131 Sentences With "avidity" | Random Sentence Generator

Her avidity for experiencing all aspects of life was more important.

Not that cactuses are immune to the effects of human avidity.

But her intellectual avidity came coupled with mischief, worldliness and generosity.

Democratic voters are still working through their candidate lists with the avidity of a

We live in a world, I realize, that rates and ranks sexual gratification with Yelp-like avidity.

I ripped through the book with the avidity of Margaret attacking her morning vodka and orange juice.

But instead of vindicating Mr. Rockefeller's avidity for banking abroad, those figures underlined Chase's lagging performance at home.

The avidity with which their debuts will be watched suggests one conclusion: The era of the brand caretaker is over.

According to associates, Trump still has his old number that he used to work with the avidity of a telemarketer.

I looked into her eyes, straining to see some spark of avidity, of transgression, and got back a heavy stare.

Yet Mr. Hnath approaches what might seem like a hubristic project with the humility and avidity of an engaged Everyreader.

Catching the excitement of the impending visit, I began to read him with an avidity that has continued into the present.

Roc's avidity to take on odd jobs to keep his family afloat sometimes put him into abusive or morally compromising situations.

The avidity with which consumers snatched up even poor-quality CD reissues was a revelation: proof that catalogs could be cash cows.

He got on not so much by his wits as by his charm, and with youthful avidity he took in everything he saw and heard.

The journalistic avidity that fills this novel with captivating stories and tellingly observed details can also become an invented slickness that might be called novelism.

This was at his new Washington hotel, which he has been promoting with an avidity he has never devoted to, say, getting his immigration policy straight.

Or his clumsy avidity as he climbs into his mum's lap, like an overgrown mastiff that thinks it's still a puppy, or his defiant cuddling-up to the contact-averse Hench.

As readers, we may never achieve what he once described as Susan Sontag's "insatiable avidity," but a good critic should lure us on, so that our pursuit of their knowledge is irresistible.

Cable news networks offered saturation coverage, treating the arrival of Mr. Trump's jet into the Des Moines airport with an avidity reserved for heads of state, an irresistible image opposite an empty debate stage.

Eventually, they found that when a very fat person diets down to a normal weight, he or she physiologically comes to resemble a starving person, craving food with an avidity that is hard to imagine.

The reassuring part is that, if anything, he monitors Lucy's activities more avidly than Kirsten does—surely his avidity has egged on her own—and Lucy represents ninety per cent of all discussions between them.

"Sweetbitter" will be consumed with special avidity by young food people — sommeliers, cheesemakers, sous chefs, managers, pastry wizards — who dream of making it in the big city, or at least of making it by big-city standards.

"I was really surprised by the avidity of his interest," said Dr. Harold Varmus, who was a chairman of the board in its early days and was the director of the National Institutes of Health during the Clinton administration.

PETER J. KADZIK Assistant Attorney General for Legislative Affairs Washington To the Editor: The revelation that inspectors general have been stymied in doing their jobs comes, unfortunately, as no surprise, given this administration's avidity in pursuing the persecution and prosecution of whistle-blowers.

And I think about a virus that is more contagious than the seasonal flu, a virus with such a remarkable avidity for lung tissue that a significant number of patients — likely someone we know — can progress from cough to respiratory failure in a matter of days.

When this play was first seen on Broadway in 1987, in a Royal Shakespeare Company production staged by Howard Davies (a director of novelistic finesse who died last week), Lindsay Duncan and Alan Rickman slithered into its leading roles with the avidity of sleek, sexy foxes in a henhouse.

First staged in London, where it won the Olivier Award for best new play, the script merges the self-consciousness and avidity of its creator, Lopez, with that of its dramatis personae, who are in effect making up the work in which they appear as they go along.

The secret ingredient of the show is the when-in-Rome avidity with which Bourdain partakes of indigenous custom and cuisine, whether he is pounding vodka before plunging into a frozen river outside St. Petersburg or spearing a fatted swine as the guest of honor at a jungle longhouse in Borneo.

Avidity tests for rubella virus, Toxoplasma gondii, cytomegalovirus (CMV), varicella-zoster virus, human immunodeficiency virus (HIV), hepatitis viruses, Epstein-Barr virus, and others were developed a few years ago. These tests help to distinguish acute, recurrent or past infection by avidity of marker-specific IgG. Currently there are two avidity assays in use. These are the well known chaotropic (conventional) assay and the recently developed AVIcomp (avidity competition) assay.

The polyethylene glycol (PEG) assay precipitates DNA- antibody complexes, similar to the Farr Assay. However, unlike the Farr Assay it does not dissociate the low avidity antibody complexes, allowing for the detection of both high and low avidity anti-dsDNA antibodies.

Four years later, he was awarded the doctorate for his thesis, A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures.

In biochemistry, avidity refers to the accumulated strength of multiple affinities of individual non-covalent binding interactions, such as between a protein receptor and its ligand, and is commonly referred to as functional affinity. As such, avidity is distinct from affinity, which describes the strength of a single interaction. However, because individual binding events increase the likelihood of other interactions to occur (i.e. increase the local concentration of each binding partner in proximity to the binding site), avidity should not be thought of as the mere sum of its constituent affinities but as the combined effect of all affinities participating in the biomolecular interaction.

And all this to feed the avidity of a few millionary merchants and to keep up one thousand ships of war for the protection of their commercial speculations.

Brahmo missionaries, headed by Sen himself took to these occupations with workman-like avidity. The present Working Men’s Institution may well be regarded as the descendant of this Institution.

The Farr assay is one of the only tests available that detects high avidity antibodies (along with Crithidia luciliae) and also has the ability to detect antibodies of any isotype.

This test can produce false positives due to contamination of ssDNA from denatured dsDNA. EIA detects low and high avidity anti-dsDNA antibodies, increasing its sensitivity and reducing its specificity.

Each man grabbed his share with avidity, and there and then devoured it with such gulosity that, in less than half an hour after its death, only the hoofs remained.

Anti-dsDNA antibodies are highly associated with glomerulonephritis in SLE, although some patients with high titers of anti- dsDNA antibodies do not develop renal disease. This is most likely due to the fact that anti-dsDNA are a heterogeneous population, some of which have been found not to be pathogenic. Anti-dsDNA antibodies can be present in normal individuals, however these antibodies are usually low avidity IgM isotype. In contrast, pathogenic anti-dsDNA antibodies found in SLE are usually of IgG isotype and show high avidity for dsDNA.

Antigenic drift is this continuous process of genetic and antigenic change among flu strains. In human populations, immune (vaccinated) individuals exert selective pressure for single point mutations in the hemagglutinin gene that increase receptor binding avidity, while naive individuals exert selective pressure for single point mutations that decrease receptor binding avidity. These dynamic selection pressures facilitate the observed rapid evolution in the hemagglutinin gene. Specifically, 18 specific codons in the HA1 domain of the hemagglutinin gene have been identified as undergoing positive selection to change their encoded amino acid.

Avidity is commonly applied to antibody interactions in which multiple antigen-binding sites simultaneously interact with the target antigenic epitopes, often in multimerized structures. Individually, each binding interaction may be readily broken; however, when many binding interactions are present at the same time, transient unbinding of a single site does not allow the molecule to diffuse away, and binding of that weak interaction is likely to be restored. Each antibody has at least two antigen-binding sites, therefore antibodies are bivalent to multivalent. Avidity (functional affinity) is the accumulated strength of multiple affinities.

For example, IgM is said to have low affinity but high avidity because it has 10 weak binding sites for antigen as opposed to the 2 stronger binding sites of IgG, IgE and IgD with higher single binding affinities.

Similar to antibody, aptamers TBA and HD22 show avidity effect against thrombin after dimerization. When TBA and HD22 are conjugated with an optimal linkerHasegawa, H. et al., Improvement of Aptamer Affinity by Dimerization. Sensors 8, 1090-1098 doi:10.3390/s8021090(2008).

A particular important aspect relates to the phenomenon of 'avidity entropy'. Biomolecules often form heterogenous complexes or homogeneous oligomers and multimers or polymers. If clustered proteins form an organized matrix, such as the clathrin-coat, the interaction is described as a matricity.

Cartoon depiction of common oligomeric structures of lectins Many glycan binding proteins (GBPs) are oligomeric and typically contain multiple sites for glycan binding (also called carbohydrate-recognition domains). The ability to form multivalent protein-ligand interactions significantly enhances the strength of binding: while K_D values for individual CRD-glycan interactions may be in the mM range, the overall affinity of GBP towards glycans may reach nanomolar or even picomolar ranges. The overall strength of interactions is described as avidity K_D (in contrast with an affinity K_D which describes single equilibrium). Sometimes the avidity is also called an apparent K_D to emphasize the non-equilibrium nature of the interaction.

Also J. R. R. Tolkien said he read the book "with avidity", and praised it as a work of philosophy, religion, and morality. It was made widely available in paperback form when published as one of the precursor volumes to the Ballantine Adult Fantasy series in 1968.

The major advantage of the Immunobody® technology is that the Fc component of the engineered antibody will be recognised by the high affinity CD64 receptor present on dendritic cells, leading to a significant enhancement of both the frequency and avidity of the T cell immune response. The induction of high avidity T cells against TRP-2 and gp100 destroys both primary and metastatic tumours, leading to longer progression free survival. Phase I/II clinical trial of SCIB1 Scancell is conducting a Phase I/II clinical trial of SCIB1, its DNA ImmunoBody® vaccine being developed for the treatment of melanoma. The trial is being carried out at clinical sites in Nottingham, Manchester, Guildford, Leeds and Southampton. .

C5a plays a key role in increasing migration and adherence of neutrophils and monocytes to vessel walls. White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the autoimmune response.

Raw eggs should be avoided in those with biotin deficiency, because egg whites contain high levels of the anti- nutrient avidin. The name avidin literally means that this protein has an "avidity" (Latin: "to eagerly long for") for biotin. Avidin binds irreversibly to biotin and this compound is then excreted in the urine.

By this time Elizabeth had made good progress in music. For three years from the spring of 1786 she was under a governess, who taught her French and a little Italian. All her other linguistic attainments were of her own acquiring. The family had a good library, and she read with avidity, especially the poets.

Electron microscopy can identify secretory granules. There is usually minimal pleomorphism but less commonly there can be anaplasia, mitotic activity, and necrosis. Some neuroendocrine tumor cells possess especially strong hormone receptors, such as somatostatin receptors and uptake hormones strongly. This avidity can assist in diagnosis and may make some tumors vulnerable to hormone targeted therapies.

Since physical exercise induces temporary spikes of ROS, this may explain why physical exercise is beneficial for cancer patient prognosis. Moreover, high inducers of ROS such as 2-deoxy- D-glucose and carbohydrate-based inducers of cellular stress induce cancer cell death more potently because they exploit the cancer cell's high avidity for sugars.

Subsequent dimerisation or multimerisation can increase plasma half-life and, due to avidity, affinity to the target protein. Alternatively, multispecific Affilin molecules can be generated, binding different targets simultaneously. Radionuclides or cytotoxins can be conjugated to Affilin proteins, making them potential tumour therapeutics and diagnostics. Conjugation of cytokines has also been tested in vitro.

Avimers (short for avidity multimers) are artificial proteins that are able to specifically bind to certain antigens via multiple binding sites. Since they are not structurally related to antibodies, they are classified as a type of antibody mimetic. Avimers have been developed by the biotechnology company Avidia, now part of Amgen, as potential new pharmaceutical drugs.

When 11 years of age, she was received into the Presbyterian Church, and retained that connection. A year previously, her mother had removed to Pennsylvania and again married. In the stepfather's house, she often met itinerant lecturers upon temperance and anti-slavery, and she read with avidity the publications upon those subjects, and Sunday school and other religious books.

Under their creative influence he wrote his first lyrical poems. In his early satirical poems he criticized social deficiencies in the society, superstition and narrow-mindedness, tyranny and unfairness. These poems would enter his first collection of poems titled The Result of Avidity. Later, under the influence of Fuzûlî’s and Seyid Azim’s works, he began to write ghazels.

They get hold of Kannan and his friends. Revathy and Kannan are separated. After two years, Kannan returns from Oman after having worked as a site engineer there, to meet his love. He meets her with avidity and they talk for a while when she asks him to leave immediately, for fear that her father would harm him.

Patients with rheumatoid arthritis can develop anti-dsDNA antibodies, however they are usually treatment related. Anti-TNFα biological therapies, such as adalimumab, infliximab and etanercept, can often induce the production of anti-dsDNA antibodies. They are usually low avidity and are only detectable transiently after treatment. The presence of these antibodies can induce a lupus-like syndrome in some cases.

Crithidia luciliae is a haemoflagellate protist with an organelle known as the kinetoplast. This organelle contains a high concentration of circular DNA with no recognisable nuclear antigens, allowing for the reliable detection of anti-dsDNA antibodies. The kinetoplast fluoresces if serum contains high avidity anti- dsDNA antibodies. This test has a higher specificity than EIA because it uses unprocessed DNA.

The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. Surprisingly there was no changes in activity of Cish's purported target, STAT5. Thus Cish represents a new class of T-cell intrinsic immunologic checkpoints with the potential to radically enhance adoptive immunotherapies for cancer.

Amongst those are the mouse anti rat-TfR antibody OX26 and the rat anti mouse-TfR antibody 8D3. The affinity of the antibody-TfR interaction seems to be important determining the success of transcytotic transport over endothelial cells of the BBB. Monovalent TfR interaction favors BBB transport due to altered intracellular sorting pathways. Avidity effects of bivalent interactions redirecting transport to the lysosome .

Von Bülow entered the Prussian army in 1773. Routine work proved distasteful to him, and he read with avidity the works of Jean Charles, Chevalier Folard and other theoretical writers on war, and of Rousseau. After sixteen years service he left Prussia, and endeavoured without success to obtain a commission in the Austrian army. He then returned to Prussia, and for some time managed a theatrical company.

Furthermore, the dimerization improves the anticoagulant activity as well. The TBA-HD22 construct (linked with 16-mer polyA) shows significant improvement both in the assay of activated partial thromboplastin time, clotting time and thrombin-induced platelet-aggregation. TBA-HD22 construct shows comparable efficacy compared with bivalirudin, but much more potent than argatroban. In addition, the TBA-HD22 avidity can be examined by ecarin clotting time.

Activation of RANK by RANKL promotes the maturation of pre- osteoclasts into osteoclasts. Denosumab inhibits this maturation of osteoclasts by binding to and inhibiting RANKL. This mimics the natural action of osteoprotegerin, an endogenous RANKL inhibitor, that presents with decreasing concentrations (and perhaps decreased avidity) in patients who are suffering from osteoporosis. This protects bone from degradation, and helps to counter the progression of the disease.

When this happens, the new variant of the virus preferentially reactivates memory B cells and stimulates the production of appropriate antibodies. However, the antibodies produced by these B cells tend to bind inefficiently to the altered antigens. They often experience loss of affinity and avidity. In addition, these antibodies inhibit the activation of naive B cells, which could produce more effective neutralizing antibodies to the second variant of the virus.

It was observed that IFN-τ decreased intracellular HIV RNA in human macrophages and inhibited reverse transcription of viral RNA into proviral DNA. Because of difference in both selectivity of individual N-termini towards receptors and different degree of receptor avidity, IFN-τ displays much less cytotoxicity than IFNT-α. This can be useful in treatment of viral diseases. IFN-τ has also demonstrated biological effects against influenza virus.

Matricity is the interaction of a matrix with its environment. This word is used particularly of protein interactions, where a polymerised protein (a matrix) interacts with a membrane or another polymer. Protein interactions can normally be described by their affinities for each other. The interactions of clustered proteins for multivalent ligands are described by avidities (avidity), while matricity describes a semisolid state interaction of a matrix with its environment.

Like most siderophores, pyoverdine is synthesized and secreted into the environment when the microorganism that produces it detects that intracellular iron concentrations have fallen below a preset threshold. Although iron is the fourth-most abundant element in the Earth's crust, solubility of biologically relevant iron compounds is exceedingly low, and is generally insufficient for the needs of most (but not all) microorganisms. Siderophores, which are typically quite soluble and have exceptionally high avidity for iron (III) (the avidity of some siderophores for iron exceeds 10 M and many of the strongest avidities ever observed in nature are exhibited by siderophores for iron), help increase bioavailability of iron by pulling it into aqueous solution. In addition to this role, pyoverdine has a number of other functions, including regulating virulence, limiting the growth of other bacterial species (and serving as a sort of antimicrobial) by limiting iron availability, and sequestering other metals and preventing their toxicity.

There are many commercially available immunologic adjuvants. Selection of specific adjuvants or types varies depending upon whether they are to be used for research and antibody production or in vaccine development. Adjuvants for vaccine use only need to produce protective antibodies and good systemic memory while those for antiserum production need to rapidly induce high titer, high avidity antibodies. No single adjuvant is ideal for all purposes and all have advantages and disadvantages.

Philosophy itself is with him classification and consideration of ideas. Logic he regarded as a practical art, and his Esercizio logico has the further title, Art of deriving benefit from ill-constructed books. In ethics Gioja follows Bentham generally, and his large treatise Del merito e delle recompense (1818) is a clear and systematic view of social ethics from the utilitarian principle. In political economy this avidity for facts produced better fruits.

At present, the family consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, expression levels, catalytic regulation, cellular localization, membrane binding avidity and tissue distribution. All are capable of catalyzing the hydrolysis of PIP2 into two important second messenger molecules, which go on to alter cell responses such as proliferation, differentiation, apoptosis, cytoskeleton remodeling, vesicular trafficking, ion channel conductance, endocrine function and neurotransmission.

She was a pioneer in showing conclusively that thymocyte selection is based on an affinity/avidity model. She was also the first to demonstrate that self-reactive peripheral T cells can remain in a naïve state in the T cell repertoire; a concept that has become widely known as T cell “ignorance”. This has led to Ohashi’s current approach in understanding how to manipulate and improve cytotoxic T cells to enhance the immune response against cancer.

In principle, MHC procedures are using the T cell receptor (TCR) ligand, which is the MHC-peptide complex, as a staining probe. The MHC interacts with the TCR, which in turn is expressed on the T cells. Because TCR-MHC interactions have only a very weak affinity towards each other, monomeric MHC-epitope complexes cannot provide stable binding. This problem can be solved by using multimerized MHC-epitopes, which increases the binding avidity and therefore allows stable binding.

Additionally, the grouping and binding together of multiple immune complexes allows for an increase in the avidity, or strength of binding, of the FcRs. This allows innate immune cells to get multiple inputs at once and prevents them from being activated early. Immune complexes may themselves cause illness when they are deposited in organs, for example, in certain forms of vasculitis. This is the third form of hypersensitivity in the Gell-Coombs classification, called type III hypersensitivity.

Avimers consist of two or more peptide sequences of 30 to 35 amino acids each, connected by linker peptides. The individual sequences are derived from A domains of various membrane receptors and have a rigid structure, stabilised by disulfide bonds and calcium. Each A domain can bind to a certain epitope of the target protein. The combination of domains binding to different epitopes of the same protein increases affinity to this protein, an effect known as avidity (hence the name).

Within the thymus, pre-T cells undergo a selection process where they must be positively selected and should avoid negative selection. B cells that bind with low avidity to self- MHC receptors are positively selected for maturation, those that do not die by apoptosis. Cells that survive positive selection, but bind strongly to self- antigens are negatively selected also by active induction of apoptosis. This negative selection is known as clonal deletion, one of the mechanisms for B cell tolerance.

From the 1500s, the people of Barlovento, plantation owners and their African slaves, developed an avidity for the feast of San Juan. Celebrations with music and dancing were made. Despite the objections of Bishop Mariano Marti to these "ridiculous and earthly diversions" when he visited the region in 1784, the festival continued to gain in popularity. The date of the feast, June 25, aligned with the harvesting of the cocoa bean crop, the onset of the wet season and the summer solstice.

Based on the IgG avidity test, if the IgG in the infected individual has a high affinity, it means that the infection began three to five months before testing. This is particularly useful in congenital infection, where pregnancy status and gestational age at time of infection determines treatment. In contrast to IgG, IgM antibodies can be used to detect acute infection but generally not chronic infection. The IgM antibodies appear sooner after infection than the IgG antibodies and disappear faster than IgG antibodies after recovery.

Mendelssohn was not thought of highly, Mozart and Haydn "were considered out of date and naïve", and J.S. Bach merely mathematical and unfeeling. Berlioz "was highly esteemed", Liszt "crippled and perverted from a musical point of view ... even a caricature", and Wagner discussed little. Rimsky-Korsakov "listened to these opinions with avidity and absorbed the tastes of Balakirev, Cui and Mussorgsky without reasoning or examination". Often, the musical works in question "were played before me only in fragments, and I had no idea of the whole work".

It is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. The sites are on the CH2 domain of IgG and, it is thought, on the CH4 domain of IgM. IgG4 cannot bind C1q, but the other three IgG types can. The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.

Pentamers consist of five MHC-peptide headgroups, arranged in a planar configuration so that, unlike MHC tetramers, all of the headgroups can contact the CD8+ T cell. The headgroups are connected via flexible linkers to a coiled-coil multimerization domain, which in turn is connected to five fluorescent or biotin tags. Pentamers are available with APC, R-PE, or biotin labelling, and also unlabelled with separate tags for long-term storage. Pentamers offer enhanced brightness and avidity of staining compared with other multimer reagents.

DNA-primed immune responses can be boosted by the administration of recombinant protein or recombinant poxviruses. "Prime-boost" strategies with recombinant protein have successfully increased both neutralising antibody titre, and antibody avidity and persistence, for weak immunogens, such as HIV-1 envelope protein. Recombinant virus boosts have been shown to be very efficient at boosting DNA- primed CTL responses. Priming with DNA focuses the immune response on the required immunogen, while boosting with the recombinant virus provides a larger amount of expressed antigen, leading to a large increase in specific CTL responses.

The court cupboards, with their solid or open under parts and upper cornice supported by turned balusters of extravagant thickness, are to be seen wherever one goes. And chairs, real as well as spurious, with solid backs carved in the usual flat relief, are bought up with an avidity inseparable from fashion. Four-post bedsteads are harder to come by. The back is usually broken up into small panels and carved, the best effect being seen in those examples where the paneling or the framework only is decorated.

As of 2017, SAMs for most Siglecs have been reported, except for Siglec -6, -8, -11, -14, -15 and -16. Clustering of receptors and high-avidity binding, collectively known as multivalent binding, can enhance the effectiveness of SAMs in human body. Currently, advancements in glycoengineering have made use of SAM-decorated nanoparticles, SAM-decorated polymers and on-cell synthesis of SAMs to present SAMs to Siglecs. Liposomes crosslinked with SAMs also have been shown to aid in presenting antigens to antigen-presenting cells via the Siglec-1 or -7 pathways.

Has been shown to interact with CISH which negatively regulates it by targeting it for degradation. The deletion of Cish in effector T cells has been shown to augment TCR signaling and subsequent effector cytokine release, proliferation and survival. The adoptive transfer of tumor- specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. There are no changes in activity or phosphorylation of Cish's purported target, STAT5 in either the presence or absence of Cish.

He never really talked; at most he would sometimes mutter words such as tobacco, bread or wine, but without any link to the desire of smoking, eating or drinking. When he ate, he did it with avidity, but then he was able not to eat for a week at a time. He was easygoing and even obliging, and whichever simple task he was asked to do, he would do it promptly but without enthusiasm. After nine years living in such a fashion, he went to the sea to swim and was never seen again.

How although we preferred the Works of the Ancients we have not condemned the Studies of the Moderns Antiquorum tamen examinatos labors securiori aviditate cupivimus perscrutari. In chapter 9, we see in de Bury the general trend of the Catholic Church during this time to recognize the wisdom of the Greek classical writers such as Plato, Ovid, Euclid and others. For de Bury and others like him, "we have always desired with more undoubting avidity to investigate the well-tested labours of the ancients".de Bury, p. 99 10\.

We see frequently the vices and follies of the powerful much less despised than the poverty and weakness of the innocent. To deserve, to acquire, and to enjoy the respect and admiration of mankind, are the great objects of ambition and emulation. Two different roads are presented to us, equally leading to the attainment of this so much desired object; the one, by the study of wisdom and the practice of virtue; the other, by the acquisition of wealth and greatness. Two different characters are presented to our emulation; the one, of proud ambition and ostentatious avidity.

Recent research has led to the discovery that unstable hinged monospecific antibodies may engage in a process leading to a decrease in their apparent avidity/affinity. This process, termed Fab arm exchange, has led to theories about the dissemination of viral infections in patients given monospecific IgG4 therapeutic antibodies. Evidence is suggestive that this process is linked to the dissemination of PML in patients given Tysabri for MS. Following dosing unpredictability still reigns and mutations in the hinge of the antibody which may prevent Fab-arm exchange in-vivo should be considered when designing therapeutic antibodies.

He became a full-time writer there. His novel A Voyage to Arcturus was published in 1920, but it was not a success, selling fewer than six hundred copies. The work shows links with Scottish fantasists such as George MacDonald, whose work Lindsay was familiar with, and it had a central influence on C. S. Lewis's Out of the Silent Planet.Kathryn Lindskoog – A Voyage to Arcturus, C. S. Lewis, and The Dark Tower J. R. R. Tolkien said that he had read the book "with avidity", and characterised it as a work of philosophy, religion and morality.

Ribi adjuvants are oil-in-water emulsions where antigens are mixed with small volumes of a metabolizable oil (squalene) which are then emulsified with saline containing the surfactant Polysorbate 80. This system also contains refined mycobacterial products (cord factor, cell wall skeleton) as immunostimulants and bacterial monophosphoryl lipid A. Three different species oriented formulations of the adjuvant system are available. These adjuvants interact with membranes of immune cells resulting in cytokine induction, which enhances antigen uptake, processing and presentation. This adjuvant system is much less toxic and less potent than FCA but generally induces satisfactory amounts of high avidity antibodies against protein antigens.

At the same time, the G-protein subunit Gα directly activates an enzyme called protein tyrosine kinase (PTK), which phosphorylates serine and threonine residues in the tail of the chemokine receptor, causing its desensitisation or inactivation. The initiated MAP kinase pathway activates specific cellular mechanisms involved in chemotaxis, degranulation, release of superoxide anions, and changes in the avidity of cell adhesion molecules called integrins. Chemokines and their receptors play a crucial role in cancer metastasis as they are involved in extravasation, migration, micrometastasis, and angiogenesis. This role of chemokine is strikingly similar to their normal function of localizing leukocytes to an inflammatory site.

IgG antibodies usually appear within a week or two of infection, peak within one to two months, then decline at various rates. Toxoplasma IgG antibodies generally persist for life, and therefore may be present in the bloodstream as a result of either current or previous infection. To some extent, acute toxoplasmosis infections can be differentiated from chronic infections using an IgG avidity test, which is a variation on the ELISA. In the first response to infection, toxoplasma- specific IgG has a low affinity for the toxoplasma antigen; in the following weeks and month, IgG affinity for the antigen increases.

After a time the daughter was sent to such a school as, in those early days, was to be found; and there the avidity with which she applied her mind to study injured her health. She persevered, however, until she had acquired all that her teachers could communicate, and had herself mastered the usual qualifications of a teacher. Of these, as her father's flock was poor and his means limited, she subsequently availed herself, keeping school at Rising Sun, in order to aid her parents and to procure, for herself, the means of purchasing the books she craved.

Affibody molecules are based on a three-helix bundle domain, which can be expressed in soluble and proteolytically stable forms in various host cells on its own or via fusion with other protein partners. They tolerate modification and are independently folding when incorporated into fusion proteins. Head-to-tail fusions of Affibody molecules of the same specificity have proven to give avidity effects in target binding, and head-to-tail fusion of Affibody molecules of different specificities makes it possible to get bi- or multi-specific affinity proteins. Fusions with other proteins can also be created genetically or by spontaneous isopeptide bond formation.

Second, SLiMs have relatively low affinity for their interaction partners (generally between 1 and 150 μM), which makes these interactions transient and reversible, and thus ideal to mediate dynamic processes such as cell signaling. In addition, this means that these interactions can be easily modulated by post-translational modifications that change the structural and physicochemical properties of the motif. Also, regions of high functional density can mediate molecular switching by means of overlapping motifs (e.g. the C-terminal tails of integrin beta subunits), or they can allow high avidity interactions by multiple low affinity motifs (e.g.

In the Foreword to Davies' biography of Phillpotts, Prof. Norman Sykes summarises the character of the Bishop: > Henry of Exeter, like Job’s war-horse, snuffed the battle from afar; and > scented, moreover, a remarkable number and variety of contests in which to > engage, without exhausting his capacity for polemic. Like William Warburton > of an earlier age (though perhaps he would not have relished the comparison) > he was a born fighter. It was his fortune furthermore to live in an age when > occasions of dispute were legion; and he threw himself with avidity into > their several aspects.

Dextramer technology is currently used in academic and clinical research due to their increased specificity and binding affinity, which allows for increased avidity for specific T-cells and enhances staining intensity. This advantage is a result of the increased ability of Dextramers to bind multiple times to a single T-cell, improving the stability of this interaction as compared with other multimer technologies such as pentamers and tetramers. Further applications include the ability to isolate antigen specific T-cell populations as well as in situ detection using immunohistochemistry (IHC) for various disease states (e.g. solid tumors).

RGDs) eventually kill the cancer cell if the nuclide decays in the vicinity of the cell. Especially oligo- or multimers of these binding motifs are of great interest, since this can lead to enhanced tumor specificity and avidity. Photodynamic therapy (PDT) is a ternary treatment for cancer involving a photosensitizer, tissue oxygen, and light (often using lasersDuarte, F J (Ed.), Tunable Laser Applications (CRC, New York, 2009) Chapters 5, 7, 8.). PDT can be used as treatment for basal cell carcinoma (BCC) or lung cancer; PDT can also be useful in removing traces of malignant tissue after surgical removal of large tumors.

Protein kinase C, phosphoinositide 3-kinase, and phospholipase C (PLC) are all needed for signalling and controlling particle internalisation. More cell surface receptors can bind to the particle in a zipper-like mechanism as the pathogen is surrounded, increasing the binding avidity. Fc receptor (FcR), complement receptors (CR), mannose receptor and Dectin-1 are phagocytic receptors, which means that they can induce phagocytosis if they are expressed in non-phagocytic cells such as fibroblasts. Other proteins such as Toll-like receptors are involved in pathogen pattern recognition and are often recruited to phagosomes but do not specifically trigger phagocytosis in non-phagocytic cells, so they are not considered phagocytic receptors.

At the same time, in patients who subsequently recovered, the antibody titer increased more slowly, but rose to a higher level and stayed at this level longer. This dynamics of changes in antibody titers was characteristic of both IgM and IgG antibodies. It can be assumed that patients who subsequently died developed an antibody-dependent increase in viral infection in severe form and the rapid production of antibodies to the S-protein, which could not neutralize the virus, contributed to this. It is possible that the slower titer rise contributed to the production of antibodies with a higher binding constant corresponding to stronger antigen-antibody complexes, with higher affinity and avidity.

Chromatofocusing is a protein-separation technique that allows resolution of single proteins and other ampholytes from a complex mixture according to differences in their isoelectric point. Chromatofocusing utilizes ion exchange resins and is typically performed on fast protein liquid chromatography (FPLC) or similar equipment capable of producing continuous buffer gradients though this is not a requirement. In contrast to typical ion exchange chromatography, where bound molecules are eluted from the resin by increasing the ionic strength of the buffer environment, chromatofocusing elutes bound species by altering the pH of the buffer. This changes the net surface charge of bound molecules, altering their avidity for the resin.

The campaign of 1761 was almost as abortive as the campaign of 1760. Frederick acted on the defensive with consummate skill, and the capture of the Prussian fortress of Kolberg on Christmas Day 1761, by Rumyantsev, was the sole Russian success. Frederick, however, was now at the last gasp. On 6 January 1762, he wrote to Count Karl-Wilhelm Finck von Finckenstein, "We ought now to think of preserving for my nephew, by way of negotiation, whatever fragments of my territory we can save from the avidity of my enemies", which meant, if words mean anything, that he was resolved to seek a soldier's death on the first opportunity.

Advantages of yeast display over other in vitro evolution methods include eukaryotic expression and processing, quality control mechanisms of the eukaryotic secretory pathway, minimal avidity effects, and quantitative library screening through fluorescent-activated cell sorting (FACS). Yeast are eukaryotic organisms that allow for complex post- translational modifications to proteins that no other display libraries are able to provide. Disadvantages include smaller mutant library sizes compared to alternative methods and differential glycosylation in yeast compared to mammalian cells. These disadvantages have not limited the success of yeast display for a number of applications, including engineering the highest monovalent ligand-binding affinity reported to date for an engineered protein (Boder, E.T. 2000).

One of the earliest preparations is that of Walker and Johnston, who made it by the salt metathesis reaction of tetramethylammonium chloride and potassium hydroxide in dry methanol, in which TMAH is soluble, but potassium chloride is not: :NMe4+Cl− \+ KOH → NMe4+ \+ KCl Where Me stands for the methyl group, CH3-. This report also provides details for isolation of TMAH as its pentahydrate, noting the existence of a trihydrate, and emphasizes the avidity which even the former exhibits for atmospheric moisture and carbon dioxide. These authors reported a m.p. of 62–63 °C for the pentahydrate, and a solubility in water of 220 g/100 mL at 15 °C.

The four years after his release from the Tower were mainly passed in retirement, but on the accession of Queen Anne, he plunged into political life again with avidity. His first act was to draw down on himself in February 1702 the censure of the House of Commons for the part which he took in the attempt to secure the return of his nominee for the borough of Malmesbury. Through the fear of the ministry that his restless spirit would drive him into opposition to its measures if he stayed at home, he was appointed early in 1705 to command an expedition to Spain, during the War of the Spanish Succession.

In the former book – read with avidity throughout Germany.Robertson, James Burton (1839). "The Life and Writings of Görres," The Dublin Review 6, p. 37. – Görres describes the moral, intellectual and political corruption of France in the course of the eighteenth century as the major cause which led to the revolution: Joseph Görres in 1838, drawing by F. Diez In his pamphlet Die heilige Allianz und die Völker auf dem Congresse von Verona ("The Holy Alliance and the peoples represented at the congress of Verona", 1822) Görres asserted that the princes had met together to crush the liberties of the people, and that the people must look elsewhere for help.

Lactobacillus rhamnosus GG (ATCC 53103) is a strain of L. rhamnosus that was isolated in 1983 from the intestinal tract of a healthy human being; filed for a patent on 17 April 1985, by Sherwood Gorbach and Barry Goldin, the 'GG' derives from the first letters of their surnames. The patent refers to a strain of "L. acidophilus GG" with American Type Culture Collection (ATCC) accession number 53103; later reclassified as a strain of L. rhamnosus. The patent claims the L. rhamnosus GG (ATCC 53103) strain is acid- and bile-stable, has a great avidity for human intestinal mucosal cells, and produces lactic acid.

For this reason IgM has sometimes been called a "natural antibody". This phenomenon is probably due to the high avidity of IgM that allow it to bind detectably even to weakly cross- reacting antigens that are naturally occurring. For example, the IgM antibodies that bind to the red blood cell A and B antigens might be formed in early life as a result of exposure to A- and B-like substances that are present on bacteria or perhaps also on plant materials. IgM antibodies are mainly responsible for the clumping (agglutination) of red blood cells if the recipient of a blood transfusion receives blood that is not compatible with their blood type.

Her Moral Inheritance, was founded upon "Soul Heredity" and entered into rather novel fields in the realms of fiction. In her Life of La Fayette she had access to original files of newspapers, unique copies of works now out of print, and the private papers of the La Fayette family, and thus was able to incorporate in the book much that had been inaccessible to previous biographers. She completed a historical novel, The Doom of the Holy City: Christ and Casar, founded on the destruction of Jerusalem, and the scenes were laid in that city and in Rome as they appeared in the first century. She was an indefatigable student, pursuing metaphysical and philosophical research with intense avidity.

Chemokine receptors associate with G-proteins to transmit cell signals following ligand binding. Activation of G proteins, by chemokine receptors, causes the subsequent activation of an enzyme known as phospholipase C (PLC). PLC cleaves a molecule called phosphatidylinositol (4,5)-bisphosphate (PIP2) into two second messenger molecules known as Inositol triphosphate (IP3) and diacylglycerol (DAG) that trigger intracellular signaling events; DAG activates another enzyme called protein kinase C (PKC), and IP3 triggers the release of calcium from intracellular stores. These events promote many signaling cascades (such as the MAP kinase pathway) that generate responses like chemotaxis, degranulation, release of superoxide anions and changes in the avidity of cell adhesion molecules called integrins within the cell harbouring the chemokine receptor.

55 are described in Pali sources as leading Greek ("Yona", i.e., Ionian) Buddhist monks, active in Buddhist proselytism (the Mahavamsa, XII).Full text of the Mahavamsa Click chapter XII It is also thought that Greeks contributed to the sculptural work of the Pillars of Ashoka,"The finest of the pillars were executed by Greek or Perso-Greek sculptors; others by local craftsmen, with or without foreign supervision" Marshall, "The Buddhist art of Gandhara", p4 and more generally to the blossoming of Mauryan art."A number of foreign artisans, such as the Persians or even the Greeks, worked alongside the local craftsmen, and some of their skills were copied with avidity" Burjor Avari, "India, The ancient past", p.

Depending on the tissue type and the method of antigen detection, endogenous biotin or enzymes may need to be blocked or quenched, respectively, prior to antibody staining. Although antibodies show preferential avidity for specific epitopes, they may partially or weakly bind to sites on nonspecific proteins (also called reactive sites) that are similar to the cognate binding sites on the target antigen. A great amount of non-specific binding causes high background staining which will mask the detection of the target antigen. To reduce background staining in IHC, ICC and other immunostaining methods, samples are incubated with a buffer that blocks the reactive sites to which the primary or secondary antibodies may otherwise bind.

The novel was a central influence on C. S. Lewis's 1938–1945 Space Trilogy. Lewis also mentioned the "sorbing" (aggressive absorption of another's personality into one's own, fatal to the other person) as an influence on his 1942 book The Screwtape Letters. Lewis in turn recommended the book to J. R. R. Tolkien, who said he read it "with avidity", finding it more powerful, more mythical but less of a story than Lewis's Out of the Silent Planet; he commented that "no one could read it merely as a thriller and without interest in philosophy[,] religion[,] and morals". In 1984, the composer John Ogdon wrote an oratorio for soprano, mezzosoprano, tenor, and baritone accompanied by choir and piano entitled, A Voyage to Arcturus.

CTLA4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. CTLA4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4.

Catharine, the youngest, was early remarkable for her sagacious intellect, for her facility in acquiring knowledge, her cleverness in teaching herself the art of penmanship, and her delight in making extemporary verse. Nothing is recorded of her education, but from her own allusion to it in her "Poem on the Busts", it may be inferred to have been slight and ordinary. Nothing, however, could repress her eager desire for information; and obstacles, as usual, proved incentives to effort. She read with avidity, and wrote with emulative zeal; works of imagination occupying, as in such cases they are wont, her childish attention; and these, as her reasoning powers matured, and her judgment became formed, giving place to tractates and treatises on moral philosophy and religion.

They often try to avoid employing full-time employees (FTEs) in favor of part-time employees (PTEs) or contingent workers (for example, temporary workers, freelancers, cottage workers, contractors (who may have subcontractors), or day labourers), all of which usually entail less obligation for employee benefits (compensation beyond the wages themselves). Agencies tasked with enforcing labour law are supposed to be perennially on guard against the avidity with which employers find clever ways to make people function like FTEs but carry nominal labels as contractors, freelancers, or PTEs (e.g., dishonest worker classification, unpaid overtime). Other avenues of discount labour are the institutions of apprenticeship and cooperative education (including work-study programs), and (relatedly) the informal tradition of the "broke college student who works for peanuts".

The heroine was decidedly more naughty than mid- Victorian heroines were wont to be, and the book had deservedly a great vogue, firmly establishing the author's position. Macquoid also made her mark as the writer of travel books, such as Through Normandy, Through Brittany, In the Ardennes, Pictures in Umbria, and In the Volcanic Eifel, which were illustrated by her husband. Macquoid had her early struggles for recognition, but she was encouraged at different times by George Lillie Craik, George Grove, G. H. Lewes, and Sir Frederic Leighton. Her work was appreciated by parents as her stories were not only interesting, but could be read with avidity by young girls for they were not "silly" or of the "milk-and-water" variety.

Multimeric forms of Affimer proteins have been generated and shown to yield titrimetric volumes in the range of 200–400 mg/L under small scale culture using bacterial host systems. Multimeric forms of Affimer proteins with the same target specificity provided avidity effects in target binding, while fusion of different Affimer proteins with different target specificities would enable multi-specific affinity proteins. Many different tags and fusion proteins, such as fluorophores, single-stranded DNA, His, and c-Myc tags can be easily conjugated to Affimer proteins. Specific cysteine residues can be introduced to the protein to allow thiol chemistry to uniformly orient Affimer proteins on a solid support for the purposes of increasing target capture in ligand binding assays and biosensors.

" Sokolsky's 14-year-long stint in China enabled him to hold himself out as an expert on Asian matters upon his repatriation to the U.S. His experience of Chinese culture was tinged with ambivalence: "Perhaps in no other city does so much human energy go into the search for amusement as among the foreign population of Shanghai. Ladies go to their amusements with even greater avidity. Work at home can always be done by boys and amahs and club life becomes the center of one's aims and ambitions. Dinner parties at clubs and hotels, night after night of dancing and jazz, turn the sweet girl who comes here to marry a man out East into a tired matron while still in her thirties: blasé, wearied and uninterested in life.

The Orphan of the Rhine was a gothic novel by Eleanor Sleath, listed as one of the seven "horrid novels" by Jane Austen in her novel Northanger Abbey. Subtitled "A Romance" it was published in four volumes the sensationalist Minerva Press in 1798. It was part of a brief but popular vogue of German tales, a fashion criticized in the Critical Review of June 1807 "So great is the rage for German tales, and German novels, that a cargo is no sooner imported than the booksellers' shops are filled with a multitude of translators, who seize with avidity and without discrimination, whatever they can lay their hands upon...[these novels are] trash...[and] worthless objects." Although most gothic novels took a resolutely anti-Roman Catholic stance, the author of this novel was herself a Catholic.

" Mary McNamara, of the Los Angeles Times dubbed it "a perfect finish to an astonishingly ambitious show that often careened through genre, narrative structure and believability like they were false walls on a stage". In her rumination on the finale, Ginia Bellafante of The New York Times noted that "[Big Love] was always at its most compelling as an indictment of the mindless spiritual avidity and the bizarre displays of self-exoneration that can go on in the name of faith," and celebrated the finale for committing to that theme. She also wrote that the series had "achieved the resonance of [HBO's] other heralded series." Writing for TV Squad, Dr. Ryan Vaughn was less enthusiastic about the finale but said, "I'm not going to let a great series be sullied with a mediocre finale.

Many vasoactive chemicals have been hypothesized as being involved in mediating the systemic hemodynamic changes, including atrial natriuretic factor, prostacyclin, thromboxane A2, and endotoxin. In addition to this, it has been observed that the administration of medications to counteract splanchnic vasodilation (such as ornipressin, terlipressin, and octreotide) leads to improvement in glomerular filtration rate (which is a quantitative measure of kidney function) in patients with hepatorenal syndrome, providing further evidence that splanchnic vasodilation is a key feature of its pathogenesis. The underfill theory involves activation of the renin–angiotensin–aldosterone system, which leads to an increase in absorption of sodium from the kidney tubule (termed renal sodium avidity) mediated by aldosterone, which acts on mineralocorticoid receptors in the distal convoluted tubule. This is believed to be a key step in the pathogenesis of ascites in cirrhotics as well.

As a response to criticism by Dr Ferdinando Moroni, Dr Ghirotti from Padua vehemently defended Frari’s work in "Giornale veneto di science mediche" in 1868. Ghirotti accused Moroni of ignorance and avidity (as “being the aspirant on the position at the Cathedra in Padua”). Ghirotti discussed the obstetrical issues which were mentioned in the Frari’s textbook, such as symphisiotomy, pelvic/fetal head diameters, fetal/maternal auscultation, geminal and extra-uterine pregnancy, mola, menstrual cycles, anatomical variations of the uterus, maternal alimentation, infertility, and death in utero. He concluded that Professor Michele Carlo Frari was a highly qualified obstetrician and skilled surgeon, reliable and extremely appreciated for his work, and that his textbook was “written according to true principals of the art, with the right criteria and argumentation, based on proper experience and on opinions of celebrated obstetricians of various nations” (20).

It was claimed to be effective in curing many diseases and in increasing vitality, but was also said to have several side effects." Needham and Lu (1974:288) refer to Sun's prescriptions for wushisan and hanshisan ("powder of the five minerals" and "swallowed-cold powder"), as well as wushi gengsheng san ( "five minerals resurrection powder"), and wushi huming san ( " five minerals life-preserving powder"), "all to be used in cases of sexual debility". Sun Simiao attributed one formula, the cishi hanshisan ( "purple mineral cold powder") to the Han Dynasty doctor Zhang Zhongjing, and remarked, "There have also been those who have acquired an addiction to the Five-Mineral preparations on account of their avidity for the pleasures of the bedchamber", namely Daoist sexual practices. They conclude, "China was certainly not the only civilisation to believe that arsenic had aphrodisiac properties; such a view long prevailed in the West.

MET signaling complex MET activation by its ligand HGF induces MET kinase catalytic activity, which triggers transphosphorylation of the tyrosines Tyr 1234 and Tyr 1235. These two tyrosines engage various signal transducers, thus initiating a whole spectrum of biological activities driven by MET, collectively known as the invasive growth program. The transducers interact with the intracellular multisubstrate docking site of MET either directly, such as GRB2, SHC, SRC, and the p85 regulatory subunit of phosphatidylinositol-3 kinase (PI3K), or indirectly through the scaffolding protein Gab1 Tyr 1349 and Tyr 1356 of the multisubstrate docking site are both involved in the interaction with GAB1, SRC, and SHC, while only Tyr 1356 is involved in the recruitment of GRB2, phospholipase C γ (PLC-γ), p85, and SHP2. GAB1 is a key coordinator of the cellular responses to MET and binds the MET intracellular region with high avidity, but low affinity.

Arundell was born at Launceston, Cornwall, in July 1780, being the only son of Thomas Jago, a solicitor in that town, who had married Catherine, a daughter of Mr. Bolt, a surgeon at Launceston. Francis was educated at Liskeard Grammar School and at Exeter College, Oxford, where he took the degree of M.A. in 1809, and after having been ordained in the Church of England he took a curacy at Antony in his native county. From youth to old age Arundell was imbued with a love of antiquarian study, and after his institution in 1805 to the rectory of Landulph on the banks of the Tamar, he threw himself with avidity into the history of Cornwall. When Nicholas Condy, an artist at Plymouth, published a series of views of Cotehele, the ancient seat of Lord Mount Edgcumbe, Arundell supplied the description of the house which accompanied them.

In about 1767, Bishop William Warburton asked Ruffhead to undertake the task of digesting into a volume his materials for a critical biography of Alexander Pope. Warburton reserved to himself the reading of the proof-sheets and the supervision of the plan. Ruffhead set to work with the methodical industry that was habitual to him, and the result appeared in 1769 (preface dated Middle Temple, 2 January) as The Life of Alexander Pope, from Original Manuscripts, with a Critical Essay on his Writings and Genius in an appendix were printed letters from Pope to Aaron Hill. Though tame and lifeless, the book was read with avidity as affording for the first time a quantity of authentic information about the best-known name of a literary epoch; four editions appeared within the year (one at Dublin), and the work was translated into French (it was also prefixed to Pope's Works, Paris, 1799).

Landulph Church Francis Vyvyan Jago was born at Launceston, in July 1780, being the only son of Thomas Jago. (He afterwards adopted the additional surname of "Arundell".) From youth to old age Jago was imbued with a love of antiquarian study, and after his institution in 1805 to the rectory of Landulph he threw himself with avidity into the history of Cornwall. In the church of Landulph is a brass to the memory of Theodore Paleologus, descended from the last of the Christian emperors of Greece, who died on 21 January 1637, and an account of this inscription, and of the person whom it commemorated, was printed by Jago in the volume of the Archæologia for 1817, and reprinted in Davies Gilbert's Cornwall (iii, 365). This paper was afterwards amplified into Some Notice of the Church of Landulph, which was published in 1840, and a reprint of which, with additions by Joseph Polsue of Bodmin, was announced some years ago (i.e.

He took up the post in February 1883. He and Heath (who had been appointed to counterbalance Cooke's suspected political loyalties) worked harmoniously and efficiently, but when Heath retired (or was relieved of his position), Cooke continued in the role alone with no obvious reduction in the Office's effectiveness. He :"possessed uncommon gifts as a mathematician, a vein of dry humour, he was well informed on all current topics, with a particularly good knowledge of the political history of the State and of Australia centrally and, tbough he at one time took a prominent part in public affairs, and discussed with avidity questioned before Parliament, after his induction to the control of the Audit Office he 'knew no politics'" Under his leadership, the Audit Office evolved from an investigative body to a powerful arm of Government, giving advice, and to some extent control, outside its original remit. He supported the formation of the Public Service Association in 1884, and was its first president.

He was in such demand that Davison, in an 1860 biographic sketch, noted that "he became one of the most fashionable professors of the day, and his lessons were both sought with avidity and remunerated at a rate of payment which knew no precedent except in the instance of John Cramer."Davison, quoted in Craw, p. 51 He had also established a relationship with pianomaker John Broadwood, taking delivery of one of the first 5½ octave pianos (FF-c4): Broadwood noted in his business journal for 13 November 1793: "We have made some 5 ½ octave grands these three years past, the first to please Dussek, which being liked, Cramer junior had one".Craw, p. 53 His collaboration with Broadwood would continue to bear fruit when, in 1794, he also received the first 6-octave (CC-c4) pianoCraw, p. 75 In the spring of 1791, Dussek appeared in a series of concerts, a number of which featured Sophia, the young daughter of music publisher Domenico Corri. In a concert on 15 June that year, the pair played a piano duet together; they were married in September 1792.Craw, pp. 58–60 Sophia Corri was a singer, pianist, and harpist who became known in her own right.