caudal domain gives rise to all of the glutamatergic neurons in the adult thalamus while the rostral domain gives rise to all of the GABAergic neurons in the adult thalamus.
The solution structure of the first KH domain of FMR1 and of the C-terminal KH domain of hnRNP K determined by nuclear magnetic resonance (NMR) revealed a beta-alpha-alpha-beta-beta- alpha structure. Autoantibodies to NOVA1, a KH domain protein, cause paraneoplastic opsoclonus ataxia. The KH domain is found at the N-terminus of the ribosomal protein S3. This domain is unusual in that it has a different fold compared to the normal KH domain.
N-terminal domain (red), MD = middle domain (green), CTD = C-terminal domain (blue). Crystallographic structure of the ATP binding pocket of Hsp90 where ATP is represented by a ball and stick figure (carbon atoms = grey, nitrogen = blue, oxygen = red, phosphorus = orange) and Hsp90 is depicted as a solid surface (negatively charged = red, positively charged = blue, electrostatically neutral = grey). Pincer movement of Hsp90 coupled to the ATPase cycle. NTD = N-terminal domain, MD = middle domain, CTD = C-terminal domain.
He greatly improved the finances of the domain by sponsoring horse breeding as a local industry. He also achieved an elevation in the status of the domain from a tozama domain to a fudai domain. His wife was a daughter of Sakai Tadanao of Obama Domain. However, the death of his son and heir Norisue in 1715 greatly disturbed him, and he withdraw from all of the affairs of the domain, turning power over to a retainer, Araki Takamura.
The C-terminal HIN domain binds double stranded DNA (either viral, bacterial, or even host) and acts as a cytosolic dsDNA sensor. This leads to the oligomerization of the inflammasome complex. The N-terminal pyrin domain of AIM2 interacts with the pyrin domain of another protein ASC (or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain). ASC also contains a CARD domain (caspase activation and recruitment domain), that recruits procaspase-1 to the complex.
In molecular biology, the ARID domain (AT-rich interaction domain; also known as BRIGHT (B-cell Regulator of Ig Heavy chain Transcription) domain)) is a protein domain that binds to DNA. ARID domain-containing proteins are found in fungi, plants Zheng B, He H, Zheng Y, Wu W, McCormick S (2014) An ARID Domain- Containing Protein within Nuclear Bodies Is Required for Sperm Cell Formation in Arabidopsis thaliana. PLoS Genet 10(7): e1004421. doi: 10.1371/journal.pgen.
Gomez-Ramirez 2015 Thus a Dedekind domain is a domain that either is a field, or satisfies any one, and hence all five, of (DD1) through (DD5). Which of these conditions one takes as the definition is therefore merely a matter of taste. In practice, it is often easiest to verify (DD4). A Krull domain is a higher-dimensional analog of a Dedekind domain: a Dedekind domain that is not a field is a Krull domain of dimension 1.
The domain name gov is a sponsored top-level domain (sTLD) in the Domain Name System of the Internet. The name is derived from the word government, indicating its restricted use by government entities. The gov domain is administered by the General Services Administration (GSA), an independent agency of the United States federal government. The U.S. is the only country that has a government-specific top-level domain in addition to its country- code top-level domain.
The domain as then given to Abe Masakuni, formerly of Miyazu Domain in Tango, who ruled for 13 years until his transfer to Fukuyama Domain as well. The domain was reduced further to 70,000 koku and was then given to Toda Tadazane, formerly of Takada Domain in Echigo. He served as rōjū to Tokugawa Ietsugu and Tokugawa Yoshimune. His son and grandson ruled, until the clan traded places with Matsudaira Tadamasa of Shimabara Domain in Hizen in 1738.
It turns out that a left and right fir is a domain. Furthermore, a commutative fir is precisely a principal ideal domain, while a commutative semifir is precisely a Bézout domain. These last facts are not generally true for noncommutative rings, however . Every principal right ideal domain R is a right fir, since every nonzero principal right ideal of a domain is isomorphic to R. In the same way, a right Bézout domain is a semifir.
Hasunoike Domain was originally a sub- domain of the Saga Domain, founded for Nabeshima Naozumi, the fifth son of the first daimyō of Saga Domain, Nabeshima Katsushige. Naozumi was assigned holdings of 52,000 koku. The headquarters of the domain were within the san- no-maru (third bailey) of Saga Castle; later a separate structure, a jin'ya in the Hasunoike district of Saga city was erected. Hasunoike initially had sankin-kōtai and was treated as if an independent domain.
Both coronavirus (CoV) and Toroviruses (ToV) HE monomers are made up of the same three domains which are: central esterase/hydrolase domain, receptor binding lectin domain, and membrane proximal domain which is small. The two monomers of HE dimer in both CoV and ToV involve the same two contact regions (CR 1and 2). CR 1 contain the receptor binding domain and Contact region 2 that contain membrane proximal domain. Yet, ToV HE contacts region 2 contain additional esterase domain.
The A1 domain activates and loads threonine, an amino acid, onto T1, followed by a C1 promoted condensation of 3-aminosalicylate and threonine. The A2 domain activates and loads pyruvate onto T2. Pyruvate is reduced by the KR domain and condensed with threonine by C2 6\. The Ketosynthase domain of PKS catalyses the decarboxylative condensation between the aminoacyl thioester attached to AntC T2 domain and the 2-carboxy-acyl moiety attached to AntD Acetyl Carrier Protein domain. 7\.
Located adjacent to the B domain, the R domain is involved in suppressing Elk1 transcriptional activity. This domain harbors the lysine residues that are likely to undergo SUMOylation, a post-translational event that strengthens the inhibition function of the R domain. The D domain plays the key role of binding to active Mitogen-activated protein kinases (MAPKs). Located in the C-terminal region of Elk1, the C domain includes the amino acids that actually become phosphorylated by MAPKs.
Registration of a domain name establishes a set of name server records in the DNS servers of the parent domain, indicating the IP addresses of DNS servers that are authoritative for the domain. This provides a reference for direct queries of domain data. Registration of a domain does not automatically imply the provision of DNS services for the registered domain. Most registrars do offer DNS hosting as an optional free service for domains registered through them.
The catalytic region can be subdivided into three domains: an N-domain (N-terminal), a large L-domain, and a small S-domain (inserted within the L-domain). The L-domain binds the substrate, while the S-domain binds NADP. Class II HMG-CoA reductases catalyse the reverse reaction of class I enzymes, namely the NAD-dependent synthesis of HMG-CoA from mevalonate and CoA. Some bacteria, such as Pseudomonas mevalonii, can use mevalonate as the sole carbon source.
Standalone DFS allows for only DFS roots on the local computer, and thus does not use Active Directory. Domain-based DFS roots exist within Active Directory and can have their information distributed to other domain controllers within the domain – this provides fault tolerance to DFS. DFS roots that exist on a domain must be hosted on a domain controller or on a domain member server. The file and root information is replicated via the Microsoft File Replication Service (FRS).
Tudor domain-containing protein 3 is a protein that in humans is encoded by the TDRD3 gene. It contains a Tudor domain and UBA protein domain and has three distinct Protein isoforms.
In October 2019, the official Twitter page announced that the site returned to the .se domain. In February 2020, it was announced that the site changed its domain to the .wiki domain.
Schematic of the PRDM9 Domain Architecture in mice PRDM9 has multiple domains including KRAB domain, SSXRD, PR/SET domain (H3K4 & H3K36 trimethyltransferase), and an array of C2H2 Zinc Finger domains (DNA binding).
Smallest domain on the enzyme, which is attached to the PLP- binding domain by a long, kinked α-helix. The domain is structured into four- stranded antiparallel β-sheet with neighboring helices.
An integral domain is called a Prüfer domain if every torsion-free module over it is flat.
Domain of the Cube Forum."5x5 can be solved in 109 MTM". Domain of the Cube Forum.
This article incorporates public domain text (a public domain work of the United States Government) from references.
This article incorporates public domain text (a public domain work of the United States Government) from reference.
The N-terminal domain of INCENP is the domain involved in formation of this three-helical bundle.
For example, ' explicitly specifies an absolute domain name that ends with the empty top level domain label.
VistA Imaging uses proprietary modules not in the public domain. This makes its public domain use limited.
CCDC120 has 3 identifiable paralogs in humans, FERM Domain Containing 4A, FERM domain Containing 4B, and C1orf106.
In a number of countries, .co (an abbreviation of commercial) is used as a second-level domain in the Domain Name System used to route internet traffic. Domain registrants register second-level domains of the form .co. xx, where xx is the country code top level domain (e.g.
CAP-like 'Pathogenesis-related 1' domain (PR-1) in white. ShK-like 'Cysteine-Rich Domain' (CRD) in red. Disulphides in yellow. () More distantly related are Cysteine-rich secretory proteins (CRISPs), which contain a ShK-like 'Cystine-rich domain' as well as a larger CAP-like 'Pathogenesis related 1' domain.
The helical insertion domain is inserted into the GTP- binding domain before switch region I and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation.
The domain was installed in the Domain Name System on 5 May 2010.First IDN ccTLDs available, ICANN announcement, 2010-05-05 The first second-level sub domain is عربي.امارات which is transliterated as arabi.emarat. The United Arab Emirates is also assigned the country code top-level domain .ae.
A domain model is a system of abstractions that describes selected aspects of a sphere of knowledge, influence or activity (a domainEvans, Eric Domain-Driven Design: Definitions and Pattern Summaries. Domain Language Inc., 2006, p. 3.). The model can then be used to solve problems related to that domain.
The domain name .travel is a top-level domain in the Domain Name System of the Internet. .travel domain names are available to individuals and / or organizations who provides or plans to provide services, products or content in or to the travel industry. It is sponsored by Donuts Inc.
The domain name home.arpa was reserved by the Internet Engineering task force in May 2018 as a special-use domain name for non-unique DNS services in residential networking, to avoid the use of the top-level domain home., which would require DNSSEC signatures.RFC 8375, Special-Use Domain home.
Group II IEPs share a related conserved domain, known as either "Domain X" in organelles or "GIIM" in bacteria, that is not found in other retroelements. Domain X is essential for splicing in yeast mitochrondria. This domain may be responsible for recognizing and binding to intron RNA or DNA.
The SPRY domain is required for substrate recruitment. The NMR chemical shifts for backbone of the PRYSPRY domain of TRIM25 is assigned based on triple-resonance experiments using uniformly isotopic labeled protein and the secondary structure of the domain PRYSPRY domain of TRIM25 predicted based on the NMR assignments.
Pyrin is composed of a PYD domain, two B-boxes, a coiled-coil domain as well as a B30.2 domain at its C-terminus, whereby the latter is only present in human pyrin.
DNSimple is a managed domain name server service operated by Aetrion LLC d/b/a DNSimple, which offers DNS hosting, domain registration, and SSL certificates. DNSimple is also an ICANN-accredited domain registrar.
This domain is situated at the base of the catalytic domain, however its function remains unknown. The central domain is the catalytic domain, which binds a phosphate ion that is proximal the highly conserved Glu. The arrangement of the phosphate and the glutamate is thought to cause nucleophilic attack on the anomeric carbon atom. The catalytic domain also forms the majority of the dimerisation interface.
Domain tasting is the practice of temporarily registering a domain under the five-day Add Grace Period at the beginning of the registration of an ICANN- regulated second-level domain. During this period, a registration must be fully refunded by the domain name registry if cancelled. This was designed to address accidental registrations, but domain tasters use the Add Grace Period for illegal purposes.
Calcium-activated potassium channel subunit beta-2 comprises two domains. An N-terminal cytoplasmic domain, the ball and chain domain, which is responsible for the fast inactivation of these channels, and a C-terminal calcium-activated potassium channel beta subunit domain. The N-terminal domain only occurs in calcium-activated potassium channel subunit beta-2, while the C-terminal domain is found in related proteins.
Originally a sub-domain of the Owari Domain, which was ruled by the Tokugawa clan's Owari branch, the Inuyama Domain gained independence when it was recognized in 1868. Just three years after the Inuyama Domain was officially recognized, the domain system was abolished and the area became Inuyama Prefecture. Three months after that, it was merged into Nagoya Prefecture, which eventually became modern-day Aichi Prefecture.
The Fibronectin type III domain is an evolutionary conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 amino acids long and possesses a beta sandwich structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present.
The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif. The phosphotyrosine-binding domain of insulin receptor substrate-1 is not related to the phosphotyrosine-binding domain of tensin. Insulin receptor substrate-1 proteins contain both a pleckstrin homology domain and a phosphotyrosine binding (PTB) domain. The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor.
Namespaces allows users to own domain names on the NEM blockchain just like a person or an organization owns an Internet domain name. Just like on the internet, a domain can have a sub-domain, namespaces can have sub-namespaces. And it is possible to create multiple sub-namespaces with the same name (example: “foo.bar” and “foo2.bar”, “bar” is the sub-namespace/sub- domain).
Osteonectin is a 40 kD acidic and cysteine-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) a Ca++ binding domain near the glutamic acid-rich region at the amino terminus (domain I), 2) a cysteine-rich domain (II), 3) a hydrophilic region (domain III), and 4) an EF hand motif at the carboxy terminus region (domain IV).
CerS contain a unique C-terminal domain called the TLC domain and both mammalian and yeast CerS have 5–8 transmembrane domains. All mammalian CerS, aside from CerS1, contain a Hox-like domain shared by transcription factors important in development, although the first 15 amino acids of this domain are missing in CerS, indicating that this domain likely does not function as a genuine transcription factor.
The definitive descriptions of the rules for forming domain names appear in RFC 1035, RFC 1123, RFC 2181, and RFC 5892. A domain name consists of one or more parts, technically called labels, that are conventionally concatenated, and delimited by dots, such as example.com. The right-most label conveys the top-level domain; for example, the domain name www.example.com belongs to the top-level domain com.
In mathematics, a Goldman domain or G-domain is an integral domain A whose field of fractions is a finitely generated algebra over A.Goldman domains/ideals are called G-domains/ideals in (Kaplansky 1974). They are named after Oscar Goldman. An overring (i.e., an intermediate ring lying between the ring and its field of fractions) of a Goldman domain is again a Goldman domain.
Mutations in DLG1 are associated to Crohn's Disease. three PDZ domains, an SH3 domain, hook domain, I3 domain, and finally an inactive guanylate kinase (GK) domain. Each of these domains has specific interacting partners that help define SAP97's unique function. The n-terminal of SAP97 can be alternatively spliced to contain a double-cysteine/palmitoylation site (α-isoform), or an L27 domain (β-isoform.
Following the establishment of the Tokugawa shogunate, Fukushima was the centre of a tenryō territory with a kokudaka of 200,000 koku. In 1679, Honda Tadakuni was transferred from Yamato-Koriyama Domain, marking the start of Fukushima Domain. However, he only ruled for three years before being transferred to Himeji Domain. Fukushima Domain was re-established in 1686 for Hotta Masanaka, formerly of Yamagata Domain.
Backprojection Algorithm has two methods: Time-domain Backprojection and Frequency-domain Backprojection. The time-domain Backprojection has more advantages over frequency-domain and thus, is more preferred. The time-domain Backprojection forms images or spectrums by matching the data acquired from the radar and as per what it expects to receive. It can be considered as an ideal matched-filter for synthetic-aperture radar.
Mont-Saint-Grégoire (Maple/bitternut hickory domain) The deciduous forest sub-zone contains northern hardwood forests and is dominated by maples (Acer). Windthrow is an important element of the forest dynamics. It includes the maple / bitternut hickory domain, the maple / basswood domain and the maple / yellow birch domain. The maple / bitternut hickory domain has the mildest climate in Quebec and has very diverse forests.
The Hori clan survived through a cadet line at Muramatsu Domain. The domain then went through a number of changes in control during a brief period. Honda Tadayoshi was transferred from Kakegawa Domain in 1644 and transferred to Shirakawa Domain in 1649. Matsudaira Naoyori from Himeji Domain arrived in 1649 and ruled to 1667 when we was returned to Himeji after widespread revolts over taxation.
The catalytic region, which is responsible for the activation of Rap, consists of a CDC25 homology domain (CDC25-HD), a Ras exchange motif (REM) domain, and a Ras association (RA) domain. Epac2B is devoid of the first cNBD-A domain and Epac2C is devoid of a cNBD-A and a DEP domain. Epac2B and Epac2C are expressed specifically in adrenal gland and liver, respectively.
The two ATPase domains are connected by a short polypeptide linker. A domain preceding the D1 domain (N-terminal domain) and a short carboxyl-terminal tail are involved in interaction with cofactors. The N-domain is connected to the D1 domain by a short N-D1 linker. Most known substrates of p97/CDC48 are modified with ubiquitin chains and degraded by the 26S proteasome.
A formal language for higher-order predicate logic looks much the same as a formal language for first-order logic. The difference is that there are now many different types of variables. Some variables correspond to elements of the domain, as in first-order logic. Other variables correspond to objects of higher type: subsets of the domain, functions from the domain, functions that take a subset of the domain and return a function from the domain to subsets of the domain, etc.
GoDaddy has a lot of tools to provide various services to its customers. With GoDaddy Auctions, which is GoDaddy's own domain marketplace, users can list their domain names for sale or bid on other domain name auctions. GoDaddy also lists expiring domain name auctions from other registrars, so thousands of valuable expiring domain names go up for auction and selling every day on GoDaddy Auctions. These expiring domain names go directly to the new owner’s GoDaddy account before they expire.
Komoro was part of the holdings of Kōfu Domain from 1622-1624, but was revived as an independent domain for Matsudaira Norinaga from 1624-1647. On his death without an heir, the domain was placed under Matsumoto Domain for a year, until the transfer of Aoyama Munetoshi, who was raised from hatamoto status. He subsequently served as Osaka jōdai from 1662, and Komoro was given to Sakai Tadayoshi, formerly of Isesaki Domain. Sakai was demoted to Tanaka Domain in Suruga Province in 1679.
Domain names are formed by the rules and procedures of the Domain Name System (DNS). Any name registered in the DNS is a domain name. Domain names are organized in subordinate levels (subdomains) of the DNS root domain, which is nameless. The first-level set of domain names are the top-level domains (TLDs), including the generic top-level domains (gTLDs), such as the prominent domains com, info, net, edu, and org, and the country code top-level domains (ccTLDs).
V1 isoforms has the GAG-β domain, V2 has the GAG-α domain, V3 is void of any GAG attachment domains and V4 has a portion of the GAG-β domain. The GAGs, being composed of repeating disaccharide units, contribute to the negative charge and many other properties of proteoglycans. The C-terminal (G3) globular domain consists of one or two Epidermal growth factor (EGF) repeats, a C-type lectin domain and complement regulatory protein (CRP)-like domain. The C-terminal domain binds a variety of ligands in ECM which contribute significantly to the functions of lecticans.
Syntaxin consists of a transmembrane domain (TMD), alpha-helical SNARE domain, a short linker region, and the Habc domain which consists of three alpha-helical regions. The SNARE domain in syntaxin serves as a target site for docking of SNAP-25 and synaptobrevin in order to form the four helix bundle requisite to the SNARE complex and subsequent fusion. The Habc domain, however, serves as an autoinhibitory domain in syntaxin. It has been shown to fold over and associate with the SNARE domain of syntaxin inducing a "closed" state, creating a physical barrier to the formation of the SNARE motif.
A network domain is an administrative grouping of multiple private computer networks or hosts within the same infrastructure. Compare: Compare: Domains can be identified using a domain name; domains which need to be accessible from the public Internet can be assigned a globally unique name within the Domain Name System (DNS). A domain controller is a server that automates the logins, user groups, and architecture of a domain, rather than manually coding this information on each host in the domain. It is common practice, but not required, to have the domain controller act as a DNS server.
A wait-listing service (WLS) provided by a domain name registry provides the ability to option a domain name that is already registered. The option-holder then has the ability to have first rights to that domain name if the current registrant should cancel their registration. Taking such an option is no guarantee a person will be able to register the domain name, merely that the person will be able to if the domain name becomes otherwise available. If the existing holder continues to renew their domain name, the option-holder will never get the domain through the procedure.
A Bloch wall is a narrow transition region at the boundary between magnetic domains, over which the magnetization changes from its value in one domain to that in the next, named after the physicist Felix Bloch. In a Bloch domain wall, the magnetization rotates about the normal of the domain wall (in other words, the magnetization always points along the domain wall plane in a 3D system), in contrast to Néel domain walls. Bloch domain walls appear in bulk materials, i.e. when sizes of magnetic material are considerably larger than domain wall width (according to the width definition of Lilley ).
An emf in the electrical domain is analogous to an mmf in the magnetic domain, and a transducer doing such a conversion would be represented as a transformer. However, real electro-magnetic transducers usually behave as gyrators. A transducer from the magnetic domain to the electrical domain will obey Faraday's law of induction, that is, a rate of change of magnetic flux (a magnetic current in this analogy) produces a proportional emf in the electrical domain. Similarly, a transducer from the electrical domain to the magnetic domain will obey Ampère's circuital law, that is, an electric current will produce a mmf.
The misato protein contains an N-terminal misato segment II myosin-like domain and a central tubulin domain.
However, the origin of eukaryotes remains unresolved, and the two domain and three domain scenarios remain viable hypotheses.
There is a domain, DUF4596, present from 1311 - 1354 in KIAA1107. The function of this domain is unknown.
Hematopoietic SH2 Domain Containing (HSH2D) protein is a protein encoded by the hematopoietic SH2 domain containing (HSH2D) gene.
X-ray crystal structures have been obtained for several GRKs (GRK1, GRK2, GRK4, GRK5 and GRK6), alone or bound to ligands. Overall, GRKs share sequence homology and domain organization in which the central protein kinase catalytic domain is preceded by a domain with homology to the active domain of Regulator of G protein Signaling proteins, RGS proteins (the RGS-homology – RH – domain) and is followed by a variable carboxyl terminal tail regulatory region. In the folded proteins, the kinase domain forms a typical bi-lobe kinase structure with a central ATP-binding active site. The RH domain is composed of alpha-helical region formed from the amino terminal sequence plus a short stretch of sequence following the kinase domain that provides 2 additional helices, and makes extensive contacts with one side of the kinase domain.
With Windows NT 4 Server, one domain controller per domain was configured as the primary domain controller (PDC); all other domain controllers were backup domain controllers (BDC). Because of the critical nature of the PDC, best practices dictated that the PDC should be dedicated solely to domain services, and not used for file, print or application services that could slow down or crash the system. Some network administrators took the additional step of having a dedicated BDC online for the express purpose of being available for promotion if the PDC failed. A BDC could authenticate the users in a domain, but all updates to the domain (new users, changed passwords, group membership, etc.) could only be made via the PDC, which would then propagate these changes to all BDCs in the domain.
The registry accepts registrations of internationalized domain names. .ac is marketed by some domain-brokers as a domain for the city of Aachen, Germany, after the automotive license plate designation ("AC") for the city.
The domain maintained its primary residence (kamiyashiki) in Edo at Daimyō-kōji, in Marunouchi.Edo daimyo.net In 1767, Yamagata Domain was assigned to the Akimoto clan, formerly of Kawagoe Domain, who ruled for four generations until 1845. During the Bakumatsu period, the domain was assigned to its final rulers, the Mizuno clan.
The latter concluded that the .au domain space should be as open as possible, with competition at both the domain name registry and the domain name registrar levels. The Name Policy Advisory Panel resulted in naming policy remaining mostly unchanged, with the exception of the .id.au sub-domain which was liberalised.
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1), or DCC-interacting protein 13-alpha (DIP13alpha), is a protein that in humans is encoded by the APPL1 gene. APPL1 contains several key interactory domains: pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain and Bin–Amphiphysin–Rvs (BAR) domain.
Proteins in this family consist of three domains. The N-terminal domain is the J domain (described above). The central domain is a cysteine-rich region, which contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion.
SOGA2 contains Domain of Unknown Function 4201 (DUF4201) from aa 16-235. This domain is specific to the Coiled Coil Domain Containing family of proteins in eukaryotes. It also contains two copies of Domain of Unknown Function 3166 (DUF3166): one from aa 140-235 and one from aa 269-364.
DENIC eG is the manager of the .de domain, the country-code top-level domain for Germany. It was founded in 1996 and is organised as a non-regulated not- for-profit cooperative. DENIC provides the Domain Name Service Domain Name System (DNS) as well as registration and management services for .
The second domain is a glutamine-rich domain which comprises a majority of the protein and is highly conserved among orthologs. The final domain is a Domain of unknown function (DUF3504) found near the end of the protein sequence. All three of these domains are well conserved throughout strict orthologs.
A domain validated certificate (DV) is an X.509 digital certificate typically used for Transport Layer Security (TLS) where the domain name of the applicant is validated by proving some control over a DNS domain. Domain validated certificates were first distributed by GeoTrust in 2002 before becoming a widely accepted method.
In the theory of harmonic functions, Bôcher's theorem states that a positive harmonic function in a punctured domain (an open domain minus one point in the interior) is a linear combination of a harmonic function in the unpunctured domain with a scaled fundamental solution for the Laplacian in that domain.
All three contain the Dbl oncogene homology (DH) domain plus Pleckstrin homology (PH) domain (DH/PH domain) characteristic of Rho family GEFs, while only the longer two isoforms also contain the AKAP domain. Therefore, these isoforms may function as scaffolding proteins to coordinate Rho signaling and protein kinase A signaling.
Google Domains is an internet domain name registration service offered by Google. Google Domains offers domain registration (including private domain registration), DNS hosting, DNSSEC, Dynamic DNS, domain forwarding, and email forwarding. It also offers one-click DNS configuration that connects the domains with Blogger, Google Sites, Squarespace, Wix.com, Weebly and Shopify.
From October 25, 2018 to October 26, the domain contact details of 1,500 domain owners using easyDNS were leaked in Whois query results due to a bug in a system provided by the second largest domain registrar in the world, Tucows, which easyDNS uses as its backend to manage domain names.
A domain, which is found in the central region adopts a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. The domain is predominantly found in the enzyme alpha-mannosidase.
On October 7, 2011, Conceited Apps, which had been allowing Comex to use the domain name for hosting sold the domain name jailbreakme.com to an allegedly "unknown" party. SaurikIT acquired the domain the next day.
SBG's Internet domain name, saudi-binladin-group.com, was registered on September 11, 2000, for one year, expiring on the same day as the September 11 attacks. The domain was later acquired by a domain speculator.
Domain implementation is the creation of a process and tools for efficiently generating a customized program in the domain.
Similarly, an integral domain is a Dedekind domain if and only if every divisible module over it is injective.
The N-terminal domain of yeast ECM25 protein has been identified as containing a lipid binding CRAL-TRIO domain.
One factor is called Time Domain Severity Factor (TDSF) and another one is the Frequency Domain Severity Factor (FDSF).
The Orange domain serves to regulate the choice of bHLH heterodimer partners. The C-terminal WRPW domain inhibits transcription.
RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.
SAP1A is one of a family of proteins that contains a unique DNA binding domain termed the ETS domain.
Lenient registration restrictions on certain ccTLDs have resulted in various domain hacks. Domain names such as `I.am`, `tip.it`, `start.
However, when ordered to dispatch forces to Shōnai Domain on April 1, 1868, Miharu Domain refused, citing its small size and military weakness. On July 26, 1868, through the intercession of Kōno Hironaka, a local samurai in the service of the imperial forces, Miharu Domain switched sides to the Satchō Alliance. This defection caught the defenders of Nihonmatsu Domain and Sendai Domain by surprise and hastened the ending of the war. Akita Akisue remained a domain governor until the abolition of the han system in July 1871.
The crystal structure of PRC1 has only recently been characterized in vitro. In 2013, PRC1 was illustrated as a lengthy molecule consisting of a C-terminal spectrin microtubule-binding domain, an extended rod domain, and an N-terminal dimerization domain. Consisting of an intricate arrangement of α-helices, the rod domain, together with the dimerization- conducting N terminus cooperate to facilitate binding of other proteins, such as Kinesin-4, to PRC1. PRC1’s rod domain adopts multiple conformations, all affected by its C-terminal spectrin domain.
Domain name front running is the practice whereby a domain name registrar uses insider information to register domains for the purpose of re-selling them or earning revenue via ads placed on the domain's landing page. By registering the domains, the registrar locks out other potential registrars from selling the domain to a customer. The registrar typically takes advantage of the five- day "domain tasting" trial period, where the domain can be locked without payment. The term was coined by domain investor and retired stockbroker Daniel Stager.
Prüfer domains can be characterized as integral domains whose localizations at all prime (equivalently, at all maximal) ideals are valuation domains. So the localization of a Bézout domain at a prime ideal is a valuation domain. Since an invertible ideal in a local ring is principal, a local ring is a Bézout domain iff it is a valuation domain. Moreover, a valuation domain with noncyclic (equivalently non-discrete) value group is not Noetherian, and every totally ordered abelian group is the value group of some valuation domain.
Or the project could be expanded in scope to include all hospitals as their domain. In a computer programming design, you define a domain by delineating a set of common requirements, terminology, and functionality for any software program constructed to solve a problem in the area of computer programming, known as domain engineering. The word domain is also taken as a synonym of application domain. > Domain in the realm of software engineering commonly refers to the subject > area on which the application is intended to apply.
The area of present-day Kamogawa was part of ancient Awa Province. Nichiren (1222 - 1282) was born in the Kominato district of Kamogawa, and his birthplace is commemorated at Tanjō-ji. During the Edo period, it was mostly tenryō territory controlled directly by the Tokugawa shogunate, with portions under the control of the feudal domains of Funagata Domain, Tateyama Domain, Iwasuki Domain and Tsurumaki Domain. The short-lived (1638-1690) Tōjō Domain and the Bakumatsu period Hanabusa Domain were also located within the borders of modern Kamogawa.
First generation CARs are composed of an extracellular binding domain, a hinge region, a transmembrane domain, and one or more intracellular signaling domains. The extracellular binding domain contains a single-chain variable fragment (scFv) derived from tumor antigen‐reactive antibodies that usually has a high specificity to a specific tumor antigen. All CARs contain the CD3ζ chain domain as the intracellular signaling domain, which is the primary transmitter of T cell activation signals. Second generation CARs add a co‐stimulatory domain, like CD28 or 4‐1BB.
This phosphatase, along with its paralogue, Shp1, possesses a domain structure that consists of two tandem SH2 domains in its N-terminus followed by a protein tyrosine phosphatase (PTP) domain. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the active site. Thus, Shp2 is auto-inhibited. Upon binding to target phospho- tyrosyl residues, the N-terminal SH2 domain is released from the PTP domain, catalytically activating the enzyme by relieving this auto-inhibition.
330px Domain engineering, like application engineering, consists of three primary phases: analysis, design, and implementation. However, where software engineering focuses on a single system, domain engineering focuses on a family of systems. A good domain model serves as a reference to resolve ambiguities later in the process, a repository of knowledge about the domain characteristics and definition, and a specification to developers of products which are part of the domain.
His wife was a daughter of Matsudaira Nobuiya of Yoshida Domain and he later married a daughter of Toyama Yoshimichi of Gujō Domain. In 1784, the domain was beset by crop failure and famine and was forced to borrow 2000 ryō from the shogunate. The following year, the domain mansion in Edo burned down, and the domain borrowed an additional 3000 ryō. He retired in 1797 and died in 1813.
The Arabic name امارات, romanized as emarat,ausregistry, First .emarat Arabic script domain name is live! , 7 May 2010 is the internationalized country code top-level domain for the United Arab Emirates.IDN News The ASCII name of this domain in the Domain Name System of the Internet is `xn--mgbaam7a8h`, using the Internationalizing Domain Names in Applications (IDNA) procedure in the translation of the Unicode representation of the script version.
This notion can be used to study the various characterizations of a Dedekind domain. In fact, this is the definition of a Dedekind domain used in Bourbaki's "Commutative algebra". A Dedekind domain can also be characterized in terms of homological algebra: an integral domain is a Dedekind domain if and only if it is a hereditary ring; i.e., every submodule of a projective module over it is projective.
Glis1 has an activation domain at its C-terminus and a repressive domain at its N-terminus. The repressive domain is much stronger than the activation domain meaning transcription is weak. The activation domain of Glis1 is four times stronger in the presence of CaM kinase IV. This may be due to a coactivator. A proline-rich region of the protein is also found towards the N-terminal.
Trees are generated using heuristic parsimony methods, and are based on protein domain architecture data for all genomes in SUPERFAMILY. Genome combinations, or specific clades, can be displayed as individual trees. Similar Domain Architectures This feature allows the user to find the 10 domain architectures which are most similar to the domain architecture of interest. Hidden Markov Models Produce SCOP domain assignments for a sequence using the SUPERFAMILY hidden Markov models.
This protein belongs to the Src homology 2-B (SH2B) adapter family. LNK contains 3 functional domains: a C-terminal Src homology 2 (SH2) domain, a pleckstrin homology (PH) domain, and a dimerization domain. The SH2 domain spans approximately 100 amino acid residues and binds phosphotyrosine-containing proteins such as kinases. The PH domain spans approximately 120 amino acid residues and binds the phosphatidylinositol lipids found in the cell membrane.
Both domain-general and domain-specific causes have been put forth. With respect to pure developmental dyscalculia, domain-general causes are unlikely as they should not impair one’s ability in the numerical domain without also affecting other domains such as reading. Two competing domain-specific hypotheses about the causes of developmental dyscalculia have been proposed – the magnitude representation (or number module deficit hypothesis) and the access deficit hypothesis.
Fukuoka castle was a Japanese domain of the Edo period. It was associated with Chikuzen Province in modern-day Fukuoka Prefecture on the island of Kyushu. The domain was also sometimes referred to as Chikuzen Domain, or as Kuroda Domain, after the ruling Kuroda family. Fukuoka Domain (Early 17th century) In the han system, Fukuoka was a political and economic abstraction based on periodic cadastral surveys and projected agricultural yields.
Often particles are considered single-domain if their saturation remanence is consistent with the single-domain state. More recently it was realized that a particle's state could be single-domain for some range of magnetic fields and then change continuously into a non-uniform state. Another common definition of single-domain particle is one in which the single-domain state has the lowest energy of all possible states (see below).
If there is more than one magnetic domain, the transition between one domain and its neighbor involves a rotation of the magnetization to form a domain wall. Domain walls move easily within the magnet and have a low coercivity. By contrast, a particle that is single- domain in all magnetic fields changes its state by rotation of all the magnetization as a unit. This results in a much larger coercivity.
Beyond the transmembrane domain is a SEA domain that contains a cleavage site for release of the large extracellular domain. The release of mucins is performed by sheddases. The extracellular domain includes a 20 amino acid variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. These repeats are rich in serine, threonine and proline residues which permits heavy o-glycosylation.
In abstract algebra, a Schreier domain, named after Otto Schreier, is an integrally closed domain where every nonzero element is primal; i.e., whenever x divides yz, x can be written as x = x1 x2 so that x1 divides y and x2 divides z. An integral domain is said to be pre-Schreier if every nonzero element is primal. A GCD domain is an example of a Schreier domain.
Often, the β-strands found in the pre-SET domain will form β-sheets with the β-strands of the SET domain, leading to slight variations to the SET domain structure. These small changes alter the target residue site specificity for methylation and allow the SET domain methyltransferases to target many different residues. This interplay between the pre-SET domain and the catalytic core is critical for enzyme function.
The road was named the or sometimes the . In addition to Aizu Domain, the route also proved popular with the sankin-kōtai retinues of Shibata Domain, Murakami Domain, Shōnai Domain and Yonezawa Domain. The route was closed from 1683 to 1723, when a landslide blocked the Kinugawa River creating a natural dam. When the dam burst in 1723 during torrential rains, 1200 people were killed by the flood in downstream Utsunomiya.
This enzyme participates in arginine and proline metabolism and aminoacyl-trna biosynthesis. It contains a conserved domain at the N terminus called arginyl tRNA synthetase N terminal domain or additional domain 1 (Add-1). This domain is about 140 residues long and it has been suggested that it is involved in tRNA recognition.
With the British settlement of Parramatta, Westmead was originally part of the domain of Government House. What is left of this domain, including Government House, form Parramatta Park. The name Westmead came into use when the governor's domain was first subdivided in 1859. The subdivision of the domain was completed in 1889.
Inuyama Castle The was a feudal domain in Owari Province, Japan. It was not officially designated as a domain by the Tokugawa Shogunate, when major domains were established, but was finally designated a domain in 1868. The domain was controlled from Inuyama Castle, which is located in present-day Inuyama, Aichi Prefecture.
The ZACR, in partnership with the Africa Union Commission (AUC), is the applicant for the dotAfrica domain in ICANN's new Top-level domain program. The ZACR has also partnered with the ZA Domain Name Authority (ZADNA), the South African Domain Name regulator, to implement the dotJoburg, dotCapetown, and dotDurban Top-level domains (TLDs).
In 1845 he was sent to Hamamatsu Domain. In 1845, Akimoto Yukitomo was transferred from Yamagata Domain to Tatebayashi. He was, along with Tokugawa Nariaki of Mito Domain, a strong supporter of the sonnō jōi movement. However, he opposed the actions of Chōshū Domain, and retired after receiving word of the Kinmon Incident.
FtsK is a transmembrane protein composed of three domains: FtsKN, FtsKL, and FtsKC. Through its N- domain and C-domain FtsK works to coordinate cell division and chromosome differentiation. The FtsKN domain is embedded in the cellular membrane by four transmembrane α-helices. The FtsKL domain extends from the membrane into the cytoplasm.
GPATCH11 has a molecular weight of about 33.3 kdal and is 285 amino acids long. It also comes in a second isoform that is 156 amino acids long. The gene contains a G-patch domain and the DUF 4138 domain. The G-patch domain itself is a novel domain found only in eukarya.
AEP multifutional primases also appear in bacteria and phages that infect them. They can display novel domain organizations with domains that bring even more functions beyond polymerization. Bacterial LigD () is primarily involved in the NHEJ pathway. It has an AEP superfamily polymerase/primase domain, a 3'-phosphoesterase domain, and a ligase domain.
Many Swedish domains were reserved for English words that end with "se". As of today, there are practically no such domain names left available on the domain prime market as the result of domain name speculation. Most of them can be bought on the domain secondary market. Only a few domains were developed.
CKK represents a domain that has evolved with the metazoa. The structure of this domain in murine hypothetical protein has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.
Moreover, as it is a cytoplasmtaic PAP it differs from nuclear PAPs in some aspects. While nuclear PAPs contain a catalytic domain and an RNA-binding domain, GLD-2 family members have only a catalytic domain.
The domain name ' (romanized as .bg; abbreviation of , tr. B'ălgarija) is an internationalized country code top-level domain (IDN ccTLD) for Bulgaria.Bulgaria moves to register Cyrillic Internet domain, Reuters, 23 June 2008; accessed 24 September 2008.
Protein SRP54 (named Ffh in the bacteria) is an essential component of every SRP. It is composed of three functional domains: the N-terminal (N) domain, the GTPase (G) domain, and the methionine-rich (M) domain.
In molecular biology, the EAL domain is a conserved protein domain. It is found in diverse bacterial signalling proteins. It is named EAL after its conserved residues. The EAL domain may function as a diguanylate phosphodiesterase.
Schematic of Human SMIM15 Domains There is one transmembrane domain located from amino acids 20 – 42. The other domains include a luminal domain from amino acids 1 - 19 and cytosolic domain from amino acids 43 - 74.
NET framework respectively. However, the emergence of the terms POJO and POCO reflect a growing view that, within the context of either of those technical platforms, domain objects should be defined purely to implement the business behaviour of the corresponding domain concept, rather than be defined by the requirements of a more specific technology framework. ; The naked objects pattern: Based on the premise that if you have a good enough domain model, the user interface can simply be a reflection of this domain model; and that if you require the user interface to be a direct reflection of the domain model then this will force the design of a better domain model.. ;Domain-specific modeling (DSM): DSM is DDD applied through the use of Domain-specific languages. ;Domain-specific language (DSL): DDD does not specifically require the use of a DSL, though it could be used to help define a DSL and support methods like domain-specific multimodeling.
Two online sources for public domain music are IMSLP (International Music Score Library Project) and Choral Public Domain Library (CPDL).
TMEM260 contains one conserved domain, DUF2723. The domain DUF2723 is conserved back to bacteria and its function is not known.
Domain disputes are handled by Domain Disputes Committee. Domains can be registered and renewed for 1, 2 and 3 years.
In March 2013 domain name registrars such as GoDaddy stopped accepting new registrations for .vg, .gd, and .tc domain names.
In mathematics, the noncommutative unique factorization domain is the noncommutative counterpart of the commutative or classical unique factorization domain (UFD).
Following the SH3-BM is a TAD (transcription activation domain) and a PDZ domain-binding motif (PDZ-BM) (Figure 1).
This region T is the domain of all triangles, and it is the default domain for all triangle-based functions.
It operates the domain name registry for the .lu domain and participates actively in the Internet exchange point LU-CIX.
The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). These nuclear hormone receptor proteins are the insect orthologs of the mammalian farnesoid X receptor (FXR) and retinoid X receptor (RXR) proteins, respectively. Based on sequence homology considerations, some researchers reserve the term USP for the EcR partner from lepidopteran and dipteran insects, and use RXR in all other instances. EcR and USP share the multi-domain architecture common to all nuclear hormone receptors, namely an N-terminal transcriptional activation domain (A/B domain), a DNA-binding domain (C domain, highly conserved between receptors), a linker region (D region), a ligand-binding domain (E domain, moderately conserved), and in some cases a distinct C-terminal extension (F-domain).
The , also known as the , was a domain of the Tokugawa Shogunate of Japan during the Edo period from 1600 to 1871. The Sendai Domain was based at Aoba Castle in Mutsu Province, in the modern city of Sendai, located in the Tōhoku region of the island of Honshu. The Sendai Domain was ruled for its existence by the tozama daimyō of the Date, and under the 'kokudaka system its income rating at 625,000 koku was the third-largest domain in Japan after the Satsuma Domain and Kaga Domain. The Sendai Domain was geographically the largest domain in northern Japan with its mostly-contiguous holdings covering most of southern Mutsu Province, including all of present-day Miyagi Prefecture, parts of southern Iwate Prefecture and northeastern Fukushima Prefecture.
Next to the LRR domain there is a single-pass transmembrane section. The intracelluar domain of BRI1 functions as a kinase and it is this domain triggers the phosphorylation cascade that results in changes of gene expression.
Austin-based Endeavor Real Estate Group owns the Domain 1 and Domain 5 office buildings. On March 8, 2018 Precourt Sports Ventures announced the Domain area would be their focus for a potential Major League Soccer Stadium.
A .co.nf second-level domain exists which is commonly misinterpreted as the real commercial second- level domain for the island. The domain is run by a web-hosting provider called biz.nf. As of 2 September 2019, .co.
Domain flipping may also involve the process of buying a valuable domain name and building a related website around it, all this with the objective of selling the domain and newly built website to an interested party.
The Internet country code top-level domain (ccTLD) .io is assigned to the British Indian Ocean Territory. The .io domain is administered by the Internet Computer Bureau, a domain name registry company based in the United Kingdom.
One of the major landrush periods that occurred was the .eu TLD (top level domain). The “.eu [domain] is the country code top-level domain (ccTLD) for the European Union” and it was approved in March 2005.
With over 150 million domain name registrations today, ccTLDs make up 40% of the total domain name industry."the Domain Name Industry Report" Country code extension applications began in 1985. The registered first extensions that year were .
The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases. The C-terminal dimerization domain contains the site for interaction with I-kappaB.
The L27 domain is a protein domain that is found in receptor targeting proteins Lin-2 and Lin-7 (LIN7A, LIN7B, LIN7C), as well as some protein kinases and human MPP2 protein. The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity. L27 domains form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The L27_2 domain is a protein-protein interaction domain capable of organising scaffold proteins into supramolecular assemblies by formation of heteromeric L27_2 domain complexes.
They repeatedly build similar systems within a given domain with variations to meet different customer needs. Rather than building each new system variant from scratch, significant savings may be achieved by reusing portions of previous systems in the domain to build new ones. The process of identifying domains, bounding them, and discovering commonalities and variabilities among the systems in the domain is called domain analysis. This information is captured in models that are used in the domain implementation phase to create artifacts such as reusable components, a domain-specific language, or application generators that can be used to build new systems in the domain.
The GAF domain is a type of protein domain that is found in a wide range of proteins from all species. The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain solved by Ho and colleagues showed that this domain shared a similar fold with the PAS domain. In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which binds both cGMP and cAMP.
In general, the integral closure of a noetherian domain of dimension at most 2 is noetherian; Nagata gave an example of dimension 3 noetherian domain whose integral closure is not noetherian. A nicer statement is this: the integral closure of a noetherian domain is a Krull domain (Mori–Nagata theorem). Nagata also gave an example of dimension 1 noetherian local domain such that the integral closure is not finite over that domain. Let A be a noetherian integrally closed domain with field of fractions K. If L/K is a finite separable extension, then the integral closure A' of A in L is a finitely generated A-module.
If the server for a zone is not also authoritative for its parent zone, the server for the parent zone must be configured with a delegation for the zone. When a domain is registered with a domain name registrar, the zone administrator provides the list of name servers (typically at least two, for redundancy) that are authoritative for the zone that contains the domain. The registrar provides the names of these servers to the domain registry for the top level domain containing the zone. The domain registry in turn configures the authoritative name servers for that top level domain with delegations for each server for the zone.
This marked the start of Itoigawa Domain. He has transferred in 1695 to Maruoka Domain and the territory reverted to tenryō status. Itoigawa Domain was created again in 1699, this time as a 10,000 koku holding for Honda Tsukeyoshi, who had been elevated from hatamoto status. He was transferred to Iiyama Domain in 1717.
In algebra, a Mori domain, named after Yoshiro Mori by , is an integral domain satisfying the ascending chain condition on integral divisorial ideals. Noetherian domains and Krull domains both have this property. A commutative ring is a Krull domain if and only if it is a Mori domain and completely integrally closed.Bourbaki AC ch.
The structure of the C-terminal DUF1608 domain of the Methanosarcinales S-layer Tile Protein MA0829. A, the C-terminal DUF1608 domain of MA0829 with domain I colored red, domain II in blue, and the connector subdomain in yellow. B, the crystallographic dimer of the MA0829 CTR. C, a trimer of crystallographic CTR homodimers.
The copyright on the 1910 film entered public domain in 1938. Baum's Oz Film Manufacturing Company movies entered public domain in 1942. and then the 1925 Larry Semon movie version of The Wizard of Oz entered the public domain in 1954. These films remain the only Oz live action movies in the public domain.
The activated region of the delta toxin is composed of three distinct structural domains: an N-terminal helical bundle domain () involved in membrane insertion and pore formation; a beta-sheet central domain involved in receptor binding; and a C-terminal beta- sandwich domain () that interacts with the N-terminal domain to form a channel.
The domain name ae is the country code top-level domain (ccTLD) in the Domain Name System of the Internet for the United Arab Emirates. It is administered by .aeDA which is part of the UAE Telecommunications Regulatory Authority. The internationalized country code top-level domain in the Arabic alphabet of the UAE is امارات.
MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene. MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230.
The domain was then awarded in 1610 to Matsudaira Tadateru, the 6th son of Tokugawa Ieyasu; however, he was dispossessed in 1606 and the domain was suppressed. In 1616, Matsudaira Tadamasa, the son of Yūki Hideyasu was awarded a 130,000 koku holding in northern Shinano, and chose Matsushiro as the location for his castle. The marked the start of Matsushiro Domain. He was transferred to Takada Domain in Echigo Province after only three years, and the domain went to Sakai Tadakatsu, who was in turn transferred to Shonai Domain in Dewa Province in 1622.
In molecular biology, the calmodulin-regulated spectrin-associated CKK domain (also known as the CKK domain) is a domain which occurs at the C-terminus of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal. This domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function.
MADS-box genes were detected in nearly all eukaryotes studied. While the genomes of animals and fungi generally possess only around one to five MADS-box genes, genomes of flowering plants have around 100 MADS-box genes. Two types of MADS-domain proteins are distinguished; the SRF-like or Type I MADS-domain proteins and the MEF2-like (after MYOCYTE-ENHANCER-FACTOR2) or Type II MADS-domain proteins. SRF-like MADS-domain proteins in animals and fungi have a second conserved domain, the SAM (SRF, ARG80, MCM1) domain.
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42-binding domain. In contrast, members of the GCK subfamily (MAP4K2), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain.
The structure of C1q and Tumor Necrosis Factor Related Protein 5 (C1QTNF5) which is also called CTRP5 has three essential domains. The first domain is a single peptide which is located in N-terminal, the second domain is a collage domain and the third domain is a globular complement 1q (gC1q) that exists in the C-terminal domain. The single mutation S163R is found in the gC1q domain which is the main reason for Late-onset retinal degeneration disease(L-ORD). C1QTNF5 is a part of the C1q family.
Dell EMC offers two disk backup devices. The Data Domain device, which EMC acquired from Data Domain in 2009. The Data Domain device de-duplicates the data at the destination, which reduces the overhead on the host. With throughput up to 68 TB/hour, Data Domain systems make it possible to complete more backups in less time and provide faster, more reliable restores. The Data Domain Operating System (DD OS) is the intelligence behind Data Domain systems that makes them the industry’s most reliable and cloud-enabled protection storage.
The domain was also raised in status from a jin'ya domain to a castle domain in 1850. During the Bakumatsu period, the samurai of the domain were sharply divided between a conservative faction led by the 11th daimyō, Hori Naoyoshi, and a pro-Sonnō jōi faction. During the Boshin War, Hori Naoyoshi led the domain into the Ōuetsu Reppan Dōmei, but he switched sides after only a few months. In July 1871, with the abolition of the han system, Muramatsu Domain briefly became Muramatsu Prefecture, and was merged into the newly created Niigata Prefecture.
Takada Domain was revived in 1685 for Inaba Masamichi, who ruled until his transfer to Sakura Domain in 1707. He was followed by Toda Tadazane, formerly of Sakura Domain, who held the post to his transfer to Utsunomiya Domain in 1710. Takada was then assigned to a junior branch of the Hisamatsu-Matsudaira clan, who ruled uneventfully from 1710 until their transfer to Shirakawa Domain in 1741. Sakakibara Masazumi was transferred from Himeji Domain in 1741 at the age of six as punishment for issues created by his father, Sakakibara Masamine.
The ring of entire functions on the open complex plane C form a Prüfer domain. The ring of integer valued polynomials with rational number coefficients is a Prüfer domain, although the ring Z[X] of integer polynomials is not, . While every number ring is a Dedekind domain, their union, the ring of algebraic integers, is a Prüfer domain. Just as a Dedekind domain is locally a discrete valuation ring, a Prüfer domain is locally a valuation ring, so that Prüfer domains act as non- noetherian analogues of Dedekind domains.
However, after Kubota Domain switched sides to favor the Meiji government, Shinjō Domain soon followed. Neighboring Shōnai Domain, outraged by the betrayal, sent its army to invade Shinjō Domain, and after a fierce battle, destroyed Shinjō Castle and much of the surrounding castle town. Masazane escaped to Kubota Castle, where he remained in exile for 70 days until his domain was liberated by forces loyal to the new Meiji government. On June 2, 1869, the new government awarded Shinjō Domain with an increase in revenues of 15,000 koku.
However, after Kubota Domain switched sides to favor the Meiji government, Shinjō Domain soon followed. Neighboring Shōnai Domain, outraged by the betrayal, sent its army to invade Shinjō Domain, and after a fierce battle, destroyed Shinjō Castle and much of the surrounding castle town. The 11th daimyō, Tozawa Masazane escaped to Kubota Castle, where he remained in exile for 70 days until his domain was liberated by forces loyal to the new Meiji government. On June 2, 1869, the new government awarded Shinjō Domain with an increase in revenues of 15,000 koku.
These experiments are crucial to understanding domain wall nucleation and propagation which would be necessary for the creation of complex logic circuits based on domain wall mechanics. Many properties of domain walls are still not fully understood and one particularly outstanding issue is of the magnitude and size of the resistance associated with current passing through domain walls. Both positive and negative values of domain wall resistance have been reported, leaving this an open area for future research. An example of a simple device that utilizes pinned domain walls is provided by reference.
Public Domain Day is an observance of when copyrights expire and works enter into the public domain. This legal transition of copyright works into the public domain usually happens every year on 1 January based on the individual copyright laws of each country. The observance of a "Public Domain Day" was initially informal; the earliest known mention was in 2004 by Wallace McLean (a Canadian public domain activist), with support for the idea echoed by Lawrence Lessig. Several websites list the authors whose works are entering the public domain each January 1.
All ETS (Erythroblast Transformation Specific)family members are identified through a highly conserved DNA binding domain, the ETS domain, which is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. As well as DNA- binding functions, evidence suggests that the ETS domain is also involved in protein-protein interactions. There is limited similarity outside the ETS DNA binding domain. Other domains are also present and vary from ETS member to ETS member, including the Pointed domain, a subclass of the SAM domain family.
An important motivation for using digital certificates with SSL/TLS was to add trust to online transactions by requiring website operators to undergo vetting with a certificate authority (CA) in order to get a certificate. However, commercial pressures have led some CAs to introduce "domain-validated" certificates. Domain-validated certificates existed before validation standards, and generally only require some proof of domain control. In particular, domain-validated certificates do not assert that a given legal entity has any relationship with the domain, although the domain may resemble a particular legal entity.
The framework states the ability to represent the domain as domain appropriateness. The statement appropriateness can be a bit vague, but in this particular context it means able to express. You should ideally only be able to express things that are in the domain but be powerful enough to include everything that is in the domain. This requirement might seem a bit strict, but the aim is to get a visually expressed model which includes everything relevant to the domain and excludes everything not appropriate for the domain.
The domain name jobs is a sponsored top-level domain (sTLD) in the Domain Name System of the Internet. As indicated by its name, the domain is restricted to employment-related sites. The domain was approved by ICANN on April 8, 2005 as part of the second group of new TLD applications submitted in 2004. It was installed in the DNS root in September 2005, and began accepting registrations later in the year.
A domain controller (DC) is a server computer that responds to security authentication requests within a computer network domain. It is a server on a network that is responsible for allowing host access to domain resources. It authenticates users, stores user account information and enforces security policy for a domain. It is most commonly implemented in Microsoft Windows environments (see Domain controller (Windows)), where it is the centerpiece of the Windows Active Directory service.
Arginine decarboxylase is a multimer of protein subunits. For instance, the form of this enzyme in E. coli is a ca. 800 kDa decamer of identical subunits, and is composed as a pentamer of dimers. Each subunit can be divided into five domains: (1) the amino-terminal wing domain, (2) the linker domain, (3) the PLP-binding domain, (4) the aspartate aminotransferase- (AspAT-) like small domain, and (5) the carboxy-terminal domain.
Most ICLs that have been characterised to date contain only one domain (the catalytic domain). However, in the isoform 2 of _M. tuberculosis_ ICL, two domains were found. Through structural and kinetic studies, the C-terminal domain was found to be a regulatory domain, which dimerises with the corresponding C-terminal domain from another subunit (of the ICL2 tetramer) upon the binding of acetyl coenzyme A to activate the catalytic activity of the enzyme.
Atg3 consists of three domains, an N-terminal domain, a catalytic domain and a C-terminal domain. The catalytic domain contains a cysteine residue within an HPC motif, this is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex. The small C-terminal domain is likely to be a distinct binding region for the stability of the autophagosome complex. It carries a highly characteristic conserved FLKF sequence motif.
Some authors add the requirement that a Dedekind domain not be a field. Many more authors state theorems for Dedekind domains with the implicit proviso that they may require trivial modifications for the case of fields. An immediate consequence of the definition is that every principal ideal domain (PID) is a Dedekind domain. In fact a Dedekind domain is a unique factorization domain (UFD) if and only if it is a PID.
Main articles: JAKs and STATs There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins. There are 7 STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.
VAD1 analog of StAR-related lipid transfer (VASt) is a steroidogenic acute regulatory protein‐related lipid transfer (StART)-like lipid-binding domain first identified in the vad1 (vascular associated death1) protein in Arabidopsis thaliana (mouse-ear cress ). Proteins containing these domains are found in eukaryotes and usually contain another lipid-binding domain, typically the GRAM domain and sometimes the C2 domain in plants and the integral peroxisomal membrane peroxin Pex24p domain in oomycetes.
ZBTB32 recruits corepressors, such as N-CoR and HDACs to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with Blimp-1, to suppress the transcription of genes . It contains a N-terminal BTB/POZ domain (IPR000210) or a SKP1/BTB/POZ domain (IPR011333), and three C-terminal zinc fingers, Znf_C2H2_sf. (IPR036236), Znf_C2H2_type domain (IPR013087), a Znf_RING/FYVE/PHD domain (IPR013083), followed by a putative UBZ4 domain.
Once a domain is modeled, it can be tested independent of the target implementation by executing the model. Each domain can be verified and validated independent of any other domain. This allows errors detected to be associated with the domain and independent of other system concerns. Verification will involve such things as human review of the models, performed by experts in the relevant domain, and automated checking of the Executable UML semantics. i.e.
AlSaudiah () is the Internationalized country code top-level domain for Saudi Arabia. Only persons or entities related to Saudi Arabia are able to register. The top-level domain is managed by the Saudi Network Information Center (SaudiNIC). The ASCII name of this domain in the Domain Name System is xn--mgberp4a5d4ar, obtained by application of the Internationalizing Domain Names in Applications (IDNA) rules for the translation of the Unicode representation of the script version.
In order for the exchange of information to be organized and searchable on the World Wide Web domain names are used. Domain names are substitutes for IP addresses, which are presented numerically, in order to further simplify the process of searching for information on the Internet. Domain name servers maintain the list that matches domain names to IP addresses. There are two types of domain names TLDs or Top Level Domains which include: .
Takasawa was born in 1781 as the son of the previous daimyo of Tsu Domain, Tōdō Takasato. However, in 1790, he was adopted by Tōdō Takasawa, the daimyo of Hisa Domain, a subsidiary domain of Tsu domain. Takasawa died the same year, and although only nine years old, Takasawa became daimyo of Hisai. The domain suffered from severe financial problems due to the frequent deaths of its lords, and lack of fiscal control.
Active Directory Domain Services (AD DS) is the cornerstone of every Windows domain network. It stores information about members of the domain, including devices and users, verifies their credentials and defines their access rights. The server running this service is called a domain controller. A domain controller is contacted when a user logs into a device, accesses another device across the network, or runs a line-of-business Metro-style app sideloaded into a device.
The word quantifier in the introduction refers to a variable used in a domain of discourse, a collection of objects under discussion. In daily life, the domain of discourse could be 'apples', or 'persons', or even everything. In a more technical arena, the domain of discourse could be 'integers', say. The quantifier variable x, say, in the given domain of discourse can take on the 'value' or designate any object in the domain.
The partial cleavage stimulation factor domain, or partial CstF domain, is a protein domain that occurs in proteins from apicomplexan parasites. Currently (as of 2012), little is known about the function of this domain. However, it is homologous to the amino-terminal part of the cleavage stimulation factor, which is thought to be involved with mRNA maturation in mammals. Proteins with this domain have been detected in the malaria parasite Plasmodium falciparum nucleus.
The domain maintained its primary residence (kamiyashiki) in Edo at Kanda, until the An'ei (1772–81) period, and at Hanjo at the time of the Meiji restoration.Edo daimyo.net In February 1869, the final daimyō of Sagara Domain, Tanuma Okitaka, was transferred by the new Meiji government to the short-lived Kokubo Domain in Kazusa Province and Sagara Domain was absorbed into the new Shizuoka Domain created for retired ex-Shōgun Tokugawa Yoshinobu.
VTC2 has three recognized domains: an N-terminal SPX domain, a large central CYTH-like domain and a smaller transmembrane VTC1 (DUF202) domain. The SPX domain is found in Syg1, Pho81, XPR1 (SPX), and related proteins. This domain is found at the amino termini of a variety of proteins. In the yeast protein, Syg1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal.
Hagi Meirinkan was a han school located in the Chōshū Domain of Japan. The school was one of the three major educational institutions in Japan, along with the Kōdōkan in Mito Domain and Shizutani School in Okayama Domain.
The domains are digitally signed using Domain Name System Security Extensions (DNSSEC). The zone files of each domain also define one subdomain name. The third-level domain name www resolves to the IP addresses of the parent domains.
Prior to the introduction of .me, the most used domain in Montenegro was the second-level domain .cg.yu under .yu, the Internet domain name of Montenegrin Internet service provider T-Crnogorski Telekom, which was allowed to such organisations.
Steady state calculation methods can be sorted into time-domain algorithms (time domain sensitivities, shooting) and frequency-domain algorithms (harmonic balance) methods, are the best choice for most microwave circuits excited with sinusoidal signals (e.g. mixers, power amplifiers).
As the result, RBPs can bind RNA with higher specificity and affinity than single domain. RNA-binding protein database has three main specific categories. They are RNA recognition motif (RRM), K-Homology domain (KH domain) and zinc fingers.
A sterol-sensing domain (SSD) is a protein domain which consists of 180 amino acids forming five transmembrane segments capable of binding sterol groups. This type of domain is present in proteins involved in cholesterol metabolism and signalling.
FERM Domain Containing 4A is a gene, located on human Chromosome 10 at 10p13, that encodes FERM Domain Containing Protein 4A.
FERM Domain Containing 4B is a gene, located on human Chromosome 3 at 3p14.1, that encodes FERM Domain Containing Protein 4b.
During the Secret Wars storyline, a version of Dark Beast resides in the Battleworld domain known as the Domain of Apocalypse.
Kubota Domain was inherited by Satake Yoshimine, the second son of Satake Yoshinaga of Iwasaki Domain and grandson of Satake Yoshizumi.
Domain name registrars such as GoDaddy have stopped accepting new registrations for .vg, .tc and .gd domain names since March 2013.
The N-terminal domain folds into two alpha-helices and one beta-strand. This protein domain is vital in assisting multimerisation.
In molecular biology the protein domain S-adenosylmethionine synthetase N terminal domain is found at the N-terminal of the enzyme.
SAM domain, SH3 domain and nuclear localization signals 1 is a protein that in humans is encoded by the SAMSN1 gene.
It employs one cofactor, pyridoxal phosphate. Many alliinases contain a novel N-terminal epidermal growth factor-like domain (EGF-like domain).
Fic domain was found in bacteria, eukaryotes and archaea and can be found organized in almost hundred different multi-domain assemblies.
The ball domain is electrostatically attracted to the inner channel domain. When the ion channel is activated, the inner channel domain is exposed, and within milliseconds the chain will fold and the ball will enter the channel, occluding ion permeation. The channel returns to its closed state, blocking the channel domain, and the ball leaves the pore.
Biosynthesis reactions that interchange the KR domain from TYLS with the KR domain from DEBS lead to products with different stereochemistry. Other studies have elucidated the stereospecificity of the DEBS DH domain by co-incubating the DEBS DH domain with the TYLS KR from module 1 and comparing the product to that produced by the DEBS system.
Sadamasa's son Toki Sadayoshi (1579–1618) was moved in 1617 to Takatsuki Domain (30,000 koku) in Settsu Province. In 1619, his descendants were transferred to Soma; in 1627 to Kaminoyama Domain in Dewa Province; in 1712 to Tanaka Domain in Suruga Province; and finally, from 1742 to 1868 in Numata Domain (35,000 koku) in (Kōzuke Province).
To implement an FDTD solution of Maxwell's equations, a computational domain must first be established. The computational domain is simply the physical region over which the simulation will be performed. The E and H fields are determined at every point in space within that computational domain. The material of each cell within the computational domain must be specified.
The company purchased i.net, a major ICANN-approved internet registry, to process and manage its portfolio of domain names purchases. By 2011, FMA held over 120,000 domain names, though Al-Ghanim said, "I haven't been an active buyer lately." In 2016, FMA reversed a longstanding policy not to sell domain names, and began offloading parts of its domain portfolio.
This results in a partial detachment of the catalytic domain from the disk-like apple domains, still linked to the fourth domain with a disulfide bond, but now farther from the third domain. This is thought that this exposes the factor IX binding site of the third apple domain, allowing factor XI's protease activity on it.
ZGRF1 contains a DUF2439 domain (domain of unknown function), zf-GRF domain, and AAA_11 and an AAA_12 domain (ATPases associated with diverse cellular activities). DUF domains are involved in telomere maintenance and meiotic segregation. AAA_11 and AAA_12 contain a P-loop motif which are involved in conjugative transfer proteins. Other helicase domains are also present in c4orf21 orthologs.
The first and second helices interact with the serine/threonine kinase Raf-1 and the second and third helices are the sites of the BAG domain interaction with the ATPase domain of Hsc70/Hsp70. Binding of the BAG domain to the ATPase domain is mediated by both electrostatic and hydrophobic interactions in BAG-1 and is energy requiring.
One important consequence of the theorem is that the integral closure of a Dedekind domain A in a finite extension of the field of fractions of A is again a Dedekind domain. This consequence does generalize to a higher dimension: the Mori–Nagata theorem states that the integral closure of a noetherian domain is a Krull domain.
Cargo examination officers are issued polo shirts due to their warm operational environment. In 2016, a distinctive ICC domain insignia was designed for each domain to serve as a symbol of common identity for all HT officers operating in the domain. The domain insignia also encourages a greater sense of belonging and closer collaboration among Home Team officers.
PH domain modules (maroon) into two different proteins. The simplest multidomain organization seen in proteins is that of a single domain repeated in tandem. The domains may interact with each other (domain-domain interaction) or remain isolated, like beads on string. The giant 30,000 residue muscle protein titin comprises about 120 fibronectin-III-type and Ig- type domains.
This response contains a new domain, e.g. , indicating dCDN and the original domain and an NS record that maps this new domain to a request router in dCDN. # The UE does a DNS lookup using the new domain (). A request router in dCDN responds to this request with the IP address of a suitable delivery node.
Two bison located in the Canadian Domain of the Toronto Zoo. The Canadian Domain is situated in the Rouge Valley. The Canadian Domain was built in accompaniment with the Canadian Domain Ride, which exhibited North American animals in their native environment. Featured species in this area include wood bison, moose, bald eagles, cougars, lynxes, raccoons, and grizzly bears.
Sedo (an acronym for Search Engine for Domain Offers and stylised sedo) is a domain name and website marketplace and domain parking provider based in Cambridge, Massachusetts and Cologne, Germany. The company, which is a subsidiary of German-based United Internet, has more than 16 million domain names listed on its website for buying and selling.
The sole proteins containing this domain identified in human are GRAMD1A/Aster-A, GRAMD1B/Aster-B and GRAMD1C/Aster-C (with the VASt domain referred to as an Aster domain). These sterol transfer proteins together with GRAMD2A and GRAMD2B are LAM family proteins, although the latter two lack the VASt domain. Like LAM proteins, GRAMD1 proteins preferentially transfer sterols.
Domain slamming (also known as unauthorized transfers or domain name registration scams) is a scam in which the offending domain name registrar attempts to trick domain owners into switching from their existing registrar to theirs, under the pretense that the customer is simply renewing their subscription to their current registrar. The term derives from telephone slamming.
Data Domain Corporation was an Information Technology company from 2001-2009 specializing in target-based deduplication solutions for disk-based backup."Data Domain, an EMC company." Data Domain. It was acquired in 2009 by EMC Corporation, and the Dell EMC Data Domain product line has been Dell EMC's flagship platform for backup, archive and disaster recovery ever since.
Ikoma Takatoshi was a Japanese daimyō of the early Edo period, who ruled the Takamatsu Domain. He was the son-in-law of Doi Toshikatsu. Takatoshi lost rulership of the Takamatsu domain due to an uprising within the fief. The shogunate attaindered his domain, and transferred him to the much smaller Yashima Domain in Dewa Province.
In molecular biology, the protein domain Stirrup is a domain, found only in found in the domain, archaea. The Stirrup protein domain is found in prokaryotic protein ribonucleotide reductases. It obtains its name due to its resemblance to an old fashioned Japanese stirrup. Stirrip has a molecular mass of 9 kDa and is folded into an alpha/beta structure.
These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential. It also mediates homodimer formation of these proteins.
The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit.
Sasayama Castle ' was a Japanese domain of the Edo period, located in Tanba Province. It was founded in 1609, when Matsudaira Yasushige moved there from the Yakami Domain. The domain changed hands several times until 1748, when it was given to Aoyama Tadatomo. The Aoyama family remained there until 1868; the domain itself was abolished in 1871.
DOMINE is a database of known and predicted protein domain interactions (or domain-domain interactions). It contains interactions observed in PDB crystal structures, and those predicted by several computational approaches. DOMINE uses Pfam HMM profiles for protein domain definitions. The DOMINE database contains 26,219 interactions among 5,410 domains), which includes 6,634 known interactions inferred from PDB structure data.
The goal of filter design is to remove the undesired component of a signal. Conventionally, we can just filter in the time domain or in the frequency domain individually as shown below. Image:filter tf.jpg The filtering methods mentioned above can’t work well for every signal which may overlap in the time domain or in the frequency domain.
"URL Masking - Attainment and Prevention". WillMaster.com. Masking does not affect the content of the actual website; it only covers up the original URL/domain name. Domain masking prevents users from being able to see the actual domain website, whether it be due to length or privacy/security issues."Forwarding or Masking Your Domain". GoDaddy.com. 2013-12-10.
His son, Honda Tadanaga was transferred to Kariya Domain in 1710. He was replaced by Matsudaira Terusada from Takasaki Domain, He returned to Takasaki in 1717, trading placed with Manabe Akifusa, a close confidant of Shōgun Tokugawa Ienobu. His adopted heir, Manabe Akitoki was transferred to Sabae Domain. In 1720, Naitō Kazunobu was transferred to Murakami from Tanaka Domain.
His wife was a daughter of Matsudaira Yasutō of Hamada Domain, and his son and heir was Manabe Akizane. He had several other children, including Ōkōchi Nobuhisa (daimyō of Yoshida Domain), Ōkōchi Masatada (daimyō of Ōtaki Domain), and Manabe Akimichi, the final daimyō of Sabae Domain. Masatoshi Ōkōchi, the third president of RIKEN, was the son of Ōkōchi Masatada.
Within each of the alpha and beta subunits there is a large extracellular domain, a transmembrane domain and a short cytoplasmic domain. The extracellular domain is where the ligand binds through the use of divalent cations. In general, increases affinity, promotes adhesion to cells, and decreases cell adhesion. Integrins regulate their activity within the body by changing conformation.
GRS Domains is a domain registry service provider based in Gibraltar. GRS Domains succeeded Famous Four Media as the operator of the Domain Venture Partners (DVP) gTLD portfolio in 2018 after an investor revolt in DVP. The company has said that it will be seeking to curb domain abuse that had thus far characterized the domain. They bid for .
When the nuclease is unbound to DNA, the endonuclease domain is sequestered by the DNA-binding domain and is released through a conformational change in the DNA-binding domain upon binding to its recognition site. Cleavage only occurs upon dimerization, when the recognition domain is bound to its cognate site and in the presence of magnesium ions.
The catalytic domain of Beta-galactosidases have a TIM barrel core surrounded several other largely beta domains. The sugar binding domain of these proteins has a jelly- roll fold. These enzymes also include an immunoglobulin-like beta-sandwich domain.
Sometimes, domain name speculation involves finding domain names early in a market, particularly when a new top-level domain is launched, registering them and waiting until the market grows to sell them. Domains such as voice.com, sex.com, and fund.
ACAD8 functions as a homotetramer and has an overall structure is similar to other acyl-CoA dehydrogenases. The functional protein contains an NH2-terminal alpha-helical domain, a medial beta-strand domain and a C-terminal alpha- helical domain.
Control servers may also hop from DNS domain to DNS domain, with domain generation algorithms being used to create new DNS names for controller servers. Some botnets use free DNS hosting services such as DynDns.org, No-IP.com, and Afraid.
Private registries operate at a technical level identical to official domain registries using the well-known principles of operation of the Domain Name System. In addition, the registries may also operate a WHOIS service to publish domain name information.
The Nigeria Internet Registration Association (NIRA) oversees Nigeria's country code top-level domain, .ng. Registration of domain names are handled by NIRA certified registrars. It uses the Registry–Registrar–Registrant model in operating and managing the top-level domain.
These two analogues also have less potency for the C-domain which shows that the C-domain prefers pseudo-phenylalanine group in P1 position. Modeling of RXPA380-ACE complex showed that the pseudo-proline residue of the inhibitor was surrounded by amino acids similar to that of the N-domain thus interactions with S2’ domain might not be responsible for the selectivity of RXPA380. 7 of 12 amino acids surrounding tryptophan are the same in C- and N-domain, the biggest difference is that 2 bulky and hydrophobic amino acids in the C-domain have been replaced with 2 smaller and polar amino acids in the N-domain. This indicates that low potency of RXPA380 for N-domain is not because the S2’ cavity does not accommodate the tryptophan side chain but rather that important interactions are missing between the tryptophan side chain and the amino acids of the C-domain.
After TLS encryption is established, the HTTP header reroutes to another domain hosted on the same CDN. Domain fronting is a technique for internet censorship circumvention that uses different domain names in different communication layers of an HTTPS connection to discreetly connect to a different target domain than is discernable to third parties monitoring the requests and connections. Due to quirks in security certificates, the redirect systems of the content delivery networks (CDNs) used as 'domain fronts', and the protection provided by HTTPS: for any given domain name, censors are typically unable to differentiate circumvention ("domain-fronted") traffic from overt non-fronted traffic. As such they are forced to either allow all traffic to the domain front—including circumvention traffic—or block the domain front entirely, which may result in expensive collateral damage and has been likened to "blocking the rest of the internet".
PuntuLLI Associationlisted by cityTLD as a Top Level Domain initiative fights for a Top Level Domain for the Leonese language and culture.
These changes may signal up to the N-terminal domain or down to the C-terminal domain to alter protein- protein interactions.
It has an N-terminal Rossmann-fold domain and a C-terminal C-W/Y domain, similar to those of other YARSs.
As Kosovo does not have its own domain, the territory governed by the Republic of Kosovo continues to use the .al domain.
Conversely, the Habc domain can again disassociate with the SNARE domain leaving syntaxin free to associate with both SNAP-25 and synaptobrevin.
MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.
A second top-level domain will be used for Algeria, intended for domain names in the local language, using Arabic characters: الجزائر.
CM domain registrar Netcom.cm, sold over $500,000 in .cm domain names the first day and over $2 million in the first week.
Signal peptide, CUB domain and EGF like domain containing 1 is a protein that in humans is encoded by the SCUBE1 gene.
BetOnline has switched to the Betonline.ag domain name. Their Betonline.com domain is still active but they told their partners that the Betonline.
The Fidelis Center subsequently sold the domain to Fidelis, a related, but independent 501(c)4 organization which operates the domain today.
Similar to PAK1, PAK2 contains a p21-binding domain (PBD) and an auto-inhibitory domain (AID) and exists in an inactive conformation.
Zaire's top-level domain was ".zr". It has since changed to ".cd"."IANA Report on Deletion of the .zr Top-Level Domain".
The epsin N-terminal homology (ENTH) domain is a structural domain that is found in proteins involved in endocytosis and cytoskeletal machinery.
Aramis proposed Unlight while José liked Domain. In the end they decided to join the two words and Unlight Domain was born.
Highly conserved phosphatase domain is in central part of the protein. This catalytic domain is flanked on the N-terminal side by the PH-like domain that binds phosphatidylinositol-3,4,5-triphosphate (PI(3,4,5)P3) and is overlapped on C-terminus with the C2 domain that binds phosphatidylinositol-3,4-bisphosphate (PI(4, 5)P2). The C-tail is not structured, but contains a proline-rich region that forms the motif for binding SH3 domain and also contains sequence containing tyrosine 915 (Y915) and tyrosine 1022 (Y1022) (in human cell) that is typical for interaction with the phosphotyrosine binding domain (PTB domain). Phosphatase activity of SHIP1 can be allosteric regulated by phosphorylation of the catalytic domain on serine 440 (Ser440), this phosphorylation is mediated by cAMP-dependent protein kinase A (PKA).
Matrix metalloproteases contain five conserved domains/sequence motifs: # Signal peptide sequence, which directs the enzyme into the rough endoplasmic reticulum during synthesis # Propeptide domain, which is cleaved to activate the enzyme # Catalytic domain, which contains the conserved Zn2+ binding region and mediates enzyme activity # Hemopexin domain, which provides the substrate specificity # Small hinge region, which allows the hemopexin domain to bring the substrate to the active core of the catalytic domain There is also a subfamily of the matrix metalloproteases, the membrane-type MMPs (MT-MMPs) which contain an additional transmembrane domain and a short cytoplasmic domain. After activation of MMPs by removal of the propeptide domain, their activity is regulated by TIMPs. TIMPs specifically and reversibly inhibit the activity of MMPs. So far there have been identified four members of the family, TIMP1–4.
The protein sequence is predicted to contain a signal peptide (1 aa to 24 aa), an extracellular domain (25 aa to 100 aa), a transmembrane domain (101 aa to 121 aa), and a cytoplasmic domain (122 aa to 215 aa).
This increases the stability of the neck domain. There are seven different type of neck domains. They are as follows: ISneck1, ISneck2, HANS connector, DALL-1, DALL-2, DALL-3, and the neck domain. This entry focuses on the ISneck domain.
Feature oriented domain analysis (FODA) is a domain analysis method which introduced feature modelling to domain engineering. FODA was developed in 1990 following several U.S. Government research projects. Its concepts have been regarded as critically advancing software engineering and software reuse.
The domain name moe is a top-level domain (TLD) in the Domain Name System of the Internet. Its name comes from the Japanese slang word moe, indicating its intended purpose in the marketing of products or services deemed moe.
Matsumoto Castle, administrative headquarters of Matsumoto Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Shinano Province, Honshū. The domain was centered at Matsumoto Castle,"Matsumoto Castle" at JapaneseCastleExplorer.com; retrieved 2013-7-2.
The domain name .video is a top-level domain in the Domain Name System of the Internet. Its name suggests the intended use by producers, bloggers, videographers to showcase pod-casts to broadcasts, reach out and create an instant recall value.
The domain name is a generic top-level domain (gTLD) in the Domain Name System of the Internet. It is intended for use by individuals for representation of their personal name, nicknames, screen names, pseudonyms, or other types of identification labels.
The Japanese Infoseek website, as of 2019 The "infoseek.com" domain name redirects to "go.com" and the Infoseek brand name is no longer used in North America. However, the Australian domain and the Japanese domain still operate with the Infoseek name.
The KASH domain proteins cross the outer nuclear membrane and interact with actin filaments, microtubule filaments (through dynein and kinesin motors), intermediate filaments (through spectrin), centrosomes and cytoplasmic organelles. The number of SUN-domain and KASH-domain proteins increased in evolution.
Many NPOs often use the .org or .us (or the country code top-level domain of their respective country) or .edu top-level domain (TLD) when selecting a domain name to differentiate themselves from more commercial entities, which typically use the .
The domain name arpa is a top-level domain (TLD) in the Domain Name System (DNS) of the Internet. It is used predominantly for the management of technical network infrastructure. Prominent among such functions are the subdomains in-addr.arpa and ip6.
The domain name tokyo is a top-level domain (TLD) for Tokyo in the Domain Name System of the Internet. On November 13, 2013, ICANN and GMO Registry entered into a registry agreement under which GMO Registry operates the TLD.
X-ray crystallography has shown that SLPI has two homologous domains of 53 and 54 amino acids, one of which exhibits anti-protease activity (C-terminal domain). The other domain (N-terminal domain) is not known to have any function.
The MKK7 contains one kinase domain. The direct MKK7:MAPKKK interaction (using the DVD region), facilitates the phosphorylation of MKK7 by MAPKKKs on serine and threonine in a S-K-A-K-T motif in the catalytic domain (kinase domain).
The domain contains about 70 amino acids. The important signature sequence of this domain is (I/L/V)IGXXGXX(I/L/V). All KH domains contain three-stranded β-sheet and three α-helices. There are two subfamilies of this domain.
On 22 July 2010, the Domain Name Commission announced that .nz domain names with macron vowels (ā, ē, ī, ō and ū) would be available from the following week to allow Māori language words to be correctly represented in domain names.
In the Edo period, Kawachi was dotted with tenryō as well as hatamotos. As for daimyōs, there were only two: the Hōjō of Sayama Domain and the Takagi of Tannan Domain. In addition, the Inaba of Yodo Domain had many territories.
The TAg has a CUL7-binding domain, a TP53-binding domain, a Zinc finger, and a Superfamily 3 ATPase/Helicase domain. It has two motifs, one for nuclear localization signal, the other being the LXCXE motif.; InterPro view for P03070.
K+ channel tetramerisation domain is the N-terminal, cytoplasmic tetramerisation domain (T1) of voltage-gated K+ channels. It defines molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. It is distantly related to the BTB/POZ domain .
The royal domain includes a large area, which corresponds to the public domain, and a small area, which is the private domain of the royal family, and inalienable concessions, such as the appanages or large grants that are not hereditary.
Primary Domain Controllers (PDC) have been faithfully recreated on the Samba emulation of Microsoft's SMB client/server system. Samba has the capability to emulate an NT 4.0 domain, as well as modern Active Directory Domain Services on a Linux machine.
An adviser class interpreted the omens of heaven to inform his actions. The nine states Geographically, the state was believed to be square-shaped and centered on the ruler. As described in the Book of Documents, China is a square of 45,000 li with five nested squares spaced at 500 li to create five zones. Beginning at the center, Royal Domain (500 x 500 li), Noble Domain, Domain of Peace-Securing, Domain of Restraint, and Wild Domain.
Factors VII, IX, and X all play key roles in blood coagulation and also share a common domain architecture. The factor IX protein is composed of four protein domains: the Gla domain, two tandem copies of the EGF domain and a C-terminal trypsin-like peptidase domain which carries out the catalytic cleavage. left The N-terminal EGF domain has been shown to at least in part be responsible for binding tissue factor. Wilkinson et al.
Human ASH1L protein is 2969 amino acids long with a molecular weight of 333 kDa. ASH1L has an associated with SET domain (AWS), a SET domain, a post-set domain, a bromodomain, a bromo-adjacent homology domain, and a plant homeodomain finger. Human and Drosophila Ash1 share 66% and 77% similarity in their SET and PHD finger domains, respectively. A bromodomain is not present in Drosophila Ash1. The SET domain is responsible for ASH1L’s histone methyltransferase (HMTase) activity.
The modulation begins with first mapping the information symbols x[k,l] in the delay–Doppler domain to symbols X [n, m] for creating the time-domain signal s(t) which is transmitted over a wireless channel. At the receiver end, the time-domain signal r(t) is mapped to the domain of time- frequency using the Winger transform which is the inverse of Heisenberg transform and then for symbol demodulation uses the delay–Doppler domain.
This entry represents a subdomain of the appendage (ear) domain of beta-adaptin from AP clathrin adaptor complexes. This domain has a three-layer arrangement, alpha-beta- alpha, with a bifurcated antiparallel beta-sheet. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).
The GTD domain does not interact with bezlotoxumab, but appears to interact with B1, which is representative of the entire CROP domain. Bezlotoxumab interacts with either B2 and B3 or the overlapping residues region between the two domains. The B4 fragment does not interact with the specific portion of the CROP domain. Characterization of peptide B1 as full CROP domain of TcdB suggests that the antibody specifically reacts with the B2 region of the CROP domain.
The Beige and Chediak- Higashi (BEACH) domain is one of the most significant domains within this protein. This domain is highly conserved roughly 280 amino acid domain, present in nine different human BEACH domains. It located after the PH_BEACH domain in the sequence. While not much is understood on the exact function of BDCP proteins within the BEACH domain, it is known that they serve many purposes within cellular mechanisms: vesicular transport, apoptosis, membrane dynamics and receptor signaling.
Many General-Purpose Modeling languages already have tool support available in the form of CASE tools. Domain-specific language languages tend to have too small a market size to support the construction of a bespoke CASE tool from scratch. Instead, most tool support for domain-specific language languages is built based on existing domain-specific language frameworks or through domain- specific language environments. A domain-specific language environment may be thought of as a metamodeling tool, i.e.
In vertebrates, Hh signalling has been heavily implicated in the development of cilia. There is striking domain level evolution present in the Hedgehog family of proteins, the N-terminal domain (Hedge) and the C-terminal domain (Hog), that were later spliced together into a single transcriptional unit. The Hog domain contains a sequence called Hint (Hedgehog INTein), which is similar in sequence and function to bacterial and fungal inteins. The Hog domain is present in many eukaryotic branches, i.e.
The bill, if passed, would have allowed the Attorney General to bring an in rem action against the infringing domain name in United States District Court, and seek an order requesting injunctive relief. If granted, such an order would compel the register of the domain name in question to take the following actions: > Upon receipt of such order, the domain name registrar or domain name > registry shall suspend operation of, and may lock, the domain name.
Hell.com is an internet domain which has achieved a degree of notoriety due to its name, and an intentionally mysterious website that existed there from August 1995 to 2009 created by the first registrant of the domain, artist Kenneth Aronson. The domain was sold by Aronson in 2009 to domain investor Rick Latona who put it up for auction several times in 2010, with reserves of up to US$1.5 million. The domain receives thousands of curious visitors daily.
Figure 2. PDE5 domains The PDE5 enzyme has a molecular mass of 200 kDa and its active state is a homodimer. PDE5 consists of monomers and each contains two major functional domains: the regulatory domain (R domain) which is located in the N-terminal portion of the protein and the catalytic domain (C domain) located in the more C-terminal portion of the protein. The R domain contains specific allosteric cGMP binding site that controls the enzymes function.
The Pioneer Domains Program marks the first time ever a domain registry is opening its doors for domains based on the quality of proposals received for any domain name of choice.The Pioneer Domains Program marks the first time ever a domain registry is opening its doors for domains based on the quality of proposals received for any domain name of choice. Similar programs (often referred to as "Founders Program" or "RFP process") were implemented by other domain launches since.
The Unique Domain Authentication Identifier (UDAI) is a case-sensitive, eight- character-long "password" which is a randomly generated unique identifier for every Internet NZ domain name (code ".nz"). The UDAI is made up of letters in both upper and lower case as well as numbers. The UDAI is the password for the domain and can be used to transfer the ownership of the domain. When an Internet domain name is registered, the related UDAI is initially generated.
The DEP domain derives its name from the proteins Dishevelled, Egl-10 and Pleckstrin, each of which contain a variant of this domain. It spans 82 residues and is 343 amino acids from the C-terminus. A SWISS-MODEL predicts two beta sheets and three alpha helices contained within the domain. While its exact function is not known, the DEPDC5 DEP domain has the highest structural similarity to the DEP domain of DVL1 when performing a CBLAST at NCBI.
In 1622, Torii Tadamasa, daimyō of Iwakitaira Domain was transferred to Yamagata Domain, and his place was taken by Naitō Masanaga. Masanaga transferred 20,000 koku of his 70,000 koku domain to his eldest son, Naitō Tadaoki who established a separate household. On Masanaga's death in 1634, Tadaoki inherited Iwakitaira Domain and turned his 20,000 koku holding over to his brother, Naitō Masaharu, who received official confirmation as a daimyō. The marked the start of Izumi Domain.
The protein structure of firefly luciferase consists of two compact domains: the N-terminal domain and the C-terminal domain. The N-terminal domain is composed of two β-sheets in an αβαβα structure and a β barrel. The two β-sheets stack on top of each other, with the β-barrel covering the end of the sheets. The C-terminal domain is connected to the N-terminal domain by a flexible hinge, which can separate the two domains.
In molecular biology, the DmpG-like communication domain is a protein domain found towards the C-terminal region of various aldolase enzymes. It consists of five alpha-helices, four of which form an antiparallel helical bundle that plugs the C terminus of the N-terminal TIM barrel domain. The communication domain is thought to play an important role in the heterodimerisation of the enzyme. This domain heterodimerises with acetaldehyde dehydrogenases to form a bifunctional aldolase-dehydrogenase.
Binding of fadR is specifically inhibited by long chain fatty acyl-CoA compounds. The crystal structure of FadR reveals a two domain dimeric molecule where the N-terminal winged-helix domain binds DNA, and the C-terminal domain binds acyl-CoA. The binding of acyl-CoA to the C-terminal domain results in a conformational change that affects the DNA binding affinity of the N-terminal domain. FadR is a member of the GntR family of bacterial transcription regulators.
Some E3 enzymes also activate the E2 enzymes. E3 enzymes possess one of two domains: the homologous to the E6-AP carboxyl terminus (HECT) domain and the really interesting new gene (RING) domain (or the closely related U-box domain). HECT domain E3s transiently bind ubiquitin in this process (an obligate thioester intermediate is formed with the active-site cysteine of the E3), whereas RING domain E3s catalyse the direct transfer from the E2 enzyme to the substrate.
The NR4A1 gene contains seven exons. An amino terminal transactivation domain is encoded in exon 2, a DNA-binding domain in exons 3 and 4, and dimerisation and ligand-binding domains is exons 5 to 7. The protein has an atypical ligand-binding domain that is unlike the classical ligand-binding domain in most nuclear receptors. The classical domain contains a ligand-receiving pocket and co-activator site, both of which are lacking in the NR4A family.
ICANN Business Constituency (BC) has spent decades trying to make IDN variants work at the second level, and in the last several years at the top level. Domain name variants are domain names recognized in different character encodings, like a single domain presented in traditional Chinese and simplified Chinese. It is an Internationalization and localization problem. Under Domain Name Variants, the different encodings of the domain name (in simplified and traditional Chinese) would resolve to the same host.
A domain auction website provides the technology through which users can list or purchase multiple domains easily and conveniently. Domain parking, once the most efficient method for advertising a domain for sale, allowed a domain owner to post the availability of the domain on a page, hoping someone who was interested in that name would surf through and see it listed for sale. With the development of the domain auction, multiple users can list multiple domains all in the same place, thereby exposing them to a greater number of potential buyers. Sites such as eBay and Sedo have made using auctions very commonplace, and domain auction sites also require little to no technical knowledge to use.
Encoded by the fusA gene on the str operon, EF-G is made up of 704 amino acids that form 5 domains, labeled Domain I through Domain V. Domain I may be referred to as the G-domain or as Domain I(G), since it binds to and hydrolyzes guanosine triphosphate (GTP). Domain I also helps EF-G bind to the ribosome, and contains the N-terminal of the polypeptide chain. Domain IV is important for translocation, as it undergoes a significant conformational change and enters the A site on the 30S ribosomal subunit, pushing the mRNA and tRNA molecules from the A site to the P site. The five domains may be also separated into two super-domains.
In 1635 he was elevated to the ranks of daimyō with revenues of 15,600 koku in Yamakawa Domain in Shimotsuke Province. He relocated to Nishio Domain in Mikawa Province with an increase to 35,000 koku, and then to the more prestigious Hamamatsu Domain (35,000 koku) in Tōtōmi Province. His descendants were relocated several times by shogunate decree, residing successively in 1687 at Tanaka Domain in Suruga Province (50,000 koku), in 1703 at Tanagura Domain in Mutsu Province, and in 1728 at Tatebayashi Domain in Kōzuke Province (50,000 koku). Then, in the period spanning the years 1746 through 1868, this branch of the Ōta clan established itself at Kakegawa Domain (53,000 koku)Papinot, p. 48.
Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains. A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.) An example of a sorting nexin domain structure can be seen here for SNX1: # NTD – N-terminal domain # PX domain # CTD – C-terminal BAR domain Schematic diagram of the 1D structures of a representative sorting nexin, the sorting nexin 1 (SNX1).
On the death of the 2nd daimyō of Morioka Domain, Nanbu Shigenao while under house arrest in Edo, the Tokugawa shogunate intervened in the succession and by order of Shōgun Tokugawa Ietsuna divided the 100,000 koku domain into Morioka Domain (80,000 koku) and Hachinohe Domain (20,000 koku). Hachinohe Domain thus had a somewhat ambiguous status in that it is sometimes regarded as a sub-domain of Morioka Domain although it had not been created by the Nanbu clan. It was also subject to the normal sankin kotai regulations, and was allowed to maintain a castle (which was normally permitted only to independent domains). During official investigations into the untimely deaths of its first two daimyō.
Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is found do not share any region of similarity outside of this domain. ERM proteins are made of three domains, the FERM domain, a central helical domain and a C-terminal tail domain, which binds F-actin. The amino- acid sequence of the FERM domain is highly conserved among ERM proteins and is responsible for membrane association by direct binding to the cytoplasmic domain or tail of integral membrane proteins. ERM proteins are regulated by an intramolecular association of the FERM and C-terminal tail domains that masks their binding sites for other molecules.
The Internet maintains two principal namespaces: the domain name hierarchyRFC 1034, Domain Names—Concepts and Facilities, P. Mockapetris, The Internet Society (November 1987) and the IP address system.RFC 781, Internet Protocol—DARPA Internet Program Protocol Specification, Information Sciences Institute, J. Postel (Ed.), The Internet Society (September 1981) The Domain Name System maintains the domain namespace and provides translation services between these two namespaces. Internet name servers implement the Domain Name System.RFC 1035, Domain Names — Implementation and Specification, P. Mockapetris, The Internet Society (November 1987) The top hierarchy of the Domain Name System is served by the root name servers maintained by delegation by the Internet Corporation for Assigned Names and Numbers (ICANN).
There is a fourth coding domain which is smaller, but exists in all retroviruses. Pol is the domain that encodes the virion protease.
This domain has been found in organisms as diverse as bacteria and archaea, however there are no known orthologs in either organismal domain.
Plots of against are widely used in rock magnetism as a measure of the domain state (single-domain or multidomain) in magnetic minerals.
The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain an ERM domain.
The part of another larger protein with a domain that is very similar to RNase PH is called an RNase PH domain (RPD).
Two types of inhibitors exist targeting either the catalytic core of the RNase domain or the ATP-binding pocket of the kinase domain.
A Fully Qualified Domain Name consists of multiple parts. For example, the english wikipedia domain: `en.wikipedia.org` The `en` is a subdomain. Although `wikipedia.
A Domain-Specific Data Model (DSDM) captures content relevant to a domain of interest and can be used as a basis for USMs.
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. In humans, 4 isoforms of RORα have been identified, which are generated via alternative splicing and promoter usage, and exhibit differential tissue-specific expression. The protein structure of RORα consists of four canonical functional groups: an N-terminal (A/B) domain, a DNA-binding domain containing two zinc fingers, a hinge domain, and a C-terminal ligand-binding domain. Within the ROR family, the DNA-binding domain is highly conserved, and the ligand-binding domain is only moderately conserved.
Kerberos is used as preferred authentication method: In general, joining a client to a Windows domain means enabling Kerberos as default protocol for authentications from that client to services in the Windows domain and all domains with trust relationships to that domain. In contrast, when either client or server or both are not joined to a domain (or not part of the same trusted domain environment), Windows will instead use NTLM for authentication between client and server. Intranet web applications can enforce Kerberos as an authentication method for domain joined clients by using APIs provided under SSPI.
The GSTK1 enzyme is a homodimer and, like all GSTs, it contains a TRX-like domain and a helical domain. However, the GSTK1 is substantially different in its secondary structure compared to the other GSTs. The helical domain has been observed to be placed between the βαβ and ββα motifs of the TRX-like domain, rather than the TRX-like domain and the C-terminal helical domain being connected together by a short linker of alpha-helixes as normally seen in GSTs. Also, the GSTK1 dimer employs a butterfly shape and not a V-shaped crevice like in the other classes.
In September 1995, Dr. Mary B. Kennedy of the California Institute of Technology wrote a letter of correction to Trends in Biomedical Sciences. Earlier that year, another set of scientists had claimed to discover a new protein domain which they called a DHR domain. Dr. Kennedy refuted that her lab had previously described exactly the same domain as a series of “GLGF repeats”. She continued to explain that in order to “better reflect the origin and distribution of the domain,” the new title of the domain would be changed. Thus, the name “PDZ domain” was introduced to the world.
Two important classes of tyrosine kinase in tyrosine phosphorylation are receptor tyrosine kinase and nonreceptor tyrosine kinase. Receptor tyrosine kinases are type I transmembrane proteins possessing an N-terminal extracellular domain, which can bind activating ligands, a single transmembrane domain, and a C-terminal cytoplasmic domain that includes the catalytic domain. Nonreceptor tyrosine kinases lack a transmembrane domain. Most are soluble intracellular proteins, but a subset associate with membranes via a membrane-targeting posttranslational modification, such as an N-terminal myristoyl group, and can act as the catalytic subunit for receptors that lack their own catalytic domain.
Noise-domain reflectometry is a type of reflectometry where the reflectometer exploits existing data signals on wiring and does not have to generate any signals itself. Noise-domain reflectometry, like time-domain and spread- spectrum time domain reflectometers, is most often used in identifying the location of wire faults in electrical lines. Time-domain reflectometers work by generating a signal and then sending that signal down the wireline and examining the reflected signal. Noise-domain reflectometers (NDRs) provide the benefit of locating wire faults without introducing an external signal because the NDR examines the existing signals on the line to identify wire faults.
88 Then in the fall of 1686, the domain government raised taxes to an exorbitant level. (The domain lord who was away from home at the time was obviously not informed of the tax rise.) The reason for this tax rise was that the domain government needed more money. The domain lord of Matsumoto was a fudai daimyō, who was obligated to perform many duties, and therefore had to spend a lot of money. The domain lords of neighboring Takatō and Takashima were not under such pressure to perform such duties, even though they used to be a part of the Matsumoto Domain.
The Fourier transform converts the function's time-domain representation, shown in red, to the function's frequency-domain representation, shown in blue. The component frequencies, spread across the frequency spectrum, are represented as peaks in the frequency domain. In physics, electronics, control systems engineering, and statistics, the frequency domain refers to the analysis of mathematical functions or signals with respect to frequency, rather than time. Put simply, a time-domain graph shows how a signal changes over time, whereas a frequency-domain graph shows how much of the signal lies within each given frequency band over a range of frequencies.
Takasato was born in 1746 as the son Tōdō Takahora, a 7000-koku hatamoto, who was adopted to become the 5th daimyo of Hisai Domain, a subsidiary domain of Tsu Domain, in 1728, and subsequently the 8th daimyō of Tsu Domain from 1735. In 1762, Takasato was made daimyo of Hisai. However, on the death of his father in 1770, he turned Hisai over to a younger son of Tōdō Takatoyo, and took on the reign of Tsu Domain itself. The domain suffered from severe financial problems during his rule, and he attempted a series of reforms, including encouragement of new industries.
After the final Tokugawa Shōgun, Tokugawa Yoshinobu, surrendered his title to Emperor Meiji, he relocated from Edo to Sumpu, with the provinces of Suruga, Izu and Mikawa assigned as his personal domains. Tanaka Domain was included within the area of the new Shizuoka Domain. Thus, in September 1868, Tanaka Domain officially ceased to exist. The final daimyō of Tanaka Domain, Honda Masamori, received the new (and short-lived) domain of Nagao Domain in Awa province in exchange for his previous holdings, and took steps to relocate to that location before the abolition of the han system in 1871.
The Ski2 like helicase Mtr4p was discovered during the screening of heat resistant mutants that gather Poly(A) RNA in the nucleus and is mainly involved in unwinding activity. Mtr4p (also called as Dob1p) is an SF2 helicase and belongs to DExH-box RNA helicases family consisting of two RecA like domains. It also consists of WH domain (Winged Helix domain), an Arch domain (also called as stalk and KOW domain [Kyprides, Ouzounis, Woese domain]) and helical bundle domain. The packing of the WH and helical bundle domains on surface of the helicase core results in the formation of a channel for ssRNA.
The structure of the Salmonella typhimurium chemotaxis receptor methyltransferase CheR, bound to S-adenosylhomocysteine, has been determined to a resolution of 2.0 Angstrom. The structure reveals CheR to be a two-domain protein, with a smaller N-terminal helical domain linked via a single polypeptide connection to a larger C-terminal alpha/beta domain. The C-terminal domain has the characteristics of a nucleotide-binding fold, with an insertion of a small anti-parallel beta-sheet subdomain. The S-adenosylhomocysteine-binding site is formed mainly by the large domain, with contributions from residues within the N-terminal domain and the linker region.
However, after the defection of Kubota Domain to the imperial side, and the defeat of the Northern Alliance at the Battle of Hokuetsu and the Battle of Aizu, Shōnai Domain surrendered without a fight in December. Sakai Tadazumi turned the domain over to his son, Sakai Tadamichi and the domain was reduced to 120,000 koku. However, in June 1869, the Sakai were ordered to relocate to Iwakitaira Domain. This move was strongly protested by the people of the domain, who raised 300,000 ryō as payment to the Meiji government, and obtained the support of Saigō Takamori to have the order rescinded.
Domain name resolvers determine the domain name servers responsible for the domain name in question by a sequence of queries starting with the right-most (top-level) domain label. A DNS resolver that implements the iterative approach mandated by RFC 1034; in this case, the resolver consults three name servers to resolve the fully qualified domain name "www.wikipedia.org". For proper operation of its domain name resolver, a network host is configured with an initial cache (hints) of the known addresses of the root name servers. The hints are updated periodically by an administrator by retrieving a dataset from a reliable source.
Blockchain domain names are another use of blockchain on the rise. Unlike regular domain names, blockchain domain names are entirely an asset of the domain owner and can only be controlled by the owner through a private key. Blockchain domains pave the way to having sites that are more resistant to censorship and thus enable freedom of speech as there are no authorities or individuals that can intervene on controlling a domain except the private key holder. Again, they are a better option to replace the traditional cryptocurrency wallet addresses as one can easily memorize the domain and use it for receiving payments.
He was subsequently transferred to Tanaka Domain in Suruga Province and Sanuki Domain reverted to tenryō territory directly under the control of the Tokugawa shogunate. In January 1639, the domain was revived for Matsudaira Katsutaka, a former jisha-bugyō, whose holdings had reached 15,000 koku, qualifying for the status of daimyō. However, the Matsudaira clan was dispossessed from Sanuki under the tenure of his son, Matsudaira Shigeharu, for mismanagement, and Sanuki Domain again lapsed to tenryō status. In May 1710, the domain was reestablished as a 16,000 koku holding for Abe Masatane, formerly daimyō of Kariya Domain in Mikawa Province.
Humans occasionally produce single domain antibodies by the random creation of a stop codon in the light chain. Mitchell Ho and Dimiter Dimitrov at the National Cancer Institute generated human single-domain antibodies targeting various tumor antigens including mesothelin, GPC2 and GPC3 from an engineered human VH domain phage display library. The human single-domain antibodies have been used to create immunotoxins (HN3-PE38, HN3-mPE24, HN3-T20) and chimeric antigen receptor (CAR) T cells for treating cancer. Blocking the Wnt binding domain on GPC3 by the HN3 human single-domain antibody inhibits Wnt activation in liver cancer cells.
In mathematics, a GCD domain is an integral domain R with the property that any two elements have a greatest common divisor (GCD); i.e., there is a unique minimal principal ideal containing the ideal generated by two given elements. Equivalently, any two elements of R have a least common multiple (LCM). A GCD domain generalizes a unique factorization domain (UFD) to a non-Noetherian setting in the following sense: an integral domain is a UFD if and only if it is a GCD domain satisfying the ascending chain condition on principal ideals (and in particular if it is Noetherian).
Tissue factor belongs to the cytokine receptor protein superfamily and consists of three domains: # an extracellular domain, which consists of two fibronectin type III modules whose hydrophobic cores merge in the domain-domain interface. This serves as a (probably rigid) template for factor VIIa binding. # a transmembrane domain. # a cytosolic domain of 21 amino acids length inside the cell which is involved in the signaling function of TF. Note that one of factor VIIa's domains, GLA domain, binds in the presence of calcium to negatively charged phospholipids, and this binding greatly enhances factor VIIa binding to tissue factor.
Human as well murine STAT4 genes lie next to STAT1 gene locus suggesting that the genes arose by gene duplication. STAT proteins have several functional domains, including an N-terminal interaction domain, a central DNA-binding domain, an SH2 domain, and the C-terminal transactivation domain. The length of the protein is 748 amino acids, and the molecular weight is 85 941 Dalton .
PRRs were first discovered in plants. Since that time many plant PRRs have been predicted by genomic analysis (370 in rice; 47 in Arabidopsis). Unlike animal PRRs, which associated with intracellular kinases via adaptor proteins (see non-RD kinases below), plant PRRs are composed of an extracellular domain, transmembrane domain, juxtamembrane domain and intracellular kinase domain as part of a single protein.
The rod domain connects to the head domain. The head domain 84 amino acids with many arginine, serine, and aromatic residues is important in filament assembly and dimer-dimer interactions. The tail domain is responsible for the integration of filaments and interaction with proteins and organelles. Desmin is only expressed in vertebrates, however homologous proteins are found in many organisms.
KaiA Three functional domains: 1) N-terminal domain (amplitude- amplifier) 2) Central period-adjuster domain 3) C-terminal clock-oscillator domain The C-terminal domain assists in dimer formation, thus allowing KaiA to bind to KaiC. This further enhances KaiC phosphorylation. (see functions below) Located at the center of the concave portion of KaiA is residue His270, which is essential to KaiA function.
A Link domain or Link module, also known as Xlink domain (X for extracellular), is a protein domain that binds to hyaluronic acid. It is important in blood cell migration and apoptosis. The link domain is found in some extracellular proteins in vertebrates such as the hyalectans. It appears to be involved in extracellular matrix assembly and stability, cell adhesion, and migration.
ODIN is a member of the ankyrin repeat and sterile alpha motif domain-containing (ANKS) family and contains 6 ankyrin repeats, 1 phosphotyrosine binding (PTD) domain, and 2 tandem sterile alpha motif (SAM) domains. The first SAM domain binds to the SAM domain of the EphA2 receptor by adopting a mid-loop/end-helix conformation and may regulate EphA2 endocytosis.
In mathematics, and more specifically in algebra, a domain is a nonzero ring in which implies or .Lam (2001), p. 3 (Sometimes such a ring is said to "have the zero-product property".) Equivalently, a domain is a ring in which 0 is the only left zero divisor (or equivalently, the only right zero divisor). A commutative domain is called an integral domain.
CDMI supports the concept of a domain, similar in concept to a domain in the Windows Active Directory model. Users and groups created in a domain share a common administrative database and are known to each other on a "first name" basis, i.e. without reference to any other domain or system. Domains also function as containers for usage and billing summary data.
The domain name .bg is the country code top-level domain (ccTLD) in the Domain Name System of the Internet for Bulgaria. It is currently operated by Register.BG. The domain name registration guideline impose the following restrictions: Domains can be registered by companies or citizens of the European Union, or foreign companies that have registered branches or commercial representatives in Bulgaria.
Domain-specific modeling often also includes the idea of code generation: automating the creation of executable source code directly from the domain- specific language models. Being free from the manual creation and maintenance of source code means domain-specific language can significantly improve developer productivity.Kelly, S. and Tolvanen, J.-P., (2008) Domain-Specific Modeling: Enabling Full Code Generation, John Wiley & Sons, New Jersey.
A business domain in object-oriented programming is the set of classes that represent objects in the business model being implemented. The business domain is distinguishable from the business model in that the business model is an understanding and explanation of information and behaviors in the problem domain while the business domain is an implementation of that model in a specific programming language.
The was a feudal domain in Mutsu Province of Japan (present-day Mizusawa-ward, Ōshū, Iwate) during the Edo period. It was a subdomain (支藩) of the Sendai Domain. Sometimes it was suggested that the domain be called "Naka-Tsuyama han" (中津山藩). The domain as a separate entity was ultimately short-lived, eventually being reabsorbed into Sendai territory.
Taq polymerase exonuclease is a domain found in the amino-terminal of Taq DNA polymerase I (thermostable). It assumes a ribonuclease H-like motif. The domain confers 5'-3' exonuclease activity to the polymerase. Unlike the same domain in E. coli, which would degrade primers and must be removed by digestion for PCR use, this domain is not said to degrade the primer.
The WPP domain is a protein domain thought to be exclusively found in plants, first identified in 2000. The domain is about 90 amino acid residues long. The domain is known to direct RanGAP to the nuclear envelope. Non-RanGAP nuclear envelope proteins are also known to encode WPP domains, such as MFP1 attachment factor 1 (MAF1), WPP1 and WPP2.
The C1q domain is a conserved protein domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system. C1q comprises 6 A, 6 B and 6 C chains. These share the same topology, each possessing a small, globular N-terminal domain, a collagen-like Gly/Pro-rich central region, and a conserved C-terminal region, the C1q domain.
The core domains of the PAK family include a kinase domain in the C-terminal region, a p21-binding domain (PBD), and an auto-inhibitory domain (AID) in group I PAKs. Group I PAKs exist in an inactive, closed homodimer conformation wherein AID of one molecule binds to the kinase domain of another molecule, and activated in both GTPase-dependent and -independent manners.
STING is a 378 amino acid protein. Its N-terminal region (residues 1-154) contains four trans-membrane domains. Its C-terminal domain contains the dimerization domain, the cyclic dinucleotide interaction domain, as well as a domain responsible for interacting and activating TBK1. Upon binding of 2’-3’ cGAMP, STING undergoes a significant conformational change (approximately 20 Angstrom inward rotation) that encloses cGAMP.
Physically, the Active Directory information is held on one or more peer domain controllers, replacing the NT PDC/BDC model. Each DC has a copy of the Active Directory. Servers joined to Active Directory that are not domain controllers are called Member Servers. A subset of objects in the domain partition replicate to domain controllers that are configured as global catalogs.
Like the other four PRR proteins found in Arabidopsis, TOC1 is located in the nucleus and employs a pseudo-receiver (PR) domain in the N-terminus and a CONSTANS, CONSTANS-LIKE, and TOC1 (CCT) domain at the C-terminus. Through its CCT domain, TOC1 is able to directly bind DNA, and the PR domain is responsible for transcriptional repression activity.
Concepts used for describing specific problems include: phenomena (of various kinds, including events), problem context, problem domain, solution domain (aka the machine), shared phenomena (which exist in domain interfaces), domain requirements (which exist in the problem domains) and specifications (which exist at the problem domain:machine interface). The graphical tools for describing problems are the context diagram and the problem diagram.
Katsuyama is part of ancient Echizen Province. During the Edo period, the area was divided between the holdings of Echizen-Katsuyama Domain, Fukui Domain, Ōno Domain, and Gujō Domain. Following the Meiji restoration, it was organised into part of Ōno District in Fukui Prefecture. With the establishment of the modern municipalities system on April 1, 1889, the town of Katsuyama was established.
These ads are typically driven by pay per click search engines like Google or Yahoo, but ads can sometimes be placed directly on targeted domain names through a domain lease or by making contact with the registrant of a domain name that describes a product. Domain name registrants are generally easy to identify through WHOIS records that are publicly available at registrar websites.
All three SHC1 proteins share the same domain arrangement consisting of an N-terminal phosphotyrosine- binding(PTB) domain and a C-terminal Src-homology2(SH2) domain. Both of the domains for the three proteins can bind to tyrosine-phosphorylated proteins but they are different in their phosphopeptide-binding specificities. P66SHC is characterized by having an additional N-terminal CH2 domain.
So far there are six SUMO proteases in humans that have been designated SENP1-3 and SENP5-7 (sentrin/SUMO-specific protease).1 The six proteases possess a conserved C-terminal domain which are variable in size, and with a distinct N-terminal domain between them. The C-terminal domain shows catalytic activity and N-terminal domain regulates cell localization and substrate specificity.
In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). Vitamin D-binding protein (DBP)(also referred to as Gc-globulin) is synthesized primarily in the liver. This entry outlines the domain III of DBP. Domain III (amino acid 379–458) is G-actin binding region located in the C-terminal.
In June 2008 the ICANN approved a document that foresees the introduction of high-level domain names in Cyrillic and other national non-Latin alphabets.Market operator: Cyrillic .укр domain unlikely to be registered, Kyiv Post (November 18, 2009) On November 17, 2009 Ukraine initiated an application to ICANN for assignment of the Cyrillic top-level domain name 'укр'.Ukraine to register domain '.
A domain hack is a domain name that suggests a word, phrase, or name when concatenating two or more adjacent levels of that domain. For example, and , using the fictitious country-code domains .ds and .le, suggest the words birds and example respectively.
This region is usually very thermodynamically stable and occurs only in the phospholipid membrane between cells. The intracellular domain is the serine/threonine kinase domain. In this domain, phosphorylation catalyzes a protein kinase cascade leading to a response.Shiu, S.H., and Bleecker, A.B. (2001).
Based on sequence homology, mammalian Gapex-5 has been shown to have an amino- terminal Ras GAP domain, a central polyproline (SH3 binding) region and a carboxy-terminal Rab GEF domain. The RabGEF domain has been suggested to activate Rab5 and Rab31.
Domain of Unknown Function 4098 is domain found in all FAM185A orthologs, as well as in some other non-orthologous species. DUF4098 is a c-terminal repetitive bacterial domain and is part of the pfam13345 family of domains and the superfamily cl16248.
Open letter (in Bulgarian) The domain has been enabled with Domain Name System Security Extensions (DNSSEC) since October 2007. On September 5, 2009, Register.bg started accepting second- and third-level domain names in Cyrillic with letters found in the Bulgarian language only.
In January 2008, Network Solutions was accused of this practice when the company began reserving all domain names searched on their website for five days,Domain Registrar Network Solutions Front Running On Whois Searches a practice known as domain name front running.
Site of Koga Castle, administrative headquarters of Koga Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Shimōsa Province, Honshū. The domain was centered at Koga Castle,"Koga Castle" at JapaneseCastleExplorer.com; retrieved 2016-12-2.
Tap can form a multimeric complex with itself and with other members of the NXF family. Three functional domains of Tap have been well characterized: the RNA-binding domain, the Nuclear Transport Factor 2 (NTF2)-like domain, and the ubiquitin-associated (UBA) domain.
Lambda calculus is a consistent theory in its own domain. However, it is not consistent to add the lambda abstraction definition to general mathematics. Lambda terms describe values from the lambda calculus domain. Each lambda term has a value in that domain.
There is currently no standard for determining the responsible WHOIS server for a DNS domain, though a number of methods are in common use for top-level domains (TLDs). Some WHOIS lookups require searching the procuring domain registrar to display domain owner details.
Kawagoe Castle daimyō residence, administrative headquarters of Kawagoe Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Musashi Province, Honshū. The domain was centered at Kawagoe Castle,"Kawagoe Castle" at JapaneseCastleExplorer.com; retrieved 2013-7-2.
The symmetry classification of magnetic domain walls contains 64 magnetic point groups. Schematic representation of domain wall unpinning Symmetry-based predictions of the structure of the multiferroic domain walls have been proven using phenomenology coupling via magnetization and/or polarization spatial derivatives (flexomagnetoelectric).
Sufu is actually protein that contains two domains. In eukaryotic Sufu, an additional domain is found at the C terminus of the protein. This protein domain also binds to the C-terminal domain of the Gli/Ci transcription factors, inhibiting their activity.
NLRP protein structure has a N-terminal PYD domain followed by NACHT domain and several leucine-rich repeats (LRR). These PYD domains can interact with other PYD domains to allow for interaction between NRLP and other proteins also containing a PYD domain.
Originally, the top-level domain space was organized into three main groups: Countries, Categories, and Multiorganizations. An additional temporary group consisted of only the initial DNS domain, arpa, and was intended for transitional purposes toward the stabilization of the domain name system.
A partially qualified domain name does not include all labels to the DNS root. Such a name is also known as a relative domain name. Relative domain names are often simply hostnames, i.e. the left-most label in a fully qualified name.
When domains do combine, the N- to C- terminal domain order (the "domain architecture") is typically well conserved. Additionally, the number of domain combinations seen in nature is small compared to the number of possibilities, suggesting that selection acts on all combinations.
A commutative principal ideal ring which is also an integral domain is said to be a principal ideal domain (PID). In this article the focus is on the more general concept of a principal ideal ring which is not necessarily a domain.
In 1681, he was called upon to send his forces to Takada Domain in Echigo Province to enforce the attainder of that domain. He died in 1706 at the age of 58. His wife was a daughter of Nakagawa Hisakiyo of Oka Domain.
On 16-Sep-2012 aeDA made an announcement on reaching the 100,000 registration mark in domain names. During Gitex2008, .aeDA domain name counter showed over 90,000 domain names currently held in the registry, making it the largest ccTLD registry in the Arab region.
For this reason the country continued to use the Soviet domain. In 1994 the .ru domain was created, which is supposed to eventually replace the .su domain (domains for the republics other than Russia were created at different times in the mid-nineties).
In this view, expressions involving psychological forces reflect an extension of the category of force dynamics from the physical domain to the psychological domain.
The N-terminal domain of restriction endonuclease EcoRII; the C-terminal domain of restriction endonuclease BfiI possess a similar DNA-binding pseudobarrel protein fold.
Satake Yoshisato Viscount , was the 9th and final daimyō of Iwasaki Domain (also known as Nitta Domain) in Dewa Province (present day Yuzawa, Akita).
This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.
Matsuyama Castle, seat of the domain The was a Japanese domain of the Edo period, with its holdings centered in modern-day Matsuyama, Ehime.
The domain came to an end with its conquest by forces of the Chōshū Domain and its subsequent absorption of Hamada into Chōshū territory.
The Maheno Rugby Football Club play their home games at the Maheno Domain. The Maheno domain is situated along Kakanui Valley road, in Maheno.
The top-level domain io has existed since 1997. The first subdomain was registered in 1998, when Levi Strauss & Co. registered the domain levi.io.
The primitive cell is a fundamental domain with respect to translational symmetry only. In the case of additional symmetries a fundamental domain is smaller.
The Beast's Domain is a multiplayer, interactive, real-time, Rogue-like ANSI adventure game. The Beast's Domain can handle up to 250 simultaneous players.
One fragment contains the C-terminal olfactomedin-like domain (35 kDa), and the other contains the N-terminal leucine zipper-like domain (20 kDa).
For example, a large residual may be expected in the middle of the domain, but considered an outlier at the end of the domain.
The www subdomain contains the directories for the webpages. Independent authentication for each domain provides access control over the various levels of the domain.
GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.
The domain now hosts a customized e-mail service, made possible by its acquisition of Mailbank and its long list of surname domain names.
The fork head domain is a type of protein domain that is often found in transcription factors and whose purpose is to bind DNA.
The domain name .укр (romanized as .ukr; abbreviation of , tr. Ukrayina) is an approved internationalized country code top-level domain (IDN ccTLD) for Ukraine.
A Per-Arnt-Sim (PAS) domain is a protein domain found in all kingdoms of life. Generally, the PAS domain acts as a molecular sensor, whereby small molecules and other proteins associate via binding of the PAS domain. Due to this sensing capability, the PAS domain has been shown as the key structural motif involved in protein-protein interactions of the circadian clock, and it is also a common motif found in signaling proteins, where it functions as a signaling sensor.
Another feature of Domain 1 is the presence of a carbohydrate binding site that direct the enzyme to bind to extracellular carbohydrates. Domain 2 (residues 156-552) contains the copper binding site. The β-strands in Domain 2 are organized as a seven-fold propeller, and each of the seven structural units is a subdomain consisting of four antiparallel β-strands. Domain 3 (residues 553-639) consists of seven anti-parallel β-strands and forms a “cap” over Domain 2.
Humans have three VAPs: VAPA, VAPB and MOSPD2. All of these share a conserved major sperm protein domain in the cytoplasm anchored to the endoplasmic reticulum membrane by a largely unstructured linker leading to a transmembrane domain. MOSPD2 additionally at its amino- terminus has a lipid transfer domain in the CRAL/TRIO domain family. The main yeast homolog is Scs2p, which has the same domain architecture as VAPA and VAPB, and is also an integral membrane protein of the endoplasmic reticulum.
WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene. The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase- associated protein by a conserved region: XPPXY motif.
Zinc finger protein chimera are chimeric proteins composed of a DNA-binding zinc finger protein domain and another domain through which the protein exerts its effect. The effector domain may be a transcriptional activator (A) or repressor (R), a methylation domain (M) or a nuclease (N). Modification of the endogenous DNA-binding zinc finger domain is the basis of the most advanced field in construction of gene-specific artificial transcription factors. Linking together six ZFPs produces a target-site of 18-19 bp.
Angiopoietin protein structure. It consists of the N-terminus super cluster domain, the linker region, the central coiled domain, and the binding site at the C terminus. Structurally, angiopoietins have an N-terminal super clustering domain, a central coiled domain, a linker region, and a C-terminal fibrinogen-related domain responsible for the binding between the ligand and receptor. Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 amino acid polypeptide.
WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene. The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase- associated protein by its PY motifs.
The catalytic residues of the cytoplasmic PNGase is known to reside in a domain called transglutaminase domain. NGLY1, when compared with the yeast orthologues, possesses extended N-terminal and C-terminal sequences in addition to the transglutaminase domain. Among the additional domains found in NGLY1, the PUB (PNGase- and ubiquitin-related) domain was first identified through a bioinformatics analysis. While it was initially hypothesized that it might serve as a protein-protein interaction domain, experimental evidence supporting this hypothesis is now accumulating.
A pharmacophore model consisting of four hydrogen bond donor sites and three hydrogen bond acceptor sites was proposed for this domain. Unlike the proteinase domain, the ancillary domain varies by ADAMTS protein and includes any number of thrombospondin (TSP) type 1 motifs, one cysteine-rich and spacer domain, and other domains specific to certain ADAMTS proteins. ADAMTS7 in particular possesses 8 TSP type 1 motifs which, together with its spacer domain, participate in the protein’s tight interaction with the extracellular matrix.
MIA3 is a member of the MIA/OTOR family. The full-length protein spans 1,907 amino acids and localizes to the ER exit sites. It contains an N-terminal, SH3-like domain, two predicted transmembrane domains, a coiled-coiled domain, and a C-terminal, proline-rich domain. The SH3-like domain faces the ER lumen, where it can bind cargo for COPII carrier biogenesis, while the proline-rich domain faces the cytoplasm, where it can bind the COPII components Sec23/24.
Structurally the protein consists of an acidic N-terminal domain of about 90 kDa separated from a basic C-terminal domain of about 25 kDa by a proline-rich region of about 50 residues. The central part of the N-terminal domain consists of a variable number (3 in vertebrates, 2 in Caenorhabditis elegans) of repeats of a 110 amino acids domain. Alpha-catenins are evolutionary related to vinculin. Catenins are proteins that associate with the cytoplasmic domain of a variety of cadherins.
Summary of features on the Cxorf26 protein sequence, with conserved polysaccharide biosynthesis domain highlighted in green CXorf26 was found to have conserved domain known as DUF757 within its sequence. NCBI BLAST Assembled RefSeq Genomes The conserved domain spans a majority of the protein sequence, from amino acids 39-159. Conservation of the domain is strong throughout all homologs compared, including mammals, invertebrates such as insects, and even sponges. The yeast homolog, YPL225W, shows 42.4% identity and 62% similarity in this domain.
Often all domain controllers are also global catalog servers. If this is not the case, the Infrastructure Master role must not be housed on a domain controller which also houses a copy of the global catalog in a multi-domain forest, as the combination of these two roles on the same host will cause unexpected (and potentially damaging) behaviour in a multi-domain environment. However, The Domain Naming Master role should be housed on a DC which is also a GC.
Domain name speculation has evolved with the expansion of the domain name system. Domain names were registered primarily for business purposes. In the 1990s, much of the ccTLD landscape had yet to appear, and the growing public awareness of the COM TLD was gathering momentum owing to the growth of the Dot-com bubble. This inevitably attracted the attention of those who saw potential value in domain names, and by this time many of the most valuable generic domain names, such as sex.
Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell Science 112 (1999) 3591–3601. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39–129 residues in length, a related Ser/Thr protein kinase domain and a short C-terminal domain containing 15–20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein–protein interactions.
The structure of NS5B is similar to other viral polynucleotide polymerases and is made up of three subdomains. The structure resembles a right hand with a palm domain that acts as the foundation for the active site, a finger domain, and a thumb domain. The thumb and finger domains encircle the active site of the enzyme. The finger domain has two loops, named Λ1 and Λ2, that reach over and interact with the top of the thumb domain to enclose the active site.
CI- OFDM Transmitter and Receiver Since CI coding can shape the time-domain characteristics of the transmitted waveform, it can be used to synthesize various waveforms, such as direct-sequence spread spectrum and frequency shift key [4] signals. The advantage is that the receiver can select time-domain or frequency-domain equalization based on how much scattering occurs in the transmission channel. For rich scattering environments, frequency-domain equalization using FFTs requires less computation than conventional time- domain equalization and performs substantially better.
The Arabic domain name ' (meaning "Egypt", romanized as masr' or misrTwo New Licenses for (.masr) Domain Name Registration to Be Launched ) is the internationalized country code top-level domain (IDN ccTLD) in the Domain Name System (DNS) of the Internet for Egypt.First IDN ccTLDs available, ICANN announcement, 2010-05-05 'Historic' day as first non-latin web addresses go live, BBC, 6 May 2010. Its ASCII DNS name is `xn--wgbh1c`, obtained by the Internationalizing Domain Names in Applications (IDNA) transcription method.
Hisamichi, the heir of Hisahide, had a son named Hikobe’e Ichimaru or Kazumaru (彦兵衛一丸). He moved down to Hakata, Chikuzen Province, opened a pawnshop and became a wealthy merchant. Hikobe's descendant became retainers of the Saga Domain. They include Matsunaga Munetomo (松永宗伴) as a retainer of the Saga Domain and Matsunaga Shouemon (松永所右衛門) as a retainer of Kashima Domain which was a branched domain of the Saga Domain.
This "reservation" can be removed by anyone immediately by contacting Network Solutions customer service hotline, or it will automatically unreserve within four days, allowing the domain to be freely registered anywhere. Also, visitors searching for domain names on their website allow the reservation when they click "OK" on the Reservation Confirmation dialog box. Clicking "Cancel" will prevent the domain name from being reserved. On January 8, 2008, Domain Name Wire published a story alleging that Network Solutions practices domain name front running.
ROCK is a downstream effector molecule of the Rho GTPase Rho that increases ROCK kinase activity when bound to it. Autoinhibition ROCK activity is regulated by the disruption of an intramolecular autoinhibition. In general, the structure of ROCK proteins consists of an N-terminal kinase domain, a coiled-coiled region and a PH domain containing a cystein-rich domain (CRD) at the C-terminal. A Rho- binding domain (RBD) is located in close proximity just in front of the PH domain.
Ca2+-binding to the C2B domain confers synaptotagmin dimerization involved in the fusion step of synaptic vesicles by Ca2+-dependent self-clustering via the C2B domain. Ca2+-independent is the interaction between the C2B domain and SNAP-25, and between the C2B domain and the "synprint" (synaptic protein interaction) motif of the pore-forming subunit of voltage-gated calcium channels. The C2B domain regulates also the recycling step of synaptic vesicles by binding to the clathrin assembly protein, AP-2.
Kubota-Shinden Domain was reabsorbed back into Kubota Domain in 1732, but Iwasaki Domain lasted until the Meiji restoration as a cadet house of the Satake clan. In 1703, Satake Yoshizumi died at Yokote Castle. It was said that he often forgot the eat or sleep, and sometimes vomited blood, as he worked tirelessly for the benefit of the domain. Satake Yoshizumi was wed to Tsuruhime, the daughter of Matsudaira Naomasa of Matsue Domain, but his only son, Satake Yoshimitsu died in 1699.
IQGAP1 has 5 well-known domains separated by other amino acids. IQGAP1 protein Starting at the N-terminus (or front of the protein), IQGAP1 contains a calponin homology domain (CHD), which mediates actin-binding and binds calponin. The WW, or poly-proline protein- protein domain, so named because of two functionally conserved tryptophans, W, is a protein-protein interaction domain that associates with proline-rich regions of other proteins. The WW domain is followed by 4 IQ motifs which form an IQ domain.
Other DD- containing proteins, such as ankyrin, MyD88 and pelle, are probably not directly involved in cell death signalling. DD-containing proteins also have links to innate immunity, communicating with Toll-like receptors through bipartite adapter proteins such as MyD88. The DD superfamily is one of the largest and most studied domain superfamilies. It currently comprises four subfamilies, the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily and the pyrin domain (PYD) subfamily.
The process is conducted by first choosing the domain in which data is presented. The domains used include time domain, frequency domain, modal domain, and time-frequency domain. The second step is to determine which parts of the initial models are thought to have been modeled incorrectly. The third task is to formulate a function which has the parameters that are expected to be design variables, and which represents the distance between the measured data and the finite element model predicted data.
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.
The MIT domain is responsible for the interaction of Vps4 with the MIM domain of Vps2. The AAA-ATPase domain hydrolyzes ATP to power disassembly of the ESCRT-III complex. This “stripping” of ESCRT-III allows all associated subunits to be recycled for further use. Vta1 is a dimeric protein containing one VSL domain (so named because it is found in the proteins Vps4, SBP1, and LIP5), which enables binding to Vps4, and a MIT domain for associating with ESCRT-III subunit Vps60.
Domain organization of SWI/SNF: a subfamily within the ATP-Dependent chromatin remodeling complexes Electron microscopy studies of SWI/SNF and RSC (SWI/SNF-B) reveal large, lobed 1.1-1.3 MDa structures. These structures resemble RecA and cover both sides of a conserved section of the ATPase domain. The domain also contains a separate domain, HSA, that is capable of binding actin, and resides on the N-terminus. The bromo domain present is responsible for recognizing and binding lysines that have been acetylated.
The ATP hydrolyzing activity is indispensable for the p97/CDC48 functions. The two ATPase domains of p97 (D1 and D2) are not equivalent because the D2 domain displays higher ATPase activity than the D1 domain in wild-type protein. Nevertheless, their activities are dependent of each other. For example, nucleotide binding to the D1 domain is required for ATP binding to the D2 domain and nucleotide binding and hydrolysis in D2 is required for the D1 domain to hydrolyze ATP.
A domain reputation is a sending reputation for a specific domain name. A domain may lose its reputation if the emails are being sent in large quantity at once and with too high frequency. The recipient's email server may consider such behavior as spamming and blocklist the domain used for sending emails. A domain may be also blocklisted if spam filters detect spam words in the subject line or the email content or an attempt to use other spamming techniques.
A fully qualified domain name consists of a list of domain labels representing the hierarchy from the lowest relevant level in the DNS to the top-level domain (TLD). The domain labels are concatenated using the full stop “” character (dot or period) as a separator between labels. The DNS root is unnamed, expressed as the empty label terminated by the dot. This is most notable in DNS zone files in which a fully qualified domain name must be specified with a trailing dot.
All K+ channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K+ selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+ across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore.
In 1660, Daishōji Domain was able to exchange this remote exclave for 6 villages in Nomi District, adjacent to Enuma District. Under its third daimyō, Maeda Toshinao, new riceland development allowed the domain to create its own subsidiary 10,000 koku domain, , for Toshinao's younger brother Maeda Toshimasa. However, after Toshimasa killed the daimyō of Yanagimoto Domain, Oda Hidechika in a duel, the domain was dissolved. Under its 9th daimyō, Maeda Toshikore, the domain's kokudaka was increased from 70,000 to 100,000 koku.
Domain names serve to identify Internet resources, such as computers, networks, and services, with a text-based label that is easier to memorize than the numerical addresses used in the Internet protocols. A domain name may represent entire collections of such resources or individual instances. Individual Internet host computers use domain names as host identifiers, also called hostnames. The term hostname is also used for the leaf labels in the domain name system, usually without further subordinate domain name space.
AdvFS uses a relatively advanced concept of a storage pool (called a file domain) and of logical file systems (called file sets). A file domain is composed of any number of block devices, which could be partitions, LVM or LSM devices. A file set is a logical file system created in a single file domain. Administrators can add or remove volumes from an active file domain, providing that there is enough space on the remaining file domain, in case of removal.
This map shows the major domains of the Superior Craton. NSS: Northern Superior Superterrane; OSD Oxford-Stull Terrane; NCT: North Caribou Terrane; ERT: English River Domain; WRT: Winnipeg River Domain; WWT: Western Wabigoon Terrane; EWT: Eastern Wabigoon Terrane; MT: Marmion Terrane; QT: Quetico Terrane; WT: Wawa Terrane; MRVT: Minnesota River Valley Terrane; KU: Kapuskasing Uplift; AT: Abitibi Terrane; PT: Pontiac Terrane; OcS: Opatica Subprovince; AC: Ashuanipi Complex; OnS: Opinaca Subprovince; LG: La Grande Subprovince; BS: Bienville Subprovince; I: Inukjuak Domain; II Tikkerutuk Domain; IV: Lake Minto Domain; V: Goudalie Domain: VI Utsalik Domain; VII: Douglas Harbour Domain The Superior Province can be divided into three parts. The first part is the northwestern region characterized by high- grade gneiss, such as Minto and Pikwitonei. The second part is the northeastern region, which is characterized by pervasive metamorphic rocks of granulite-facies.
The hemagglutinin-esterase (HE) glycoprotein of Influenza C virus is composed of three domains: a stem domain active in membrane fusion (F), an acetylesterase domain (E), and a receptor-binding domain (R). The protein contains eight N-linked glycosylation sites, four (positions 26, 395, 552, and 603) in the F domain, three (positions 61, 131, and 144) in the E domain, and one (position 189) in the R domain. Oligosaccharide chains in the domains influence intracellular transport. A study showed that it was evident that glycosylation at the two sites in the F domain (positions 26 and 603), in addition to that in the E domain (position 144), is required for the HE molecule to be transported from the endoplasmic reticulum and that mutant HEs lacking one of these three sites failed to undergo the trimer assembly.
In molecular biology, the LisH domain (lis homology domain) is a protein domain found in a large number of eukaryotic proteins, from metazoa, fungi and plants that have a wide range of functions. The recently solved structure of the LisH domain in the N-terminal region of LIS1 depicted it as a novel dimerisation motif, and that other structural elements are likely to play an important role in dimerisation. The LisH domain is found in the Saccharomyces cerevisiae SIF2 protein, a component of the SET3 complex which is responsible for repressing meiotic genes In SIF2 the LisH domain has been shown to mediate dimer and tetramer formation. It has been shown that the LisH domain helps mediate interaction with components of the SET3 complex.
Responses to discovered hijackings vary; sometimes the registration information can be returned to its original state by the current registrar, but this may be more difficult if the domain name was transferred to another registrar, particularly if that registrar resides in another country. If the stolen domain name has been transferred to another registrar, the losing registrar may invoke ICANN's Registrar Transfer Dispute Resolution Policy to seek the return of the domain. In some cases the losing registrar for the domain name is not able to regain control over the domain, and the domain name owner may need to pursue legal action to obtain the court ordered return of the domain. In some jurisdictions, police may arrest cybercriminals involved, or prosecutors may file indict.
The area of present-day Kashiwazaki was part of ancient Echigo Province and developed as a post station on the Hokuriku-dō highway. Under the Tokugawa shogunate of Edo period Japan, parts of what is now Kashiwazaki were under the control of Shiiya Domain, a minor fudai feudal domain ruled by a junior branch of the Hori clan, while other parts were tenryō territory under direct control of the shogunate, or were exclaves of Kuwana Domain (Ise Province), Kaminoyama Domain (Mutsu Province), Nagaoka Domain (Echigo Province) or Yoita Domain (Echigo Province). Pre-modern Kashiwazaki was located within the holdings of Kuwana Domain. The modern town of Kashiwazaki was established on April 1, 1889, within Kariwa District, Niigata with the establishment of the municipalities system.
This N-terminal extension contains a protein kinase domain that has approximately 50% sequence identity to the sequences of ROCK, ROK, myotonic dystrophy protein kinase (MDPK) and the CDC42 effector known as MRCK or GEK. Citron kinase, which resembles the ROCK family of kinases and by comparison to it, is therefore a multiple domain protein containing an N-terminal kinase domain, an internal coiled-coil (CC) domain with Rho/Rac interacting site, and a C-terminal region consisting of a Zn finger, a pleckstrin homology (PH) domain, a Citron homology domain (CNH), a putative SH3 binding domain, and a PDZ-targeting motif. Its fly (Drosophila) ortholog is called Sticky. the importance of different domains of citron-K in its localization at different stages is discussed below.
Domain testing is one of the most widely practiced software testing techniques. It is a method of selecting a small number of test cases from a nearly infinite group of candidate test cases. Domain knowledge plays a very critical role while testing domain-specific work.
There is no official second-level domain policy. A number of domain names, typically those of other TLDs, two letter domains and potentially offensive domains are forbidden from being registered. Nevertheless, the Government of Ireland began using the `.gov.ie` domain where once it used `irlgov.ie`.
The company's general fund was the result of .hiv domain sales, which retailed for 150 euros. dotHIV hoped to direct 70 percent of its income from domain sales to the general fund. Domain sales also funded dotHIV's operations and the debt required to finance the .
The core domain located at the C-terminus part of the copine is found to have a unique and conserved primary sequence. The function of the core domain is still uncertain, however, researchers believe it has a similar function to the "A domain" in integrins.
The Flin Flon domain is in the center of the Trans-Hudson Suture Zone and extends over the border of the Manitoba- Saskatchewan segment east and west. It is west of the Superior Craton, south of the Kisseynew Domain, and east of the Glennie Domain.
This is a list of organizations with `INT` domain names, in alphabetical order of the second-level domain name. The list is not comprehensive. As of June 2012, the `INT` domain consists of 166 subdomain delegations. These organizations are generally international organizations established by treaty.
To prevent non-international domain names containing hyphens from being accidentally interpreted as Punycode, international domain name Punycode sequences have a so-called ASCII Compatible Encoding (ACE) prefix, "xn--", prepended. Thus the domain name "bücher.tld" would be represented in ASCII as "xn--bcher-kva.tld".
Structurally, HtrA2 is a trimeric molecule with central protease domains and a carboxy-terminal PDZ domain, which is characteristic of the HtrA family. The PDZ domain preferentially binds C-terminus of the protein substrate and modulate the proteolytic activity of the trypsin-like protease domain.
FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene. It is a member of the FYVE, RhoGEF and PH domain containing family.
The Internationalizing Domain Names in Applications (IDNA) system allows user applications, such as web browsers, map Unicode strings into the valid DNS character set using Punycode, which is called internationalized domain names. However, to simplify implementations, internationalized domain names are not allowed in UTIDs.
The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated potassium channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. This domain is found in a subset of a larger group of proteins that contain the BTB/POZ domain.
Second-level domain names must be at least three letters long. Two-letter subdomain names are restricted to the Swiss cantons, as well as the domain ch.ch of the Federal Chancellery of Switzerland. The only exception has been the former domain of the Expo.
The .ch domain is very popular in domain hacks, used to spell words and names that end in "ch": for example, Techcrunch's tcrn.ch. This phenomenon is not limited to English; to take another example, the domain scha.ch (Schach, German for "chess") has been registered.
Since 2011 due to changes in currency exchange rate the price has decreased. The costs to use a .by domain is a US$12 fee for the first year and second payment of $12 to maintain the domain. The renewal of the domain occurs yearly.
As an example, in the domain example.co.uk, co is the second-level domain. Next are third-level domains, which are written immediately to the left of a second-level domain. There can be fourth- and fifth-level domains, and so on, with virtually no limitation.
Time domain reflectometry, specifically spread- spectrum time-domain reflectometry is used on aviation wiring for both preventive maintenance and fault location.Smith, P., C. Furse, and J. Gunther, 2005. "Analysis of spread spectrum time domain reflectometry for wire fault location ". IEEE Sensors Journal 5:1469–1478.
The multidelay block frequency domain adaptive filter (MDF) algorithm is a block-based frequency domain implementation of the (normalised) Least mean squares filter (LMS) algorithm.
When cAMP binds, the domain dissociates and exposes the now-active GEF domain, allowing Epac to activate small Ras-like GTPase proteins, such as Rap1.
This protein domain shares sequence homology with the C-terminal domain of GatB and GatE, the tRNA-binding subunits of bacterial and archaeal glutamine amidotransferases.
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ASAP1 gene.
Registering this domain name > requires permission from the Registrant(s) that already holds the domain > name(s): gouv.on.ca, gouv.pe.ca, gouv.qc.ca. Contact CIRA for more > information.
On 31 December 2019, there were 280,958 registered .ie domain names. This has surpassed the number of Irish-owned and or hosted .com domain names.
The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges.
His wife was a daughter of Matsudaira Nobuhide of Kameyama Domain. After her death, he remarried to a daughter of Kutsuki Tsunaeda of Fukuchiyama Domain.
For gram positive bacteria lysins, the N-terminal domain catalyses the hydrolysis of peptidoglycan whereas the C-terminal domain binds to the cell wall substrate.
However, later the same month, the government issued a decree abolishing the domain system. The former domain was absorbed into Yamagata Prefecture in July 1871.
On November 29, 2017 almost twenty years after its registration the HackCanada.com domain went offline and now displays a "This Domain Name Has Expired" message.
IDN.IDN is an abbreviation for an Internationalized domain name whose Top level domain (TLD) is also internationalized, which could be transliterated .com, .net, .org, etc.
In 2004, the company bought the domain name CK.com. Calvin Klein is one of the few corporations worldwide to own a two letter domain name.
Clinger [1981] constructed a power domain for the Actor model building on the base domain of Actor event diagrams, which is incomplete. See Clinger's model.
United Ohana owned locations, still branded Roy's, are accessible under the roysrestaurant.com domain name. Locations owned by Roy Yamaguchi are accessible under the royshawaii.com domain.
Japan has considered registering an internationalized country code top-level domain, .日本.About '.日本' As of 2016, no such domain has been registered.
For particularly popular domain names, there are often multiple parties anticipating the expiration. Competition for expiring domain names has since become a purview of drop catching services. These services offer to dedicate their servers to securing a domain name upon its availability, usually at an auction price. Individuals with their limited resources find it difficult to compete with these drop catching firms for highly desirable domain names.
The PASTA domain is a small protein domain that can bind to the beta-lactam ring portion of various β-lactam antibiotics. The domain was initially discovered in 2002 by Yeats and colleagues as a region of sequence similarity found in penicillin binding proteins and PknB-like kinases found in some bacteria. The name is an acronym derived from PBP and Serine/Threonine kinase Associated domain.
Ankyrin repeat domain-containing protein 26 has three conserved domains: ANK, SbcC, and DUF3496. ANK conserved domain is located from amino acid 74-199. Ankyrin repeats are found to mediate protein-protein interactions, and also contains two antiparallel helices, as well as a beta-hairpin. SbcC conserved domain can be found from amino acid 743-1333, and is domain associated with ATPase involved in DNA repair.
GPR113 Var 1 contains 1079 Amino Acids, and is integral to the plasma membrane. The 7-pass receptor contains 4 domains highlighted in the figure at right: Signal Peptide (Red), Hormone Receptor Domain (Blue), Latrophilin/CL-1-like GPS domain (Orange), and the 7-transmembrane receptor (Purple). Between the Hormone Receptor Domain and the GPS is a Domain of unknown function that is not highlighted.
WRKY transcription factors contain either one or two WRKY protein domains. The WRKY protein domain is 60 to 70 amino acids long type of DNA binding domain. The domain is characterized by a highly conserved core WRKYGQK motif and a zinc finger region. The cysteine and histidine zinc finger domain occurs as a CX4-5CX22-23HXH or CX7CX23HXC type, where X can be any amino acid.
This is done to prevent certain domain names from being used against the person or business. It is common for a larger business to have domain names registered by multiple employees at multiple domain name registrars, possibly a result of organizational or geographical requirements. Consequently, a web presence management system can be used to monitor all domain names registered by the business, regardless of the registrars used.
Mathematical notation aside, the motivation behind integral transforms is easy to understand. There are many classes of problems that are difficult to solve—or at least quite unwieldy algebraically—in their original representations. An integral transform "maps" an equation from its original "domain" into another domain. Manipulating and solving the equation in the target domain can be much easier than manipulation and solution in the original domain.
Rowen (1994), p. 99. Mathematical literature contains multiple variants of the definition of "domain".Some authors also consider the zero ring to be a domain: see Polcino M. & Sehgal (2002), p. 65. Some authors apply the term "domain" also to rngs with the zero-product property; such authors consider nZ to be a domain for each positive integer n: see Lanski (2005), p. 343.
Impaired function of PGM3 is demonstrated by decreased enzyme activity, reduced UDP-GlcNAc and reduced N-linked glycosylation and O-linked glycosylation PGM3 is composed of four protein domains: active serine domain, metal-binding domain, sugar-binding domain, and phosphate-binding domain. Missense and deletion mutations have been discovered within multiple of these domains. All identified mutant PGM3 retain catalytic specificity however weaken enzymatic activity.
The mature Fas protein has 319 amino acids, has a predicted molecular weight of 48 kiloDaltons and is divided into 3 domains: an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain has 157 amino acids and is rich in cysteine residues. The transmembrane and cytoplasmic domains have 17 and 145 amino acids respectively. Exons 1 through 5 encode the extracellular region.
A chloride ion binding site has been identified in the region 320DLG323 of the kinase domain in WNK4. The binding of chloride Cl− in this region inhibits the activation of WNK4. The autoinhibitory domain is a homolog of the RFXV-binding PASK/FRAY homology 2 (PF2) domain. Structural studies have revealed that the autoinhibitory domain consists of three β-strands and two α-helices.
The notion of a Dedekind–Hasse norm was developed independently by Richard Dedekind and, later, by Helmut Hasse. They both noticed it was precisely the extra piece of structure needed to turn an integral domain into a principal ideal domain. To wit, they proved that an integral domain R is a principal ideal domain if and only if R has a Dedekind–Hasse norm.
StAR is the prototypic member of the START domain family of proteins and is thus also known as STARD1 for "START domain- containing protein 1". It is hypothesized that the START domain forms a pocket in StAR that binds single cholesterol molecules for delivery to P450scc. The closest homolog to StAR is MLN64 (STARD3). Together they comprise the StarD1/D3 subfamily of START domain-containing proteins.
If the domain name is completely specified, including a top-level domain of the Internet, then the hostname is said to be a fully qualified domain name (FQDN). Hostnames that include DNS domains are often stored in the Domain Name System together with the IP addresses of the host they represent for the purpose of mapping the hostname to an address, or the reverse process.
The LINC complex (Linker of Nucleoskeleton and Cytoskeleton) is a protein complex associated with both inner and outer membranes of the nucleus. It is composed of SUN-domain proteins and KASH-domain proteins. The SUN-domain proteins are associated with both nuclear lamins and chromatin and cross the inner nuclear membrane. They interact with the KASH domain proteins in the perinuclear (lumen) space between the two membranes.
Calponin is mainly made up of α-helices with hydrogen bond turns. It is a binding protein and is made up of three domains. These domains in order of appearance are Calponin Homology (CH), regulatory domain (RD), and Click-23, domain that contains the calponin repeats. At the CH domain calponin binds to α-actin and filamin and binds to actin within the RD domain.
A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity.
The domain name was originally allocated by Jon Postel, operator of IANA to Kevin Robert Elz of Melbourne University in 1986. After an approximately five-year process in the 1990s, the Internet industry created a self-regulatory body called .au Domain Administration to operate the domain. It obtained assent from ICANN in 2001, and commenced operating a new competitive regime for domain registration on 1 July 2002.
FGFR1OP2, when fused with the fibroblast growth factor receptor 1 (FGFR1), is shown to cause myeloproliferative syndrome. The protein encoded by the FGFR1 gene belongs to the fibroblast growth factor receptor family. FGFRs usually contain an extracellular ligand binding domain, a single transmembrane domain, and an intracellular tyrosine kinase domain. The extracellular domain specifies which ligand the receptor will bind to and mediates ligand-induced receptor dimerization.
A homology domain is generally longer than motifs. The domain may include all of a given protein sequence or only a portion of the sequence. Some domains are complex and made up of several smaller homology domains that became joined to form a larger one during evolution. A domain that covers an entire sequence is called the homeomorphic domain by PIR (Protein Information Resource).
As of January 2009, CNNIC only opens the CN domain to registered businesses, requires supporting documentations for domain registration such as business license or personal ID, and suspended overseas registrars even for domestic registrants. CNNIC denies that it mandates existing personal domain names to be transferred to businesses. Trend Micro suggests this move is still not enough to stop modern security threats from the .cn domain.
Domains in Windows NT 4.0 and earlier only have global (domain- level) and local (non-domain) groups and do not support group nesting at the domain level. The abbreviation AGLP refers to these limitations as applied to RBAC implementations in older domains: _G_ lobal groups represent business roles, while _l_ ocal groups (created on the domain member servers themselves) represent permissions or user rights.
The domain was suppressed in 1679, and Kururi Castle was allowed to fall into ruin. In 1742, Kururi Domain was reinstated, with Kuroda Naozumi transferred from Numata Domain in Kazusa Province. He rebuilt the fortifications of the old castle, and his descendants continued to rule Kururi Domain until the Meiji Restoration. In 1872, by orders of the Meiji government, the surviving structures of Kururi Castle were destroyed.
His descendants resided successively at Odawara Domain (105,000 koku) in Sagami Province from 1632 through 1685; at Takata Domain in Echigo province from 1685 through 1701; at Sakura Domain in Shimōsa Province from 1701 through 1723. Masanari's heirs settled at Yodo Domain (115,000 koku) in Yamashiro Province from 1723 through 1868. The head of this clan line was ennobled as a "Viscount" in the Meiji period.
Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain. This gene encodes a member of the trypsin family of serine proteases.
All members of the TEAD family share a highly conserved DNA binding domain called the TEA domain. This DNA binding domain has a consensus DNA sequence 5’-CATTCCA/T-3’ that is called the MCAT element. The three dimensional structure of the TEA domain has been identified [5]. Its conformation is close to that of the homeodomain and contains 3 α helixes (H1, H2 and H3).
Removal of HS chains may affect matrix organization and endothelial barrier function. Domain II comprises four repeats homologous to the ligand- binding portion of the LDL receptor with six conserved cysteine residues and a pentapeptide, DGSDE, which mediates ligand binding by the LDL receptor. Domain III has homology to the domain IVa and IVb of laminin. Domain IV consists of a series of IG modules.
A drop catcher is a domain name registrar who offers the service of attempting to quickly register a given domain name for a customer if that name becomes available—that is, to "catch" a "dropped" name—when the domain name's registration expires and is then deleted, either because the registrant abandons the domain or because the registrant did not renew the registration prior to deletion.
The Savings.com domain was purchased in 2003 by a founder of the affiliate marketing company Commission Junction, Inc.Estalea Press Release Santa Barbara Entrepreneur Launches High-Tech Holding Company Estalea The savings.com domain sold for $1.9 million and ranks among the top 40 most expensive domains ever sold.Biggest Domain Sales Ever Top domain sales The company originally functioned as a lead generation resource in 2004. Savings.
Anillin has a unique multi-domain structure. At the N-terminus, there is an actin- and myosin- binding domain. At the C-terminus, there is a PH domain. The PH domain is conserved and essential for anillin functionality. The human anillin cDNA, located on Chr7, encodes a 1,125–amino acid protein with a predicted molecular mass of 124 kD and a pI of 8.1.
The ownership of a website usually can be ascertained via the registration of the domain name via the Domain Name System. The Registrant record of the DNS identifies the individual or company who has the right to use, sell or destroy a domain name. Ownership of the domain name does not guarantee ownership of the website to which it points or the content contained there.
CD79a is a membrane protein with an extracellular immunoglobulin domain, a single span transmembrane region and a short cytoplasmic domain. The cytoplasmic domain contains multiple phosphorylation sites including a conserved dual phosphotyrosine binding motif, termed immunotyrosine-based activation motif (ITAM). The larger CD79a isoform contains an insert in position 88-127 of human CD79a resulting in a complete immunoglobulin domain, whereas the smaller isoform has only a truncated Ig-like domain. CD79a has several cysteine residues, one of which forms covalent bonds with CD79b.
In molecular biology, the BLUF domain (sensors of blue-light using FAD) is a FAD-binding protein domain. They are present in various proteins, primarily from bacteria, for example a BLUF domain is found at the N-terminus of the AppA protein from Rhodobacter sphaeroides. The BLUF domain is involved in sensing blue-light (and possibly redox) using FAD and is similar to the flavin-binding PAS domains and cryptochromes. The predicted secondary structure reveals that the BLUF domain has a novel FAD-binding fold.
The O1 protein consists of seven such fragments, namely Met (methyltransferase), Y (Y-domain), Plp (papain-like protease), V (proline-rich variable region), X (X-domain, macro- domain), Hel (helicase), and Rdrp (RNA-dependent RNA polymerase). The Pvx domain is a fusion protein consisting of the Plp, V, and X domains. The O3 protein is encoded by a single open-reading frame (ORF3). The O2 protein encodes the capsid, which is composed of three domains, namely the shell domain (S) and two protruding domains (P1, P2).
Complementing language-oriented programming, as well as all other forms of domain-specific languages, are the class of compiler writing tools called metacompilers. A metacompiler is not only useful for generating parsers and code generators for domain-specific languages, but a metacompiler itself compiles a domain-specific metalanguage specifically designed for the domain of metaprogramming. Besides parsing domain-specific languages, metacompilers are useful for generating a wide range of software engineering and analysis tools. The meta-compiler methodology is often found in program transformation systems.
The Domain Master Browser is necessary on a routed TCP/IP network, that is, when a Windows domain spans more than one TCP/IP network. When a Windows domain spans multiple subnets each of the subnets has an independent browser called the Master Browser. The Master Browser is responsible for the browse list within its respective subnet and portion of the domain on its subnet. The Domain Master Browser is used to collect information from each of the Master Browsers via the NetServerEnum API call.
Starting in April 2009, many top level domains (TLDs) began transitioning from the $0.18 fee for excess domains deleted to implementing a policy resulting in a fee equal to registering the domain.The End Of Domain Tasting. ICANN Report on AGP Measures 12 August 2009 In August 2009, ICANN reported that prior to implementing excess domain deletion charges, the peak month for domain tastings was over 15 million domain names. After the $0.20 fee was implemented, tastings dropped to around 2 million domain names per month.
Tsugaru Nobuyasu was the eldest son of Tsugaru Nobuyasu, 7th daimyō of Hirosaki Domain. In 1776, he was received in formal audience by shōgun Tokugawa Ieharu and succeeded his father in 1784. Noted for his intelligence and learning at an early age, he corresponded with a number of other daimyō noted for their good government, including Hosokawa Shigekata of Kumamoto Domain, Uesugi Harunori of Yonezawa Domain and Matsudaira Sadanobu of Shirakawa Domain. Nobuakira inherited a domain stricken by extensive famine caused by repeated natural disasters and mismanagement.
An appropriate example is pyruvate kinase (see first figure), a glycolytic enzyme that plays an important role in regulating the flux from fructose-1,6-biphosphate to pyruvate. It contains an all-β nucleotide binding domain (in blue), an α/β-substrate binding domain (in grey) and an α/β-regulatory domain (in olive green), connected by several polypeptide linkers. Each domain in this protein occurs in diverse sets of protein families. The central α/β-barrel substrate binding domain is one of the most common enzyme folds.
The kinase domain of WNK4 has an 83% sequence identity with that of WNK1. The overall fold of the kinase domain of WNK1 resembles those of other protein kinases that have a typical dual-domain architecture. The C-terminal domain of WNK4 bears a high degree of similarity to other kinases within the family. On the other hand, the N-terminal domain is unique in having a six-stranded instead of a five-stranded β sheet to form a complete β barrel. Fig. 1.
ETF-QO Functional Domains ETF-QO consists of one structural domain with three functional domains packed in close proximity: a FAD domain, a 4Fe4S cluster domain, and a UQ-binding domain. FAD is in an extended conformation and is buried deeply within its functional domain. Multiple hydrogen bonds and a positive helix dipole modulate the redox potential of FAD and can possibly stabilize the anionic semiquinone intermediate. The 4Fe4S cluster is also stabilized by extensive hydrogen bonding around the cluster and its cysteine components.
Exons are peptide encoding regions of DNA genes that remain in the transcript after splicing and during the maturation of mRNA. The mRNA transcript encodes for a receptor protein that is made up of three distinct parts: an intracellular domain, a transmembrane domain, and an extracellular domain. Specifically, part of exon 2 and exons 3-7 of the GHR gene will translate to amino acids that make up the extracellular domain of GHR. This extracellular domain physically binds GH in the receptor-ligand interaction.
A move to introduce this service by ICANN-accredited registries drew fire in 2003 as anti-competitive. Currently domain name registrars provide a similar, non-guaranteed service by continually querying the registry if a domain name is available. If it should become available, the registrar quickly tries to register the domain to the new party. The consequence of this process is that, if multiple registrars are vying for the domain, the beneficiary of the new domain name may come down to luck and circumstance.
In 1717, Iiyama Domain was awarded to a cadet branch of the Honda clan, under whose control it remained until the Meiji Restoration. During the Boshin War, the domain was invaded by pro-Tokugawa forces from Takada Domain, who set fire to the castle town. The domain subsequently supported the imperial armies at the Battle of Hokuetsu and Battle of Aizu. In July 1871, with the abolition of the han system, Iiyama Domain briefly became Iiyama Prefecture, and was merged into the newly created Nagano Prefecture.
In molecular biology, the GGDEF domain is a protein domain which appears to be ubiquitous in bacteria and is often linked to a regulatory domain, such as a phosphorylation receiver or oxygen sensing domain. Its function is to act as a diguanylate cyclase and synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria. Enzymatic activity can be strongly influenced by the adjacent domains. Processes regulated by this domain include exopolysaccharide synthesis, biofilm formation, motility and cell differentiation.
Sometimes has a derivative at most, but not all, points of its domain. The function whose value at equals whenever is defined and elsewhere is undefined is also called the derivative of . It is still a function, but its domain is strictly smaller than the domain of . Using this idea, differentiation becomes a function of functions: The derivative is an operator whose domain is the set of all functions that have derivatives at every point of their domain and whose range is a set of functions.
The N-terminal 214 amino acids are dispensable for relaxation of supercoiling activity in vitro and there are four nuclear localization signals and sites for interaction with other cellular proteins within the N-terminal domain. The N-terminal domain is followed by a highly conserved, 421 amino acid core domain containing all of the catalytic residues except the active site tyrosine. This is followed by a poorly conserved linker domain of 77 amino acids. Finally there is a 53 amino acid C-terminal domain.
An approved domain name dispute program provider for ICANN, the NAF has administered over 10,000 domain name disputes since 1999.Domains The number of domain name disputes administered is on the rise, up 143 cases from 2006 to 2007. The NAF deals predominantly with registered domain names that are abused by parties who have no legitimate rights to them. Some of the famous trademarks involved in NAF domain name dispute resolutions include Los Angeles Angels, Disney, Hershey's Kisses, Jimmy Buffett, and Univision, most recently Bill Clinton.
That means that in those countries, the works of authors who died, anywhere in the world, throughout the year of , passed into public domain on 1 January . Since public domain rights vary based on jurisdiction, the passage of a work into the public domain is not worldwide. The most noticeable exception is the United States, where no additional published works entered the public domain automatically from 1999 to 2018. Australia copyright scheme is even more restrictive, with no Public Domain Day possible until 2026.
There are 9 members part of the Src family kinases: c-Src, Yes, Fyn, Fgr, Yrk, Lyn, Blk, Hck, and Lck. The expression of these Src family members are not the same throughout all tissues and cell types. Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. c-Src is made up of 6 functional regions: Src homology 4 domain (SH4 domain), unique region, SH3 domain, SH2 domain, catalytic domain and short regulatory tail.
Even so, since the logical data model anticipates implementation on a specific computing system, the content of the logical data model is adjusted to achieve certain efficiencies. The term 'Logical Data Model' is sometimes used as a synonym of 'domain model' or as an alternative to the domain model. While the two concepts are closely related, and have overlapping goals, a domain model is more focused on capturing the concepts in the problem domain rather than the structure of the data associated with that domain.
BAG proteins compete with Hip-1 for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells.
Even though PTPmu dimers may be active, an additional study suggests that the extracellular domain of PTPmu reduces phosphatase activity. In this study, it was shown that the cytoplasmic domain of PTPmu (a PTPmu molecule lacking the extracellular domain) has greater phosphatase activity than the full-length protein in an enzymatic phosphatase assay. PTPmu has a long juxtamembrane domain, which likely influences catalytic activity. The juxtamembrane domain of PTPmu can bind to either the D1 and/or D2 of PTPmu, but only within the same PTPmu monomer.
By June 2007, 21 states had enacted substantive eminent domain reform and another 21 states had increased eminent domain protections but not nearly enough to prevent takings allowed by the Kelo decision. Eight states had not passed any legislation reforming their eminent domain laws.Castle Coalition - Legislative Center The Castle Coalition provides model legislative language for eminent domain reform, stricter blight statutes and state constitutional amendments. The Castle Coalition also has several publications documenting the extent and nature of eminent domain abuse across the United States.
The A domain serves as a built-in protein phosphatase that functions to dephosphorylate the phosphorylated P domain. The A domain is the smallest of the three cytoplasmic domains. It consists of a distorted jellyroll structure and two short helices. It is the actuator domain modulating the occlusion of the transported ligand(s) in the transmembrane binding sites, and it is pivot in transposing the energy from the hydrolysis of ATP in the cytoplasmic domains to the vectorial transport of cations in the transmembrane domain.
In 2010, Creative Commons announced its Public Domain Mark, a tool for labeling works already in the public domain. Together, CC0 and the Public Domain Mark replace the Public Domain Dedication and Certification, which took a U.S.-centric approach and co-mingled distinct operations. In 2011, the Free Software Foundation added CC0 to its free software licenses, and currently recommends CC0 as the preferred method of releasing software into the public domain. In February 2012 CC0 was submitted to Open Source Initiative (OSI) for their approval.
Under the Copyright Term Extension Act, books published in 1925, films released in 1925, and other works published in 1925, will enter the public domain in 2021. Additionally, unpublished works whose authors died in 1950 will enter the public domain. No United States audio recordings will enter the public domain; under the Music Modernization Act, those published in 1925 will not enter the public domain until 2026. However, international audio recordings published in 1925 enter the public domain, as will all sheet music published in 1925.
Viscount (July 7, 1852 - February 26, 1887) was the 10th Tamura daimyō of Ichinoseki Domain. His courtesy title was Sakyō-no-daifu, and his Court rank was Junior Fifth Rank, Lower Grade. Kuniyoshi was the 7th son of Ishikawa Yoshimitsu, the 13th hereditary chieftain of the Ishikawa clan, a cadet branch of the Date clan of Sendai Domain. In 1863, Tamura Yukiaki, the 9th daimyō of Ichinoseki Domain was adopted by Date Yoshikuni as heir apparent to Sendai Domain, which left Ichinoseki Domain leaderless.
Response regulators can be divided into at least three broad classes, based on the features of effector domains: regulators with a DNA-binding effector domain, regulators with an enzymatic effector domain, and single-domain response regulators. More comprehensive classifications based on more detailed analysis of domain architecture are possible. Beyond these broad categorizations, there are response regulators with other types of effector domains, including RNA- binding effector domains. Regulators with a DNA-binding effector domain are the most common response regulators, and have direct impacts on transcription.
L27_2 domain-mediated protein assemblies have been shown to play essential roles in cellular processes including asymmetric cell division, establishment and maintenance of cell polarity, and clustering of receptors and ion channels. Members of this family form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The two N-terminal helices of each L27_2 domain pack together to form a tight, four- helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two units of the heterodimer into a tetramer. The L27_N domain is often found at the N-terminus of the L27 domain.
In computer networks, a reverse DNS lookup or reverse DNS resolution (rDNS) is the querying technique of the Domain Name System (DNS) to determine the domain name associated with an IP address – the reverse of the usual "forward" DNS lookup of an IP address from a domain name. The process of reverse resolving of an IP address uses PTR records. rDNS involves searching domain name registry and registrar tables. This may be used to try to identify the originator’s domain name to track, for example, a spammer sending spam emails or the domain name of a computer trying to break into a firewall or someone trying to hack the system.
Outraged farmers seized control of the domain, and even attempted to storm Yashiro's Edo residence, and the rebellion was suppressed by force from the Tokugawa shogunate, leading to many executions. The Yashiro were then dispossessed from their domain and reduced to hatamoto status. On October 18, 1725, the domain was revived for Mizuno Tadasada, a hatamoto, and the younger son of a hatamoto whose holding passed the 10,000 koku qualifying mark to become a daimyō. His descendants continued to rule the small domain until 1827, when Mizuno Tadateru transferred his residence to what is now part of Ichihara in neighboring Kazusa Province, and renamed to domain "Tsurumaki Domain".
In molecular biology, the type IV collagen C4 domain (or collagen IV NC1 domain) is a duplicated domain present at the C-terminus of type IV collagens. Each type IV collagen contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 amino acids and a globular non-collagenous C4 domain of ~230 amino acids at the N and C terminus, respectively. In protomer assembly, the C4 domains of three chains interact, forming an C4 trimer, to select and register chains for triple helix formation. In network assembly, the C4 trimers of two protomers interact, forming a C4 hexamer structure, to select and connect protomers.
The structure is L-shaped with a long, hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm that includes all the known redox centers and the NADH binding site. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of Complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and that the hydrophobic domain acts as an anchor for the NADH dehydrogenase (ubiquinone) complex at the inner mitochondrial membrane.
Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled-coil domain involved in the multimerization. The crystal structure of the kinase domain of DMPK bound to the inhibitor bisindolylmaleimide VIII (BIM-8) revealed a dimeric enzyme associated by a conserved dimerization domain. The affinity of dimerisation suggested that the kinase domain alone is insufficient for dimerisation in vivo and that the coiled-coil domains are required for stable dimer formation. The kinase domain is in an active conformation, with a fully ordered and correctly positioned aC helix, and catalytic residues in a conformation competent for catalysis.
The Cas12a locus contains a mixed alpha/beta domain, a RuvC-I followed by a helical region, a RuvC-II and a zinc finger-like domain. The Cpf1 protein has a RuvC-like endonuclease domain that is similar to the RuvC domain of Cas9. Furthermore, Cpf1 does not have a HNH endonuclease domain, and the N-terminal of Cas12a does not have the alpha- helical recognition lobe of Cas9. Cpf1 CRISPR-Cas domain architecture shows that Cpf1 is functionally unique, being classified as Class 2, type V CRISPR system. The Cas12a loci encode Cas1, Cas2 and Cas4 proteins more similar to types I and III than from type II systems.
The total revenues of 10,000 koku enabled Tsugaru Chikatari and his successors to enter the ranks of the daimyō. The 2nd daimyō of Kuroishi Domain, Tsugaru Yukitsugu became daimyō of Hirosaki Domain after the forced retirement of Tsugaru Nobuyuki, turning the Kuroishi Domain over to his younger brother Tsugaru Tsuguyasu. During the Boshin War of the Meiji Restoration, the 4th daimyō of Kuroishi Tsugaru Tsugumichi initially supported the Ōuetsu Reppan Dōmei, but then defected to the Imperial cause and joined with the forces of Hirosaki Domain at the Battle of Noheji against the forces of Hachinohe Domain and Morioka Domain. Afterwards, his forces also fought in campaigns in Hokkaidō.
Dock11 exhibits the same domain arrangement as other members of the DOCK-D/Zizimin subfamily and shares the highest level of sequence identity with Dock9. It contains a DHR2 domain which mediates GEF activity and a DHR1 domain which may interact with membrane phospholipids. It also contains an N-terminal PH domain which may be involved in its recruitment to the plasma membrane. Dock11 binds and activates nucleotide-free Cdc42 via its DHR2 domain and has also been reported to mediate positive feedback on active, GTP-bound Cdc42, although this interaction required a small N-terminal region of Dock11 in addition to the DHR2 domain.
Since the active sites of each catalytic domain are separated by a distance of 40 Å, they are not believed to allosterically effect one another. In contrast, the linker domain is composed of α helices supplied by the two catalytic domains: each domain contributes five helices from their N termini and one from a helix that spans both the catalytic domain and the linker domain. At the center of the linker domain resides an 8 by 35 Å hydrophobic tunnel with two phospholipids bound at each end. The head of each phospholipid points outward towards solution while the tails are embedded within the enzyme.
The UK's domain has over 7.7 million domains registered according to Nominet's domain registration statistics webpage, mainly in its commercial sub-domain co.uk. These TLDs are mature markets where good domain names may command high prices. The EU ccTLD is an example of what happens when speculative activity overtakes "ordinary" domain registrations..eu ccTLD Landrush period controversy. A combination of an inept registry (EURid) and excessive speculation by businesses exploiting a poorly structured regulatory framework meant that, according to EURid's own statistics at the end of 2006, over 50% of the registrations could be considered at best speculative and at worst domain name warehousing.
An internationalized country code top-level domain is a top-level domain in the Domain Name System (DNS) of the Internet. IDN ccTLDs are specially encoded domain names that are displayed in an end user application, such as a web browser, in their language-native script or alphabet, such as the Arabic alphabet, or a non-alphabetic writing system, such as Chinese characters. IDN ccTLDs are an application of the internationalized domain name system to top- level Internet domains assigned to countries, or independent geographic regions. Although the domain class uses the term code, some of these ccTLDs are not codes but full words.
HoloEnzyme: The holoenzyme SDH contains 319 residues, 1 PLP cofactor molecule, and 131 water molecules. The overall fold of the monomer is very similar to that of other PLP-dependent enzymes of the Beta-family. The enzyme contains a large domain (catalytic domain or PLP- binding domain) and a small domain. The domains are joined by two peptide linkers (residues 32-35 and 138-146), with the internal gap created being the space for the active site (Figure 1). File:LargeandSmallDomainSDH.jpg Figure 1 shows the large catalytic domain in purple and cyan and the small regulatory domain in green in a monomer of Serine Dehydratase.
Edo daimyo.net The clan’s Edo temple was Tessho-ji in Nishi-Asakusa. During the Bakumatsu period, the domain strongly supported the Tokugawa shogunate, and samurai from the domain played a key role in the attack on the Satsuma Domain residence in Edo. During the Boshin War, the domain joined the Ōuetsu Reppan Dōmei and troops from the domain were involved in the Battle of Hokuetsu, as a substantial portion of the domain’s holdings were also in Echigo Province. After the end of the conflict, with the abolition of the han system in July 1871, Kaminoyama Domain became “Kaminoyama Prefecture”, which later became part of Yamagata Prefecture.
"Potential Registrants are effectively forced to purchase the domain from Network Solutions for a period of four days at which point the domain is dropped", wrote Tucows employee James Koole. Koole says that Tucows has found a way to address the issue of domain tasting and has policies in place that uphold the rights of Registrants. "Tucows works to prevent domain name tasting by charging our Resellers a monetary fee on domain name registrations that are cancelled within the five-day Add Grace Period (AGP)", Koole said. "Tucows doesn't use WHOIS query data or search data from our API to front-run domain names", Koole added.Tucows.
The enzyme can be found in a monofunctional form, in some bacteria and yeast. Structural analysis of the yeast monofunctional enzyme indicates that the enzyme is a dimer composed of three distinct regions; an N-terminal nucleotide-binding domain, a short central dimerisation region, and a C-terminal catalytic domain. The N-terminal domain forms a modified Rossmann fold, while the catalytic domain forms a novel alpha-beta mixed sheet. The enzyme can also be found in a bifunctional form consisting of an N-terminal aspartokinase domain and a C-terminal homoserine dehydrogenase domain, as found in bacteria such as Escherichia coli and in plants.
Hungarian domains sometimes use the Moroccan top level domain .ma (meaning "today"). The Moldovan domain, .md, is used by doctors and medical companies, such as doctors.
The McCann–McArthur Lake region is in the southwestern Rae Craton. The lake lies in the McCann domain just southeast of the northeast-trending Penylan domain.
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.
This new term is not applied retroactively; works that had entered the public domain between 1999 and 2018 by expiration would remain in the public domain.
In molecular biology, YopH, N-terminal refers to an evolutionary conserved protein domain. This entry represents the N-terminal domain of YopH protein tyrosine phosphatase (PTP).
AP20187 is a ligand that can induce homodimerization of fusion proteins containing the F36V mutant of an FKBP domain(FKBPF36V), available commercially as the DmrB domain.
Imabari Castle, the seat of the domain The was a Japanese domain of the Edo period, located in Iyo Province (modern-day Imabari, Ehime, on Shikoku).
The structure of the .mail domain consists of existing domain names with the new TLD appended, such as example.net.mail, associated with example.net. Unlike other domains, the .
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.
A limited number of top- level domains allow registration of domain names containing emoji characters. Emoji-containing subdomains are also possible under any top-level domain.
Chimeric nucleases are an example of engineered proteins which must comprise a DNA-binding domain to give sequence specificity and a nuclease domain for DNA cleavage.
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.
In the domain name system (DNS), .sch is a second-level domain used by several countries, including Iran (.ir), Saudi Arabia (.sa), and the United Kingdom (.
Potassium channel tetramerisation domain containing 15 also known as BTB/POZ domain-containing protein KCTD15 is protein that in humans is encoded by the KCTD15 gene.
Epistemology is not just one domain among others. Epistemological views are always at play in any domain. Those views determine or influence what is regarded relevant.
LAN Server pioneered certain file/print sharing concepts such as domains (and domain controllers), networked COM ports, domain aliases, and automatic printer driver selection and installation.
The SPR domain can occur in association with the WH1 domain (see INTERPRO) (located in the N-terminal part of the proteins) in the Spread proteins.
Microsoft originally purchased the domain name bob.com from Boston-area techie Bob Antia, but later traded it to Bob Kerstein for the windows2000.com domain name.
The FERM domain is followed by an alpha-helical domain and a hydrophilic tail. Merlin can dimerize with itself and heterodimerize with other ERM family proteins.
CA IX dimer with its four distinct pairs of domains labeled: the proteoglycan domain (PG), catalytic domain (blue), transmembrane segment (TM) and the intracellular tail (IC).
An inner gate of Tottori Castle The domain was ruled from by different branches of the Ikeda clan. The center of the domain was Tottori Castle.
Internet protocols that are focused on inter- domain functions include: Border Gateway Multicast Protocol, Classless Inter- Domain Routing, Multicast Source Discovery Protocol, and Protocol Independent Multicast.
The A domain dephosphorylates the P domain as part of the reaction cycle using a highly conserved TGES motif located at one end of the jellyroll.
This is the domain that most people are familiar with. A plot in the time domain shows the amplitude of the signal with respect to time.
Most academic uses of the top-level .be domain are due to Belnet's policy allowing only one active .ac.be domain per institution. This is why ucl.ac.
In October 2002 the news site moved to another domain name, NEWSru.com and the original domain ntv.ru was transferred to the broadcasting company under mutual agreement.
This domain has no similarity to other proteins. C1-inhibitor is highly glycosylated, bearing both N- and O-glycans. N-terminal domain is especially heavily glycosylated.
Dallas-based TIER REIT, Inc. (NYSE: TIER) owns and operates the majority of the office space offered at The Domain, including Domain 2 (115,000 square feet), Domain 3 (179,000 square feet), Domain 4 (153,000 square feet), Domain 7 (222,000 square feet) and a 50% interest in Domain 8 (291,000 square feet), which was delivered in 1Q'2017 at 98% leased. In addition, TIER REIT owns over 18 acres of fully entitled land at The Domain that can accommodate an additional 1.3 million square feet of future office space. On June 23, 2017, TIER REIT announced that it was commencing development on Domain 11, a 16-story Class A office development that will offer a new level of amenities, quality and prestige. The landmark tower within Austin’s “second downtown” is 98% pre-leased to HomeAway®, the Austin-based world leader in vacation rentals and part of the Expedia, Inc.
The training center was established near the Dutch settlement of Dejima in Nagasaki, where maximum interaction with Dutch naval technology would be possible. Nagai Naoyuki was appointed the first director with a first class of 37 cadets from the various hatamoto with fealty directly to the Shōgun, and 128 cadets sent from the various feudal han (16 from Satsuma Domain, 28 from Fukuoka Domain, 15 from Chōshū Domain, 47 from Saga Domain, 5 from Kumamoto Domain, 12 from Tsu Domain, 4 from Fukuyama Domain and one from Kakegawa Domain). Katsu Kaishū was director of training under Nagai starting from 1855, until 1859, when he was commissioned as an officer in the Shogunal navy the following year. Royal Dutch Navy officers were in charge of education, the first being Pels Rijcken (from 1855 to 1857), and the second Willem Huyssen van Kattendijke (from 1857–1859).
SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene. INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.
The new Meiji government seized the domain, and exiled Mizuno Tadahiro to a newly created 50,000 koku Asahiyama Domain in Ōmi Province in 1870. With the abolition of the han system in July 1871, the former Yamagata Domain became the nucleus of the new Yamagata Prefecture.
For example, the domain called Project, contains only one process, called Project Management, while the Benefits domain contains a Program Management process and a Portfolio Management process. Each Macroscope domain is also based on a set of fundamental principles, which help understanding, adapting and using the process.
The function of the internal XPG (XPG-I) domain contains many of cysteine and glutamate amino acid residues that are frequently found in various enzyme active sites, DNA nucleases. The I domain, together with the N-terminal forms the catalytic domain that contains the active site.
Fowler, Martin. Patterns of Enterprise Application Architecture. Addison Wesley, 2003, p. 116.Fowler, Martin. "P of EAA - Domain Model" In ontology engineering, a domain model is a formal representation of a knowledge domain with concepts, roles, datatypes, individuals, and rules, typically grounded in a description logic.
CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. CRALB protein carries 11-cis- retinol or 11-cis-retinaldehyde. It modulates interaction of retinoids with visual cycle enzymes.
Previously applications were made in the normal way, but after Nominet came to an arrangement with the education authorities, one domain per school was issued automatically. Those that had already used another domain were still given one and were able to redirect it to their main domain.
Katsuhiro was punished by the Meiji government with a reduction in revenues of 1000 koku and exile from the domain. Katsuhiro eventually became domain governor and presided over the absorption of the former domain into Ibaraki Prefecture in 1871 after the abolition of the han system.
Data emerging from the physical domain is transmitted through an information domain. Data is subsequently received and processed by a cognitive domain where it is assessed and acted upon. The process replicates the "observe, orient, decide, act" loop first described by Col. John Boyd of the USAF.
The PH domain is involved in intracellular targeting of the DH domain. It is generally thought to modulate membrane binding through interactions with phospholipids, but its function has been shown to vary in different proteins. This PH domain is also present in other proteins beyond RhoGEFs.
The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.
While inaugurating the official web domain (simhapuriuniv.ac.in) of the university, the key people here grossly neglected safeguarding and renewing the old official web domain (simhapuriuniv.org) resulting in misuse of the old domain by some fake degree racketeers. This issue came to light on 14 August 2014.
FAM83H has two known domains. The PLDc_FAM83H (phospholipase like domain) domain stretches from 17-281 on FAM83H. It lacks the functionally important histidine, so while it may share similar structure it most likely lacks PLD activity. The MIP-T3 microtubule binding domain stretches from 909-1176.
GRAM domain containing 1C also known as Aster-C is a protein that is encoded by the GRAMD1C gene. It contains a transmembrane region, a GRAM domain and a VASt domain. GRAMD1C has four paralogs: GRAMD1B and GRAMD1A and two without VASt domains, GRAMD2A and GRAMD2B.
Compared to Domain Authority which determines the ranking strength of an entire domain or subdomain, Page Authority measures the strength of an individual page.Moz - Page Authority It's a score developed by Moz on a 100-point logarithmic scale. Unlike TrustFlow, domain authority does not account for spam.
In late 2006 the Electronic Frontiers Georgia website went down. This was due to administrative reasons. The domain registration fees were not paid to TuCows and they took the domain and refused to give it back. Despite repeated requests to return the domain TuCows said no.
The structure of the N-domain of RPSA is similar to those of prokaryotic RPS2. The C-domain is intrinsically disordered in solution. The N-domain is monomeric in solution and unfolds according to a three state equilibrium. The folding intermediate is predominant at 37 °C.
The term "Schreier domain" was introduced by P. M. Cohn in 1960s. The term "pre- Schreier domain" is due to Muhammad Zafrullah. In general, an irreducible element is primal if and only if it is a prime element. Consequently, in a Schreier domain, every irreducible is prime.
Currently, twenty-four Oz books and five movies are in the public domain. Starting in 2019, an additional Oz book will enter the public domain every year. All of the Famous Forty will be in the public domain in 2059, barring another extension of copyright terms.
This gene encodes a member of the non- ribosome peptide syntesase (NRPS) enzyme family. The encoded protein contains an AMP-binding domain, PP-binding (phosphopantetheine, or pantetheine 4'phosphate-binding) domain and the Pyrrolo-quinoline quinon (PQQ) binding domain. The protein is expressed in several adult tissues.
Domain fronting does not conform to HTTP standards that require the SNI extension and HTTP Host header to contain the same domain. Large cloud service providers, including Amazon and Google, now actively prohibit domain fronting, which has made it "largely non-viable" as a censorship bypass technique.
He and his heirs ruled the domain for twelve generations until the abolition of the han system in 1871. The rating of the domain was 20,000 koku.
The protein strand then loops back towards the GTPase domain and terminates with a Proline Rich Domain that binds to the Src Homology domains of many proteins.
Akashi was established in 1617 when Ikeda Mitsumasa was transferred from the Himeji to the Tottori Domain. Himeji was split, and one piece became the Akashi Domain.
PuntuLLI is an association that promotes the creation of a top level domain in the Domain Name System of the Internet for the Leonese language and culture.
LysM and putative peptidoglycan-binding domain-containing protein 3 is a protein that in humans is encoded by the LYSMD3 gene. This protein contains a LysM domain.
The conserved hydrophobic motif at the C-terminal extension of the kinase domain is bound to the N-terminal lobe of the kinase domain, despite being unphosphorylated.
The top-level domain .ee was introduced in 1992 and was operated by EENet until July 2010. The administrator of .ee domain was the academic Endel Lippmaa.
The .kiwi top level domain is not to be confused with .kiwi.nz, which launched as a new option under the .nz top level domain in August 2012.
Typically, the RPA proteins in Helitrons are 150 – 500-aa long and are encoded by several exons. In all Helitrons, the Rep domain precedes the Hel domain.
Specifically, this inhibition activates RAB2A, RAB8A, RAB10 and RAB14. AS160 also contains a calmodulin-binding domain, and this domain mediates phosphorylation- independent glucose uptake in muscle cells.
It admits the graph as fundamental domain. The graph of groups given by the stabiliser subgroups on the fundamental domain corresponds to the original graph of groups.
A domain holder may provide an infinite number of subdomains in their domain. For example, the owner of example.org could provide subdomains such as foo.example.org and foo.bar.example.
When the domain was merged with Obama Domain in 1870, he subsequently served as imperial governor of Obama until the abolition of the han system in 1871.
The Cob domain contains Cob sandwiched between several large alpha helices and bound to the enzyme so that the cobalt atom of the group is exposed for contact with other domains. The Hcy domain contains the critical zinc-binding site, made up of cysteine or histidine residues coordinated to a zinc ion that can bind Hcy, with an example from a non-Cob dependent MetH shown on the right. The N5-MeTHF binding domain contains a conserved barrel in which N5-MeTHF can hydrogen bond with asparagine, arginine, and aspartic acid residues. The entire structure undergoes a dramatic swinging motion during catalysis as the Cob domain moves back and forth from the Hcy domain to the Fol domain, transferring the active methyl group from the Fol to Hcy domain.
NACHT, LRR and PYD domains-containing protein 12 is a protein that in humans is encoded by the NLRP12 gene. NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine- rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).
The BHLHE41 protein has a myc-type, basic helix-loop-helix (bHLH) domain and an orange domain. The orange domain is a 30 residue sequence located on the carboxy-terminal end relative to the BHLH domain of the protein whose function is still unclear. The basic helix-loop-helix domain allows members of the protein family to dimerize with each other to affect gene transcription through binding to specific DNA sequences. BHLHE41 protein also has alanine and glycine-rich regions in the C-terminal, and lacks the WRPW motif for interaction with the corepressor Groucho.
In software engineering domain knowledge is knowledge about the environment in which the target system operates, for example, software agents. Domain knowledge usually must be learned from software users in the domain (as domain specialists/experts), rather than from software developers. It may include user workflows, data pipelines, business policies, configurations and constraints and is crucial in the development of a software application. Expert's domain knowledge (frequently informal and ill- structured) is transformed in computer programs and active data, for example in a set of rules in knowledge bases, by knowledge engineers.
Most TAAs have a similar protein structure. When observed with electron microscopy, the structure has been described as a "lollipop" shape consisting of an N-terminal head domain, a stalk domain, and a C-terminal membrane anchor domain. Often, the literature refers to these as Passenger domain, containing the N-terminal, head, neck, and coiled-coil stalk, and the Translocation domain, referring to the C-terminal membrane anchor. Although all TAAs carry a membrane anchor in common, they may not all contain both a stalk and a head as well.
A Windows domain is a form of a computer network in which all user accounts, computers, printers and other security principals, are registered with a central database located on one or more clusters of central computers known as domain controllers. Authentication takes place on domain controllers. Each person who uses computers within a domain receives a unique user account that can then be assigned access to resources within the domain. Starting with Windows Server 2000, Active Directory is the Windows component in charge of maintaining that central database.
DMARC (Domain-based Message Authentication, Reporting and Conformance) is an email authentication protocol. It is designed to give email domain owners the ability to protect their domain from unauthorized use, commonly known as email spoofing. The purpose and primary outcome of implementing DMARC is to protect a domain from being used in business email compromise attacks, phishing emails, email scams and other cyber threat activities. Once the DMARC DNS entry is published, any receiving email server can authenticate the incoming email based on the instructions published by the domain owner within the DNS entry.
PC1 interacts with polycystin 2 by a cytoplasmic coiled-coil domain. PC1 is a membrane-bound protein 4303 amino acids in length expressed largely upon the primary cilium, as well as apical membranes, adherens junctions, and desmosomes . It has 11 transmembrane domains, a large extracellular N-terminal domain, and a short (about 200 amino acid) cytoplasmic C-terminal domain . This intracellular domain contains a coiled-coil domain through which PC1 interacts with polycystin 2 (PC2), a membrane-bound Ca2+-permeable ion channel. PC1 has been proposed to act as a G protein–coupled receptor .
This hash harvesting technique is more advanced than previously used techniques (e.g. dumping the local Security Accounts Manager database (SAM) using pwdump and similar tools), mainly because hash values stored in memory could include credentials of domain users (and domain administrators) that logged into the machine. For example, the hashes of authenticated domain users that are not stored persistently in the local SAM can also be dumped. This makes it possible for a penetration tester (or attacker) to compromise a whole Windows domain after compromising a single machine that was a member of that domain.
NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene. NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine- rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).
Two functional domains were originally identified, including one which binds to syntaxin, but recent crystallization of the yeast homolog Sro7 revealed that tomosyn likely has three functional domains: one WD40 domain and one syntaxin-binding domain, as previously recognized, but also another WD40 domain. The study also suggested that tomosyn's 'syntaxin binding domain' is not the reason tomosyn is inhibitory for neurotransmitter release, as originally proposed. The Sro7-based structure is currently given on SWISS- MODEL, which includes the WD40 domains but not most of the coiled coil syntaxin-binding domain seen in the infobox.
Goi Domain was created on November 28, 1781, when Arima Ujiyoshi, the daimyō of Nishijo Domain in Ise Province relocated his jin'ya from Ise to Kazusa. He died two years later, at the age of 23, and his successors likewise had unusually short lifespans. His son Ujiyasu died at the age of 29, successor Hiroyasu at age 35 and son Ujisada at age 24. The 5th daimyō of Goi Domain, Arima Ujishige, decided to relocate his residence to Fukiage Domain in Kōzuke Province on April 17, 1842, and Goi Domain was thus dissolved.
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene. when found in humans. This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.
In molecular biology, the CRM domain is an approximately 100-amino acid RNA- binding domain. The name CRM (chloroplast RNA splicing and ribosome maturation) has been suggested to reflect the functions established for four characterised members of the family: Zea mays (Maize) CRS1, CAF1 and CAF2 proteins and the Escherichia coli protein YhbY. Proteins containing the CRM domain are found in eubacteria, archaea, and plants. The CRM domain is represented as a stand-alone protein in archaea and bacteria, and in single- and multi-domain proteins in plants.
There is significant variation among mammals, marsupials, and monotremes as to where the DUF383 domain begins, whereas this variation is smaller in reptiles, amphibians, fish, invertebrates, plants, and fungi. Additionally, the DUF383 domain ends at the same location for all homologs, while the DUF384 domain starts and ends at roughly the same location in all homologs. There is high homology in the DUF384 domain (292..349) and in the DUF383 domain (154..288), and several amino acids are completely conserved in vertebrates, invertebrates, plants, and fungi, which include Arg190, Gly219, Asn226, Lys273, and Lys338.
Angiotensin I is mainly hydrolyzed by the C-domain in vivo but bradykinin is hydrolyzed by both active sites. Thus, by developing a C-domain selective inhibitor would permit some degradation of bradykinin by the N-domain and this degradation could be enough to prevent accumulation of excess bradykinin which has been observed during attacks of angioedema. C-domain selective inhibition could possibly result in specialized control of blood pressure with less vasodilator-related adverse effects. N-domain selective inhibitors on the other hand give the possibility of opening up novel therapeutic areas.
Concepts of the model include: ;Context: The setting in which a word or statement appears that determines its meaning; ;Domain: A sphere of knowledge (ontology), influence, or activity. The subject area to which the user applies a program is the domain of the software; ;Model: A system of abstractions that describes selected aspects of a domain and can be used to solve problems related to that domain; ;Ubiquitous Language: A language structured around the domain model and used by all team members to connect all the activities of the team with the software.
In molecular biology, the BAH domain (bromo-adjacent homology) domain is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases, the origin recognition complex 1 (Orc1) proteins, Bromo adjacent homology domain containing 1 (BAHD1), as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH domain might therefore play an important role by linking DNA methylation, replication and transcriptional regulation.
Angiotensin-converting enzyme 2 is a zinc-containing metalloenzyme located on the surface of endothelial and other cells. ACE2 protein contains an N-terminal peptidase M2 domain and a C-terminal collectrin renal amino acid transporter domain. ACE2 is a single- pass type I membrane protein, with its enzymatically active domain exposed on the surface of cells in the lungs and other tissues. The extracellular domain of ACE2 is cleaved from the transmembrane domain by another enzyme known as sheddase, and the resulting soluble protein is released into the bloodstream and ultimately excreted as urine.
The Fourier transform relates the function in the time domain, shown in red, to the function in the frequency domain, shown in blue. The component frequencies, spread across the frequency spectrum, are represented as peaks in the frequency domain. Time domain refers to the analysis of mathematical functions, physical signals or time series of economic or environmental data, with respect to time. In the time domain, the signal or function's value is known for all real numbers, for the case of continuous time, or at various separate instants in the case of discrete time.
The BTB/POZ domain is a common structural domain contained within some proteins. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger proteins and in proteins that contain the Kelch motif and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer.
The second group consists of only the Caenorhabditis elegans protein zyg-9, which has three TOG domains. It is similar, though, to higher eukaryotes because of its variable region and C-terminal domain. The third group consists of lower eukaryotic organisms, mainly yeast, that contain only two TOG domains and a coiled-coil domain. The TOG3 domain in C. elegans zyg-9 Thorough analysis of the TOG3 domain in zyg-9 provides a basic understanding of this domain that is conserved throughout all members of the XMAP215/Dis1 family.
CDD content includes NCBI manually curated domain models and domain models imported from a number of external source databases (Pfam, SMART, COG, PRK, TIGRFAMs). What is unique about NCBI-curated domains is that they use 3D-structure information to explicitly define domain boundaries, align blocks, amend alignment details, and provide insights into sequence/structure/function relationships. Manually curated models are organized hierarchically if they describe domain families that are clearly related by common descent. To provide a non-redundant view of the data, CDD clusters similar domain models from various sources into superfamilies.
The ruling prompted what was widely called a "backlash" against this kind of eminent domain activity. In 2006 (on the first anniversary of the Kelo ruling), President George W. Bush issued an executive order limiting how federal agencies could use eminent domain. Between the Kelo ruling and June 2008, 37 states passed laws to increase restrictions on the use of eminent domain. In 2006, the organization won an eminent domain case in the Ohio Supreme Court, the first eminent domain decision by a state supreme court after Kelo.
The oxidoreductase FAD-binding domain is an evolutionary conserved protein domain. To date, the 3D-structures of the flavoprotein domain of Zea mays nitrate reductase and of pig NADH:cytochrome b5 reductase have been solved. The overall fold is similar to that of ferredoxin:NADP+ reductase: the FAD- binding domain (N-terminal) has the topology of an anti-parallel beta-barrel, while the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet flanked by 2 helices on each side).
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling.
The domain model in Grails is persisted to the database using GORM (Grails Object Relational Mapping). Domain classes are saved in the `grails-app/domain` directory and can be created using the `grails` command as shown below: grails create-domain-class Book This command requests the domain class name and creates the appropriate file. Below the code of the `Book` class is shown: class Book { String title Person author } Creating this class is all that is required to have it managed for persistence by Grails. With Grails 0.3, GORM has been improved and e.g.
The secondary market for domain names covers previously registered domain names that have not been renewed by registrants or are available for resale. Sometimes these dropped domain names can be more valuable due to their having had high-profile websites associated with them. They will have links from other websites and could still have users searching for the websites because of these links. Others can be valuable because of the generic nature of the domain name or the length of the domain name, with two and three character names being the most sought after.
This gene is a member of the Shank gene family. The gene encodes a protein that contains 5 interaction domains or motifs including the ankyrin repeats domain (ANK), a src 3 domain (SH3), a proline-rich domain, a PDZ domain and a sterile α motif domain (SAM). Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein- coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation.
The protein encoded by SLC25A12, Aralar1, is a mitochondrial calcium-binding carrier that facilitates the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. Aralar binds to one calcium ion with high affinity. Upon calcium binding, the EF-hand-containing regulatory N-terminal domain binds to the C-terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain. In the absence of calcium, the linker loop domain may close the vestibule, which may prevent substrates from entering the carrier domain.
Example of Greek IDN with domain name in non-Latin alphabet: ουτοπία.δπθ.gr An internationalized domain name (IDN) is an Internet domain name that contains at least one label that is displayed in software applications, in whole or in part, in a language-specific script or alphabet, such as Arabic, Chinese, Cyrillic, Devanagari, Hebrew or the Latin alphabet-based characters with diacritics or ligatures, such as French. These writing systems are encoded by computers in multibyte Unicode. Internationalized domain names are stored in the Domain Name System (DNS) as ASCII strings using Punycode transcription.
"" domain has one specific advantage – it is one of two domains in Europe (both operated by Serbian Domain Authority - RNIDS) that allows website addresses to be written exactly the way they are pronounced (some Arabic and the Korean domain also allow that). Thanks to the characteristic of the Serbian Cyrillic alphabet where each phoneme has its own letter-counterpart, the .СРБ and also .RS domain name addresses – as opposed to the multitude of domain names written in the English alphabet – are unequivocally pronounced exactly the way they are written.
One drawback of using source-synchronous clocking is the creation of a separate clock-domain at the receiving device, namely the clock-domain of the strobe generated by the transmitting device. This strobe clock-domain is often not synchronous to the core clock domain of the receiving device. For proper operation of the received data with other data already present in the device, an additional stage of synchronization logic is required to transfer the received data into the core clock-domain of the receiving device. This stage can often be found alongside source synchronous logic.
DEP, which is in C-terminal domain of DVL, has 75 amino acids in the human DVL proteins, and has three α-helices, a β-hairpin arm, and two short β-strands. This domain enables interaction between DVL and DAAM1, thus activating the non-canonical pathway. This domain also has results that support claims that the DEP domain is what is responsible for targeting DVL proteins to the membrane upon Wnt signal stimulation. The DEP domain may also be essential for the assembly of functional signalosomes and for Wnt signal transduction to the nucleus.
Satake Yoshimasa was the eldest son of Satake Yoshikata of Kubota-Shinden Domain and was adopted as heir to Satake Yoshizumi in 1742. He was received in formal audience by Shōgun Tokugawa Yoshimune in 1744, and became daimyō of Kubota in 1749. In 1751, he married Gōhime (1737-1762), the daughter of Maeda Yoshinori of Kaga Domain and he made his first visit to his domain the same year. Kubota Domain was rent by peasant uprisings and by plots among his retainers caused by the years of mismanagement of the domain by his predecessor.
Since domain ontologies are written by different people, they represent concepts in very specific and unique ways, and are often incompatible within the same project. As systems that rely on domain ontologies expand, they often need to merge domain ontologies by hand-tuning each entity or using a combination of software merging and hand-tuning. This presents a challenge to the ontology designer. Different ontologies in the same domain arise due to different languages, different intended usage of the ontologies, and different perceptions of the domain (based on cultural background, education, ideology, etc.).
Search Engine Optimization has put pressure on individuals and companies to consider how accurate domain names relate to their content. Therefore, they need to make sure their domain name closely relate to the content presented; allowing researchers to put the least possible energy and resources into quickly finding domain names with accurate information. Domain name auctions have become more popular when buyers and sellers are looking for specific domain names to achieve high Search Engine Optimization. Another factor why more and more people are purchasing expired domains is solely for the traffic they generate.
If a domain publishes an SPF record, spammers and phishers are less likely to forge emails pretending to be from that domain, because the forged emails are more likely to be caught in spam filters which check the SPF record. Therefore, an SPF-protected domain is less attractive to spammers and phishers. Because an SPF-protected domain is less attractive as a spoofed address, it is less likely to be denylisted by spam filters and so ultimately the legitimate email from the domain is more likely to get through.
Devices outside the collision domain do not have collisions with those inside. Only one device in the collision domain may transmit at any one time, and the other devices in the domain listen to the network and refrain from transmitting while others are already transmitting in order to avoid collisions. Because only one device may be transmitting at any one time, total network bandwidth is shared among all devices on the collision domain. Collisions also decrease network efficiency on a collision domain as collisions require devices to abort transmission and retransmit at a later time.
The kinase activity is inhibited by the intramolecular binding between the C-terminal cluster of RBD domain and the PH domain to the N-terminal kinase domain of ROCK. Thus, the kinase activity is off when ROCK is intramolecularly folded. The kinase activity is switched on when Rho-GTP binds to the Rho-binding domain of ROCK, disrupting the autoinhibitory interaction within ROCK, which liberates the kinase domain because ROCK is then no longer intramolecularly folded. Other regulators It has also been shown that Rho is not the only activator of ROCK.
There is also an inverse Fourier transform that mathematically synthesizes the original function from its frequency domain representation, as proven by the Fourier inversion theorem. Linear operations performed in one domain (time or frequency) have corresponding operations in the other domain, which are sometimes easier to perform. The operation of differentiation in the time domain corresponds to multiplication by the frequency,Up to an imaginary constant factor whose magnitude depends on what Fourier transform convention is used. so some differential equations are easier to analyze in the frequency domain.
Following the Battle of Sekigahara, in 1600, Tokugawa Ieyasu shifted the Satake clan from its ancestral territories in Hitachi Province to Dewa Province in northern Japan. In 1602, he awarded a portion of the former Satake lands to Tozawa Masamori, marking the start of Matsuoka Domain. He served in a number of important posts within the administration of the Tokugawa shogunate, and was subsequently transferred to Shinjō Domain in Dewa Province in 1622. Matsuoka Domain was divided, with 30,000 koku going to Mito Domain and 10,000 koku to Tanagura Domain.
This marked the start of Annaka Domain. After beginning work on Annaka Castle and the surrounding castle town, Naotsugu retired in favor of his son, Ii Naoyoshi, who was transferred to Nishio Domain in Mikawa Province in 1643. The Ii clan was replaced by Mizuno Mototsugu from Shinjō Domain in Mikawa, and the domain was reduced to 20,000 koku. He turned the domain over to his son Mizonu Mototomo in 1663; however after Mototomo went insane and attempted to murder his wife in 1667, he was relieved of his post.
Proof: In a Bézout domain the ACCP is equivalent to the ACC on finitely generated ideals, but this is known to be equivalent to the ACC on all ideals. Thus the domain is Noetherian and Bézout, hence a principal ideal domain. The ring Z+XQ[X] of all rational polynomials with integral constant term is an example of an integral domain (actually a GCD domain) that does not satisfy (ACCP), for the chain of principal ideals :(X) \subset (X/2) \subset (X/4) \subset (X/8), ... is non-terminating.
Generally, inflammasome-forming NLR proteins share a similar structure, several leucine-rich repeat (LRR) domains, a central nucleotide- binding and oligomerization domain (NBD) and an N-terminal pyrin domain (PYD). NLRP3, for example, recruits ASC adaptor protein via PYD-PYD interaction. Both pro-caspase-1 and ASC contain a caspase activation and recruitment domain (CARD), and this homotypic CARD-CARD interaction enables autocatalytic cleavage and reassembly of procaspase-1 to form active caspase-1. Alternatively, NLRC4 can directly recruit pro-caspase-1, as it has a CARD domain instead of a pyrin domain.
However, the SH2 domain of Jak3 prevented P-villin from binding to the FERM domain of nonphosphorylated protein. The intramolecular interaction between the FERM and SH2 domains of nonphosphorylated Jak3 prevented Jak3 from binding to villin and tyrosine autophosphorylation of Jak3 at the SH2 domain decreased these intramolecular interactions and facilitated binding of the FERM domain to villin. These demonstrate the molecular mechanism of interactions between Jak3 and cytoskeletal proteins where tyrosine phosphorylation of the SH2 domain acted as an intramolecular switch for the interactions between Jak3 and cytoskeletal proteins.
In molecular biology the LysM domain is a protein domain found in a wide variety of extracellular proteins and receptors. The LysM domain is named after the Lysin Motif which was the original name given to the sequence motif identified in bacterial proteins. The region was originally identified as a C-terminal repeat found in the Enterococcus hirae muramidase. The LysM domain is found in a wide range of microbial extracellular proteins, where the LysM domain is thought to provide an anchoring to extracellular polysaccharides such as peptidoglycan and chitin.
In IDEF5 the meaning of the term ontology is characterized to include a catalog of terms used in a domain, the rules governing how those terms can be combined to make valid statements about situations in that domain, and the “sanctioned inferences” that can be made when such statements are used in that domain. In every domain, there are phenomena that the humans in that domain discriminate as (conceptual or physical) objects, associations, and situations. Through various language mechanisms, one associates definite descriptors (e.g., names, noun phrases, etc.) to those phenomena.
ApoER2 is a protein made up of 870 amino acids. It is separated into a ligand binding domain of eight ligand binding regions, an EGF-like domain containing three cysteine-rich repeats, an O-linked glycosylation domain of 89 amino acids, a transmembrane domain of 24 amino acids, and a cytoplasmic domain of 115 amino acids, including an NPXY motif. alt=A diagram of the structure of APOER2 Each letter in the NPXY motif represents a certain amino acid where N is arginine, P is proline, X is any amino acid, and Y is tyrosine.
An HK is composed of several domains starting with a short N-terminal cytoplasmic portion connected to an extracellular sensing domain via a transmembrane α helix. A second transmembrane α helix connects the extracellular domain to the C-terminal cytoplasmic catalytic domain. HKs are known to serve roles in many different signal transduction pathways, so it is not surprising that the extracellular sensing domain is not very well conserved in the HK family. In contrast, the cytoplasmic domain tends to have high sequence homology and contains several well-known motifs.
Domain Group (or simply Domain) is an Australian digital property portal and associated real-estate industry business. The company was founded by Fairfax Media, when the publisher branded their real-estate sections in print with the Domain brand and first established an online presence in 1999. The company was a wholly owned subsidiary of Fairfax until November 2017, when Domain was listed on the Australian Stock Exchange as a public company, although Fairfax Media (now Nine) retained a 60% ownership of shares. The Domain Group is best known for its real-estate portal domain.com.
The lumen-side segment of cyt f includes two structural domains: a small one above a larger one that, in turn, is on top of the attachment to the membrane domain. The large domain consists of an anti-parallel beta-sandwich and a short haem-binding peptide, which form a three-layer structure. The small domain is inserted between beta-strands F and G of the large domain and is an all-beta domain. The haem nestles between two short helices at the N terminus of cyt f.
Domain info has been operated by Afilias since its creation. In 2003, it was the first gTLD domain to support IETF standards-based internationalized domain names.INFO internationalized domain names In 2001, Afilias CTO (Ram Mohan) discovered problems with the Universal Acceptance of the domain due to it being the first tld whose length was greater than two or three characters. The launching of info involved a "Sunrise Period" for trademark owners, followed by a "landrush" open to all, the first time such a process had ever been conducted for a new gTLD.
In the Edo period, it was nominally part of Odawara Domain, although large portions were tenryō territory controlled by the shōgun in Edo through various hatamoto. From 1706, a branch of the Ōkubo clan in Odawara was permitted to establish the Ogino- Yamanaka Domain on a portion of the district. Other portions of the district came under control of Karasuyama Domain of Shimōsa Province. With the Meiji Restoration of 1868, Ogino-Yamanaka Domain came under the control of Shizuoka Domain, while remaining territories became part of the new Kanagawa Prefecture.
The domain of function on this gene is known as the KRAB (Kruppel-associated box) domain - A box and it spans from amino acid 7 to 47. It is a transcription repression domain within the zinc finger proteins subgroup of the KRAB-ZFPs family. The KRAB domain interacts with and recruits other proteins and corepressors and then represses transcription. The mechanism appears to be the following: the KRBA proteins via their KRAB domain recruit the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein).
A DNS zone is any distinct, contiguous portion of the domain name space in the Domain Name System (DNS) for which administrative responsibility has been delegated to a single manager. The domain name space of the Internet is organized into a hierarchical layout of subdomains below the DNS root domain. The individual domains of this tree may serve as delegation points for administrative authority and management. However, usually it is furthermore desirable to implement fine-grained boundaries of delegation, so that multiple sub-levels of a domain may be managed independently.
The N-terminal domain is the carbamoyl phosphate binding domain. The C-terminal domain is an aspartate/ornithine-binding domain. Aspartate carbamoyltransferase (ATCase) catalyses the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate, the second step in the de novo biosynthesis of pyrimidine nucleotides. In prokaryotes ATCase consists of two subunits: a catalytic chain (gene ) and a regulatory chain (gene pyrI), while in eukaryotes it is a domain in a multi- functional enzyme (called URA2 in yeast, rudimentary in Drosophila, and CAD in mammals) that also catalyzes other steps of the biosynthesis of pyrimidines.
DHR2 ( _D_ OCK _h_ omology _r_ egion 2), also known as CZH2 or Docker2, is a protein domain of approximately 450-550 amino acids that is present in the DOCK family of proteins. This domain functions as a guanine nucleotide exchange factor (GEF) domain for small G proteins of the Rho family. DHR2 domains bear no significant similarity to the well described DH domain ( _D_ bl _h_ omologous domain) present in other RhoGEFs such as Vav, P-Rex and TRIO. Indeed, the most divergent mammalian DHR2 domains share only 16-17% sequence similarity.
350px A domain name is an identification string that defines a realm of administrative autonomy, authority or control within the Internet. Domain names are used in various networking contexts and for application-specific naming and addressing purposes. In general, a domain name identifies a network domain, or it represents an Internet Protocol (IP) resource, such as a personal computer used to access the Internet, a server computer hosting a website, or the web site itself or any other service communicated via the Internet. In 2017, 330.6 million domain names had been registered.
Registries and registrars usually charge an annual fee for the service of delegating a domain name to a user and providing a default set of name servers. Often, this transaction is termed a sale or lease of the domain name, and the registrant may sometimes be called an "owner", but no such legal relationship is actually associated with the transaction, only the exclusive right to use the domain name. More correctly, authorized users are known as "registrants" or as "domain holders". ICANN publishes the complete list of TLD registries and domain name registrars.
Registrant information associated with domain names is maintained in an online database accessible with the WHOIS protocol. For most of the 250 country code top-level domains (ccTLDs), the domain registries maintain the WHOIS (Registrant, name servers, expiration dates, etc.) information. Some domain name registries, often called network information centers (NIC), also function as registrars to end-users. The major generic top-level domain registries, such as for the com, net, org, info domains and others, use a registry-registrar model consisting of hundreds of domain name registrars (see lists at ICANN or VeriSign).
STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases. It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly. The protein consists of an N-terminal sterile alpha motif (SAM) domain, a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).
Domain knowledge is knowledge of a specific, specialized discipline or field, in contrast to general knowledge, or domain-independent knowledge. The term is often used in reference to a more general discipline, as, for example, in describing a software engineer who has general knowledge of programming, as well as domain knowledge about the pharmaceutical industry. People who have domain knowledge, are often considered specialists or experts in the field.
In March 2010, National Public Radio launched its own URL shortener under the domain using the ccTLD of Puerto Rico. The n.pr domain is currently used to link to an NPR story page by its ID and is one of the shortest possible domain hacks. In late 2010, Apple launched a URL shortener at the domain , using the ccTLD of Spain, in a similar move to Google's goo.gl.
The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin.
A Noetherian integral domain is a UFD if and only if every height 1 prime ideal is principal (a proof is given at the end). Also, a Dedekind domain is a UFD if and only if its ideal class group is trivial. In this case it is in fact a principal ideal domain. In general, the following conditions of the integral domain A are equivalent: # A is a UFD.
The Laplace transform is often used in circuit analysis, and simple conversions to the -domain of circuit elements can be made. Circuit elements can be transformed into impedances, very similar to phasor impedances. Here is a summary of equivalents: : -domain equivalent circuits Note that the resistor is exactly the same in the time domain and the -domain. The sources are put in if there are initial conditions on the circuit elements.
Cytochrome c binds to the WD-40 domain of Apaf-1. This allows for the "lock" to be released, meaning this domain is no longer autoinhibited. However, the CARD and NB-ARC domains remain in autoinhibited state. The CARD domain will only be released from this lock when Apaf-1 is bound to (d) ATP/ATP; when ATP binds, the CARD domain will then be allowed to bind to Caspase-9.
Tat contains a protein transduction domain, which is therefore known as a cell-penetrating peptide. Originally characterised by Frankel and Pabo (1988) and Green and Loewenstein (1988), this domain allows Tat to enter cells by crossing the cell membrane. The amino acid sequence of the protein transduction domain is YGRKKRRQRRR. The nuclear localisation signal found within the domain, GRKKR, mediates further translocation of Tat into the cell nucleus.
The use of the contrasting terms time domain and frequency domain developed in U.S. communication engineering in the late 1940s, with the terms appearing together without definition by 1950. When an analysis uses the second or one of its multiples as a unit of measurement, then it is in the time domain. When analysis concerns the reciprocal units such as Hertz, then it is in the frequency domain.
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.

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