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75 Sentences With "danger signal"

How to use danger signal in a sentence? Find typical usage patterns (collocations)/phrases/context for "danger signal" and check conjugation/comparative form for "danger signal". Mastering all the usages of "danger signal" from sentence examples published by news publications.

"Maritime ports of Chittagong and Cox's Bazar have been advised to lower danger signal number seven but instead hoist great danger signal number ten (repeat) ten," a government weather bulletin said.
Two red flags are a danger signal, alerting people to take shelter in their homes.
In the right-hand panel, a crimson escutcheon hovers, like a danger signal, against a vortex of tangled, scribbled lines.
"We heard nothing of any kind of an attempted overtaking maneuver, warning, or danger signal on the radio," Zoltan Tolnay said.
As two of the Iranian vessels continued to barrel toward the Nitze at high speed, the destroyer used an internationally recognized maritime danger signal three times.
You can assume that the central banks are leaning artificially on the long-term end of the curve, and the curve is still a danger signal.
The report attributes the collision to failure to maneuver the ship away from the approaching freighter, failure to sound the danger signal and failure to try to contact the Crystal.
"It was a danger signal for RCA stock in 1929, the Nifty Fifty stocks in the 1960s, oils in 1981, tech stocks in 1999 and banks in 2005," he said.
In another danger signal for Trump, the poll asked "how confident are you that the vaccine will be available to the American public at little or no cost" if a Democrat wins or if Trump is re-elected.
In another danger signal for Trump, the poll asked "how confident are you that the vaccine will be available to the American public at little or no cost" if a Democrat wins or if Trump is re-elected.
DHAKA/AGALAWATTE, Sri Lanka/ (Reuters) - Bangladesh raised its storm danger signal to the highest level of 22004 on Monday as a severe and intensifying cyclone churned toward its low-lying coast and was expected to make landfall in the early hours of Tuesday.
"The officer of the deck, the person responsible for safe navigation of the ship, exhibited poor seamanship by failing to maneuver as required, failing to sound the danger signal and failing to attempt to contact Crystal on bridge-to-bridge radio," November's report reads.
In plants, danger signal sensors have been identified to contain many NALPs and therefore it is proposed that NALPs can also serve as danger signal sensors.
In Chennai, all schools and colleges were closed as 282 schools and 52 community hallwereve been converted into cyclone shelters. Danger signal 7 was hosted in Chennai, Ennore, Cuddalore and Nagapattinam ports of Tamil Nadu and in Puducherry, and danger signal 3 in Krishnapatnam, Vadarevu, Machilipatnam and Nizampatnam ports of Andhra Pradesh.
This allows the cell to have varying degrees of inflammatory responses based on the severity of the danger signal received.
Danger Signal is a 1945 film noir starring Faye Emerson and Zachary Scott. The screenplay was adapted from the novel of the same name by Phyllis Bottome.
The Danger Signal, Canavan, the Man Who Had His Way or Caravan is a 1915 American drama silent black and white film directed by Walter Edwin and produced by George Kleine. It is based on the story of Rupert Hughes.
New York Times 12 Nov 1944: X3. The cast also included Dan Duryea and Ralph Bellamy, who was borrowed from Hunt Stromberg.SCREEN NEWS: Faye Emerson Gets Lead in 'Danger Signal' Special to THE NEW YORK TIMES.19 Jan 1945: 25.
The Ministry of Transport report found that he had failed to slow down after passing two caution signals, so he was unable to stop at the danger signal, concluding that the use of an Automatic Warning System would have prevented the collision.
Similarly, adenosine triggers degranulation through P1 receptors. Uric acid is also an endogenous danger signal released by injured cells. Adenosine triphosphate (ATP) and uric acid, which are purine metabolites, activate NLR family, pyrin domain containing (NLRP) 3 inflammasomes to induce IL-1β and IL-18.
Whilst the ideal safety system would prevent a SPAD from occurring, most equipment in current use does not stop the train before it has passed the Danger signal. However, provided that the train stops within the designated overlap beyond that signal, a collision should not occur.
In April 1944, he was burned when his car was on fire."Allies Capture Jap Positions Near Kohima". Los Angeles Times April 29, 1944: 2. Back at Warners Florey directed God Is My Co-Pilot (1945) with Morgan, and Danger Signal (1945) with Emerson and Zachary Scott.
On 31 December 1945, two Metropolitan line trains collided in fog on an open-air section near Northwood. The driver of the second train had passed a danger signal under the "Stop and Proceed" rule but did not see the preceding train soon enough to stop. A fire was started by electrical arcing. 3 people were killed.
Jersey Lilly historical marker In 1890, Bean received word that railroad developer and speculator Jay Gould was planning to pass through Langtry on a special train. Bean flagged down the train using a danger signal. Thinking the bridge was out, the train engineer stopped the train. Bean then invited Gould and his daughter to visit the saloon as his guests.
Baker was charged with four counts of negligence--that he had not used caution in navigation, that he had not yielded to another ship, that he had not reduced speed when approaching another ship, and that he had not sounded a danger signal. His hearing was adjourned until September to allow time to prepare a defense. On September 12, eight further charges of negligence relating to Baker's actions after the collision were brought, and his hearing was therefore delayed again until the end of September. On August 3, pilot Patrick Kelly, who was in command of Texaco Massachusetts, was charged with four counts of negligence--failure to use caution in navigating, failure as a "privileged vessel" to maintain course and speed, failure to sound a danger signal, and failure to sound a signal indicating his ship was reversing.
Alone at the house, Evelyn goes into labor. While making her way to their basement, she accidentally steps on an exposed nail with her right foot. In pain, Evelyn accidentally drops a glass picture frame and alerts a nearby creature. Evelyn flips a switch that changes the exterior house lights to red as a danger signal to the others and struggles to remain silent during her contractions.
The chief engineer then ordered the engineering crew members to brace themselves for the collision. Up in the pilothouse, the Captain began to sound the whistle and issue the danger signal. The mate issued a brace command over the vessel's public address system and deckhands began to move passengers away from the vessel's bow. At 0918:33, Andrew J. Barberi forcefully collided with the terminal.
PEPR 1 and PEPR2 (Perception of the Arabidopsis Danger Signal Peptide 1 or 2) are homolog kinases that act as enzymes on other proteins. They attach a phosphate group to specific proteins, called phosphorylation. These reactions can cause the function of the phosphorylated proteins to change. Both PEPR 1 and PEPR 2 can be classified as receptor kinases, which serve an important role in immunity in plants.
Prince Azim learns of the ambush. When he is unable to convince the governor, he chooses to risk his own life to warn his friends. After Azim leaves for home, the governor receives confirmation of the plot and sends four battalions to the rescue. Azim manages to warn Carruthers of the impending massacre by playing a danger signal on the "Sacred Drum of Tokot", saving many British lives.
A member of the New York Public Service Commission stated "The railroad rules are very strict. The engineers are required to know the location of every signal. That is part of their business. It is their duty to observe every signal, if for any reason, they cannot or do not see it as the train passes, it is their duty to regard it as a danger signal and stop the train".
The passenger train passed Paddock Wood at , which was minutes ahead of schedule. At that time, the parcels train was occupying track circuit FH. Signal PE129 was showing line clear. The passenger train cleared track circuits FF and FG, and entered track circuit FH which was still occupied by the parcels train. The signalman at Ashford sent the "obstruction danger" signal to Tonbridge signal box at 20:42.
Eventually, he became a nationally known talent and traveled with a number of different acts, including The Two Johns, A Tin Soldier, and The Danger Signal, among others. Dresser wrote songs featured in these shows, sold his songs to others acts, and published his music. In 1893 Dresser joined "Howley, Haviland and Company", a New York City sheet music publisher, as a silent partner. He later became an active partner in other music publishing companies.
Hughes and Meyer provided the funding and airplanes for the wedding. When Roosevelt went back to Europe, he named his reconnaissance aircraft "My Faye". After some months in Beverly Hills in 1945, the couple resided with Eleanor Roosevelt at Hyde Park, New York. Emerson continued to appear in a number of crime dramas, co-starring with Zachary Scott in three: The Mask of Dimitrios (1944), Danger Signal (1945), and Guilty Bystander (1950).
Large increases in extracellular ATP that are associated with cell death serve as a "danger signal" in the inflammatory processes. In neutrophils, tissue adenosine can either activate or inhibit various neutrophil functions, depending on the inflammatory microenvironment, the expression of adenosine receptors on the neutrophil, and the affinity of these receptors for adenosine. Micromolar concentrations of adenosine activate A2A and A2B receptors. This inhibits the release of granules and prevents oxidative burst.
On 1 December 1956 five people were killed and 100 injured. This accident occurred when the 'Westlander' crashed into the 'Western Mail' at Wallumbilla, near Roma, SW Qld (467 km west of Brisbane). The two trains were intended to cross at the station. However, the 345-tonne Westlander passed through a danger signal without slowing and hit the 200-tonne mail train head-on, pushing it back 46 metres, and derailing both engines and many carriages.
In 1892 Frank Shuman invented wire glass safety glass.Patent number: 483021 Additional patents were issued relating to the process of making wire glass and machines for making wire glass. In 1914 Shuman invented a process for making laminated safety glass, called safety glass, and manufactured by the Safety Glass Company. In 1916 he patented a "Danger Signal" for railroad crossings,Patent number: 1420345 as well as the use of liquid oxygen or liquid air to propel a submarine.
Pyroptosis acts as a defence mechanism against infection by inducing pathological inflammation. The formation of inflammasomes and the activity of caspase-1 determine the balance between pathogen resolution and disease. In a healthy cell, caspase-1 activation helps to fight infection caused by Salmonella and Shigella by introducing cell death to restrict pathogen growth. When the "danger" signal is sensed, the quiescent cells will be activated to undergo pyroptosis and produce inflammatory cytokines IL-1β and IL-18.
The terms "on" and "off" are used in describing British railway signals. When describing an older semaphore, "on" refers to a signal arm in the horizontal position, and "off" means a signal raised upwards or lowered downwards from pivot point (at up to 60°). With regard to newer colour-light signals, "on" is synonymous with a danger signal, while all other aspects are considered to be "off". A way to remember this is to refer to the state of the red light.
He tried to contact the Centralised Traffic Control Office at George Goch via radio, but the communications systems were out of service at the centre due to a power failure. Meanwhile, the following train was travelling over the speed limit at about in a zone. It failed to slow at a yellow caution signal nor stop at the red danger signal. The driver applied the brakes from the stopped train, but the train only slowed to at the point of impact.
With an extra stop, the trams take 23 minutes uphill and 24 minutes downhill. In August 1953, the Irk Valley Junction rail crash occurred on the line near Manchester Victoria, resulting in ten deaths and 58 injuries. It was caused by an electric train overrunning a danger signal which collided with a steam train, resulting in the front carriage of the electric train crashing into the River Irk. The original station was closed in 1980 and replaced by the new, more conveniently located Bury Interchange.
The competent, efficient doctors and nurses gave good medical care but seemed unaware of the suffering around them. They saw that children initially protested at separation from the parents, but then settled, becoming quiet and compliant. However, Robertson saw this as a danger signal. Based on several years of observations in long and short stay wards, Bowlby and Robertson formed a theory of phases of response of the under 3's to a stay in hospital without the mother: Protest, Despair and Denial/Detachment.
If the first train was delayed by engine failure or otherwise, the guard would go back down the track and exhibit a hand danger signal to any following train. The time interval was intended to give the guard time to do so. The system was very uncertain in operation and was (much later) superseded by the block system, in which a train may not enter a specified section of line (a "block") until it was known that the preceding train had left it. This required telegraphic communication between the stations.
These IgA deposits may disappear after long-term (up to ten years) avoidance of dietary gluten. Gliadin proteins in gluten are absorbed by the gut and enter the lamina propria where they need to be deamidated by tissue transglutaminase (tTG). tTG modifies gliadin into a more immunogenic peptide. Classical dendritic cells (cDCs) endocytose the immunogenic peptide and if their pattern recognition receptors (PRRs) are stimulated by pathogen-associated molecular patterns (PAMPs) or danger- associated molecular pattern (DAMPs), the danger signal will influence them to secrete IL-8 (CXCL8) in the lamina propria, recruiting neutrophils.
Standard British three position lower quadrant semaphore signals, with an arm for each direction and spectacles mounted below them, were used from the introduction of time-interval working in 1855. The last signal of this type was removed from Girilambone in 1952. The Danger signal was given by a horizontal arm and red light during darkness. The arm was lowered 45 degrees, with a green light for Caution, to "slacken speed", and to an almost vertical position in a slotted post with a white light for All Right.
More conventional semaphore signals replaced the discs and crossbars over time. The GWR persisted with the lower quadrant form, where a "proceed" aspect is indicated by lowering the signal arm, despite other British railways changing to an upper quadrant form. Electric light signals of the "searchlight" pattern were later introduced at busy stations; these could show the same red/green or yellow/green aspects that semaphore signals showed at night. An "automatic train control" system was introduced from 1906 which was a safety system that applied a train's brakes if it passed a danger signal.
In the film he portrays Joan Crawford's somewhat sleazy love interest, whose mysterious murder forms the basis of the plot. (In the novel on which the movie is based, the character is just as sleazy but is not killed.) Scott co-starred with Faye Emerson in Danger Signal (1945) and was with Janis Paige and Dane Clark in Her Kind of Man (1946). In 1946 exhibitors voted Scott the third most promising "star of tomorrow". During this period, Scott and his first wife Elaine socialized regularly with Angela Lansbury and her first husband, Richard Cromwell.
The Pakistan Meteorological Department issued a report calling for "danger preparedness" in the coastal regions in danger during the day on November 12. As the storm neared the coast, a "great danger signal" was broadcast on Pakistan Radio. Survivors later said that this meant little to them, but that they had recognised a No. 1 warning signal as representing the greatest possible threat. Following two previously destructive cyclones in October 1960 which killed at least 16,000 people in East Pakistan, the Pakistani government contacted the American government for assistance in developing a system to avert future disasters.
Plasma gelsolin binds and severs filamentous actin exposed from cells damaged by injury, including both infectious and sterile injury. Actin has been reported to activate platelets, interfere with fibrinolysis, damage endothelial cells, and to function as a danger signal (DAMP). Administration of large quantities of filamentous actin to rats resulted in lethal pulmonary hemorrhage and thrombosis. Another key “toxicity” of exposed actin is the fact that it is a major component of biofilms that accumulate at local sites of injury and infection and that it impedes the access of host immune components and therapeutics such as antibiotics.
When deprived of control an individual will process information in a more systematic manner. Through giving subjects Through giving subjects unsolvable problems to create a control deprived situation, followed by needing to pair words from sentences after a waiting period. Subjects from the experimental group were able to better recognise previously paired sentences as well as facts and make judgements on texts. The authors explore that these results highlight that failing to control outcomes is a built-in danger signal leading to a greater focus. The discussion moves onto these implications in motivation tools and how to “get the most” out of someone.
Henderson, On the Banks of the Wabash, p. 115. Dresser, who had been large since his youth and weighed nearly , performed as a jolly plumber in the nationally acclaimed show.Henderson, "On the Banks of the Wabash", p. 119–21. "Days Gone By" and other Dresser songs were included in the show.Henderson, On the Banks of the Wabash, p. 122 and 124. He began to have a dispute with Hoyt over the use of his songs, and Hoyt's refusal to acknowledge him as the composer. Dresser left the act in April 1891 and traveled the country performing in The Danger Signal.
In the evening of 19 April 1943, three poorly armed members of the resistance attacked the railway convoy as it passed near Haacht in Flemish Brabant. The train, containing over 1,600 Jews, was guarded by 16 Germans from the . Resistance members used a lantern covered with red paper (a danger signal) to stop the train, and freed 17 prisoners from one wagon before they were discovered by the Germans. A further 200 managed to jump from the train later in the journey, as the train's Belgian driver deliberately kept his speed low to allow others to escape.
Heat shock proteins (HSPs) are present in some bacteria and serve as a "danger signal" to the immune system. However, some HSPs share a similarity in bacteria and humans. The anti-HSP60 and anti-HSP65 antibodies that target HSPs produced by Streptococci (including S. sanguinis and S. pyogenes) and Mycobacterium tuberculosis can also target human HSPs, leading to immune responses linked to uveitis and various symptoms shown in parenchymal neuro-Behçet's disease. An association with the GIMAP ("GTPase of the immunity-associated protein") family of genes on the long arm of chromosome 7 (7q36.1) has been reported.
Blackwell, Oxford. pp. 8-9. ::The Ballad of the Veliger or How the gastropod got its twist > The Veliger's a lively tar, the liveliest afloat, > A whirling wheel on either side propels his little boat; > But when the danger signal warns his bustling submarine, > He stops the engine, shuts the port, and drops below unseen. > He's witnessed several changes in pelagic motor-craft; > The first he sailed was just a tub, with a tiny cabin aft. > An Archi-mollusk fashioned it, according to his kind, > He'd always stowed his gills and things in a mantle-sac behind.
Memorial to the train crash on the wall of the station The Ministry of Transport report on the collision was published in 1958. Witnesses were interviewed, the visibility of the signals on the line examined, and tests showed no fault in the signalling equipment. The report found that the driver had not slowed for two caution signals, and applied the brakes only after the fireman had called to him that he had passed a danger signal. Although he had poor visibility of signals from the driver's seat, he did not cross over to see them, or ask the fireman to look for them.
MHC class I polypeptide–related sequence A (MICA) is a highly polymorphic cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and it has similar domain structure, however, it is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do. MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D"). MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface and which are activated via this interaction.
The incident occurred when the driver, meaning to back the train up to Sheung Shui station, failed to follow a speed/stop signal while the train was exceeding the speed limit. The train was being driven from the rear cabin, with the driver relying on signals from the train guard who was in the front carriage. The train sped past a danger signal onto a siding at 30 km/h, rather than shunting onto the main line at 10 km/h as it was meant to. It crashed into a concrete buffer at the end of the siding, with the first two cars piling on top of each other.
Speaking to The Hindu, the guard of the Hampi Express, Bhagwan, said he had no clue that the train had actually jumped a danger signal that denied entry into Penukonda station. He said that he was among the first to run into the station for help and denied rumours that himself or the pilots tried to escape. Meanwhile, experts in the signalling system for the railways at Guntakal said an enquiry into the incident would bring out the truth. They denied any possibility of the driver having been under the influence of alcohol, as all pilots were subjected to a breathalyser test and that unless they passed it, they would not be allowed for duty.
The exceptions are illustrative in that they show that regulatory T cells can also act as helper T cells for immune responses in the gut and mucosal tissue. Matzinger argues that their function is to maintain the right kinds of immune responses in the right places, and that they are controlled by signals from the tissues that they protect. A student sitting in an immunology class today will likely hear many phrases coined by Matzinger, such as "professional antigen-presenting-cell", "danger signal", or "DAMPs", but will often hear them in the framework of a self/non- self explanation of immunity. Other immunologists have often adapted parts of Matzinger's ideas without adopting the danger model as a theoretical framework.
The parcels train had reached a maximum speed of when it was hit from the rear by the passenger train at a closing speed of between and , having passed signal A322 at caution and signal A324 at danger. Signal A370 was still showing proceed as the parcels train had not reached track circuit FH, which controlled that signal. The leading carriage of the passenger train was derailed to the left, and rolled down the embankment ending up upside down at a point some beyond the point of the collision. The second carriage ended up on its left side between the wreckage of the first carriage and the railway, and slightly ahead of it.
At 3:00am local time on 2 October 2010, an Argo Bromo Anggrek executive train travelling from Jakarta to Surabaya ran into the rear of a Senja Utama Semarang business train at Petarukan, Pemalang a city on the north coast of central Java. The Argo Bromo executive train had 336 passengers on board, while the Senja Utama Semarang business train was bound for Semarang and carrying 663 passengers. The location of the crash was at track 4 of Petarukan station. The Argo Bromo Anggrek train was supposed to pass the slower Senja Utama Semarang train (which was waiting to be passed at track 4), on track 3, but it passed a danger signal and eventually rear-ended the waiting train.
The enquiry concluded with a response to press suggestions that "some mechanical contrivance working in conjunction with the semaphore signals should be adopted, to render it impossible for a driver to pass a danger signal without becoming aware of the fact". It warned that the introduction of such a system would lead drivers to rely on it, so paying less heed to the signals themselves. At the time of the accident several such systems were under consideration by railway companies but had "not yet emerged from the experimental stage". As a result of this accident the Great Western Railway worked to introduce by 1908 a system of Automatic Train Control in which a horn was sounded on the footplate when a Distant signal was passed at caution.
The railway itself was constructed through the locality in 1859 but the Motspur Park station was not added until 1925. On 6 November 1947, there was a train crash at Motspur Park junction, south of the station which killed four and injured 12 people. In foggy conditions, a train was incorrectly authorized by a fogsignalman to pass a danger signal, and collided with another train that was crossing the line in front of it. A small newspaper kiosk once stood on the West Barnes Lane side of the approach road, Station Road, opposite the Earl Beatty public house, but this was demolished in the 1970s and has been replaced by a prefabricated travel agency office that later became a minicab office.
Before the Ministry of Transport report was published, Robert Morgan – the driver of the Littlehampton train – pleaded guilty to manslaughter and was sentenced to 12 months in prison plus six months suspended. The report, published in 1989, found no fault in the Littlehampton train or signalling system, and concluded that the driver had failed to keep the train's speed under control, missing the preceding caution signal and passing the danger signal protecting the Horsham train. The line is equipped with four aspect colour light signalling and British Rail's Automatic Warning System (AWS). However the report noted that the signal had a high incidence of being passed at danger – four drivers had previously passed the signal when at danger in the previous five years.
Safety engineers, who were part of the rescue special that steamed in from Bangalore to Penukonda in the wake of the accident, said the loss of lives could have been avoided if only the loco pilot had been alert. Under such circumstances, the loco pilot should not have overlooked the danger signal that denied him entry to the station until the goods train moved out of Penukonda railway station, said experts after a preliminary examination of the accident spot. Nevertheless, M.Y. Ratnam, a loco pilot with the South Central Railway's Guntakal zone, and co-pilot Balaraju escaped, probably because they jumped out of the train immediately after applying the emergency brake. Had they not applied the brake, the impact of the collision would have spread to more coaches increasing the toll, the safety engineers said.
The Thameslink train was approaching London Bridge from New Cross Gate on the Up Fast line of the Brighton Main Line, and had been signalled to cross on to the Up Passenger Loop of the South Eastern Main Line at Spa Road junction.Quail Map 5 – England South [page 3] Sept 2002 (Retrieved 22 December 2011) The Connex South Eastern train was approaching Spa Road from New Cross and had received the correct signalling sequence of a Preliminary Caution (two yellow aspect signal) and Caution (single yellow aspect signal) prior to L154 (the signal protecting the junction) being at Danger. However the driver did not respond to the signals and failed stop his train at the Danger signal, continuing until his train collided with the Thameslink train at the trailing points.
The Southall rail crash would not have been prevented by TPWS, but could have been prevented by ATP (ironically fitted but not in use), yet would almost certainly have been prevented had the AWS been working. A combination of TPWS and AWS is least effective in accidents like the one at Purley, where a driver repeatedly cancelled the AWS warning without applying the brakes, passing the danger signal at high speed. In this particular case though, the lower speed of the train and the very effective brakes of the EMU would have meant TPWS would likely have been effective anyway. Supporters of TPWS claim that even where it could not prevent accidents due to SPADs, it would likely reduce the impact, and reduce or eliminate fatalities, by at least slowing the train down.
Eventually, three prisoners escaped from the wagon; a fourth was shot. Three young students and members of the Belgian resistance including a Jewish doctor, Youra Livchitz (fr) and his two non-Jewish friends Robert Maistriau (fr)Robert Maistriau – his activity to save Jews' lives during the Holocaust, at Yad Vashem website and Jean Franklemon (fr), armed with one pistol, a lantern and red paper to create a makeshift red lantern (to use as a danger signal), were able to stop the train on the track Mechelen-Leuven, between the municipalities of Boortmeerbeek and Haacht. The twentieth convoy was guarded by one officer and fifteen men from the Sicherheitspolizei (SiPo-SD), who came from Germany. Despite these security measures, Maistriau was able to open one wagon and liberate 17 people.
The George Prince proceeded across the river, never changing course nor acknowledging radio traffic. According to the survivors, some of the passengers were aware of the Frosta as it traveled upriver, and there was a growing anxiety over what appeared to be a collision course, although this anxiety was somewhat tempered by their belief that the ferry would maneuver to avoid the ship, especially since there was no indication of danger from the George Prince. When the Frosta sounded the danger signal, there was an immediate panic from those who could see the ship, and their flight from danger alerted others. It can never be known whether the passengers on the side opposite the oncoming ship were aware of the danger, as all the survivors were on the side of the impact.
From the Coast Guard investigation report: # The captain of the Frosta, Kjell Sletten, was supervising his vessel's journey upriver via periodic visits to the pilothouse, observations he made by looking out his cabin window, and by the presence of his Mate, Peder Gasvaer, who was on the bridge. The mate was responsible to call the captain to the bridge in a situation that required his presence, although such situations were not defined. The mate did not notify Sletten until the sounding of the danger signal and the order for "full astern", seconds before the collision. The panel concluded that, although the bridge watch was not deficient, had the mate called for the captain earlier, that the captain may have had a lower threshold for the ferry's actions and might have acted sooner.
On the evening of 4 December 1957 there was heavy fog in the London area and trains were running late. The 5:18 pm Charing Cross to Hayes, comprising electric multiple units totalling 10 carriages and carrying nearly 1,500 passengers, stopped at a danger signal at Parks Bridge Junction on the South Eastern main line, under a bridge carrying rail tracks over the line. Trains were running out of order because of the fog and the Parks Bridge Junction signalman wished to speak to the driver by the telephone at the signal to confirm the train's identity and destination. At approximately 6:20 pm it was struck from behind by a train from Cannon Street to Ramsgate via Folkestone, consisting of Battle of Britain Class 4-6-2 no.
From the Coast Guard investigation report: # Circumstances of the collision prevent the usual application of the "Western Rivers Rules of the Road", which state that a vessel to the starboard has right-of-way (which is why all powered vessels have a red light facing to port, and a green light facing to starboard). George Prince was expected to do one of three things: head down river to pass behind the Frosta, slow and/or stop midstream and wait for the Frosta to pass, or proceed directly across to the West Bank. Only two minutes elapsed between the departure of the ferry and the collision. Since there was doubt as to the intention of the George Prince, and there was no response to attempts to determine the ferry's intentions, the duty of the pilot of the Frosta was to immediately reverse engine and sound the danger signal.
After many months of investigation and litigation, United States District Court, the Western District of Wisconsin Judge C. Z. Luce ruled that both masters were guilty of failing to follow the “Rules of the Road” regulations that if there is doubt about the course or intention of the other, the pilot is required give the danger signal and slow to a speed barely sufficient for passageway and/or stop and reverse course. After more haggling by underwriters and proctors, the Superior City was valued at $300,000 and her tonnage was valued at $42,922.95. The King's damage was $42,520. The loss-of-life claims were not paid until late in 1923. The lawyers of victim’s estates had little muscle against the legal maneuverings of the admiralty proctors and they settled for $5000 to the families of deckhands and porters, $3,700 for the wife of the second engineer, $11,205 for the second engineer, and $25,000 for the chief engineer.
Bacterial species that lack the non-mevalonate pathway and synthesize IPP via the classical mevalonate pathway instead, such as Streptococcus, Staphylococcus, and Borrelia, are unable to produce HMB-PP and do not specifically activate Vγ9/Vδ2 T cells. IPP itself is structurally closely related to HMB-PP and ubiquitously present in all living cells (including human cells), yet its potency in vitro is reduced 10,000-fold; whether IPP represents a physiological 'danger' signal of stressed or transformed cells is still unclear. Of pharmacological interest and with bioactivities comparable to that of IPP are synthetic aminobisphosphonates such as zoledronate (Zometa) or pamidronate (Aredia), that are widely used to treat osteoporosis and bone metastases, and incidentally act as Vγ9/Vδ2 T cell receptor agonists. However, increasing evidence suggests that these aminobisphosphonate 'antigens' are not recognised directly by Vγ9/Vδ2 T cells and in fact act indirectly, via their effects on the mevalonate biosynthetic pathway, leading to an accumulation of IPP.
The Board of Trade enquiry, subsequent to the inquest, concluded that Hutchings had not, in fact, given the "Train Entering Section" signal for the coal train after Quick had accepted it, and Quick had subsequently accepted the passenger train, having forgotten that he had accepted the coal train earlier. Hutchings was also criticised for not replacing his signals to "Danger" as soon as he was aware of the conflict – if he had done so, the driver of the passenger train would have had about 30 seconds to observe the danger signal, and, even if he had been unable to stop the train, its speed would have been greatly reduced and the collision much less severe. A contributory factor was the use of two-position block instruments, which did not have distinct "Line Blocked" and "Line Clear" indications. If a three-position instrument had been used, Hutchings would not have offered the passenger train forward (and Quick would not have accepted it) while the instrument was still showing "Line Clear" for the coal train.
The crash arose as three trains neared the junction at much the same time — a common enough occurrence. From the direction of Bradford, a Bradford-Harrogate train was following a route taking it in the direction of Guiseley; from the Leeds branch, a Leeds-Ilkley train was also heading towards Guiseley; whilst in the other direction an Ilkley-Bradford train approached the junction from Guiseley. Signalman Harry I'Anson, in the Esholt signal box, gave the Bradford-Harrogate train permission to pass the junction; meanwhile in the Apperley signal box, signalman Thomas Aubrey, knowing the Ilkley-Bradford train was approaching, gave the Leeds-Ilkley train permission to proceed towards the junction under a procedure called clause 16, which allowed trains to near the junction under the proviso that they were likely to encounter a danger signal before the junction proper. At the junction, the Leeds-Ilkley driver, Archibald McLay, despite acknowledging that he had been given a clause 16 permission, and in spite of his four and a half year's service on the line, mistook the proceed signal given to the Bradford-Harrogate train as relating to his line.

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